9-ING-41_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 9-ING-41 perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 9-ING-41_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.218114
KYNU kynureninase 0.105477
STC1 stanniocalcin 1 0.0894353
SQSTM1 sequestosome 1 0.0814313
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0764691
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0741829
EEF2 eukaryotic translation elongation factor 2 0.0650084
TPT1 tumor protein, translationally-controlled 1 0.0540345
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0508327
UBC ubiquitin C 0.0470864
HDAC9 histone deacetylase 9 0.0464044
NALF1 NALCN channel auxiliary factor 1 0.0446007
DGKI diacylglycerol kinase, iota 0.0424087
GLCCI1 glucocorticoid induced 1 0.040763
RPS27A ribosomal protein S27a 0.0401256
RACK1 receptor for activated C kinase 1 0.0390286
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.038474
RPL37A ribosomal protein L37a 0.0382258
NAP1L1 nucleosome assembly protein 1-like 1 0.0370837
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 0.0363199
MT2A metallothionein 2A 0.0355726
RPS8 ribosomal protein S8 0.0355126
RPS12 ribosomal protein S12 0.035084
CEMIP cell migration inducing protein, hyaluronan binding 0.034968
FGF13 fibroblast growth factor 13 0.03331
RPL37 ribosomal protein L37 0.0330318
FNIP1 folliculin interacting protein 1 0.0315341
CTSB cathepsin B 0.0306143
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0305337
RPL23 ribosomal protein L23 0.0304784
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) 0.0304657
INTS6 integrator complex subunit 6 0.0303856
FLRT2 fibronectin leucine rich transmembrane protein 2 0.0302697
RPS6 ribosomal protein S6 0.0294252
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0288412
RPL12 ribosomal protein L12 0.0278975
ENO1 enolase 1, (alpha) 0.0276324
HMGA2 high mobility group AT-hook 2 0.0263563
NFE2L1 nuclear factor, erythroid 2-like 1 0.0257173
RPS3 ribosomal protein S3 0.0250455
HIP1 huntingtin interacting protein 1 0.0249071
RPL5 ribosomal protein L5 0.0244449
LIMS1 LIM and senescent cell antigen-like domains 1 0.0242598
PHF3 PHD finger protein 3 0.0241602
APLP2 amyloid beta (A4) precursor-like protein 2 0.0241446
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0238058
PCLO piccolo presynaptic cytomatrix protein 0.0236403
UBAP2 ubiquitin associated protein 2 0.0236216
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0236167
RPL13A ribosomal protein L13a 0.0234739
PDIA6 protein disulfide isomerase family A, member 6 0.0232289
ANTXR1 anthrax toxin receptor 1 0.0231963
SLC39A11 solute carrier family 39, member 11 0.0229188
OGA O-GlcNAcase 0.022897
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0224916
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0224483
RPS2 ribosomal protein S2 0.021876
CALN1 calneuron 1 0.0216104
BBS9 Bardet-Biedl syndrome 9 0.0216076
PLAGL1 pleiomorphic adenoma gene-like 1 0.0214677
ARB2A ARB2 cotranscriptional regulator A 0.0214647
RIMS2 regulating synaptic membrane exocytosis 2 0.0210192
MCTP1 multiple C2 domains, transmembrane 1 0.0210148
SFTPA2 surfactant protein A2 0.0209356
ZSWIM6 zinc finger, SWIM-type containing 6 0.0207516
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.0200251
PRKG1 protein kinase, cGMP-dependent, type I 0.0197602
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0197089
SET SET nuclear proto-oncogene 0.0196554
SCAPER S-phase cyclin A-associated protein in the ER 0.0196498
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.019329
RPL31 ribosomal protein L31 0.0192568
RPS17 ribosomal protein S17 0.0189704
EIF1 eukaryotic translation initiation factor 1 0.018904
RPL11 ribosomal protein L11 0.018898
STXBP1 syntaxin binding protein 1 0.0188698
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0188197
AHR aryl hydrocarbon receptor 0.01846
TIAM1 T-cell lymphoma invasion and metastasis 1 0.0182247
RPL4 ribosomal protein L4 0.0180655
RPL26 ribosomal protein L26 0.0178867
RND3 Rho family GTPase 3 0.0178553
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0175609
AEBP2 AE binding protein 2 0.0175602
RPS13 ribosomal protein S13 0.0175548
KTN1 kinectin 1 (kinesin receptor) 0.0169713
RPS23 ribosomal protein S23 0.0168464
RPS16 ribosomal protein S16 0.0166327
CFAP96 cilia and flagella associated protein 96 0.0166155
SUMF1 sulfatase modifying factor 1 0.0165227
DOCK7 dedicator of cytokinesis 7 0.0164581
PDIA4 protein disulfide isomerase family A, member 4 0.0163002
RPL7 ribosomal protein L7 0.0162628
ITGA1 integrin, alpha 1 0.0162374
N4BP2L2 NEDD4 binding protein 2-like 2 0.0161387
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0159664
CCNI cyclin I 0.0159044
ANK2 ankyrin 2, neuronal 0.0154988
RPLP0 ribosomal protein, large, P0 0.0152406
ZBTB1 zinc finger and BTB domain containing 1 0.0148055

decreased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 -0.249513
TMSB10 thymosin beta 10 -0.151075
CXCL8 chemokine (C-X-C motif) ligand 8 -0.110129
FN1 fibronectin 1 -0.108435
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.107356
MAP1B microtubule-associated protein 1B -0.106456
GRB10 growth factor receptor-bound protein 10 -0.101938
EGFR epidermal growth factor receptor -0.10158
DST dystonin -0.0994574
TRIO trio Rho guanine nucleotide exchange factor -0.0980931
SBF2 SET binding factor 2 -0.0970614
RTN4 reticulon 4 -0.0961078
GARS1 glycyl-tRNA synthetase 1 -0.0933955
TPM4 tropomyosin 4 -0.091758
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0877807
EXT1 exostosin glycosyltransferase 1 -0.0862736
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0789912
OSMR oncostatin M receptor -0.0745294
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0741461
ASPH aspartate beta-hydroxylase -0.074077
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.072141
TNNC1 troponin C type 1 (slow) -0.0692017
COL5A1 collagen, type V, alpha 1 -0.0652286
NDRG1 N-myc downstream regulated 1 -0.0651562
FNDC3B fibronectin type III domain containing 3B -0.0601306
NAV3 neuron navigator 3 -0.0551877
ACTN4 actinin, alpha 4 -0.0509023
LOX lysyl oxidase -0.050782
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0507155
TNS3 tensin 3 -0.049817
MSN moesin -0.0496986
CADM1 cell adhesion molecule 1 -0.0485234
ANKRD11 ankyrin repeat domain 11 -0.0477804
SPAG9 sperm associated antigen 9 -0.0472364
CALD1 caldesmon 1 -0.0471444
NAMPT nicotinamide phosphoribosyltransferase -0.0464288
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0463241
SMAD3 SMAD family member 3 -0.0439955
PGK1 phosphoglycerate kinase 1 -0.0437555
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0436729
EGR1 early growth response 1 -0.0435843
GLIS3 GLIS family zinc finger 3 -0.0435678
BIRC6 baculoviral IAP repeat containing 6 -0.0434887
VEGFA vascular endothelial growth factor A -0.042359
CENPF centromere protein F, 350/400kDa -0.0421838
ATP13A3 ATPase type 13A3 -0.0413974
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0409564
FAM20C family with sequence similarity 20, member C -0.040536
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0402111
ZFAND3 zinc finger, AN1-type domain 3 -0.0400453
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0399071
MAP4 microtubule-associated protein 4 -0.0398157
LMAN1 lectin, mannose-binding, 1 -0.0395673
HIPK2 homeodomain interacting protein kinase 2 -0.039181
LDHA lactate dehydrogenase A -0.0389194
PKM pyruvate kinase, muscle -0.0388042
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0387033
ANKRD17 ankyrin repeat domain 17 -0.0381994
TXNRD1 thioredoxin reductase 1 -0.037665
MON2 MON2 homolog (S. cerevisiae) -0.0372206
RRBP1 ribosome binding protein 1 -0.0366194
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0360944
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0360029
NAV1 neuron navigator 1 -0.0355136
COPB1 coatomer protein complex, subunit beta 1 -0.0354969
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0354745
LOXL2 lysyl oxidase-like 2 -0.0353989
KMT2C lysine (K)-specific methyltransferase 2C -0.0348555
SEC24D SEC24 family member D -0.0345767
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0344754
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0343095
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0342701
POTEF POTE ankyrin domain family, member F -0.0341984
DGKD diacylglycerol kinase, delta 130kDa -0.0341958
ANXA2 annexin A2 -0.0338672
SON SON DNA binding protein -0.0336728
RNF216 ring finger protein 216 -0.0336286
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0335727
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0333478
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0329714
SMC5 structural maintenance of chromosomes 5 -0.0329682
COG5 component of oligomeric golgi complex 5 -0.0328681
ANTXR2 anthrax toxin receptor 2 -0.0327633
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0327242
GNAS GNAS complex locus -0.0325352
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0325155
TPI1 triosephosphate isomerase 1 -0.0324632
CDC27 cell division cycle 27 -0.0322599
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0322391
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0321202
STK17A serine/threonine kinase 17a -0.0316563
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0312662
SETD5 SET domain containing 5 -0.0311722
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0309494
SCFD2 sec1 family domain containing 2 -0.0302255
ANKRD28 ankyrin repeat domain 28 -0.0301692
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0300944
SAMD4A sterile alpha motif domain containing 4A -0.0299421
PTPRG protein tyrosine phosphatase, receptor type, G -0.0297902
USP47 ubiquitin specific peptidase 47 -0.0297745