9-ING-41_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 9-ING-41 perturbation in NCI-H460 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the 9-ING-41_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.168457
TPT1 tumor protein, translationally-controlled 1 0.123549
RPS12 ribosomal protein S12 0.100018
VIM vimentin 0.0964894
RPS6 ribosomal protein S6 0.0866961
RPL37A ribosomal protein L37a 0.0786268
RPS8 ribosomal protein S8 0.0774059
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0765826
PDLIM5 PDZ and LIM domain 5 0.0756909
SQSTM1 sequestosome 1 0.0710248
RPS3 ribosomal protein S3 0.0691284
KYNU kynureninase 0.0684654
RPL26 ribosomal protein L26 0.0682274
COL8A1 collagen, type VIII, alpha 1 0.0628513
MAP7 microtubule-associated protein 7 0.058649
AGTPBP1 ATP/GTP binding protein 1 0.0574952
EEF2 eukaryotic translation elongation factor 2 0.0573083
FMNL2 formin-like 2 0.0540408
RPL31 ribosomal protein L31 0.0527645
RACK1 receptor for activated C kinase 1 0.052376
SMAD2 SMAD family member 2 0.0509591
CDH13 cadherin 13 0.0496733
RPS23 ribosomal protein S23 0.0485399
RPS17 ribosomal protein S17 0.0482176
SH3KBP1 SH3-domain kinase binding protein 1 0.0467389
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.045248
RPS27 ribosomal protein S27 0.0428834
RPL9 ribosomal protein L9 0.0409415
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0408493
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0407035
NTN4 netrin 4 0.0394569
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0392766
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0391752
P3H2 prolyl 3-hydroxylase 2 0.039134
RPL12 ribosomal protein L12 0.0390228
EXT1 exostosin glycosyltransferase 1 0.0385683
RPL37 ribosomal protein L37 0.0382385
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0377065
RPS2 ribosomal protein S2 0.037387
XYLT1 xylosyltransferase I 0.0372722
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0365927
FNDC3A fibronectin type III domain containing 3A 0.0360963
PM20D1 peptidase M20 domain containing 1 0.0357933
PDE4D phosphodiesterase 4D, cAMP-specific 0.0351051
COL5A2 collagen, type V, alpha 2 0.0349718
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0349055
FNIP1 folliculin interacting protein 1 0.0347085
AUTS2 autism susceptibility candidate 2 0.0335695
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0327595
RPS29 ribosomal protein S29 0.0327481
ZEB2 zinc finger E-box binding homeobox 2 0.0326072
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0317783
CUX1 cut-like homeobox 1 0.030939
RPS27A ribosomal protein S27a 0.03088
SMOC1 SPARC related modular calcium binding 1 0.0307842
RPL36A ribosomal protein L36a 0.0303801
EIF1 eukaryotic translation initiation factor 1 0.0303357
CD44 CD44 molecule (Indian blood group) 0.0302275
CLIP1 CAP-GLY domain containing linker protein 1 0.0295404
RPL34 ribosomal protein L34 0.0291158
RPL35A ribosomal protein L35a 0.0279603
OXSR1 oxidative stress responsive 1 0.027386
RPS19 ribosomal protein S19 0.027271
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0269237
RPS13 ribosomal protein S13 0.026883
RPS25 ribosomal protein S25 0.0268736
NFX1 nuclear transcription factor, X-box binding 1 0.0265016
RPL7A ribosomal protein L7a 0.025749
SFTPA2 surfactant protein A2 0.0252747
ENO1 enolase 1, (alpha) 0.0248805
RAD51B RAD51 paralog B 0.0247261
RPL19 ribosomal protein L19 0.0245967
AKAP13 A kinase (PRKA) anchor protein 13 0.0245683
ZFHX3 zinc finger homeobox 3 0.0245218
PDE1A phosphodiesterase 1A, calmodulin-dependent 0.0243115
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0242992
RPL4 ribosomal protein L4 0.0241409
LOC102724023 ES1 protein homolog, mitochondrial 0.0237243
CHL1 cell adhesion molecule L1-like 0.0235662
DNAH14 dynein, axonemal, heavy chain 14 0.0232725
RASAL2 RAS protein activator like 2 0.0232047
RPL7 ribosomal protein L7 0.0225098
ANXA2 annexin A2 0.0216892
MYPN myopalladin 0.0215843
ZSWIM6 zinc finger, SWIM-type containing 6 0.021288
RPS16 ribosomal protein S16 0.0209186
ASTN2 astrotactin 2 0.0208293
LGALS3 lectin, galactoside-binding, soluble, 3 0.020792
RPLP0 ribosomal protein, large, P0 0.0206766
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0204504
RAB31 RAB31, member RAS oncogene family 0.020383
RPL11 ribosomal protein L11 0.0202335
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0200808
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0200001
SORBS2 sorbin and SH3 domain containing 2 0.0199297
SAMD4A sterile alpha motif domain containing 4A 0.0197842
DNER delta/notch-like EGF repeat containing 0.0197255
IGF1R insulin-like growth factor 1 receptor 0.0196318
RPL36 ribosomal protein L36 0.0196069
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0194842

decreased expression

Symbol Name Standardized Value
EFNA5 ephrin-A5 -0.1217
NAMPT nicotinamide phosphoribosyltransferase -0.110328
TMSB10 thymosin beta 10 -0.0816493
TXNRD1 thioredoxin reductase 1 -0.0760175
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0738723
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0699573
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0690994
NRCAM neuronal cell adhesion molecule -0.0684277
ASPH aspartate beta-hydroxylase -0.0630724
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0555107
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0534105
GRAMD1B GRAM domain containing 1B -0.0507326
LIMCH1 LIM and calponin homology domains 1 -0.0493336
RTN4 reticulon 4 -0.0478406
TFPI2 tissue factor pathway inhibitor 2 -0.0446817
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0439789
IGFBP3 insulin-like growth factor binding protein 3 -0.042832
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0391645
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -0.0386686
PCBP3 poly(rC) binding protein 3 -0.038512
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0374926
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0374527
CENPF centromere protein F, 350/400kDa -0.0356112
ELL2 elongation factor, RNA polymerase II, 2 -0.0351676
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0351524
FTH1 ferritin, heavy polypeptide 1 -0.034832
PTMA prothymosin, alpha -0.0344909
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0327381
RBM39 RNA binding motif protein 39 -0.0326799
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0323127
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0322126
OGA O-GlcNAcase -0.0318283
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0317429
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.0308252
RGS2 regulator of G-protein signaling 2 -0.0301444
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0301408
KMT2C lysine (K)-specific methyltransferase 2C -0.0300082
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0299496
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.029654
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0292952
ATP5F1B ATP synthase F1 subunit beta -0.0292292
FN1 fibronectin 1 -0.0290855
MFF mitochondrial fission factor -0.028612
PTGR1 prostaglandin reductase 1 -0.0276495
BRWD3 bromodomain and WD repeat domain containing 3 -0.0270594
WDFY2 WD repeat and FYVE domain containing 2 -0.0270053
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0269905
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0264302
NUP58 nucleoporin 58 -0.0260816
PRRC2C proline-rich coiled-coil 2C -0.0252915
GNAS GNAS complex locus -0.0250081
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0249183
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0248547
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0247717
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0244171
MCL1 myeloid cell leukemia 1 -0.0242697
PNISR PNN-interacting serine/arginine-rich protein -0.0242328
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.024205
FNDC3B fibronectin type III domain containing 3B -0.024157
TRA2A transformer 2 alpha homolog (Drosophila) -0.0238482
ZNF292 zinc finger protein 292 -0.0238163
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0237923
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0237716
RBM25 RNA binding motif protein 25 -0.0236717
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -0.0235355
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0235312
EGR1 early growth response 1 -0.0232272
WDR45B WD repeat domain 45B -0.0232057
PDGFA platelet-derived growth factor alpha polypeptide -0.0231001
CHD1L chromodomain helicase DNA binding protein 1-like -0.022998
PCBP2 poly(rC) binding protein 2 -0.0228778
SRGN serglycin -0.0227933
FAM13A family with sequence similarity 13, member A -0.0226553
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0225835
TSC22D2 TSC22 domain family, member 2 -0.0224761
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.022406
RTN1 reticulon 1 -0.0223263
PYGL phosphorylase, glycogen, liver -0.0222366
GOLGA4 golgin A4 -0.0217991
BIRC6 baculoviral IAP repeat containing 6 -0.0217293
SLF1 SMC5-SMC6 complex localization factor 1 -0.0216862
AGFG1 ArfGAP with FG repeats 1 -0.0215906
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0215057
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0214674
NPAS2 neuronal PAS domain protein 2 -0.0214233
LAMB1 laminin, beta 1 -0.0212411
RAI1 retinoic acid induced 1 -0.0212329
TENT5A terminal nucleotidyltransferase 5A -0.0211516
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0211217
YBX1 Y box binding protein 1 -0.0211006
SPAG9 sperm associated antigen 9 -0.0206144
KMT2E lysine (K)-specific methyltransferase 2E -0.0206111
ADAM9 ADAM metallopeptidase domain 9 -0.0203857
DIAPH3 diaphanous-related formin 3 -0.0203325
PHF21A PHD finger protein 21A -0.0201209
USP3 ubiquitin specific peptidase 3 -0.0198039
COL4A6 collagen, type IV, alpha 6 -0.0197922
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.019695
NBAS neuroblastoma amplified sequence -0.0196278
CCDC88A coiled-coil domain containing 88A -0.019541