8-Hydroxyquinoline_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 8-Hydroxyquinoline perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 8-Hydroxyquinoline_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.0936039
SOD2 superoxide dismutase 2, mitochondrial 0.0528647
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0514641
FN1 fibronectin 1 0.0491472
COL6A3 collagen, type VI, alpha 3 0.0467179
SMAD3 SMAD family member 3 0.0335918
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0291353
THBS1 thrombospondin 1 0.028514
BICC1 BicC family RNA binding protein 1 0.0283826
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0282176
AHNAK AHNAK nucleoprotein 0.0273767
FNDC3B fibronectin type III domain containing 3B 0.0261014
USP9X ubiquitin specific peptidase 9, X-linked 0.0242703
DST dystonin 0.0238661
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0228811
MSN moesin 0.0217361
EXT1 exostosin glycosyltransferase 1 0.0216005
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0196695
TNS3 tensin 3 0.0194599
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0193809
FAM20C family with sequence similarity 20, member C 0.0189843
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0180658
TNIP1 TNFAIP3 interacting protein 1 0.0172908
TXNRD1 thioredoxin reductase 1 0.0170896
MX1 MX dynamin-like GTPase 1 0.0159209
VCAN versican 0.0154309
ATXN1 ataxin 1 0.0153378
PCBP2 poly(rC) binding protein 2 0.0153349
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0148656
VMP1 vacuole membrane protein 1 0.0145295
RPS18 ribosomal protein S18 0.014481
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0144206
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.014279
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0139885
ANLN anillin, actin binding protein 0.0131363
NONO non-POU domain containing, octamer-binding 0.0130437
ARF4 ADP-ribosylation factor 4 0.0129739
PLEC plectin 0.0127688
MLPH melanophilin 0.0125868
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0124127
CEP250 centrosomal protein 250kDa 0.0122028
FRMD4A FERM domain containing 4A 0.0121249
APLP2 amyloid beta (A4) precursor-like protein 2 0.0118544
TSC22D2 TSC22 domain family, member 2 0.0117103
ZNF608 zinc finger protein 608 0.0116587
EIF4B eukaryotic translation initiation factor 4B 0.0112633
MKI67 marker of proliferation Ki-67 0.0112016
OGA O-GlcNAcase 0.0111726
AHR aryl hydrocarbon receptor 0.0110936
ANO6 anoctamin 6 0.0108406
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa 0.0107071
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0106661
TRIP12 thyroid hormone receptor interactor 12 0.0105301
UTRN utrophin 0.0104487
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0102978
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0102653
ZNF451 zinc finger protein 451 0.0101527
TGFB2 transforming growth factor, beta 2 0.0100537
STAT1 signal transducer and activator of transcription 1, 91kDa 0.00996613
UBA6 ubiquitin-like modifier activating enzyme 6 0.00986926
RUNX2 runt-related transcription factor 2 0.00974725
ARRDC3 arrestin domain containing 3 0.00953418
EZR ezrin 0.00947949
DLG1 discs, large homolog 1 (Drosophila) 0.00945746
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.00930491
KLF7 Kruppel-like factor 7 (ubiquitous) 0.00925652
SHB Src homology 2 domain containing adaptor protein B 0.00920097
CKAP5 cytoskeleton associated protein 5 0.00915447
LNPEP leucyl/cystinyl aminopeptidase 0.00913837
AFDN afadin, adherens junction formation factor 0.00913776
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.00909885
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.009057
HPS3 Hermansky-Pudlak syndrome 3 0.00904073
PHC3 polyhomeotic homolog 3 (Drosophila) 0.00902785
DCBLD1 discoidin, CUB and LCCL domain containing 1 0.00898702
RIGI RNA sensor RIG-I 0.00897196
FLNA filamin A, alpha 0.00896477
YEATS2 YEATS domain containing 2 0.00876531
KDM6A lysine (K)-specific demethylase 6A 0.00867454
CEP112 centrosomal protein 112kDa 0.0086701
NAV2 neuron navigator 2 0.00854338
GLS2 glutaminase 2 (liver, mitochondrial) 0.00853375
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.00852136
WDR27 WD repeat domain 27 0.00848525
VEGFA vascular endothelial growth factor A 0.00847622
PDGFC platelet derived growth factor C 0.00842824
LRRC7 leucine rich repeat containing 7 0.00840195
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.00838924
DIAPH3 diaphanous-related formin 3 0.00833476
ARHGAP29 Rho GTPase activating protein 29 0.00826775
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.00825546
YAP1 Yes-associated protein 1 0.00822287
PTPRK protein tyrosine phosphatase, receptor type, K 0.0082141
TOP2A topoisomerase (DNA) II alpha 170kDa 0.00821409
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.00821297
LCOR ligand dependent nuclear receptor corepressor 0.00816489
PRICKLE2 prickle homolog 2 (Drosophila) 0.00813562
RBM39 RNA binding motif protein 39 0.0080526
TPM3 tropomyosin 3 0.00804737
CENPF centromere protein F, 350/400kDa 0.00804614

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.348395
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.205502
TPT1 tumor protein, translationally-controlled 1 -0.140341
HLA-B major histocompatibility complex, class I, B -0.139997
FTL ferritin, light polypeptide -0.122976
IER3 immediate early response 3 -0.112492
TMSB10 thymosin beta 10 -0.104097
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0977043
AKAP12 A kinase (PRKA) anchor protein 12 -0.0893378
MT2A metallothionein 2A -0.0751068
ADM adrenomedullin -0.0686697
CD44 CD44 molecule (Indian blood group) -0.0674464
PTMA prothymosin, alpha -0.0592652
RPS24 ribosomal protein S24 -0.056824
RPL35A ribosomal protein L35a -0.0552835
RPS6 ribosomal protein S6 -0.0550952
STC1 stanniocalcin 1 -0.0547409
HLA-A major histocompatibility complex, class I, A -0.0539915
BASP1 brain abundant, membrane attached signal protein 1 -0.0532882
RPS8 ribosomal protein S8 -0.0525887
NDRG1 N-myc downstream regulated 1 -0.0494894
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0492517
CDH13 cadherin 13 -0.0477854
EIF1 eukaryotic translation initiation factor 1 -0.04748
B2M beta-2-microglobulin -0.0473615
RPL37A ribosomal protein L37a -0.0470444
ZMYND8 zinc finger, MYND-type containing 8 -0.0459009
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0450405
RPL23 ribosomal protein L23 -0.0450266
BTG1 B-cell translocation gene 1, anti-proliferative -0.0444146
PLIN2 perilipin 2 -0.0416021
CTSD cathepsin D -0.0413002
RPLP2 ribosomal protein, large, P2 -0.0410135
NAP1L1 nucleosome assembly protein 1-like 1 -0.0404021
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0399186
RPS21 ribosomal protein S21 -0.0397984
ACTG1 actin gamma 1 -0.0383377
RPS13 ribosomal protein S13 -0.0379763
SFRP1 secreted frizzled-related protein 1 -0.0374642
RPS3 ribosomal protein S3 -0.0370276
FTH1 ferritin, heavy polypeptide 1 -0.0364111
TMSB4X thymosin beta 4, X-linked -0.0358965
RPL9 ribosomal protein L9 -0.0358834
UBC ubiquitin C -0.0357268
IGFBP3 insulin-like growth factor binding protein 3 -0.0354863
RAB7A RAB7A, member RAS oncogene family -0.0354522
RPL36A ribosomal protein L36a -0.0353133
RPL11 ribosomal protein L11 -0.0350322
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0350118
RPL26 ribosomal protein L26 -0.0341721
GNAS GNAS complex locus -0.034125
EGR1 early growth response 1 -0.033858
RND3 Rho family GTPase 3 -0.0336816
RPS12 ribosomal protein S12 -0.0334303
RPL12 ribosomal protein L12 -0.0332521
ARL4C ADP-ribosylation factor-like 4C -0.0332186
RPLP1 ribosomal protein, large, P1 -0.032855
HLA-E major histocompatibility complex, class I, E -0.032847
RPS23 ribosomal protein S23 -0.0322682
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0318776
SLC38A1 solute carrier family 38, member 1 -0.0318571
HMGA2 high mobility group AT-hook 2 -0.0318268
ENO1 enolase 1, (alpha) -0.0315849
RPL19 ribosomal protein L19 -0.0310073
CTSB cathepsin B -0.0308521
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0305084
RPL7A ribosomal protein L7a -0.0303312
RPS27A ribosomal protein S27a -0.0298281
RPLP0 ribosomal protein, large, P0 -0.0298219
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0296685
S100A9 S100 calcium binding protein A9 -0.029484
RPS4X ribosomal protein S4, X-linked -0.0291316
PGK1 phosphoglycerate kinase 1 -0.0284856
COL1A1 collagen, type I, alpha 1 -0.0272408
UGCG UDP-glucose ceramide glucosyltransferase -0.0270694
RPL32 ribosomal protein L32 -0.0269808
RPL34 ribosomal protein L34 -0.0267436
RACK1 receptor for activated C kinase 1 -0.0267333
RPS25 ribosomal protein S25 -0.0264518
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0258288
HMGA1 high mobility group AT-hook 1 -0.0258086
INHBA inhibin, beta A -0.0256911
RPS19 ribosomal protein S19 -0.0255728
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0255414
IFITM3 interferon induced transmembrane protein 3 -0.025384
IFI16 interferon, gamma-inducible protein 16 -0.025156
NRN1 neuritin 1 -0.02466
RPS14 ribosomal protein S14 -0.0243414
VDAC1 voltage-dependent anion channel 1 -0.0236159
RPS10 ribosomal protein S10 -0.0234244
TMEM132D transmembrane protein 132D -0.023389
RPL38 ribosomal protein L38 -0.0231083
KPNB1 karyopherin (importin) beta 1 -0.0230049
RPL5 ribosomal protein L5 -0.0229445
RPL37 ribosomal protein L37 -0.0226892
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0224043
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0222939
MT1X metallothionein 1X -0.0221897
HILPDA hypoxia inducible lipid droplet-associated -0.0220761
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0211921