9-ING-41_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 9-ING-41 perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 9-ING-41_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.158601
STC1 stanniocalcin 1 0.0753485
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0668079
TPT1 tumor protein, translationally-controlled 1 0.0642397
NAMPT nicotinamide phosphoribosyltransferase 0.0583221
ELL2 elongation factor, RNA polymerase II, 2 0.0498109
EEF2 eukaryotic translation elongation factor 2 0.0496345
CANX calnexin 0.047434
SPAG9 sperm associated antigen 9 0.0459514
AGO2 argonaute RISC catalytic component 2 0.043858
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0434328
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0420976
CXCL8 chemokine (C-X-C motif) ligand 8 0.0411552
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0409411
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0407501
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0405171
ERRFI1 ERBB receptor feedback inhibitor 1 0.0398552
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0391347
BIRC3 baculoviral IAP repeat containing 3 0.0389602
EIF1 eukaryotic translation initiation factor 1 0.0381786
SQSTM1 sequestosome 1 0.0354401
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0347991
JMJD1C jumonji domain containing 1C 0.0336661
SOD2 superoxide dismutase 2, mitochondrial 0.0330664
ENO1 enolase 1, (alpha) 0.0329273
SP100 SP100 nuclear antigen 0.0318275
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0305104
BMP6 bone morphogenetic protein 6 0.0302305
EIF4A2 eukaryotic translation initiation factor 4A2 0.0294726
GOLGB1 golgin B1 0.0294044
OGA O-GlcNAcase 0.0293846
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0290428
DSCAM Down syndrome cell adhesion molecule 0.027644
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0276104
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0272137
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.026881
PDIA3 protein disulfide isomerase family A, member 3 0.0266862
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0262408
RPLP0 ribosomal protein, large, P0 0.026146
RPS6 ribosomal protein S6 0.0258985
RPS8 ribosomal protein S8 0.0253529
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0253037
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0252559
RICTOR RPTOR independent companion of MTOR, complex 2 0.0251049
UBC ubiquitin C 0.0248211
NAP1L1 nucleosome assembly protein 1-like 1 0.0247353
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0246398
HBP1 HMG-box transcription factor 1 0.0240301
NSUN6 NOP2/Sun domain family, member 6 0.0238899
RPL4 ribosomal protein L4 0.0237151
CEMIP cell migration inducing protein, hyaluronan binding 0.0233716
RPS2 ribosomal protein S2 0.023256
FNIP1 folliculin interacting protein 1 0.0229281
TRIM56 tripartite motif containing 56 0.0228179
NIPBL Nipped-B homolog (Drosophila) 0.0221198
YTHDC1 YTH domain containing 1 0.0216355
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.021551
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0214292
RPS12 ribosomal protein S12 0.0207456
FTL ferritin, light polypeptide 0.0205201
MCTP1 multiple C2 domains, transmembrane 1 0.0204006
AREG amphiregulin 0.0199757
GOLGA4 golgin A4 0.0199615
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0198409
AKAP9 A kinase (PRKA) anchor protein 9 0.0194065
ATF6 activating transcription factor 6 0.0192607
RPL7 ribosomal protein L7 0.0190997
ANKHD1 ankyrin repeat and KH domain containing 1 0.0189525
HLA-E major histocompatibility complex, class I, E 0.0188037
RPS3 ribosomal protein S3 0.018653
MYO6 myosin VI 0.0185883
SEC31A SEC31 homolog A (S. cerevisiae) 0.0185742
BPTF bromodomain PHD finger transcription factor 0.0184562
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0184399
BTG1 B-cell translocation gene 1, anti-proliferative 0.0180908
RAB1A RAB1A, member RAS oncogene family 0.0179582
MCL1 myeloid cell leukemia 1 0.0179129
PDIA6 protein disulfide isomerase family A, member 6 0.0178146
C15ORF48 chromosome 15 open reading frame 48 0.0177997
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0173803
ARGLU1 arginine and glutamate rich 1 0.0166966
RPS27 ribosomal protein S27 0.01644
KDM3A lysine (K)-specific demethylase 3A 0.0163979
JAK1 Janus kinase 1 0.0162783
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0161693
TBC1D15 TBC1 domain family, member 15 0.0160017
TOP1 topoisomerase (DNA) I 0.0157567
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0156132
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0154951
ARRDC3 arrestin domain containing 3 0.0154182
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.015407
TMCO3 transmembrane and coiled-coil domains 3 0.0154012
TPR translocated promoter region, nuclear basket protein 0.0152349
RPLP1 ribosomal protein, large, P1 0.015232
KIF5B kinesin family member 5B 0.0150718
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0150251
WWOX WW domain containing oxidoreductase 0.0149745
PNPLA8 patatin-like phospholipase domain containing 8 0.0148329
KYNU kynureninase 0.0148251
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0148183

decreased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor -0.453897
ASPH aspartate beta-hydroxylase -0.238074
PTPRM protein tyrosine phosphatase, receptor type, M -0.20993
THSD4 thrombospondin, type I, domain containing 4 -0.160463
TMSB10 thymosin beta 10 -0.157182
CAV1 caveolin 1, caveolae protein, 22kDa -0.083542
SCEL sciellin -0.0779834
PDLIM5 PDZ and LIM domain 5 -0.0747952
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0675551
EFNA5 ephrin-A5 -0.0619462
PKM pyruvate kinase, muscle -0.0592773
PDE4D phosphodiesterase 4D, cAMP-specific -0.0584588
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0573626
GSK3B glycogen synthase kinase 3 beta -0.0542313
OSMR oncostatin M receptor -0.053525
LDHA lactate dehydrogenase A -0.0512363
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0506758
VCL vinculin -0.0491056
FLNB filamin B, beta -0.0480995
KRT7 keratin 7, type II -0.0469231
MAML3 mastermind-like 3 (Drosophila) -0.0460045
LMO7 LIM domain 7 -0.0459191
NPAS2 neuronal PAS domain protein 2 -0.0453856
IGFBP5 insulin-like growth factor binding protein 5 -0.0453293
INTS6 integrator complex subunit 6 -0.0447673
LAMC2 laminin, gamma 2 -0.0443498
LAMA4 laminin, alpha 4 -0.0423046
S100A10 S100 calcium binding protein A10 -0.0418628
ARHGAP32 Rho GTPase activating protein 32 -0.0413145
CST3 cystatin C -0.0405353
GPC6 glypican 6 -0.0401805
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0393309
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0390366
RAB27B RAB27B, member RAS oncogene family -0.0390301
FNDC3B fibronectin type III domain containing 3B -0.0384251
TNS3 tensin 3 -0.0382728
MCU mitochondrial calcium uniporter -0.0371823
NDRG1 N-myc downstream regulated 1 -0.0370816
POTEF POTE ankyrin domain family, member F -0.0359511
KRT18 keratin 18, type I -0.0357968
NRIP1 nuclear receptor interacting protein 1 -0.0350387
ACTG1 actin gamma 1 -0.0346273
EGR1 early growth response 1 -0.034514
MYO1D myosin ID -0.0342944
CMIP c-Maf inducing protein -0.0340269
PRKCA protein kinase C, alpha -0.0334766
ATP11A ATPase, class VI, type 11A -0.0331477
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0326738
KRT8 keratin 8, type II -0.032169
TXNRD1 thioredoxin reductase 1 -0.0320536
PTK2 protein tyrosine kinase 2 -0.0319214
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0311891
CAV2 caveolin 2 -0.0305106
GRAMD1B GRAM domain containing 1B -0.030224
SUMF1 sulfatase modifying factor 1 -0.0299266
LPP LIM domain containing preferred translocation partner in lipoma -0.0295353
CCND1 cyclin D1 -0.029386
ANXA2 annexin A2 -0.0289921
MYH9 myosin, heavy chain 9, non-muscle -0.0289351
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0286446
TAS2R14 taste receptor, type 2, member 14 -0.0278316
PSD3 pleckstrin and Sec7 domain containing 3 -0.0276505
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0276479
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0270576
IGF1R insulin-like growth factor 1 receptor -0.0269471
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0268254
AKAP13 A kinase (PRKA) anchor protein 13 -0.0266677
SLC35F3 solute carrier family 35, member F3 -0.0265546
PATJ PATJ crumbs cell polarity complex component -0.0263553
RCOR1 REST corepressor 1 -0.0257035
SBF2 SET binding factor 2 -0.0254657
MAML2 mastermind-like 2 (Drosophila) -0.0252259
GRB10 growth factor receptor-bound protein 10 -0.0248377
PFN1 profilin 1 -0.0243248
CUX1 cut-like homeobox 1 -0.0243193
CNTN1 contactin 1 -0.0237973
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0237949
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0233885
NTSR1 neurotensin receptor 1 (high affinity) -0.0231919
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma -0.0229081
TMOD3 tropomodulin 3 (ubiquitous) -0.0228196
RIN2 Ras and Rab interactor 2 -0.022766
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0226263
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -0.0224946
TBC1D5 TBC1 domain family, member 5 -0.0224745
MYOF myoferlin -0.0224013
VEGFC vascular endothelial growth factor C -0.0222926
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.022152
EHBP1 EH domain binding protein 1 -0.0221515
PLS3 plastin 3 -0.0219526
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0219397
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 -0.0218056
AMOTL1 angiomotin like 1 -0.0217768
LAMA5 laminin, alpha 5 -0.0216628
PLEC plectin -0.021245
ZMYM2 zinc finger, MYM-type 2 -0.0212338
MSN moesin -0.0211957
MACF1 microtubule-actin crosslinking factor 1 -0.0211847
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0210097
CTBP2 C-terminal binding protein 2 -0.0209825