8-Hydroxyquinoline_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 8-Hydroxyquinoline perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 8-Hydroxyquinoline_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
INTS6 integrator complex subunit 6 0.0283788
NRG1 neuregulin 1 0.0256582
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0228388
ZSWIM6 zinc finger, SWIM-type containing 6 0.0216653
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0170443
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0139557
HMGA2 high mobility group AT-hook 2 0.0129282
AEBP2 AE binding protein 2 0.0126973
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0118346
ZCCHC7 zinc finger, CCHC domain containing 7 0.0102076
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.00995503
EFNA5 ephrin-A5 0.00980848
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.00910075
PALLD palladin, cytoskeletal associated protein 0.00867655
ZNF638 zinc finger protein 638 0.00862623
LIMCH1 LIM and calponin homology domains 1 0.00849589
SAMD4A sterile alpha motif domain containing 4A 0.00837446
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.00807569
MAML2 mastermind-like 2 (Drosophila) 0.00805079
ASCC3 activating signal cointegrator 1 complex subunit 3 0.00801787
GLIS3 GLIS family zinc finger 3 0.00801152
CCSER1 coiled-coil serine-rich protein 1 0.00759517
RUNX1 runt-related transcription factor 1 0.00754494
FNIP1 folliculin interacting protein 1 0.00742222
TRIO trio Rho guanine nucleotide exchange factor 0.00703898
LRRC23 leucine rich repeat containing 23 0.00692798
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.00680464
KDM4C lysine (K)-specific demethylase 4C 0.00680332
FRY furry homolog (Drosophila) 0.00669611
NABP1 nucleic acid binding protein 1 0.00647429
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.00631921
CEMIP2 cell migration inducing hyaluronidase 2 0.00629336
UBAP2 ubiquitin associated protein 2 0.00626068
CCDC138 coiled-coil domain containing 138 0.00625074
PDE7A phosphodiesterase 7A 0.00621136
GPR75-ASB3 GPR75-ASB3 readthrough 0.00594571
POU2F2 POU class 2 homeobox 2 0.00591559
TUFT1 tuftelin 1 0.00586022
TAS2R14 taste receptor, type 2, member 14 0.00578318
EXT1 exostosin glycosyltransferase 1 0.00574178
RASAL2 RAS protein activator like 2 0.00566772
CEMIP cell migration inducing protein, hyaluronan binding 0.00564096
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.00555029
GPATCH2 G patch domain containing 2 0.00535523
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.00534494
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.00528015
DOCK5 dedicator of cytokinesis 5 0.0052464
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0052459
UBN2 ubinuclein 2 0.00517751
FGF18 fibroblast growth factor 18 0.00499472
SIRT1 sirtuin 1 0.00484208
DUSP16 dual specificity phosphatase 16 0.00484002
NPTN neuroplastin 0.00480818
ABLIM1 actin binding LIM protein 1 0.00480763
CNIH3 cornichon family AMPA receptor auxiliary protein 3 0.00475871
DCAF6 DDB1 and CUL4 associated factor 6 0.00475468
GLS2 glutaminase 2 (liver, mitochondrial) 0.00472886
RCOR1 REST corepressor 1 0.00472769
HOMER1 homer scaffolding protein 1 0.00472237
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.00471778
MBD5 methyl-CpG binding domain protein 5 0.00466806
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.00457856
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.00457648
FERMT2 fermitin family member 2 0.00453901
ATF6 activating transcription factor 6 0.00453084
NLK nemo-like kinase 0.00447444
BICD1 bicaudal D homolog 1 (Drosophila) 0.00447346
SMOC1 SPARC related modular calcium binding 1 0.00445286
MCTP1 multiple C2 domains, transmembrane 1 0.00444464
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.00444407
EFCAB13 EF-hand calcium binding domain 13 0.00442686
LMO7 LIM domain 7 0.0043804
NALF1 NALCN channel auxiliary factor 1 0.004372
DENND1A DENN/MADD domain containing 1A 0.00433574
ADIPOR2 adiponectin receptor 2 0.00424192
NOVA1 neuro-oncological ventral antigen 1 0.00421949
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.00420442
CDK14 cyclin-dependent kinase 14 0.00415953
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0041382
TIAM2 T-cell lymphoma invasion and metastasis 2 0.00411422
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.00411168
TRPS1 trichorhinophalangeal syndrome I 0.00409224
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.00406011
PDLIM5 PDZ and LIM domain 5 0.00404512
GPC5 glypican 5 0.00404065
EXOC4 exocyst complex component 4 0.00404055
MTSS1 metastasis suppressor 1 0.00402076
SHOC2 soc-2 suppressor of clear homolog (C. elegans) 0.00400786
ADAM20 ADAM metallopeptidase domain 20 0.00397271
RANBP17 RAN binding protein 17 0.00395176
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.00394579
SLC35F3 solute carrier family 35, member F3 0.00394454
GMDS GDP-mannose 4,6-dehydratase 0.00393745
UBE3C ubiquitin protein ligase E3C 0.00392808
ERO1B endoplasmic reticulum oxidoreductase 1 beta 0.00391738
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.00391009
FLRT2 fibronectin leucine rich transmembrane protein 2 0.0039049
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.00388545
STRN3 striatin, calmodulin binding protein 3 0.00388371
TTC19 tetratricopeptide repeat domain 19 0.00388359

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.180185
FN1 fibronectin 1 -0.1079
MT2A metallothionein 2A -0.0720555
PTMA prothymosin, alpha -0.0704901
FTL ferritin, light polypeptide -0.0608644
TMSB10 thymosin beta 10 -0.0585418
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0578994
B2M beta-2-microglobulin -0.0552172
HLA-B major histocompatibility complex, class I, B -0.0547175
VIM vimentin -0.0511159
NAMPT nicotinamide phosphoribosyltransferase -0.0510616
SQSTM1 sequestosome 1 -0.0466945
S100A6 S100 calcium binding protein A6 -0.0458353
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0450408
ASPH aspartate beta-hydroxylase -0.0447446
NDRG1 N-myc downstream regulated 1 -0.0419595
CANX calnexin -0.0418973
IFI27 interferon, alpha-inducible protein 27 -0.0411027
SFTPA2 surfactant protein A2 -0.039828
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0382104
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0337875
PKM pyruvate kinase, muscle -0.0332201
STC2 stanniocalcin 2 -0.0319162
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0315193
PRRC2C proline-rich coiled-coil 2C -0.0299937
RPS6 ribosomal protein S6 -0.0298326
TMSB4X thymosin beta 4, X-linked -0.0296468
FTH1 ferritin, heavy polypeptide 1 -0.0295263
TXNIP thioredoxin interacting protein -0.0284696
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0279607
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0271687
ENO1 enolase 1, (alpha) -0.0267075
RACK1 receptor for activated C kinase 1 -0.026671
MYH9 myosin, heavy chain 9, non-muscle -0.0262696
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0258162
TPI1 triosephosphate isomerase 1 -0.0253715
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0253342
TPT1 tumor protein, translationally-controlled 1 -0.0252492
TMEM156 transmembrane protein 156 -0.0239401
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.023724
RPS12 ribosomal protein S12 -0.0233271
RPS19 ribosomal protein S19 -0.0231863
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0231134
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.022917
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0228713
IFI6 interferon, alpha-inducible protein 6 -0.0226648
AKAP12 A kinase (PRKA) anchor protein 12 -0.0223048
SOX4 SRY (sex determining region Y)-box 4 -0.0216994
LOC112694756 uncharaterized LOC112694756 -0.0215848
CALR calreticulin -0.0214312
PGK1 phosphoglycerate kinase 1 -0.0212758
RPL35A ribosomal protein L35a -0.0211203
RPS27 ribosomal protein S27 -0.0210116
HLA-A major histocompatibility complex, class I, A -0.0205464
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0205228
RPL31 ribosomal protein L31 -0.0203854
OSMR oncostatin M receptor -0.0200334
S100A10 S100 calcium binding protein A10 -0.0200225
RPL12 ribosomal protein L12 -0.0199514
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0199096
RPL26 ribosomal protein L26 -0.0198295
RPLP1 ribosomal protein, large, P1 -0.0195082
HMGA1 high mobility group AT-hook 1 -0.0194408
RPL23 ribosomal protein L23 -0.0193988
MAP1B microtubule-associated protein 1B -0.0193538
RPL37A ribosomal protein L37a -0.0191894
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0191109
LOC102724023 ES1 protein homolog, mitochondrial -0.0190566
AHNAK AHNAK nucleoprotein -0.0185965
CAPN2 calpain 2, (m/II) large subunit -0.0182266
PLIN2 perilipin 2 -0.0181976
LMNA lamin A/C -0.0180828
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0177112
TXNRD1 thioredoxin reductase 1 -0.0176682
PELO pelota homolog (Drosophila) -0.0175042
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0172531
KLHL5 kelch-like family member 5 -0.0172014
ENO2 enolase 2 (gamma, neuronal) -0.0171875
MKI67 marker of proliferation Ki-67 -0.0165757
IFI16 interferon, gamma-inducible protein 16 -0.01652
HIPK2 homeodomain interacting protein kinase 2 -0.0163821
CD63 CD63 molecule -0.0163742
IER3 immediate early response 3 -0.0163091
EIF1 eukaryotic translation initiation factor 1 -0.0158213
RPL9 ribosomal protein L9 -0.0157121
VEGFA vascular endothelial growth factor A -0.0156497
RPS8 ribosomal protein S8 -0.0154732
RPS3 ribosomal protein S3 -0.0154501
ITGA1 integrin, alpha 1 -0.0151177
LDHA lactate dehydrogenase A -0.0149984
RPL36 ribosomal protein L36 -0.0147075
ACTN4 actinin, alpha 4 -0.014621
RTN4 reticulon 4 -0.0144631
NRP1 neuropilin 1 -0.0141544
GOLGA4 golgin A4 -0.014146
KPNB1 karyopherin (importin) beta 1 -0.0141232
CD44 CD44 molecule (Indian blood group) -0.0141036
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0139598
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0139448
TPM4 tropomyosin 4 -0.0138482