9-ING-41_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 9-ING-41 perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 9-ING-41_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.183515
VIM vimentin 0.143266
AKAP12 A kinase (PRKA) anchor protein 12 0.0975306
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0888953
NTN4 netrin 4 0.0805598
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0744636
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0680138
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0678447
RPS12 ribosomal protein S12 0.0674014
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0673679
ENO1 enolase 1, (alpha) 0.0667477
B2M beta-2-microglobulin 0.0663405
SQSTM1 sequestosome 1 0.0660426
RPS6 ribosomal protein S6 0.0656873
IFI6 interferon, alpha-inducible protein 6 0.0619422
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0617345
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0600675
RPS8 ribosomal protein S8 0.0592559
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0567607
RPL37A ribosomal protein L37a 0.0544538
EXT1 exostosin glycosyltransferase 1 0.0538656
RAD51B RAD51 paralog B 0.0533069
KYNU kynureninase 0.0522189
ANGPTL4 angiopoietin-like 4 0.0499508
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0494896
TPT1 tumor protein, translationally-controlled 1 0.0486251
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0476857
SAMD9 sterile alpha motif domain containing 9 0.0466111
EEF2 eukaryotic translation elongation factor 2 0.0463527
RPL31 ribosomal protein L31 0.0450986
RPS17 ribosomal protein S17 0.0449225
RPS29 ribosomal protein S29 0.0432213
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0431317
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0430783
LRMDA leucine rich melanocyte differentiation associated 0.0427974
EIF1 eukaryotic translation initiation factor 1 0.0420734
ZSWIM6 zinc finger, SWIM-type containing 6 0.041436
IFI44L interferon-induced protein 44-like 0.0408618
RPL37 ribosomal protein L37 0.0397656
RPS3 ribosomal protein S3 0.0396671
RPL23 ribosomal protein L23 0.0395091
BPTF bromodomain PHD finger transcription factor 0.0394224
RACK1 receptor for activated C kinase 1 0.0390231
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0389115
HDAC9 histone deacetylase 9 0.038567
CD44 CD44 molecule (Indian blood group) 0.037551
SOD2 superoxide dismutase 2, mitochondrial 0.0374714
NAP1L1 nucleosome assembly protein 1-like 1 0.0370728
MT2A metallothionein 2A 0.0367434
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0363529
RPS19 ribosomal protein S19 0.0348523
INTS6 integrator complex subunit 6 0.0346907
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0346093
RPS27 ribosomal protein S27 0.0344433
ECE1 endothelin converting enzyme 1 0.0340566
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0340117
RPL35A ribosomal protein L35a 0.0334835
ALCAM activated leukocyte cell adhesion molecule 0.0329241
SP100 SP100 nuclear antigen 0.0329108
RPS13 ribosomal protein S13 0.0327959
LOC102724023 ES1 protein homolog, mitochondrial 0.0325756
EHBP1 EH domain binding protein 1 0.0324332
FTL ferritin, light polypeptide 0.0320812
RPL34 ribosomal protein L34 0.0318309
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0317238
PLIN2 perilipin 2 0.0316423
AADAC arylacetamide deacetylase 0.0315601
TIMP1 TIMP metallopeptidase inhibitor 1 0.0312983
RPL11 ribosomal protein L11 0.0312109
LHFPL2 lipoma HMGIC fusion partner-like 2 0.030873
RPL32 ribosomal protein L32 0.0302821
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0295072
RPL36 ribosomal protein L36 0.0292108
SFTPA2 surfactant protein A2 0.0288998
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0288812
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0286992
SUMF1 sulfatase modifying factor 1 0.0283883
GLCCI1 glucocorticoid induced 1 0.0283571
RASAL2 RAS protein activator like 2 0.0280155
RPS25 ribosomal protein S25 0.027575
IFITM3 interferon induced transmembrane protein 3 0.0275025
MX2 MX dynamin-like GTPase 2 0.0272644
RPLP1 ribosomal protein, large, P1 0.0272114
RPS23 ribosomal protein S23 0.0268525
CA12 carbonic anhydrase XII 0.0267219
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0264582
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0264329
ANKRD28 ankyrin repeat domain 28 0.0262726
PHF14 PHD finger protein 14 0.0258558
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0256981
RPL12 ribosomal protein L12 0.0256383
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0252946
RND3 Rho family GTPase 3 0.0249796
SEPTIN9 septin 9 0.0248489
FNIP1 folliculin interacting protein 1 0.0247246
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.02456
SLC38A2 solute carrier family 38, member 2 0.0244597
IFI27 interferon, alpha-inducible protein 27 0.0243685
ZFHX3 zinc finger homeobox 3 0.024238
RPLP2 ribosomal protein, large, P2 0.0241919

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.20647
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.174393
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.124935
RBM39 RNA binding motif protein 39 -0.105819
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0998115
SDK1 sidekick cell adhesion molecule 1 -0.0923297
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0922752
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0879693
GOLGA4 golgin A4 -0.0824143
KDM2A lysine (K)-specific demethylase 2A -0.078296
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0747853
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0731023
KMT2C lysine (K)-specific methyltransferase 2C -0.0687032
IGFBP3 insulin-like growth factor binding protein 3 -0.0662084
ELL2 elongation factor, RNA polymerase II, 2 -0.0645779
OSMR oncostatin M receptor -0.0604967
DLG1 discs, large homolog 1 (Drosophila) -0.0598037
UBA6 ubiquitin-like modifier activating enzyme 6 -0.059744
GRB10 growth factor receptor-bound protein 10 -0.0594928
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0585407
TMSB10 thymosin beta 10 -0.0574887
FAM13A family with sequence similarity 13, member A -0.0547029
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0537203
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0518892
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.048929
LMAN1 lectin, mannose-binding, 1 -0.0481608
PDE4D phosphodiesterase 4D, cAMP-specific -0.0478567
USP3 ubiquitin specific peptidase 3 -0.0474226
KDM3A lysine (K)-specific demethylase 3A -0.0469922
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0464165
COG5 component of oligomeric golgi complex 5 -0.0439987
SETD5 SET domain containing 5 -0.0433588
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0427448
OGA O-GlcNAcase -0.0426029
ZNF292 zinc finger protein 292 -0.0425722
BIRC6 baculoviral IAP repeat containing 6 -0.0424579
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0415509
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0413978
MEF2A myocyte enhancer factor 2A -0.0412076
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0403872
ATP13A3 ATPase type 13A3 -0.0403477
RAB1A RAB1A, member RAS oncogene family -0.0401498
NPC1 Niemann-Pick disease, type C1 -0.0394178
SRP54 signal recognition particle 54kDa -0.0393095
PCBP2 poly(rC) binding protein 2 -0.0392449
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0390191
SPAG9 sperm associated antigen 9 -0.0387413
COPA coatomer protein complex, subunit alpha -0.0383955
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0381416
HDLBP high density lipoprotein binding protein -0.0377394
CDH13 cadherin 13 -0.0372164
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0358801
PTMA prothymosin, alpha -0.0356931
MRPS6 mitochondrial ribosomal protein S6 -0.0356339
PDIA3 protein disulfide isomerase family A, member 3 -0.03559
SEC23A Sec23 homolog A (S. cerevisiae) -0.035411
FTH1 ferritin, heavy polypeptide 1 -0.0351343
YBX1 Y box binding protein 1 -0.0351144
PARP8 poly (ADP-ribose) polymerase family, member 8 -0.0346874
RAP1B RAP1B, member of RAS oncogene family -0.0346255
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0338612
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0336886
HELZ helicase with zinc finger -0.0335807
NBAS neuroblastoma amplified sequence -0.0334629
ZFAND3 zinc finger, AN1-type domain 3 -0.0334272
SUCO SUN domain containing ossification factor -0.0329378
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0323729
WDR45B WD repeat domain 45B -0.0321867
ARF4 ADP-ribosylation factor 4 -0.032
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0318319
FBXL13 F-box and leucine-rich repeat protein 13 -0.031765
AKAP13 A kinase (PRKA) anchor protein 13 -0.0315588
FAM20C family with sequence similarity 20, member C -0.0315547
MTSS1 metastasis suppressor 1 -0.0311797
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -0.0305677
CD109 CD109 molecule -0.0300885
PIAS2 protein inhibitor of activated STAT, 2 -0.0299492
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0293112
RNF145 ring finger protein 145 -0.0292728
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0291033
STRN3 striatin, calmodulin binding protein 3 -0.0288423
EFNA5 ephrin-A5 -0.0288041
NGLY1 N-glycanase 1 -0.0287505
SS18 synovial sarcoma translocation, chromosome 18 -0.0286461
TMEM263 transmembrane protein 263 -0.028588
RB1CC1 RB1-inducible coiled-coil 1 -0.0285811
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0285056
BLZF1 basic leucine zipper nuclear factor 1 -0.0283032
ITCH itchy E3 ubiquitin protein ligase -0.0279637
MON2 MON2 homolog (S. cerevisiae) -0.0278449
JMJD1C jumonji domain containing 1C -0.0278321
PRRC2C proline-rich coiled-coil 2C -0.027261
FOXO3 forkhead box O3 -0.027176
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0271142
MARCHF6 membrane associated ring-CH-type finger 6 -0.02709
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0270736
LCORL ligand dependent nuclear receptor corepressor-like -0.0267132
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0267034
ACBD3 acyl-CoA binding domain containing 3 -0.0265542
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0265526