9-ING-41_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 9-ING-41 perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 9-ING-41_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.317147
MT2A metallothionein 2A 0.289992
B2M beta-2-microglobulin 0.107065
ENO1 enolase 1, (alpha) 0.105949
RPS6 ribosomal protein S6 0.102927
RPS3 ribosomal protein S3 0.101212
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0874529
LDHA lactate dehydrogenase A 0.087078
NDRG1 N-myc downstream regulated 1 0.0834746
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0833178
FTL ferritin, light polypeptide 0.0815762
RPS12 ribosomal protein S12 0.0760255
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0757075
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0674532
RPS8 ribosomal protein S8 0.0674046
ACTG1 actin gamma 1 0.0609475
RPL37A ribosomal protein L37a 0.0600552
VIM vimentin 0.059915
SET SET nuclear proto-oncogene 0.0582385
HLA-B major histocompatibility complex, class I, B 0.0566786
EIF1 eukaryotic translation initiation factor 1 0.0564136
TPT1 tumor protein, translationally-controlled 1 0.0553165
POTEF POTE ankyrin domain family, member F 0.0495658
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0492041
LOC102724023 ES1 protein homolog, mitochondrial 0.0472139
S100A10 S100 calcium binding protein A10 0.0465484
RPS17 ribosomal protein S17 0.0446796
RACK1 receptor for activated C kinase 1 0.0434219
IFITM3 interferon induced transmembrane protein 3 0.0432201
RPL12 ribosomal protein L12 0.0430741
RPL19 ribosomal protein L19 0.0420768
SQSTM1 sequestosome 1 0.0418176
ADM adrenomedullin 0.0375837
RPL26 ribosomal protein L26 0.0354252
DYNLRB1 dynein, light chain, roadblock-type 1 0.0342961
RPL7 ribosomal protein L7 0.0342913
RPS23 ribosomal protein S23 0.0332573
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0329361
RPL32 ribosomal protein L32 0.0326826
RPL18 ribosomal protein L18 0.0316152
RPL36 ribosomal protein L36 0.0307253
RPL8 ribosomal protein L8 0.0303162
LIMA1 LIM domain and actin binding 1 0.0300315
SLC38A2 solute carrier family 38, member 2 0.0293368
RPLP0 ribosomal protein, large, P0 0.0287475
PKM pyruvate kinase, muscle 0.0284918
ANXA1 annexin A1 0.0281825
RPL37 ribosomal protein L37 0.0278958
RPS19 ribosomal protein S19 0.0278013
PTPRF protein tyrosine phosphatase, receptor type, F 0.027763
RPS2 ribosomal protein S2 0.0272143
RPS27 ribosomal protein S27 0.0268342
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0268133
ENO2 enolase 2 (gamma, neuronal) 0.0268044
RPL10A ribosomal protein L10a 0.0264505
UBC ubiquitin C 0.0258683
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0255629
RPL35A ribosomal protein L35a 0.0255493
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0254378
PODXL podocalyxin-like 0.0254348
TLE4 transducin-like enhancer of split 4 0.0251231
VDAC1 voltage-dependent anion channel 1 0.0250015
EEF2 eukaryotic translation elongation factor 2 0.0247665
TMSB10 thymosin beta 10 0.0245501
MBNL2 muscleblind-like splicing regulator 2 0.0244912
SLIT2 slit homolog 2 (Drosophila) 0.0243703
PA2G4 proliferation-associated 2G4, 38kDa 0.0242147
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0239867
PDLIM5 PDZ and LIM domain 5 0.0237411
RPS13 ribosomal protein S13 0.0235891
TUBA1B tubulin, alpha 1b 0.0235574
RPL35 ribosomal protein L35 0.0235569
CD59 CD59 molecule, complement regulatory protein 0.0234467
KRT7 keratin 7, type II 0.023362
RPL28 ribosomal protein L28 0.023277
INTS6 integrator complex subunit 6 0.0231998
PLIN2 perilipin 2 0.0230396
RPL9 ribosomal protein L9 0.0229392
RPLP2 ribosomal protein, large, P2 0.022845
RPS15 ribosomal protein S15 0.0221324
ASTN2 astrotactin 2 0.0220374
SON SON DNA binding protein 0.0218679
FLNB filamin B, beta 0.0218569
DSTN destrin (actin depolymerizing factor) 0.0217849
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0217518
HEG1 heart development protein with EGF-like domains 1 0.0216698
RPL5 ribosomal protein L5 0.0214743
IFI6 interferon, alpha-inducible protein 6 0.0213399
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0213272
RPS27A ribosomal protein S27a 0.0211403
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0210549
RPS14 ribosomal protein S14 0.0209738
CALD1 caldesmon 1 0.0206912
RPL23 ribosomal protein L23 0.0206488
IFITM1 interferon induced transmembrane protein 1 0.0202671
ANXA2 annexin A2 0.020149
MKI67 marker of proliferation Ki-67 0.0200191
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0198621
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 0.0198379
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0198292

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.119952
NALF1 NALCN channel auxiliary factor 1 -0.118685
FN1 fibronectin 1 -0.111208
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.107177
EXT1 exostosin glycosyltransferase 1 -0.0810606
ABI3BP ABI family, member 3 (NESH) binding protein -0.0741742
MT1X metallothionein 1X -0.060376
PTMA prothymosin, alpha -0.0545442
CALR calreticulin -0.052234
PHACTR1 phosphatase and actin regulator 1 -0.0508485
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0477569
NAMPT nicotinamide phosphoribosyltransferase -0.0470829
DLG1 discs, large homolog 1 (Drosophila) -0.0451435
PTK2 protein tyrosine kinase 2 -0.0407237
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0403477
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0388594
CANX calnexin -0.0338515
PLCB4 phospholipase C, beta 4 -0.0321103
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0308895
ELL2 elongation factor, RNA polymerase II, 2 -0.030214
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.028716
ZMYND8 zinc finger, MYND-type containing 8 -0.0275337
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0273652
TMSB4X thymosin beta 4, X-linked -0.0271666
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0260394
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0259653
HLA-C major histocompatibility complex, class I, C -0.02587
F3 coagulation factor III (thromboplastin, tissue factor) -0.0257856
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0257168
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0242117
KPNB1 karyopherin (importin) beta 1 -0.0241969
DPYD dihydropyrimidine dehydrogenase -0.0237684
RLF rearranged L-myc fusion -0.0232328
CCBE1 collagen and calcium binding EGF domains 1 -0.0231285
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0230364
DIAPH3 diaphanous-related formin 3 -0.0229232
SULF1 sulfatase 1 -0.0228492
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0227206
HMGB1 high mobility group box 1 -0.0224461
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0220263
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0219256
NF1 neurofibromin 1 -0.0218885
RRBP1 ribosome binding protein 1 -0.0211201
NIPBL Nipped-B homolog (Drosophila) -0.0209191
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0208456
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0207437
STAU1 staufen double-stranded RNA binding protein 1 -0.0205316
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0204097
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.02029
ANKRD11 ankyrin repeat domain 11 -0.0201061
TMEM41B transmembrane protein 41B -0.0198828
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0198465
NPEPPS aminopeptidase puromycin sensitive -0.0197952
SAMD12 sterile alpha motif domain containing 12 -0.0196797
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0196754
ZNF804A zinc finger protein 804A -0.0196566
SMYD3 SET and MYND domain containing 3 -0.0195281
KDM2A lysine (K)-specific demethylase 2A -0.0194968
COPB1 coatomer protein complex, subunit beta 1 -0.0192488
IARS1 isoleucyl-tRNA synthetase 1 -0.0191216
FOSL1 FOS-like antigen 1 -0.0188712
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0187645
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.018705
MMP12 matrix metallopeptidase 12 -0.0185479
PRRC2B proline-rich coiled-coil 2B -0.0184404
SENP5 SUMO1/sentrin specific peptidase 5 -0.0183315
RBM6 RNA binding motif protein 6 -0.0181994
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0181552
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -0.0180186
LIMCH1 LIM and calponin homology domains 1 -0.0177947
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0177865
ENOSF1 enolase superfamily member 1 -0.0177667
TRIM56 tripartite motif containing 56 -0.0174221
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0173105
WNT5B wingless-type MMTV integration site family, member 5B -0.017215
XPO1 exportin 1 -0.0171064
GMPS guanine monphosphate synthase -0.0170467
OSMR oncostatin M receptor -0.0170405
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0168453
FAF1 Fas (TNFRSF6) associated factor 1 -0.0168179
AFAP1 actin filament associated protein 1 -0.0167841
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0166778
RAD51B RAD51 paralog B -0.0166242
FOXP1 forkhead box P1 -0.0165296
MATR3 matrin 3 -0.0165114
PDS5A PDS5 cohesin associated factor A -0.0164893
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0162255
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.016224
RPS21 ribosomal protein S21 -0.0162202
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0161864
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0161232
FAM193A family with sequence similarity 193, member A -0.01611
INVS inversin -0.0158396
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0157244
COL4A2 collagen, type IV, alpha 2 -0.0156343
ZNF432 zinc finger protein 432 -0.0156111
SDC4 syndecan 4 -0.0155827
LYPD6B LY6/PLAUR domain containing 6B -0.0154554
RAI14 retinoic acid induced 14 -0.0153702
SRPK2 SRSF protein kinase 2 -0.0153164