9-ING-41_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 9-ING-41 perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 9-ING-41_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.189336
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.186284
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.109207
TPT1 tumor protein, translationally-controlled 1 0.0736061
RPS6 ribosomal protein S6 0.0633528
ZSWIM6 zinc finger, SWIM-type containing 6 0.0619183
MT2A metallothionein 2A 0.0580093
RPS8 ribosomal protein S8 0.0575509
EEF2 eukaryotic translation elongation factor 2 0.0575387
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0537153
INTS6 integrator complex subunit 6 0.0525611
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0490453
RPS12 ribosomal protein S12 0.046347
RACK1 receptor for activated C kinase 1 0.0395435
WWOX WW domain containing oxidoreductase 0.039449
CEMIP2 cell migration inducing hyaluronidase 2 0.0388863
APLP2 amyloid beta (A4) precursor-like protein 2 0.0386933
LOC102724023 ES1 protein homolog, mitochondrial 0.037805
POTEF POTE ankyrin domain family, member F 0.0370336
ENO1 enolase 1, (alpha) 0.0366161
MACROD2 MACRO domain containing 2 0.0365653
RPS2 ribosomal protein S2 0.0364151
RPS3 ribosomal protein S3 0.034205
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0340941
LRRC23 leucine rich repeat containing 23 0.0336197
ACTG1 actin gamma 1 0.0325368
SET SET nuclear proto-oncogene 0.0325205
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0313497
HOMER1 homer scaffolding protein 1 0.0300229
RPL26 ribosomal protein L26 0.0294963
RPS17 ribosomal protein S17 0.0293787
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0290907
RPL7 ribosomal protein L7 0.0287096
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0285015
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0276009
RPL37A ribosomal protein L37a 0.0275891
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0273077
SGMS2 sphingomyelin synthase 2 0.0266604
EIF1 eukaryotic translation initiation factor 1 0.0260083
ANXA2 annexin A2 0.0259805
TPI1 triosephosphate isomerase 1 0.0258021
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0253267
VCL vinculin 0.0252983
RPL36 ribosomal protein L36 0.0251539
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0249292
RPL12 ribosomal protein L12 0.0240284
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.0236675
B2M beta-2-microglobulin 0.0232301
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0230804
PARD3B par-3 family cell polarity regulator beta 0.02306
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0226353
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.022449
S100A10 S100 calcium binding protein A10 0.0220341
RPL4 ribosomal protein L4 0.0212469
RPL8 ribosomal protein L8 0.0210288
EPB41L5 erythrocyte membrane protein band 4.1 like 5 0.0208057
RPL32 ribosomal protein L32 0.0204487
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0203478
FAF1 Fas (TNFRSF6) associated factor 1 0.0202177
IPO7 importin 7 0.0201461
CLU clusterin 0.0201093
RPL23 ribosomal protein L23 0.019806
RPLP0 ribosomal protein, large, P0 0.0197792
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0193569
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0193463
HMGA1 high mobility group AT-hook 1 0.0191448
FHIT fragile histidine triad 0.0189513
RPS27 ribosomal protein S27 0.0188099
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0187187
AKAP12 A kinase (PRKA) anchor protein 12 0.0186548
RPL18 ribosomal protein L18 0.0185315
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0184901
SKP1 S-phase kinase-associated protein 1 0.0184735
RPL19 ribosomal protein L19 0.0184372
EFNB2 ephrin-B2 0.0183751
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0183163
PCDH7 protocadherin 7 0.0181851
PDIA4 protein disulfide isomerase family A, member 4 0.0181733
EIF4A3 eukaryotic translation initiation factor 4A3 0.0178198
EIF4A2 eukaryotic translation initiation factor 4A2 0.0178097
GPHN gephyrin 0.0178051
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 0.0177869
GLS2 glutaminase 2 (liver, mitochondrial) 0.0177106
KIF5B kinesin family member 5B 0.0176459
CHRM3 cholinergic receptor, muscarinic 3 0.0176087
RPL9 ribosomal protein L9 0.0174736
RPS11 ribosomal protein S11 0.0171349
RPL31 ribosomal protein L31 0.0170758
IFITM3 interferon induced transmembrane protein 3 0.017048
TJP1 tight junction protein 1 0.016964
PA2G4 proliferation-associated 2G4, 38kDa 0.0168998
RPL35 ribosomal protein L35 0.0168047
KDM3B lysine (K)-specific demethylase 3B 0.0166088
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.016489
HLA-B major histocompatibility complex, class I, B 0.0164705
ITGA6 integrin, alpha 6 0.0163623
PPP1R13B protein phosphatase 1, regulatory subunit 13B 0.0163273
UBC ubiquitin C 0.0162537
CTSB cathepsin B 0.0161455
RPL37 ribosomal protein L37 0.0161226

decreased expression

Symbol Name Standardized Value
P4HB prolyl 4-hydroxylase, beta polypeptide -0.16938
FAT1 FAT atypical cadherin 1 -0.165931
PTMA prothymosin, alpha -0.165641
NDRG1 N-myc downstream regulated 1 -0.151862
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0922155
TBC1D22A TBC1 domain family, member 22A -0.0908803
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0901544
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0823711
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0788945
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0786744
DSCAM Down syndrome cell adhesion molecule -0.0774606
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0669647
SETD5 SET domain containing 5 -0.0658955
RAD51B RAD51 paralog B -0.0624629
GOLGA4 golgin A4 -0.0622095
DLG1 discs, large homolog 1 (Drosophila) -0.0622058
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0583878
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0582102
ARF4 ADP-ribosylation factor 4 -0.0581081
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0558334
ANKRD11 ankyrin repeat domain 11 -0.053312
TPM4 tropomyosin 4 -0.0521263
FDPS farnesyl diphosphate synthase -0.0520722
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0520246
MON2 MON2 homolog (S. cerevisiae) -0.0516155
NF1 neurofibromin 1 -0.0513162
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0503963
BIRC6 baculoviral IAP repeat containing 6 -0.050375
SRRM2 serine/arginine repetitive matrix 2 -0.0503419
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0498335
MYH9 myosin, heavy chain 9, non-muscle -0.0479995
MBD5 methyl-CpG binding domain protein 5 -0.0478042
SRP54 signal recognition particle 54kDa -0.0454265
LCORL ligand dependent nuclear receptor corepressor-like -0.0445021
ZNF638 zinc finger protein 638 -0.0444547
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0442048
HOOK2 hook microtubule-tethering protein 2 -0.0430237
COPB1 coatomer protein complex, subunit beta 1 -0.0427691
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0416372
SUCO SUN domain containing ossification factor -0.0410976
AKAP9 A kinase (PRKA) anchor protein 9 -0.0408054
PGK1 phosphoglycerate kinase 1 -0.0405227
PRELID2 PRELI domain containing 2 -0.0403642
FLNB filamin B, beta -0.0401987
NPEPPS aminopeptidase puromycin sensitive -0.039952
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0398797
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0397496
CTBP2 C-terminal binding protein 2 -0.0396078
CD2AP CD2-associated protein -0.039406
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0393254
SCARB1 scavenger receptor class B, member 1 -0.0392794
CANX calnexin -0.0378764
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0377646
JMJD1C jumonji domain containing 1C -0.0375646
WSB1 WD repeat and SOCS box containing 1 -0.0375644
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0375591
WASF2 WAS protein family, member 2 -0.0374315
TMEM41B transmembrane protein 41B -0.0374303
INSIG2 insulin induced gene 2 -0.0368976
KDM4C lysine (K)-specific demethylase 4C -0.0359201
TTC3 tetratricopeptide repeat domain 3 -0.0358989
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0358974
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0358342
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0357724
STRN3 striatin, calmodulin binding protein 3 -0.0357169
RAD21 RAD21 homolog (S. pombe) -0.0355018
COPA coatomer protein complex, subunit alpha -0.0354212
PKM pyruvate kinase, muscle -0.0353837
GOLGA2 golgin A2 -0.0351647
MYOF myoferlin -0.0350383
PTK2 protein tyrosine kinase 2 -0.034915
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0348193
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0348054
SEC31A SEC31 homolog A (S. cerevisiae) -0.034529
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0343383
ACBD3 acyl-CoA binding domain containing 3 -0.0342929
PATJ PATJ crumbs cell polarity complex component -0.0342125
HDLBP high density lipoprotein binding protein -0.0341385
ZNF292 zinc finger protein 292 -0.0339821
HMBOX1 homeobox containing 1 -0.0337048
PNISR PNN-interacting serine/arginine-rich protein -0.0333116
IARS1 isoleucyl-tRNA synthetase 1 -0.0331078
PCBP2 poly(rC) binding protein 2 -0.0331024
FTH1 ferritin, heavy polypeptide 1 -0.0320295
MORF4L2 mortality factor 4 like 2 -0.031801
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0317216
LCOR ligand dependent nuclear receptor corepressor -0.0317202
GLG1 golgi glycoprotein 1 -0.0316052
ATM ATM serine/threonine kinase -0.0314124
KMT2E lysine (K)-specific methyltransferase 2E -0.0313995
CDK19 cyclin-dependent kinase 19 -0.0313014
MSI2 musashi RNA-binding protein 2 -0.0311864
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0305883
BRWD3 bromodomain and WD repeat domain containing 3 -0.0302487
ESYT2 extended synaptotagmin-like protein 2 -0.030197
KMT2C lysine (K)-specific methyltransferase 2C -0.0300517
KDM3A lysine (K)-specific demethylase 3A -0.0300298
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0299695
SOS1 son of sevenless homolog 1 (Drosophila) -0.0298434
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.029823