9-ING-41_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 9-ING-41 perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 9-ING-41_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS16 ribosomal protein S16 0.180191
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0668049
RPS12 ribosomal protein S12 0.0550942
EIF1 eukaryotic translation initiation factor 1 0.0519691
SFTPA2 surfactant protein A2 0.0506197
TXNRD1 thioredoxin reductase 1 0.0446384
JMJD1C jumonji domain containing 1C 0.0439912
EEF2 eukaryotic translation elongation factor 2 0.0431241
RPS3 ribosomal protein S3 0.0423796
RPS8 ribosomal protein S8 0.0404272
ANXA2 annexin A2 0.0399562
DSCAM Down syndrome cell adhesion molecule 0.0398402
VCL vinculin 0.0394888
MT2A metallothionein 2A 0.0380948
RPS2 ribosomal protein S2 0.0367641
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0347997
SAMD4B sterile alpha motif domain containing 4B 0.0328865
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0313368
ACTG1 actin gamma 1 0.031212
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0307528
OGA O-GlcNAcase 0.0304431
SQSTM1 sequestosome 1 0.0299104
B2M beta-2-microglobulin 0.0289521
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0284143
TPT1 tumor protein, translationally-controlled 1 0.0283557
RPL12 ribosomal protein L12 0.0283024
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0281474
ITGAV integrin, alpha V 0.0275192
RPL26 ribosomal protein L26 0.0275071
NFE2L2 nuclear factor, erythroid 2-like 2 0.0271008
RPLP2 ribosomal protein, large, P2 0.026495
RPS17 ribosomal protein S17 0.0264095
MKI67 marker of proliferation Ki-67 0.0255052
RPL37A ribosomal protein L37a 0.0247218
RPL4 ribosomal protein L4 0.0245394
ATF6 activating transcription factor 6 0.0241821
SMYD3 SET and MYND domain containing 3 0.023508
ARRDC3 arrestin domain containing 3 0.023275
LOC102724023 ES1 protein homolog, mitochondrial 0.0231653
SIK3 SIK family kinase 3 0.0230133
RPL11 ribosomal protein L11 0.0228644
RPL7 ribosomal protein L7 0.0218589
JAK1 Janus kinase 1 0.0213764
ENO1 enolase 1, (alpha) 0.0210296
VMP1 vacuole membrane protein 1 0.0209366
RPS5 ribosomal protein S5 0.0206761
RPL23 ribosomal protein L23 0.0205719
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0205306
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0204164
RPLP0 ribosomal protein, large, P0 0.0202946
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0202411
RPS25 ribosomal protein S25 0.0200832
RPS6 ribosomal protein S6 0.0200339
BIRC2 baculoviral IAP repeat containing 2 0.0199589
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.0199185
RPL37 ribosomal protein L37 0.0198658
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0191833
ARHGAP29 Rho GTPase activating protein 29 0.019071
NAP1L1 nucleosome assembly protein 1-like 1 0.0189793
MLF1 myeloid leukemia factor 1 0.0189238
MED13L mediator complex subunit 13-like 0.0188237
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0187922
CSNK1A1 casein kinase 1, alpha 1 0.0184169
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0183393
RHOBTB3 Rho-related BTB domain containing 3 0.0182702
ACTN4 actinin, alpha 4 0.0181788
SERINC1 serine incorporator 1 0.0179466
RPL35A ribosomal protein L35a 0.0176765
IPO7 importin 7 0.0176592
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0175885
RPL34 ribosomal protein L34 0.0175818
DPY19L1 dpy-19-like 1 (C. elegans) 0.0174756
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0173784
MED13 mediator complex subunit 13 0.0173639
RPL31 ribosomal protein L31 0.0172462
RACK1 receptor for activated C kinase 1 0.0170255
CDK13 cyclin-dependent kinase 13 0.0163938
ZSWIM6 zinc finger, SWIM-type containing 6 0.0162857
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0162348
RAB10 RAB10, member RAS oncogene family 0.0161711
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.015983
RPL36A ribosomal protein L36a 0.0159826
ARB2A ARB2 cotranscriptional regulator A 0.0159268
NFE2L1 nuclear factor, erythroid 2-like 1 0.0156426
MRTFA myocardin related transcription factor A 0.0155431
RPLP1 ribosomal protein, large, P1 0.0154901
BPTF bromodomain PHD finger transcription factor 0.0152644
NUP98 nucleoporin 98kDa 0.015118
SET SET nuclear proto-oncogene 0.0151025
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0150581
EIF4A2 eukaryotic translation initiation factor 4A2 0.0150109
NAMPT nicotinamide phosphoribosyltransferase 0.0148465
ERBIN erbb2 interacting protein 0.014839
RPL28 ribosomal protein L28 0.0147222
ZBTB20 zinc finger and BTB domain containing 20 0.0146666
NCKAP1 NCK-associated protein 1 0.0146514
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0144592
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.0144203
PUM2 pumilio RNA-binding family member 2 0.0142973
TARS1 threonyl-tRNA synthetase 1 0.014202

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.477194
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.199564
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.189101
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.177638
VIM vimentin -0.128353
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.107831
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.10463
PTMA prothymosin, alpha -0.103466
THSD4 thrombospondin, type I, domain containing 4 -0.0790457
TRIO trio Rho guanine nucleotide exchange factor -0.0752635
HSPG2 heparan sulfate proteoglycan 2 -0.0729673
EGFR epidermal growth factor receptor -0.0721156
SLC35F3 solute carrier family 35, member F3 -0.0704022
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0641827
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0631281
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0617303
TMSB10 thymosin beta 10 -0.0600359
MAP1B microtubule-associated protein 1B -0.0552637
PKM pyruvate kinase, muscle -0.0510738
RNF220 ring finger protein 220 -0.0492345
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0489559
EGR1 early growth response 1 -0.04871
LDHA lactate dehydrogenase A -0.0482348
MACF1 microtubule-actin crosslinking factor 1 -0.046485
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0464817
AHNAK AHNAK nucleoprotein -0.0439444
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0435984
CTSD cathepsin D -0.0427761
FBL fibrillarin -0.0424214
MCL1 myeloid cell leukemia 1 -0.0416207
AKT2 v-akt murine thymoma viral oncogene homolog 2 -0.0408519
SEPTIN9 septin 9 -0.040732
NPAS2 neuronal PAS domain protein 2 -0.0399246
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0397376
DST dystonin -0.0392764
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0392499
NAV2 neuron navigator 2 -0.0388229
CANX calnexin -0.0382205
PDIA3 protein disulfide isomerase family A, member 3 -0.0372298
NHSL1 NHS-like 1 -0.0368031
HMGA2 high mobility group AT-hook 2 -0.0359654
FOSL1 FOS-like antigen 1 -0.0349288
MYOF myoferlin -0.0344699
MYO10 myosin X -0.034289
CD109 CD109 molecule -0.0325805
ATG7 autophagy related 7 -0.0324751
HMGA1 high mobility group AT-hook 1 -0.0323056
HYOU1 hypoxia up-regulated 1 -0.0321853
FMNL2 formin-like 2 -0.0321124
PFN1 profilin 1 -0.0319956
PDE10A phosphodiesterase 10A -0.0318806
L1CAM L1 cell adhesion molecule -0.0318677
CALR calreticulin -0.0315595
PTK2 protein tyrosine kinase 2 -0.0310885
TNS3 tensin 3 -0.0310102
CMIP c-Maf inducing protein -0.0309874
COL18A1 collagen, type XVIII, alpha 1 -0.030952
AFAP1 actin filament associated protein 1 -0.0306119
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0305569
SDK1 sidekick cell adhesion molecule 1 -0.0297827
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0297784
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0292975
CD44 CD44 molecule (Indian blood group) -0.028997
HIPK2 homeodomain interacting protein kinase 2 -0.0288555
CTBP2 C-terminal binding protein 2 -0.0287734
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0282958
FNDC3B fibronectin type III domain containing 3B -0.0282563
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0277367
KRT18 keratin 18, type I -0.0276018
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.02739
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0271549
CDCP1 CUB domain containing protein 1 -0.0269743
VEGFA vascular endothelial growth factor A -0.0265119
LOC112694756 uncharaterized LOC112694756 -0.0258249
PPARG peroxisome proliferator-activated receptor gamma -0.0253293
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0251739
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0250812
TMEM123 transmembrane protein 123 -0.0248034
UBASH3B ubiquitin associated and SH3 domain containing B -0.0246823
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.0232753
KRT19 keratin 19, type I -0.0222743
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0220067
NCOR2 nuclear receptor corepressor 2 -0.0219021
MSN moesin -0.0217831
MEF2A myocyte enhancer factor 2A -0.0216705
ZMYND8 zinc finger, MYND-type containing 8 -0.0216019
EHBP1 EH domain binding protein 1 -0.0214649
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0214242
DIAPH2 diaphanous-related formin 2 -0.0209799
MYH9 myosin, heavy chain 9, non-muscle -0.0208271
HPCAL1 hippocalcin-like 1 -0.0207323
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0207134
ATM ATM serine/threonine kinase -0.0207117
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0204374
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0204004
POTEF POTE ankyrin domain family, member F -0.0203199
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0202806
TPM1 tropomyosin 1 (alpha) -0.0200964
HM13 histocompatibility (minor) 13 -0.019992
GRK5 G protein-coupled receptor kinase 5 -0.0199608