9-ING-41_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 9-ING-41 perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 9-ING-41_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0926583
PTMA prothymosin, alpha 0.0767026
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0698588
EEF2 eukaryotic translation elongation factor 2 0.0638224
TPT1 tumor protein, translationally-controlled 1 0.0609135
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0562925
RPS8 ribosomal protein S8 0.0502589
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0478581
RPL35A ribosomal protein L35a 0.0462046
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0436526
HLA-B major histocompatibility complex, class I, B 0.0436462
RPL23 ribosomal protein L23 0.0428687
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0406389
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0381985
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0374357
AKAP12 A kinase (PRKA) anchor protein 12 0.0372269
RPL31 ribosomal protein L31 0.0367164
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0359985
CANX calnexin 0.035888
RPLP1 ribosomal protein, large, P1 0.0358242
IFI6 interferon, alpha-inducible protein 6 0.0351355
AEBP2 AE binding protein 2 0.0343221
RPS27A ribosomal protein S27a 0.0333473
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0333271
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0323283
RPL37 ribosomal protein L37 0.0320907
TFPI2 tissue factor pathway inhibitor 2 0.031735
RPLP0 ribosomal protein, large, P0 0.0308939
CAVIN1 caveolae associated protein 1 0.0302406
RPL38 ribosomal protein L38 0.0299278
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0297242
RPL11 ribosomal protein L11 0.0295461
ENO1 enolase 1, (alpha) 0.027182
NAP1L1 nucleosome assembly protein 1-like 1 0.0269528
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0265393
RPL34 ribosomal protein L34 0.0258347
GOLGB1 golgin B1 0.0256507
HSPH1 heat shock 105kDa/110kDa protein 1 0.0256217
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0252004
RPL37A ribosomal protein L37a 0.0250948
RIMS2 regulating synaptic membrane exocytosis 2 0.0249706
VIM vimentin 0.0245531
RPS13 ribosomal protein S13 0.0242985
RPL7A ribosomal protein L7a 0.0241969
STAU1 staufen double-stranded RNA binding protein 1 0.0238925
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0238512
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0237057
RPS24 ribosomal protein S24 0.0236663
IER3 immediate early response 3 0.0235672
GNAS GNAS complex locus 0.0234988
WWOX WW domain containing oxidoreductase 0.0226832
RPS21 ribosomal protein S21 0.0226091
RPS27 ribosomal protein S27 0.0222587
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0220211
SQSTM1 sequestosome 1 0.0215266
BZW1 basic leucine zipper and W2 domains 1 0.0215125
IL6ST interleukin 6 signal transducer 0.0214426
DSPP dentin sialophosphoprotein 0.0213724
CALR calreticulin 0.0212347
PATJ PATJ crumbs cell polarity complex component 0.0209445
FTL ferritin, light polypeptide 0.0209323
PDIA4 protein disulfide isomerase family A, member 4 0.0204523
FUS FUS RNA binding protein 0.0204037
RPS29 ribosomal protein S29 0.0203394
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0203318
RPL4 ribosomal protein L4 0.0199081
RPS10 ribosomal protein S10 0.0196615
NIPBL Nipped-B homolog (Drosophila) 0.0196165
RAB1A RAB1A, member RAS oncogene family 0.0195204
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0193784
RPL36A ribosomal protein L36a 0.0192905
RPS20 ribosomal protein S20 0.0190863
RPS16 ribosomal protein S16 0.0190791
VCP valosin containing protein 0.0190771
CDK12 cyclin-dependent kinase 12 0.0189577
PRELID2 PRELI domain containing 2 0.0189406
B2M beta-2-microglobulin 0.0185316
CUX1 cut-like homeobox 1 0.0184629
RPL12 ribosomal protein L12 0.0184563
BPTF bromodomain PHD finger transcription factor 0.0184099
RPL39 ribosomal protein L39 0.0184062
RACK1 receptor for activated C kinase 1 0.0177997
TPM4 tropomyosin 4 0.0174973
HOMER1 homer scaffolding protein 1 0.0173963
SRP72 signal recognition particle 72kDa 0.0172456
UBB ubiquitin B 0.0171324
RPS6 ribosomal protein S6 0.0171253
RPL13A ribosomal protein L13a 0.0166885
RPL30 ribosomal protein L30 0.0165197
NEK10 NIMA-related kinase 10 0.0164371
INTS6 integrator complex subunit 6 0.01636
RPS25 ribosomal protein S25 0.0163226
ZSWIM6 zinc finger, SWIM-type containing 6 0.0162563
SFTPA2 surfactant protein A2 0.0161588
RPL26 ribosomal protein L26 0.016028
RPS19 ribosomal protein S19 0.0160081
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0159154
LRP1B low density lipoprotein receptor-related protein 1B 0.0159037
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0158538
RPL8 ribosomal protein L8 0.015846

decreased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 -0.13502
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0860893
TRIO trio Rho guanine nucleotide exchange factor -0.0826796
OSMR oncostatin M receptor -0.0746217
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0695977
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0695533
NABP1 nucleic acid binding protein 1 -0.067354
CCNL1 cyclin L1 -0.0618692
EGR1 early growth response 1 -0.0608496
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0596294
RAD51B RAD51 paralog B -0.0595926
MARCHF4 membrane associated ring-CH-type finger 4 -0.0592363
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0568278
THSD4 thrombospondin, type I, domain containing 4 -0.0556271
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0534773
RTN4 reticulon 4 -0.0528445
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0525738
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0502694
CDK17 cyclin-dependent kinase 17 -0.0491782
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0487295
SBF2 SET binding factor 2 -0.0464646
POTEF POTE ankyrin domain family, member F -0.0459966
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0459841
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0449679
SMAD3 SMAD family member 3 -0.0433299
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0429041
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0422718
GRAMD1B GRAM domain containing 1B -0.0417652
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.040784
EML4 echinoderm microtubule associated protein like 4 -0.0406428
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0401613
ATP11A ATPase, class VI, type 11A -0.0397207
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0394752
KCMF1 potassium channel modulatory factor 1 -0.038987
GATAD2B GATA zinc finger domain containing 2B -0.0388285
CSDE1 cold shock domain containing E1, RNA-binding -0.0381021
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0380152
PFN1 profilin 1 -0.0375453
PTK2 protein tyrosine kinase 2 -0.0369575
ZBTB20 zinc finger and BTB domain containing 20 -0.0365514
CSNK1A1 casein kinase 1, alpha 1 -0.0365247
RBM25 RNA binding motif protein 25 -0.0360994
WDR43 WD repeat domain 43 -0.03535
ACTN1 actinin, alpha 1 -0.0352754
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0348783
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0347392
ATP13A3 ATPase type 13A3 -0.0343783
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0340342
EXT1 exostosin glycosyltransferase 1 -0.0334198
EGFR epidermal growth factor receptor -0.0330542
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0330159
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0328004
ANO6 anoctamin 6 -0.0325913
VMP1 vacuole membrane protein 1 -0.0322914
GSK3B glycogen synthase kinase 3 beta -0.031872
VCL vinculin -0.0317016
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0316766
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0316321
FMNL2 formin-like 2 -0.0314795
RBM39 RNA binding motif protein 39 -0.0312281
SHB Src homology 2 domain containing adaptor protein B -0.0311473
MYPN myopalladin -0.0310968
PNN pinin, desmosome associated protein -0.0310706
ELL2 elongation factor, RNA polymerase II, 2 -0.030416
BIRC6 baculoviral IAP repeat containing 6 -0.0303905
ADAM9 ADAM metallopeptidase domain 9 -0.0300881
LATS2 large tumor suppressor kinase 2 -0.0299306
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0298574
PHIP pleckstrin homology domain interacting protein -0.029819
COPA coatomer protein complex, subunit alpha -0.0296989
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0294533
JMJD1C jumonji domain containing 1C -0.029044
RUSC2 RUN and SH3 domain containing 2 -0.0289261
CCDC91 coiled-coil domain containing 91 -0.0286175
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -0.0283331
SFPQ splicing factor proline/glutamine-rich -0.0280628
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0280509
XPO6 exportin 6 -0.0279545
SNX9 sorting nexin 9 -0.0278984
NTSR1 neurotensin receptor 1 (high affinity) -0.0277374
RNF145 ring finger protein 145 -0.0273627
CDCP1 CUB domain containing protein 1 -0.0271593
TSC22D2 TSC22 domain family, member 2 -0.0266893
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.026559
STC1 stanniocalcin 1 -0.026234
USP34 ubiquitin specific peptidase 34 -0.0261957
CDYL chromodomain protein, Y-like -0.0259042
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0258366
PCNX1 pecanex 1 -0.0258101
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0257408
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L -0.0257183
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0256553
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0256296
OGT O-linked N-acetylglucosamine (GlcNAc) transferase -0.0255606
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0254129
WWTR1 WW domain containing transcription regulator 1 -0.0252137
MSN moesin -0.0251668
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0251645
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0249185
BMAL2 basic helix-loop-helix ARNT like 2 -0.0247891