A549_Alendronate sodium trihydrate_100nM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description Alendronate sodium trihydrate 100nM perturbation in A549 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the A549_Alendronate sodium trihydrate_100nM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.208314
FTL ferritin, light polypeptide 0.177753
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.113176
KRT81 keratin 81, type II 0.107202
ASPH aspartate beta-hydroxylase 0.106982
GPX2 glutathione peroxidase 2 0.101564
PKM pyruvate kinase, muscle 0.100586
CA12 carbonic anhydrase XII 0.0916855
ENO1 enolase 1, (alpha) 0.0870214
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.0803995
KRT18 keratin 18, type I 0.0767908
CPLX2 complexin 2 0.075532
RPLP1 ribosomal protein, large, P1 0.0690923
MAP1B microtubule-associated protein 1B 0.0642786
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0589007
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.0588475
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0567624
KRT8 keratin 8, type II 0.0562775
TPI1 triosephosphate isomerase 1 0.0536037
MAP7 microtubule-associated protein 7 0.0518189
UGDH UDP-glucose 6-dehydrogenase 0.0506331
ANXA1 annexin A1 0.0500635
AGR2 anterior gradient 2 0.0488847
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0487793
TUBA1B tubulin, alpha 1b 0.0474549
KYNU kynureninase 0.045599
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.044986
RPL19 ribosomal protein L19 0.0430458
RPS2 ribosomal protein S2 0.0401996
NPAS2 neuronal PAS domain protein 2 0.0400981
EREG epiregulin 0.0390037
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0389681
TUBB tubulin, beta class I 0.0386054
VCP valosin containing protein 0.0378339
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0374222
RPL13A ribosomal protein L13a 0.0369859
NRDC nardilysin convertase 0.0366103
AKAP12 A kinase (PRKA) anchor protein 12 0.036584
NEBL nebulette 0.035765
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.035505
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0354439
RBM15 RNA binding motif protein 15 0.0354117
MYO1E myosin IE 0.0349582
STK24 serine/threonine kinase 24 0.0337326
FTH1 ferritin, heavy polypeptide 1 0.0334743
RPS29 ribosomal protein S29 0.0333171
RPLP0 ribosomal protein, large, P0 0.032891
DUSP16 dual specificity phosphatase 16 0.0322915
TMSB10 thymosin beta 10 0.0311099
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0309017
RAD51B RAD51 paralog B 0.0307214
NF1 neurofibromin 1 0.0304924
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0304913
MAML3 mastermind-like 3 (Drosophila) 0.0302821
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0301107
LDHA lactate dehydrogenase A 0.029533
RRBP1 ribosome binding protein 1 0.0295213
ACTN4 actinin, alpha 4 0.0295072
S100A6 S100 calcium binding protein A6 0.0295009
AKR1C2 aldo-keto reductase family 1, member C2 0.0294267
YEATS2 YEATS domain containing 2 0.0293471
ATG10 autophagy related 10 0.0292083
HRNR hornerin 0.0282699
CRK v-crk avian sarcoma virus CT10 oncogene homolog 0.0277645
RPS23 ribosomal protein S23 0.0277283
TPM3 tropomyosin 3 0.0276645
PRKCA protein kinase C, alpha 0.0275481
USF2 upstream transcription factor 2, c-fos interacting 0.0275033
LIN9 lin-9 DREAM MuvB core complex component 0.0274037
GATAD2B GATA zinc finger domain containing 2B 0.0273907
PFN1 profilin 1 0.0270714
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0269876
RPL37A ribosomal protein L37a 0.0269708
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0269422
METTL15 methyltransferase like 15 0.0267517
EMP3 epithelial membrane protein 3 0.0267139
TMCC1 transmembrane and coiled-coil domain family 1 0.0266194
HSPB1 heat shock 27kDa protein 1 0.0265645
RSRC1 arginine/serine-rich coiled-coil 1 0.0264867
FBL fibrillarin 0.0263398
CAPNS1 calpain, small subunit 1 0.0263277
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 0.0258069
PBX1 pre-B-cell leukemia homeobox 1 0.025772
REXO2 RNA exonuclease 2 0.0256224
TRAPPC9 trafficking protein particle complex 9 0.025603
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 0.0255892
HDLBP high density lipoprotein binding protein 0.0255023
MED13L mediator complex subunit 13-like 0.0254842
GRAMD1B GRAM domain containing 1B 0.0254778
RHOBTB1 Rho-related BTB domain containing 1 0.0254761
ARHGAP26 Rho GTPase activating protein 26 0.0254095
GARRE1 granule associated Rac and RHOG effector 1 0.0252923
ADAR adenosine deaminase, RNA-specific 0.0252828
BICC1 BicC family RNA binding protein 1 0.025073
IRF3 interferon regulatory factor 3 0.0250207
ACLY ATP citrate lyase 0.0249268
BLTP2 bridge-like lipid transfer protein family member 2 0.0247985
PHAX phosphorylated adaptor for RNA export 0.0247485
GSTP1 glutathione S-transferase pi 1 0.0246944
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0246857
MYO9B myosin IXB 0.0246556
LOC112694756 uncharaterized LOC112694756 0.0244616
EEF1B2 eukaryotic translation elongation factor 1 beta 2 0.0242607
WNT7B wingless-type MMTV integration site family, member 7B 0.0242227
FDPS farnesyl diphosphate synthase 0.0241568
KDM2A lysine (K)-specific demethylase 2A 0.024127
ITFG1 integrin alpha FG-GAP repeat containing 1 0.0241003
PRKD1 protein kinase D1 0.0240833
DIAPH1 diaphanous-related formin 1 0.024057
DNM2 dynamin 2 0.0240535
SMIM44 small integral membrane protein 44 0.0238812
MGST1 microsomal glutathione S-transferase 1 0.0238615
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0237684
EPS8 epidermal growth factor receptor pathway substrate 8 0.0236098
ABLIM1 actin binding LIM protein 1 0.0234298
MRTFA myocardin related transcription factor A 0.0234206
DST dystonin 0.0233756
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.023234
SETX senataxin 0.0231462
RPL3 ribosomal protein L3 0.0231003
CCT3 chaperonin containing TCP1, subunit 3 (gamma) 0.0230831
TANGO6 transport and golgi organization 6 homolog (Drosophila) 0.0230552
PLEKHA7 pleckstrin homology domain containing, family A member 7 0.0229581
NSD1 nuclear receptor binding SET domain protein 1 0.0229517
SET SET nuclear proto-oncogene 0.0229074
GRB2 growth factor receptor-bound protein 2 0.0228892
TOB1 transducer of ERBB2, 1 0.0228848
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 0.0227796
SDK1 sidekick cell adhesion molecule 1 0.0227356
COX7C cytochrome c oxidase subunit VIIc 0.0226826
SH3KBP1 SH3-domain kinase binding protein 1 0.0226742
MUSK muscle, skeletal, receptor tyrosine kinase 0.0225444
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 0.0222055
PHB2 prohibitin 2 0.0221823
TSPAN14 tetraspanin 14 0.0221491
DCAF7 DDB1 and CUL4 associated factor 7 0.022089
NCKAP1 NCK-associated protein 1 0.0220299
GNAS GNAS complex locus 0.0219985
AGO2 argonaute RISC catalytic component 2 0.0219253
RPL15 ribosomal protein L15 0.0218623
LDAH lipid droplet associated hydrolase 0.021858
CALR calreticulin 0.0218058
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 0.0217857
TLN1 talin 1 0.0217005
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0216138
NUDT5 nudix (nucleoside diphosphate linked moiety X)-type motif 5 0.0213905
DDI2 DNA-damage inducible 1 homolog 2 (S. cerevisiae) 0.0213265
TRAP1 TNF receptor-associated protein 1 0.0213003
KIAA0232 KIAA0232 0.0212899
STRBP spermatid perinuclear RNA binding protein 0.0212771
EPN2 epsin 2 0.0212606
ADGRE5 adhesion G protein-coupled receptor E5 0.0212394
BRI3BP BRI3 binding protein 0.0212208
ZNF592 zinc finger protein 592 0.0212055
MYH9 myosin, heavy chain 9, non-muscle 0.021188
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 0.0211245
ATAD5 ATPase family, AAA domain containing 5 0.0211065
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0210558
HABP4 hyaluronan binding protein 4 0.0209502
CAB39 calcium binding protein 39 0.0209039
RANBP17 RAN binding protein 17 0.0207413
MAP4 microtubule-associated protein 4 0.020439
NTN4 netrin 4 0.0204361
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 0.020332
BARD1 BRCA1 associated RING domain 1 0.0203268
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0202607
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 0.0202044
RPL37 ribosomal protein L37 0.0200874
RHOA ras homolog family member A 0.0200677
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0200423
CNKSR3 CNKSR family member 3 0.0200407
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 0.0199456
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0199235
PTK2 protein tyrosine kinase 2 0.0198912
VTA1 vesicle (multivesicular body) trafficking 1 0.0198863
PHF14 PHD finger protein 14 0.019878
BRCA1 breast cancer 1, early onset 0.0197403
STRN3 striatin, calmodulin binding protein 3 0.0196998
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 0.019695
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0196708
OSMR oncostatin M receptor 0.0196337
TATDN3 TatD DNase domain containing 3 0.0196074
AQR aquarius intron-binding spliceosomal factor 0.0195752
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0194778
HMGB1 high mobility group box 1 0.0194657
RPL9 ribosomal protein L9 0.0193926
CLIC1 chloride intracellular channel 1 0.0193594
FASN fatty acid synthase 0.0192547
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 0.0192499
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 0.0192413
ZFP64 ZFP64 zinc finger protein 0.0192021
CLIP1 CAP-GLY domain containing linker protein 1 0.0191935
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 0.0191688
ZFP36L1 ZFP36 ring finger protein-like 1 0.0191663
TAOK1 TAO kinase 1 0.0191404
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0191391
PDIA6 protein disulfide isomerase family A, member 6 0.0191319
RPS3 ribosomal protein S3 0.0189867
CYBA cytochrome b-245, alpha polypeptide 0.0189568
INTS7 integrator complex subunit 7 0.0189004
HPCAL1 hippocalcin-like 1 0.0188951
PLPP2 phospholipid phosphatase 2 0.0188825
NHSL1 NHS-like 1 0.0188636
CYRIB CYFIP related Rac1 interactor B 0.0188497
CD81 CD81 molecule 0.0188418
CCND1 cyclin D1 0.0187858
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.0187777
PTDSS1 phosphatidylserine synthase 1 0.0187608
PRDX5 peroxiredoxin 5 0.018707
LRRC58 leucine rich repeat containing 58 0.0186214
WWTR1 WW domain containing transcription regulator 1 0.018595
CWF19L2 CWF19-like 2, cell cycle control (S. pombe) 0.0185861
NONO non-POU domain containing, octamer-binding 0.018568
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.0185332
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.0185082
RPL39 ribosomal protein L39 0.0184296
NOL10 nucleolar protein 10 0.0184033
RPSA ribosomal protein SA 0.0183743
RPL18 ribosomal protein L18 0.0183505
PTMS parathymosin 0.0182166
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.018196
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.0181925
MLPH melanophilin 0.0181777
WDHD1 WD repeat and HMG-box DNA binding protein 1 0.0181079
MPG N-methylpurine-DNA glycosylase 0.0180204
IARS1 isoleucyl-tRNA synthetase 1 0.0179749
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.0179689
ZNF367 zinc finger protein 367 0.0179413
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0179394
DCAF5 DDB1 and CUL4 associated factor 5 0.0178735
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0178669
CYB5B cytochrome b5 type B (outer mitochondrial membrane) 0.0178658
XPO1 exportin 1 0.0178327
KIF2A kinesin heavy chain member 2A 0.0178232
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 0.0178184
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa 0.0178082
PRELID2 PRELI domain containing 2 0.0177414
PDE7B phosphodiesterase 7B 0.0177233
PHACTR4 phosphatase and actin regulator 4 0.0175767
BMP6 bone morphogenetic protein 6 0.0175535
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.017523
ARHGAP11B Rho GTPase activating protein 11B 0.0175081
CENPF centromere protein F, 350/400kDa 0.0174744
PRR11 proline rich 11 0.0174466
LIPH lipase, member H 0.017432
MKI67 marker of proliferation Ki-67 0.0173828
DLG1 discs, large homolog 1 (Drosophila) 0.0173821
PA2G4 proliferation-associated 2G4, 38kDa 0.0173502
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0172695
ANKRD26 ankyrin repeat domain 26 0.0172143
CIAPIN1 cytokine induced apoptosis inhibitor 1 0.0171922
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0171676
TLK1 tousled-like kinase 1 0.0171283
RPS8 ribosomal protein S8 0.0171267
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 0.0170772
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0170721
HCFC1 host cell factor C1 0.0170356
S100A11 S100 calcium binding protein A11 0.0170129
FLNA filamin A, alpha 0.0170103
ATP5MJ ATP synthase membrane subunit j 0.0169924
PTPRF protein tyrosine phosphatase, receptor type, F 0.0169749
ZSCAN5A zinc finger and SCAN domain containing 5A 0.0169596
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0169238
MBNL1 muscleblind-like splicing regulator 1 0.0169081
TMEM181 transmembrane protein 181 0.0169066
RHOC ras homolog family member C 0.0168333
SRPK1 SRSF protein kinase 1 0.0167817
TTC27 tetratricopeptide repeat domain 27 0.0167712
ELOVL6 ELOVL fatty acid elongase 6 0.0167448
TXNL1 thioredoxin-like 1 0.0167401
PRKX protein kinase, X-linked 0.0167175
RPL38 ribosomal protein L38 0.0166975
USP37 ubiquitin specific peptidase 37 0.016695
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.0166948
DARS1 aspartyl-tRNA synthetase 1 0.016639
PTPN2 protein tyrosine phosphatase, non-receptor type 2 0.0166367
SCGB2B2 secretoglobin, family 2B, member 2 0.0165656
PYGB phosphorylase, glycogen; brain 0.0165626
BSG basigin (Ok blood group) 0.0165433
MCM4 minichromosome maintenance complex component 4 0.0165415
CEMIP2 cell migration inducing hyaluronidase 2 0.0165343
COX15 cytochrome c oxidase assembly homolog 15 (yeast) 0.0165015
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0164251
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0163125
RBBP6 retinoblastoma binding protein 6 0.0163106
SEC24B SEC24 family member B 0.0162877
RPS20 ribosomal protein S20 0.0162861
CHD1 chromodomain helicase DNA binding protein 1 0.0162785
C12ORF75 chromosome 12 open reading frame 75 0.0162525
ILF3 interleukin enhancer binding factor 3, 90kDa 0.0162325
WDR76 WD repeat domain 76 0.0162098
TLK2 tousled-like kinase 2 0.0161716
SLX4IP SLX4 interacting protein 0.0160843
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 0.0160818
PRR14L proline rich 14-like 0.0160799
NCOR2 nuclear receptor corepressor 2 0.0160527
SNX13 sorting nexin 13 0.0160208
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0160033
ANKH ANKH inorganic pyrophosphate transport regulator 0.0159926
LASP1 LIM and SH3 protein 1 0.0159758
UBE2G2 ubiquitin-conjugating enzyme E2G 2 0.0159352
CTSA cathepsin A 0.015931
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.0159082
TTLL10 tubulin tyrosine ligase-like family member 10 0.015906
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 0.015832
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0158168
BBS4 Bardet-Biedl syndrome 4 0.0157963
MAF1 MAF1 homolog (S. cerevisiae) 0.01578
TMEM141 transmembrane protein 141 0.0157783
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.0156816
LRP5 low density lipoprotein receptor-related protein 5 0.0156466
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.01562
CFDP1 craniofacial development protein 1 0.0155965
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0155946
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0155803
CARS1 cysteinyl-tRNA synthetase 1 0.0155796
BORCS5 BLOC-1 related complex subunit 5 0.0155659
PKN1 protein kinase N1 0.015555
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.0155482
AURKB aurora kinase B 0.015546
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 0.0155357
RPL36 ribosomal protein L36 0.015513
SLCO3A1 solute carrier organic anion transporter family, member 3A1 0.0155074
XRRA1 X-ray radiation resistance associated 1 0.0155051
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) 0.0154891
EFTUD2 elongation factor Tu GTP binding domain containing 2 0.0154739
LRIF1 ligand dependent nuclear receptor interacting factor 1 0.0154636
TNPO3 transportin 3 0.0154619
MYO5C myosin VC 0.0154506
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0154464
MYO1B myosin IB 0.0154085
SCN8A sodium channel, voltage gated, type VIII alpha subunit 0.0153804
EIF4B eukaryotic translation initiation factor 4B 0.0153742
PCSK7 proprotein convertase subtilisin/kexin type 7 0.0153537
AP2A1 adaptor-related protein complex 2, alpha 1 subunit 0.0153473
USP24 ubiquitin specific peptidase 24 0.015301
BCL3 B-cell CLL/lymphoma 3 0.0152804
MSH6 mutS homolog 6 0.0152803
XPO7 exportin 7 0.0152638
TGFB1 transforming growth factor, beta 1 0.0152627
EDF1 endothelial differentiation-related factor 1 0.0152445
SLC12A9 solute carrier family 12, member 9 0.0152106
YBX1 Y box binding protein 1 0.0151854
CD99L2 CD99 molecule-like 2 0.0151233
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0151144
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 0.0150855
ULK4 unc-51 like kinase 4 0.015074
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0150407
RPS7 ribosomal protein S7 0.0150381
PUS7 pseudouridylate synthase 7 (putative) 0.0150228
ZNF169 zinc finger protein 169 0.0149877
SNX24 sorting nexin 24 0.0149364
RPS17 ribosomal protein S17 0.0149223
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 0.0148726
OGA O-GlcNAcase 0.0148619
ZNFX1 zinc finger, NFX1-type containing 1 0.0148558
ZNF3 zinc finger protein 3 0.014832
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) 0.014802
MTBP MDM2 binding protein 0.0147805
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 0.0147114
ATXN7L1 ataxin 7-like 1 0.0147106
COLGALT1 collagen beta(1-O)galactosyltransferase 1 0.0146716
ACOT9 acyl-CoA thioesterase 9 0.0146601
RNASEH1 ribonuclease H1 0.0146413
VIRMA vir like m6A methyltransferase associated 0.0146157
NOP56 NOP56 ribonucleoprotein 0.0145913
FUBP3 far upstream element (FUSE) binding protein 3 0.0145891
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) 0.014566
RDH10 retinol dehydrogenase 10 (all-trans) 0.0145572
TMED2 transmembrane emp24 domain trafficking protein 2 0.0145401
SERGEF secretion regulating guanine nucleotide exchange factor 0.0145347
GPR135 G protein-coupled receptor 135 0.0144987
CSRP1 cysteine and glycine-rich protein 1 0.0144969
EIF3B eukaryotic translation initiation factor 3, subunit B 0.0144568
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 0.0144251
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0143974
ALG8 ALG8, alpha-1,3-glucosyltransferase 0.0143924
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0143691
CEP112 centrosomal protein 112kDa 0.014347
WDR12 WD repeat domain 12 0.0143415
ANKLE2 ankyrin repeat and LEM domain containing 2 0.0143158
CTDNEP1 CTD nuclear envelope phosphatase 1 0.0143115
SLK STE20-like kinase 0.0142786
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae) 0.0142294
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 0.014152
KIF16B kinesin family member 16B 0.0141082
GRWD1 glutamate-rich WD repeat containing 1 0.0141065
VASP vasodilator-stimulated phosphoprotein 0.0140963
ANKRD28 ankyrin repeat domain 28 0.0140963
RPS27 ribosomal protein S27 0.0140953
RSL1D1 ribosomal L1 domain containing 1 0.0140894
NT5DC2 5'-nucleotidase domain containing 2 0.0140837
CDC42SE2 CDC42 small effector 2 0.0140775
BRMS1L breast cancer metastasis-suppressor 1-like 0.0140669
EFCAB13 EF-hand calcium binding domain 13 0.0140561
NPDC1 neural proliferation, differentiation and control, 1 0.0140389
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0140353
RPS15A ribosomal protein S15a 0.0139945
VARS1 valyl-tRNA synthetase 1 0.013989
NUP107 nucleoporin 107kDa 0.0139714
SRP72 signal recognition particle 72kDa 0.013941
EYA3 EYA transcriptional coactivator and phosphatase 3 0.0138967
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa 0.013868
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 0.0138597
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae) 0.0138386
CS citrate synthase 0.0138152
MTFMT mitochondrial methionyl-tRNA formyltransferase 0.013766
NAP1L4 nucleosome assembly protein 1-like 4 0.0137367
TSC22D2 TSC22 domain family, member 2 0.0137326
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 0.0137252
TUFM Tu translation elongation factor, mitochondrial 0.0137208
NCBP3 nuclear cap binding subunit 3 0.0136979
PDE10A phosphodiesterase 10A 0.0136855
ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) 0.0136707
NEK7 NIMA-related kinase 7 0.0136546
MAN2B1 mannosidase, alpha, class 2B, member 1 0.0136458
BAX BCL2-associated X protein 0.0136398
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0136346
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.0136328
WASF2 WAS protein family, member 2 0.0136205
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.0135622
DCLK2 doublecortin-like kinase 2 0.0135554
SIN3A SIN3 transcription regulator family member A 0.0134999
SNX8 sorting nexin 8 0.01349
CD151 CD151 molecule (Raph blood group) 0.0134822
DTWD2 DTW domain containing 2 0.0134545
NFE2L1 nuclear factor, erythroid 2-like 1 0.0134365
BTBD10 BTB (POZ) domain containing 10 0.0134327
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 0.0134296
S100A10 S100 calcium binding protein A10 0.0134232
INTS10 integrator complex subunit 10 0.0134027
SSH1 slingshot protein phosphatase 1 0.0133976
RECQL RecQ helicase-like 0.013389
RPL32 ribosomal protein L32 0.0133861
GJD3 gap junction protein, delta 3, 31.9kDa 0.0133666
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) 0.013348
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0133266
TMEM97 transmembrane protein 97 0.0133003
STK4 serine/threonine kinase 4 0.0132769
RNF169 ring finger protein 169 0.013271
MAP2K3 mitogen-activated protein kinase kinase 3 0.0132521
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0131807
BCL2L2-PABPN1 BCL2L2-PABPN1 readthrough 0.013179
RPS6 ribosomal protein S6 0.013166
DCTN1 dynactin 1 0.0131366
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0131276
VSIG10 V-set and immunoglobulin domain containing 10 0.0131019
SH3PXD2A SH3 and PX domains 2A 0.0130898
ADPGK ADP-dependent glucokinase 0.013079
CCDC125 coiled-coil domain containing 125 0.0130772
UQCC2 ubiquinol-cytochrome c reductase complex assembly factor 2 0.0130689
RPL26 ribosomal protein L26 0.0130536
TMX4 thioredoxin-related transmembrane protein 4 0.0130294
TSKU tsukushi, small leucine rich proteoglycan 0.0130132
MB21D2 Mab-21 domain containing 2 0.013004
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.0129859
MMS22L MMS22-like, DNA repair protein 0.0129827
ZNF518A zinc finger protein 518A 0.0129824
FANCM Fanconi anemia, complementation group M 0.0129784
DOCK1 dedicator of cytokinesis 1 0.0129678
UBTF upstream binding transcription factor, RNA polymerase I 0.0129594
HJURP Holliday junction recognition protein 0.012949
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.0129106
DTYMK deoxythymidylate kinase (thymidylate kinase) 0.0128996
LMNB1 lamin B1 0.0128983
WDR59 WD repeat domain 59 0.0128968
ETV6 ets variant 6 0.0128921
ASXL2 additional sex combs like transcriptional regulator 2 0.0128775
UFC1 ubiquitin-fold modifier conjugating enzyme 1 0.0128755
DSPP dentin sialophosphoprotein 0.0128729
NUP214 nucleoporin 214kDa 0.0127753
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 0.0127654
ELMOD3 ELMO/CED-12 domain containing 3 0.0127632
ADNP activity-dependent neuroprotector homeobox 0.01276
TTC7B tetratricopeptide repeat domain 7B 0.0127479
FAT1 FAT atypical cadherin 1 0.0127379
JADE3 jade family PHD finger 3 0.0127283
ARID1A AT rich interactive domain 1A (SWI-like) 0.0127046
EEA1 early endosome antigen 1 0.012704
HOMER1 homer scaffolding protein 1 0.0127008
FLYWCH1 FLYWCH-type zinc finger 1 0.0126919
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0126781
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit 0.0126675
TM4SF1 transmembrane 4 L six family member 1 0.0126606
DEPDC1B DEP domain containing 1B 0.0126516
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 0.0126336
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0126211
SLC39A4 solute carrier family 39 (zinc transporter), member 4 0.0126137
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35 0.0126135
OSBPL9 oxysterol binding protein-like 9 0.012606
HMGA1 high mobility group AT-hook 1 0.0125991
TBC1D23 TBC1 domain family, member 23 0.0125834
ZFAND5 zinc finger, AN1-type domain 5 0.0125302
SF3A3 splicing factor 3a, subunit 3, 60kDa 0.012502
C11ORF58 chromosome 11 open reading frame 58 0.0124993
TRIM56 tripartite motif containing 56 0.0124793
RFC3 replication factor C (activator 1) 3, 38kDa 0.0124773
ZNF567 zinc finger protein 567 0.0124557
NR2C1 nuclear receptor subfamily 2, group C, member 1 0.0124455
RPS21 ribosomal protein S21 0.0124405

decreased expression

Symbol Name Standardized Value
CNTN1 contactin 1 -0.10981
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.102938
RAB10 RAB10, member RAS oncogene family -0.102553
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0865421
FN1 fibronectin 1 -0.0842283
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0814701
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0794702
THSD7A thrombospondin, type I, domain containing 7A -0.0758223
MTUS1 microtubule associated tumor suppressor 1 -0.0697143
SQSTM1 sequestosome 1 -0.0682091
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0678419
CHD9 chromodomain helicase DNA binding protein 9 -0.0632505
IGF1R insulin-like growth factor 1 receptor -0.0631132
PCDHB16 protocadherin beta 16 -0.0621883
SYT1 synaptotagmin I -0.0616753
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0612757
ANXA4 annexin A4 -0.0580945
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -0.0568189
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0529698
ARHGAP5 Rho GTPase activating protein 5 -0.0529024
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -0.0525458
CNTNAP3B contactin associated protein-like 3B -0.0515606
ANXA2 annexin A2 -0.0509911
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0498997
AOPEP aminopeptidase O (putative) -0.0493615
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0491958
PDE4D phosphodiesterase 4D, cAMP-specific -0.0490111
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0489191
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0486765
GRAMD1A GRAM domain containing 1A -0.0485889
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0470448
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0465937
DAPK1 death-associated protein kinase 1 -0.0460919
CD44 CD44 molecule (Indian blood group) -0.045441
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.0454342
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.0453361
THSD4 thrombospondin, type I, domain containing 4 -0.0452918
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0448277
RBM39 RNA binding motif protein 39 -0.043535
EXT1 exostosin glycosyltransferase 1 -0.0430618
APP amyloid beta (A4) precursor protein -0.042192
PTPRK protein tyrosine phosphatase, receptor type, K -0.0420991
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -0.041856
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0412928
EHBP1 EH domain binding protein 1 -0.0412216
TACC1 transforming, acidic coiled-coil containing protein 1 -0.0408674
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 -0.0407413
MICU1 mitochondrial calcium uptake 1 -0.0405102
GPC6 glypican 6 -0.0395201
ALCAM activated leukocyte cell adhesion molecule -0.039009
USP32 ubiquitin specific peptidase 32 -0.0388559
CP ceruloplasmin (ferroxidase) -0.038601
ZFAND3 zinc finger, AN1-type domain 3 -0.0382581
TNS3 tensin 3 -0.038209
ZBTB20 zinc finger and BTB domain containing 20 -0.0379333
GCLC glutamate-cysteine ligase, catalytic subunit -0.0376782
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0373574
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0372429
PPP1R9A protein phosphatase 1, regulatory subunit 9A -0.0371811
MYADM myeloid-associated differentiation marker -0.0369684
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0368139
MSI2 musashi RNA-binding protein 2 -0.0362603
NRG1 neuregulin 1 -0.0361348
UBAP2 ubiquitin associated protein 2 -0.0359834
MYOF myoferlin -0.0359059
LRP6 low density lipoprotein receptor-related protein 6 -0.0355647
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0351578
BMPR1B bone morphogenetic protein receptor, type IB -0.0350957
SMYD3 SET and MYND domain containing 3 -0.0350701
BPTF bromodomain PHD finger transcription factor -0.0350582
LRMDA leucine rich melanocyte differentiation associated -0.0349153
HIPK2 homeodomain interacting protein kinase 2 -0.0347771
THADA thyroid adenoma associated -0.0344988
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) -0.0344597
RBM47 RNA binding motif protein 47 -0.0342184
MLEC malectin -0.0339034
ZMYM2 zinc finger, MYM-type 2 -0.0338826
SPATS2 spermatogenesis associated, serine-rich 2 -0.0338346
EPB41L4A erythrocyte membrane protein band 4.1 like 4A -0.0335999
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.033483
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0334647
FRMD5 FERM domain containing 5 -0.0326789
SPNS1 spinster homolog 1 (Drosophila) -0.0322096
FBXO17 F-box protein 17 -0.0319322
CCND3 cyclin D3 -0.031905
PIAS1 protein inhibitor of activated STAT, 1 -0.0317309
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.0315995
MCU mitochondrial calcium uniporter -0.0310131
CDK13 cyclin-dependent kinase 13 -0.0308705
THOC2 THO complex 2 -0.0307387
TMEM117 transmembrane protein 117 -0.0306265
AKAP13 A kinase (PRKA) anchor protein 13 -0.0302762
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0298651
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0298364
JMJD1C jumonji domain containing 1C -0.0297361
FRMD3 FERM domain containing 3 -0.0297009
PCNX2 pecanex 2 -0.0295758
PUM2 pumilio RNA-binding family member 2 -0.02946
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0293869
ZBTB4 zinc finger and BTB domain containing 4 -0.0293024
LPP LIM domain containing preferred translocation partner in lipoma -0.029021
ATXN2 ataxin 2 -0.0289268
RBPMS RNA binding protein with multiple splicing -0.0289222
PDE8A phosphodiesterase 8A -0.0289051
MPRIP myosin phosphatase Rho interacting protein -0.0288827
FBXL20 F-box and leucine-rich repeat protein 20 -0.0288772
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0285729
ATOSA atos homolog A -0.0284185
DENND4A DENN/MADD domain containing 4A -0.0281234
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0280752
R3HDM2 R3H domain containing 2 -0.0280488
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0277406
ARF4 ADP-ribosylation factor 4 -0.0277219
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0276957
KANK1 KN motif and ankyrin repeat domains 1 -0.0274543
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0273857
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0272884
ACBD6 acyl-CoA binding domain containing 6 -0.0272646
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa -0.0272367
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0270204
ELMO1 engulfment and cell motility 1 -0.0269619
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0268578
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0268287
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0267554
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0266025
MAML2 mastermind-like 2 (Drosophila) -0.0265813
ELP4 elongator acetyltransferase complex subunit 4 -0.0265582
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 -0.0263606
SSH2 slingshot protein phosphatase 2 -0.0259931
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0259814
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -0.0259512
PDE7A phosphodiesterase 7A -0.0258296
CTSD cathepsin D -0.0256138
IGFBP4 insulin-like growth factor binding protein 4 -0.0255126
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0254969
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0253946
CCDC91 coiled-coil domain containing 91 -0.025357
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 -0.0251899
ESYT2 extended synaptotagmin-like protein 2 -0.0251496
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0251481
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0251025
SETD5 SET domain containing 5 -0.0247905
SMAD3 SMAD family member 3 -0.0247681
LAMA5 laminin, alpha 5 -0.0247602
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0243343
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0243004
ZNF638 zinc finger protein 638 -0.0242057
DPY19L1 dpy-19-like 1 (C. elegans) -0.0241686
GSPT1 G1 to S phase transition 1 -0.0240997
FBXW8 F-box and WD repeat domain containing 8 -0.0239608
ACTG1 actin gamma 1 -0.0239539
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0237803
C5 complement component 5 -0.0236575
WWOX WW domain containing oxidoreductase -0.0234456
SLC38A1 solute carrier family 38, member 1 -0.023208
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0230692
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) -0.0230192
HNRNPL heterogeneous nuclear ribonucleoprotein L -0.0229684
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 -0.0229179
PPP4R1 protein phosphatase 4, regulatory subunit 1 -0.0228099
SMAD2 SMAD family member 2 -0.0227456
METTL16 methyltransferase like 16 -0.0227054
RNF145 ring finger protein 145 -0.0226945
GOLM1 golgi membrane protein 1 -0.0225694
PCDH9 protocadherin 9 -0.0224205
JUP junction plakoglobin -0.0223583
RTN4RL2 reticulon 4 receptor-like 2 -0.0223577
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0223276
MBTD1 mbt domain containing 1 -0.0223013
CPT1A carnitine palmitoyltransferase 1A (liver) -0.022162
UCK2 uridine-cytidine kinase 2 -0.0221054
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 -0.0220809
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0220758
SREBF2 sterol regulatory element binding transcription factor 2 -0.0220521
SLC38A10 solute carrier family 38, member 10 -0.0219741
DIS3L2 DIS3 like 3'-5' exoribonuclease 2 -0.0219176
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0218723
S100A4 S100 calcium binding protein A4 -0.0217496
EZR ezrin -0.0217074
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type -0.0216368
KDM4C lysine (K)-specific demethylase 4C -0.0216081
ANKRD44 ankyrin repeat domain 44 -0.0215371
CDK12 cyclin-dependent kinase 12 -0.021429
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0213637
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 -0.0213532
LCLAT1 lysocardiolipin acyltransferase 1 -0.0212567
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.0211913
SIL1 SIL1 nucleotide exchange factor -0.0210864
BTBD7 BTB (POZ) domain containing 7 -0.0210272
SMG6 SMG6 nonsense mediated mRNA decay factor -0.0209903
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0209736
RNF34 ring finger protein 34, E3 ubiquitin protein ligase -0.0209235
WWC1 WW and C2 domain containing 1 -0.0209029
AHNAK AHNAK nucleoprotein -0.020828
ADAM17 ADAM metallopeptidase domain 17 -0.0207286
TRA2A transformer 2 alpha homolog (Drosophila) -0.0205289
RRP1B ribosomal RNA processing 1B -0.020511
CPNE8 copine VIII -0.0204599
AKAP9 A kinase (PRKA) anchor protein 9 -0.0204548
AVPI1 arginine vasopressin-induced 1 -0.0203174
M6PR mannose-6-phosphate receptor (cation dependent) -0.020299
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0202567
HACD2 3-hydroxyacyl-CoA dehydratase 2 -0.0202367
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0202354
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 -0.0201741
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0201041
TPM1 tropomyosin 1 (alpha) -0.0200924
NBEA neurobeachin -0.0200456
FHIT fragile histidine triad -0.0200265
FGG fibrinogen gamma chain -0.0200113
SAMD4B sterile alpha motif domain containing 4B -0.0200039
CHKA choline kinase alpha -0.0199871
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0198133
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0197882
CYSTM1 cysteine-rich transmembrane module containing 1 -0.0197391
FGB fibrinogen beta chain -0.0196892
INVS inversin -0.0196301
CDC27 cell division cycle 27 -0.019622
TSEN2 TSEN2 tRNA splicing endonuclease subunit -0.01958
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -0.0195612
RBMX RNA binding motif protein, X-linked -0.0195385
RAB5A RAB5A, member RAS oncogene family -0.019537
PHGDH phosphoglycerate dehydrogenase -0.0195362
PHACTR2 phosphatase and actin regulator 2 -0.0195258
TRIM37 tripartite motif containing 37 -0.0194846
KLHDC10 kelch domain containing 10 -0.0194609
B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 -0.0194348
PICALM phosphatidylinositol binding clathrin assembly protein -0.0194157
IRS2 insulin receptor substrate 2 -0.0193719
PGRMC1 progesterone receptor membrane component 1 -0.0193441
FAM193B family with sequence similarity 193, member B -0.0193172
POFUT3 protein O-fucosyltransferase 3 -0.019314
PRSS23 protease, serine, 23 -0.0192616
RARS1 arginyl-tRNA synthetase 1 -0.0192539
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0192461
SPG11 spastic paraplegia 11 (autosomal recessive) -0.0191686
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) -0.0191311
DPP8 dipeptidyl-peptidase 8 -0.0191217
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0190722
LAMB1 laminin, beta 1 -0.0190547
BAZ1B bromodomain adjacent to zinc finger domain, 1B -0.0190394
TOGARAM1 TOG array regulator of axonemal microtubules 1 -0.0190264
FGFR1 fibroblast growth factor receptor 1 -0.0189276
OLA1 Obg-like ATPase 1 -0.0189035
SINHCAF SIN3-HDAC complex associated factor -0.018857
RNF38 ring finger protein 38 -0.0188528
NCOR1 nuclear receptor corepressor 1 -0.0188424
MTCL1 microtubule crosslinking factor 1 -0.0188382
ELL2 elongation factor, RNA polymerase II, 2 -0.018831
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.01881
CLDN2 claudin 2 -0.018754
EXOC6B exocyst complex component 6B -0.0187036
TRERF1 transcriptional regulating factor 1 -0.0186991
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0186989
ZCCHC8 zinc finger, CCHC domain containing 8 -0.0185975
SCAMP2 secretory carrier membrane protein 2 -0.0185732
HM13 histocompatibility (minor) 13 -0.0185608
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -0.0185158
COMMD10 COMM domain containing 10 -0.0184817
STX8 syntaxin 8 -0.0184646
CDK17 cyclin-dependent kinase 17 -0.018437
TTC28 tetratricopeptide repeat domain 28 -0.0183966
HIP1 huntingtin interacting protein 1 -0.0183843
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0183327
FGD4 FYVE, RhoGEF and PH domain containing 4 -0.0182773
TMEM165 transmembrane protein 165 -0.0182478
USP9X ubiquitin specific peptidase 9, X-linked -0.0181684
P3H2 prolyl 3-hydroxylase 2 -0.0181504
SDCCAG8 serologically defined colon cancer antigen 8 -0.0180914
DUSP5 dual specificity phosphatase 5 -0.0180314
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 -0.0180231
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0180202
DNASE1L1 deoxyribonuclease I-like 1 -0.0179833
PLCL2 phospholipase C-like 2 -0.0179142
ADGRG6 adhesion G protein-coupled receptor G6 -0.0179099
ANKFY1 ankyrin repeat and FYVE domain containing 1 -0.0179035
PCYOX1 prenylcysteine oxidase 1 -0.0178538
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0178386
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0178024
ETF1 eukaryotic translation termination factor 1 -0.0177636
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) -0.0177105
SLTM SAFB-like, transcription modulator -0.0177092
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0176611
EML2 echinoderm microtubule associated protein like 2 -0.0175922
IGSF11 immunoglobulin superfamily, member 11 -0.0175533
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 -0.0175346
PHKA2 phosphorylase kinase, alpha 2 (liver) -0.0174502
TFCP2 transcription factor CP2 -0.0172541
FHL2 four and a half LIM domains 2 -0.0172156
GOLGA4 golgin A4 -0.017196
GEN1 GEN1 Holliday junction 5' flap endonuclease -0.0171857
FTO fat mass and obesity associated -0.0171077
SHTN1 shootin 1 -0.017057
SREBF1 sterol regulatory element binding transcription factor 1 -0.0170408
CCNYL1 cyclin Y-like 1 -0.0170199
PATJ PATJ crumbs cell polarity complex component -0.0169989
LRRK2 leucine-rich repeat kinase 2 -0.0169818
CFH complement factor H -0.016963
SLIT3 slit homolog 3 (Drosophila) -0.0169525
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0169276
FILIP1 filamin A interacting protein 1 -0.0168979
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 -0.0168847
SKAP2 src kinase associated phosphoprotein 2 -0.0168789
ANXA11 annexin A11 -0.0168507
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like -0.0168416
GTF2IRD1 GTF2I repeat domain containing 1 -0.0168178
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 -0.0167674
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0167611
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0167138
UNK unkempt family zinc finger -0.0166888
PRPF8 pre-mRNA processing factor 8 -0.016643
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) -0.016633
GPR39 G protein-coupled receptor 39 -0.0166139
WAC WW domain containing adaptor with coiled-coil -0.0165972
NME7 NME/NM23 family member 7 -0.0165922
THRB thyroid hormone receptor, beta -0.0165638
GMDS GDP-mannose 4,6-dehydratase -0.0165083
ETNK1 ethanolamine kinase 1 -0.016458
FCHSD2 FCH and double SH3 domains 2 -0.0164468
TAPBP TAP binding protein (tapasin) -0.0164451
OFD1 oral-facial-digital syndrome 1 -0.0164395
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa -0.0164186
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -0.0163687
FBXW11 F-box and WD repeat domain containing 11 -0.0163485
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 -0.016327
DIPK1A divergent protein kinase domain 1A -0.0163262
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.0162973
LIMD1 LIM domains containing 1 -0.0162973
ACACA acetyl-CoA carboxylase alpha -0.0162752
NBR1 neighbor of BRCA1 gene 1 -0.0162577
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0162359
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog -0.0162186
DPY19L3 dpy-19-like 3 (C. elegans) -0.016179
BICRAL BICRA like chromatin remodeling complex associated protein -0.0161442
NBEAL1 neurobeachin-like 1 -0.0161003
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.01608
VIM vimentin -0.0160592
TACC2 transforming, acidic coiled-coil containing protein 2 -0.0160537
RABGAP1L RAB GTPase activating protein 1-like -0.0160481
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0160253
FMN1 formin 1 -0.015971
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0159399
PMM2 phosphomannomutase 2 -0.015909
MACROD2 MACRO domain containing 2 -0.0158988
FRK fyn-related Src family tyrosine kinase -0.0158677
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -0.0158525
PDXK pyridoxal (pyridoxine, vitamin B6) kinase -0.015823
PRKCSH protein kinase C substrate 80K-H -0.015789
FBXL18 F-box and leucine-rich repeat protein 18 -0.0157679
PDZD8 PDZ domain containing 8 -0.015748
KMT2D lysine (K)-specific methyltransferase 2D -0.0157369
PLD5 phospholipase D family, member 5 -0.015736
NLGN4Y neuroligin 4, Y-linked -0.0157062
TPCN1 two pore segment channel 1 -0.0157047
COG4 component of oligomeric golgi complex 4 -0.0156603
TMC5 transmembrane channel-like 5 -0.0156588
UBAP2L ubiquitin associated protein 2-like -0.0155794
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 -0.0155585
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -0.015511
NMT1 N-myristoyltransferase 1 -0.0154702
RORA RAR-related orphan receptor A -0.015423
ERBB3 erb-b2 receptor tyrosine kinase 3 -0.0154137
ETFA electron-transfer-flavoprotein, alpha polypeptide -0.0154084
RNF220 ring finger protein 220 -0.0153341
BCLAF1 BCL2-associated transcription factor 1 -0.0153164
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0152987
USP34 ubiquitin specific peptidase 34 -0.0152892
ZNF207 zinc finger protein 207 -0.0152673
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.015258
AFF4 AF4/FMR2 family, member 4 -0.0152547
ARHGAP18 Rho GTPase activating protein 18 -0.0152096
CCDC47 coiled-coil domain containing 47 -0.0152051
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 -0.0152041
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0152013
IL6ST interleukin 6 signal transducer -0.0151531
KLHL15 kelch-like family member 15 -0.0151127
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16 -0.01508
EIF2A eukaryotic translation initiation factor 2A, 65kDa -0.0150791
IQCB1 IQ motif containing B1 -0.0150497
KIAA1671 KIAA1671 -0.0150313
TFG TRK-fused gene -0.0150229
TGFBR1 transforming growth factor, beta receptor 1 -0.0150129
KLHL5 kelch-like family member 5 -0.0150013
CACUL1 CDK2-associated, cullin domain 1 -0.0149902
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0149889
PDIA5 protein disulfide isomerase family A, member 5 -0.0149842
CD109 CD109 molecule -0.0149588
OTUD5 OTU deubiquitinase 5 -0.0149378
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0148794
IPO7 importin 7 -0.0148686
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0148596
CEBPZOS CEBPZ opposite strand -0.0148339
RNF10 ring finger protein 10 -0.0148331
COPE coatomer protein complex, subunit epsilon -0.0148294
MYO10 myosin X -0.0147894
PHC3 polyhomeotic homolog 3 (Drosophila) -0.0147867
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0147333
TFF1 trefoil factor 1 -0.0147263
ZNF148 zinc finger protein 148 -0.0147105
CALU calumenin -0.0146644
NECTIN2 nectin cell adhesion molecule 2 -0.0146331
CDC123 cell division cycle 123 -0.0146328
TPM4 tropomyosin 4 -0.0146039
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.0146001
SOCS6 suppressor of cytokine signaling 6 -0.014578
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0145651
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 -0.0145615
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0145522
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0145176
BLTP3A bridge-like lipid transfer protein family member 3A -0.0145145
RNF41 ring finger protein 41, E3 ubiquitin protein ligase -0.014501
TTLL6 tubulin tyrosine ligase-like family member 6 -0.0144831
TMEM135 transmembrane protein 135 -0.0144782
GDF15 growth differentiation factor 15 -0.014477
SRPK2 SRSF protein kinase 2 -0.0144729
TNRC18 trinucleotide repeat containing 18 -0.0144619
RBM6 RNA binding motif protein 6 -0.0144493
SCARB1 scavenger receptor class B, member 1 -0.0144154
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0144093
MAP2K4 mitogen-activated protein kinase kinase 4 -0.0143927
ATAD1 ATPase family, AAA domain containing 1 -0.014377
KTN1 kinectin 1 (kinesin receptor) -0.0142849
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5 -0.0142632
IP6K2 inositol hexakisphosphate kinase 2 -0.0142447
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 -0.0142237
NR1D2 nuclear receptor subfamily 1, group D, member 2 -0.0141748
RASA2 RAS p21 protein activator 2 -0.0141595
KDM6A lysine (K)-specific demethylase 6A -0.0141562
PTBP1 polypyrimidine tract binding protein 1 -0.0141401
ANTXR1 anthrax toxin receptor 1 -0.0141247
KIF13A kinesin family member 13A -0.0141079
HEXB hexosaminidase B (beta polypeptide) -0.0140653
TENT4B terminal nucleotidyltransferase 4B -0.0140629
WARS1 tryptophanyl-tRNA synthetase 1 -0.0140327
TGIF1 TGFB-induced factor homeobox 1 -0.0140276
ZFR zinc finger RNA binding protein -0.0140259
WDFY3 WD repeat and FYVE domain containing 3 -0.0140238
CLASP2 cytoplasmic linker associated protein 2 -0.0139802
NUP153 nucleoporin 153kDa -0.0139801
CDHR3 cadherin-related family member 3 -0.0139675
CGGBP1 CGG triplet repeat binding protein 1 -0.0139406
KAT6B K(lysine) acetyltransferase 6B -0.0139262
DZIP1 DAZ interacting zinc finger protein 1 -0.0139111
TASP1 taspase, threonine aspartase, 1 -0.0139083
FER fer (fps/fes related) tyrosine kinase -0.0139075
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a -0.0139022
RFX3 regulatory factor X, 3 (influences HLA class II expression) -0.0138946
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0138534
BRD7 bromodomain containing 7 -0.0138493
EPM2AIP1 EPM2A (laforin) interacting protein 1 -0.0138294
ANKRD12 ankyrin repeat domain 12 -0.0138271
YIPF4 Yip1 domain family, member 4 -0.0138225
DNA2 DNA replication helicase/nuclease 2 -0.0137499
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 -0.0137382
CPSF3 cleavage and polyadenylation specific factor 3, 73kDa -0.01369
MON2 MON2 homolog (S. cerevisiae) -0.0136756
FBXL2 F-box and leucine-rich repeat protein 2 -0.013645
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H -0.0136437
MAGT1 magnesium transporter 1 -0.0136248
SPAG9 sperm associated antigen 9 -0.0136177
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 -0.0135955
LMAN2 lectin, mannose-binding 2 -0.0135943
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 -0.0135542
AKR1C3 aldo-keto reductase family 1, member C3 -0.0135532
THEM4 thioesterase superfamily member 4 -0.0135434
CEP295 centrosomal protein 295kDa -0.0135413
REV1 REV1, polymerase (DNA directed) -0.0135043
NSD3 nuclear receptor binding SET domain protein 3 -0.0134901
GPHN gephyrin -0.0134722
CREB3L2 cAMP responsive element binding protein 3-like 2 -0.0134698
RASAL2 RAS protein activator like 2 -0.0134696
PARD6B par-6 family cell polarity regulator beta -0.0134398
SMAD6 SMAD family member 6 -0.0134216
TCF12 transcription factor 12 -0.0134132
GNA12 guanine nucleotide binding protein (G protein) alpha 12 -0.0134105
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 -0.0134067
RUFY2 RUN and FYVE domain containing 2 -0.0134024
KDM5A lysine (K)-specific demethylase 5A -0.0133802
PBX3 pre-B-cell leukemia homeobox 3 -0.013356
SYAP1 synapse associated protein 1 -0.0133514
TRAK1 trafficking protein, kinesin binding 1 -0.0133508
CMC2 C-x(9)-C motif containing 2 -0.0133465
FAM234A family with sequence similarity 234 member A -0.0133408
LAPTM4A lysosomal protein transmembrane 4 alpha -0.0133337
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0133252
RBM25 RNA binding motif protein 25 -0.0133247
CCNY cyclin Y -0.013319
TBCD tubulin folding cofactor D -0.0132938
CTPS1 CTP synthase 1 -0.0132784
ECPAS Ecm29 proteasome adaptor and scaffold -0.0132292
PON2 paraoxonase 2 -0.0131957
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.0131777
CCAR1 cell division cycle and apoptosis regulator 1 -0.0131634
INSR insulin receptor -0.0131539
CARMIL1 capping protein regulator and myosin 1 linker 1 -0.0131521
ECE1 endothelin converting enzyme 1 -0.0131239
SEC24C SEC24 family member C -0.0131079
ATP7A ATPase, Cu++ transporting, alpha polypeptide -0.0130886
BNC2 basonuclin 2 -0.0130861
PPP1R21 protein phosphatase 1, regulatory subunit 21 -0.0130849