9-ING-41_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 9-ING-41 perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 9-ING-41_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.116516
RPS6 ribosomal protein S6 0.102463
RPL37A ribosomal protein L37a 0.0837309
RPS3 ribosomal protein S3 0.0751364
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0750205
STC1 stanniocalcin 1 0.0701268
RPS8 ribosomal protein S8 0.069175
CALCA calcitonin-related polypeptide alpha 0.0690266
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0595073
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0574956
RPL7 ribosomal protein L7 0.0566316
RPL26 ribosomal protein L26 0.055224
RPS12 ribosomal protein S12 0.0548986
RPL37 ribosomal protein L37 0.0548836
ACTG1 actin gamma 1 0.0546951
RPL11 ribosomal protein L11 0.0537326
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.049166
FTL ferritin, light polypeptide 0.0489588
RPS27 ribosomal protein S27 0.0489498
RPL12 ribosomal protein L12 0.0459139
RPL8 ribosomal protein L8 0.0447897
RPS19 ribosomal protein S19 0.0434157
IFI6 interferon, alpha-inducible protein 6 0.0411339
RPL36 ribosomal protein L36 0.0409784
RPL32 ribosomal protein L32 0.0409081
RPS16 ribosomal protein S16 0.0398527
RPL31 ribosomal protein L31 0.0397503
RPL19 ribosomal protein L19 0.0396151
MAP1B microtubule-associated protein 1B 0.0394527
EIF1 eukaryotic translation initiation factor 1 0.0389406
SNAP25 synaptosomal-associated protein, 25kDa 0.0388862
CPE carboxypeptidase E 0.0378711
RPS29 ribosomal protein S29 0.0375835
RACK1 receptor for activated C kinase 1 0.0373834
RPS17 ribosomal protein S17 0.0372044
B2M beta-2-microglobulin 0.0367624
RPS2 ribosomal protein S2 0.0361677
RPS25 ribosomal protein S25 0.0354358
MT2A metallothionein 2A 0.0347376
RPS21 ribosomal protein S21 0.0345409
NBEA neurobeachin 0.0344676
TPT1 tumor protein, translationally-controlled 1 0.0336648
RPS23 ribosomal protein S23 0.0334057
INHBA inhibin, beta A 0.0332105
ISG15 ISG15 ubiquitin-like modifier 0.0324963
RPLP1 ribosomal protein, large, P1 0.0324315
RPS11 ribosomal protein S11 0.0320937
RPL35 ribosomal protein L35 0.0318848
FNDC3A fibronectin type III domain containing 3A 0.0317035
DSTN destrin (actin depolymerizing factor) 0.0315424
RPS15 ribosomal protein S15 0.0314705
RPL35A ribosomal protein L35a 0.0312242
RPS5 ribosomal protein S5 0.0308911
RPL18 ribosomal protein L18 0.0292002
SIK2 salt-inducible kinase 2 0.0291191
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0285099
NCOR1 nuclear receptor corepressor 1 0.0281543
RPL23 ribosomal protein L23 0.0279658
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0276926
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0273705
RPS14 ribosomal protein S14 0.0271094
RPL38 ribosomal protein L38 0.0267063
RPL7A ribosomal protein L7a 0.0259282
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0253118
RPLP0 ribosomal protein, large, P0 0.0252798
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0246333
PA2G4 proliferation-associated 2G4, 38kDa 0.024532
EIF5B eukaryotic translation initiation factor 5B 0.0241019
ATP5F1E ATP synthase F1 subunit epsilon 0.0240591
RPL10A ribosomal protein L10a 0.023876
RPS13 ribosomal protein S13 0.0235538
COX6C cytochrome c oxidase subunit VIc 0.0234267
IRS2 insulin receptor substrate 2 0.0231618
RPL5 ribosomal protein L5 0.0226559
CENPF centromere protein F, 350/400kDa 0.0218147
RPL34 ribosomal protein L34 0.021803
TXNRD1 thioredoxin reductase 1 0.021339
SCG2 secretogranin II 0.0210553
RPL36AL ribosomal protein L36a-like 0.0208184
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0206153
KPNB1 karyopherin (importin) beta 1 0.0205917
GPHN gephyrin 0.0202837
RPL30 ribosomal protein L30 0.0202688
RPLP2 ribosomal protein, large, P2 0.0194214
TTC19 tetratricopeptide repeat domain 19 0.0190285
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.0185668
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0183339
RPL15 ribosomal protein L15 0.0183072
NIPSNAP2 nipsnap homolog 2 0.0182375
RPL36A ribosomal protein L36a 0.018188
PTMA prothymosin, alpha 0.0180759
GOLGA4 golgin A4 0.0179107
SCFD1 sec1 family domain containing 1 0.0178388
GRIK1 glutamate receptor, ionotropic, kainate 1 0.0178098
NDUFA4 NDUFA4, mitochondrial complex associated 0.0177853
ATF4 activating transcription factor 4 0.0177398
SLC38A2 solute carrier family 38, member 2 0.0177098
NIPBL Nipped-B homolog (Drosophila) 0.0176923
CHGA chromogranin A 0.0176603
TFF3 trefoil factor 3 (intestinal) 0.0176289

decreased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 -0.0851771
VGF VGF nerve growth factor inducible -0.0721278
ESRRG estrogen-related receptor gamma -0.0636822
NALF1 NALCN channel auxiliary factor 1 -0.0583982
PDE10A phosphodiesterase 10A -0.0551833
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.054935
PEG10 paternally expressed 10 -0.0537393
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0523462
TENM1 teneurin transmembrane protein 1 -0.0472737
MYH9 myosin, heavy chain 9, non-muscle -0.0458769
MCL1 myeloid cell leukemia 1 -0.0447127
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0437806
GPC6 glypican 6 -0.0395522
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.038809
RPH3AL rabphilin 3A-like (without C2 domains) -0.0385053
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 -0.0377925
IGFBP5 insulin-like growth factor binding protein 5 -0.0376396
UBC ubiquitin C -0.0374675
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -0.0371123
CADM1 cell adhesion molecule 1 -0.0364445
GRB10 growth factor receptor-bound protein 10 -0.0358957
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.035708
RORA RAR-related orphan receptor A -0.0356859
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.0336738
CHGB chromogranin B -0.0312595
SMYD3 SET and MYND domain containing 3 -0.0294729
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0292209
PCSK1 proprotein convertase subtilisin/kexin type 1 -0.0281005
LOC112694756 uncharaterized LOC112694756 -0.0278775
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0266752
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0264136
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0261297
PCBP3 poly(rC) binding protein 3 -0.0259669
APP amyloid beta (A4) precursor protein -0.0258308
MARCHF6 membrane associated ring-CH-type finger 6 -0.0257974
EFNA5 ephrin-A5 -0.0255538
NELL1 NEL-like 1 (chicken) -0.0254405
PCBP2 poly(rC) binding protein 2 -0.0248673
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0242148
NBAS neuroblastoma amplified sequence -0.0241868
RAD51B RAD51 paralog B -0.0240555
RNF213 ring finger protein 213 -0.023932
AUTS2 autism susceptibility candidate 2 -0.0234991
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0229243
KCNMB3 potassium channel subfamily M regulatory beta subunit 3 -0.0221787
POU2F1 POU class 2 homeobox 1 -0.0220168
EGR1 early growth response 1 -0.0219571
NCAM1 neural cell adhesion molecule 1 -0.021804
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0214883
MBNL2 muscleblind-like splicing regulator 2 -0.0214179
MAML3 mastermind-like 3 (Drosophila) -0.0211422
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0210992
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0210353
SFPQ splicing factor proline/glutamine-rich -0.0210349
CA8 carbonic anhydrase VIII -0.0207387
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0206354
CANX calnexin -0.020362
NKAIN2 Na+/K+ transporting ATPase interacting 2 -0.0202891
SLCO3A1 solute carrier organic anion transporter family, member 3A1 -0.0201254
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit -0.0194659
GMDS GDP-mannose 4,6-dehydratase -0.019285
NINL ninein-like -0.0192325
GSE1 Gse1 coiled-coil protein -0.0188305
HMGB2 high mobility group box 2 -0.0187378
TSPYL2 TSPY-like 2 -0.0185232
KDM5C lysine (K)-specific demethylase 5C -0.0184024
MSI2 musashi RNA-binding protein 2 -0.0183949
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0182979
DGKD diacylglycerol kinase, delta 130kDa -0.0182851
KLHL29 kelch-like family member 29 -0.0182178
RIMBP2 RIMS binding protein 2 -0.0181966
JAZF1 JAZF zinc finger 1 -0.0179171
RAD21 RAD21 homolog (S. pombe) -0.0177847
ZNF407 zinc finger protein 407 -0.0176813
SDK1 sidekick cell adhesion molecule 1 -0.01765
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 -0.0175419
ARHGAP26 Rho GTPase activating protein 26 -0.0174903
LRFN2 leucine rich repeat and fibronectin type III domain containing 2 -0.0173688
TM9SF3 transmembrane 9 superfamily member 3 -0.0173386
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -0.017181
IGF1R insulin-like growth factor 1 receptor -0.01718
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 -0.0170072
SPIDR scaffolding protein involved in DNA repair -0.016877
JUN jun proto-oncogene -0.016619
MYT1L myelin transcription factor 1-like -0.0165667
FBXO34 F-box protein 34 -0.0164942
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0164107
KIF26B kinesin family member 26B -0.0163508
MYH10 myosin, heavy chain 10, non-muscle -0.0163489
NLGN1 neuroligin 1 -0.016288
ZFC3H1 zinc finger, C3H1-type containing -0.0162518
TUBGCP3 tubulin, gamma complex associated protein 3 -0.0162507
IQSEC1 IQ motif and Sec7 domain 1 -0.0161816
HELZ helicase with zinc finger -0.0159416
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0159298
LIFR leukemia inhibitory factor receptor alpha -0.0159053
JAM3 junctional adhesion molecule 3 -0.01569
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0156747
EIPR1 EARP complex and GARP complex interacting protein 1 -0.0156382
RIT2 Ras-like without CAAX 2 -0.015637