9-ING-41_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 9-ING-41 perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 9-ING-41_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FMN1 formin 1 0.205453
VCL vinculin 0.134275
TLE4 transducin-like enhancer of split 4 0.124876
ZSWIM6 zinc finger, SWIM-type containing 6 0.110532
EXT1 exostosin glycosyltransferase 1 0.0955754
TPST1 tyrosylprotein sulfotransferase 1 0.0846933
ACTG1 actin gamma 1 0.0832739
SLIT2 slit homolog 2 (Drosophila) 0.0668287
EIF1 eukaryotic translation initiation factor 1 0.0648788
TPT1 tumor protein, translationally-controlled 1 0.0634596
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0632787
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0615637
RIGI RNA sensor RIG-I 0.0581683
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0577932
MYO6 myosin VI 0.0572715
EEF2 eukaryotic translation elongation factor 2 0.0548956
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0536547
FNDC3A fibronectin type III domain containing 3A 0.0530227
PLAT plasminogen activator, tissue 0.0527423
BPTF bromodomain PHD finger transcription factor 0.0513557
GLCCI1 glucocorticoid induced 1 0.0508048
RPS6 ribosomal protein S6 0.0498599
RPS12 ribosomal protein S12 0.0488582
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.046381
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0452748
RPS3 ribosomal protein S3 0.0451882
LPP LIM domain containing preferred translocation partner in lipoma 0.0442889
RPL23 ribosomal protein L23 0.0433256
SLC38A2 solute carrier family 38, member 2 0.0427463
KLHL13 kelch-like family member 13 0.0416496
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0403381
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0398697
GPATCH8 G patch domain containing 8 0.0398572
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0387619
INTS6 integrator complex subunit 6 0.0380713
PTPRK protein tyrosine phosphatase, receptor type, K 0.0374224
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0373997
GAB2 GRB2-associated binding protein 2 0.0373075
VMP1 vacuole membrane protein 1 0.0360752
PLPP1 phospholipid phosphatase 1 0.0351152
SIK2 salt-inducible kinase 2 0.0347799
RPL26 ribosomal protein L26 0.0347428
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0346239
MRTFA myocardin related transcription factor A 0.03376
PRRC2C proline-rich coiled-coil 2C 0.03214
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.03192
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0317834
ANTXR1 anthrax toxin receptor 1 0.0316524
FAM107B family with sequence similarity 107, member B 0.0310214
DGKH diacylglycerol kinase, eta 0.0309811
RPL37A ribosomal protein L37a 0.030822
ITGA1 integrin, alpha 1 0.03079
CSNK1A1 casein kinase 1, alpha 1 0.0305465
FERMT2 fermitin family member 2 0.0305465
MX2 MX dynamin-like GTPase 2 0.0304854
MED13 mediator complex subunit 13 0.0298804
STK38L serine/threonine kinase 38 like 0.0293343
SP100 SP100 nuclear antigen 0.029209
TPM4 tropomyosin 4 0.028997
RAP1B RAP1B, member of RAS oncogene family 0.0289231
NPAS2 neuronal PAS domain protein 2 0.028866
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0288148
PDE10A phosphodiesterase 10A 0.0284603
SQSTM1 sequestosome 1 0.0283248
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0282852
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0280579
SYNPO2 synaptopodin 2 0.0279944
FLT1 fms-related tyrosine kinase 1 0.0279309
AHR aryl hydrocarbon receptor 0.027796
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0276284
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0274951
TRIO trio Rho guanine nucleotide exchange factor 0.0273474
RAB7A RAB7A, member RAS oncogene family 0.0272767
BICD1 bicaudal D homolog 1 (Drosophila) 0.0271983
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0271613
THSD4 thrombospondin, type I, domain containing 4 0.026628
RPS8 ribosomal protein S8 0.0264336
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0256348
MYO1E myosin IE 0.0255667
RPS17 ribosomal protein S17 0.0253349
RPS2 ribosomal protein S2 0.025175
PACS1 phosphofurin acidic cluster sorting protein 1 0.0248956
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0248535
AMOTL1 angiomotin like 1 0.024809
NRIP1 nuclear receptor interacting protein 1 0.0247202
TIMP3 TIMP metallopeptidase inhibitor 3 0.0247013
BCAS3 breast carcinoma amplified sequence 3 0.0246997
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0246359
ITPKB inositol-trisphosphate 3-kinase B 0.0245864
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0244883
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0241308
PDLIM5 PDZ and LIM domain 5 0.0239016
EXOC6B exocyst complex component 6B 0.0235469
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0235099
UBAP2 ubiquitin associated protein 2 0.0234622
RND3 Rho family GTPase 3 0.0233335
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0230227
IER3 immediate early response 3 0.0227036
TPM1 tropomyosin 1 (alpha) 0.0226384
RCOR1 REST corepressor 1 0.0226176

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.334959
LSAMP limbic system-associated membrane protein -0.0774723
PTMA prothymosin, alpha -0.0666131
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0561511
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.053701
NCAM2 neural cell adhesion molecule 2 -0.0521551
FAM13A family with sequence similarity 13, member A -0.0511398
MEF2A myocyte enhancer factor 2A -0.0471716
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.045828
NREP neuronal regeneration related protein -0.0435922
TRIB2 tribbles pseudokinase 2 -0.0413899
NDRG1 N-myc downstream regulated 1 -0.0410473
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0407937
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0406688
NPEPPS aminopeptidase puromycin sensitive -0.040436
CRH corticotropin releasing hormone -0.0398512
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.038846
MAP1B microtubule-associated protein 1B -0.0387241
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0369601
PKM pyruvate kinase, muscle -0.036263
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0361493
P4HB prolyl 4-hydroxylase, beta polypeptide -0.035752
FNBP1 formin binding protein 1 -0.0356611
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0349288
MSI2 musashi RNA-binding protein 2 -0.0342542
SETD5 SET domain containing 5 -0.0337618
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0324824
COPA coatomer protein complex, subunit alpha -0.0318532
COL1A1 collagen, type I, alpha 1 -0.0313007
GOLGA4 golgin A4 -0.0309736
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0297061
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0290971
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0289934
LIMCH1 LIM and calponin homology domains 1 -0.028951
WDR45B WD repeat domain 45B -0.0286282
RPTOR regulatory associated protein of MTOR, complex 1 -0.027711
GARS1 glycyl-tRNA synthetase 1 -0.0267875
TMSB10 thymosin beta 10 -0.0266175
CANX calnexin -0.0265848
TOX thymocyte selection-associated high mobility group box -0.0265463
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0261162
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0256159
RNF150 ring finger protein 150 -0.0255668
CADM2 cell adhesion molecule 2 -0.0252669
IGFBP3 insulin-like growth factor binding protein 3 -0.0251899
VEGFA vascular endothelial growth factor A -0.0251811
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0249409
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 -0.0248033
PHF3 PHD finger protein 3 -0.0243011
HDLBP high density lipoprotein binding protein -0.0242697
RBM20 RNA binding motif protein 20 -0.0242102
TOB1 transducer of ERBB2, 1 -0.0241368
HELZ helicase with zinc finger -0.0234902
PLCB4 phospholipase C, beta 4 -0.0233571
DTNA dystrobrevin, alpha -0.0232444
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -0.0228598
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0228414
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 -0.0224752
C1ORF21 chromosome 1 open reading frame 21 -0.0222226
PDIA3 protein disulfide isomerase family A, member 3 -0.0219506
PTPRD protein tyrosine phosphatase, receptor type, D -0.0219216
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0219115
MBNL2 muscleblind-like splicing regulator 2 -0.0215644
TENT5A terminal nucleotidyltransferase 5A -0.0212299
FAM162A family with sequence similarity 162, member A -0.0210835
KDM5B lysine (K)-specific demethylase 5B -0.0207636
NCOR2 nuclear receptor corepressor 2 -0.0207294
PRKCA protein kinase C, alpha -0.0206103
CD46 CD46 molecule, complement regulatory protein -0.0203919
IARS1 isoleucyl-tRNA synthetase 1 -0.0202683
INSIG2 insulin induced gene 2 -0.0198086
PRTG protogenin -0.0197196
LRRC7 leucine rich repeat containing 7 -0.0195713
ACBD3 acyl-CoA binding domain containing 3 -0.0194391
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0192846
AUH AU RNA binding protein/enoyl-CoA hydratase -0.0192762
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0191837
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0190715
SMIM44 small integral membrane protein 44 -0.0189917
MTSS2 MTSS I-BAR domain containing 2 -0.01896
ASPH aspartate beta-hydroxylase -0.0188139
RTN4 reticulon 4 -0.0187562
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0185963
PTPRM protein tyrosine phosphatase, receptor type, M -0.0183017
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog -0.0182646
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0181768
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0180236
RARA retinoic acid receptor, alpha -0.0179638
MYLK myosin light chain kinase -0.0179294
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0179123
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.017877
LMNA lamin A/C -0.017732
ARID3A AT rich interactive domain 3A (BRIGHT-like) -0.0174227
AFF4 AF4/FMR2 family, member 4 -0.0174097
RNF145 ring finger protein 145 -0.0173681
GRB2 growth factor receptor-bound protein 2 -0.0173635
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19 -0.0172405
TNRC6B trinucleotide repeat containing 6B -0.0170877
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 -0.0170591
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.017027