A549 Gene Set

Dataset COSMIC Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description Human lung carcinoma established from an explanted lung tumor which was removed from a 58-year-old Caucasian man in 1972; cells were described to induce tumors in athymic mice and to synthesize lecithin. (BRENDA Tissue and Enzyme Source Ontology, BTO_0000018)
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Genes

430 genes mutated in the A549 cell line from the COSMIC Cell Line Gene Mutation Profiles dataset.

Symbol Name
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2
ABI3BP ABI family, member 3 (NESH) binding protein
ACTN1 actinin, alpha 1
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7
ADAMTSL2 ADAMTS-like 2
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide
AGO2 argonaute RISC catalytic component 2
AGTR1 angiotensin II receptor, type 1
AHNAK2 AHNAK nucleoprotein 2
AIM1 absent in melanoma 1
ALS2CL ALS2 C-terminal like
ANKIB1 ankyrin repeat and IBR domain containing 1
ANKRD36 ankyrin repeat domain 36
ANKZF1 ankyrin repeat and zinc finger domain containing 1
APOB apolipoprotein B
ARHGAP25 Rho GTPase activating protein 25
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ARMC1 armadillo repeat containing 1
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ARSH arylsulfatase family, member H
ARSI arylsulfatase family, member I
AS3MT arsenite methyltransferase
ASB5 ankyrin repeat and SOCS box containing 5
ATG13 autophagy related 13
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
ATR ATR serine/threonine kinase
BBS2 Bardet-Biedl syndrome 2
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BMS1 BMS1 ribosome biogenesis factor
BPIFA1 BPI fold containing family A, member 1
BRD1 bromodomain containing 1
BTBD11 BTB (POZ) domain containing 11
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CADM3 cell adhesion molecule 3
CAGE1 cancer antigen 1
CANX calnexin
CAPN7 calpain 7
CARD11 caspase recruitment domain family, member 11
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CC2D1B coiled-coil and C2 domain containing 1B
CC2D2A coiled-coil and C2 domain containing 2A
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCDC129 coiled-coil domain containing 129
CCDC80 coiled-coil domain containing 80
CD2AP CD2-associated protein
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CHD3 chromodomain helicase DNA binding protein 3
CHD7 chromodomain helicase DNA binding protein 7
CHRDL2 chordin-like 2
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal)
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CIAO1 cytosolic iron-sulfur assembly component 1
CKAP5 cytoskeleton associated protein 5
CLCN7 chloride channel, voltage-sensitive 7
CLCNKB chloride channel, voltage-sensitive Kb
CLEC16A C-type lectin domain family 16, member A
CLIP2 CAP-GLY domain containing linker protein 2
CNPPD1 cyclin Pas1/PHO80 domain containing 1
CNTLN centlein, centrosomal protein
COL11A2 collagen, type XI, alpha 2
COL21A1 collagen, type XXI, alpha 1
COL26A1 collagen, type XXVI, alpha 1
COL4A6 collagen, type IV, alpha 6
COL6A3 collagen, type VI, alpha 3
CPNE6 copine VI (neuronal)
CPPED1 calcineurin-like phosphoesterase domain containing 1
CSMD1 CUB and Sushi multiple domains 1
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNND2 catenin (cadherin-associated protein), delta 2
CUL2 cullin 2
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1
DACT1 dishevelled-binding antagonist of beta-catenin 1
DCAF5 DDB1 and CUL4 associated factor 5
DCAF6 DDB1 and CUL4 associated factor 6
DCLK3 doublecortin-like kinase 3
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
DGKE diacylglycerol kinase, epsilon 64kDa
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58
DLG2 discs, large homolog 2 (Drosophila)
DMGDH dimethylglycine dehydrogenase
DNAAF3 dynein, axonemal, assembly factor 3
DNAH3 dynein, axonemal, heavy chain 3
DNAH8 dynein, axonemal, heavy chain 8
DPP8 dipeptidyl-peptidase 8
DPY19L4 dpy-19-like 4 (C. elegans)
DTNB dystrobrevin, beta
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
EGLN1 egl-9 family hypoxia-inducible factor 1
EHD1 EH-domain containing 1
ELL2 elongation factor, RNA polymerase II, 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPHA1 EPH receptor A1
ERC1 ELKS/RAB6-interacting/CAST family member 1
F12 coagulation factor XII (Hageman factor)
FAM160B2 family with sequence similarity 160, member B2
FAM161A family with sequence similarity 161, member A
FAM171A2 family with sequence similarity 171, member A2
FAM175B family with sequence similarity 175, member B
FAM47C family with sequence similarity 47, member C
FAM63A family with sequence similarity 63, member A
FAM63B family with sequence similarity 63, member B
FBXL2 F-box and leucine-rich repeat protein 2
FBXO48 F-box protein 48
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCHSD2 FCH and double SH3 domains 2
FCRL2 Fc receptor-like 2
FGD1 FYVE, RhoGEF and PH domain containing 1
FGFBP2 fibroblast growth factor binding protein 2
FGGY FGGY carbohydrate kinase domain containing
FGL1 fibrinogen-like 1
FH fumarate hydratase
FLNC filamin C, gamma
FLT3 fms-related tyrosine kinase 3
FLVCR1 feline leukemia virus subgroup C cellular receptor 1
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
FMN1 formin 1
FOXN3 forkhead box N3
FRAS1 Fraser extracellular matrix complex subunit 1
FRMD6 FERM domain containing 6
FSCN1 fascin actin-bundling protein 1
FSTL5 follistatin-like 5
FUCA2 fucosidase, alpha-L- 2, plasma
FUS FUS RNA binding protein
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GAS2L3 growth arrest-specific 2 like 3
GDF15 growth differentiation factor 15
GIMAP1 GTPase, IMAP family member 1
GLB1L3 galactosidase, beta 1-like 3
GLE1 GLE1 RNA export mediator
GOLGA4 golgin A4
GPATCH11 G patch domain containing 11
GPR137 G protein-coupled receptor 137
GPR137C G protein-coupled receptor 137C
GPR85 G protein-coupled receptor 85
GRHL1 grainyhead-like 1 (Drosophila)
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRIA4 glutamate receptor, ionotropic, AMPA 4
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRM7 glutamate receptor, metabotropic 7
GTSE1 G-2 and S-phase expressed 1
HCLS1 hematopoietic cell-specific Lyn substrate 1
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
HFM1 HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
HIP1 huntingtin interacting protein 1
HIP1R huntingtin interacting protein 1 related
HIPK3 homeodomain interacting protein kinase 3
HIST1H2AJ histone cluster 1, H2aj
HLA-DOB major histocompatibility complex, class II, DO beta
HMCN1 hemicentin 1
HMGN5 high mobility group nucleosome binding domain 5
HOOK1 hook microtubule-tethering protein 1
HS6ST2 heparan sulfate 6-O-sulfotransferase 2
HS6ST3 heparan sulfate 6-O-sulfotransferase 3
HYDIN HYDIN, axonemal central pair apparatus protein
IFIH1 interferon induced with helicase C domain 1
IGFALS insulin-like growth factor binding protein, acid labile subunit
IGSF1 immunoglobulin superfamily, member 1
IKZF3 IKAROS family zinc finger 3 (Aiolos)
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
ITGA11 integrin, alpha 11
ITPKC inositol-trisphosphate 3-kinase C
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JAKMIP2 janus kinase and microtubule interacting protein 2
JPH1 junctophilin 1
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2
KEAP1 kelch-like ECH-associated protein 1
KIAA0100 KIAA0100
KIAA0226L KIAA0226-like
KIAA1467 KIAA1467
KIAA1549 KIAA1549
KIAA1671 KIAA1671
KIF13A kinesin family member 13A
KIF26A kinesin family member 26A
KIRREL3 kin of IRRE like 3 (Drosophila)
KLHL20 kelch-like family member 20
KLK13 kallikrein-related peptidase 13
KLK9 kallikrein-related peptidase 9
KNTC1 kinetochore associated 1
KRAS Kirsten rat sarcoma viral oncogene homolog
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LCT lactase
LHCGR luteinizing hormone/choriogonadotropin receptor
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LMBRD2 LMBR1 domain containing 2
LMTK1 lemur tail kinase 1
LRP1 low density lipoprotein receptor-related protein 1
LRP2 low density lipoprotein receptor-related protein 2
LRRC16A leucine rich repeat containing 16A
LRRIQ1 leucine-rich repeats and IQ motif containing 1
MAG myelin associated glycoprotein
MAGEA11 melanoma antigen family A11
MAGEB10 melanoma antigen family B10
MAGEB16 melanoma antigen family B16
MAGEC1 melanoma antigen family C1
MAP3K19 mitogen-activated protein kinase kinase kinase 19
MATN2 matrilin 2
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MCM8 minichromosome maintenance complex component 8
MDH1B malate dehydrogenase 1B, NAD (soluble)
MECP2 methyl CpG binding protein 2
MEGF10 multiple EGF-like-domains 10
METTL8 methyltransferase like 8
MFN2 mitofusin 2
MGAM maltase-glucoamylase
MIB1 mindbomb E3 ubiquitin protein ligase 1
MINK1 misshapen-like kinase 1
MKI67 marker of proliferation Ki-67
MOGAT3 monoacylglycerol O-acyltransferase 3
MON1A MON1 secretory trafficking family member A
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
MRGPRX2 MAS-related GPR, member X2
MTBP MDM2 binding protein
MTFR1L mitochondrial fission regulator 1-like
MTUS2 microtubule associated tumor suppressor candidate 2
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MUC5B mucin 5B, oligomeric mucus/gel-forming
MXRA5 matrix-remodelling associated 5
MYCBPAP MYCBP associated protein
MYH2 myosin, heavy chain 2, skeletal muscle, adult
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic
MYO18A myosin XVIIIA
MYO18B myosin XVIIIB
N4BP3 NEDD4 binding protein 3
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NAMPT nicotinamide phosphoribosyltransferase
NCOR1 nuclear receptor corepressor 1
NDC80 NDC80 kinetochore complex component
NEB nebulin
NEBL nebulette
NES nestin
NIFK nucleolar protein interacting with the FHA domain of MKI67
NIPBL Nipped-B homolog (Drosophila)
NLGN4X neuroligin 4, X-linked
NMNAT1 nicotinamide nucleotide adenylyltransferase 1
NPFFR2 neuropeptide FF receptor 2
NRSN2 neurensin 2
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
NUP210 nucleoporin 210kDa
NXPE2 neurexophilin and PC-esterase domain family, member 2
OR10S1 olfactory receptor, family 10, subfamily S, member 1
OR4M2 olfactory receptor, family 4, subfamily M, member 2
OR4N2 olfactory receptor, family 4, subfamily N, member 2
OR51G2 olfactory receptor, family 51, subfamily G, member 2
OR52H1 olfactory receptor, family 52, subfamily H, member 1
OR56A3 olfactory receptor, family 56, subfamily A, member 3
OR5B17 olfactory receptor, family 5, subfamily B, member 17
OR5M3 olfactory receptor, family 5, subfamily M, member 3
OSBP oxysterol binding protein
OTOP1 otopetrin 1
PADI1 peptidyl arginine deiminase, type I
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7
PCBP3 poly(rC) binding protein 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCNX pecanex homolog (Drosophila)
PCSK5 proprotein convertase subtilisin/kexin type 5
PCSK7 proprotein convertase subtilisin/kexin type 7
PDE4D phosphodiesterase 4D, cAMP-specific
PDGFRL platelet-derived growth factor receptor-like
PEAK1 pseudopodium-enriched atypical kinase 1
PELP1 proline, glutamate and leucine rich protein 1
PGBD5 piggyBac transposable element derived 5
PHACTR3 phosphatase and actin regulator 3
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PHKA2 phosphorylase kinase, alpha 2 (liver)
PHRF1 PHD and ring finger domains 1
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PIAS2 protein inhibitor of activated STAT, 2
PKD1L2 polycystic kidney disease 1-like 2 (gene/pseudogene)
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1
PLBD1 phospholipase B domain containing 1
PLCH1 phospholipase C, eta 1
PLEK2 pleckstrin 2
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
PLEKHH3 pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
PLSCR2 phospholipid scramblase 2
PMPCB peptidase (mitochondrial processing) beta
PNPLA5 patatin-like phospholipase domain containing 5
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLR3B polymerase (RNA) III (DNA directed) polypeptide B
POM121L12 POM121 transmembrane nucleoporin-like 12
POMZP3 POM121 and ZP3 fusion
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
POU5F1B POU class 5 homeobox 1B
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PPP5C protein phosphatase 5, catalytic subunit
PRIM2 primase, DNA, polypeptide 2 (58kDa)
PRUNE2 prune homolog 2 (Drosophila)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PVRL3 poliovirus receptor-related 3
PYCRL pyrroline-5-carboxylate reductase-like
PZP pregnancy-zone protein
QRFPR pyroglutamylated RFamide peptide receptor
QRICH2 glutamine rich 2
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic)
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RALYL RALY RNA binding protein-like
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
RASSF3 Ras association (RalGDS/AF-6) domain family member 3
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RBM12B RNA binding motif protein 12B
RBM24 RNA binding motif protein 24
RGPD3 RANBP2-like and GRIP domain containing 3
RNF133 ring finger protein 133
RNF165 ring finger protein 165
RNGTT RNA guanylyltransferase and 5'-phosphatase
RP1L1 retinitis pigmentosa 1-like 1
RPL3 ribosomal protein L3
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RTTN rotatin
RYR1 ryanodine receptor 1 (skeletal)
SAMD9 sterile alpha motif domain containing 9
SBF2 SET binding factor 2
SCN4A sodium channel, voltage gated, type IV alpha subunit
SCN9A sodium channel, voltage gated, type IX alpha subunit
SDAD1 SDA1 domain containing 1
SDK1 sidekick cell adhesion molecule 1
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SF3B3 splicing factor 3b, subunit 3, 130kDa
SH3GL2 SH3-domain GRB2-like 2
SH3RF2 SH3 domain containing ring finger 2
SIPA1 signal-induced proliferation-associated 1
SIPA1L2 signal-induced proliferation-associated 1 like 2
SLC27A1 solute carrier family 27 (fatty acid transporter), member 1
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13
SLC30A10 solute carrier family 30, member 10
SLC30A8 solute carrier family 30 (zinc transporter), member 8
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLIT1 slit homolog 1 (Drosophila)
SLIT2 slit homolog 2 (Drosophila)
SLITRK4 SLIT and NTRK-like family, member 4
SLITRK6 SLIT and NTRK-like family, member 6
SLX4 SLX4 structure-specific endonuclease subunit
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMYD2 SET and MYND domain containing 2
SNX14 sorting nexin 14
SPAG9 sperm associated antigen 9
SPATA13 spermatogenesis associated 13
SPATA31D1 SPATA31 subfamily D, member 1
SPATA31D4 SPATA31 subfamily D, member 4
SPATA5 spermatogenesis associated 5
SPTBN2 spectrin, beta, non-erythrocytic 2
SRCIN1 SRC kinase signaling inhibitor 1
STARD9 StAR-related lipid transfer (START) domain containing 9
STK11 serine/threonine kinase 11
STK32A serine/threonine kinase 32A
STXBP5 syntaxin binding protein 5 (tomosyn)
STXBP5L syntaxin binding protein 5-like
SUFU suppressor of fused homolog (Drosophila)
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae)
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae)
SYNE1 spectrin repeat containing, nuclear envelope 1
TAAR5 trace amine associated receptor 5
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TAS2R1 taste receptor, type 2, member 1
TBC1D23 TBC1 domain family, member 23
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCEA2 transcription elongation factor A (SII), 2
TCEA3 transcription elongation factor A (SII), 3
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TCHP trichoplein, keratin filament binding
TCTE1 t-complex-associated-testis-expressed 1
TDRD12 tudor domain containing 12
TENM1 teneurin transmembrane protein 1
TFIP11 tuftelin interacting protein 11
THNSL2 threonine synthase-like 2 (S. cerevisiae)
THOP1 thimet oligopeptidase 1
TIAM2 T-cell lymphoma invasion and metastasis 2
TJP1 tight junction protein 1
TMC2 transmembrane channel-like 2
TMC7 transmembrane channel-like 7
TMEM63A transmembrane protein 63A
TNC tenascin C
TNN tenascin N
TNR tenascin R
TNRC6C trinucleotide repeat containing 6C
TNS3 tensin 3
TP53BP1 tumor protein p53 binding protein 1
TRDN triadin
TRIM65 tripartite motif containing 65
TRIP11 thyroid hormone receptor interactor 11
TRO trophinin
TRPM1 transient receptor potential cation channel, subfamily M, member 1
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TRPV5 transient receptor potential cation channel, subfamily V, member 5
TRUB1 TruB pseudouridine (psi) synthase family member 1
TSHZ3 teashirt zinc finger homeobox 3
TTC28 tetratricopeptide repeat domain 28
TTN titin
UNC13C unc-13 homolog C (C. elegans)
UNC5D unc-5 homolog D (C. elegans)
USH1C Usher syndrome 1C (autosomal recessive, severe)
USP10 ubiquitin specific peptidase 10
USP34 ubiquitin specific peptidase 34
USP41 ubiquitin specific peptidase 41
USP6 ubiquitin specific peptidase 6
UVSSA UV-stimulated scaffold protein A
VARS2 valyl-tRNA synthetase 2, mitochondrial
VCL vinculin
WAPAL wings apart-like homolog (Drosophila)
XIRP2 xin actin binding repeat containing 2
ZBTB17 zinc finger and BTB domain containing 17
ZBTB4 zinc finger and BTB domain containing 4
ZCWPW2 zinc finger, CW type with PWWP domain 2
ZFHX3 zinc finger homeobox 3
ZFPM2 zinc finger protein, FOG family member 2
ZFYVE27 zinc finger, FYVE domain containing 27
ZNF135 zinc finger protein 135
ZNF14 zinc finger protein 14
ZNF215 zinc finger protein 215
ZNF22 zinc finger protein 22
ZNF354B zinc finger protein 354B
ZNF385A zinc finger protein 385A
ZNF425 zinc finger protein 425
ZNF654 zinc finger protein 654
ZNF729 zinc finger protein 729
ZNF737 zinc finger protein 737
ZNF749 zinc finger protein 749
ZNF766 zinc finger protein 766
ZSCAN29 zinc finger and SCAN domain containing 29