A2M Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description alpha-2-macroglobulin|Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2)
External Link http://www.ncbi.nlm.nih.gov/gene/2
Similar Terms
Downloads & Tools

Genes

391 interacting proteins for A2M from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
A1BG alpha-1-B glycoprotein
ACP2 acid phosphatase 2, lysosomal
ACTB actin, beta
ADAM19 ADAM metallopeptidase domain 19
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7
ADGRE5 adhesion G protein-coupled receptor E5
ADNP activity-dependent neuroprotector homeobox
AHSG alpha-2-HS-glycoprotein
ALB albumin
ALPP alkaline phosphatase, placental
AMBP alpha-1-microglobulin/bikunin precursor
ANXA6 annexin A6
ANXA7 annexin A7
AP1M2 adaptor-related protein complex 1, mu 2 subunit
APCS amyloid P component, serum
APMAP adipocyte plasma membrane associated protein
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APOA4 apolipoprotein A-IV
APOC1 apolipoprotein C-I
APOC2 apolipoprotein C-II
APOC3 apolipoprotein C-III
APOD apolipoprotein D
APOE apolipoprotein E
APOM apolipoprotein M
APP amyloid beta (A4) precursor protein
ARL8B ADP-ribosylation factor-like 8B
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF7IP activating transcription factor 7 interacting protein
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
AZU1 azurocidin 1
B2M beta-2-microglobulin
BSG basigin (Ok blood group)
BTD biotinidase
BTN2A1 butyrophilin, subfamily 2, member A1
C11ORF58 chromosome 11 open reading frame 58
C18ORF25 chromosome 18 open reading frame 25
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C3 complement component 3
C4A complement component 4A (Rodgers blood group)
C4BPA complement component 4 binding protein, alpha
C4BPB complement component 4 binding protein, beta
C6 complement component 6
C9 complement component 9
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CAPN6 calpain 6
CARM1 coactivator-associated arginine methyltransferase 1
CCNH cyclin H
CCT8 chaperonin containing TCP1, subunit 8 (theta)
CD109 CD109 molecule
CD276 CD276 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD44 CD44 molecule (Indian blood group)
CD5L CD5 molecule-like
CDC37 cell division cycle 37
CDC42 cell division cycle 42
CDK11A cyclin-dependent kinase 11A
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CDK7 cyclin-dependent kinase 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CELA1 chymotrypsin-like elastase family, member 1
CENPE centromere protein E, 312kDa
CFB complement factor B
CFH complement factor H
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CKMT1A creatine kinase, mitochondrial 1A
CLN5 ceroid-lipofuscinosis, neuronal 5
CLPTM1 cleft lip and palate associated transmembrane protein 1
CLU clusterin
COL5A1 collagen, type V, alpha 1
COL6A6 collagen, type VI, alpha 6
COLGALT1 collagen beta(1-O)galactosyltransferase 1
CP ceruloplasmin (ferroxidase)
CPB2 carboxypeptidase B2 (plasma)
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa
CRTAP cartilage associated protein
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSNK2B casein kinase 2, beta polypeptide
CTSB cathepsin B
CTSD cathepsin D
CTSE cathepsin E
CTSG cathepsin G
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
DNA2 DNA replication helicase/nuclease 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNASE2 deoxyribonuclease II, lysosomal
DPP7 dipeptidyl-peptidase 7
DSG1 desmoglein 1
DUOX1 dual oxidase 1
ECE1 endothelin converting enzyme 1
ECSIT ECSIT signalling integrator
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EGLN2 egl-9 family hypoxia-inducible factor 2
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ELAVL3 ELAV like neuron-specific RNA binding protein 3
EMC1 ER membrane protein complex subunit 1
ENO2 enolase 2 (gamma, neuronal)
EPYC epiphycan
ERCC2 excision repair cross-complementation group 2
ERCC3 excision repair cross-complementation group 3
ERCC5 excision repair cross-complementation group 5
ERO1L ERO1-like (S. cerevisiae)
EVI5L ecotropic viral integration site 5-like
EXOSC1 exosome component 1
EYS eyes shut homolog (Drosophila)
F2 coagulation factor II (thrombin)
FARSA phenylalanyl-tRNA synthetase, alpha subunit
FASN fatty acid synthase
FBN1 fibrillin 1
FBXL12 F-box and leucine-rich repeat protein 12
FBXO6 F-box protein 6
FBXW4 F-box and WD repeat domain containing 4
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FKBP10 FK506 binding protein 10, 65 kDa
FKBP9 FK506 binding protein 9, 63 kDa
FLNC filamin C, gamma
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FUS FUS RNA binding protein
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase)
GAA glucosidase, alpha; acid
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GBA glucosidase, beta, acid
GC group-specific component (vitamin D binding protein)
GCC2 GRIP and coiled-coil domain containing 2
GCDH glutaryl-CoA dehydrogenase
GEM GTP binding protein overexpressed in skeletal muscle
GLB1 galactosidase, beta 1
GLMP glycosylated lysosomal membrane protein
GNS glucosamine (N-acetyl)-6-sulfatase
GOLGA4 golgin A4
GRB2 growth factor receptor-bound protein 2
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa
GTF2H2 general transcription factor IIH, polypeptide 2, 44kDa
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa
GTF2H5 general transcription factor IIH, polypeptide 5
GUSB glucuronidase, beta
H2AFX H2A histone family, member X
HAX1 HCLS1 associated protein X-1
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HEXA hexosaminidase A (alpha polypeptide)
HIPK1 homeodomain interacting protein kinase 1
HIST1H1D histone cluster 1, H1d
HKR1 HKR1, GLI-Kruppel zinc finger family member
HMOX2 heme oxygenase 2
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HNRNPCL1 heterogeneous nuclear ribonucleoprotein C-like 1
HNRNPK heterogeneous nuclear ribonucleoprotein K
HNRNPL heterogeneous nuclear ribonucleoprotein L
HNRNPR heterogeneous nuclear ribonucleoprotein R
HP haptoglobin
HPR haptoglobin-related protein
HRG histidine-rich glycoprotein
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HYOU1 hypoxia up-regulated 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IGF2R insulin-like growth factor 2 receptor
IGFALS insulin-like growth factor binding protein, acid labile subunit
IGHG2 immunoglobulin heavy constant gamma 2 (G2m marker)
IGLC2 immunoglobulin lambda constant 2 (Kern-Oz- marker)
IGLL5 immunoglobulin lambda-like polypeptide 5
IGSF8 immunoglobulin superfamily, member 8
IL10 interleukin 10
IL1B interleukin 1, beta
IL4 interleukin 4
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITIH1 inter-alpha-trypsin inhibitor heavy chain 1
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4
KIAA0753 KIAA0753
KIRREL kin of IRRE like (Drosophila)
KLC1 kinesin light chain 1
KLK13 kallikrein-related peptidase 13
KLK2 kallikrein-related peptidase 2
KLK3 kallikrein-related peptidase 3
KLK5 kallikrein-related peptidase 5
KNG1 kininogen 1
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KPNB1 karyopherin (importin) beta 1
KRT5 keratin 5, type II
KRT6C keratin 6C, type II
L1CAM L1 cell adhesion molecule
LAMA5 laminin, alpha 5
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAMP1 lysosomal-associated membrane protein 1
LAMP2 lysosomal-associated membrane protein 2
LBP lipopolysaccharide binding protein
LCAT lecithin-cholesterol acyltransferase
LEP leptin
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LNPEP leucyl/cystinyl aminopeptidase
LONP1 lon peptidase 1, mitochondrial
LRP1 low density lipoprotein receptor-related protein 1
LUM lumican
LYZ lysozyme
M6PR mannose-6-phosphate receptor (cation dependent)
MAN2B1 mannosidase, alpha, class 2B, member 1
MAOA monoamine oxidase A
MAP1A microtubule-associated protein 1A
MAPK6 mitogen-activated protein kinase 6
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MARCKS myristoylated alanine-rich protein kinase C substrate
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
MAST1 microtubule associated serine/threonine kinase 1
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae)
MMP2 matrix metallopeptidase 2
MNAT1 MNAT CDK-activating kinase assembly factor 1
MPO myeloperoxidase
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NCDN neurochondrin
NCEH1 neutral cholesterol ester hydrolase 1
NCSTN nicastrin
NEURL4 neuralized E3 ubiquitin protein ligase 4
NGF nerve growth factor (beta polypeptide)
NOMO1 NODAL modulator 1
NONO non-POU domain containing, octamer-binding
NOP58 NOP58 ribonucleoprotein
NOS3 nitric oxide synthase 3 (endothelial cell)
NPC1 Niemann-Pick disease, type C1
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21
NUP210 nucleoporin 210kDa
OPTN optineurin
ORM2 orosomucoid 2
P3H1 prolyl 3-hydroxylase 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAEP progestagen-associated endometrial protein
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PCYOX1 prenylcysteine oxidase 1
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PIGR polymeric immunoglobulin receptor
PIGS phosphatidylinositol glycan anchor biosynthesis, class S
PIGT phosphatidylinositol glycan anchor biosynthesis, class T
PLA2G15 phospholipase A2, group XV
PLG plasminogen
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
PLS3 plastin 3
PLXNB2 plexin B2
PODXL2 podocalyxin-like 2
PON1 paraoxonase 1
PON3 paraoxonase 3
PPT1 palmitoyl-protein thioesterase 1
PRAM1 PML-RARA regulated adaptor molecule 1
PRDX2 peroxiredoxin 2
PROS1 protein S (alpha)
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
PRTN3 proteinase 3
PSAP prosaposin
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
RAB3A RAB3A, member RAS oncogene family
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAD23A RAD23 homolog A (S. cerevisiae)
RAP1B RAP1B, member of RAS oncogene family
RBM25 RNA binding motif protein 25
RETN resistin
RHEB Ras homolog enriched in brain
RHOA ras homolog family member A
RHOB ras homolog family member B
RHOBTB1 Rho-related BTB domain containing 1
RHOBTB2 Rho-related BTB domain containing 2
RHOC ras homolog family member C
RHOD ras homolog family member D
RHOF ras homolog family member F (in filopodia)
RHOG ras homolog family member G
RHOH ras homolog family member H
RHOJ ras homolog family member J
RHOQ ras homolog family member Q
RHOT1 ras homolog family member T1
RHOT2 ras homolog family member T2
RHOU ras homolog family member U
RHOV ras homolog family member V
RNF32 ring finger protein 32
RPL12 ribosomal protein L12
RPL13A ribosomal protein L13a
RPL24 ribosomal protein L24
RPL3 ribosomal protein L3
RPLP0 ribosomal protein, large, P0
RPP14 ribonuclease P/MRP 14kDa subunit
RPSA ribosomal protein SA
S1PR5 sphingosine-1-phosphate receptor 5
SAA2 serum amyloid A2
SAA4 serum amyloid A4, constitutive
SACS sacsin molecular chaperone
SAFB scaffold attachment factor B
SCARB1 scavenger receptor class B, member 1
SCARB2 scavenger receptor class B, member 2
SEC24C SEC24 family member C
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEPT8 septin 8
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SETD3 SET domain containing 3
SGSH N-sulfoglucosamine sulfohydrolase
SHBG sex hormone-binding globulin
SIAE sialic acid acetylesterase
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SMN2 survival of motor neuron 2, centromeric
SNRPA small nuclear ribonucleoprotein polypeptide A
SPACA3 sperm acrosome associated 3
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SSR1 signal sequence receptor, alpha
STAMBPL1 STAM binding protein-like 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STOM stomatin
STS steroid sulfatase (microsomal), isozyme S
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic)
SUMF1 sulfatase modifying factor 1
SUN2 Sad1 and UNC84 domain containing 2
SWSAP1 SWIM-type zinc finger 7 associated protein 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TFRC transferrin receptor
TGFBI transforming growth factor, beta-induced, 68kDa
TGIF1 TGFB-induced factor homeobox 1
TGM2 transglutaminase 2
TK1 thymidine kinase 1, soluble
TMX3 thioredoxin-related transmembrane protein 3
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TP63 tumor protein p63
TPBG trophoblast glycoprotein
TPP1 tripeptidyl peptidase I
TRAPPC5 trafficking protein particle complex 5
TREML2 triggering receptor expressed on myeloid cells-like 2
TRIM33 tripartite motif containing 33
TSC22D1 TSC22 domain family, member 1
TSPEAR thrombospondin-type laminin G domain and EAR repeats
TTR transthyretin
TUBA1B tubulin, alpha 1b
TUBA1C tubulin, alpha 1c
TUBB tubulin, beta class I
TUBB4A tubulin, beta 4A class IVa
TXNDC15 thioredoxin domain containing 15
TYRO3 TYRO3 protein tyrosine kinase
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats
UBE2L3 ubiquitin-conjugating enzyme E2L 3
UFD1L ubiquitin fusion degradation 1 like (yeast)
UMPS uridine monophosphate synthetase
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)
VCP valosin containing protein
VDAC1 voltage-dependent anion channel 1
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae)
VTN vitronectin
ZBTB4 zinc finger and BTB domain containing 4
ZFP14 ZFP14 zinc finger protein
ZNF267 zinc finger protein 267
ZNF33A zinc finger protein 33A
ZNF460 zinc finger protein 460
ZNF510 zinc finger protein 510
ZNF676 zinc finger protein 676