A549_Alendronate sodium trihydrate_10µM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description Alendronate sodium trihydrate 10µM perturbation in A549 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the A549_Alendronate sodium trihydrate_10µM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
PKM pyruvate kinase, muscle 0.269582
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.237308
CA12 carbonic anhydrase XII 0.218829
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.190168
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.115967
ASPH aspartate beta-hydroxylase 0.111916
FTL ferritin, light polypeptide 0.105633
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.097597
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0902476
GPX2 glutathione peroxidase 2 0.0859511
PRKCA protein kinase C, alpha 0.0789464
PDLIM5 PDZ and LIM domain 5 0.0768599
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0768483
AKR1C1 aldo-keto reductase family 1, member C1 0.0765635
AKAP12 A kinase (PRKA) anchor protein 12 0.0714831
MAP1B microtubule-associated protein 1B 0.0677437
LOC112694756 uncharaterized LOC112694756 0.0612235
IGFBP3 insulin-like growth factor binding protein 3 0.0601016
UBL4A ubiquitin-like 4A 0.0592499
S100A6 S100 calcium binding protein A6 0.0541776
RPLP1 ribosomal protein, large, P1 0.0539976
MYO1E myosin IE 0.0526744
TMSB10 thymosin beta 10 0.050366
NRG1 neuregulin 1 0.0480308
TPI1 triosephosphate isomerase 1 0.0462625
ZFHX3 zinc finger homeobox 3 0.0452517
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0449112
PTMS parathymosin 0.0442295
RPS8 ribosomal protein S8 0.0414704
AKR1C2 aldo-keto reductase family 1, member C2 0.0397975
VIM vimentin 0.0392233
UBE2H ubiquitin-conjugating enzyme E2H 0.0390534
ARL4C ADP-ribosylation factor-like 4C 0.037755
TAOK1 TAO kinase 1 0.0374912
RPLP0 ribosomal protein, large, P0 0.0373634
FAM107B family with sequence similarity 107, member B 0.0373253
PDE10A phosphodiesterase 10A 0.0369557
RPL30 ribosomal protein L30 0.0366922
PGK1 phosphoglycerate kinase 1 0.0363722
RPL15 ribosomal protein L15 0.0362829
RPS6 ribosomal protein S6 0.0354789
KYNU kynureninase 0.0354232
CPLX2 complexin 2 0.0352339
RPS16 ribosomal protein S16 0.0344548
RPS17 ribosomal protein S17 0.031621
RNF217 ring finger protein 217 0.0308433
LRP10 low density lipoprotein receptor-related protein 10 0.0307796
NRIP1 nuclear receptor interacting protein 1 0.029332
TOB1 transducer of ERBB2, 1 0.0290568
ITGB5 integrin, beta 5 0.0288356
RPL13A ribosomal protein L13a 0.0286197
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0286101
ANXA4 annexin A4 0.027789
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0277634
KIF5B kinesin family member 5B 0.0274952
SLC38A1 solute carrier family 38, member 1 0.0273065
HRNR hornerin 0.027119
PSD3 pleckstrin and Sec7 domain containing 3 0.0269786
RPLP2 ribosomal protein, large, P2 0.0265113
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0263646
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0262643
DNM2 dynamin 2 0.0260849
S100A10 S100 calcium binding protein A10 0.0259144
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.0255132
MRPL13 mitochondrial ribosomal protein L13 0.025364
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0250481
CD151 CD151 molecule (Raph blood group) 0.0249069
CCDC88A coiled-coil domain containing 88A 0.0246739
LDHA lactate dehydrogenase A 0.0245311
ANXA2 annexin A2 0.0244743
ESYT2 extended synaptotagmin-like protein 2 0.0241085
ERRFI1 ERBB receptor feedback inhibitor 1 0.0240106
SLC35B4 solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4 0.0234108
ANXA1 annexin A1 0.0233031
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0230714
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0230643
KLF13 Kruppel-like factor 13 0.023002
KRT81 keratin 81, type II 0.0226806
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.022439
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0221943
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0218365
MAML3 mastermind-like 3 (Drosophila) 0.0217664
HILPDA hypoxia inducible lipid droplet-associated 0.0217626
MYO9A myosin IXA 0.0213521
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0213073
AKR1C3 aldo-keto reductase family 1, member C3 0.0211754
PFN1 profilin 1 0.0210444
FNDC3B fibronectin type III domain containing 3B 0.0206672
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0205948
RPL4 ribosomal protein L4 0.0205224
EZR ezrin 0.0204617
MACF1 microtubule-actin crosslinking factor 1 0.0203319
SANBR SANT and BTB domain regulator of CSR 0.0201523
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.0200283
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0198438
APRT adenine phosphoribosyltransferase 0.0198137
SSBP2 single-stranded DNA binding protein 2 0.0196594
SMIM44 small integral membrane protein 44 0.0195938
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0192272
BMP6 bone morphogenetic protein 6 0.0191653
JUP junction plakoglobin 0.0189225
RPS11 ribosomal protein S11 0.018896
NTN4 netrin 4 0.0188604
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0185639
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0184676
EDF1 endothelial differentiation-related factor 1 0.0184648
DCAF6 DDB1 and CUL4 associated factor 6 0.0184423
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) 0.0184389
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0184163
EPN2 epsin 2 0.0183638
MUSK muscle, skeletal, receptor tyrosine kinase 0.0183039
TAOK3 TAO kinase 3 0.018288
DNMBP dynamin binding protein 0.018286
RPS4X ribosomal protein S4, X-linked 0.018132
DHCR7 7-dehydrocholesterol reductase 0.018125
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0181105
RPL12 ribosomal protein L12 0.0180809
RHOB ras homolog family member B 0.018048
DSPP dentin sialophosphoprotein 0.018036
UTRN utrophin 0.017985
PYGB phosphorylase, glycogen; brain 0.0179485
DYM dymeclin 0.0178109
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.0178077
EREG epiregulin 0.0175967
DARS1 aspartyl-tRNA synthetase 1 0.0175714
BICDL1 BICD family like cargo adaptor 1 0.0173823
BASP1 brain abundant, membrane attached signal protein 1 0.0173693
NFIB nuclear factor I/B 0.01734
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0173134
LASP1 LIM and SH3 protein 1 0.0173057
ADGRG6 adhesion G protein-coupled receptor G6 0.0172784
SLC39A6 solute carrier family 39 (zinc transporter), member 6 0.0172016
ITPRIPL2 inositol 1,4,5-trisphosphate receptor interacting protein-like 2 0.0170774
SMIM14 small integral membrane protein 14 0.0170677
C19ORF33 chromosome 19 open reading frame 33 0.0170274
RHOBTB1 Rho-related BTB domain containing 1 0.0169401
GSK3B glycogen synthase kinase 3 beta 0.0168603
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.0168494
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.0168104
DMXL2 Dmx-like 2 0.0167986
THSD4 thrombospondin, type I, domain containing 4 0.0167383
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0165894
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0164759
ABHD12 abhydrolase domain containing 12 0.0164551
HSPB1 heat shock 27kDa protein 1 0.0163055
RPL6 ribosomal protein L6 0.0162965
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0160289
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0159933
IER5L immediate early response 5-like 0.0159677
CXCL5 chemokine (C-X-C motif) ligand 5 0.0158131
SERBP1 SERPINE1 mRNA binding protein 1 0.0156859
ITM2B integral membrane protein 2B 0.0156832
C1RL complement component 1, r subcomponent-like 0.0156795
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 0.0155921
PARK7 parkinson protein 7 0.0155714
MRPS34 mitochondrial ribosomal protein S34 0.0155086
DUSP16 dual specificity phosphatase 16 0.015499
ARRDC3 arrestin domain containing 3 0.0154518
ENOSF1 enolase superfamily member 1 0.0154145
TBC1D4 TBC1 domain family, member 4 0.0153953
RPL18A ribosomal protein L18a 0.0153803
CST3 cystatin C 0.0153174
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G 0.0152874
ITSN2 intersectin 2 0.0152112
VASP vasodilator-stimulated phosphoprotein 0.0150741
CYTH2 cytohesin 2 0.0150715
RAB3B RAB3B, member RAS oncogene family 0.0150197
AK1 adenylate kinase 1 0.0149896
CTSL cathepsin L 0.0149788
RAI14 retinoic acid induced 14 0.0148688
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0148248
SLK STE20-like kinase 0.0147963
CLIC1 chloride intracellular channel 1 0.0146676
RPL5 ribosomal protein L5 0.0146674
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0146488
MAP2K5 mitogen-activated protein kinase kinase 5 0.0146277
CENPB centromere protein B, 80kDa 0.0146199
RPL8 ribosomal protein L8 0.0146057
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0145726
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0145674
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.0145241
MAP2K1 mitogen-activated protein kinase kinase 1 0.0145212
PRKX protein kinase, X-linked 0.0144784
ZFAND6 zinc finger, AN1-type domain 6 0.0144319
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 0.0142626
TPM3 tropomyosin 3 0.0142339
RRBP1 ribosome binding protein 1 0.014205
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0142012
CTBP2 C-terminal binding protein 2 0.0141899
ANAPC5 anaphase promoting complex subunit 5 0.0141626
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 0.0141493
KIF16B kinesin family member 16B 0.0141485
ACTN4 actinin, alpha 4 0.0141317
CCT3 chaperonin containing TCP1, subunit 3 (gamma) 0.0140811
RNF139 ring finger protein 139 0.0140671
RAD18 RAD18 E3 ubiquitin protein ligase 0.0140591
CRTAP cartilage associated protein 0.0140359
TPM2 tropomyosin 2 (beta) 0.0139561
ARSD arylsulfatase D 0.0139478
SDC1 syndecan 1 0.0139422
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.01388
USP53 ubiquitin specific peptidase 53 0.0138198
CYB5R3 cytochrome b5 reductase 3 0.0138089
URI1 URI1, prefoldin-like chaperone 0.0137978
CRK v-crk avian sarcoma virus CT10 oncogene homolog 0.013756
CBX5 chromobox homolog 5 0.0137152
TNNT1 troponin T type 1 (skeletal, slow) 0.0136878
BBX bobby sox homolog (Drosophila) 0.0136602
GLRX glutaredoxin (thioltransferase) 0.013588
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.013582
PGM2L1 phosphoglucomutase 2-like 1 0.013554
CLASP2 cytoplasmic linker associated protein 2 0.0135314
CAPNS1 calpain, small subunit 1 0.0135234
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0135165
STXBP1 syntaxin binding protein 1 0.0134933
RPL11 ribosomal protein L11 0.0134897
MSN moesin 0.0134836
YEATS2 YEATS domain containing 2 0.0134192
TMEM39A transmembrane protein 39A 0.0133611
SVIL supervillin 0.0133444
GSTP1 glutathione S-transferase pi 1 0.0132808
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0132609
LPGAT1 lysophosphatidylglycerol acyltransferase 1 0.0132592
CDC50A cell division cycle 50 P4-ATPase accessory subunit A 0.0131957
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0131175
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 0.013111
RHOC ras homolog family member C 0.0130619
DIDO1 death inducer-obliterator 1 0.0130354
BUD23 BUD23 rRNA methyltransferase and ribosome maturation factor 0.0130154
NIPSNAP1 nipsnap homolog 1 (C. elegans) 0.012954
PDE7B phosphodiesterase 7B 0.0129135
KLF6 Kruppel-like factor 6 0.0128897
SKAP2 src kinase associated phosphoprotein 2 0.012888
NCAPG non-SMC condensin I complex, subunit G 0.0128816
RAD21 RAD21 homolog (S. pombe) 0.0128615
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0128588
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.012855
LRP1B low density lipoprotein receptor-related protein 1B 0.0127908
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.0127478
CCDC68 coiled-coil domain containing 68 0.0127045
JOSD2 Josephin domain containing 2 0.0126946
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.0126872
GTF2A2 general transcription factor IIA, 2, 12kDa 0.0126705
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0126686
ALKBH5 AlkB family member 5, RNA demethylase 0.0126499
SENP5 SUMO1/sentrin specific peptidase 5 0.0126068
AXIN1 axin 1 0.0125301
SND1 staphylococcal nuclease and tudor domain containing 1 0.0125266
JAK1 Janus kinase 1 0.0125149
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0125148
PRDM4 PR domain containing 4 0.012487
FHIT fragile histidine triad 0.0124826
FLOT1 flotillin 1 0.0124518
TUBB4B tubulin, beta 4B class IVb 0.0124475
CCDC18 coiled-coil domain containing 18 0.0124419
GLS2 glutaminase 2 (liver, mitochondrial) 0.0124173
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0124085
TNPO3 transportin 3 0.0124043
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0123771
RTN4 reticulon 4 0.0123601
ASXL2 additional sex combs like transcriptional regulator 2 0.0123556
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0123517
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0123037
RPL28 ribosomal protein L28 0.0122993
TUBA1A tubulin, alpha 1a 0.0122819
VGLL4 vestigial-like family member 4 0.0122812
TRIOBP TRIO and F-actin binding protein 0.0122437
EMP3 epithelial membrane protein 3 0.0121715
CAPN1 calpain 1, (mu/I) large subunit 0.0121643
EPS15 epidermal growth factor receptor pathway substrate 15 0.0121433
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 0.012108
CSNK1A1 casein kinase 1, alpha 1 0.0120996
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 0.012085
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 0.0120595
HOMER1 homer scaffolding protein 1 0.0120194
DMTN dematin actin binding protein 0.0120057
FANCB Fanconi anemia, complementation group B 0.011987
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) 0.0119767
RRAS related RAS viral (r-ras) oncogene homolog 0.0119614
DAZAP1 DAZ associated protein 1 0.0119458
NPAS2 neuronal PAS domain protein 2 0.0119402
CNPY3 canopy FGF signaling regulator 3 0.0119263
PAQR5 progestin and adipoQ receptor family member V 0.0119168
AGO3 argonaute RISC catalytic component 3 0.011885
HINT1 histidine triad nucleotide binding protein 1 0.011861
BICD1 bicaudal D homolog 1 (Drosophila) 0.0118563
SYTL2 synaptotagmin-like 2 0.011856
PTMA prothymosin, alpha 0.0118387
ETV4 ets variant 4 0.0118274
SLMAP sarcolemma associated protein 0.0118239
CERT1 ceramide transporter 1 0.0117268
RHOF ras homolog family member F (in filopodia) 0.011725
ADISSP adipose secreted signaling protein 0.0117102
ITSN1 intersectin 1 (SH3 domain protein) 0.0116625
ZC3H13 zinc finger CCCH-type containing 13 0.011648
SEC22C SEC22 vesicle trafficking protein homolog C (S. cerevisiae) 0.0116302
REPS1 RALBP1 associated Eps domain containing 1 0.0116216
NVL nuclear VCP-like 0.0115578
CISD3 CDGSH iron sulfur domain 3 0.0115506
RRP7A ribosomal RNA processing 7 homolog A (S. cerevisiae) 0.0115368
RPS27 ribosomal protein S27 0.0115357
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1 0.0115325
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0115291
ECH1 enoyl CoA hydratase 1, peroxisomal 0.0115228
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 0.0115022
CAMSAP1 calmodulin regulated spectrin-associated protein 1 0.0114965
GAB2 GRB2-associated binding protein 2 0.0114847
EHBP1L1 EH domain binding protein 1-like 1 0.0114608
NHSL1 NHS-like 1 0.0114465
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0114263
ADRM1 adhesion regulating molecule 1 0.0114237
EIF3B eukaryotic translation initiation factor 3, subunit B 0.011408
CDK8 cyclin-dependent kinase 8 0.0113768
TKT transketolase 0.0113548
TSPAN14 tetraspanin 14 0.0113422
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.0113419
BZW1 basic leucine zipper and W2 domains 1 0.0113416
VDAC2 voltage-dependent anion channel 2 0.0113402
PURB purine-rich element binding protein B 0.0113216
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0113198
RC3H1 ring finger and CCCH-type domains 1 0.0113135
LMAN2 lectin, mannose-binding 2 0.0113103
LTO1 LTO1 maturation factor of ABCE1 0.011277
NEBL nebulette 0.0112658
TRIB3 tribbles pseudokinase 3 0.011125
SAMD4B sterile alpha motif domain containing 4B 0.0110754
SCAMP2 secretory carrier membrane protein 2 0.0110569
SOX9 SRY (sex determining region Y)-box 9 0.011051
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0110508
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.0110458
INSL4 insulin-like 4 (placenta) 0.0110231
FILIP1 filamin A interacting protein 1 0.0110209
PFKP phosphofructokinase, platelet 0.0110106
CDR2 cerebellar degeneration-related protein 2, 62kDa 0.010979
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0109709
WWC3 WWC family member 3 0.0109682
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.0109646
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0109635
ABHD15 abhydrolase domain containing 15 0.0109634
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 0.0109466
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 0.0109352
TMEM65 transmembrane protein 65 0.0109295
AK3 adenylate kinase 3 0.0109265
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0109101
REXO2 RNA exonuclease 2 0.0108994
ADAM10 ADAM metallopeptidase domain 10 0.0108927
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0108748
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 0.0108239
PROC protein C (inactivator of coagulation factors Va and VIIIa) 0.0108124
PES1 pescadillo ribosomal biogenesis factor 1 0.0107901
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.0107772
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 0.0107707
HMGB1 high mobility group box 1 0.01077
DENND11 DENN domain containing 11 0.0107632
MTPN myotrophin 0.0107543
UBC ubiquitin C 0.010746
ZFP36L1 ZFP36 ring finger protein-like 1 0.0106232
SYNJ2BP synaptojanin 2 binding protein 0.0105863
MED27 mediator complex subunit 27 0.0105593
PIAS1 protein inhibitor of activated STAT, 1 0.0105534
RPL27 ribosomal protein L27 0.010542
HSDL2 hydroxysteroid dehydrogenase like 2 0.0105378
RAP1GAP2 RAP1 GTPase activating protein 2 0.0105022
CATSPERB catsper channel auxiliary subunit beta 0.0104812
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta 0.0104741
ZNFX1 zinc finger, NFX1-type containing 1 0.0104697
URM1 ubiquitin related modifier 1 0.0104629
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 0.0104429
UBAP2L ubiquitin associated protein 2-like 0.0103798
IQSEC2 IQ motif and Sec7 domain 2 0.0103743
SPATS2L spermatogenesis associated, serine-rich 2-like 0.010312
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0102875
HSPA4 heat shock 70kDa protein 4 0.0102613
DGKD diacylglycerol kinase, delta 130kDa 0.0102596
TCERG1 transcription elongation regulator 1 0.0102535
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) 0.0102524
ANO10 anoctamin 10 0.0102518
UBQLN1 ubiquilin 1 0.0102317
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0102178
GOSR1 golgi SNAP receptor complex member 1 0.0102165
ANGPTL4 angiopoietin-like 4 0.0101987
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0101949
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 0.0101796
NOP53 NOP53 ribosome biogenesis factor 0.0101654
MYADM myeloid-associated differentiation marker 0.0101562
TPT1 tumor protein, translationally-controlled 1 0.0100931
DGKH diacylglycerol kinase, eta 0.01007
UBA1 ubiquitin-like modifier activating enzyme 1 0.010068
IGFBP4 insulin-like growth factor binding protein 4 0.0100468
OSMR oncostatin M receptor 0.0100366
TMEM120B transmembrane protein 120B 0.0100314
CDA cytidine deaminase 0.0100294
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa 0.0100025
IST1 increased sodium tolerance 1 homolog (yeast) 0.00998253
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.00997974
CCNY cyclin Y 0.00997563
SPAG9 sperm associated antigen 9 0.00997456
TOR1AIP2 torsin A interacting protein 2 0.00996608
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.00996545
PCYT1A phosphate cytidylyltransferase 1, choline, alpha 0.0099525
TSC22D1 TSC22 domain family, member 1 0.00995054
RPS21 ribosomal protein S21 0.00993965
RAD23A RAD23 homolog A (S. cerevisiae) 0.00992828
PGPEP1 pyroglutamyl-peptidase I 0.0099051
ADGRE5 adhesion G protein-coupled receptor E5 0.00990236
APAF1 apoptotic peptidase activating factor 1 0.00989209
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.00988714
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.00988539
KDSR 3-ketodihydrosphingosine reductase 0.00987183
TCP1 t-complex 1 0.00986409
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa 0.00985338
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.00983903
KDM5A lysine (K)-specific demethylase 5A 0.00981832
GSPT1 G1 to S phase transition 1 0.00981046
TMEM131 transmembrane protein 131 0.00980997
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.00980813
USP9X ubiquitin specific peptidase 9, X-linked 0.00980102
RHOQ ras homolog family member Q 0.00977868
SPATA17 spermatogenesis associated 17 0.00977063
SBF2 SET binding factor 2 0.00976229
SNX14 sorting nexin 14 0.00974972
SELENOW selenoprotein W 0.00974531
SCARB1 scavenger receptor class B, member 1 0.00973803
AASDH aminoadipate-semialdehyde dehydrogenase 0.00972799
COQ8B coenzyme Q8B 0.00969394
MAST2 microtubule associated serine/threonine kinase 2 0.00969208
CEP170 centrosomal protein 170kDa 0.00968855
ITGB4 integrin, beta 4 0.00966804
PRKCI protein kinase C, iota 0.00966195
GANC glucosidase, alpha; neutral C 0.00965188
UQCRC2 ubiquinol-cytochrome c reductase core protein II 0.00959492
POLD2 polymerase (DNA directed), delta 2, accessory subunit 0.00957781
RASAL2 RAS protein activator like 2 0.0095676
CCNT1 cyclin T1 0.0095627
TGFB1 transforming growth factor, beta 1 0.00954279
RYBP RING1 and YY1 binding protein 0.00953408
PHF20 PHD finger protein 20 0.00952949
MAN1A2 mannosidase, alpha, class 1A, member 2 0.0095253
MRPS21 mitochondrial ribosomal protein S21 0.00951486
FAM219A family with sequence similarity 219, member A 0.00950732
TXNDC11 thioredoxin domain containing 11 0.00950433
MANSC1 MANSC domain containing 1 0.00949598
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 0.0094902
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit 0.00948906
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 0.00947742
PNRC1 proline-rich nuclear receptor coactivator 1 0.0094689
EML1 echinoderm microtubule associated protein like 1 0.00946315
SLA2 Src-like-adaptor 2 0.00945328
HLA-A major histocompatibility complex, class I, A 0.00944842
RPL37A ribosomal protein L37a 0.00942883
ADD1 adducin 1 (alpha) 0.00942603
SSRP1 structure specific recognition protein 1 0.00942027
SH3PXD2A SH3 and PX domains 2A 0.00940895
CHUK conserved helix-loop-helix ubiquitous kinase 0.00940853
AFTPH aftiphilin 0.00939638
SH3KBP1 SH3-domain kinase binding protein 1 0.0093832
RABL6 RAB, member RAS oncogene family-like 6 0.00938126
DEK DEK proto-oncogene 0.0093766
MORC4 MORC family CW-type zinc finger 4 0.0093701
IPO5 importin 5 0.00935331
RDX radixin 0.0093414
SCO1 SCO1 cytochrome c oxidase assembly protein 0.00933999
PVR poliovirus receptor 0.00933749
SERP1 stress-associated endoplasmic reticulum protein 1 0.00933263
FMNL2 formin-like 2 0.00933149
RUNX1 runt-related transcription factor 1 0.00932722
SKP1 S-phase kinase-associated protein 1 0.00932682
FBXL5 F-box and leucine-rich repeat protein 5 0.0093164
PSENEN presenilin enhancer gamma secretase subunit 0.00930416
MOB1A MOB kinase activator 1A 0.00929093
DUT deoxyuridine triphosphatase 0.00929014
BZW2 basic leucine zipper and W2 domains 2 0.00928825
GNB5 guanine nucleotide binding protein (G protein), beta 5 0.00928662
ITGA6 integrin, alpha 6 0.00928096
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 0.00927514
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.00926416
HEBP2 heme binding protein 2 0.00924722
ERP29 endoplasmic reticulum protein 29 0.00923678
TPD52 tumor protein D52 0.00922788
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 0.00920084
USP11 ubiquitin specific peptidase 11 0.00919063
PNISR PNN-interacting serine/arginine-rich protein 0.00918414
SCAF1 SR-related CTD-associated factor 1 0.00918136
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.00917172
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 0.00916475
TSSC4 tumor suppressing subtransferable candidate 4 0.00916266
ANXA5 annexin A5 0.00911409
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.00910436
ZNF586 zinc finger protein 586 0.00908909
DIS3L2 DIS3 like 3'-5' exoribonuclease 2 0.00907307
CARMIL1 capping protein regulator and myosin 1 linker 1 0.0090664
KDM4B lysine (K)-specific demethylase 4B 0.00902647
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 0.00902172
FAM199X family with sequence similarity 199, X-linked 0.00901071
MBNL1 muscleblind-like splicing regulator 1 0.00900036
CNKSR2 connector enhancer of kinase suppressor of Ras 2 0.00899274
LDB2 LIM domain binding 2 0.00896237
SNX6 sorting nexin 6 0.00895518
USO1 USO1 vesicle transport factor 0.00894907
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.00894005

decreased expression

Symbol Name Standardized Value
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.127478
TNS3 tensin 3 -0.111085
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0977303
WWOX WW domain containing oxidoreductase -0.0764005
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -0.0751074
IGF1R insulin-like growth factor 1 receptor -0.0737372
PTGR1 prostaglandin reductase 1 -0.0721636
RAB10 RAB10, member RAS oncogene family -0.0678171
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0656727
ZBTB20 zinc finger and BTB domain containing 20 -0.0645311
WWC1 WW and C2 domain containing 1 -0.0635321
SQSTM1 sequestosome 1 -0.0615363
GPC6 glypican 6 -0.0610588
MED13L mediator complex subunit 13-like -0.0601967
CNTNAP3B contactin associated protein-like 3B -0.0589131
EHBP1 EH domain binding protein 1 -0.0587019
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -0.0572874
LRMDA leucine rich melanocyte differentiation associated -0.0562249
TXNRD1 thioredoxin reductase 1 -0.0560744
THSD7A thrombospondin, type I, domain containing 7A -0.0559955
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0554783
KRT8 keratin 8, type II -0.054871
PARD3 par-3 family cell polarity regulator -0.0547244
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0540901
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.0540063
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -0.0538717
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0513865
SEPTIN9 septin 9 -0.0513423
MYO10 myosin X -0.0511307
CMIP c-Maf inducing protein -0.0510558
BIRC6 baculoviral IAP repeat containing 6 -0.0509184
FLNA filamin A, alpha -0.0505572
MTUS1 microtubule associated tumor suppressor 1 -0.0503203
TTC28 tetratricopeptide repeat domain 28 -0.0499213
CNTN1 contactin 1 -0.0495308
GPATCH8 G patch domain containing 8 -0.0489049
AKAP13 A kinase (PRKA) anchor protein 13 -0.048488
TANK TRAF family member-associated NFKB activator -0.0471596
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0463054
TPM4 tropomyosin 4 -0.0457974
ATXN2 ataxin 2 -0.044833
RBM47 RNA binding motif protein 47 -0.0445297
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0438684
TCF12 transcription factor 12 -0.0438028
ACTG1 actin gamma 1 -0.0432373
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0428336
VMP1 vacuole membrane protein 1 -0.0421172
ACACA acetyl-CoA carboxylase alpha -0.0415275
NRCAM neuronal cell adhesion molecule -0.0407914
CUEDC1 CUE domain containing 1 -0.0401736
BICC1 BicC family RNA binding protein 1 -0.0399878
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0399448
DOCK5 dedicator of cytokinesis 5 -0.0398965
PLD5 phospholipase D family, member 5 -0.0396799
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) -0.0393043
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0387431
BCL2L1 BCL2-like 1 -0.0386803
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0385137
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0384782
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0378889
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0370585
KRT18 keratin 18, type I -0.0366189
EXT1 exostosin glycosyltransferase 1 -0.0365649
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 -0.0360774
MYOF myoferlin -0.0358769
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0354512
BPTF bromodomain PHD finger transcription factor -0.0353686
FLNB filamin B, beta -0.0350241
SPIDR scaffolding protein involved in DNA repair -0.0349107
NRP1 neuropilin 1 -0.0347759
ZNF609 zinc finger protein 609 -0.0347366
GRAMD1A GRAM domain containing 1A -0.034696
SSH2 slingshot protein phosphatase 2 -0.0344314
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 -0.0343435
ENO1 enolase 1, (alpha) -0.0341397
PDE4D phosphodiesterase 4D, cAMP-specific -0.0335215
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0330898
SLC39A11 solute carrier family 39, member 11 -0.0330514
PRKCSH protein kinase C substrate 80K-H -0.0329442
OSBPL10 oxysterol binding protein-like 10 -0.0324778
CUX1 cut-like homeobox 1 -0.0323486
PHGDH phosphoglycerate dehydrogenase -0.0323473
SETD5 SET domain containing 5 -0.0323222
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0323022
CERS6 ceramide synthase 6 -0.0319856
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.0319545
HIP1 huntingtin interacting protein 1 -0.031948
HACD3 3-hydroxyacyl-CoA dehydratase 3 -0.031569
RAP1B RAP1B, member of RAS oncogene family -0.0313576
ARL15 ADP-ribosylation factor-like 15 -0.0311505
MSI2 musashi RNA-binding protein 2 -0.0309803
BMPR1B bone morphogenetic protein receptor, type IB -0.0303576
KPNB1 karyopherin (importin) beta 1 -0.0303009
RORA RAR-related orphan receptor A -0.030169
LITAF lipopolysaccharide-induced TNF factor -0.0295499
KIF13A kinesin family member 13A -0.0294926
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -0.0294799
MAP7 microtubule-associated protein 7 -0.0294742
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0293937
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0293297
BCAS3 breast carcinoma amplified sequence 3 -0.0290001
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0283287
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0283251
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0281488
FRMD3 FERM domain containing 3 -0.028026
METTL16 methyltransferase like 16 -0.0280174
CLIP2 CAP-GLY domain containing linker protein 2 -0.0278252
PTPRF protein tyrosine phosphatase, receptor type, F -0.0277348
CENPF centromere protein F, 350/400kDa -0.0277059
CDC27 cell division cycle 27 -0.0276528
UBA2 ubiquitin-like modifier activating enzyme 2 -0.027647
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 -0.0275342
AOPEP aminopeptidase O (putative) -0.027485
LTBP1 latent transforming growth factor beta binding protein 1 -0.0274533
USP3 ubiquitin specific peptidase 3 -0.0274256
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 -0.0274043
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0272921
MORF4L1 mortality factor 4 like 1 -0.0271847
PER2 period circadian clock 2 -0.0271665
ANKRD17 ankyrin repeat domain 17 -0.0271543
POTEF POTE ankyrin domain family, member F -0.0271353
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0266896
TPR translocated promoter region, nuclear basket protein -0.0266046
AVL9 AVL9 homolog (S. cerevisiase) -0.0264874
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0264333
AVPI1 arginine vasopressin-induced 1 -0.0264017
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 -0.0263106
PLCB4 phospholipase C, beta 4 -0.0263095
MARCHF7 membrane associated ring-CH-type finger 7 -0.0261577
MACROD2 MACRO domain containing 2 -0.0261477
MED13 mediator complex subunit 13 -0.0260479
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0258649
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0258648
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0257766
HOMER2 homer scaffolding protein 2 -0.0256258
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0252559
MLPH melanophilin -0.0252388
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0250798
PKP4 plakophilin 4 -0.0249823
C5 complement component 5 -0.0249146
CCDC138 coiled-coil domain containing 138 -0.0247714
ARHGAP26 Rho GTPase activating protein 26 -0.0247289
MLXIP MLX interacting protein -0.0246146
TBK1 TANK-binding kinase 1 -0.0245898
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0244602
CYRIB CYFIP related Rac1 interactor B -0.0244425
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 -0.0242767
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0241097
CHD9 chromodomain helicase DNA binding protein 9 -0.0240554
CCND1 cyclin D1 -0.0240102
HM13 histocompatibility (minor) 13 -0.0239551
VCL vinculin -0.0239063
ZNF254 zinc finger protein 254 -0.0238939
R3HDM1 R3H domain containing 1 -0.023817
RBPMS RNA binding protein with multiple splicing -0.0237827
PCNX2 pecanex 2 -0.0237633
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0236327
UNK unkempt family zinc finger -0.0235948
COP1 COP1 E3 ubiquitin ligase -0.023586
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 -0.0234429
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -0.0234425
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -0.0232954
WNK1 WNK lysine deficient protein kinase 1 -0.0231441
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) -0.0231043
GCN1 GCN1 activator of EIF2AK4 -0.0230809
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0230776
NOP58 NOP58 ribonucleoprotein -0.0228484
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -0.0228079
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0227045
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0226032
GTF2IRD1 GTF2I repeat domain containing 1 -0.0225157
SRSF4 serine/arginine-rich splicing factor 4 -0.0224808
CCND3 cyclin D3 -0.0224144
SMAD6 SMAD family member 6 -0.0223965
CNKSR3 CNKSR family member 3 -0.0223665
DTNB dystrobrevin, beta -0.022308
EXOC6B exocyst complex component 6B -0.0222919
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0222848
TNRC6A trinucleotide repeat containing 6A -0.0222361
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0222342
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) -0.0222008
FGB fibrinogen beta chain -0.0221576
EXOC6 exocyst complex component 6 -0.0220959
NCOA3 nuclear receptor coactivator 3 -0.0219916
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 -0.0219768
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0218971
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0218932
NF1 neurofibromin 1 -0.021875
PHIP pleckstrin homology domain interacting protein -0.0217032
MRTFA myocardin related transcription factor A -0.0216421
DIAPH2 diaphanous-related formin 2 -0.0215466
CYSTM1 cysteine-rich transmembrane module containing 1 -0.0214582
FOSL1 FOS-like antigen 1 -0.0214289
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0213744
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0212855
AKAP9 A kinase (PRKA) anchor protein 9 -0.0212805
LARP1 La ribonucleoprotein domain family, member 1 -0.0211195
PDZD8 PDZ domain containing 8 -0.0211174
RNF213 ring finger protein 213 -0.0208747
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0208192
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0207846
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma -0.0207738
TENT2 terminal nucleotidyltransferase 2 -0.0207154
EVA1C eva-1 homolog C (C. elegans) -0.0206144
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase -0.0205999
WWP2 WW domain containing E3 ubiquitin protein ligase 2 -0.0205401
CADM1 cell adhesion molecule 1 -0.0204754
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0204546
NEO1 neogenin 1 -0.0204487
PTEN phosphatase and tensin homolog -0.0203401
UBAP2 ubiquitin associated protein 2 -0.0203196
VEZT vezatin, adherens junctions transmembrane protein -0.0203133
CDK17 cyclin-dependent kinase 17 -0.020287
RPN2 ribophorin II -0.0202012
JMJD1C jumonji domain containing 1C -0.0202002
PTPRS protein tyrosine phosphatase, receptor type, S -0.020166
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0200308
NSD1 nuclear receptor binding SET domain protein 1 -0.020018
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa -0.0199938
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0199585
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -0.0199249
RABEP1 rabaptin, RAB GTPase binding effector protein 1 -0.019867
MYDGF myeloid-derived growth factor -0.0197785
FYCO1 FYVE and coiled-coil domain containing 1 -0.0197334
NUMB numb homolog (Drosophila) -0.0197326
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0196964
RNASE12 ribonuclease, RNase A family, 12 (non-active) -0.0196727
XPO1 exportin 1 -0.0196583
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0196583
SMYD3 SET and MYND domain containing 3 -0.0196007
ECPAS Ecm29 proteasome adaptor and scaffold -0.0195538
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -0.0194713
GPR39 G protein-coupled receptor 39 -0.0194369
COX5A cytochrome c oxidase subunit Va -0.0193624
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0193334
NUP153 nucleoporin 153kDa -0.0193226
PKN2 protein kinase N2 -0.019235
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -0.0190693
PCNX1 pecanex 1 -0.01905
DIAPH1 diaphanous-related formin 1 -0.0190086
UBE2K ubiquitin-conjugating enzyme E2K -0.0189976
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0189448
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.01887
SH3D19 SH3 domain containing 19 -0.0188533
LRP5 low density lipoprotein receptor-related protein 5 -0.018752
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0187457
CELF1 CUGBP, Elav-like family member 1 -0.0187433
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0187309
TXN2 thioredoxin 2 -0.018717
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H -0.0187061
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha -0.0187017
DLG1 discs, large homolog 1 (Drosophila) -0.0186983
ERMP1 endoplasmic reticulum metallopeptidase 1 -0.0186468
GCFC2 GC-rich sequence DNA-binding factor 2 -0.0186299
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.018538
GLIS3 GLIS family zinc finger 3 -0.0185378
HDAC8 histone deacetylase 8 -0.0184526
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.018386
LPP LIM domain containing preferred translocation partner in lipoma -0.0183811
EPC2 enhancer of polycomb homolog 2 (Drosophila) -0.0182357
METTL15 methyltransferase like 15 -0.0179874
FAT1 FAT atypical cadherin 1 -0.0179795
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0178667
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0178356
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0177244
NCEH1 neutral cholesterol ester hydrolase 1 -0.0176523
GSE1 Gse1 coiled-coil protein -0.0175159
RBL1 retinoblastoma-like 1 -0.0174384
RIC8B RIC8 guanine nucleotide exchange factor B -0.0174352
PDXK pyridoxal (pyridoxine, vitamin B6) kinase -0.0174192
ZFR zinc finger RNA binding protein -0.0174108
EPB41 erythrocyte membrane protein band 4.1 -0.0174088
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0173564
PHTF2 putative homeodomain transcription factor 2 -0.0173085
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.0172682
PPP1R9A protein phosphatase 1, regulatory subunit 9A -0.0172276
PTPRG protein tyrosine phosphatase, receptor type, G -0.0171918
SKIL SKI-like proto-oncogene -0.0171812
SNX27 sorting nexin family member 27 -0.017162
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -0.0171325
HSPG2 heparan sulfate proteoglycan 2 -0.0171266
ABI1 abl-interactor 1 -0.0171069
GATAD2B GATA zinc finger domain containing 2B -0.0171052
PARN poly(A)-specific ribonuclease -0.017097
ETNK1 ethanolamine kinase 1 -0.0170672
KIFC3 kinesin family member C3 -0.0170484
PBRM1 polybromo 1 -0.0170178
RBM39 RNA binding motif protein 39 -0.0170097
DENND1A DENN/MADD domain containing 1A -0.0170067
NAP1L1 nucleosome assembly protein 1-like 1 -0.0169899
PDE4B phosphodiesterase 4B, cAMP-specific -0.0169184
LMBR1 limb development membrane protein 1 -0.0168958
SBNO1 strawberry notch homolog 1 (Drosophila) -0.0168754
SFXN5 sideroflexin 5 -0.0168702
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0168588
TGOLN2 trans-golgi network protein 2 -0.0168518
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0168473
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0168099
ALG8 ALG8, alpha-1,3-glucosyltransferase -0.0167923
TMCC1 transmembrane and coiled-coil domain family 1 -0.0167768
ZNF518A zinc finger protein 518A -0.0166361
NSD3 nuclear receptor binding SET domain protein 3 -0.0166296
KHDC4 KH domain containing 4, pre-mRNA splicing factor -0.016616
RPTOR regulatory associated protein of MTOR, complex 1 -0.0165926
TGFBI transforming growth factor, beta-induced, 68kDa -0.0165829
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0165158
TOM1L1 target of myb1 (chicken)-like 1 -0.0164347
FOXN3 forkhead box N3 -0.0164067
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0163204
PALLD palladin, cytoskeletal associated protein -0.0162819
TRNAU1AP tRNA selenocysteine 1 associated protein 1 -0.0162389
GPHRA golgi pH regulator A -0.0162286
RBBP8 retinoblastoma binding protein 8 -0.0162002
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0161964
PARD3B par-3 family cell polarity regulator beta -0.0161684
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0161514
API5 apoptosis inhibitor 5 -0.0161102
NT5C2 5'-nucleotidase, cytosolic II -0.0160633
CDK5RAP2 CDK5 regulatory subunit associated protein 2 -0.0160568
ITGAV integrin, alpha V -0.016008
EIF1 eukaryotic translation initiation factor 1 -0.0159445
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 -0.0158761
XBP1 X-box binding protein 1 -0.0158749
CNOT10 CCR4-NOT transcription complex, subunit 10 -0.0158644
RPAP2 RNA polymerase II associated protein 2 -0.015861
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic) -0.0158526
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2 -0.0158378
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0158269
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0157962
PTGES2 prostaglandin E synthase 2 -0.0157582
CUL1 cullin 1 -0.0157378
RBM6 RNA binding motif protein 6 -0.0157281
CNOT4 CCR4-NOT transcription complex, subunit 4 -0.0156811
FAF2 Fas associated factor family member 2 -0.0156615
GALK2 galactokinase 2 -0.0156569
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) -0.0156347
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0156267
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0155873
IL6ST interleukin 6 signal transducer -0.0155764
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0155728
ZNF638 zinc finger protein 638 -0.0155527
PATJ PATJ crumbs cell polarity complex component -0.015547
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0154528
HIPK2 homeodomain interacting protein kinase 2 -0.015384
FAM222B family with sequence similarity 222, member B -0.0153776
TFPI2 tissue factor pathway inhibitor 2 -0.0153722
SOAT1 sterol O-acyltransferase 1 -0.0153234
OPHN1 oligophrenin 1 -0.0152836
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0152557
DNAH14 dynein, axonemal, heavy chain 14 -0.0152161
GPR135 G protein-coupled receptor 135 -0.0151907
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0151635
STRBP spermatid perinuclear RNA binding protein -0.0151201
EDN1 endothelin 1 -0.0150928
SMC4 structural maintenance of chromosomes 4 -0.0150834
MSH2 mutS homolog 2 -0.0150085
MAP3K21 mitogen-activated protein kinase kinase kinase 21 -0.0149868
TBCA tubulin folding cofactor A -0.0149539
RIN2 Ras and Rab interactor 2 -0.0149427
IRF3 interferon regulatory factor 3 -0.0149283
MPRIP myosin phosphatase Rho interacting protein -0.0148961
SHMT1 serine hydroxymethyltransferase 1 (soluble) -0.014891
CORO1C coronin, actin binding protein, 1C -0.0148569
BCAS1 breast carcinoma amplified sequence 1 -0.0148485
ZNRF3 zinc and ring finger 3 -0.0148436
NCOR2 nuclear receptor corepressor 2 -0.0148387
UIMC1 ubiquitin interaction motif containing 1 -0.0148224
EIF4B eukaryotic translation initiation factor 4B -0.0147528
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0147383
PAWR PRKC, apoptosis, WT1, regulator -0.0147361
LDHB lactate dehydrogenase B -0.0147349
BRCA1 breast cancer 1, early onset -0.0147055
CP ceruloplasmin (ferroxidase) -0.014704
OSBPL8 oxysterol binding protein-like 8 -0.0146986
USP34 ubiquitin specific peptidase 34 -0.0146104
SMC5 structural maintenance of chromosomes 5 -0.014458
KIAA0319L KIAA0319-like -0.0144157
DCDC2 doublecortin domain containing 2 -0.0144003
TRIO trio Rho guanine nucleotide exchange factor -0.0143403
PCED1B PC-esterase domain containing 1B -0.0143306
WDPCP WD repeat containing planar cell polarity effector -0.0142914
TCP11L1 t-complex 11, testis-specific-like 1 -0.0142857
TTC7A tetratricopeptide repeat domain 7A -0.0142856
ZNF652 zinc finger protein 652 -0.0142584
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 -0.0142487
FOXP1 forkhead box P1 -0.0142188
PPP1R13B protein phosphatase 1, regulatory subunit 13B -0.0141882
UBASH3B ubiquitin associated and SH3 domain containing B -0.0141358
KLHDC4 kelch domain containing 4 -0.0141235
NUP107 nucleoporin 107kDa -0.0140877
TSEN2 TSEN2 tRNA splicing endonuclease subunit -0.0140823
CPT1A carnitine palmitoyltransferase 1A (liver) -0.0140753
FOXA2 forkhead box A2 -0.0140493
HOOK3 hook microtubule-tethering protein 3 -0.0140459
ATXN3 ataxin 3 -0.0140412
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0140183
STK32B serine/threonine kinase 32B -0.0140149
GLG1 golgi glycoprotein 1 -0.0140023
SP3 Sp3 transcription factor -0.0139972
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.013995
KDM3B lysine (K)-specific demethylase 3B -0.0139835
FUS FUS RNA binding protein -0.0139713
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0139436
MAP4 microtubule-associated protein 4 -0.0139411
ZNF618 zinc finger protein 618 -0.0139207
TM4SF4 transmembrane 4 L six family member 4 -0.0139185
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0139158
ANLN anillin, actin binding protein -0.0139136
KATNBL1 katanin p80 subunit B-like 1 -0.0139035
ACTN1 actinin, alpha 1 -0.013903
SLC30A5 solute carrier family 30 (zinc transporter), member 5 -0.0138778
RPL18 ribosomal protein L18 -0.0138747
FAM114A1 family with sequence similarity 114, member A1 -0.0138271
MTDH metadherin -0.013814
ZMAT4 zinc finger, matrin-type 4 -0.0137839
PCSK5 proprotein convertase subtilisin/kexin type 5 -0.0137348
CCDC12 coiled-coil domain containing 12 -0.0137115
R3HDM2 R3H domain containing 2 -0.013697
OSGIN2 oxidative stress induced growth inhibitor family member 2 -0.0136951
TBL1X transducin (beta)-like 1X-linked -0.0136635
ZC3H14 zinc finger CCCH-type containing 14 -0.0136196
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0136176
DCAF10 DDB1 and CUL4 associated factor 10 -0.0136171
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -0.0136113
SLX4IP SLX4 interacting protein -0.013602
GSR glutathione reductase -0.0135964
SINHCAF SIN3-HDAC complex associated factor -0.0135544
ELMO1 engulfment and cell motility 1 -0.0135514
NAP1L4 nucleosome assembly protein 1-like 4 -0.0135357
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit -0.0135107
FUCA2 fucosidase, alpha-L- 2, plasma -0.0134838
KRT7 keratin 7, type II -0.0134101
ITFG2 integrin alpha FG-GAP repeat containing 2 -0.013397
KIF14 kinesin family member 14 -0.0133553
FAM168B family with sequence similarity 168, member B -0.0133373
GPBP1 GC-rich promoter binding protein 1 -0.0133351
MEGF9 multiple EGF-like-domains 9 -0.0133323
KNTC1 kinetochore associated 1 -0.0133263
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 -0.013322
UGDH UDP-glucose 6-dehydrogenase -0.0133076
WDFY1 WD repeat and FYVE domain containing 1 -0.0132853
LAMB1 laminin, beta 1 -0.0132811
KTN1 kinectin 1 (kinesin receptor) -0.0132694
ELL2 elongation factor, RNA polymerase II, 2 -0.0132627
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) -0.0132198
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0131644
WWTR1 WW domain containing transcription regulator 1 -0.0131577
CPPED1 calcineurin-like phosphoesterase domain containing 1 -0.0131183
SNX1 sorting nexin 1 -0.0130838
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0130795
SEC31A SEC31 homolog A (S. cerevisiae) -0.0130661
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 -0.0130591
BLTP3B bridge-like lipid transfer protein family member 3B -0.0130393
SIL1 SIL1 nucleotide exchange factor -0.0130293
PHC3 polyhomeotic homolog 3 (Drosophila) -0.0130284
SLC39A9 solute carrier family 39, member 9 -0.0130228
DDB2 damage-specific DNA binding protein 2, 48kDa -0.0129418
ZFYVE9 zinc finger, FYVE domain containing 9 -0.0129174
AFG2A AFG2 AAA ATPase homolog A -0.0129023
DENND4A DENN/MADD domain containing 4A -0.0128836
FBXO11 F-box protein 11 -0.0128733
TNRC18 trinucleotide repeat containing 18 -0.0128728
RPS27A ribosomal protein S27a -0.0128564
PROCR protein C receptor, endothelial -0.0128473
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 -0.0128454
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0128367
COL4A5 collagen, type IV, alpha 5 -0.012822
DICER1 dicer 1, ribonuclease type III -0.0128196
QSER1 glutamine and serine rich 1 -0.0128025
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits -0.0127876
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit -0.0127875
GTSE1 G-2 and S-phase expressed 1 -0.0127757
HNRNPM heterogeneous nuclear ribonucleoprotein M -0.0127726
SPATS2 spermatogenesis associated, serine-rich 2 -0.0127721
HNRNPL heterogeneous nuclear ribonucleoprotein L -0.0127586
FAM13B family with sequence similarity 13, member B -0.0127473
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 -0.0127432
RBM4 RNA binding motif protein 4 -0.0127325
SLC45A4 solute carrier family 45, member 4 -0.0127279
KDM4C lysine (K)-specific demethylase 4C -0.0127113
SNX8 sorting nexin 8 -0.0127033
CMTM8 CKLF-like MARVEL transmembrane domain containing 8 -0.0126976
MPG N-methylpurine-DNA glycosylase -0.0126727
PALB2 partner and localizer of BRCA2 -0.0126441
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0126227
SENP6 SUMO1/sentrin specific peptidase 6 -0.0126217
LRP12 low density lipoprotein receptor-related protein 12 -0.0126174
FOXK2 forkhead box K2 -0.0126114
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -0.0126108
ETFA electron-transfer-flavoprotein, alpha polypeptide -0.0126051
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 -0.0125397
PHYKPL 5-phosphohydroxy-L-lysine phospho-lyase -0.0125342
RNF43 ring finger protein 43 -0.0125303
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.012515
PRSS23 protease, serine, 23 -0.0125032
DHDDS dehydrodolichyl diphosphate synthase -0.0124639
EP400 E1A binding protein p400 -0.0124599
AHNAK AHNAK nucleoprotein -0.0124535
EMP2 epithelial membrane protein 2 -0.0124333
EFTUD2 elongation factor Tu GTP binding domain containing 2 -0.0124194