9-ING-41_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 9-ING-41 perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 9-ING-41_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.183138
LAMC2 laminin, gamma 2 0.104962
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.102837
EGFR epidermal growth factor receptor 0.101022
EEF2 eukaryotic translation elongation factor 2 0.0969887
HMGA2 high mobility group AT-hook 2 0.0969496
ACTG1 actin gamma 1 0.0904338
LAMA4 laminin, alpha 4 0.0886931
TPT1 tumor protein, translationally-controlled 1 0.0841373
IER3 immediate early response 3 0.0811272
ATXN1 ataxin 1 0.078643
CTSB cathepsin B 0.0700541
ITPKC inositol-trisphosphate 3-kinase C 0.0673559
AHNAK AHNAK nucleoprotein 0.0667139
SEPTIN9 septin 9 0.0604737
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0604333
FLOT1 flotillin 1 0.0588766
FHL2 four and a half LIM domains 2 0.0585703
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0568897
SNX9 sorting nexin 9 0.0560382
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0552071
SGPP2 sphingosine-1-phosphate phosphatase 2 0.05396
CLIP2 CAP-GLY domain containing linker protein 2 0.053646
RPL34 ribosomal protein L34 0.0532235
YAP1 Yes-associated protein 1 0.0526325
PLAUR plasminogen activator, urokinase receptor 0.0505204
NUP50 nucleoporin 50kDa 0.0502794
RPLP0 ribosomal protein, large, P0 0.0485428
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0480709
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0469504
RPS6 ribosomal protein S6 0.046799
RPL4 ribosomal protein L4 0.0454219
RCOR1 REST corepressor 1 0.0438771
ABR active BCR-related 0.0436854
SGMS2 sphingomyelin synthase 2 0.0429037
RPS2 ribosomal protein S2 0.0417094
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0406183
LOC102724023 ES1 protein homolog, mitochondrial 0.0405119
RPS8 ribosomal protein S8 0.0397362
TPM4 tropomyosin 4 0.0395785
USP9X ubiquitin specific peptidase 9, X-linked 0.0393371
RPLP1 ribosomal protein, large, P1 0.0388348
KLF6 Kruppel-like factor 6 0.038668
PDE4B phosphodiesterase 4B, cAMP-specific 0.0386526
BIRC3 baculoviral IAP repeat containing 3 0.0386421
DSPP dentin sialophosphoprotein 0.0384134
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0375184
FERMT1 fermitin family member 1 0.0371302
SMAD3 SMAD family member 3 0.036258
CDCP1 CUB domain containing protein 1 0.0356271
CPOX coproporphyrinogen oxidase 0.0353152
HSPA8 heat shock 70kDa protein 8 0.0346538
GNG4 guanine nucleotide binding protein (G protein), gamma 4 0.0328952
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0322278
KLF5 Kruppel-like factor 5 (intestinal) 0.0320046
DUSP4 dual specificity phosphatase 4 0.0319691
DSC3 desmocollin 3 0.0315932
EFNB2 ephrin-B2 0.0307774
RPL26 ribosomal protein L26 0.0304515
NTSR1 neurotensin receptor 1 (high affinity) 0.0304194
MACF1 microtubule-actin crosslinking factor 1 0.0302413
TES testin LIM domain protein 0.0300306
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0298746
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0289499
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0287827
EXT1 exostosin glycosyltransferase 1 0.0286094
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0280548
SLC30A10 solute carrier family 30, member 10 0.027702
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0271785
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0269822
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0263594
ARL5B ADP-ribosylation factor-like 5B 0.0259709
EPCAM epithelial cell adhesion molecule 0.0257468
RPS13 ribosomal protein S13 0.0256529
FBXL17 F-box and leucine-rich repeat protein 17 0.0255099
NCEH1 neutral cholesterol ester hydrolase 1 0.0254343
ENO1 enolase 1, (alpha) 0.0254189
RPL31 ribosomal protein L31 0.0253164
DSG2 desmoglein 2 0.024989
MKI67 marker of proliferation Ki-67 0.0248978
CENPF centromere protein F, 350/400kDa 0.024816
RPL23 ribosomal protein L23 0.0243798
RPS20 ribosomal protein S20 0.0243193
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.024134
ZSWIM6 zinc finger, SWIM-type containing 6 0.0241054
ZHX2 zinc fingers and homeoboxes 2 0.0240771
RACK1 receptor for activated C kinase 1 0.0236813
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0236409
BPTF bromodomain PHD finger transcription factor 0.0236064
RSL1D1 ribosomal L1 domain containing 1 0.0233405
HOMER1 homer scaffolding protein 1 0.0231202
RPS5 ribosomal protein S5 0.0229795
EMP1 epithelial membrane protein 1 0.0227436
RPL7 ribosomal protein L7 0.0223178
WWOX WW domain containing oxidoreductase 0.02231
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0221241
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0220929
POTEF POTE ankyrin domain family, member F 0.021967
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0217821
GCLC glutamate-cysteine ligase, catalytic subunit 0.0216298

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.148571
FRAS1 Fraser extracellular matrix complex subunit 1 -0.107787
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.101709
TMSB10 thymosin beta 10 -0.0932897
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.093287
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0828443
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0645452
ESYT2 extended synaptotagmin-like protein 2 -0.0596742
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0591361
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0546847
IGFBP3 insulin-like growth factor binding protein 3 -0.0545493
OSBPL3 oxysterol binding protein-like 3 -0.0519755
RBM25 RNA binding motif protein 25 -0.0515545
HDAC2 histone deacetylase 2 -0.050278
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0481553
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0480389
NCOR2 nuclear receptor corepressor 2 -0.0458472
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor -0.0456967
GOLGA4 golgin A4 -0.0455884
BRWD1 bromodomain and WD repeat domain containing 1 -0.0453948
RNF145 ring finger protein 145 -0.0447352
CD36 CD36 molecule (thrombospondin receptor) -0.0442856
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0441865
NDRG1 N-myc downstream regulated 1 -0.0438449
GARS1 glycyl-tRNA synthetase 1 -0.0437331
EZR ezrin -0.0431596
FMNL2 formin-like 2 -0.0426097
NFIA nuclear factor I/A -0.0419207
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.040295
COG5 component of oligomeric golgi complex 5 -0.0395888
RAD51B RAD51 paralog B -0.0387085
FAM3C family with sequence similarity 3, member C -0.0381107
PDLIM5 PDZ and LIM domain 5 -0.0379767
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0376429
WDR43 WD repeat domain 43 -0.0370333
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0366159
PCBP2 poly(rC) binding protein 2 -0.0365987
ZBTB7C zinc finger and BTB domain containing 7C -0.0364881
TRIO trio Rho guanine nucleotide exchange factor -0.0362362
FNDC3B fibronectin type III domain containing 3B -0.0361509
USP3 ubiquitin specific peptidase 3 -0.0358173
PTMA prothymosin, alpha -0.0355665
TOP1 topoisomerase (DNA) I -0.035445
DENND1A DENN/MADD domain containing 1A -0.0352595
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0350499
GDF15 growth differentiation factor 15 -0.0348455
SERINC5 serine incorporator 5 -0.0341136
MYO1B myosin IB -0.0339362
NBAS neuroblastoma amplified sequence -0.0330885
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0329123
RREB1 ras responsive element binding protein 1 -0.0328595
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0328267
PTK2 protein tyrosine kinase 2 -0.0322817
KDM6A lysine (K)-specific demethylase 6A -0.0320513
KLF3 Kruppel-like factor 3 (basic) -0.031939
PUM2 pumilio RNA-binding family member 2 -0.0319228
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0318531
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.0317992
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0314539
FAM120A family with sequence similarity 120A -0.0309163
LDHA lactate dehydrogenase A -0.0307374
RUNX2 runt-related transcription factor 2 -0.0307256
MPRIP myosin phosphatase Rho interacting protein -0.0294768
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0292627
NFXL1 nuclear transcription factor, X-box binding-like 1 -0.0291076
FAR1 fatty acyl CoA reductase 1 -0.0290723
PARD3 par-3 family cell polarity regulator -0.0290239
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0289691
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0288589
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0288401
SFPQ splicing factor proline/glutamine-rich -0.0283849
EWSR1 EWS RNA-binding protein 1 -0.0280958
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0280114
BIRC6 baculoviral IAP repeat containing 6 -0.027799
ZMYM2 zinc finger, MYM-type 2 -0.027699
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0274423
STRN3 striatin, calmodulin binding protein 3 -0.0273448
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0270687
ZNF292 zinc finger protein 292 -0.0270052
EP400 E1A binding protein p400 -0.0269942
MBNL1 muscleblind-like splicing regulator 1 -0.0268556
UBE3C ubiquitin protein ligase E3C -0.026784
CEP152 centrosomal protein 152kDa -0.0265755
PALS2 protein associated with LIN7 2, MAGUK p55 family member -0.0264157
SREBF2 sterol regulatory element binding transcription factor 2 -0.02611
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0260351
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0259953
NCOR1 nuclear receptor corepressor 1 -0.0255334
SRRM2 serine/arginine repetitive matrix 2 -0.0253442
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0253349
SETD5 SET domain containing 5 -0.0253282
TXNRD1 thioredoxin reductase 1 -0.0253118
TXNIP thioredoxin interacting protein -0.0252089
OXR1 oxidation resistance 1 -0.0249292
FYN FYN proto-oncogene, Src family tyrosine kinase -0.024787
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.024769
TBCD tubulin folding cofactor D -0.0246749
PTBP2 polypyrimidine tract binding protein 2 -0.0245969
XYLT1 xylosyltransferase I -0.0245937
CCNL1 cyclin L1 -0.0245611