9-ING-41_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 9-ING-41 perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 9-ING-41_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS6 ribosomal protein S6 0.0900287
MT2A metallothionein 2A 0.0737154
MYOF myoferlin 0.0705836
MBNL1 muscleblind-like splicing regulator 1 0.0699705
ARHGAP29 Rho GTPase activating protein 29 0.0689213
RPS3 ribosomal protein S3 0.0615043
RPS2 ribosomal protein S2 0.0559579
EEF2 eukaryotic translation elongation factor 2 0.0510011
SQSTM1 sequestosome 1 0.0499474
CLU clusterin 0.0487418
RPS12 ribosomal protein S12 0.0471237
AOPEP aminopeptidase O (putative) 0.0458081
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0456956
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0456623
TXNIP thioredoxin interacting protein 0.0456137
CDKN2A cyclin-dependent kinase inhibitor 2A 0.045549
MBNL2 muscleblind-like splicing regulator 2 0.0453085
MSN moesin 0.0425761
DST dystonin 0.0415805
IFITM1 interferon induced transmembrane protein 1 0.0400866
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0392356
RPS19 ribosomal protein S19 0.0372228
IGF2 insulin-like growth factor 2 0.036462
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0363752
SET SET nuclear proto-oncogene 0.0360162
ENO1 enolase 1, (alpha) 0.034939
KTN1 kinectin 1 (kinesin receptor) 0.0333695
ERBIN erbb2 interacting protein 0.0326466
DOK5 docking protein 5 0.0324939
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0323114
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0323097
FOXP1 forkhead box P1 0.032186
KLF5 Kruppel-like factor 5 (intestinal) 0.0319832
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.0311676
FN1 fibronectin 1 0.0309282
FNDC3B fibronectin type III domain containing 3B 0.0304155
RPL8 ribosomal protein L8 0.030367
RPS23 ribosomal protein S23 0.0298656
MACF1 microtubule-actin crosslinking factor 1 0.0298435
NEK7 NIMA-related kinase 7 0.029549
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0293462
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0291157
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0284568
LIFR leukemia inhibitory factor receptor alpha 0.0284537
ANKRD12 ankyrin repeat domain 12 0.0284532
SYNE2 spectrin repeat containing, nuclear envelope 2 0.028286
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0281707
RPL7 ribosomal protein L7 0.0281158
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) 0.0270728
RICTOR RPTOR independent companion of MTOR, complex 2 0.0264949
RPL37A ribosomal protein L37a 0.0264565
PCBP2 poly(rC) binding protein 2 0.0264563
RPLP2 ribosomal protein, large, P2 0.0264505
YBX3 Y box binding protein 3 0.0262947
DSCAM Down syndrome cell adhesion molecule 0.0261908
RPL37 ribosomal protein L37 0.0253337
CEMIP cell migration inducing protein, hyaluronan binding 0.0253093
RPS8 ribosomal protein S8 0.0250509
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0246133
PLPP6 phospholipid phosphatase 6 0.0245706
TNRC6B trinucleotide repeat containing 6B 0.0245449
GBP2 guanylate binding protein 2, interferon-inducible 0.0244802
IFITM3 interferon induced transmembrane protein 3 0.0242
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0239566
SLC38A2 solute carrier family 38, member 2 0.023855
KMT2E lysine (K)-specific methyltransferase 2E 0.0237989
TJP1 tight junction protein 1 0.0237267
UBE2H ubiquitin-conjugating enzyme E2H 0.0237211
ANKRD28 ankyrin repeat domain 28 0.0236468
RPL11 ribosomal protein L11 0.023571
OSBPL6 oxysterol binding protein-like 6 0.0231712
IL6ST interleukin 6 signal transducer 0.0229112
RACK1 receptor for activated C kinase 1 0.0225211
CENPF centromere protein F, 350/400kDa 0.022469
RPS17 ribosomal protein S17 0.0221031
EIF1 eukaryotic translation initiation factor 1 0.0220851
PCM1 pericentriolar material 1 0.0219272
TPR translocated promoter region, nuclear basket protein 0.0217542
KLHL24 kelch-like family member 24 0.0216396
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0215092
EPS8 epidermal growth factor receptor pathway substrate 8 0.0214452
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0212957
RB1CC1 RB1-inducible coiled-coil 1 0.0210885
CDK17 cyclin-dependent kinase 17 0.0209049
NT5C2 5'-nucleotidase, cytosolic II 0.0208438
IRS2 insulin receptor substrate 2 0.0205739
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.0204464
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 0.0204124
RPL36 ribosomal protein L36 0.0203795
DYNLRB1 dynein, light chain, roadblock-type 1 0.0202747
TRIP12 thyroid hormone receptor interactor 12 0.0201863
RPL19 ribosomal protein L19 0.0200021
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0199671
TPX2 TPX2, microtubule-associated 0.0198873
PUM2 pumilio RNA-binding family member 2 0.0198578
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.01982
MKI67 marker of proliferation Ki-67 0.0197178
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0197128
ECE1 endothelin converting enzyme 1 0.0196691
ARRDC3 arrestin domain containing 3 0.0195216

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.233477
MTSS1 metastasis suppressor 1 -0.229955
TIMP3 TIMP metallopeptidase inhibitor 3 -0.210572
FLNB filamin B, beta -0.192085
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.19008
SLC35F3 solute carrier family 35, member F3 -0.149241
PTMA prothymosin, alpha -0.107269
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0993222
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.090042
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0869731
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0862099
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.083769
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0730526
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0724585
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0714102
RCOR1 REST corepressor 1 -0.0691351
NDRG1 N-myc downstream regulated 1 -0.0685252
PALLD palladin, cytoskeletal associated protein -0.0678171
BLCAP bladder cancer associated protein -0.0646996
ANXA2 annexin A2 -0.0642828
PSD3 pleckstrin and Sec7 domain containing 3 -0.0627661
TMSB10 thymosin beta 10 -0.0606826
LAMC2 laminin, gamma 2 -0.0601859
ANO1 anoctamin 1, calcium activated chloride channel -0.05814
INTS6 integrator complex subunit 6 -0.0580314
SQLE squalene epoxidase -0.0579942
MEF2A myocyte enhancer factor 2A -0.057536
EMP1 epithelial membrane protein 1 -0.056679
EXT1 exostosin glycosyltransferase 1 -0.0561854
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0554253
PODXL podocalyxin-like -0.0552964
STC1 stanniocalcin 1 -0.05481
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0533987
S100A10 S100 calcium binding protein A10 -0.0531696
HM13 histocompatibility (minor) 13 -0.0530694
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0525891
ALCAM activated leukocyte cell adhesion molecule -0.0504452
TMSB4X thymosin beta 4, X-linked -0.0503976
GRB10 growth factor receptor-bound protein 10 -0.0498947
SULF2 sulfatase 2 -0.0484649
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0457662
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0456313
PTK2 protein tyrosine kinase 2 -0.0439668
CALU calumenin -0.0430775
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0426214
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0424994
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0420914
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0418029
HSPG2 heparan sulfate proteoglycan 2 -0.0417797
PGK1 phosphoglycerate kinase 1 -0.0409819
ABI3BP ABI family, member 3 (NESH) binding protein -0.0409186
LMNA lamin A/C -0.0406911
LDLR low density lipoprotein receptor -0.03927
CDC42 cell division cycle 42 -0.0390757
OXR1 oxidation resistance 1 -0.0389936
HLA-B major histocompatibility complex, class I, B -0.0387633
BCAR3 breast cancer anti-estrogen resistance 3 -0.0384115
ZEB1 zinc finger E-box binding homeobox 1 -0.038269
LDHA lactate dehydrogenase A -0.0371293
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0368279
RPS24 ribosomal protein S24 -0.0359209
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -0.0351656
LOC112694756 uncharaterized LOC112694756 -0.0348636
RRBP1 ribosome binding protein 1 -0.0346898
COL4A5 collagen, type IV, alpha 5 -0.0346733
NUMB numb homolog (Drosophila) -0.0344434
F3 coagulation factor III (thromboplastin, tissue factor) -0.0343305
H1-0 H1.0 linker histone -0.0341697
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0341128
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0339397
NRIP1 nuclear receptor interacting protein 1 -0.0337478
PPARG peroxisome proliferator-activated receptor gamma -0.0336635
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.033458
THBD thrombomodulin -0.0332636
WARS1 tryptophanyl-tRNA synthetase 1 -0.0323054
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0319963
EGR1 early growth response 1 -0.0319232
PLEC plectin -0.0317054
NCOR2 nuclear receptor corepressor 2 -0.0307173
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0306926
MPRIP myosin phosphatase Rho interacting protein -0.0304777
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0303852
AFAP1 actin filament associated protein 1 -0.0303739
CAVIN1 caveolae associated protein 1 -0.0299045
ZFAND3 zinc finger, AN1-type domain 3 -0.0298769
CSNK1E casein kinase 1, epsilon -0.0298714
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0298684
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0296571
TPM4 tropomyosin 4 -0.0294984
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0292929
TSC22D1 TSC22 domain family, member 1 -0.0291125
CLIC4 chloride intracellular channel 4 -0.0290006
FSCN1 fascin actin-bundling protein 1 -0.0288395
PYGL phosphorylase, glycogen, liver -0.0288231
BLZF1 basic leucine zipper nuclear factor 1 -0.0287247
CALR calreticulin -0.0286639
CSMD2 CUB and Sushi multiple domains 2 -0.0285676
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0284973
TMEM263 transmembrane protein 263 -0.0282925
WDFY2 WD repeat and FYVE domain containing 2 -0.0280896