8-Hydroxyquinoline_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 8-Hydroxyquinoline perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 8-Hydroxyquinoline_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MCL1 myeloid cell leukemia 1 0.0547736
AKAP12 A kinase (PRKA) anchor protein 12 0.0525861
ERRFI1 ERBB receptor feedback inhibitor 1 0.0497271
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0450868
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.040917
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0340643
PDE4D phosphodiesterase 4D, cAMP-specific 0.0312589
ZCCHC7 zinc finger, CCHC domain containing 7 0.0300215
RAD51B RAD51 paralog B 0.0299488
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0298667
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0269261
THSD4 thrombospondin, type I, domain containing 4 0.0258535
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0251664
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.023743
AEBP2 AE binding protein 2 0.0230108
CANX calnexin 0.0229474
ZSWIM6 zinc finger, SWIM-type containing 6 0.0216984
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0215269
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0212223
SYNE2 spectrin repeat containing, nuclear envelope 2 0.020899
EXOC4 exocyst complex component 4 0.0203391
KTN1 kinectin 1 (kinesin receptor) 0.0202468
GRAMD1B GRAM domain containing 1B 0.0201382
TPM3 tropomyosin 3 0.0192882
ATXN1 ataxin 1 0.0192863
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0192738
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0192393
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.019165
DST dystonin 0.0191626
INTS6 integrator complex subunit 6 0.0190421
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0189322
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0189036
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0182513
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0181329
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0180523
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.017945
MACF1 microtubule-actin crosslinking factor 1 0.0176971
AFF3 AF4/FMR2 family, member 3 0.0175927
USP34 ubiquitin specific peptidase 34 0.0175305
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0173584
AHNAK AHNAK nucleoprotein 0.0169721
RIMS2 regulating synaptic membrane exocytosis 2 0.0167052
FNDC3B fibronectin type III domain containing 3B 0.0165997
PDLIM5 PDZ and LIM domain 5 0.0165429
TAS2R14 taste receptor, type 2, member 14 0.0163166
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0161293
GOLGB1 golgin B1 0.0161223
WWOX WW domain containing oxidoreductase 0.0160348
PRELID2 PRELI domain containing 2 0.0159853
PRKCE protein kinase C, epsilon 0.0159767
TRIP12 thyroid hormone receptor interactor 12 0.0158832
ELL2 elongation factor, RNA polymerase II, 2 0.0158682
PHF3 PHD finger protein 3 0.0155921
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0154377
ZFAND3 zinc finger, AN1-type domain 3 0.0152602
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0152089
MYH9 myosin, heavy chain 9, non-muscle 0.0149002
EEF2 eukaryotic translation elongation factor 2 0.0148147
VMP1 vacuole membrane protein 1 0.014759
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0146161
WNK1 WNK lysine deficient protein kinase 1 0.0145603
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0143336
DOCK5 dedicator of cytokinesis 5 0.0143232
IGF1R insulin-like growth factor 1 receptor 0.0139772
SETX senataxin 0.0139619
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0139439
COPA coatomer protein complex, subunit alpha 0.0138587
MBD5 methyl-CpG binding domain protein 5 0.0138446
YAP1 Yes-associated protein 1 0.0136158
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0135977
ANO6 anoctamin 6 0.0133304
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.01322
VCL vinculin 0.0131127
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0130965
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0130295
PRH1 proline-rich protein HaeIII subfamily 1 0.0125747
JMJD1C jumonji domain containing 1C 0.0124763
HOMER1 homer scaffolding protein 1 0.012423
FBXO11 F-box protein 11 0.0124084
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0123833
PDIA6 protein disulfide isomerase family A, member 6 0.0122536
VCP valosin containing protein 0.0121777
LPP LIM domain containing preferred translocation partner in lipoma 0.0121332
DSPP dentin sialophosphoprotein 0.0120616
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0119906
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0119704
R3HDM2 R3H domain containing 2 0.0119158
BPTF bromodomain PHD finger transcription factor 0.011882
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0118788
EXT1 exostosin glycosyltransferase 1 0.0117854
ZNF638 zinc finger protein 638 0.01178
FMNL2 formin-like 2 0.011689
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.011604
ZBTB1 zinc finger and BTB domain containing 1 0.011539
SND1 staphylococcal nuclease and tudor domain containing 1 0.0115041
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0114956
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0114719
HMGA2 high mobility group AT-hook 2 0.0113992
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0113351
TLN1 talin 1 0.0112953

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.0514264
PTMA prothymosin, alpha -0.0265803
RPL35A ribosomal protein L35a -0.0222692
TPI1 triosephosphate isomerase 1 -0.0198407
TFPI2 tissue factor pathway inhibitor 2 -0.0197486
YBX3 Y box binding protein 3 -0.0185319
RPS21 ribosomal protein S21 -0.018484
MT2A metallothionein 2A -0.0182608
MYL12B myosin, light chain 12B, regulatory -0.0174364
RPS3 ribosomal protein S3 -0.0167307
PFN1 profilin 1 -0.0162451
TPT1 tumor protein, translationally-controlled 1 -0.0153447
RPL37 ribosomal protein L37 -0.0129301
HLA-B major histocompatibility complex, class I, B -0.0126447
KLF6 Kruppel-like factor 6 -0.0112917
RBM25 RNA binding motif protein 25 -0.0110886
RPS12 ribosomal protein S12 -0.0109666
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0109254
RPL11 ribosomal protein L11 -0.0105638
RPL26 ribosomal protein L26 -0.0105234
MT1X metallothionein 1X -0.0104787
FTL ferritin, light polypeptide -0.0104751
RPL12 ribosomal protein L12 -0.0102403
RPL36 ribosomal protein L36 -0.0100412
RPL9 ribosomal protein L9 -0.00992729
IGF2 insulin-like growth factor 2 -0.00953269
EGR1 early growth response 1 -0.00925472
RPLP0 ribosomal protein, large, P0 -0.0088149
EIF4A1 eukaryotic translation initiation factor 4A1 -0.00854832
RPS29 ribosomal protein S29 -0.00854729
RPLP1 ribosomal protein, large, P1 -0.00853884
HMGA1 high mobility group AT-hook 1 -0.00852641
VDAC1 voltage-dependent anion channel 1 -0.00824584
RPL19 ribosomal protein L19 -0.00823182
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.00820634
PABPN1 poly(A) binding protein, nuclear 1 -0.00785701
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0077569
GSTP1 glutathione S-transferase pi 1 -0.00774268
RPS24 ribosomal protein S24 -0.0077309
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.00769195
RPL36A ribosomal protein L36a -0.00768245
BASP1 brain abundant, membrane attached signal protein 1 -0.00758257
EIF5B eukaryotic translation initiation factor 5B -0.00757087
ZBTB7A zinc finger and BTB domain containing 7A -0.00746112
ATP5F1E ATP synthase F1 subunit epsilon -0.00744665
TM4SF1 transmembrane 4 L six family member 1 -0.0073083
RPLP2 ribosomal protein, large, P2 -0.00729531
RPL23 ribosomal protein L23 -0.0072533
KPNB1 karyopherin (importin) beta 1 -0.00719754
IFI6 interferon, alpha-inducible protein 6 -0.00701304
H3-3B H3.3 histone B -0.00700344
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.00699617
RPS15 ribosomal protein S15 -0.00691428
MIDN midnolin -0.00685806
RPL34 ribosomal protein L34 -0.00674244
RTN4 reticulon 4 -0.00671708
S100A6 S100 calcium binding protein A6 -0.00671506
UBTF upstream binding transcription factor, RNA polymerase I -0.00667688
SSB Sjogren syndrome antigen B (autoantigen La) -0.00663222
ATP5F1B ATP synthase F1 subunit beta -0.00662893
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.00658647
RPS19 ribosomal protein S19 -0.00658582
CBX3 chromobox homolog 3 -0.00652931
TMEM165 transmembrane protein 165 -0.006418
SERF2 small EDRK-rich factor 2 -0.00640625
S100A11 S100 calcium binding protein A11 -0.00636046
RACK1 receptor for activated C kinase 1 -0.00632985
ZCRB1 zinc finger CCHC-type and RNA binding motif 1 -0.00631424
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.00607265
LOC102724023 ES1 protein homolog, mitochondrial -0.00600049
NOP58 NOP58 ribonucleoprotein -0.00598149
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.00592059
CAVIN1 caveolae associated protein 1 -0.00587149
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.00583447
RPL31 ribosomal protein L31 -0.00583144
BSG basigin (Ok blood group) -0.00582587
SINHCAF SIN3-HDAC complex associated factor -0.00575563
NEMF nuclear export mediator factor -0.00574694
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.00572287
UQCRB ubiquinol-cytochrome c reductase binding protein -0.00571735
RPS27 ribosomal protein S27 -0.00570574
ROMO1 reactive oxygen species modulator 1 -0.00563494
OSMR oncostatin M receptor -0.00563216
RPL8 ribosomal protein L8 -0.00556218
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0055471
TUBA1C tubulin, alpha 1c -0.00554494
RPS10 ribosomal protein S10 -0.00546744
ZFP36L1 ZFP36 ring finger protein-like 1 -0.00543772
RPL37A ribosomal protein L37a -0.00542865
RPS27A ribosomal protein S27a -0.00533684
SF3B6 splicing factor 3b, subunit 6, 14kDa -0.00518293
TUBA1B tubulin, alpha 1b -0.00515203
SEPTIN7 septin 7 -0.00515167
TUBB4B tubulin, beta 4B class IVb -0.00512323
S100A9 S100 calcium binding protein A9 -0.00508004
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.00506088
RPL7L1 ribosomal protein L7-like 1 -0.00497803
PTPRF protein tyrosine phosphatase, receptor type, F -0.0049062
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.00490142
PA2G4 proliferation-associated 2G4, 38kDa -0.00481397