9-ING-41_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 9-ING-41 perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 9-ING-41_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.303538
HDAC9 histone deacetylase 9 0.152875
RPS8 ribosomal protein S8 0.0756982
EEF2 eukaryotic translation elongation factor 2 0.0735924
ANXA1 annexin A1 0.071748
RPS6 ribosomal protein S6 0.0685489
ZNF608 zinc finger protein 608 0.0608672
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0542972
NCEH1 neutral cholesterol ester hydrolase 1 0.053016
EGFR epidermal growth factor receptor 0.0508611
CLIP1 CAP-GLY domain containing linker protein 1 0.0482749
SAMD4A sterile alpha motif domain containing 4A 0.0480455
CREB5 cAMP responsive element binding protein 5 0.0463475
MACROD2 MACRO domain containing 2 0.0436745
ZBTB20 zinc finger and BTB domain containing 20 0.0406424
MYOF myoferlin 0.0397118
ARL4C ADP-ribosylation factor-like 4C 0.0391033
VMP1 vacuole membrane protein 1 0.0386308
JMJD1C jumonji domain containing 1C 0.0384327
ZEB1 zinc finger E-box binding homeobox 1 0.0381118
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0375804
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0364529
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0361219
TXNRD1 thioredoxin reductase 1 0.0361211
RACK1 receptor for activated C kinase 1 0.0355127
RPS3 ribosomal protein S3 0.0353609
RPS2 ribosomal protein S2 0.03481
NCKAP1 NCK-associated protein 1 0.0344224
BCAS3 breast carcinoma amplified sequence 3 0.0342112
SQSTM1 sequestosome 1 0.034099
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0339809
TMEM65 transmembrane protein 65 0.033635
B2M beta-2-microglobulin 0.0336245
PLK2 polo-like kinase 2 0.0333664
RPL12 ribosomal protein L12 0.0328391
SLC38A2 solute carrier family 38, member 2 0.0323458
JUN jun proto-oncogene 0.0316259
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.031439
ATOSA atos homolog A 0.0314109
TXNIP thioredoxin interacting protein 0.0313597
IGF2 insulin-like growth factor 2 0.0303522
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0302178
MED13 mediator complex subunit 13 0.0299936
UBC ubiquitin C 0.0294824
ATP9B ATPase, class II, type 9B 0.0290424
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0282885
PDGFC platelet derived growth factor C 0.0282079
AHCYL2 adenosylhomocysteinase-like 2 0.0275123
PITPNB phosphatidylinositol transfer protein, beta 0.0274576
EIF1 eukaryotic translation initiation factor 1 0.0273361
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0272307
OGA O-GlcNAcase 0.0266918
LCORL ligand dependent nuclear receptor corepressor-like 0.0266657
EML4 echinoderm microtubule associated protein like 4 0.0264987
EXT1 exostosin glycosyltransferase 1 0.0264029
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.0263269
AFTPH aftiphilin 0.0261001
PRELID2 PRELI domain containing 2 0.0257598
RPS12 ribosomal protein S12 0.0252661
SGMS2 sphingomyelin synthase 2 0.0251844
RTN4 reticulon 4 0.0251326
MBNL2 muscleblind-like splicing regulator 2 0.0246291
RPL34 ribosomal protein L34 0.0244726
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0237438
XRN1 5'-3' exoribonuclease 1 0.0236659
ANKRD12 ankyrin repeat domain 12 0.0233686
TMEM87A transmembrane protein 87A 0.0233378
CSPP1 centrosome and spindle pole associated protein 1 0.0230127
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0228573
RICTOR RPTOR independent companion of MTOR, complex 2 0.0226809
TRIM24 tripartite motif containing 24 0.0226141
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 0.0225883
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0221771
UBE2H ubiquitin-conjugating enzyme E2H 0.0221648
SCAF8 SR-related CTD-associated factor 8 0.0218722
ARL15 ADP-ribosylation factor-like 15 0.0218158
CLTC clathrin, heavy chain (Hc) 0.0215147
CPNE1 copine I 0.0213026
PLPP3 phospholipid phosphatase 3 0.0212868
SFTPA2 surfactant protein A2 0.0211758
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0211186
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0208765
RB1CC1 RB1-inducible coiled-coil 1 0.0204523
KLF6 Kruppel-like factor 6 0.0204123
FTL ferritin, light polypeptide 0.0203783
MEF2A myocyte enhancer factor 2A 0.0203211
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0202174
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0201716
ZFAND3 zinc finger, AN1-type domain 3 0.0200193
TM4SF1 transmembrane 4 L six family member 1 0.019647
ZNF292 zinc finger protein 292 0.0196347
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0194732
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0193047
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0191039
FOXJ3 forkhead box J3 0.0191022
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.0190922
DUSP16 dual specificity phosphatase 16 0.0190497
IL6ST interleukin 6 signal transducer 0.0190143
ITFG1 integrin alpha FG-GAP repeat containing 1 0.0190065
ARHGAP25 Rho GTPase activating protein 25 0.0189333

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.164951
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.146467
DLG1 discs, large homolog 1 (Drosophila) -0.141312
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.136053
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.117251
BMP10 bone morphogenetic protein 10 -0.110475
NPAS2 neuronal PAS domain protein 2 -0.0803785
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0788344
FLNB filamin B, beta -0.077114
GLI3 GLI family zinc finger 3 -0.0767565
FOXP1 forkhead box P1 -0.0762859
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0760093
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0757806
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0667255
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0628129
UNC13A unc-13 homolog A (C. elegans) -0.0600889
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0596621
CCND1 cyclin D1 -0.0595397
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0591999
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0589419
ECT2 epithelial cell transforming 2 -0.0562997
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0532974
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0515662
TMSB4X thymosin beta 4, X-linked -0.0496255
EVI5 ecotropic viral integration site 5 -0.0492129
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0484928
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0482909
PYGB phosphorylase, glycogen; brain -0.0481858
ACTG1 actin gamma 1 -0.0475791
CUX1 cut-like homeobox 1 -0.0475684
CAMKMT calmodulin-lysine N-methyltransferase -0.0452135
TTC3 tetratricopeptide repeat domain 3 -0.0449092
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0448575
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0445359
TAS2R14 taste receptor, type 2, member 14 -0.0441492
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0438843
PDE7B phosphodiesterase 7B -0.0429798
NEBL nebulette -0.0421265
PKM pyruvate kinase, muscle -0.0411888
CALR calreticulin -0.0409093
BMP2K BMP2 inducible kinase -0.0406355
POTEF POTE ankyrin domain family, member F -0.0401433
PDE4B phosphodiesterase 4B, cAMP-specific -0.039662
TTC28 tetratricopeptide repeat domain 28 -0.0395232
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0394175
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0391392
GSE1 Gse1 coiled-coil protein -0.0375073
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0374956
PFN1 profilin 1 -0.0362837
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0360784
NFIA nuclear factor I/A -0.0359292
GLS2 glutaminase 2 (liver, mitochondrial) -0.0349557
GOLGA4 golgin A4 -0.0342747
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0339357
LDHA lactate dehydrogenase A -0.033223
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0331344
LOC112694756 uncharaterized LOC112694756 -0.0327274
GPHN gephyrin -0.0321478
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0312649
EBNA1BP2 EBNA1 binding protein 2 -0.0312083
RAD18 RAD18 E3 ubiquitin protein ligase -0.0312009
PKP4 plakophilin 4 -0.031178
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0308362
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -0.0304939
SOX6 SRY (sex determining region Y)-box 6 -0.0303387
SMIM44 small integral membrane protein 44 -0.0302225
RRBP1 ribosome binding protein 1 -0.0301926
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0301653
RBM8A RNA binding motif protein 8A -0.0299641
SBF2 SET binding factor 2 -0.0296805
CD47 CD47 molecule -0.0295285
ONECUT2 one cut homeobox 2 -0.029371
DGKH diacylglycerol kinase, eta -0.0292675
TBCA tubulin folding cofactor A -0.0289033
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0288802
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 -0.0284619
DIAPH2 diaphanous-related formin 2 -0.0282019
PLXNA2 plexin A2 -0.0280102
GLI2 GLI family zinc finger 2 -0.027854
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0278047
MBNL1 muscleblind-like splicing regulator 1 -0.0276794
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF -0.027558
ITGA10 integrin, alpha 10 -0.0273323
PDGFRA platelet-derived growth factor receptor, alpha polypeptide -0.0271645
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0271442
NMD3 NMD3 ribosome export adaptor -0.0267657
TBC1D22A TBC1 domain family, member 22A -0.0266481
DENND1A DENN/MADD domain containing 1A -0.026617
TOB1 transducer of ERBB2, 1 -0.0263997
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0260006
ANKRD11 ankyrin repeat domain 11 -0.0259794
ADAM10 ADAM metallopeptidase domain 10 -0.0258341
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0258202
RPL13A ribosomal protein L13a -0.0254441
SRPK2 SRSF protein kinase 2 -0.0252358
EXOC6B exocyst complex component 6B -0.0248483
FNDC3B fibronectin type III domain containing 3B -0.0246027
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0244421
SPRY4 sprouty homolog 4 (Drosophila) -0.0243723
HJURP Holliday junction recognition protein -0.0241762