9-ING-41_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 9-ING-41 perturbation in NCI-H661 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the 9-ING-41_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL11A1 collagen, type XI, alpha 1 0.168037
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.130709
PCLO piccolo presynaptic cytomatrix protein 0.11064
RPS12 ribosomal protein S12 0.0969197
CADM2 cell adhesion molecule 2 0.0930785
TPT1 tumor protein, translationally-controlled 1 0.0764453
RPS16 ribosomal protein S16 0.07251
RPS8 ribosomal protein S8 0.0705622
RPL23 ribosomal protein L23 0.0686162
RPS2 ribosomal protein S2 0.0629433
ISG15 ISG15 ubiquitin-like modifier 0.059125
EIF1 eukaryotic translation initiation factor 1 0.0578352
RPL37A ribosomal protein L37a 0.0550049
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.054779
PARD3B par-3 family cell polarity regulator beta 0.0535452
CDH19 cadherin 19, type 2 0.0535363
RPL37 ribosomal protein L37 0.0534125
COL3A1 collagen, type III, alpha 1 0.0517217
FOXP2 forkhead box P2 0.0498639
RPS6 ribosomal protein S6 0.0495656
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0485749
RPLP1 ribosomal protein, large, P1 0.0452665
RPS3 ribosomal protein S3 0.0439908
RPS17 ribosomal protein S17 0.0435811
RPS25 ribosomal protein S25 0.0413264
RPL35A ribosomal protein L35a 0.0410979
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0410458
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.0400589
HDAC9 histone deacetylase 9 0.0396751
RIMS2 regulating synaptic membrane exocytosis 2 0.0393131
B2M beta-2-microglobulin 0.0390125
TENM3 teneurin transmembrane protein 3 0.0386075
RACK1 receptor for activated C kinase 1 0.0383859
RPL26 ribosomal protein L26 0.0382757
SMYD3 SET and MYND domain containing 3 0.0376836
ITGAV integrin, alpha V 0.0375858
ACTG1 actin gamma 1 0.0368835
SQSTM1 sequestosome 1 0.0368234
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.036805
RPL31 ribosomal protein L31 0.0365831
RPS23 ribosomal protein S23 0.0364552
EEF2 eukaryotic translation elongation factor 2 0.0360976
RPS29 ribosomal protein S29 0.0359856
SAMD4A sterile alpha motif domain containing 4A 0.0355791
FTL ferritin, light polypeptide 0.0345807
VIM vimentin 0.0340686
IGF2 insulin-like growth factor 2 0.0339789
SLIT2 slit homolog 2 (Drosophila) 0.0337826
ANKRD33B ankyrin repeat domain 33B 0.0336709
RPS27 ribosomal protein S27 0.0330884
ENO1 enolase 1, (alpha) 0.0326337
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0322068
RPS27A ribosomal protein S27a 0.0321768
RPS19 ribosomal protein S19 0.031652
GREB1L growth regulation by estrogen in breast cancer-like 0.0313723
NR2F1 nuclear receptor subfamily 2, group F, member 1 0.0311146
HSPB1 heat shock 27kDa protein 1 0.0306084
DOCK5 dedicator of cytokinesis 5 0.0301906
BRD2 bromodomain containing 2 0.0300217
MCL1 myeloid cell leukemia 1 0.0299214
RPL5 ribosomal protein L5 0.0298747
USP34 ubiquitin specific peptidase 34 0.0297037
RPL36 ribosomal protein L36 0.0293676
RPS15 ribosomal protein S15 0.0290467
AKAP9 A kinase (PRKA) anchor protein 9 0.0290006
ANKRD12 ankyrin repeat domain 12 0.028927
INTS6 integrator complex subunit 6 0.0289259
CSRNP3 cysteine-serine-rich nuclear protein 3 0.0286915
MEIS2 Meis homeobox 2 0.0285427
RPL36A ribosomal protein L36a 0.0285397
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0279746
EXOC6B exocyst complex component 6B 0.027792
ARB2A ARB2 cotranscriptional regulator A 0.0273519
PKM pyruvate kinase, muscle 0.0273007
ATF4 activating transcription factor 4 0.0271958
RPL9 ribosomal protein L9 0.027167
RPS5 ribosomal protein S5 0.026928
UBN2 ubinuclein 2 0.0268806
RPL12 ribosomal protein L12 0.0268261
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0263536
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 0.026351
ARRDC3 arrestin domain containing 3 0.0261319
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.0260225
SNX6 sorting nexin 6 0.0259796
GARRE1 granule associated Rac and RHOG effector 1 0.0258407
LRMDA leucine rich melanocyte differentiation associated 0.0256427
SFTPA2 surfactant protein A2 0.0256059
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0255517
CSNK1A1 casein kinase 1, alpha 1 0.0254818
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0254339
DDIT4 DNA-damage-inducible transcript 4 0.0253111
UPP1 uridine phosphorylase 1 0.0251465
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0250847
NACA nascent polypeptide-associated complex alpha subunit 0.0249731
NCOA1 nuclear receptor coactivator 1 0.0243964
LOC102724023 ES1 protein homolog, mitochondrial 0.0240403
ZNF638 zinc finger protein 638 0.0239135
WNK1 WNK lysine deficient protein kinase 1 0.0239029
RPS13 ribosomal protein S13 0.0238607
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0238414

decreased expression

Symbol Name Standardized Value
TSC22D2 TSC22 domain family, member 2 -0.0809027
PGAP1 post-GPI attachment to proteins 1 -0.0724756
ADAM9 ADAM metallopeptidase domain 9 -0.0703926
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0699042
PEG10 paternally expressed 10 -0.0696709
TRIO trio Rho guanine nucleotide exchange factor -0.0692452
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0654228
ZNF292 zinc finger protein 292 -0.0623031
ATP5F1B ATP synthase F1 subunit beta -0.0568467
THBS1 thrombospondin 1 -0.0560786
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0552486
QKI QKI, KH domain containing, RNA binding -0.0533216
TMSB4X thymosin beta 4, X-linked -0.0521733
PFN1 profilin 1 -0.0486423
NOP58 NOP58 ribonucleoprotein -0.0461451
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0453878
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.044416
USP3 ubiquitin specific peptidase 3 -0.043879
NRG1 neuregulin 1 -0.0419571
MATR3 matrin 3 -0.0401341
PUM1 pumilio RNA-binding family member 1 -0.0384836
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0354114
LHFPL6 LHFPL tetraspan subfamily member 6 -0.0352402
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0349006
H1-0 H1.0 linker histone -0.0348913
WDR43 WD repeat domain 43 -0.0348156
STRN3 striatin, calmodulin binding protein 3 -0.0345432
EMP1 epithelial membrane protein 1 -0.0343142
IGF1R insulin-like growth factor 1 receptor -0.0342935
APP amyloid beta (A4) precursor protein -0.0333482
ZFAND3 zinc finger, AN1-type domain 3 -0.032947
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0327423
CENPF centromere protein F, 350/400kDa -0.0325904
YBX1 Y box binding protein 1 -0.0325378
MARCHF6 membrane associated ring-CH-type finger 6 -0.0321515
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0321401
PDS5B PDS5 cohesin associated factor B -0.0321038
POTEF POTE ankyrin domain family, member F -0.031898
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0315412
URI1 URI1, prefoldin-like chaperone -0.0312817
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0308652
MTF2 metal response element binding transcription factor 2 -0.0305297
RTN4 reticulon 4 -0.0305081
ZC3H15 zinc finger CCCH-type containing 15 -0.0303784
SMG7 SMG7 nonsense mediated mRNA decay factor -0.0303405
RAD21 RAD21 homolog (S. pombe) -0.0300964
NDFIP1 Nedd4 family interacting protein 1 -0.0300381
PLPP1 phospholipid phosphatase 1 -0.0293102
MRPS30 mitochondrial ribosomal protein S30 -0.0285633
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0282203
FUBP1 far upstream element (FUSE) binding protein 1 -0.0279602
PCBP2 poly(rC) binding protein 2 -0.0278829
PNISR PNN-interacting serine/arginine-rich protein -0.0278418
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0277642
ZNF217 zinc finger protein 217 -0.0274823
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0274762
CDC73 cell division cycle 73 -0.0273882
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -0.027274
VGLL3 vestigial-like family member 3 -0.0271678
CXADR coxsackie virus and adenovirus receptor -0.0267539
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0266858
HMGB1 high mobility group box 1 -0.0266216
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0264472
BCLAF1 BCL2-associated transcription factor 1 -0.026394
TCEA1 transcription elongation factor A (SII), 1 -0.0263776
RNF145 ring finger protein 145 -0.0262722
FIP1L1 factor interacting with PAPOLA and CPSF1 -0.0260927
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0256937
TRA2A transformer 2 alpha homolog (Drosophila) -0.0256762
SFRP4 secreted frizzled-related protein 4 -0.0249676
SPAG9 sperm associated antigen 9 -0.0246401
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0239323
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0238119
KMT2C lysine (K)-specific methyltransferase 2C -0.0237437
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 -0.023548
CPA6 carboxypeptidase A6 -0.0232847
H2AZ2 H2A.Z variant histone 2 -0.0232823
NPR2 natriuretic peptide receptor 2 -0.0232162
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0231954
RLF rearranged L-myc fusion -0.0229455
ORC4 origin recognition complex, subunit 4 -0.0227518
RNASE3 ribonuclease, RNase A family, 3 -0.0225467
RHOH ras homolog family member H -0.0223396
RAD23B RAD23 homolog B (S. cerevisiae) -0.0221767
GRM1 glutamate receptor, metabotropic 1 -0.0221373
SETD5 SET domain containing 5 -0.0220473
KMT2E lysine (K)-specific methyltransferase 2E -0.02189
CRY1 cryptochrome circadian clock 1 -0.0218208
ZEB2 zinc finger E-box binding homeobox 2 -0.0217032
CENPE centromere protein E, 312kDa -0.0216182
NOLC1 nucleolar and coiled-body phosphoprotein 1 -0.0211904
FBXO11 F-box protein 11 -0.0210092
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -0.0209992
ENAH enabled homolog (Drosophila) -0.0209253
RHEB Ras homolog enriched in brain -0.0207162
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0206808
DSTN destrin (actin depolymerizing factor) -0.0206441
SMAP1 small ArfGAP 1 -0.0205508
SKIC3 SKI3 subunit of superkiller complex -0.0204476
GRB2 growth factor receptor-bound protein 2 -0.0203774