9-ING-41_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 9-ING-41 perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 9-ING-41_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.21018
MT2A metallothionein 2A 0.122753
B2M beta-2-microglobulin 0.0799266
VIM vimentin 0.0661276
UBC ubiquitin C 0.0586338
NDRG1 N-myc downstream regulated 1 0.056413
EIF1 eukaryotic translation initiation factor 1 0.044557
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0434178
FNIP1 folliculin interacting protein 1 0.0428028
KYNU kynureninase 0.0425973
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0407068
ENO1 enolase 1, (alpha) 0.0402736
RPL37A ribosomal protein L37a 0.0365342
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0363491
STC1 stanniocalcin 1 0.0354505
LDHA lactate dehydrogenase A 0.0324849
OGA O-GlcNAcase 0.0315818
TIMP3 TIMP metallopeptidase inhibitor 3 0.0290145
MTPN myotrophin 0.0285343
TPT1 tumor protein, translationally-controlled 1 0.0285159
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0282106
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0279896
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0279358
HIP1 huntingtin interacting protein 1 0.0278299
ARID4B AT rich interactive domain 4B (RBP1-like) 0.027477
S100A10 S100 calcium binding protein A10 0.0273971
ATXN1 ataxin 1 0.0271561
RPS27A ribosomal protein S27a 0.0269308
RPS23 ribosomal protein S23 0.0268914
RPS3 ribosomal protein S3 0.0263895
ADM adrenomedullin 0.0261642
INTS6 integrator complex subunit 6 0.0259244
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0252803
SPAG9 sperm associated antigen 9 0.0250605
SOD2 superoxide dismutase 2, mitochondrial 0.024669
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0244885
TRA2A transformer 2 alpha homolog (Drosophila) 0.024049
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0237555
ECE1 endothelin converting enzyme 1 0.0234819
ANKHD1 ankyrin repeat and KH domain containing 1 0.023434
RPL9 ribosomal protein L9 0.0232883
BBS9 Bardet-Biedl syndrome 9 0.0229032
AKAP9 A kinase (PRKA) anchor protein 9 0.0228225
CXCL3 chemokine (C-X-C motif) ligand 3 0.0225045
RSAD2 radical S-adenosyl methionine domain containing 2 0.0221072
PIBF1 progesterone immunomodulatory binding factor 1 0.0220773
RAB8B RAB8B, member RAS oncogene family 0.0219334
RAB10 RAB10, member RAS oncogene family 0.0218921
RPS12 ribosomal protein S12 0.0214649
PXMP2 peroxisomal membrane protein 2, 22kDa 0.0208972
DPYD dihydropyrimidine dehydrogenase 0.020688
RPS8 ribosomal protein S8 0.0206373
GRB10 growth factor receptor-bound protein 10 0.020413
TRIM56 tripartite motif containing 56 0.0201617
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 0.0201105
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 0.0198749
SEC24D SEC24 family member D 0.019858
RPL32 ribosomal protein L32 0.0195976
RYBP RING1 and YY1 binding protein 0.0194815
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0192975
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0192831
SERINC3 serine incorporator 3 0.0192595
RPS10 ribosomal protein S10 0.0192539
WAC WW domain containing adaptor with coiled-coil 0.0192443
SET SET nuclear proto-oncogene 0.0190597
SEC31A SEC31 homolog A (S. cerevisiae) 0.018934
DSCAM Down syndrome cell adhesion molecule 0.0189176
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0186781
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.0183612
EREG epiregulin 0.0183199
PAIP2 poly(A) binding protein interacting protein 2 0.0180452
RND3 Rho family GTPase 3 0.018044
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0173912
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.017376
RPS2 ribosomal protein S2 0.0173097
KDM6A lysine (K)-specific demethylase 6A 0.0172084
SSR2 signal sequence receptor, beta (translocon-associated protein beta) 0.0171653
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0170102
ERRFI1 ERBB receptor feedback inhibitor 1 0.016977
ZSWIM6 zinc finger, SWIM-type containing 6 0.016806
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0167116
JARID2 jumonji, AT rich interactive domain 2 0.0165695
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0165324
TRIP11 thyroid hormone receptor interactor 11 0.0164952
ZNF292 zinc finger protein 292 0.0164856
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0164488
AOPEP aminopeptidase O (putative) 0.0163606
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0163096
CEMIP cell migration inducing protein, hyaluronan binding 0.0162152
RIGI RNA sensor RIG-I 0.0161961
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae) 0.0160126
TOP1 topoisomerase (DNA) I 0.0160018
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0159798
IFIH1 interferon induced with helicase C domain 1 0.0159739
PCYOX1 prenylcysteine oxidase 1 0.015895
ANXA1 annexin A1 0.0158745
HM13 histocompatibility (minor) 13 0.0157832
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0157712
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 0.0156945
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0155526

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.263375
COL6A3 collagen, type VI, alpha 3 -0.145816
FN1 fibronectin 1 -0.117211
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.104925
F3 coagulation factor III (thromboplastin, tissue factor) -0.0780357
PTMA prothymosin, alpha -0.0760639
TMSB10 thymosin beta 10 -0.0626514
PSD3 pleckstrin and Sec7 domain containing 3 -0.0612314
CDH13 cadherin 13 -0.0596811
LOX lysyl oxidase -0.0587354
EGFR epidermal growth factor receptor -0.0562509
COL1A1 collagen, type I, alpha 1 -0.0558531
MT1X metallothionein 1X -0.0557866
FTH1 ferritin, heavy polypeptide 1 -0.0533965
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0526464
DST dystonin -0.0519125
LOXL2 lysyl oxidase-like 2 -0.0508613
MAP1B microtubule-associated protein 1B -0.0484364
RRBP1 ribosome binding protein 1 -0.0468734
GLIS3 GLIS family zinc finger 3 -0.0462045
ELL2 elongation factor, RNA polymerase II, 2 -0.045201
COL6A1 collagen, type VI, alpha 1 -0.0438786
POTEF POTE ankyrin domain family, member F -0.043357
CALU calumenin -0.0417013
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0410551
MYH9 myosin, heavy chain 9, non-muscle -0.0404518
COL1A2 collagen, type I, alpha 2 -0.0400994
TENT5A terminal nucleotidyltransferase 5A -0.039365
CFDP1 craniofacial development protein 1 -0.0390523
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0389798
CALR calreticulin -0.0386579
EXT1 exostosin glycosyltransferase 1 -0.0375341
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0370935
ZMYND8 zinc finger, MYND-type containing 8 -0.0366322
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0360739
VEGFA vascular endothelial growth factor A -0.035259
PDIA3 protein disulfide isomerase family A, member 3 -0.0349619
GSE1 Gse1 coiled-coil protein -0.0349193
TRIO trio Rho guanine nucleotide exchange factor -0.0347476
LAMB1 laminin, beta 1 -0.0347099
TPM4 tropomyosin 4 -0.0346809
EFNA5 ephrin-A5 -0.0344008
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0340504
FMNL2 formin-like 2 -0.0334023
MED13L mediator complex subunit 13-like -0.0321632
BACE2 beta-site APP-cleaving enzyme 2 -0.0319615
COL7A1 collagen, type VII, alpha 1 -0.0316736
FRMD4A FERM domain containing 4A -0.031602
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0312468
VCL vinculin -0.0311908
VEGFC vascular endothelial growth factor C -0.0311872
MYOF myoferlin -0.0308992
ASPH aspartate beta-hydroxylase -0.0305133
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0301855
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0297524
RNF216 ring finger protein 216 -0.0296742
NAV1 neuron navigator 1 -0.0294705
RPLP1 ribosomal protein, large, P1 -0.029126
PDE4D phosphodiesterase 4D, cAMP-specific -0.0288436
S100A9 S100 calcium binding protein A9 -0.0285377
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0283911
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.028371
ZFAND3 zinc finger, AN1-type domain 3 -0.0281652
EPAS1 endothelial PAS domain protein 1 -0.0280628
TNS3 tensin 3 -0.0270573
ACTN4 actinin, alpha 4 -0.0264867
CLINT1 clathrin interactor 1 -0.0262689
PRKCE protein kinase C, epsilon -0.0262232
BIRC6 baculoviral IAP repeat containing 6 -0.0259785
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0256287
TM4SF1 transmembrane 4 L six family member 1 -0.0256226
FOSL1 FOS-like antigen 1 -0.025581
ANKRD11 ankyrin repeat domain 11 -0.025384
PTK2 protein tyrosine kinase 2 -0.0253734
MACF1 microtubule-actin crosslinking factor 1 -0.0252362
RAI14 retinoic acid induced 14 -0.0251061
PDE10A phosphodiesterase 10A -0.0250573
SBF2 SET binding factor 2 -0.025041
COL5A1 collagen, type V, alpha 1 -0.0249871
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0248802
HLA-A major histocompatibility complex, class I, A -0.0241456
TNPO3 transportin 3 -0.0241217
MAP4 microtubule-associated protein 4 -0.0239767
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0235132
PRSS23 protease, serine, 23 -0.0234506
TTC3 tetratricopeptide repeat domain 3 -0.0231924
CADM1 cell adhesion molecule 1 -0.0231692
ITGAV integrin, alpha V -0.0231678
EGR1 early growth response 1 -0.0231491
NAMPT nicotinamide phosphoribosyltransferase -0.0231221
TPM1 tropomyosin 1 (alpha) -0.0228401
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0227876
TMSB4X thymosin beta 4, X-linked -0.0226783
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0225289
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0224069
CALD1 caldesmon 1 -0.0223926
WSB1 WD repeat and SOCS box containing 1 -0.0223088
NIPBL Nipped-B homolog (Drosophila) -0.0222698
CBX3 chromobox homolog 3 -0.0221966
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0219295