9-ING-41_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 9-ING-41 perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 9-ING-41_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
STC1 stanniocalcin 1 0.245577
CD44 CD44 molecule (Indian blood group) 0.169269
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.161212
AKAP12 A kinase (PRKA) anchor protein 12 0.143785
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.14042
TPT1 tumor protein, translationally-controlled 1 0.135909
IGF2 insulin-like growth factor 2 0.132295
NALF1 NALCN channel auxiliary factor 1 0.117256
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.113655
INHBA inhibin, beta A 0.107138
PHF14 PHD finger protein 14 0.101269
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0962948
RPL37 ribosomal protein L37 0.0859169
EGFR epidermal growth factor receptor 0.08399
VIM vimentin 0.0817675
NFE2L2 nuclear factor, erythroid 2-like 2 0.077119
ALCAM activated leukocyte cell adhesion molecule 0.0718436
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0716495
ANKRD11 ankyrin repeat domain 11 0.0706488
DGKH diacylglycerol kinase, eta 0.0704519
RAD51B RAD51 paralog B 0.0695408
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0675014
PRKCA protein kinase C, alpha 0.0672514
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0669495
FN1 fibronectin 1 0.066729
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0663686
HMGA2 high mobility group AT-hook 2 0.0648829
MACF1 microtubule-actin crosslinking factor 1 0.0640764
MYO1E myosin IE 0.0631106
TRIP12 thyroid hormone receptor interactor 12 0.0624436
CDCP1 CUB domain containing protein 1 0.0614257
PRKG1 protein kinase, cGMP-dependent, type I 0.0604711
LMO7 LIM domain 7 0.0603454
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.059723
IGF1R insulin-like growth factor 1 receptor 0.0596372
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0591576
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0585536
TRIO trio Rho guanine nucleotide exchange factor 0.0585462
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0582955
AFF4 AF4/FMR2 family, member 4 0.0578162
LOC102724023 ES1 protein homolog, mitochondrial 0.0574761
SOD2 superoxide dismutase 2, mitochondrial 0.0570626
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.055434
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0552178
ENO1 enolase 1, (alpha) 0.0550343
NKD1 naked cuticle homolog 1 (Drosophila) 0.0548002
RPLP1 ribosomal protein, large, P1 0.0516247
FOXP1 forkhead box P1 0.0512769
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0511317
ZNF638 zinc finger protein 638 0.0506122
GLIS3 GLIS family zinc finger 3 0.048872
JARID2 jumonji, AT rich interactive domain 2 0.0474118
PCBP2 poly(rC) binding protein 2 0.0472259
AHNAK AHNAK nucleoprotein 0.0467501
DSPP dentin sialophosphoprotein 0.0466882
UTRN utrophin 0.0465545
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0460039
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.045877
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0458639
CLIC4 chloride intracellular channel 4 0.0452095
SEPTIN9 septin 9 0.0445063
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0437034
FNDC3B fibronectin type III domain containing 3B 0.0420454
KMT2C lysine (K)-specific methyltransferase 2C 0.041879
NF1 neurofibromin 1 0.0411101
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0410657
RPS19 ribosomal protein S19 0.0402168
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0401227
RPL5 ribosomal protein L5 0.0399959
PRKN parkin RBR E3 ubiquitin protein ligase 0.0388614
RPS13 ribosomal protein S13 0.0386567
RSF1 remodeling and spacing factor 1 0.0385747
ATXN1 ataxin 1 0.0383705
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0376313
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0373485
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0357365
INTS6 integrator complex subunit 6 0.0351803
MYO10 myosin X 0.0342936
RPL13A ribosomal protein L13a 0.0342771
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0335999
VCL vinculin 0.0327727
MYO9A myosin IXA 0.0323965
RAB7A RAB7A, member RAS oncogene family 0.0321338
PDE8A phosphodiesterase 8A 0.0319449
HP1BP3 heterochromatin protein 1, binding protein 3 0.0313123
MT1X metallothionein 1X 0.0300636
ASPH aspartate beta-hydroxylase 0.0298303
LIMS1 LIM and senescent cell antigen-like domains 1 0.0295457
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0289857
SMYD3 SET and MYND domain containing 3 0.0285001
ITGAV integrin, alpha V 0.0283244
MED13L mediator complex subunit 13-like 0.0280416
TTC3 tetratricopeptide repeat domain 3 0.0274903
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 0.0270373
ATP13A3 ATPase type 13A3 0.025535
RPS3 ribosomal protein S3 0.0249003
GOLGB1 golgin B1 0.0244832
CSNK1A1 casein kinase 1, alpha 1 0.0241613
RPL34 ribosomal protein L34 0.023978
SETD2 SET domain containing 2 0.0227873

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.150731
PTMA prothymosin, alpha -0.14492
PDE10A phosphodiesterase 10A -0.13767
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.125115
GPC6 glypican 6 -0.117913
FTL ferritin, light polypeptide -0.101042
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0976201
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0864365
ARB2A ARB2 cotranscriptional regulator A -0.0859559
NCOA3 nuclear receptor coactivator 3 -0.0834523
WSB1 WD repeat and SOCS box containing 1 -0.0828538
PDE4D phosphodiesterase 4D, cAMP-specific -0.0808138
IGFBP3 insulin-like growth factor binding protein 3 -0.0743579
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0723329
FAM13A family with sequence similarity 13, member A -0.0707628
FTH1 ferritin, heavy polypeptide 1 -0.0705585
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0684217
AKAP9 A kinase (PRKA) anchor protein 9 -0.0676956
H3-3B H3.3 histone B -0.0657211
HOOK2 hook microtubule-tethering protein 2 -0.064709
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0641199
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0631685
POTEF POTE ankyrin domain family, member F -0.0626445
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0622821
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0609253
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0607039
DST dystonin -0.0593992
NAV2 neuron navigator 2 -0.0576898
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0568818
MARCHF6 membrane associated ring-CH-type finger 6 -0.0565046
RPL35A ribosomal protein L35a -0.0561361
NAMPT nicotinamide phosphoribosyltransferase -0.055307
RRAS2 related RAS viral (r-ras) oncogene homolog 2 -0.0552588
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.052714
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0524671
MATR3 matrin 3 -0.0514632
CAMTA1 calmodulin binding transcription activator 1 -0.051129
RPL19 ribosomal protein L19 -0.049807
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0497536
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0496587
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0495891
NCOR1 nuclear receptor corepressor 1 -0.0488761
ELL2 elongation factor, RNA polymerase II, 2 -0.0485112
JMJD1C jumonji domain containing 1C -0.0453944
SRRM2 serine/arginine repetitive matrix 2 -0.0452684
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0448073
EXT1 exostosin glycosyltransferase 1 -0.0437697
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0436755
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.043336
EIF1 eukaryotic translation initiation factor 1 -0.0433154
S100A10 S100 calcium binding protein A10 -0.0432624
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0430796
HDAC9 histone deacetylase 9 -0.0429102
WAC WW domain containing adaptor with coiled-coil -0.0426534
SCFD1 sec1 family domain containing 1 -0.0426254
ACTG1 actin gamma 1 -0.0416191
HELZ helicase with zinc finger -0.0414795
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0404094
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0398604
UBAP2 ubiquitin associated protein 2 -0.0397761
RPS14 ribosomal protein S14 -0.0396906
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0396241
NAP1L1 nucleosome assembly protein 1-like 1 -0.0394615
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0391923
FBXO11 F-box protein 11 -0.0386448
P4HB prolyl 4-hydroxylase, beta polypeptide -0.038634
VMP1 vacuole membrane protein 1 -0.0381144
NUP58 nucleoporin 58 -0.037981
PDIA3 protein disulfide isomerase family A, member 3 -0.037451
PHIP pleckstrin homology domain interacting protein -0.0363944
RPS11 ribosomal protein S11 -0.0356469
EEF2 eukaryotic translation elongation factor 2 -0.0355287
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0352601
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0348414
USP3 ubiquitin specific peptidase 3 -0.0347067
RAI14 retinoic acid induced 14 -0.0342073
TPM4 tropomyosin 4 -0.0333238
HLA-B major histocompatibility complex, class I, B -0.0331083
CTBP2 C-terminal binding protein 2 -0.0321761
SBF2 SET binding factor 2 -0.0318311
ZNF292 zinc finger protein 292 -0.0311985
NDRG1 N-myc downstream regulated 1 -0.0303745
DSCAM Down syndrome cell adhesion molecule -0.0296258
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0295516
RORA RAR-related orphan receptor A -0.0291049
GOLGA4 golgin A4 -0.028846
PSD3 pleckstrin and Sec7 domain containing 3 -0.0276302
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) -0.0258239
BIRC6 baculoviral IAP repeat containing 6 -0.0256096
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0255527
PGK1 phosphoglycerate kinase 1 -0.025141
OGA O-GlcNAcase -0.0251022
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0248881
CCNI cyclin I -0.0247222
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0246661
NACA nascent polypeptide-associated complex alpha subunit -0.0243246
RBM39 RNA binding motif protein 39 -0.0242447
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0237551
TPR translocated promoter region, nuclear basket protein -0.0236848
FNDC3A fibronectin type III domain containing 3A -0.0235869