9-ING-41_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 9-ING-41 perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 9-ING-41_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.227614
TPT1 tumor protein, translationally-controlled 1 0.150339
RPS6 ribosomal protein S6 0.116574
RPS12 ribosomal protein S12 0.110206
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0757387
MYO1E myosin IE 0.0716351
RPS8 ribosomal protein S8 0.0676242
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0664183
FTL ferritin, light polypeptide 0.0624102
LOC102724023 ES1 protein homolog, mitochondrial 0.0623604
AREG amphiregulin 0.0562471
RPS3 ribosomal protein S3 0.056011
EIF1 eukaryotic translation initiation factor 1 0.0550178
EXT1 exostosin glycosyltransferase 1 0.0532988
RPL12 ribosomal protein L12 0.0515812
RPL26 ribosomal protein L26 0.0503196
RPL37A ribosomal protein L37a 0.0496473
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0490893
EEF2 eukaryotic translation elongation factor 2 0.0471063
RPL9 ribosomal protein L9 0.0446506
RPS29 ribosomal protein S29 0.0422089
RPL35A ribosomal protein L35a 0.040748
LURAP1L leucine rich adaptor protein 1-like 0.0397878
RPL31 ribosomal protein L31 0.0388266
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0387753
RPS19 ribosomal protein S19 0.0386518
RPL34 ribosomal protein L34 0.0377749
RPL36 ribosomal protein L36 0.0375486
RPS2 ribosomal protein S2 0.0374302
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0367459
SQSTM1 sequestosome 1 0.0367406
RPS23 ribosomal protein S23 0.0366439
RPS17 ribosomal protein S17 0.0355844
RPS25 ribosomal protein S25 0.0345485
RPS27A ribosomal protein S27a 0.0344994
SOX9 SRY (sex determining region Y)-box 9 0.0343805
RPLP2 ribosomal protein, large, P2 0.034323
MT2A metallothionein 2A 0.0320664
RPL11 ribosomal protein L11 0.0319667
FOXP1 forkhead box P1 0.0315786
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0312847
MBNL1 muscleblind-like splicing regulator 1 0.0312162
RPS27 ribosomal protein S27 0.0311674
NEBL nebulette 0.0311527
B2M beta-2-microglobulin 0.0311439
RPLP0 ribosomal protein, large, P0 0.0310127
NCOA7 nuclear receptor coactivator 7 0.0307899
AFF1 AF4/FMR2 family, member 1 0.0303032
MED13 mediator complex subunit 13 0.0298076
ZBTB20 zinc finger and BTB domain containing 20 0.0296754
RPL19 ribosomal protein L19 0.0293215
RPS13 ribosomal protein S13 0.0293119
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0292362
SLC38A2 solute carrier family 38, member 2 0.0287819
PTPRK protein tyrosine phosphatase, receptor type, K 0.0287389
RPL23 ribosomal protein L23 0.0283422
MUC13 mucin 13, cell surface associated 0.0282884
RPS5 ribosomal protein S5 0.0276758
ALCAM activated leukocyte cell adhesion molecule 0.0275834
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0275343
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0269191
RPL7 ribosomal protein L7 0.0265482
ISG15 ISG15 ubiquitin-like modifier 0.026541
FHIT fragile histidine triad 0.0264108
PDZD8 PDZ domain containing 8 0.026277
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0262513
RPL37 ribosomal protein L37 0.0261252
RPL7A ribosomal protein L7a 0.025441
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0254341
RPL18 ribosomal protein L18 0.0241051
EPS8 epidermal growth factor receptor pathway substrate 8 0.023638
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0233697
RPL28 ribosomal protein L28 0.0233441
CD44 CD44 molecule (Indian blood group) 0.0231565
RPL8 ribosomal protein L8 0.0229629
RPS10 ribosomal protein S10 0.0229613
SMAD2 SMAD family member 2 0.0227251
PABPC1 poly(A) binding protein, cytoplasmic 1 0.022562
RPS11 ribosomal protein S11 0.0216899
TGFBR3 transforming growth factor, beta receptor III 0.0216276
CCSER1 coiled-coil serine-rich protein 1 0.0215392
KLF5 Kruppel-like factor 5 (intestinal) 0.0215252
RPL10A ribosomal protein L10a 0.0215077
RPL15 ribosomal protein L15 0.0208666
EIF4A2 eukaryotic translation initiation factor 4A2 0.0205342
INTS6 integrator complex subunit 6 0.020501
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0203318
BBS9 Bardet-Biedl syndrome 9 0.0200492
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.0200461
RPL36A ribosomal protein L36a 0.0199125
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0196616
RACK1 receptor for activated C kinase 1 0.0194668
RPL30 ribosomal protein L30 0.019172
PDLIM5 PDZ and LIM domain 5 0.0189824
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.0188942
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0188367
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0188343
AHI1 Abelson helper integration site 1 0.0187578
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0186963
DUSP16 dual specificity phosphatase 16 0.0182988

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.193254
PTMA prothymosin, alpha -0.179981
FLNB filamin B, beta -0.126431
ANXA2 annexin A2 -0.117778
TMSB10 thymosin beta 10 -0.0982725
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0947887
FAT1 FAT atypical cadherin 1 -0.0872496
TNS4 tensin 4 -0.0842086
KRT18 keratin 18, type I -0.0833381
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0830032
KRT8 keratin 8, type II -0.069361
ASPH aspartate beta-hydroxylase -0.0660425
FTH1 ferritin, heavy polypeptide 1 -0.065689
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0648175
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0646741
CEMIP cell migration inducing protein, hyaluronan binding -0.0642929
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.064007
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0637487
GOLGA4 golgin A4 -0.0592873
ESYT2 extended synaptotagmin-like protein 2 -0.0589117
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0579534
NDRG1 N-myc downstream regulated 1 -0.05681
ITGA6 integrin, alpha 6 -0.0558389
ITGB4 integrin, beta 4 -0.0546254
VEGFA vascular endothelial growth factor A -0.0544791
LDHA lactate dehydrogenase A -0.0527393
S100A6 S100 calcium binding protein A6 -0.0526168
TPM4 tropomyosin 4 -0.0522857
PKM pyruvate kinase, muscle -0.0519417
PRELID2 PRELI domain containing 2 -0.0507188
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0503458
GREB1L growth regulation by estrogen in breast cancer-like -0.0481911
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0454063
ACTN4 actinin, alpha 4 -0.0449317
POTEF POTE ankyrin domain family, member F -0.0449178
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0440659
SLC35F3 solute carrier family 35, member F3 -0.0439779
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0437947
BIRC6 baculoviral IAP repeat containing 6 -0.04352
LOC112694756 uncharaterized LOC112694756 -0.0433603
PGK1 phosphoglycerate kinase 1 -0.0431066
AHNAK AHNAK nucleoprotein -0.0429522
RNF43 ring finger protein 43 -0.0427204
HMGA1 high mobility group AT-hook 1 -0.0426949
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.042512
PRSS3 protease, serine, 3 -0.0422729
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0420222
PPARG peroxisome proliferator-activated receptor gamma -0.0416069
EZR ezrin -0.0415886
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0415619
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0415002
MAML2 mastermind-like 2 (Drosophila) -0.0413545
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0412011
SBF2 SET binding factor 2 -0.0397785
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0391658
CCNY cyclin Y -0.0390955
CD46 CD46 molecule, complement regulatory protein -0.038754
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0386051
FERMT1 fermitin family member 1 -0.0383892
RNF217 ring finger protein 217 -0.0378903
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0378531
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0373979
MUC17 mucin 17, cell surface associated -0.0371247
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.036421
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0362665
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0359924
GMDS GDP-mannose 4,6-dehydratase -0.0350739
PTEN phosphatase and tensin homolog -0.0348764
RREB1 ras responsive element binding protein 1 -0.0347812
SREBF2 sterol regulatory element binding transcription factor 2 -0.0346277
HDLBP high density lipoprotein binding protein -0.0346166
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.03411
PTPRE protein tyrosine phosphatase, receptor type, E -0.0338185
YBX1 Y box binding protein 1 -0.0332186
NBAS neuroblastoma amplified sequence -0.0332139
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.033039
TXNRD1 thioredoxin reductase 1 -0.0327993
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 -0.0327792
KIF5B kinesin family member 5B -0.032742
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0326873
INSIG1 insulin induced gene 1 -0.0322864
NALF1 NALCN channel auxiliary factor 1 -0.0320387
FOSL1 FOS-like antigen 1 -0.0318731
CLTC clathrin, heavy chain (Hc) -0.0313808
CALB1 calbindin 1, 28kDa -0.0310289
EPHA2 EPH receptor A2 -0.0303069
GPHN gephyrin -0.0302536
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0301008
ZFAND3 zinc finger, AN1-type domain 3 -0.0291795
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0291104
PCDHB16 protocadherin beta 16 -0.0290672
DLG1 discs, large homolog 1 (Drosophila) -0.0290637
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.0285118
FAM13A family with sequence similarity 13, member A -0.0284656
STRN3 striatin, calmodulin binding protein 3 -0.0283924
SETD5 SET domain containing 5 -0.0282476
H1-0 H1.0 linker histone -0.0282459
MAP4 microtubule-associated protein 4 -0.0281682
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0281076
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0278163