9-ING-41_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 9-ING-41 perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 9-ING-41_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.125355
RPS12 ribosomal protein S12 0.0892428
RPS6 ribosomal protein S6 0.0870984
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0819428
TPT1 tumor protein, translationally-controlled 1 0.0670551
RPS2 ribosomal protein S2 0.0620329
RACK1 receptor for activated C kinase 1 0.0599899
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.058148
RPS8 ribosomal protein S8 0.0575656
RPL4 ribosomal protein L4 0.0561507
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0469302
CCSER1 coiled-coil serine-rich protein 1 0.0446426
SQSTM1 sequestosome 1 0.044433
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0427302
CANX calnexin 0.0415978
PDZD8 PDZ domain containing 8 0.0393171
LMO7 LIM domain 7 0.0377319
LOC105378220 macrophage receptor MARCO-like 0.0375943
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0374941
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0363849
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.035596
EIF1 eukaryotic translation initiation factor 1 0.0348647
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.033504
EXT1 exostosin glycosyltransferase 1 0.031975
KLF5 Kruppel-like factor 5 (intestinal) 0.0314195
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0310066
RPS27 ribosomal protein S27 0.0301963
NCOA7 nuclear receptor coactivator 7 0.0300685
NAP1L1 nucleosome assembly protein 1-like 1 0.0300621
PABPC1 poly(A) binding protein, cytoplasmic 1 0.029524
RPS3 ribosomal protein S3 0.0294961
PARD3B par-3 family cell polarity regulator beta 0.0282006
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0281704
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.0280865
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0280684
EREG epiregulin 0.0278603
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0275214
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0274718
HSPA8 heat shock 70kDa protein 8 0.0270691
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0265239
RPS20 ribosomal protein S20 0.0258403
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0254197
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.024725
EIF4A2 eukaryotic translation initiation factor 4A2 0.0226436
FBXL17 F-box and leucine-rich repeat protein 17 0.0225782
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0216859
RPLP0 ribosomal protein, large, P0 0.0214301
AREG amphiregulin 0.0212657
LURAP1L leucine rich adaptor protein 1-like 0.021071
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0210161
JAK1 Janus kinase 1 0.0209011
RIMKLB ribosomal modification protein rimK-like family member B 0.0208224
TRIM56 tripartite motif containing 56 0.0207676
BBS9 Bardet-Biedl syndrome 9 0.0206885
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0205798
MYO9A myosin IXA 0.0203986
CLIP1 CAP-GLY domain containing linker protein 1 0.0202598
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0200009
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.019926
AFF1 AF4/FMR2 family, member 1 0.0197293
DST dystonin 0.019567
EGFR epidermal growth factor receptor 0.0193805
PTPRR protein tyrosine phosphatase, receptor type, R 0.0191783
WNK1 WNK lysine deficient protein kinase 1 0.0191672
FNIP1 folliculin interacting protein 1 0.019087
RNF145 ring finger protein 145 0.0190776
DUSP16 dual specificity phosphatase 16 0.0188344
CADPS2 Ca++-dependent secretion activator 2 0.0188245
NIBAN1 niban apoptosis regulator 1 0.0187396
XPOT exportin, tRNA 0.0186565
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.018644
IARS1 isoleucyl-tRNA synthetase 1 0.0184516
ATXN1 ataxin 1 0.0184183
BPTF bromodomain PHD finger transcription factor 0.0181787
EPS8 epidermal growth factor receptor pathway substrate 8 0.0180666
MTDH metadherin 0.0179022
MYO1E myosin IE 0.0178113
ERBIN erbb2 interacting protein 0.0177666
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0176991
ANKHD1 ankyrin repeat and KH domain containing 1 0.0173598
PHF3 PHD finger protein 3 0.0172134
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0170482
RSL1D1 ribosomal L1 domain containing 1 0.016881
AGO3 argonaute RISC catalytic component 3 0.0168286
OGA O-GlcNAcase 0.0168153
TPR translocated promoter region, nuclear basket protein 0.0167334
CREBBP CREB binding protein 0.016721
EIF4B eukaryotic translation initiation factor 4B 0.016563
SMYD3 SET and MYND domain containing 3 0.0164814
WWOX WW domain containing oxidoreductase 0.0164068
UTRN utrophin 0.016396
GCLC glutamate-cysteine ligase, catalytic subunit 0.0163528
NEBL nebulette 0.0161982
RPL37 ribosomal protein L37 0.0161937
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0161759
SPON1 spondin 1, extracellular matrix protein 0.0161565
KTN1 kinectin 1 (kinesin receptor) 0.0160012
SLC38A1 solute carrier family 38, member 1 0.0159751
LGALS12 lectin, galactoside-binding, soluble, 12 0.0159175
RPL7 ribosomal protein L7 0.0158086

decreased expression

Symbol Name Standardized Value
FLNB filamin B, beta -0.202585
THSD4 thrombospondin, type I, domain containing 4 -0.195827
TMSB10 thymosin beta 10 -0.171102
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.152982
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.139905
ANXA2 annexin A2 -0.112765
CALB1 calbindin 1, 28kDa -0.103821
MSI2 musashi RNA-binding protein 2 -0.0974947
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.092163
GMDS GDP-mannose 4,6-dehydratase -0.0919502
EZR ezrin -0.0858367
MPRIP myosin phosphatase Rho interacting protein -0.0794175
ACTN4 actinin, alpha 4 -0.0786202
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.075986
PTMA prothymosin, alpha -0.0759144
P3H2 prolyl 3-hydroxylase 2 -0.0722842
F3 coagulation factor III (thromboplastin, tissue factor) -0.0714201
PKM pyruvate kinase, muscle -0.0707422
PDE4D phosphodiesterase 4D, cAMP-specific -0.0684844
KRT18 keratin 18, type I -0.0682411
POTEF POTE ankyrin domain family, member F -0.061931
ITGA6 integrin, alpha 6 -0.0615202
PSD3 pleckstrin and Sec7 domain containing 3 -0.0614175
CLDN4 claudin 4 -0.0609465
LAMA4 laminin, alpha 4 -0.0605538
ITGB4 integrin, beta 4 -0.0594787
MAML2 mastermind-like 2 (Drosophila) -0.0590221
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.057893
LDHA lactate dehydrogenase A -0.0576455
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.0574941
RBM25 RNA binding motif protein 25 -0.057343
S100A6 S100 calcium binding protein A6 -0.0568815
KRT8 keratin 8, type II -0.0568482
DENND1A DENN/MADD domain containing 1A -0.0560238
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0556583
C6ORF132 chromosome 6 open reading frame 132 -0.0554508
NPSR1 neuropeptide S receptor 1 -0.0524032
PERP PERP, TP53 apoptosis effector -0.0513713
COBL cordon-bleu WH2 repeat protein -0.0509551
ANXA11 annexin A11 -0.0509148
MYOF myoferlin -0.0495213
ZFP36L2 ZFP36 ring finger protein-like 2 -0.049477
MCU mitochondrial calcium uniporter -0.0486769
AOPEP aminopeptidase O (putative) -0.0472705
ACTG1 actin gamma 1 -0.0463902
ATP5F1B ATP synthase F1 subunit beta -0.0444745
EPHA2 EPH receptor A2 -0.0444417
CAV2 caveolin 2 -0.0444269
PTPRK protein tyrosine phosphatase, receptor type, K -0.0439785
FGD4 FYVE, RhoGEF and PH domain containing 4 -0.0439567
VCL vinculin -0.042298
AKAP13 A kinase (PRKA) anchor protein 13 -0.0417042
ETNK1 ethanolamine kinase 1 -0.0410995
UBE2H ubiquitin-conjugating enzyme E2H -0.0410006
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0408409
RAB7A RAB7A, member RAS oncogene family -0.0407436
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 -0.0397264
KRT19 keratin 19, type I -0.0396243
TPI1 triosephosphate isomerase 1 -0.0391404
DIAPH1 diaphanous-related formin 1 -0.0389557
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0381277
PRELID2 PRELI domain containing 2 -0.03806
SH3D19 SH3 domain containing 19 -0.0378978
ANO1 anoctamin 1, calcium activated chloride channel -0.0370096
NCOR2 nuclear receptor corepressor 2 -0.0368654
PALLD palladin, cytoskeletal associated protein -0.0368224
EGR1 early growth response 1 -0.0364648
DSG3 desmoglein 3 -0.0363124
ESYT2 extended synaptotagmin-like protein 2 -0.036196
MYO5B myosin VB -0.0360648
HMGA1 high mobility group AT-hook 1 -0.0355834
CARMIL1 capping protein regulator and myosin 1 linker 1 -0.0355698
RPL35A ribosomal protein L35a -0.0353015
RPS24 ribosomal protein S24 -0.0345107
PFN1 profilin 1 -0.0343086
LOC112694756 uncharaterized LOC112694756 -0.0342708
RPL32 ribosomal protein L32 -0.033887
TJP1 tight junction protein 1 -0.0337665
PRSS3 protease, serine, 3 -0.0337216
PPARG peroxisome proliferator-activated receptor gamma -0.0335499
PLAC8 placenta-specific 8 -0.0332139
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0331243
YBX1 Y box binding protein 1 -0.0330169
NFIA nuclear factor I/A -0.0327559
RPS19 ribosomal protein S19 -0.0326453
RCOR1 REST corepressor 1 -0.0322882
STK39 serine threonine kinase 39 -0.0321211
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0321091
FOXO3 forkhead box O3 -0.0320782
FOSL1 FOS-like antigen 1 -0.0319995
RAP1B RAP1B, member of RAS oncogene family -0.0318309
LAMB3 laminin, beta 3 -0.0316929
LIMA1 LIM domain and actin binding 1 -0.0315385
FERMT1 fermitin family member 1 -0.0314864
JUP junction plakoglobin -0.031426
RREB1 ras responsive element binding protein 1 -0.0307277
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.030693
TRIM2 tripartite motif containing 2 -0.0304875
KLF12 Kruppel-like factor 12 -0.0296629
RAD51B RAD51 paralog B -0.029638