9-ING-41_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 9-ING-41 perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 9-ING-41_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.239652
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.233569
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.192593
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.13076
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.108399
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.100288
NLGN1 neuroligin 1 0.0970772
HMGA2 high mobility group AT-hook 2 0.0927974
ACTG1 actin gamma 1 0.0780227
RPS12 ribosomal protein S12 0.0720211
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0673329
PDE4D phosphodiesterase 4D, cAMP-specific 0.0650881
AREG amphiregulin 0.063363
ANXA1 annexin A1 0.0557734
RPS8 ribosomal protein S8 0.052958
RPS6 ribosomal protein S6 0.0522196
RPS3 ribosomal protein S3 0.0519018
TPT1 tumor protein, translationally-controlled 1 0.0502392
RAB7A RAB7A, member RAS oncogene family 0.0500774
ANKRD12 ankyrin repeat domain 12 0.0493872
JMJD1C jumonji domain containing 1C 0.0486289
PCDH7 protocadherin 7 0.0474833
TMSB10 thymosin beta 10 0.0459023
EIF1 eukaryotic translation initiation factor 1 0.044922
ZSWIM6 zinc finger, SWIM-type containing 6 0.0448962
YAP1 Yes-associated protein 1 0.0438272
TENM3 teneurin transmembrane protein 3 0.0428998
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0426234
VMP1 vacuole membrane protein 1 0.0402743
BIRC3 baculoviral IAP repeat containing 3 0.0392212
RPL37A ribosomal protein L37a 0.0388953
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.0375975
NAP1L1 nucleosome assembly protein 1-like 1 0.0375926
ENO1 enolase 1, (alpha) 0.0374029
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0373381
PRDX1 peroxiredoxin 1 0.0363198
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0362281
ADIPOR2 adiponectin receptor 2 0.0360244
FTL ferritin, light polypeptide 0.0353546
RPL23 ribosomal protein L23 0.0349779
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0349509
MMP12 matrix metallopeptidase 12 0.0348174
GJA1 gap junction protein, alpha 1, 43kDa 0.0345291
RPS23 ribosomal protein S23 0.034492
EHBP1 EH domain binding protein 1 0.0342832
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0328295
RPL37 ribosomal protein L37 0.0323954
HDAC9 histone deacetylase 9 0.0323879
DPYD dihydropyrimidine dehydrogenase 0.0322189
RACK1 receptor for activated C kinase 1 0.0321283
RPS29 ribosomal protein S29 0.0320888
EEF2 eukaryotic translation elongation factor 2 0.0319821
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0313206
RPS2 ribosomal protein S2 0.0311371
RIMS2 regulating synaptic membrane exocytosis 2 0.029939
MSRB3 methionine sulfoxide reductase B3 0.0288665
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0285436
LOC102724023 ES1 protein homolog, mitochondrial 0.0279861
RPS27A ribosomal protein S27a 0.0279653
CNRIP1 cannabinoid receptor interacting protein 1 0.027879
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0277217
LPP LIM domain containing preferred translocation partner in lipoma 0.0271043
POTEF POTE ankyrin domain family, member F 0.0269974
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0268526
INTS6 integrator complex subunit 6 0.0259001
RRM2 ribonucleotide reductase M2 0.0258137
NEGR1 neuronal growth regulator 1 0.0258093
BPTF bromodomain PHD finger transcription factor 0.0256271
MKI67 marker of proliferation Ki-67 0.0254481
CALR calreticulin 0.0251415
RPS13 ribosomal protein S13 0.0251359
RPL26 ribosomal protein L26 0.025131
PDGFC platelet derived growth factor C 0.0248417
RPS19 ribosomal protein S19 0.024573
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0243984
RPL19 ribosomal protein L19 0.0240979
RPLP2 ribosomal protein, large, P2 0.0238603
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0235699
ARID1B AT rich interactive domain 1B (SWI1-like) 0.023569
IPO7 importin 7 0.023443
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0229623
DST dystonin 0.0229451
RPL12 ribosomal protein L12 0.0228846
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.022594
HSPB1 heat shock 27kDa protein 1 0.0222195
CANX calnexin 0.0221484
SLC38A2 solute carrier family 38, member 2 0.0219966
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0218363
EPHA5 EPH receptor A5 0.0218139
RPS27 ribosomal protein S27 0.0216528
RPL31 ribosomal protein L31 0.0215834
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0212028
DLC1 DLC1 Rho GTPase activating protein 0.0211788
RPL34 ribosomal protein L34 0.0211295
WWOX WW domain containing oxidoreductase 0.0209884
BCHE butyrylcholinesterase 0.0209101
RPL9 ribosomal protein L9 0.0208629
ASPH aspartate beta-hydroxylase 0.0206799
ERBIN erbb2 interacting protein 0.0204933
SQSTM1 sequestosome 1 0.0204042

decreased expression

Symbol Name Standardized Value
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0361671
CCNL1 cyclin L1 -0.0245857
ATP5F1B ATP synthase F1 subunit beta -0.023735
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0233498
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0180076
GARS1 glycyl-tRNA synthetase 1 -0.0178569
CXADR coxsackie virus and adenovirus receptor -0.0170129
THOC2 THO complex 2 -0.0167845
CDK17 cyclin-dependent kinase 17 -0.0167023
KDM3A lysine (K)-specific demethylase 3A -0.0159431
H1-0 H1.0 linker histone -0.0156587
LMO7 LIM domain 7 -0.0151881
NCOR1 nuclear receptor corepressor 1 -0.0150639
ECT2 epithelial cell transforming 2 -0.0145918
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0145512
BIRC6 baculoviral IAP repeat containing 6 -0.0144509
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0138725
TMEM131 transmembrane protein 131 -0.0130246
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0129313
WDR43 WD repeat domain 43 -0.0128433
ADAM9 ADAM metallopeptidase domain 9 -0.0127449
ZNF292 zinc finger protein 292 -0.012709
RAD21 RAD21 homolog (S. pombe) -0.0126807
ADGRG6 adhesion G protein-coupled receptor G6 -0.0126088
BRWD3 bromodomain and WD repeat domain containing 3 -0.0125591
MARCHF6 membrane associated ring-CH-type finger 6 -0.0119095
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.011832
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0117925
AXIN2 axin 2 -0.0115963
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0115588
COG5 component of oligomeric golgi complex 5 -0.0111135
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0110472
XPO1 exportin 1 -0.0108167
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0107317
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0106489
HLA-A major histocompatibility complex, class I, A -0.0106138
MON2 MON2 homolog (S. cerevisiae) -0.0106115
OGA O-GlcNAcase -0.0105913
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0105663
PCBP2 poly(rC) binding protein 2 -0.0104305
U2SURP U2 snRNP-associated SURP domain containing -0.0104139
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0103759
GRB2 growth factor receptor-bound protein 2 -0.0102611
THOC1 THO complex 1 -0.0101943
NUP58 nucleoporin 58 -0.0100442
MARS1 methionyl-tRNA synthetase 1 -0.0100177
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.00997621
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.00995658
RBM27 RNA binding motif protein 27 -0.00986335
CDK19 cyclin-dependent kinase 19 -0.00970645
GMPS guanine monphosphate synthase -0.00969758
TIGAR TP53 induced glycolysis regulatory phosphatase -0.00966798
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.00961375
MDN1 MDN1, midasin homolog (yeast) -0.00951143
SPRED2 sprouty-related, EVH1 domain containing 2 -0.00944904
HEATR1 HEAT repeat containing 1 -0.00942356
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 -0.00940324
FAM3C family with sequence similarity 3, member C -0.00931707
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.00919142
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.00916893
R3HDM1 R3H domain containing 1 -0.00915628
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.00913855
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.00905401
CKAP5 cytoskeleton associated protein 5 -0.00900452
USP3 ubiquitin specific peptidase 3 -0.00895183
ARHGAP12 Rho GTPase activating protein 12 -0.00892048
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.00879354
DDB2 damage-specific DNA binding protein 2, 48kDa -0.00868306
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.00862652
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -0.00856883
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.00852855
PAWR PRKC, apoptosis, WT1, regulator -0.00847428
BLTP2 bridge-like lipid transfer protein family member 2 -0.00844247
ZFAND6 zinc finger, AN1-type domain 6 -0.00842601
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.00841699
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.00834478
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -0.00834406
CCNG1 cyclin G1 -0.0083331
MSI2 musashi RNA-binding protein 2 -0.00829334
FAR1 fatty acyl CoA reductase 1 -0.00828254
PCNP PEST proteolytic signal containing nuclear protein -0.00824924
TENT4A terminal nucleotidyltransferase 4A -0.00823315
NEMF nuclear export mediator factor -0.00822489
KIF5B kinesin family member 5B -0.00820178
NCK1 NCK adaptor protein 1 -0.00817119
CDCA2 cell division cycle associated 2 -0.00812548
OXR1 oxidation resistance 1 -0.00810743
ELF2 E74-like factor 2 (ets domain transcription factor) -0.00802972
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -0.00801125
GNA13 guanine nucleotide binding protein (G protein), alpha 13 -0.00799918
TBC1D23 TBC1 domain family, member 23 -0.0079711
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -0.00791398
TSC22D2 TSC22 domain family, member 2 -0.00788952
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -0.00787257
NOLC1 nucleolar and coiled-body phosphoprotein 1 -0.0078678
NKTR natural killer cell triggering receptor -0.00784583
CASC3 cancer susceptibility candidate 3 -0.00779898
IPMK inositol polyphosphate multikinase -0.00774487
GGNBP2 gametogenetin binding protein 2 -0.00772635
PNN pinin, desmosome associated protein -0.00769495