9-ING-41_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 9-ING-41 perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 9-ING-41_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.202391
POTEF POTE ankyrin domain family, member F 0.098275
EEF2 eukaryotic translation elongation factor 2 0.0805636
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0708501
TXNRD1 thioredoxin reductase 1 0.0690501
VIM vimentin 0.0685707
KTN1 kinectin 1 (kinesin receptor) 0.0628947
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0588999
BIRC3 baculoviral IAP repeat containing 3 0.0571526
RPS6 ribosomal protein S6 0.0552931
RPS8 ribosomal protein S8 0.0536061
EZR ezrin 0.0502262
JMJD1C jumonji domain containing 1C 0.0486477
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0479398
FTL ferritin, light polypeptide 0.0432371
ZFP36L1 ZFP36 ring finger protein-like 1 0.0423329
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0411994
RPS27 ribosomal protein S27 0.0371227
KMT2E lysine (K)-specific methyltransferase 2E 0.0363478
MT1E metallothionein 1E 0.0347097
B2M beta-2-microglobulin 0.0328583
RPS12 ribosomal protein S12 0.0323089
MT2A metallothionein 2A 0.0320247
ISG15 ISG15 ubiquitin-like modifier 0.0314206
RPL12 ribosomal protein L12 0.0305456
AKAP9 A kinase (PRKA) anchor protein 9 0.0303954
TXNIP thioredoxin interacting protein 0.0303115
RACK1 receptor for activated C kinase 1 0.0302818
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0301647
SPAG9 sperm associated antigen 9 0.0298381
RPS19 ribosomal protein S19 0.0285647
AREG amphiregulin 0.0267996
BPTF bromodomain PHD finger transcription factor 0.0267858
SET SET nuclear proto-oncogene 0.0265349
PCBP2 poly(rC) binding protein 2 0.0262495
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0256579
UBXN4 UBX domain protein 4 0.024606
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0244965
RPS2 ribosomal protein S2 0.024229
GOLGA4 golgin A4 0.0242042
MKI67 marker of proliferation Ki-67 0.0241048
SQSTM1 sequestosome 1 0.0233445
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0233033
RPS13 ribosomal protein S13 0.0226414
MATR3 matrin 3 0.0225753
RPS14 ribosomal protein S14 0.022244
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0220555
ERBIN erbb2 interacting protein 0.0220462
BCAS3 breast carcinoma amplified sequence 3 0.0218097
PRRC2C proline-rich coiled-coil 2C 0.0216872
GOLGB1 golgin B1 0.0216853
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.021654
DARS1 aspartyl-tRNA synthetase 1 0.0216177
KDM2A lysine (K)-specific demethylase 2A 0.0215994
SYAP1 synapse associated protein 1 0.0215508
RPL23 ribosomal protein L23 0.0214452
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0211437
BRD4 bromodomain containing 4 0.0209225
COL5A2 collagen, type V, alpha 2 0.0208886
USP9X ubiquitin specific peptidase 9, X-linked 0.0208138
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0207297
WARS1 tryptophanyl-tRNA synthetase 1 0.0207074
XPO1 exportin 1 0.0206012
TPR translocated promoter region, nuclear basket protein 0.0205445
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0203094
SIK3 SIK family kinase 3 0.0201188
GPBP1 GC-rich promoter binding protein 1 0.0200894
CCDC88A coiled-coil domain containing 88A 0.0199013
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0196957
MB21D2 Mab-21 domain containing 2 0.0195839
FOSL1 FOS-like antigen 1 0.0194076
RPL39 ribosomal protein L39 0.0193537
IFITM3 interferon induced transmembrane protein 3 0.0193277
RPLP2 ribosomal protein, large, P2 0.0189535
SEC24A SEC24 family member A 0.018861
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0188519
YBX3 Y box binding protein 3 0.0187958
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0187522
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0186499
TBK1 TANK-binding kinase 1 0.0185846
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0183906
PCM1 pericentriolar material 1 0.0183734
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0183361
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.018119
HMGA1 high mobility group AT-hook 1 0.0179042
IFITM1 interferon induced transmembrane protein 1 0.017887
OPTN optineurin 0.0178197
CEP350 centrosomal protein 350kDa 0.0178064
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0177024
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0176417
P4HB prolyl 4-hydroxylase, beta polypeptide 0.017633
ARRDC3 arrestin domain containing 3 0.0175742
ZFAND3 zinc finger, AN1-type domain 3 0.0175155
PDIA3 protein disulfide isomerase family A, member 3 0.0174816
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0174623
RPL5 ribosomal protein L5 0.0172895
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0171175
SMC4 structural maintenance of chromosomes 4 0.0170832
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0170269
SEPTIN7 septin 7 0.0169445

decreased expression

Symbol Name Standardized Value
CD44 CD44 molecule (Indian blood group) -0.192524
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.149742
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.138671
PSD3 pleckstrin and Sec7 domain containing 3 -0.12942
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.128625
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.119406
ZDHHC14 zinc finger, DHHC-type containing 14 -0.115707
CADM2 cell adhesion molecule 2 -0.106058
APP amyloid beta (A4) precursor protein -0.0974827
FMNL2 formin-like 2 -0.0971252
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0967949
TM4SF1 transmembrane 4 L six family member 1 -0.0958735
EHBP1 EH domain binding protein 1 -0.0845984
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0777384
MACF1 microtubule-actin crosslinking factor 1 -0.0758458
TMSB10 thymosin beta 10 -0.0755914
ARHGAP5 Rho GTPase activating protein 5 -0.0743117
TMSB4X thymosin beta 4, X-linked -0.0732095
DLG1 discs, large homolog 1 (Drosophila) -0.0728102
BCAR3 breast cancer anti-estrogen resistance 3 -0.0706302
CSMD3 CUB and Sushi multiple domains 3 -0.0682216
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0658487
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0634397
CMIP c-Maf inducing protein -0.0630189
DOCK11 dedicator of cytokinesis 11 -0.0623109
CAPRIN2 caprin family member 2 -0.0621766
PRELID2 PRELI domain containing 2 -0.0608926
RIGI RNA sensor RIG-I -0.0606373
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0595349
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0588578
PDE10A phosphodiesterase 10A -0.0570705
DENND1A DENN/MADD domain containing 1A -0.0566946
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0557998
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0542132
STK17A serine/threonine kinase 17a -0.054211
EFNA5 ephrin-A5 -0.053493
SDK1 sidekick cell adhesion molecule 1 -0.0534419
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0500016
DST dystonin -0.0486069
DNER delta/notch-like EGF repeat containing -0.0477963
THSD4 thrombospondin, type I, domain containing 4 -0.0471263
CFAP299 cilia and flagella associated protein 299 -0.0470804
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0459318
STAT1 signal transducer and activator of transcription 1, 91kDa -0.044024
LRRC49 leucine rich repeat containing 49 -0.0430854
TNS3 tensin 3 -0.0429609
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0426867
LPP LIM domain containing preferred translocation partner in lipoma -0.0424475
LOXL2 lysyl oxidase-like 2 -0.0423516
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0406432
PTPRF protein tyrosine phosphatase, receptor type, F -0.0406281
VCL vinculin -0.0404564
NT5E 5'-nucleotidase, ecto (CD73) -0.0395979
FLNB filamin B, beta -0.038056
KDM4B lysine (K)-specific demethylase 4B -0.0375975
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 -0.0371846
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0371142
ZNF217 zinc finger protein 217 -0.0368858
TRIO trio Rho guanine nucleotide exchange factor -0.0368552
AEBP2 AE binding protein 2 -0.0358752
PTK2 protein tyrosine kinase 2 -0.0358692
HPCAL1 hippocalcin-like 1 -0.0353401
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0344418
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0342768
NEK10 NIMA-related kinase 10 -0.0342383
NHSL1 NHS-like 1 -0.0340302
TTC28 tetratricopeptide repeat domain 28 -0.0336598
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0336329
NAV2 neuron navigator 2 -0.0334026
KDM4C lysine (K)-specific demethylase 4C -0.0333647
OSMR oncostatin M receptor -0.0332198
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0328039
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.031844
TSC22D1 TSC22 domain family, member 1 -0.0318075
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0316602
HLA-B major histocompatibility complex, class I, B -0.031483
LDHA lactate dehydrogenase A -0.0311397
EGFR epidermal growth factor receptor -0.0310731
IGF1R insulin-like growth factor 1 receptor -0.0304417
RAP2B RAP2B, member of RAS oncogene family -0.0302888
RAD51B RAD51 paralog B -0.0301469
TBC1D22A TBC1 domain family, member 22A -0.0300336
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0299493
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0296717
NPAS2 neuronal PAS domain protein 2 -0.0295571
DOCK1 dedicator of cytokinesis 1 -0.0293224
ANKRD11 ankyrin repeat domain 11 -0.0292909
EXOC4 exocyst complex component 4 -0.0289799
CCDC91 coiled-coil domain containing 91 -0.0287325
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0287204
SMAD3 SMAD family member 3 -0.0281347
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0278623
AHNAK AHNAK nucleoprotein -0.0274656
INTS6 integrator complex subunit 6 -0.0273563
MCTP1 multiple C2 domains, transmembrane 1 -0.0270147
MTCL1 microtubule crosslinking factor 1 -0.0269063
TAS2R14 taste receptor, type 2, member 14 -0.0266006
PYGL phosphorylase, glycogen, liver -0.0264828
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0264371
TPT1 tumor protein, translationally-controlled 1 -0.0263329