93T449 Gene Set

Dataset DepMap CRISPR Gene Dependency
Category disease or phenotype associations
Type cell line
Description Well-Differentiated Liposarcoma cell line (Cancer Dependency Map)
External Link https://depmap.org/portal/cell_line/ACH-001794
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Genes

333 gene knockdowns changing fitness of 93T449 relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

Symbol Name Standardized Value
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 23.4673
CERS3 ceramide synthase 3 22.0111
FAM3B family with sequence similarity 3, member B 18.622
ATG5 autophagy related 5 17.2756
ATG7 autophagy related 7 17.1395
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 17.0904
ATG4B autophagy related 4B, cysteine peptidase 16.0589
SOX1 SRY (sex determining region Y)-box 1 15.0187
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 12.4801
METTL13 methyltransferase like 13 11.9226
HMGA2 high mobility group AT-hook 2 11.3517
NDFIP2 Nedd4 family interacting protein 2 10.6662
CHMP1B charged multivesicular body protein 1B 10.6249
NR2C1 nuclear receptor subfamily 2, group C, member 1 10.4152
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 9.4271
ADGRF5 adhesion G protein-coupled receptor F5 9.34074
PURA purine-rich element binding protein A 9.24057
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 9.13619
MARCKS myristoylated alanine-rich protein kinase C substrate 8.42781
FOXF1 forkhead box F1 8.30579
HDDC3 HD domain containing 3 8.28843
CAPS2 calcyphosine 2 8.16234
C1ORF105 chromosome 1 open reading frame 105 7.88428
FBXL4 F-box and leucine-rich repeat protein 4 7.60667
ARID3C AT rich interactive domain 3C (BRIGHT-like) 7.4159
IL1R1 interleukin 1 receptor, type I 7.11433
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase 6.92671
ATG3 autophagy related 3 6.92258
SLC25A46 solute carrier family 25, member 46 6.64338
ZNFX1 zinc finger, NFX1-type containing 1 6.5734
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 6.52461
ATG12 autophagy related 12 6.50822
RCCD1 RCC1 domain containing 1 6.37439
HBE1 hemoglobin, epsilon 1 6.19336
GFRA4 GDNF family receptor alpha 4 6.17586
MYD88 myeloid differentiation primary response 88 5.98968
GLIPR1L1 GLI pathogenesis-related 1 like 1 5.9649
SEC23A Sec23 homolog A (S. cerevisiae) 5.95335
SNX15 sorting nexin 15 5.64549
RGL1 ral guanine nucleotide dissociation stimulator-like 1 5.56297
PPTC7 PTC7 protein phosphatase homolog (S. cerevisiae) 5.44518
GH2 growth hormone 2 5.41705
CD44 CD44 molecule (Indian blood group) 5.35056
COMMD6 COMM domain containing 6 5.28832
ARNTL aryl hydrocarbon receptor nuclear translocator-like 4.97849
INPP5K inositol polyphosphate-5-phosphatase K 4.91939
RNF11 ring finger protein 11 4.89576
SLC39A1 solute carrier family 39 (zinc transporter), member 1 4.88117
MATN4 matrilin 4 4.85963
ZNF705G zinc finger protein 705G 4.82776
MAGEB3 melanoma antigen family B3 4.80392
LINGO4 leucine rich repeat and Ig domain containing 4 4.77982
PDIA3 protein disulfide isomerase family A, member 3 4.74164
ATRN attractin 4.72465
VSX2 visual system homeobox 2 4.63203
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 4.61414
NCOA5 nuclear receptor coactivator 5 4.56206
POTEE POTE ankyrin domain family, member E 4.48345
SNRK SNF related kinase 4.45852
PSD2 pleckstrin and Sec7 domain containing 2 4.45433
IL1RAP interleukin 1 receptor accessory protein 4.42398
H2AFV H2A histone family, member V 4.41934
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 4.33928
ASB9 ankyrin repeat and SOCS box containing 9 4.3097
ITM2C integral membrane protein 2C 4.27504
TIGD3 tigger transposable element derived 3 4.22094
EVPL envoplakin 4.21552
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria 4.2153
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) 4.1816
C1QC complement component 1, q subcomponent, C chain 4.17575
SLTM SAFB-like, transcription modulator 4.15512
INAFM1 InaF-motif containing 1 4.107
ATG10 autophagy related 10 4.07109
FMO3 flavin containing monooxygenase 3 4.07044
GLIPR1 GLI pathogenesis-related 1 4.05499
TFG TRK-fused gene 4.04965
ISG15 ISG15 ubiquitin-like modifier 4.01029
TRAPPC12 trafficking protein particle complex 12 3.96679
KRTAP12-2 keratin associated protein 12-2 3.92241
GHDC GH3 domain containing 3.91234
ERICH5 glutamate-rich 5 3.90004
GKN1 gastrokine 1 3.88744
NMUR1 neuromedin U receptor 1 3.88118
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 3.77629
PCDHA9 protocadherin alpha 9 3.76269
DDI2 DNA-damage inducible 1 homolog 2 (S. cerevisiae) 3.71182
CCDC177 coiled-coil domain containing 177 3.69718
SLC4A11 solute carrier family 4, sodium borate transporter, member 11 3.69061
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 3.67315
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 3.6631
OR52I1 olfactory receptor, family 52, subfamily I, member 1 3.64143
ERICH3 glutamate-rich 3 3.62428
ZNF638 zinc finger protein 638 3.60278
TREX1 three prime repair exonuclease 1 3.56879
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 3.55938
FBXO7 F-box protein 7 3.53852
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 3.49072
PCNP PEST proteolytic signal containing nuclear protein 3.45633
MAP3K7 mitogen-activated protein kinase kinase kinase 7 3.45477
ASB7 ankyrin repeat and SOCS box containing 7 3.45355
KCNK4 potassium channel, two pore domain subfamily K, member 4 3.43257
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 3.37797
ZC3H10 zinc finger CCCH-type containing 10 3.36013
NPAS2 neuronal PAS domain protein 2 3.35038
HOXD12 homeobox D12 3.34825
PDLIM5 PDZ and LIM domain 5 3.34639
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor 3.32596
EHD1 EH-domain containing 1 3.31367
C5 complement component 5 3.29153
GABARAP GABA(A) receptor-associated protein 3.27394
LEFTY2 left-right determination factor 2 3.27054
FGFR1 fibroblast growth factor receptor 1 3.23916
UVRAG UV radiation resistance associated 3.2341
IFT43 intraflagellar transport 43 3.20945
LOX lysyl oxidase 3.20879
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 3.2046
ZNF611 zinc finger protein 611 3.19516
OVOL1 ovo-like zinc finger 1 3.19406
C1QL4 complement component 1, q subcomponent-like 4 3.17306
ZNF749 zinc finger protein 749 3.16319
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase 3.14763
DHH desert hedgehog 3.13282
PTPRJ protein tyrosine phosphatase, receptor type, J 3.12249
AMT aminomethyltransferase 3.12226
NSFL1C NSFL1 (p97) cofactor (p47) 3.11665
CCL28 chemokine (C-C motif) ligand 28 3.09964
MBD2 methyl-CpG binding domain protein 2 3.0727
OR13C9 olfactory receptor, family 13, subfamily C, member 9 3.06798
FGF11 fibroblast growth factor 11 3.06001
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 3.04588
ACVR1 activin A receptor, type I 3.0321
VPS36 vacuolar protein sorting 36 homolog (S. cerevisiae) 3.00982
CD300LG CD300 molecule-like family member g 2.97822
RXFP3 relaxin/insulin-like family peptide receptor 3 2.96485
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 2.94734
VWDE von Willebrand factor D and EGF domains 2.93308
UGT3A2 UDP glycosyltransferase 3 family, polypeptide A2 2.90847
NKX2-5 NK2 homeobox 5 2.89109
BASP1 brain abundant, membrane attached signal protein 1 2.88494
RHBDD3 rhomboid domain containing 3 2.88299
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa 2.86656
TRIM5 tripartite motif containing 5 2.85905
FAHD2B fumarylacetoacetate hydrolase domain containing 2B 2.85752
AMBRA1 autophagy/beclin-1 regulator 1 2.8449
ZBED2 zinc finger, BED-type containing 2 2.83697
KYAT3 kynurenine aminotransferase 3 2.82207
MTA2 metastasis associated 1 family, member 2 2.82023
OR52N2 olfactory receptor, family 52, subfamily N, member 2 2.819
BECN1 beclin 1, autophagy related 2.79845
TRAPPC2L trafficking protein particle complex 2-like 2.79145
EGLN1 egl-9 family hypoxia-inducible factor 1 2.76595
TNNC1 troponin C type 1 (slow) 2.76413
NAA80 N-alpha-acetyltransferase 80, NatH catalytic subunit 2.76042
MARCH11 membrane-associated ring finger (C3HC4) 11 2.74633
RTP1 receptor (chemosensory) transporter protein 1 2.74283
SNTG2 syntrophin, gamma 2 2.74048
MARCH9 membrane-associated ring finger (C3HC4) 9 2.72136
MAP2K7 mitogen-activated protein kinase kinase 7 2.72131
POTEF POTE ankyrin domain family, member F 2.69443
TRAM2 translocation associated membrane protein 2 2.69388
ENHO energy homeostasis associated 2.68885
SLC66A2 solute carrier family 66 member 2 2.67482
DMTF1 cyclin D binding myb-like transcription factor 1 2.67289
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 2.66901
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 2.66864
MICU3 mitochondrial calcium uptake family, member 3 2.66534
TMEM233 transmembrane protein 233 2.65922
KLK8 kallikrein-related peptidase 8 2.65516
CAMP cathelicidin antimicrobial peptide 2.6548
MON2 MON2 homolog (S. cerevisiae) 2.65216
DSP desmoplakin 2.64334
ZBTB10 zinc finger and BTB domain containing 10 2.63816
ATXN7L3B ataxin 7-like 3B 2.62769
RIMS4 regulating synaptic membrane exocytosis 4 2.62323
AUP1 ancient ubiquitous protein 1 2.61873
GCAT glycine C-acetyltransferase 2.59963
UNC5C unc-5 homolog C (C. elegans) 2.5852
SRSF4 serine/arginine-rich splicing factor 4 2.57802
ZG16B zymogen granule protein 16B 2.57379
DERL2 derlin 2 2.55846
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 2.55577
TENT5A terminal nucleotidyltransferase 5A 2.55353
HEXIM2 hexamethylene bis-acetamide inducible 2 2.54393
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 2.54061
CCR7 chemokine (C-C motif) receptor 7 2.53195
HMGN1 high mobility group nucleosome binding domain 1 2.53065
ZNF705B zinc finger protein 705B 2.52867
UBE2G2 ubiquitin-conjugating enzyme E2G 2 2.50671
SLC25A45 solute carrier family 25, member 45 2.50644
ZDHHC23 zinc finger, DHHC-type containing 23 2.50459
FBXO42 F-box protein 42 2.49876
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 2.49858
CLOCK clock circadian regulator 2.49849
SYNDIG1L synapse differentiation inducing 1-like 2.49215
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 2.4737
RNF31 ring finger protein 31 2.46854
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2 2.46167
PHYHD1 phytanoyl-CoA dioxygenase domain containing 1 2.45761
PIGC phosphatidylinositol glycan anchor biosynthesis, class C 2.45745
SPHKAP SPHK1 interactor, AKAP domain containing 2.45435
TRAPPC13 trafficking protein particle complex 13 2.45308
CCDC124 coiled-coil domain containing 124 2.4469
DNAJC19 DnaJ (Hsp40) homolog, subfamily C, member 19 2.44456
MRGPRF MAS-related GPR, member F 2.4363
PTPRK protein tyrosine phosphatase, receptor type, K 2.43624
CST11 cystatin 11 2.43194
KCNK3 potassium channel, two pore domain subfamily K, member 3 2.43164
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 2.42668
MAN2A1 mannosidase, alpha, class 2A, member 1 2.42505
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 2.42058
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 2.41137
F2RL3 coagulation factor II (thrombin) receptor-like 3 2.40586
NHLH2 nescient helix loop helix 2 2.3991
MSX1 msh homeobox 1 2.39802
LPAR1 lysophosphatidic acid receptor 1 2.39408
ARID1A AT rich interactive domain 1A (SWI-like) 2.388
CEP250 centrosomal protein 250kDa 2.38707
NSRP1 nuclear speckle splicing regulatory protein 1 2.38682
IFNLR1 interferon, lambda receptor 1 2.38669
MAL mal, T-cell differentiation protein 2.38372
KRT74 keratin 74, type II 2.38021
SIN3B SIN3 transcription regulator family member B 2.38009
TBC1D26 TBC1 domain family, member 26 2.37691
PRODH proline dehydrogenase (oxidase) 1 2.37368
FAM150A family with sequence similarity 150, member A 2.3684
ATRX alpha thalassemia/mental retardation syndrome X-linked 2.36283
HCST hematopoietic cell signal transducer 2.36015
G6PD glucose-6-phosphate dehydrogenase 2.35899
UNC45A unc-45 homolog A (C. elegans) 2.35517
STEAP1 six transmembrane epithelial antigen of the prostate 1 2.35096
CFC1B cripto, FRL-1, cryptic family 1B 2.34394
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 2.34346
PMM2 phosphomannomutase 2 2.33977
SNX3 sorting nexin 3 2.33875
PRRT1 proline-rich transmembrane protein 1 2.33762
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 2.33675
FNDC4 fibronectin type III domain containing 4 2.33364
ZNF195 zinc finger protein 195 2.3336
IL6 interleukin 6 2.33208
CRYBB2 crystallin, beta B2 2.32734
C8B complement component 8, beta polypeptide 2.32399
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 2.3149
SMAP1 small ArfGAP 1 2.31447
GGT5 gamma-glutamyltransferase 5 2.31356
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 2.30765
CLDN9 claudin 9 2.30754
DMRTB1 DMRT-like family B with proline-rich C-terminal, 1 2.30513
EMP2 epithelial membrane protein 2 2.30004
ILKAP integrin-linked kinase-associated serine/threonine phosphatase 2.29399
TBC1D10B TBC1 domain family, member 10B 2.29342
RB1CC1 RB1-inducible coiled-coil 1 2.29158
HASPIN histone H3 associated protein kinase 2.28733
AXL AXL receptor tyrosine kinase 2.28012
FAM171A2 family with sequence similarity 171, member A2 2.27942
SLC25A38 solute carrier family 25, member 38 2.27875
DDRGK1 DDRGK domain containing 1 2.27802
CD2BP2 CD2 (cytoplasmic tail) binding protein 2 2.27592
AP4B1 adaptor-related protein complex 4, beta 1 subunit 2.27509
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) 2.27329
HBD hemoglobin, delta 2.26683
CBR1 carbonyl reductase 1 2.26631
LRRC28 leucine rich repeat containing 28 2.2646
FAM3D family with sequence similarity 3, member D 2.26143
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 2.25635
GATAD1 GATA zinc finger domain containing 1 2.25631
SPPL2A signal peptide peptidase like 2A 2.2536
CPEB4 cytoplasmic polyadenylation element binding protein 4 2.2484
GAL3ST3 galactose-3-O-sulfotransferase 3 2.24389
SETDB2 SET domain, bifurcated 2 2.23229
NOMO1 NODAL modulator 1 2.23114
CPT2 carnitine palmitoyltransferase 2 2.21045
SEPTIN2 septin 2 2.20833
LUC7L LUC7-like (S. cerevisiae) 2.20418
CD248 CD248 molecule, endosialin 2.20365
CNTNAP2 contactin associated protein-like 2 2.20348
POTEM POTE ankyrin domain family, member M 2.20296
ZNF720 zinc finger protein 720 2.19489
RHOXF2 Rhox homeobox family, member 2 2.19354
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 2.19233
OR2Y1 olfactory receptor, family 2, subfamily Y, member 1 2.19016
PLEKHH3 pleckstrin homology domain containing, family H (with MyTH4 domain) member 3 2.18904
OR52B6 olfactory receptor, family 52, subfamily B, member 6 2.18561
CAMKV CaM kinase-like vesicle-associated 2.18307
LRP1 low density lipoprotein receptor-related protein 1 2.1618
SPINK4 serine peptidase inhibitor, Kazal type 4 2.15951
CTRB1 chymotrypsinogen B1 2.15886
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 2.15015
SIX2 SIX homeobox 2 2.14856
HDHD2 haloacid dehalogenase-like hydrolase domain containing 2 2.13621
MAMSTR MEF2 activating motif and SAP domain containing transcriptional regulator 2.13565
RPRML reprimo-like 2.13421
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 2.134
OR11L1 olfactory receptor, family 11, subfamily L, member 1 2.13222
PWWP2B PWWP domain containing 2B 2.12693
NGLY1 N-glycanase 1 2.12548
DCAF8L1 DDB1 and CUL4 associated factor 8-like 1 2.12308
TMC6 transmembrane channel-like 6 2.11773
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 2.11393
KIAA1522 KIAA1522 2.10678
MMP21 matrix metallopeptidase 21 2.10648
LCN15 lipocalin 15 2.10066
UFC1 ubiquitin-fold modifier conjugating enzyme 1 2.10064
ZBTB7A zinc finger and BTB domain containing 7A 2.09168
PSD3 pleckstrin and Sec7 domain containing 3 2.08564
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 2.08464
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 2.08244
SSH3 slingshot protein phosphatase 3 2.08049
RASA3 RAS p21 protein activator 3 2.07771
OXT oxytocin/neurophysin I prepropeptide 2.07334
GCGR glucagon receptor 2.07222
CROCC ciliary rootlet coiled-coil, rootletin 2.07171
TTBK1 tau tubulin kinase 1 2.0684
C1ORF210 chromosome 1 open reading frame 210 2.06252
OR10J1 olfactory receptor, family 10, subfamily J, member 1 2.0619
OR4D6 olfactory receptor, family 4, subfamily D, member 6 2.05368
STON1 stonin 1 2.05163
STAG2 stromal antigen 2 2.05127
HTRA3 HtrA serine peptidase 3 2.04844
MVP major vault protein 2.04538
MYCBPAP MYCBP associated protein 2.04526
ZNF341 zinc finger protein 341 2.04092
ARMCX4 armadillo repeat containing, X-linked 4 2.03973
GTF2IRD1 GTF2I repeat domain containing 1 2.03439
LBP lipopolysaccharide binding protein 2.02766
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 2.02753
CCL20 chemokine (C-C motif) ligand 20 2.02023
NACC1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing 2.01854
C19ORF25 chromosome 19 open reading frame 25 2.01521
LYPD5 LY6/PLAUR domain containing 5 2.01444
SNX13 sorting nexin 13 2.00841
NOX3 NADPH oxidase 3 2.00428
OR4S2 olfactory receptor, family 4, subfamily S, member 2 2.00361
PCDHA1 protocadherin alpha 1 2.00062