9-ING-41_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 9-ING-41 perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 9-ING-41_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.299084
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.261809
FN1 fibronectin 1 0.172755
PABPC1 poly(A) binding protein, cytoplasmic 1 0.133108
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.132145
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.118753
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0789941
ALCAM activated leukocyte cell adhesion molecule 0.0780931
EEF2 eukaryotic translation elongation factor 2 0.0779464
RACK1 receptor for activated C kinase 1 0.0746857
S100A6 S100 calcium binding protein A6 0.0728247
NAMPT nicotinamide phosphoribosyltransferase 0.070977
RPLP0 ribosomal protein, large, P0 0.0698637
ACTG1 actin gamma 1 0.0694693
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0689636
UBC ubiquitin C 0.0682822
ASPH aspartate beta-hydroxylase 0.0674785
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0673638
ENO1 enolase 1, (alpha) 0.0657927
SQSTM1 sequestosome 1 0.0649628
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0609365
SLC38A1 solute carrier family 38, member 1 0.0599698
CTSB cathepsin B 0.0597634
ANXA2 annexin A2 0.0586513
TPT1 tumor protein, translationally-controlled 1 0.0567026
RPLP1 ribosomal protein, large, P1 0.0548395
TM4SF1 transmembrane 4 L six family member 1 0.0525545
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0512752
ERRFI1 ERBB receptor feedback inhibitor 1 0.0510406
FTL ferritin, light polypeptide 0.04983
RPS6 ribosomal protein S6 0.0497104
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0492497
RPL4 ribosomal protein L4 0.0476373
TXNRD1 thioredoxin reductase 1 0.0474593
BHLHE40 basic helix-loop-helix family, member e40 0.0473197
RAD21 RAD21 homolog (S. pombe) 0.0460898
TOP2A topoisomerase (DNA) II alpha 170kDa 0.044274
LAMC2 laminin, gamma 2 0.0441545
RPL23 ribosomal protein L23 0.0435383
RPL12 ribosomal protein L12 0.0428878
HMGA1 high mobility group AT-hook 1 0.0417985
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0410321
RPL34 ribosomal protein L34 0.0409752
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0403998
RPL7 ribosomal protein L7 0.0391009
RPL11 ribosomal protein L11 0.0385447
AHNAK AHNAK nucleoprotein 0.0373548
STEAP4 STEAP family member 4 0.0372669
RPS8 ribosomal protein S8 0.0371062
LDHA lactate dehydrogenase A 0.0370793
RPS24 ribosomal protein S24 0.0368423
RPS2 ribosomal protein S2 0.0361514
EIF1 eukaryotic translation initiation factor 1 0.0361165
SGMS2 sphingomyelin synthase 2 0.0358279
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0348427
DSPP dentin sialophosphoprotein 0.0345536
CANX calnexin 0.034271
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0337981
RPL8 ribosomal protein L8 0.0337558
KRT7 keratin 7, type II 0.0335895
MKI67 marker of proliferation Ki-67 0.0327981
RPS20 ribosomal protein S20 0.03272
RPL27A ribosomal protein L27a 0.0326423
FTH1 ferritin, heavy polypeptide 1 0.0322494
HMGB2 high mobility group box 2 0.0317541
LOC112694756 uncharaterized LOC112694756 0.0316151
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0314462
KIAA1217 KIAA1217 0.0313896
RPS13 ribosomal protein S13 0.0309969
RPL35A ribosomal protein L35a 0.0309748
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0309463
CCNI cyclin I 0.0300418
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0296509
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0296465
RPL37 ribosomal protein L37 0.0296048
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0294253
ARRDC3 arrestin domain containing 3 0.0290703
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0286191
RPL30 ribosomal protein L30 0.0284578
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0283808
PTMA prothymosin, alpha 0.02831
IL6ST interleukin 6 signal transducer 0.0281802
KPNB1 karyopherin (importin) beta 1 0.0281013
DSG2 desmoglein 2 0.0278338
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.027807
RPS16 ribosomal protein S16 0.0276804
ARF1 ADP-ribosylation factor 1 0.0276632
CAPN2 calpain 2, (m/II) large subunit 0.0267266
RPL15 ribosomal protein L15 0.026677
IRF6 interferon regulatory factor 6 0.0263462
RPS5 ribosomal protein S5 0.0262796
HSPA8 heat shock 70kDa protein 8 0.0260353
PGK1 phosphoglycerate kinase 1 0.0255239
RPS25 ribosomal protein S25 0.0254842
RPS27A ribosomal protein S27a 0.0254142
TUBA1B tubulin, alpha 1b 0.0253766
DSTN destrin (actin depolymerizing factor) 0.0252983
SDC4 syndecan 4 0.0250599
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0248592
RPL19 ribosomal protein L19 0.024244

decreased expression

Symbol Name Standardized Value
GRB10 growth factor receptor-bound protein 10 -0.116861
LPP LIM domain containing preferred translocation partner in lipoma -0.0870343
LIMCH1 LIM and calponin homology domains 1 -0.068194
TSC22D2 TSC22 domain family, member 2 -0.067446
PDLIM5 PDZ and LIM domain 5 -0.0480294
CTBP2 C-terminal binding protein 2 -0.047868
SAMD4A sterile alpha motif domain containing 4A -0.04718
TMSB10 thymosin beta 10 -0.0459105
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0428866
FNDC3B fibronectin type III domain containing 3B -0.0413071
MYH9 myosin, heavy chain 9, non-muscle -0.0397413
RNF213 ring finger protein 213 -0.0392769
VEGFA vascular endothelial growth factor A -0.0382532
WSB1 WD repeat and SOCS box containing 1 -0.0375304
KDM5B lysine (K)-specific demethylase 5B -0.0374209
MSI2 musashi RNA-binding protein 2 -0.0371195
EXT1 exostosin glycosyltransferase 1 -0.0364907
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0359402
BASP1 brain abundant, membrane attached signal protein 1 -0.0352219
RAI14 retinoic acid induced 14 -0.0351834
RCOR1 REST corepressor 1 -0.035138
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0347533
PTK2 protein tyrosine kinase 2 -0.0336544
STRN3 striatin, calmodulin binding protein 3 -0.0319594
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0314242
ENO2 enolase 2 (gamma, neuronal) -0.0310879
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0308589
KMT2C lysine (K)-specific methyltransferase 2C -0.030118
TMEM165 transmembrane protein 165 -0.0300186
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0290613
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0287753
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0286357
MAML2 mastermind-like 2 (Drosophila) -0.0279994
PLEC plectin -0.0279091
FLNB filamin B, beta -0.0278699
PICALM phosphatidylinositol binding clathrin assembly protein -0.0275496
ZSWIM6 zinc finger, SWIM-type containing 6 -0.027327
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0271694
MCU mitochondrial calcium uniporter -0.026951
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0260367
COPA coatomer protein complex, subunit alpha -0.0259371
PRRC2C proline-rich coiled-coil 2C -0.0258367
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0254593
ESYT2 extended synaptotagmin-like protein 2 -0.0254285
SEC23A Sec23 homolog A (S. cerevisiae) -0.0252296
EFNA5 ephrin-A5 -0.0250198
RBM25 RNA binding motif protein 25 -0.024936
CERT1 ceramide transporter 1 -0.0248902
ATP11A ATPase, class VI, type 11A -0.0248484
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0247375
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0244518
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0243279
DTNA dystrobrevin, alpha -0.0242397
ANKRD11 ankyrin repeat domain 11 -0.0237894
AKAP13 A kinase (PRKA) anchor protein 13 -0.0235031
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0233527
BIRC6 baculoviral IAP repeat containing 6 -0.0232868
CD109 CD109 molecule -0.0229853
NF1 neurofibromin 1 -0.0227711
JUP junction plakoglobin -0.0222994
FBXO34 F-box protein 34 -0.0218816
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0215643
ATOSA atos homolog A -0.0212813
RBM39 RNA binding motif protein 39 -0.020953
KLC1 kinesin light chain 1 -0.0208807
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0206143
WASF2 WAS protein family, member 2 -0.0205037
COG6 component of oligomeric golgi complex 6 -0.0201972
BRWD1 bromodomain and WD repeat domain containing 1 -0.0200604
ZFAND3 zinc finger, AN1-type domain 3 -0.0199878
MAML3 mastermind-like 3 (Drosophila) -0.0199867
USP53 ubiquitin specific peptidase 53 -0.0198025
NCOA2 nuclear receptor coactivator 2 -0.0195049
MON2 MON2 homolog (S. cerevisiae) -0.0194737
ARID4B AT rich interactive domain 4B (RBP1-like) -0.019455
RAD51B RAD51 paralog B -0.0194239
MYO1E myosin IE -0.0190649
RREB1 ras responsive element binding protein 1 -0.0189823
TMF1 TATA element modulatory factor 1 -0.0189335
UBE2H ubiquitin-conjugating enzyme E2H -0.0188732
TBC1D22A TBC1 domain family, member 22A -0.018864
ARHGAP20 Rho GTPase activating protein 20 -0.0188219
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.0188138
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 -0.0188036
RSF1 remodeling and spacing factor 1 -0.0187089
AKAP9 A kinase (PRKA) anchor protein 9 -0.0185561
OSBPL3 oxysterol binding protein-like 3 -0.0185239
KMT2E lysine (K)-specific methyltransferase 2E -0.0183931
TTC3 tetratricopeptide repeat domain 3 -0.018293
KDM4B lysine (K)-specific demethylase 4B -0.018203
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.01807
PDIA5 protein disulfide isomerase family A, member 5 -0.0180023
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0179367
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.017517
SETD5 SET domain containing 5 -0.0174475
ARF4 ADP-ribosylation factor 4 -0.0174406
SEC24D SEC24 family member D -0.0173248
ITCH itchy E3 ubiquitin protein ligase -0.0172881
MX2 MX dynamin-like GTPase 2 -0.0171813
FNIP1 folliculin interacting protein 1 -0.0167695