9-ING-41_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 9-ING-41 perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 9-ING-41_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.162383
MT2A metallothionein 2A 0.137741
VIM vimentin 0.114192
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.110741
TGFBI transforming growth factor, beta-induced, 68kDa 0.0997479
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.0962606
ENO1 enolase 1, (alpha) 0.0933432
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0933405
EXT1 exostosin glycosyltransferase 1 0.0847583
TIMP3 TIMP metallopeptidase inhibitor 3 0.0686196
IFI6 interferon, alpha-inducible protein 6 0.0676909
EIF1 eukaryotic translation initiation factor 1 0.0613116
CD44 CD44 molecule (Indian blood group) 0.0598823
RPS8 ribosomal protein S8 0.059518
RPS6 ribosomal protein S6 0.0589967
CXCL8 chemokine (C-X-C motif) ligand 8 0.0577212
RPS12 ribosomal protein S12 0.0576286
FNDC3B fibronectin type III domain containing 3B 0.0559146
CDH13 cadherin 13 0.0545491
B2M beta-2-microglobulin 0.0533724
ACTG1 actin gamma 1 0.0510567
PSD3 pleckstrin and Sec7 domain containing 3 0.0508601
RPL37A ribosomal protein L37a 0.0492868
GOLGB1 golgin B1 0.0492093
ZBTB20 zinc finger and BTB domain containing 20 0.0482892
NDRG1 N-myc downstream regulated 1 0.0474404
RPS3 ribosomal protein S3 0.046978
IGFBP7 insulin-like growth factor binding protein 7 0.0454987
SQSTM1 sequestosome 1 0.0439091
STC1 stanniocalcin 1 0.043658
ATXN1 ataxin 1 0.0429181
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0420574
ZSWIM6 zinc finger, SWIM-type containing 6 0.0410873
MBNL1 muscleblind-like splicing regulator 1 0.0404358
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0403187
ALCAM activated leukocyte cell adhesion molecule 0.0398654
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.039516
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0391514
HDAC9 histone deacetylase 9 0.038263
HLA-B major histocompatibility complex, class I, B 0.0372005
RACK1 receptor for activated C kinase 1 0.0369906
LPP LIM domain containing preferred translocation partner in lipoma 0.0364975
NAV1 neuron navigator 1 0.0357388
LGALS1 lectin, galactoside-binding, soluble, 1 0.0342493
TPT1 tumor protein, translationally-controlled 1 0.0337303
EEF2 eukaryotic translation elongation factor 2 0.0326475
ISG15 ISG15 ubiquitin-like modifier 0.0324454
IFITM3 interferon induced transmembrane protein 3 0.0320084
RPS19 ribosomal protein S19 0.031932
RPL35A ribosomal protein L35a 0.0314843
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0305898
RPS15 ribosomal protein S15 0.0305889
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0305546
PDLIM5 PDZ and LIM domain 5 0.0305266
RPS17 ribosomal protein S17 0.0293516
RPS23 ribosomal protein S23 0.0292656
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0292464
RPL26 ribosomal protein L26 0.0291947
RPL7 ribosomal protein L7 0.0291358
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0289354
INHBA inhibin, beta A 0.0288479
SP100 SP100 nuclear antigen 0.0280152
RPL37 ribosomal protein L37 0.0278061
LIMS1 LIM and senescent cell antigen-like domains 1 0.0275163
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0268045
ASPH aspartate beta-hydroxylase 0.0267754
RPL9 ribosomal protein L9 0.0263297
SLC38A2 solute carrier family 38, member 2 0.0262366
RPL23 ribosomal protein L23 0.0260707
RPL36 ribosomal protein L36 0.0259333
VCL vinculin 0.0256932
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0251637
EGFR epidermal growth factor receptor 0.0250783
ATF4 activating transcription factor 4 0.0250002
RPLP2 ribosomal protein, large, P2 0.0248655
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0247197
CNTN5 contactin 5 0.0242873
S100A10 S100 calcium binding protein A10 0.0242742
ANKRD12 ankyrin repeat domain 12 0.0242025
RPL12 ribosomal protein L12 0.0241211
IL6 interleukin 6 0.0236314
RPL18 ribosomal protein L18 0.0231107
CSNK1A1 casein kinase 1, alpha 1 0.0229975
RPS11 ribosomal protein S11 0.0228378
RPS2 ribosomal protein S2 0.022723
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0225827
RND3 Rho family GTPase 3 0.022545
RPS13 ribosomal protein S13 0.0224955
CALD1 caldesmon 1 0.0221718
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0220476
RPL8 ribosomal protein L8 0.0218904
NFE2L1 nuclear factor, erythroid 2-like 1 0.0215723
RPL11 ribosomal protein L11 0.0210829
DST dystonin 0.0209575
RPS25 ribosomal protein S25 0.0208467
SON SON DNA binding protein 0.0207124
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0204488
ANKRD28 ankyrin repeat domain 28 0.020162
LDHA lactate dehydrogenase A 0.0200322
IFITM1 interferon induced transmembrane protein 1 0.0197296

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.369842
COL6A3 collagen, type VI, alpha 3 -0.128483
FN1 fibronectin 1 -0.102063
COL1A1 collagen, type I, alpha 1 -0.0939303
ATP13A3 ATPase type 13A3 -0.0852333
IGFBP3 insulin-like growth factor binding protein 3 -0.0837704
COL1A2 collagen, type I, alpha 2 -0.0626694
TRIO trio Rho guanine nucleotide exchange factor -0.0565142
NAMPT nicotinamide phosphoribosyltransferase -0.0553622
PTMA prothymosin, alpha -0.0540413
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0540379
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0519234
ZNF292 zinc finger protein 292 -0.0485114
USP3 ubiquitin specific peptidase 3 -0.0484161
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0430279
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.040324
LOX lysyl oxidase -0.0395996
ICAM1 intercellular adhesion molecule 1 -0.0379483
SPAG9 sperm associated antigen 9 -0.0377969
QKI QKI, KH domain containing, RNA binding -0.0353176
ELL2 elongation factor, RNA polymerase II, 2 -0.0344305
WSB1 WD repeat and SOCS box containing 1 -0.0342341
RLF rearranged L-myc fusion -0.0336071
LOXL2 lysyl oxidase-like 2 -0.0320178
LMAN1 lectin, mannose-binding, 1 -0.0319495
MYH9 myosin, heavy chain 9, non-muscle -0.0315791
TM4SF1 transmembrane 4 L six family member 1 -0.0315673
MT1X metallothionein 1X -0.0313507
CADM1 cell adhesion molecule 1 -0.0307132
CANX calnexin -0.0303638
RAD21 RAD21 homolog (S. pombe) -0.0302994
CALR calreticulin -0.029163
BHLHE40 basic helix-loop-helix family, member e40 -0.0289652
KDM3A lysine (K)-specific demethylase 3A -0.0285208
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.028061
ZFAND3 zinc finger, AN1-type domain 3 -0.0274223
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0273304
TFG TRK-fused gene -0.0271552
CAMTA1 calmodulin binding transcription activator 1 -0.0267669
ANXA2 annexin A2 -0.0267565
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0265909
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0261141
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0254635
CAVIN1 caveolae associated protein 1 -0.0248361
MARCHF6 membrane associated ring-CH-type finger 6 -0.0246913
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0243278
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0241511
RBM39 RNA binding motif protein 39 -0.024029
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0239744
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0236092
FTH1 ferritin, heavy polypeptide 1 -0.0235269
TSC22D2 TSC22 domain family, member 2 -0.0234937
COL7A1 collagen, type VII, alpha 1 -0.023122
SQLE squalene epoxidase -0.0231094
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0227204
PRRC1 proline-rich coiled-coil 1 -0.0225765
YBX1 Y box binding protein 1 -0.0221783
HMGA2 high mobility group AT-hook 2 -0.0220952
BZW1 basic leucine zipper and W2 domains 1 -0.0214335
PDE10A phosphodiesterase 10A -0.0214319
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0213403
HOOK2 hook microtubule-tethering protein 2 -0.0211983
GOLGA4 golgin A4 -0.021001
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0208877
MATR3 matrin 3 -0.0208531
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0207802
COL4A1 collagen, type IV, alpha 1 -0.0206136
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -0.0202235
NPEPPS aminopeptidase puromycin sensitive -0.0202119
OGA O-GlcNAcase -0.0201763
KMT2E lysine (K)-specific methyltransferase 2E -0.0199797
ANKRD11 ankyrin repeat domain 11 -0.0199016
PXDN peroxidasin -0.0198002
POSTN periostin, osteoblast specific factor -0.0196757
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.01956
TNIP1 TNFAIP3 interacting protein 1 -0.0195325
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.0192349
RASA2 RAS p21 protein activator 2 -0.0192281
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0191053
TRAM2 translocation associated membrane protein 2 -0.019039
RHEB Ras homolog enriched in brain -0.0189349
COL4A2 collagen, type IV, alpha 2 -0.0186417
SETD5 SET domain containing 5 -0.0183155
NDFIP1 Nedd4 family interacting protein 1 -0.0181536
PDE8A phosphodiesterase 8A -0.0180424
HILPDA hypoxia inducible lipid droplet-associated -0.0177601
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0177596
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0175686
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0175079
FOXJ3 forkhead box J3 -0.0173765
WDR45B WD repeat domain 45B -0.0173667
RRBP1 ribosome binding protein 1 -0.0169254
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0168124
ADAM9 ADAM metallopeptidase domain 9 -0.0166353
CLINT1 clathrin interactor 1 -0.016607
TPM4 tropomyosin 4 -0.0165087
AZIN1 antizyme inhibitor 1 -0.0164734
HELZ helicase with zinc finger -0.0164417
IER3IP1 immediate early response 3 interacting protein 1 -0.016404
SKIC3 SKI3 subunit of superkiller complex -0.0161634