94T778 Gene Set

Dataset DepMap CRISPR Gene Dependency
Category disease or phenotype associations
Type cell line
Description Well-Differentiated Liposarcoma cell line (Cancer Dependency Map)
External Link https://depmap.org/portal/cell_line/ACH-001795
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Genes

355 gene knockdowns changing fitness of 94T778 relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

Symbol Name Standardized Value
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 21.7348
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 21.3153
HINT1 histidine triad nucleotide binding protein 1 20.7331
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 16.2965
SOX1 SRY (sex determining region Y)-box 1 16.1471
CERS3 ceramide synthase 3 15.0902
METTL13 methyltransferase like 13 13.8601
C1ORF105 chromosome 1 open reading frame 105 13.4124
EFNA5 ephrin-A5 12.5776
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25 11.8339
MYO9A myosin IXA 10.7792
NR2C1 nuclear receptor subfamily 2, group C, member 1 10.743
GLIPR1 GLI pathogenesis-related 1 10.6375
ADGRF5 adhesion G protein-coupled receptor F5 10.3978
FBXO4 F-box protein 4 10.1588
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 9.85252
HMGA2 high mobility group AT-hook 2 9.60378
SIM2 single-minded family bHLH transcription factor 2 9.4052
CHSY3 chondroitin sulfate synthase 3 9.18344
H2AFV H2A histone family, member V 9.01213
NDFIP2 Nedd4 family interacting protein 2 8.89564
HDDC3 HD domain containing 3 8.69438
PDE8A phosphodiesterase 8A 7.96897
TRAT1 T cell receptor associated transmembrane adaptor 1 7.39364
ZNF853 zinc finger protein 853 7.01543
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 6.99712
ZNF705B zinc finger protein 705B 6.88969
CDC42SE2 CDC42 small effector 2 6.87544
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 6.7183
BNC1 basonuclin 1 6.51581
CEP44 centrosomal protein 44kDa 6.49046
SNCAIP synuclein, alpha interacting protein 6.48727
CPM carboxypeptidase M 6.43169
BEST3 bestrophin 3 6.28883
KIAA1024L KIAA1024-like 6.18635
GLIPR1L1 GLI pathogenesis-related 1 like 1 6.17128
ZBTB4 zinc finger and BTB domain containing 4 6.02929
RBM6 RNA binding motif protein 6 6.00712
PSIP1 PC4 and SFRS1 interacting protein 1 5.92664
FNIP1 folliculin interacting protein 1 5.91968
CNN3 calponin 3, acidic 5.82888
BICC1 BicC family RNA binding protein 1 5.60436
ATG4C autophagy related 4C, cysteine peptidase 5.59819
RHOG ras homolog family member G 5.58721
HDLBP high density lipoprotein binding protein 5.51845
NSFL1C NSFL1 (p97) cofactor (p47) 5.39467
FBXL17 F-box and leucine-rich repeat protein 17 5.30074
TTC23 tetratricopeptide repeat domain 23 5.29783
COMMD6 COMM domain containing 6 5.27514
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 5.27508
OR13C5 olfactory receptor, family 13, subfamily C, member 5 5.1245
BCL2L11 BCL2-like 11 (apoptosis facilitator) 5.10296
FRMD4A FERM domain containing 4A 5.08346
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 4.99717
PLCE1 phospholipase C, epsilon 1 4.97817
SIRT3 sirtuin 3 4.88626
TRIO trio Rho guanine nucleotide exchange factor 4.86113
IL1R1 interleukin 1 receptor, type I 4.85013
RNF25 ring finger protein 25 4.6788
SLC39A1 solute carrier family 39 (zinc transporter), member 1 4.64463
TM9SF2 transmembrane 9 superfamily member 2 4.63665
CXCL6 chemokine (C-X-C motif) ligand 6 4.61129
GOSR1 golgi SNAP receptor complex member 1 4.55461
CSK c-src tyrosine kinase 4.51165
MOCS2 molybdenum cofactor synthesis 2 4.50955
ACVR1B activin A receptor, type IB 4.49693
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 4.42323
ACVR2A activin A receptor, type IIA 4.40137
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 4.39356
PIGU phosphatidylinositol glycan anchor biosynthesis, class U 4.2977
BCAR3 breast cancer anti-estrogen resistance 3 4.29246
SLC35E3 solute carrier family 35, member E3 4.27627
USP35 ubiquitin specific peptidase 35 4.2508
TMEM204 transmembrane protein 204 4.22147
UGCG UDP-glucose ceramide glucosyltransferase 4.19965
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits 4.15616
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 4.11881
INPP5K inositol polyphosphate-5-phosphatase K 4.09475
AXL AXL receptor tyrosine kinase 4.03526
RNF11 ring finger protein 11 4.02719
RSU1 Ras suppressor protein 1 4.00948
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 3.99283
TMEM213 transmembrane protein 213 3.98016
RGL1 ral guanine nucleotide dissociation stimulator-like 1 3.95821
LPAR1 lysophosphatidic acid receptor 1 3.92822
UFSP2 UFM1-specific peptidase 2 3.91077
CTXN3 cortexin 3 3.89158
LYRM7 LYR motif containing 7 3.84342
FITM2 fat storage-inducing transmembrane protein 2 3.81276
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 3.81214
PAX8 paired box 8 3.78735
LIF leukemia inhibitory factor 3.78316
AAAS achalasia, adrenocortical insufficiency, alacrimia 3.71862
PHACTR4 phosphatase and actin regulator 4 3.67288
PRRT4 proline-rich transmembrane protein 4 3.6377
PURB purine-rich element binding protein B 3.61651
LEFTY1 left-right determination factor 1 3.53142
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 3.51912
TBX3 T-box 3 3.47959
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 3.44605
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 3.40911
WDR59 WD repeat domain 59 3.40354
DAZAP1 DAZ associated protein 1 3.40044
LMNB1 lamin B1 3.39979
MEP1A meprin A, alpha (PABA peptide hydrolase) 3.39643
UVRAG UV radiation resistance associated 3.38851
MORF4L1 mortality factor 4 like 1 3.3642
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 3.34979
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta 3.34741
TOM1L2 target of myb1-like 2 (chicken) 3.34279
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 3.33219
PIGK phosphatidylinositol glycan anchor biosynthesis, class K 3.31509
MGLL monoglyceride lipase 3.30033
DRG2 developmentally regulated GTP binding protein 2 3.28041
LUC7L LUC7-like (S. cerevisiae) 3.25768
SIK2 salt-inducible kinase 2 3.2384
RAD51B RAD51 paralog B 3.235
COG5 component of oligomeric golgi complex 5 3.211
BNC2 basonuclin 2 3.19215
BEND7 BEN domain containing 7 3.19039
API5 apoptosis inhibitor 5 3.18762
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 3.18508
PPP1R35 protein phosphatase 1, regulatory subunit 35 3.16792
EIF2A eukaryotic translation initiation factor 2A, 65kDa 3.15901
PTPN1 protein tyrosine phosphatase, non-receptor type 1 3.15458
TNR tenascin R 3.15267
BCAR1 breast cancer anti-estrogen resistance 1 3.15105
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast) 3.13948
C2ORF78 chromosome 2 open reading frame 78 3.12754
PLPP3 phospholipid phosphatase 3 3.11094
SEPTIN2 septin 2 3.09315
CRK v-crk avian sarcoma virus CT10 oncogene homolog 3.0841
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 3.07727
GPAA1 glycosylphosphatidylinositol anchor attachment 1 3.05427
SGSM3 small G protein signaling modulator 3 3.02467
SIN3B SIN3 transcription regulator family member B 3.01591
NFIC nuclear factor I/C (CCAAT-binding transcription factor) 3.01581
NUP42 nucleoporin 42 3.01431
CEP68 centrosomal protein 68kDa 3.00893
MDC1 mediator of DNA-damage checkpoint 1 2.99796
PDS5B PDS5 cohesin associated factor B 2.97477
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 2.97083
ARID4B AT rich interactive domain 4B (RBP1-like) 2.9572
DLG5 discs, large homolog 5 (Drosophila) 2.95228
OR5B2 olfactory receptor, family 5, subfamily B, member 2 2.95113
FGFR1 fibroblast growth factor receptor 1 2.94945
TFG TRK-fused gene 2.93908
PIGT phosphatidylinositol glycan anchor biosynthesis, class T 2.89957
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 2.8868
BECN1 beclin 1, autophagy related 2.88276
LCE2D late cornified envelope 2D 2.88276
USF2 upstream transcription factor 2, c-fos interacting 2.88127
ELAVL1 ELAV like RNA binding protein 1 2.86205
TBC1D10A TBC1 domain family, member 10A 2.84419
SECISBP2L SECIS binding protein 2-like 2.8346
ZBTB44 zinc finger and BTB domain containing 44 2.79078
ARID1A AT rich interactive domain 1A (SWI-like) 2.789
ZYX zyxin 2.77822
EXTL3 exostosin-like glycosyltransferase 3 2.77682
SS18 synovial sarcoma translocation, chromosome 18 2.77621
PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma 2.74572
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 2.74293
MAN2A1 mannosidase, alpha, class 2A, member 1 2.73867
MAPKAP1 mitogen-activated protein kinase associated protein 1 2.73196
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 2.72836
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2 2.7276
DOT1L DOT1-like histone H3K79 methyltransferase 2.72516
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2 2.72486
FAM170A family with sequence similarity 170, member A 2.69408
OR5D16 olfactory receptor, family 5, subfamily D, member 16 2.68888
CPEB4 cytoplasmic polyadenylation element binding protein 4 2.68484
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) 2.68397
COL13A1 collagen, type XIII, alpha 1 2.68352
DDX19A DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A 2.67871
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa 2.67365
DOCK7 dedicator of cytokinesis 7 2.66619
SEBOX SEBOX homeobox 2.66576
GLIS3 GLIS family zinc finger 3 2.65932
ERCC6L excision repair cross-complementation group 6-like 2.65249
FN3KRP fructosamine 3 kinase related protein 2.64916
CACUL1 CDK2-associated, cullin domain 1 2.64136
MARCH9 membrane-associated ring finger (C3HC4) 9 2.63775
NSRP1 nuclear speckle splicing regulatory protein 1 2.63644
GLIS1 GLIS family zinc finger 1 2.63067
TBC1D10B TBC1 domain family, member 10B 2.62422
KXD1 KxDL motif containing 1 2.62097
NEURL4 neuralized E3 ubiquitin protein ligase 4 2.6128
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 2.60477
MAGEA6 melanoma antigen family A6 2.6027
HHEX hematopoietically expressed homeobox 2.59868
NCSTN nicastrin 2.59531
ZNF319 zinc finger protein 319 2.59511
CD276 CD276 molecule 2.59461
SEPTIN9 septin 9 2.58279
BASP1 brain abundant, membrane attached signal protein 1 2.58018
VWA8 von Willebrand factor A domain containing 8 2.57036
SYTL2 synaptotagmin-like 2 2.56956
NBN nibrin 2.56025
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 2.55924
FAM13C family with sequence similarity 13, member C 2.5582
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 2.54632
TRAPPC12 trafficking protein particle complex 12 2.54507
DCLRE1C DNA cross-link repair 1C 2.54478
GLCE glucuronic acid epimerase 2.5416
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 2.54049
SEC62 SEC62 homolog (S. cerevisiae) 2.52746
CEP152 centrosomal protein 152kDa 2.52695
FBXL4 F-box and leucine-rich repeat protein 4 2.52676
FAM3B family with sequence similarity 3, member B 2.5234
C19ORF25 chromosome 19 open reading frame 25 2.5212
GUCA1B guanylate cyclase activator 1B (retina) 2.51306
FLCN folliculin 2.50284
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase 2.50065
CCDC120 coiled-coil domain containing 120 2.49646
PRB2 proline-rich protein BstNI subfamily 2 2.49631
UBALD2 UBA-like domain containing 2 2.49266
TSLIG2 tRNA splicing ligase complex subunit 2 2.48845
ELMO2 engulfment and cell motility 2 2.48533
JUN jun proto-oncogene 2.47717
AMELX amelogenin, X-linked 2.47515
NCF1 neutrophil cytosolic factor 1 2.47374
PRRC2C proline-rich coiled-coil 2C 2.47087
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 2.46031
RRAS2 related RAS viral (r-ras) oncogene homolog 2 2.44951
COG7 component of oligomeric golgi complex 7 2.44942
SERF2 small EDRK-rich factor 2 2.44718
ING2 inhibitor of growth family, member 2 2.44226
ANGPT4 angiopoietin 4 2.43879
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia) 2.43327
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 2.43112
CIDEA cell death-inducing DFFA-like effector a 2.42756
GATAD1 GATA zinc finger domain containing 1 2.42673
INPP5A inositol polyphosphate-5-phosphatase, 40kDa 2.42614
LRRTM1 leucine rich repeat transmembrane neuronal 1 2.41561
CEP295 centrosomal protein 295kDa 2.41034
SLC25A38 solute carrier family 25, member 38 2.40999
TCTEX1D1 Tctex1 domain containing 1 2.40421
MBTD1 mbt domain containing 1 2.40408
TIGD3 tigger transposable element derived 3 2.40395
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 2.40251
DCTN1 dynactin 1 2.39733
IGFALS insulin-like growth factor binding protein, acid labile subunit 2.39653
FGFR1OP2 FGFR1 oncogene partner 2 2.3963
VAC14 Vac14 homolog (S. cerevisiae) 2.39079
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 2.38833
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 2.38511
GRM2 glutamate receptor, metabotropic 2 2.38319
CTNND1 catenin (cadherin-associated protein), delta 1 2.37236
ZNF827 zinc finger protein 827 2.36732
KIFC1 kinesin family member C1 2.36635
SUN3 Sad1 and UNC84 domain containing 3 2.36362
CCR7 chemokine (C-C motif) receptor 7 2.36143
LZTS2 leucine zipper, putative tumor suppressor 2 2.35737
HLA-DOA major histocompatibility complex, class II, DO alpha 2.35413
MTMR3 myotubularin related protein 3 2.35413
FBXO42 F-box protein 42 2.35301
CD300A CD300a molecule 2.33717
SDC4 syndecan 4 2.33009
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 2.31887
SHOC2 soc-2 suppressor of clear homolog (C. elegans) 2.31782
FAHD2B fumarylacetoacetate hydrolase domain containing 2B 2.31765
ETFB electron-transfer-flavoprotein, beta polypeptide 2.31222
MSX1 msh homeobox 1 2.30722
ZFR zinc finger RNA binding protein 2.2972
OTOP3 otopetrin 3 2.2848
COG6 component of oligomeric golgi complex 6 2.27939
KLK14 kallikrein-related peptidase 14 2.26449
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2 2.26391
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 2.25984
KMT2A lysine (K)-specific methyltransferase 2A 2.25707
SSR2 signal sequence receptor, beta (translocon-associated protein beta) 2.25264
ANKRD26 ankyrin repeat domain 26 2.25125
MESD mesoderm development LRP chaperone 2.24081
ALG8 ALG8, alpha-1,3-glucosyltransferase 2.23929
PDZRN3 PDZ domain containing ring finger 3 2.23744
PIGW phosphatidylinositol glycan anchor biosynthesis, class W 2.23728
BCAP31 B-cell receptor-associated protein 31 2.23242
UNC5C unc-5 homolog C (C. elegans) 2.23197
ARMC8 armadillo repeat containing 8 2.2284
TEDC1 tubulin epsilon and delta complex 1 2.22665
SIGLEC5 sialic acid binding Ig-like lectin 5 2.22602
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 2.22565
PHF6 PHD finger protein 6 2.22248
DEF6 differentially expressed in FDCP 6 homolog (mouse) 2.21898
LCE6A late cornified envelope 6A 2.21744
NEFH neurofilament, heavy polypeptide 2.21631
DOLPP1 dolichyldiphosphatase 1 2.21389
DENND1B DENN/MADD domain containing 1B 2.20883
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 2.20227
PLIN5 perilipin 5 2.19494
YES1 YES proto-oncogene 1, Src family tyrosine kinase 2.19409
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 2.19385
PXK PX domain containing serine/threonine kinase 2.19252
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 2.18833
TMEM119 transmembrane protein 119 2.1858
WFDC5 WAP four-disulfide core domain 5 2.17919
SALL2 spalt-like transcription factor 2 2.17758
MRGPRX2 MAS-related GPR, member X2 2.17379
EBF4 early B-cell factor 4 2.17011
AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 2.1635
EML3 echinoderm microtubule associated protein like 3 2.15939
HMGXB3 HMG box domain containing 3 2.15452
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 2.14701
MATN4 matrilin 4 2.14525
YAP1 Yes-associated protein 1 2.14049
MARK2 MAP/microtubule affinity-regulating kinase 2 2.13408
TRABD TraB domain containing 2.13385
FADS6 fatty acid desaturase 6 2.12965
LIG1 ligase I, DNA, ATP-dependent 2.12911
OR2C1 olfactory receptor, family 2, subfamily C, member 1 2.11882
LIN7C lin-7 homolog C (C. elegans) 2.1151
FGFR2 fibroblast growth factor receptor 2 2.112
TMCO6 transmembrane and coiled-coil domains 6 2.11133
TRIR telomerase RNA component interacting RNase 2.10957
DNAI2 dynein, axonemal, intermediate chain 2 2.10848
CMIP c-Maf inducing protein 2.10798
ZC3H10 zinc finger CCCH-type containing 10 2.10788
UFC1 ubiquitin-fold modifier conjugating enzyme 1 2.10572
MAGEB3 melanoma antigen family B3 2.10252
RBM33 RNA binding motif protein 33 2.09901
GOLGA2 golgin A2 2.09607
RICTOR RPTOR independent companion of MTOR, complex 2 2.09541
LEMD2 LEM domain containing 2 2.09312
RANBP9 RAN binding protein 9 2.09257
MRC2 mannose receptor, C type 2 2.09064
PRRC1 proline-rich coiled-coil 1 2.09044
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase 2.08857
HAO2 hydroxyacid oxidase 2 (long chain) 2.08807
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 2.08664
HMGN1 high mobility group nucleosome binding domain 1 2.08448
MEN1 multiple endocrine neoplasia I 2.08347
SLC26A4 solute carrier family 26 (anion exchanger), member 4 2.08079
ZSWIM8 zinc finger, SWIM-type containing 8 2.07845
ARC activity-regulated cytoskeleton-associated protein 2.06202
FAAH fatty acid amide hydrolase 2.05666
PKN2 protein kinase N2 2.05572
GUCA2A guanylate cyclase activator 2A (guanylin) 2.05472
VCL vinculin 2.05354
ZFAND3 zinc finger, AN1-type domain 3 2.04065
INMT indolethylamine N-methyltransferase 2.03885
ARID3C AT rich interactive domain 3C (BRIGHT-like) 2.03099
PRTN3 proteinase 3 2.02339
TMEM18 transmembrane protein 18 2.02271
PDE10A phosphodiesterase 10A 2.02265
CARD10 caspase recruitment domain family, member 10 2.02207
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 2.02193
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae) 2.01956
SFTPA1 surfactant protein A1 2.01681
CDC50A cell division cycle 50 P4-ATPase accessory subunit A 2.01535
ZFP36L1 ZFP36 ring finger protein-like 1 2.01502
NONO non-POU domain containing, octamer-binding 2.01358
MATR3 matrin 3 2.01232
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 2.0123
PATJ PATJ crumbs cell polarity complex component 2.00976
NUP35 nucleoporin 35kDa 2.00919