9-ING-41_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 9-ING-41 perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 9-ING-41_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.229218
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.193159
RPS12 ribosomal protein S12 0.0858284
RPS6 ribosomal protein S6 0.0814526
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0800323
RPS3 ribosomal protein S3 0.0777993
MT2A metallothionein 2A 0.0754343
EEF2 eukaryotic translation elongation factor 2 0.0752743
RPS8 ribosomal protein S8 0.0586176
TNS3 tensin 3 0.0583933
RPL26 ribosomal protein L26 0.0557883
RPL23 ribosomal protein L23 0.0549028
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0496749
SVIL supervillin 0.0489425
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0481815
RPS19 ribosomal protein S19 0.0474255
LMO7 LIM domain 7 0.0465291
RPL12 ribosomal protein L12 0.0453186
RPL32 ribosomal protein L32 0.0444393
EIF1 eukaryotic translation initiation factor 1 0.0425587
RPLP2 ribosomal protein, large, P2 0.0421503
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0414829
RPS23 ribosomal protein S23 0.041323
RPL36 ribosomal protein L36 0.0408884
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0403901
RPS4X ribosomal protein S4, X-linked 0.0400337
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0395002
RPL7 ribosomal protein L7 0.0394254
RPLP1 ribosomal protein, large, P1 0.038164
RPL18 ribosomal protein L18 0.0378591
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0368198
RPS17 ribosomal protein S17 0.0366736
PCLO piccolo presynaptic cytomatrix protein 0.0366644
RPS2 ribosomal protein S2 0.0366489
RPL37 ribosomal protein L37 0.0365742
ANKRD28 ankyrin repeat domain 28 0.0352311
RPL37A ribosomal protein L37a 0.0342287
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0335071
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0332002
SYT1 synaptotagmin I 0.0328676
BMP5 bone morphogenetic protein 5 0.0323619
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0320119
MBNL2 muscleblind-like splicing regulator 2 0.0320028
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0317241
SERINC5 serine incorporator 5 0.0307207
RPL11 ribosomal protein L11 0.0302957
COBL cordon-bleu WH2 repeat protein 0.0299892
RPS13 ribosomal protein S13 0.0298494
RACK1 receptor for activated C kinase 1 0.0296532
CEMIP2 cell migration inducing hyaluronidase 2 0.0294721
NIPBL Nipped-B homolog (Drosophila) 0.02882
FOXP1 forkhead box P1 0.0287802
CTNND1 catenin (cadherin-associated protein), delta 1 0.0282129
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0278606
RPS29 ribosomal protein S29 0.0278314
EMP1 epithelial membrane protein 1 0.0277667
NEBL nebulette 0.0276558
WNK1 WNK lysine deficient protein kinase 1 0.0275429
KLF6 Kruppel-like factor 6 0.0271327
RPL28 ribosomal protein L28 0.0267998
SIK3 SIK family kinase 3 0.0263543
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0262598
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0262592
RPS11 ribosomal protein S11 0.0261776
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0261745
EXPH5 exophilin 5 0.0257087
DST dystonin 0.0250794
ETNK1 ethanolamine kinase 1 0.0246552
RPL5 ribosomal protein L5 0.0244327
SOX9 SRY (sex determining region Y)-box 9 0.0242205
ATXN1 ataxin 1 0.0239915
DSPP dentin sialophosphoprotein 0.0239352
ARHGAP42 Rho GTPase activating protein 42 0.0238323
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0238005
KLF12 Kruppel-like factor 12 0.023572
GCLC glutamate-cysteine ligase, catalytic subunit 0.0235521
TJP1 tight junction protein 1 0.0229385
DIAPH3 diaphanous-related formin 3 0.0229209
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.0226655
MPG N-methylpurine-DNA glycosylase 0.0225922
RPS27 ribosomal protein S27 0.0225882
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0222974
ZEB1 zinc finger E-box binding homeobox 1 0.0222925
USP9X ubiquitin specific peptidase 9, X-linked 0.0218947
ARGLU1 arginine and glutamate rich 1 0.02188
ARL15 ADP-ribosylation factor-like 15 0.02166
RPL21 ribosomal protein L21 0.0216128
WWOX WW domain containing oxidoreductase 0.0214732
LOC102724023 ES1 protein homolog, mitochondrial 0.0213368
RPL8 ribosomal protein L8 0.0211995
RPL31 ribosomal protein L31 0.0211195
JMJD1C jumonji domain containing 1C 0.0209755
MACC1 metastasis associated in colon cancer 1 0.0207825
TXNIP thioredoxin interacting protein 0.0206339
UTRN utrophin 0.0205765
DUSP6 dual specificity phosphatase 6 0.0205253
PDE8A phosphodiesterase 8A 0.0204922
EFNB2 ephrin-B2 0.0203569
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0203548
SON SON DNA binding protein 0.0203512

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.171553
CDH13 cadherin 13 -0.12289
KRT18 keratin 18, type I -0.118391
NKD1 naked cuticle homolog 1 (Drosophila) -0.111544
CCND1 cyclin D1 -0.107645
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.105694
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.103919
SDK1 sidekick cell adhesion molecule 1 -0.0933287
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.091314
NAV2 neuron navigator 2 -0.0852759
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0750432
VCL vinculin -0.0723256
AKAP12 A kinase (PRKA) anchor protein 12 -0.0709877
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0701474
ANO1 anoctamin 1, calcium activated chloride channel -0.0649004
TPM4 tropomyosin 4 -0.0648313
KRT8 keratin 8, type II -0.0642565
CANX calnexin -0.0610431
MRPS6 mitochondrial ribosomal protein S6 -0.0568792
ITGB4 integrin, beta 4 -0.0536252
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0527223
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0526843
INTS6 integrator complex subunit 6 -0.0488355
ADGRL2 adhesion G protein-coupled receptor L2 -0.0472244
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.047072
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0437943
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.043332
LDHA lactate dehydrogenase A -0.0430687
BACE2 beta-site APP-cleaving enzyme 2 -0.0428693
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0424013
SKAP1 src kinase associated phosphoprotein 1 -0.0419974
MAML2 mastermind-like 2 (Drosophila) -0.0417544
RAD51B RAD51 paralog B -0.0413375
TMSB4X thymosin beta 4, X-linked -0.0406759
FLNB filamin B, beta -0.0394454
NPAS2 neuronal PAS domain protein 2 -0.0376348
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0375919
ZMYND8 zinc finger, MYND-type containing 8 -0.0364776
HDAC4 histone deacetylase 4 -0.0354047
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0349332
FTH1 ferritin, heavy polypeptide 1 -0.0348046
IGFBP3 insulin-like growth factor binding protein 3 -0.0344591
IGF1R insulin-like growth factor 1 receptor -0.0342647
PKM pyruvate kinase, muscle -0.0336923
ACTN1 actinin, alpha 1 -0.033209
CDK6 cyclin-dependent kinase 6 -0.0331317
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.033048
MYOF myoferlin -0.0324453
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0324013
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0321568
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0313872
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0310913
TFRC transferrin receptor -0.0304879
AHNAK AHNAK nucleoprotein -0.0301719
NTSR1 neurotensin receptor 1 (high affinity) -0.0298677
GTF2IRD1 GTF2I repeat domain containing 1 -0.0297835
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 -0.028781
MACF1 microtubule-actin crosslinking factor 1 -0.0287697
ANLN anillin, actin binding protein -0.0283791
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.027645
CUX1 cut-like homeobox 1 -0.027598
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0272323
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0265923
TNIK TRAF2 and NCK interacting kinase -0.0261871
MYH9 myosin, heavy chain 9, non-muscle -0.0260564
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0258231
OSBPL3 oxysterol binding protein-like 3 -0.0253003
HMGB1 high mobility group box 1 -0.0252206
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0250161
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0250097
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.024517
PLEC plectin -0.0244273
APCDD1 adenomatosis polyposis coli down-regulated 1 -0.0244154
ANXA3 annexin A3 -0.0240232
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0239489
RBP1 retinol binding protein 1, cellular -0.0238284
IGF2 insulin-like growth factor 2 -0.0237638
ABLIM1 actin binding LIM protein 1 -0.0234589
SQSTM1 sequestosome 1 -0.0231586
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0230416
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0229642
TBC1D4 TBC1 domain family, member 4 -0.0228141
SDC4 syndecan 4 -0.0226315
TIMP2 TIMP metallopeptidase inhibitor 2 -0.022616
GMDS GDP-mannose 4,6-dehydratase -0.0225374
GOLGA4 golgin A4 -0.0224897
PDIA3 protein disulfide isomerase family A, member 3 -0.0222542
YBX1 Y box binding protein 1 -0.0222104
P4HB prolyl 4-hydroxylase, beta polypeptide -0.021956
CHD4 chromodomain helicase DNA binding protein 4 -0.0218021
TAS2R14 taste receptor, type 2, member 14 -0.0216552
SRPK2 SRSF protein kinase 2 -0.0214281
SRRM2 serine/arginine repetitive matrix 2 -0.0213167
CBX5 chromobox homolog 5 -0.0212351
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0211957
PROX1 prospero homeobox 1 -0.0205528
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0204424
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0201684
TBC1D22A TBC1 domain family, member 22A -0.0201683
S100A4 S100 calcium binding protein A4 -0.0201339