9-ING-41_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 9-ING-41 perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 9-ING-41_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.111348
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0956903
SQSTM1 sequestosome 1 0.0945459
RPS3 ribosomal protein S3 0.0796
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.076901
RPS6 ribosomal protein S6 0.0736223
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0701389
ENO1 enolase 1, (alpha) 0.0671241
EEF2 eukaryotic translation elongation factor 2 0.0630653
RPS12 ribosomal protein S12 0.0598172
AKAP12 A kinase (PRKA) anchor protein 12 0.0596628
ANGPTL4 angiopoietin-like 4 0.058134
IFI6 interferon, alpha-inducible protein 6 0.0554116
SFTPA2 surfactant protein A2 0.0551449
PABPC1 poly(A) binding protein, cytoplasmic 1 0.054876
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0539941
B2M beta-2-microglobulin 0.0535649
EIF1 eukaryotic translation initiation factor 1 0.0533868
TPT1 tumor protein, translationally-controlled 1 0.0458529
CTSB cathepsin B 0.0447088
RPS8 ribosomal protein S8 0.0437004
HDAC9 histone deacetylase 9 0.0414302
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0409304
TM4SF1 transmembrane 4 L six family member 1 0.0404539
SP100 SP100 nuclear antigen 0.0403784
LAMP2 lysosomal-associated membrane protein 2 0.0373985
RACK1 receptor for activated C kinase 1 0.0371735
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0362718
RPS13 ribosomal protein S13 0.0360908
BPTF bromodomain PHD finger transcription factor 0.0354891
MKI67 marker of proliferation Ki-67 0.0344176
RPL37A ribosomal protein L37a 0.034395
RPS23 ribosomal protein S23 0.0312176
HLA-B major histocompatibility complex, class I, B 0.0304723
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0298364
RPL12 ribosomal protein L12 0.0288905
ZBTB20 zinc finger and BTB domain containing 20 0.0286319
RPS17 ribosomal protein S17 0.0285455
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0284556
ANXA2 annexin A2 0.0281898
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0276612
RPL23 ribosomal protein L23 0.0272408
IFI16 interferon, gamma-inducible protein 16 0.0269917
APOD apolipoprotein D 0.0262811
KTN1 kinectin 1 (kinesin receptor) 0.0261707
ALCAM activated leukocyte cell adhesion molecule 0.0261662
IFIH1 interferon induced with helicase C domain 1 0.0259798
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0257932
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.025513
SET SET nuclear proto-oncogene 0.02496
CD44 CD44 molecule (Indian blood group) 0.0248516
PKM pyruvate kinase, muscle 0.0248384
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0246528
FTL ferritin, light polypeptide 0.0242192
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0238362
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0235413
SAMD9 sterile alpha motif domain containing 9 0.023531
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.0234103
RPLP1 ribosomal protein, large, P1 0.0232153
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0231065
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0230801
PMP22 peripheral myelin protein 22 0.023008
RPS2 ribosomal protein S2 0.0229452
CENPF centromere protein F, 350/400kDa 0.0226712
IL6ST interleukin 6 signal transducer 0.0225331
HLA-E major histocompatibility complex, class I, E 0.0223408
RPL35A ribosomal protein L35a 0.0221908
RPL36A ribosomal protein L36a 0.0221477
KPNB1 karyopherin (importin) beta 1 0.0220707
DCAF7 DDB1 and CUL4 associated factor 7 0.0217804
RPS27 ribosomal protein S27 0.0213453
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0212493
RPS29 ribosomal protein S29 0.0211847
RPL31 ribosomal protein L31 0.0211011
RPS16 ribosomal protein S16 0.0209612
NAP1L1 nucleosome assembly protein 1-like 1 0.0208564
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0208445
LOC102724023 ES1 protein homolog, mitochondrial 0.0208367
DST dystonin 0.0207131
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.0204663
EIF5 eukaryotic translation initiation factor 5 0.0203214
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0202805
RPS25 ribosomal protein S25 0.0201517
SEPTIN7 septin 7 0.0199582
RPL15 ribosomal protein L15 0.0199202
RPS27A ribosomal protein S27a 0.01978
DTX3L deltex 3 like, E3 ubiquitin ligase 0.0196613
PLSCR1 phospholipid scramblase 1 0.0195892
NAV2 neuron navigator 2 0.0195484
UBC ubiquitin C 0.0194788
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.019445
RPS14 ribosomal protein S14 0.0192979
SCAF11 SR-related CTD-associated factor 11 0.0191406
MED13 mediator complex subunit 13 0.0190554
FRMD5 FERM domain containing 5 0.0190329
KLF6 Kruppel-like factor 6 0.0190305
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0189026
C6ORF62 chromosome 6 open reading frame 62 0.0188663
RPL7 ribosomal protein L7 0.0188463
PNRC1 proline-rich nuclear receptor coactivator 1 0.0187812

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.218486
NLGN1 neuroligin 1 -0.134164
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.124935
NRG3 neuregulin 3 -0.102727
LSAMP limbic system-associated membrane protein -0.102598
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0916084
MSI2 musashi RNA-binding protein 2 -0.0880086
SLC39A11 solute carrier family 39, member 11 -0.0696043
CADM1 cell adhesion molecule 1 -0.063422
RAD51B RAD51 paralog B -0.0587187
SREBF2 sterol regulatory element binding transcription factor 2 -0.0580268
FHIT fragile histidine triad -0.0570823
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0538433
CNIH3 cornichon family AMPA receptor auxiliary protein 3 -0.0535738
FNDC3B fibronectin type III domain containing 3B -0.0533307
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0529653
MAML3 mastermind-like 3 (Drosophila) -0.0493575
PRELID2 PRELI domain containing 2 -0.0437677
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0425771
TNNC1 troponin C type 1 (slow) -0.0425659
SMYD3 SET and MYND domain containing 3 -0.0422351
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0410256
FRMD4A FERM domain containing 4A -0.0406753
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0402491
IGF1R insulin-like growth factor 1 receptor -0.0386043
SBF2 SET binding factor 2 -0.0372652
BIRC6 baculoviral IAP repeat containing 6 -0.0369902
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -0.036869
CDH13 cadherin 13 -0.0357674
IL1RAP interleukin 1 receptor accessory protein -0.0357408
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0354671
LRMDA leucine rich melanocyte differentiation associated -0.0352727
ASPH aspartate beta-hydroxylase -0.0341714
FMNL2 formin-like 2 -0.0337522
KAZN kazrin, periplakin interacting protein -0.0325181
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0322798
DLG1 discs, large homolog 1 (Drosophila) -0.0310795
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.030143
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0300016
EXT1 exostosin glycosyltransferase 1 -0.029622
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0280799
PTK2 protein tyrosine kinase 2 -0.0280667
FYN FYN proto-oncogene, Src family tyrosine kinase -0.027914
CLIP4 CAP-GLY domain containing linker protein family, member 4 -0.0274441
FMN1 formin 1 -0.0271701
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0271177
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0264337
LCORL ligand dependent nuclear receptor corepressor-like -0.0259293
OGT O-linked N-acetylglucosamine (GlcNAc) transferase -0.0259052
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0258836
EYA1 EYA transcriptional coactivator and phosphatase 1 -0.0258807
SMAD3 SMAD family member 3 -0.0258715
PTPRM protein tyrosine phosphatase, receptor type, M -0.0255427
PDE10A phosphodiesterase 10A -0.0254645
FLNB filamin B, beta -0.0253213
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0251187
ANKRD11 ankyrin repeat domain 11 -0.0244817
CA8 carbonic anhydrase VIII -0.0243358
LDLRAD3 low density lipoprotein receptor class A domain containing 3 -0.0242273
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0242171
CHD6 chromodomain helicase DNA binding protein 6 -0.0241803
CABIN1 calcineurin binding protein 1 -0.0241222
MARCHF1 membrane associated ring-CH-type finger 1 -0.0240868
LEF1 lymphoid enhancer-binding factor 1 -0.0239661
IARS1 isoleucyl-tRNA synthetase 1 -0.0238645
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0238297
GOLGA4 golgin A4 -0.0237499
CTBP2 C-terminal binding protein 2 -0.0237412
GRB10 growth factor receptor-bound protein 10 -0.0236907
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 -0.0234543
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0233186
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0230805
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 -0.0230426
ZNF292 zinc finger protein 292 -0.022594
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0224932
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0224273
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0222682
HDAC4 histone deacetylase 4 -0.0219454
TNIK TRAF2 and NCK interacting kinase -0.0217373
HSPG2 heparan sulfate proteoglycan 2 -0.0217252
POU2F1 POU class 2 homeobox 1 -0.0217241
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0216357
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.021635
CNKSR3 CNKSR family member 3 -0.0215588
TFRC transferrin receptor -0.0213756
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.0212665
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0212607
ZMYND8 zinc finger, MYND-type containing 8 -0.0211018
CELF2 CUGBP, Elav-like family member 2 -0.0210987
JARID2 jumonji, AT rich interactive domain 2 -0.0209533
ZNF638 zinc finger protein 638 -0.0207818
NPAS2 neuronal PAS domain protein 2 -0.0207757
GSK3B glycogen synthase kinase 3 beta -0.0207335
NRXN3 neurexin 3 -0.020326
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0203214
SOX5 SRY (sex determining region Y)-box 5 -0.0202859
DPP6 dipeptidyl-peptidase 6 -0.0201683
USP3 ubiquitin specific peptidase 3 -0.0200937
TBC1D22A TBC1 domain family, member 22A -0.0200206
FOXJ3 forkhead box J3 -0.0198306