9-ING-41_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 9-ING-41 perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the 9-ING-41_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PM20D1 peptidase M20 domain containing 1 0.201916
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.134944
EIF1 eukaryotic translation initiation factor 1 0.110386
TXNRD1 thioredoxin reductase 1 0.103105
MT2A metallothionein 2A 0.0965559
RPS12 ribosomal protein S12 0.0765495
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0759944
VIM vimentin 0.071385
NTN4 netrin 4 0.0504283
RPS3 ribosomal protein S3 0.0450137
RPL23 ribosomal protein L23 0.0446213
EEF2 eukaryotic translation elongation factor 2 0.0444103
RPL19 ribosomal protein L19 0.0436635
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0421988
PDE4D phosphodiesterase 4D, cAMP-specific 0.041695
RPL26 ribosomal protein L26 0.0407938
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0407566
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0406007
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0397338
WWOX WW domain containing oxidoreductase 0.0379016
MKI67 marker of proliferation Ki-67 0.0375891
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0367492
RPL7 ribosomal protein L7 0.0362916
RPL18 ribosomal protein L18 0.0354364
FGB fibrinogen beta chain 0.035314
RACK1 receptor for activated C kinase 1 0.0351134
RPL37A ribosomal protein L37a 0.0345223
RPS17 ribosomal protein S17 0.0342355
TPT1 tumor protein, translationally-controlled 1 0.033548
SQSTM1 sequestosome 1 0.0331801
RPS2 ribosomal protein S2 0.0331441
KYNU kynureninase 0.033066
AKAP12 A kinase (PRKA) anchor protein 12 0.0319975
RPS8 ribosomal protein S8 0.0319824
AHR aryl hydrocarbon receptor 0.0309974
RPL12 ribosomal protein L12 0.0309178
FGG fibrinogen gamma chain 0.0303768
RPS27A ribosomal protein S27a 0.0298867
B2M beta-2-microglobulin 0.0292994
KLF6 Kruppel-like factor 6 0.0286958
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0286943
RPS6 ribosomal protein S6 0.0286595
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0279334
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0274072
RPL8 ribosomal protein L8 0.0258849
RPLP0 ribosomal protein, large, P0 0.0257134
RPL32 ribosomal protein L32 0.0253582
C15ORF48 chromosome 15 open reading frame 48 0.0253329
KIF5B kinesin family member 5B 0.0243516
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.024339
RPL4 ribosomal protein L4 0.0243114
RPL36 ribosomal protein L36 0.0236608
FTL ferritin, light polypeptide 0.0228935
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0228866
RPS5 ribosomal protein S5 0.0221727
ENO1 enolase 1, (alpha) 0.0221219
ANXA1 annexin A1 0.0219085
TNPO1 transportin 1 0.0217134
RPS19 ribosomal protein S19 0.0211439
NFE2L2 nuclear factor, erythroid 2-like 2 0.0211139
NAMPT nicotinamide phosphoribosyltransferase 0.021074
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0208896
NIPBL Nipped-B homolog (Drosophila) 0.0208203
RPL37 ribosomal protein L37 0.0204356
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0201301
SLC38A2 solute carrier family 38, member 2 0.0198608
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0192046
SERINC1 serine incorporator 1 0.0189017
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) 0.0186118
RPL30 ribosomal protein L30 0.0185052
CLU clusterin 0.0183618
RPL10A ribosomal protein L10a 0.0181641
BIRC3 baculoviral IAP repeat containing 3 0.0181052
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0181023
NNMT nicotinamide N-methyltransferase 0.0174644
RPS23 ribosomal protein S23 0.0170824
KIAA0319 KIAA0319 0.0169823
HSPB1 heat shock 27kDa protein 1 0.01692
TFPI2 tissue factor pathway inhibitor 2 0.0168577
RPL23A ribosomal protein L23a 0.0164938
RPS27 ribosomal protein S27 0.0162076
UBB ubiquitin B 0.0157803
HSPA8 heat shock 70kDa protein 8 0.0156786
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 0.0156331
IGF1R insulin-like growth factor 1 receptor 0.0155986
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 0.0155386
RSPO3 R-spondin 3 0.015434
BMP5 bone morphogenetic protein 5 0.0154216
FGA fibrinogen alpha chain 0.015386
SET SET nuclear proto-oncogene 0.0153776
PNRC1 proline-rich nuclear receptor coactivator 1 0.01522
NUSAP1 nucleolar and spindle associated protein 1 0.0149285
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0148958
RAD21 RAD21 homolog (S. pombe) 0.0148782
RPS20 ribosomal protein S20 0.0148313
FBXL20 F-box and leucine-rich repeat protein 20 0.0145358
RTN4 reticulon 4 0.0144162
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.0142222
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.0141899
TPD52 tumor protein D52 0.0141178

decreased expression

Symbol Name Standardized Value
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.21175
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.184198
THSD4 thrombospondin, type I, domain containing 4 -0.139156
DOCK4 dedicator of cytokinesis 4 -0.116888
POTEF POTE ankyrin domain family, member F -0.116196
CMIP c-Maf inducing protein -0.106705
SAMD4A sterile alpha motif domain containing 4A -0.101525
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0906803
FMNL2 formin-like 2 -0.0773865
IGFBP3 insulin-like growth factor binding protein 3 -0.0735711
TMSB10 thymosin beta 10 -0.0708904
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0699072
FTH1 ferritin, heavy polypeptide 1 -0.0681124
MCL1 myeloid cell leukemia 1 -0.0673224
COPA coatomer protein complex, subunit alpha -0.0663462
FLNB filamin B, beta -0.0660772
EGR1 early growth response 1 -0.0657783
ANKRD11 ankyrin repeat domain 11 -0.064615
EGFR epidermal growth factor receptor -0.0606233
PYGL phosphorylase, glycogen, liver -0.0574551
UBASH3B ubiquitin associated and SH3 domain containing B -0.0559924
TRIO trio Rho guanine nucleotide exchange factor -0.0557062
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0516221
ARHGAP26 Rho GTPase activating protein 26 -0.0489376
PARD3 par-3 family cell polarity regulator -0.0474766
ACTN1 actinin, alpha 1 -0.0474272
ZFAND3 zinc finger, AN1-type domain 3 -0.0443391
PTK2 protein tyrosine kinase 2 -0.0433082
PKM pyruvate kinase, muscle -0.0415428
NDRG1 N-myc downstream regulated 1 -0.0411438
EXT1 exostosin glycosyltransferase 1 -0.0410893
CTBP2 C-terminal binding protein 2 -0.0406745
RERE arginine-glutamic acid dipeptide (RE) repeats -0.039759
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0395054
ACTG1 actin gamma 1 -0.0387521
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0380378
WAC WW domain containing adaptor with coiled-coil -0.0379936
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0370114
RBM25 RNA binding motif protein 25 -0.0365904
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0363606
FNDC3B fibronectin type III domain containing 3B -0.0361945
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0361176
PTMA prothymosin, alpha -0.0360557
NHSL1 NHS-like 1 -0.0355633
PUM2 pumilio RNA-binding family member 2 -0.0345555
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0342582
MAML3 mastermind-like 3 (Drosophila) -0.0342461
CCNL1 cyclin L1 -0.0340814
FBXO11 F-box protein 11 -0.0338309
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0334465
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0333239
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0330602
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0328429
ZNF207 zinc finger protein 207 -0.0323236
PRR16 proline rich 16 -0.0320993
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0320633
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0318673
NAV3 neuron navigator 3 -0.0317726
RAB7A RAB7A, member RAS oncogene family -0.0312831
SLC35F3 solute carrier family 35, member F3 -0.0312772
IGFBP4 insulin-like growth factor binding protein 4 -0.0310604
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0309026
RAP1GAP2 RAP1 GTPase activating protein 2 -0.0305907
ARF4 ADP-ribosylation factor 4 -0.030574
UTRN utrophin -0.0303183
APP amyloid beta (A4) precursor protein -0.0303139
ERBIN erbb2 interacting protein -0.0301505
TPM1 tropomyosin 1 (alpha) -0.029853
ELL2 elongation factor, RNA polymerase II, 2 -0.0298064
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0294899
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0294168
DOCK5 dedicator of cytokinesis 5 -0.0292991
RAD51B RAD51 paralog B -0.0292813
RBM39 RNA binding motif protein 39 -0.0289722
GSK3B glycogen synthase kinase 3 beta -0.0289368
SETD5 SET domain containing 5 -0.0288069
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0287914
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.0286638
MAP1B microtubule-associated protein 1B -0.0281892
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0281017
TPM4 tropomyosin 4 -0.0280125
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0277268
DST dystonin -0.0273051
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0268372
GOLGA4 golgin A4 -0.0267305
CALR calreticulin -0.0263782
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0263472
BIRC6 baculoviral IAP repeat containing 6 -0.0263199
MACF1 microtubule-actin crosslinking factor 1 -0.0262003
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0257961
PFN1 profilin 1 -0.0256156
TOP1 topoisomerase (DNA) I -0.025514
CFAP73 cilia and flagella associated protein 73 -0.025413
TGM2 transglutaminase 2 -0.0252345
SBF2 SET binding factor 2 -0.0251953
SNX14 sorting nexin 14 -0.024964
NLK nemo-like kinase -0.0249372
MSN moesin -0.0247643
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0245373
DENND4A DENN/MADD domain containing 4A -0.0244264