9-ING-41_RPMI-7951 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 9-ING-41 perturbation in RPMI-7951 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 9-ING-41_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
STC1 stanniocalcin 1 0.224365
B2M beta-2-microglobulin 0.0956525
VIM vimentin 0.0834391
FTL ferritin, light polypeptide 0.0827167
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0824615
TFPI2 tissue factor pathway inhibitor 2 0.0449549
IFI6 interferon, alpha-inducible protein 6 0.0422971
MT2A metallothionein 2A 0.0418076
RPS6 ribosomal protein S6 0.0400389
CEMIP cell migration inducing protein, hyaluronan binding 0.0381165
RND3 Rho family GTPase 3 0.0377746
EEF2 eukaryotic translation elongation factor 2 0.0370128
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0347795
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0314493
IFIH1 interferon induced with helicase C domain 1 0.0286834
NAV2 neuron navigator 2 0.0285953
TPT1 tumor protein, translationally-controlled 1 0.027157
SOD2 superoxide dismutase 2, mitochondrial 0.0261484
RPS8 ribosomal protein S8 0.0256167
PMP22 peripheral myelin protein 22 0.0247382
ANKRD28 ankyrin repeat domain 28 0.0244155
PTMA prothymosin, alpha 0.0241717
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0239599
RAB7A RAB7A, member RAS oncogene family 0.0236291
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.0234831
RPL12 ribosomal protein L12 0.023326
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.022165
OSBPL8 oxysterol binding protein-like 8 0.0220042
UBC ubiquitin C 0.0218628
IFI16 interferon, gamma-inducible protein 16 0.0216414
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0216382
CTSB cathepsin B 0.0216233
SQSTM1 sequestosome 1 0.0213757
NAMPT nicotinamide phosphoribosyltransferase 0.0211612
KYNU kynureninase 0.0210253
RPL11 ribosomal protein L11 0.0210007
ESYT2 extended synaptotagmin-like protein 2 0.0207084
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0207011
HLA-B major histocompatibility complex, class I, B 0.0197823
ENO1 enolase 1, (alpha) 0.0196159
RPL23 ribosomal protein L23 0.019515
HDAC9 histone deacetylase 9 0.0194984
RB1CC1 RB1-inducible coiled-coil 1 0.019327
GOLGA4 golgin A4 0.0193255
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0190945
CREBRF CREB3 regulatory factor 0.0190277
BPTF bromodomain PHD finger transcription factor 0.0188934
HLA-E major histocompatibility complex, class I, E 0.0186647
IL6ST interleukin 6 signal transducer 0.0185527
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0182969
KLHL24 kelch-like family member 24 0.0182247
RPLP1 ribosomal protein, large, P1 0.0180857
ARL4C ADP-ribosylation factor-like 4C 0.018008
NAP1L1 nucleosome assembly protein 1-like 1 0.0177496
RPS27A ribosomal protein S27a 0.0176198
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0173353
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0171617
RPL7 ribosomal protein L7 0.0170757
RPS25 ribosomal protein S25 0.0167978
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0163353
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0163107
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0161052
RPS16 ribosomal protein S16 0.0156876
RPS27 ribosomal protein S27 0.0156143
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0155896
CDCP1 CUB domain containing protein 1 0.0155432
FNIP1 folliculin interacting protein 1 0.0154432
RPL31 ribosomal protein L31 0.0154226
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0152515
RPLP2 ribosomal protein, large, P2 0.0152301
RPL37 ribosomal protein L37 0.015207
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 0.0151661
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0151623
RPL15 ribosomal protein L15 0.015124
SFTPA2 surfactant protein A2 0.0151177
RPL34 ribosomal protein L34 0.015105
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0150313
RPS13 ribosomal protein S13 0.0148464
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0148275
CENPF centromere protein F, 350/400kDa 0.0147783
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0145961
RPS20 ribosomal protein S20 0.0145566
ANXA2 annexin A2 0.0145069
FTH1 ferritin, heavy polypeptide 1 0.014498
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0143663
EIF1 eukaryotic translation initiation factor 1 0.0138878
NIPBL Nipped-B homolog (Drosophila) 0.0137848
SP100 SP100 nuclear antigen 0.0137183
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0136217
LAMP2 lysosomal-associated membrane protein 2 0.0136181
RPL5 ribosomal protein L5 0.0135147
BHLHE40 basic helix-loop-helix family, member e40 0.0135123
NCKAP1 NCK-associated protein 1 0.0133672
KIF5B kinesin family member 5B 0.0133093
RPL4 ribosomal protein L4 0.0131147
PNRC1 proline-rich nuclear receptor coactivator 1 0.0130532
RPS24 ribosomal protein S24 0.0130246
RPLP0 ribosomal protein, large, P0 0.0130236
S100A9 S100 calcium binding protein A9 0.0129953
S100A6 S100 calcium binding protein A6 0.0129776

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.497032
PSD3 pleckstrin and Sec7 domain containing 3 -0.174969
TIMP3 TIMP metallopeptidase inhibitor 3 -0.130957
COL5A1 collagen, type V, alpha 1 -0.125677
FRMD4A FERM domain containing 4A -0.106236
COL1A1 collagen, type I, alpha 1 -0.102568
NDRG1 N-myc downstream regulated 1 -0.0947461
CDH13 cadherin 13 -0.0933199
TMEM178B transmembrane protein 178B -0.0931787
COL6A1 collagen, type VI, alpha 1 -0.0925016
FNDC3B fibronectin type III domain containing 3B -0.0897412
COL1A2 collagen, type I, alpha 2 -0.0851378
NAV1 neuron navigator 1 -0.0802635
COL7A1 collagen, type VII, alpha 1 -0.07546
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0682678
COL6A2 collagen, type VI, alpha 2 -0.0681267
ZEB1 zinc finger E-box binding homeobox 1 -0.0680959
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.066127
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0644844
EGR1 early growth response 1 -0.0644142
PDE4D phosphodiesterase 4D, cAMP-specific -0.0627718
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0619763
TPM1 tropomyosin 1 (alpha) -0.0615028
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0596194
FAM20C family with sequence similarity 20, member C -0.0573375
ASPH aspartate beta-hydroxylase -0.0567203
LOXL2 lysyl oxidase-like 2 -0.0564385
GLIS3 GLIS family zinc finger 3 -0.0538013
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0523903
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0505939
NPAS2 neuronal PAS domain protein 2 -0.0502966
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0495621
GRB10 growth factor receptor-bound protein 10 -0.0484603
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0481087
TNNC1 troponin C type 1 (slow) -0.048016
MYH9 myosin, heavy chain 9, non-muscle -0.0479473
IGFBP3 insulin-like growth factor binding protein 3 -0.0459339
MAML3 mastermind-like 3 (Drosophila) -0.0458412
MAML2 mastermind-like 2 (Drosophila) -0.0434665
VEGFA vascular endothelial growth factor A -0.0434253
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.043115
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0411019
EGFR epidermal growth factor receptor -0.0404003
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0402241
RRBP1 ribosome binding protein 1 -0.0393971
PDLIM5 PDZ and LIM domain 5 -0.0389261
VCL vinculin -0.0385087
TENT5A terminal nucleotidyltransferase 5A -0.0380408
POTEF POTE ankyrin domain family, member F -0.0378332
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0373093
PCBP3 poly(rC) binding protein 3 -0.0369591
TNS3 tensin 3 -0.036838
SH3RF3 SH3 domain containing ring finger 3 -0.0367822
IGFBP5 insulin-like growth factor binding protein 5 -0.0367574
ATXN1 ataxin 1 -0.036653
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0359192
ZBTB20 zinc finger and BTB domain containing 20 -0.035711
NREP neuronal regeneration related protein -0.035528
FBN1 fibrillin 1 -0.0352959
APCDD1L adenomatosis polyposis coli down-regulated 1-like -0.0347205
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0345764
SLIT2 slit homolog 2 (Drosophila) -0.0341941
ADAM12 ADAM metallopeptidase domain 12 -0.0338917
EXT1 exostosin glycosyltransferase 1 -0.0338696
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0331709
INTS6 integrator complex subunit 6 -0.0318803
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0317767
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0310034
THBS1 thrombospondin 1 -0.0307705
LPP LIM domain containing preferred translocation partner in lipoma -0.0307583
PTPRG protein tyrosine phosphatase, receptor type, G -0.0306491
FLNB filamin B, beta -0.0306074
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0299482
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) -0.0299406
TWIST2 twist family bHLH transcription factor 2 -0.0298067
ITGA1 integrin, alpha 1 -0.029537
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0290904
DLG1 discs, large homolog 1 (Drosophila) -0.0289778
MSN moesin -0.028584
INHBA inhibin, beta A -0.0280308
CADM1 cell adhesion molecule 1 -0.0278724
ACTN1 actinin, alpha 1 -0.0277081
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0276916
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0276302
PKM pyruvate kinase, muscle -0.0275517
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0275492
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0272585
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0272013
COL5A2 collagen, type V, alpha 2 -0.0271375
EML5 echinoderm microtubule associated protein like 5 -0.0270496
KCNMB3 potassium channel subfamily M regulatory beta subunit 3 -0.0265712
SHISA5 shisa family member 5 -0.0265421
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0258168
COL4A2 collagen, type IV, alpha 2 -0.0257537
MTSS1 metastasis suppressor 1 -0.0256089
MAP1B microtubule-associated protein 1B -0.0252925
RUNX1 runt-related transcription factor 1 -0.0252142
ZFAND3 zinc finger, AN1-type domain 3 -0.025167
CAPZB capping protein (actin filament) muscle Z-line, beta -0.0249008
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -0.0248275