| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | 9-ING-41 perturbation in BT-474 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the 9-ING-41_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPL19 | ribosomal protein L19 | 0.118153 |
| CLTC | clathrin, heavy chain (Hc) | 0.111906 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0927334 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0877055 |
| RPS3 | ribosomal protein S3 | 0.0813453 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0787786 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0768687 |
| VMP1 | vacuole membrane protein 1 | 0.0757244 |
| SET | SET nuclear proto-oncogene | 0.0753293 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0704905 |
| DYNLRB1 | dynein, light chain, roadblock-type 1 | 0.06291 |
| MT2A | metallothionein 2A | 0.0616554 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0603036 |
| DUSP16 | dual specificity phosphatase 16 | 0.0590933 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0584141 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.055022 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0485431 |
| DSPP | dentin sialophosphoprotein | 0.0476643 |
| RPL23 | ribosomal protein L23 | 0.046717 |
| RAB22A | RAB22A, member RAS oncogene family | 0.0462979 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0442687 |
| TENM2 | teneurin transmembrane protein 2 | 0.042592 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0416991 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0403898 |
| ENAH | enabled homolog (Drosophila) | 0.0401246 |
| ZNF292 | zinc finger protein 292 | 0.0394261 |
| UNC13B | unc-13 homolog B (C. elegans) | 0.0394202 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0353084 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0341537 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0337405 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0333833 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0329437 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0327882 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0323525 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0317718 |
| VAV3 | vav 3 guanine nucleotide exchange factor | 0.0313958 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0306275 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0304351 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0302743 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0301233 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.030017 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0297506 |
| CCNI | cyclin I | 0.0297412 |
| B2M | beta-2-microglobulin | 0.0295673 |
| ENO1 | enolase 1, (alpha) | 0.0290959 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0290373 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0288599 |
| S100P | S100 calcium binding protein P | 0.0286988 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.028591 |
| RPL18 | ribosomal protein L18 | 0.0284805 |
| SON | SON DNA binding protein | 0.0279834 |
| NTN4 | netrin 4 | 0.0278862 |
| RPS2 | ribosomal protein S2 | 0.0271298 |
| BPTF | bromodomain PHD finger transcription factor | 0.0265365 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0263212 |
| PNN | pinin, desmosome associated protein | 0.0261807 |
| RPL12 | ribosomal protein L12 | 0.0259697 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0255678 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0254365 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0252622 |
| KLHL24 | kelch-like family member 24 | 0.0250513 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0250445 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0249798 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | 0.024245 |
| JAK1 | Janus kinase 1 | 0.0240883 |
| SGMS1 | sphingomyelin synthase 1 | 0.0240539 |
| RPL7 | ribosomal protein L7 | 0.0237074 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0236096 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0234885 |
| RAI1 | retinoic acid induced 1 | 0.0232474 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0231968 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0231611 |
| PLK2 | polo-like kinase 2 | 0.0231448 |
| NDUFA4 | NDUFA4, mitochondrial complex associated | 0.0231307 |
| GOLGA4 | golgin A4 | 0.0230536 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0230501 |
| PCBP2 | poly(rC) binding protein 2 | 0.0230349 |
| DTNA | dystrobrevin, alpha | 0.0228716 |
| YAP1 | Yes-associated protein 1 | 0.0226412 |
| ZBTB43 | zinc finger and BTB domain containing 43 | 0.0225225 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0225084 |
| POTEF | POTE ankyrin domain family, member F | 0.0224555 |
| LDHA | lactate dehydrogenase A | 0.0224325 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.022175 |
| MTPN | myotrophin | 0.0219955 |
| MED13L | mediator complex subunit 13-like | 0.0218235 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0215866 |
| UBC | ubiquitin C | 0.0215523 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0214027 |
| TPD52 | tumor protein D52 | 0.0213909 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0213647 |
| NRP1 | neuropilin 1 | 0.0213366 |
| TPM3 | tropomyosin 3 | 0.0212165 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0210316 |
| MYO1B | myosin IB | 0.0209706 |
| TXNRD1 | thioredoxin reductase 1 | 0.0209209 |
| ABHD17C | abhydrolase domain containing 17C | 0.0209074 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0208149 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0206928 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | 0.0204546 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.204114 |
| PTMA | prothymosin, alpha | -0.177549 |
| CDK12 | cyclin-dependent kinase 12 | -0.111157 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | -0.105765 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0922885 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0911289 |
| CEP250 | centrosomal protein 250kDa | -0.0821726 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.081431 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.08036 |
| LASP1 | LIM and SH3 protein 1 | -0.0768547 |
| RPL35A | ribosomal protein L35a | -0.0622424 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0595382 |
| FDPS | farnesyl diphosphate synthase | -0.0586565 |
| MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | -0.0571104 |
| ASPH | aspartate beta-hydroxylase | -0.0567117 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | -0.0566445 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0520518 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0512511 |
| RPS24 | ribosomal protein S24 | -0.0462397 |
| CCND1 | cyclin D1 | -0.045607 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0445301 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0427344 |
| TMSB4X | thymosin beta 4, X-linked | -0.0425694 |
| MCL1 | myeloid cell leukemia 1 | -0.0418546 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0407053 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0395121 |
| DENND1A | DENN/MADD domain containing 1A | -0.0394694 |
| EGR1 | early growth response 1 | -0.0361924 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.034975 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | -0.0345078 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0311294 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0309633 |
| HMGB1 | high mobility group box 1 | -0.0296386 |
| INTS6 | integrator complex subunit 6 | -0.0291765 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0291254 |
| LMNA | lamin A/C | -0.0284933 |
| PKM | pyruvate kinase, muscle | -0.0283514 |
| RPL27A | ribosomal protein L27a | -0.0279605 |
| RPLP1 | ribosomal protein, large, P1 | -0.0279397 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0276001 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0273275 |
| TPM4 | tropomyosin 4 | -0.027231 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0272239 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0269799 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.026659 |
| TNS3 | tensin 3 | -0.0266533 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | -0.0266356 |
| RBM47 | RNA binding motif protein 47 | -0.0265613 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.025861 |
| KRT18 | keratin 18, type I | -0.0254382 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0249099 |
| IL1RAPL2 | interleukin 1 receptor accessory protein-like 2 | -0.0247244 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0243743 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.024039 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0240226 |
| FADS2 | fatty acid desaturase 2 | -0.0240174 |
| RPL38 | ribosomal protein L38 | -0.0239724 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0238398 |
| IER3 | immediate early response 3 | -0.0238283 |
| FASN | fatty acid synthase | -0.0237053 |
| ACTN4 | actinin, alpha 4 | -0.0236482 |
| PRRC2B | proline-rich coiled-coil 2B | -0.023458 |
| F11R | F11 receptor | -0.0233587 |
| RPS13 | ribosomal protein S13 | -0.0233411 |
| AGR2 | anterior gradient 2 | -0.0232687 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -0.0230045 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0227698 |
| RNF213 | ring finger protein 213 | -0.0225377 |
| SNX14 | sorting nexin 14 | -0.0223286 |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | -0.0223233 |
| CDH15 | cadherin 15, type 1, M-cadherin (myotubule) | -0.0222783 |
| VCL | vinculin | -0.0221652 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.022127 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0219758 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.0219426 |
| HLA-C | major histocompatibility complex, class I, C | -0.021871 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0218533 |
| TMSB10 | thymosin beta 10 | -0.0212772 |
| VIM | vimentin | -0.0208408 |
| ADIPOR2 | adiponectin receptor 2 | -0.0207589 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | -0.0207203 |
| TFRC | transferrin receptor | -0.0206581 |
| POLD3 | polymerase (DNA-directed), delta 3, accessory subunit | -0.0205178 |
| TENM4 | teneurin transmembrane protein 4 | -0.0200063 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0199318 |
| STXBP1 | syntaxin binding protein 1 | -0.01993 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0199057 |
| RPS16 | ribosomal protein S16 | -0.0198377 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0197899 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0197711 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0196735 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0196198 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0195422 |
| PARD3 | par-3 family cell polarity regulator | -0.0195369 |
| ZNF652 | zinc finger protein 652 | -0.0195366 |
| RRM2 | ribonucleotide reductase M2 | -0.0194238 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0194192 |
| GNAS | GNAS complex locus | -0.0192176 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0191107 |
| CUEDC1 | CUE domain containing 1 | -0.0189222 |
