8-Hydroxyquinoline_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 8-Hydroxyquinoline perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the 8-Hydroxyquinoline_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DST dystonin 0.0620481
PSD3 pleckstrin and Sec7 domain containing 3 0.0512633
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0494677
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0492765
CADM2 cell adhesion molecule 2 0.0385105
MACF1 microtubule-actin crosslinking factor 1 0.0317286
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0283962
NPAS2 neuronal PAS domain protein 2 0.02737
CSMD3 CUB and Sushi multiple domains 3 0.0267013
ERRFI1 ERBB receptor feedback inhibitor 1 0.0265633
ENO1 enolase 1, (alpha) 0.0260617
RPS12 ribosomal protein S12 0.0252279
LDHA lactate dehydrogenase A 0.0248918
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0240986
ZDHHC14 zinc finger, DHHC-type containing 14 0.0226994
EFNA5 ephrin-A5 0.0223879
TNS3 tensin 3 0.0221405
CANX calnexin 0.0221212
TTC3 tetratricopeptide repeat domain 3 0.021914
PRELID2 PRELI domain containing 2 0.0216264
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0215131
RPS18 ribosomal protein S18 0.0206073
RPL37A ribosomal protein L37a 0.0186379
CAPRIN2 caprin family member 2 0.0184446
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0184444
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0181963
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0181711
ZSWIM6 zinc finger, SWIM-type containing 6 0.01798
SDK1 sidekick cell adhesion molecule 1 0.0177137
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0175916
TSC22D1 TSC22 domain family, member 1 0.0175382
SQSTM1 sequestosome 1 0.0173606
CALR calreticulin 0.0171355
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0162218
LOXL2 lysyl oxidase-like 2 0.0162028
RPL31 ribosomal protein L31 0.0156506
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0155861
EGFR epidermal growth factor receptor 0.0155011
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0151873
EPHA4 EPH receptor A4 0.0148313
ANGPTL4 angiopoietin-like 4 0.014773
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0147252
HOMER1 homer scaffolding protein 1 0.0144632
RPL37 ribosomal protein L37 0.0143919
INTS6 integrator complex subunit 6 0.0141041
CXCL8 chemokine (C-X-C motif) ligand 8 0.0137908
DPYD dihydropyrimidine dehydrogenase 0.0137002
SOD2 superoxide dismutase 2, mitochondrial 0.0136411
KDM4C lysine (K)-specific demethylase 4C 0.0134945
TP63 tumor protein p63 0.0131035
BIRC3 baculoviral IAP repeat containing 3 0.0129942
PDE10A phosphodiesterase 10A 0.0128941
HDLBP high density lipoprotein binding protein 0.0128642
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0128074
PYGL phosphorylase, glycogen, liver 0.012621
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0123378
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0121944
EXOC4 exocyst complex component 4 0.0119406
RPS27 ribosomal protein S27 0.0118357
DENND1A DENN/MADD domain containing 1A 0.0118085
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0114966
LYST lysosomal trafficking regulator 0.0114097
RACK1 receptor for activated C kinase 1 0.0113178
ADARB1 adenosine deaminase, RNA-specific, B1 0.0112499
GOLGB1 golgin B1 0.0112071
DNER delta/notch-like EGF repeat containing 0.0112013
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0111876
CFLAR CASP8 and FADD-like apoptosis regulator 0.0110747
LPP LIM domain containing preferred translocation partner in lipoma 0.0109973
MYOF myoferlin 0.010991
NEK10 NIMA-related kinase 10 0.0109799
RPS8 ribosomal protein S8 0.0107863
ARHGAP5 Rho GTPase activating protein 5 0.0106543
PGM3 phosphoglucomutase 3 0.010526
APLP2 amyloid beta (A4) precursor-like protein 2 0.0101939
IFI6 interferon, alpha-inducible protein 6 0.0101442
PKM pyruvate kinase, muscle 0.00993352
GOLGA3 golgin A3 0.00981538
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.00974784
HDAC9 histone deacetylase 9 0.00963537
EEF1G eukaryotic translation elongation factor 1 gamma 0.00951721
PGK1 phosphoglycerate kinase 1 0.00942892
PLIN2 perilipin 2 0.00936285
RUNX1 runt-related transcription factor 1 0.00934086
PLK2 polo-like kinase 2 0.00919322
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.00905552
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.00901843
JUN jun proto-oncogene 0.00900658
MCL1 myeloid cell leukemia 1 0.00899202
HSPH1 heat shock 105kDa/110kDa protein 1 0.00897239
MBNL2 muscleblind-like splicing regulator 2 0.00896729
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.00890288
CAPN2 calpain 2, (m/II) large subunit 0.00888284
HM13 histocompatibility (minor) 13 0.00882715
DOCK1 dedicator of cytokinesis 1 0.00881656
SRSF9 serine/arginine-rich splicing factor 9 0.00871395
UBAP2 ubiquitin associated protein 2 0.00860826
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.00857862
ARFGEF3 ARFGEF family member 3 0.00852811
PDIA4 protein disulfide isomerase family A, member 4 0.00849108

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.102189
PTMA prothymosin, alpha -0.0608885
POTEF POTE ankyrin domain family, member F -0.0531398
TMSB10 thymosin beta 10 -0.0416175
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0374567
TMSB4X thymosin beta 4, X-linked -0.0353909
CENPF centromere protein F, 350/400kDa -0.0336936
DLG1 discs, large homolog 1 (Drosophila) -0.0314208
ACTG1 actin gamma 1 -0.0308529
VIM vimentin -0.030838
PRRC2C proline-rich coiled-coil 2C -0.0302688
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0271458
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0250653
MT1X metallothionein 1X -0.0244809
RTN4 reticulon 4 -0.0243463
RBM25 RNA binding motif protein 25 -0.0242906
MKI67 marker of proliferation Ki-67 -0.0242294
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0239555
SMC4 structural maintenance of chromosomes 4 -0.0224636
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.022424
SRPK2 SRSF protein kinase 2 -0.0221942
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0218944
TOP1 topoisomerase (DNA) I -0.0218414
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0203892
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0201198
PTK2 protein tyrosine kinase 2 -0.0196921
DIAPH3 diaphanous-related formin 3 -0.0192056
WARS1 tryptophanyl-tRNA synthetase 1 -0.0190531
THOC2 THO complex 2 -0.0184422
STRN3 striatin, calmodulin binding protein 3 -0.018285
MATR3 matrin 3 -0.0180882
RPL35A ribosomal protein L35a -0.0174076
GARS1 glycyl-tRNA synthetase 1 -0.0170908
ZMYND8 zinc finger, MYND-type containing 8 -0.0170666
KMT2C lysine (K)-specific methyltransferase 2C -0.0168357
ECT2 epithelial cell transforming 2 -0.016753
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0166852
PNISR PNN-interacting serine/arginine-rich protein -0.01652
CD44 CD44 molecule (Indian blood group) -0.0164642
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0160337
NOP58 NOP58 ribonucleoprotein -0.0158497
BRWD1 bromodomain and WD repeat domain containing 1 -0.01569
NCOR1 nuclear receptor corepressor 1 -0.0154868
ZNF292 zinc finger protein 292 -0.0154344
DEK DEK proto-oncogene -0.0153647
MARCHF6 membrane associated ring-CH-type finger 6 -0.0153429
SETD5 SET domain containing 5 -0.015288
CHD1 chromodomain helicase DNA binding protein 1 -0.0152841
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0151928
ZFR zinc finger RNA binding protein -0.0151889
PUM2 pumilio RNA-binding family member 2 -0.0150994
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0148693
ADGRG6 adhesion G protein-coupled receptor G6 -0.0148275
QKI QKI, KH domain containing, RNA binding -0.0147228
RBM39 RNA binding motif protein 39 -0.0146964
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0143272
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0142201
MTF2 metal response element binding transcription factor 2 -0.0142053
MIS18BP1 MIS18 binding protein 1 -0.0141829
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0141606
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -0.01382
OLA1 Obg-like ATPase 1 -0.0137895
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0137163
KMT2E lysine (K)-specific methyltransferase 2E -0.0136941
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0135934
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0135274
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.01352
RPS21 ribosomal protein S21 -0.0134659
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0133129
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0132625
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0132402
ANKRD28 ankyrin repeat domain 28 -0.0132063
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0132005
RPS24 ribosomal protein S24 -0.0131817
TRA2A transformer 2 alpha homolog (Drosophila) -0.0131555
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0130972
PHIP pleckstrin homology domain interacting protein -0.013029
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0129779
TCERG1 transcription elongation regulator 1 -0.0129758
IFIH1 interferon induced with helicase C domain 1 -0.01293
SEPTIN7 septin 7 -0.0128196
PFN1 profilin 1 -0.0128065
CELF1 CUGBP, Elav-like family member 1 -0.0128057
KDM3A lysine (K)-specific demethylase 3A -0.012801
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0127763
RSRC2 arginine/serine-rich coiled-coil 2 -0.0126595
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -0.0126109
PTBP2 polypyrimidine tract binding protein 2 -0.0126062
FLNB filamin B, beta -0.0125956
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0125561
RIGI RNA sensor RIG-I -0.0125184
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0125103
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0124198
WASF2 WAS protein family, member 2 -0.0124091
FOXJ3 forkhead box J3 -0.0123186
BRD4 bromodomain containing 4 -0.0122412
RSRC1 arginine/serine-rich coiled-coil 1 -0.0122208
SLC38A2 solute carrier family 38, member 2 -0.0122184
TPX2 TPX2, microtubule-associated -0.0121256
KLF6 Kruppel-like factor 6 -0.0121196