9-ING-41_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 9-ING-41 perturbation in HEC-1-A cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the 9-ING-41_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.150679
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.11885
TPT1 tumor protein, translationally-controlled 1 0.117146
ZBTB20 zinc finger and BTB domain containing 20 0.106043
MKI67 marker of proliferation Ki-67 0.094139
ALCAM activated leukocyte cell adhesion molecule 0.0847482
ACTG1 actin gamma 1 0.0797791
EEF2 eukaryotic translation elongation factor 2 0.0785265
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0721046
MACROD2 MACRO domain containing 2 0.0659455
PATJ PATJ crumbs cell polarity complex component 0.0626174
SQSTM1 sequestosome 1 0.0604255
RPS8 ribosomal protein S8 0.059956
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0574555
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0570917
EIF1 eukaryotic translation initiation factor 1 0.0550144
VCL vinculin 0.0523397
WWOX WW domain containing oxidoreductase 0.0502174
RPS2 ribosomal protein S2 0.0498666
BPTF bromodomain PHD finger transcription factor 0.0467548
SVIL supervillin 0.0459876
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0449845
RPL35A ribosomal protein L35a 0.0440298
BBS9 Bardet-Biedl syndrome 9 0.0436145
ATXN1 ataxin 1 0.0434933
RPS12 ribosomal protein S12 0.0428198
RAD51B RAD51 paralog B 0.0423077
RPL31 ribosomal protein L31 0.0414605
RPS27A ribosomal protein S27a 0.0413562
PCLO piccolo presynaptic cytomatrix protein 0.0395442
RPS6 ribosomal protein S6 0.0394723
RPL12 ribosomal protein L12 0.039463
ASPH aspartate beta-hydroxylase 0.0391662
RHEX regulator of hemoglobinization and erythroid cell expansion 0.038732
RACK1 receptor for activated C kinase 1 0.0383789
MACC1 metastasis associated in colon cancer 1 0.0376534
RFC3 replication factor C (activator 1) 3, 38kDa 0.0375659
RPS3 ribosomal protein S3 0.0359766
LPP LIM domain containing preferred translocation partner in lipoma 0.0359133
TUBB4B tubulin, beta 4B class IVb 0.0357723
ITGB6 integrin, beta 6 0.0355613
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0353495
THSD7A thrombospondin, type I, domain containing 7A 0.0349364
MBD5 methyl-CpG binding domain protein 5 0.0348758
FHIT fragile histidine triad 0.0337792
AEBP2 AE binding protein 2 0.0337393
RPL9 ribosomal protein L9 0.0336685
RPL37A ribosomal protein L37a 0.0335413
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0332288
CSNK1A1 casein kinase 1, alpha 1 0.0331143
SET SET nuclear proto-oncogene 0.0330855
OXR1 oxidation resistance 1 0.0330442
LAMB3 laminin, beta 3 0.0328493
RPL7A ribosomal protein L7a 0.0324798
RPS25 ribosomal protein S25 0.0323981
RPL26 ribosomal protein L26 0.0322968
SUMF1 sulfatase modifying factor 1 0.0320621
ERBIN erbb2 interacting protein 0.0315216
GOLGB1 golgin B1 0.0314677
SSH2 slingshot protein phosphatase 2 0.0314565
BCAS3 breast carcinoma amplified sequence 3 0.0312352
BRCA1 breast cancer 1, early onset 0.0310699
TNRC6B trinucleotide repeat containing 6B 0.0306484
N4BP2L2 NEDD4 binding protein 2-like 2 0.0305674
ENO1 enolase 1, (alpha) 0.0304659
PTPRK protein tyrosine phosphatase, receptor type, K 0.0303769
SCAPER S-phase cyclin A-associated protein in the ER 0.029865
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0297076
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0296686
SKAP2 src kinase associated phosphoprotein 2 0.0294575
AHNAK AHNAK nucleoprotein 0.0291392
CCDC138 coiled-coil domain containing 138 0.0290498
RPL11 ribosomal protein L11 0.0284662
CDK13 cyclin-dependent kinase 13 0.028362
RPL7 ribosomal protein L7 0.0282559
PTMA prothymosin, alpha 0.0281584
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0280153
ZRANB3 zinc finger, RAN-binding domain containing 3 0.0279533
RPS29 ribosomal protein S29 0.0279312
PARD3B par-3 family cell polarity regulator beta 0.0278554
PHF3 PHD finger protein 3 0.0277167
ITGAV integrin, alpha V 0.0275254
RPL37 ribosomal protein L37 0.0273158
DSPP dentin sialophosphoprotein 0.0271782
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0269977
MYO9A myosin IXA 0.0267239
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0266171
RPL23 ribosomal protein L23 0.0265722
NRIP1 nuclear receptor interacting protein 1 0.0264196
RPS17 ribosomal protein S17 0.0262941
FBXL20 F-box and leucine-rich repeat protein 20 0.0260021
RANBP17 RAN binding protein 17 0.0258358
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0258347
CFAP44 cilia and flagella associated protein 44 0.0257738
TUSC3 tumor suppressor candidate 3 0.0257517
ANKRD10 ankyrin repeat domain 10 0.0256392
EXT1 exostosin glycosyltransferase 1 0.0254443
ZSWIM6 zinc finger, SWIM-type containing 6 0.0254375
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0253143
RPLP0 ribosomal protein, large, P0 0.0249349

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.140468
IGFBP3 insulin-like growth factor binding protein 3 -0.107647
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0875009
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0819479
TMSB10 thymosin beta 10 -0.0809076
RNF145 ring finger protein 145 -0.0598463
PAX8 paired box 8 -0.0596697
FLNB filamin B, beta -0.0593626
POTEF POTE ankyrin domain family, member F -0.058557
HELZ helicase with zinc finger -0.0578531
HMGA1 high mobility group AT-hook 1 -0.0552086
FNDC3B fibronectin type III domain containing 3B -0.0537581
MT2A metallothionein 2A -0.0513085
FTH1 ferritin, heavy polypeptide 1 -0.0498585
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0498261
LIMCH1 LIM and calponin homology domains 1 -0.0484462
P4HB prolyl 4-hydroxylase, beta polypeptide -0.047761
FNBP1L formin binding protein 1-like -0.0454653
TSC22D2 TSC22 domain family, member 2 -0.0454106
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0443909
ZNF292 zinc finger protein 292 -0.0430347
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0424946
FOSL1 FOS-like antigen 1 -0.0418656
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 -0.0414211
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0408274
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0407928
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.040726
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.039157
KRT7 keratin 7, type II -0.0388764
ANXA2 annexin A2 -0.0365813
NUP58 nucleoporin 58 -0.0363871
PCBP2 poly(rC) binding protein 2 -0.0362502
IRS2 insulin receptor substrate 2 -0.0358924
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0356457
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0354128
INSIG2 insulin induced gene 2 -0.0347439
RUNX1 runt-related transcription factor 1 -0.0344825
PFN1 profilin 1 -0.034298
YBX1 Y box binding protein 1 -0.03418
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0340985
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0336458
UGCG UDP-glucose ceramide glucosyltransferase -0.0335849
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0329667
SBF2 SET binding factor 2 -0.032553
ADAM9 ADAM metallopeptidase domain 9 -0.0308804
VEGFA vascular endothelial growth factor A -0.0302947
TRIO trio Rho guanine nucleotide exchange factor -0.0302629
GOLGA4 golgin A4 -0.0301003
EGFR epidermal growth factor receptor -0.029956
TFG TRK-fused gene -0.0297569
MATR3 matrin 3 -0.0295805
GARS1 glycyl-tRNA synthetase 1 -0.0294921
SREBF2 sterol regulatory element binding transcription factor 2 -0.029252
FBXL2 F-box and leucine-rich repeat protein 2 -0.0291205
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0283559
NPEPPS aminopeptidase puromycin sensitive -0.0282284
HILPDA hypoxia inducible lipid droplet-associated -0.0275325
RNMT RNA (guanine-7-) methyltransferase -0.0273731
LAMA5 laminin, alpha 5 -0.0272523
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.026944
KMT2C lysine (K)-specific methyltransferase 2C -0.0268345
IARS1 isoleucyl-tRNA synthetase 1 -0.0264634
PTBP2 polypyrimidine tract binding protein 2 -0.0263718
ESYT2 extended synaptotagmin-like protein 2 -0.0260893
SRRM2 serine/arginine repetitive matrix 2 -0.026067
HSPG2 heparan sulfate proteoglycan 2 -0.0260663
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0258963
EWSR1 EWS RNA-binding protein 1 -0.0257792
SETD5 SET domain containing 5 -0.0256688
CCNL1 cyclin L1 -0.0254558
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0253951
DLC1 DLC1 Rho GTPase activating protein -0.0249058
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.024808
COL18A1 collagen, type XVIII, alpha 1 -0.0239666
DDIT4 DNA-damage-inducible transcript 4 -0.0237861
RYBP RING1 and YY1 binding protein -0.023653
RLF rearranged L-myc fusion -0.0235961
ZFP36L1 ZFP36 ring finger protein-like 1 -0.023196
EGR1 early growth response 1 -0.0231747
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0229931
USP24 ubiquitin specific peptidase 24 -0.0229114
SEC24A SEC24 family member A -0.0229033
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0228958
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0228119
ARHGAP29 Rho GTPase activating protein 29 -0.0223746
LMAN1 lectin, mannose-binding, 1 -0.0223324
RAD23B RAD23 homolog B (S. cerevisiae) -0.0223174
PDIA3 protein disulfide isomerase family A, member 3 -0.0223111
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0221683
WDR45B WD repeat domain 45B -0.0221398
MYADM myeloid-associated differentiation marker -0.021937
AGRN agrin -0.021924
WDR43 WD repeat domain 43 -0.0217156
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0215258
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0214062
LDHA lactate dehydrogenase A -0.0212368
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0212129
PRRC2B proline-rich coiled-coil 2B -0.0209777
TRA2B transformer 2 beta homolog (Drosophila) -0.0209028
LOC112694756 uncharaterized LOC112694756 -0.0208623