A549_Alendronate sodium trihydrate_10nM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description Alendronate sodium trihydrate 10nM perturbation in A549 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the A549_Alendronate sodium trihydrate_10nM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide 0.112109
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.110098
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.081279
KPNB1 karyopherin (importin) beta 1 0.0794621
AKR1C3 aldo-keto reductase family 1, member C3 0.0785232
FTH1 ferritin, heavy polypeptide 1 0.0769309
AGR2 anterior gradient 2 0.0737832
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0728446
ENO1 enolase 1, (alpha) 0.0698212
FLNB filamin B, beta 0.0691466
MUSK muscle, skeletal, receptor tyrosine kinase 0.0680739
PCYOX1 prenylcysteine oxidase 1 0.0677731
ANXA1 annexin A1 0.0628783
CENPF centromere protein F, 350/400kDa 0.0627337
PRRC2C proline-rich coiled-coil 2C 0.058737
ALCAM activated leukocyte cell adhesion molecule 0.0577604
MKI67 marker of proliferation Ki-67 0.0566688
NPAS2 neuronal PAS domain protein 2 0.0545447
CENPP centromere protein P 0.0541115
AKR1C2 aldo-keto reductase family 1, member C2 0.0522109
RPL8 ribosomal protein L8 0.0513933
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.05066
RPS6 ribosomal protein S6 0.0504689
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0490315
KRT8 keratin 8, type II 0.0484814
GCLC glutamate-cysteine ligase, catalytic subunit 0.0484793
MAP7 microtubule-associated protein 7 0.0482345
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0479576
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0472912
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0467964
CEP128 centrosomal protein 128kDa 0.0458823
KRT18 keratin 18, type I 0.0455052
FANCA Fanconi anemia, complementation group A 0.0449613
NIPBL Nipped-B homolog (Drosophila) 0.0441594
UGDH UDP-glucose 6-dehydrogenase 0.0437927
BRCA1 breast cancer 1, early onset 0.0437778
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 0.0437378
TGOLN2 trans-golgi network protein 2 0.043675
BSG basigin (Ok blood group) 0.0436367
ACACA acetyl-CoA carboxylase alpha 0.0435428
PLEC plectin 0.0429516
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0428833
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0417755
RPS8 ribosomal protein S8 0.0411868
TM4SF1 transmembrane 4 L six family member 1 0.0410112
UBL4A ubiquitin-like 4A 0.040219
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0397709
TACC1 transforming, acidic coiled-coil containing protein 1 0.0392331
ITFG1 integrin alpha FG-GAP repeat containing 1 0.0389697
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0383088
MGST1 microsomal glutathione S-transferase 1 0.0377423
TBC1D5 TBC1 domain family, member 5 0.037696
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0370914
STK24 serine/threonine kinase 24 0.0370023
CLU clusterin 0.036429
CALR calreticulin 0.0363872
CCT7 chaperonin containing TCP1, subunit 7 (eta) 0.0362693
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0358376
DHDDS dehydrodolichyl diphosphate synthase 0.0357477
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0353194
RPS2 ribosomal protein S2 0.035013
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0346664
TPM3 tropomyosin 3 0.0342928
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0342812
EXOC6B exocyst complex component 6B 0.034235
NAP1L4 nucleosome assembly protein 1-like 4 0.0342028
SETD5 SET domain containing 5 0.0340922
STRN3 striatin, calmodulin binding protein 3 0.0338162
RSF1 remodeling and spacing factor 1 0.0335891
STAG2 stromal antigen 2 0.0335332
RPL37A ribosomal protein L37a 0.0334072
ECT2 epithelial cell transforming 2 0.0334003
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2 0.0329111
RPS17 ribosomal protein S17 0.0323832
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0323178
RRBP1 ribosome binding protein 1 0.0322079
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0321936
MAP1B microtubule-associated protein 1B 0.0321927
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0321898
ZSWIM6 zinc finger, SWIM-type containing 6 0.0321141
ZNF367 zinc finger protein 367 0.032001
CDC42SE2 CDC42 small effector 2 0.0319135
NCAPG2 non-SMC condensin II complex, subunit G2 0.0317972
ARHGAP11A Rho GTPase activating protein 11A 0.0316476
PTMS parathymosin 0.0316375
RPLP2 ribosomal protein, large, P2 0.0314186
SH3D19 SH3 domain containing 19 0.0314004
SCFD2 sec1 family domain containing 2 0.0313167
CLDN2 claudin 2 0.0310326
PRELID2 PRELI domain containing 2 0.0309741
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0309074
TMSB10 thymosin beta 10 0.0308698
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0306799
ASPH aspartate beta-hydroxylase 0.0304674
RPS3 ribosomal protein S3 0.030164
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0300877
MMS22L MMS22-like, DNA repair protein 0.0299689
SMAD3 SMAD family member 3 0.0294978
EXT1 exostosin glycosyltransferase 1 0.0293878
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 0.0291957
EIF5B eukaryotic translation initiation factor 5B 0.0291671
SMC4 structural maintenance of chromosomes 4 0.0291451
VDAC1 voltage-dependent anion channel 1 0.0290478
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.028852
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0288222
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0288104
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0286865
PIGL phosphatidylinositol glycan anchor biosynthesis, class L 0.0286817
HMGA1 high mobility group AT-hook 1 0.0284696
RPL38 ribosomal protein L38 0.0284261
RPL30 ribosomal protein L30 0.0284024
SCARB1 scavenger receptor class B, member 1 0.0282639
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0281705
KIF5B kinesin family member 5B 0.0281114
ITGB5 integrin, beta 5 0.0280387
PRRC2B proline-rich coiled-coil 2B 0.0279554
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 0.0278898
SUZ12 SUZ12 polycomb repressive complex 2 subunit 0.0277512
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.027664
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0276097
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0275329
TMPO thymopoietin 0.0274125
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.0272254
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.027129
PDE7B phosphodiesterase 7B 0.0268254
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0268182
PTGES2 prostaglandin E synthase 2 0.0267411
ARRB1 arrestin, beta 1 0.026708
AFAP1 actin filament associated protein 1 0.0266392
TBC1D4 TBC1 domain family, member 4 0.0266011
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 0.0265872
FAF1 Fas (TNFRSF6) associated factor 1 0.0265852
LMNA lamin A/C 0.0265541
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0265265
GCLM glutamate-cysteine ligase, modifier subunit 0.0261683
RTTN rotatin 0.0260833
DENND1B DENN/MADD domain containing 1B 0.0260241
MYADM myeloid-associated differentiation marker 0.0258182
SFXN1 sideroflexin 1 0.0258139
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0257919
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.0257492
SRBD1 S1 RNA binding domain 1 0.0256597
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0253497
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 0.0253382
TRIM37 tripartite motif containing 37 0.0251712
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0251547
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0251239
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.0250996
RPL37 ribosomal protein L37 0.0250823
SBF2 SET binding factor 2 0.02507
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0249396
PPME1 protein phosphatase methylesterase 1 0.0248202
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.0247844
POLK polymerase (DNA directed) kappa 0.0247729
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0247574
TKT transketolase 0.0245817
ATXN2 ataxin 2 0.0244738
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 0.0243899
LASP1 LIM and SH3 protein 1 0.0243513
IRS2 insulin receptor substrate 2 0.0243469
ATRN attractin 0.0241023
METTL2A methyltransferase like 2A 0.0240817
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.0240512
ANLN anillin, actin binding protein 0.0239941
RBBP6 retinoblastoma binding protein 6 0.0239742
CKAP5 cytoskeleton associated protein 5 0.0239676
RBMS2 RNA binding motif, single stranded interacting protein 2 0.0239111
MED14 mediator complex subunit 14 0.0237561
CLTC clathrin, heavy chain (Hc) 0.0236679
ZNFX1 zinc finger, NFX1-type containing 1 0.0236202
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0235583
R3HDM1 R3H domain containing 1 0.0235488
SYNJ2 synaptojanin 2 0.0235185
ARHGAP11B Rho GTPase activating protein 11B 0.0234224
CANX calnexin 0.0233966
DENND4C DENN/MADD domain containing 4C 0.0233265
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 0.0231877
SH3KBP1 SH3-domain kinase binding protein 1 0.0231773
PA2G4 proliferation-associated 2G4, 38kDa 0.0231772
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0229871
DIS3L2 DIS3 like 3'-5' exoribonuclease 2 0.0229468
CLASP1 cytoplasmic linker associated protein 1 0.0228889
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 0.0228465
RAB33B RAB33B, member RAS oncogene family 0.0227828
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0225629
NUDCD3 NudC domain containing 3 0.0225426
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 0.0225256
KIF18B kinesin family member 18B 0.0224928
ACIN1 apoptotic chromatin condensation inducer 1 0.0224472
PRIM2 primase, DNA, polypeptide 2 (58kDa) 0.0224265
TMEM165 transmembrane protein 165 0.0223637
SF3A3 splicing factor 3a, subunit 3, 60kDa 0.0223571
CRYBG3 beta-gamma crystallin domain containing 3 0.0223151
SNRPA small nuclear ribonucleoprotein polypeptide A 0.0222713
FADS2 fatty acid desaturase 2 0.0222701
SRPK2 SRSF protein kinase 2 0.0220144
KIF21A kinesin family member 21A 0.0218713
KIF20B kinesin family member 20B 0.0218267
LDHA lactate dehydrogenase A 0.0217753
TMTC3 transmembrane and tetratricopeptide repeat containing 3 0.0217717
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0217636
PRKCA protein kinase C, alpha 0.0217198
CLIP1 CAP-GLY domain containing linker protein 1 0.0217071
HEATR1 HEAT repeat containing 1 0.021601
UBE2R2 ubiquitin-conjugating enzyme E2R 2 0.0215581
CLIC1 chloride intracellular channel 1 0.0215169
ZRANB3 zinc finger, RAN-binding domain containing 3 0.0215066
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0213991
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0213591
NCAPD2 non-SMC condensin I complex, subunit D2 0.0213543
SLX4IP SLX4 interacting protein 0.0212876
AK1 adenylate kinase 1 0.0212641
MORC4 MORC family CW-type zinc finger 4 0.0212516
RUVBL2 RuvB-like AAA ATPase 2 0.0212452
YIF1B Yip1 interacting factor homolog B (S. cerevisiae) 0.0212354
RPL39 ribosomal protein L39 0.0211584
ANKRD26 ankyrin repeat domain 26 0.0211238
MED13L mediator complex subunit 13-like 0.0210816
TTC17 tetratricopeptide repeat domain 17 0.0210718
CENPM centromere protein M 0.0210712
NUSAP1 nucleolar and spindle associated protein 1 0.0210091
FKBP3 FK506 binding protein 3, 25kDa 0.020985
BCOR BCL6 corepressor 0.0209014
MARCHF6 membrane associated ring-CH-type finger 6 0.0208807
SIK3 SIK family kinase 3 0.020879
CTTN cortactin 0.0207842
PCBD2 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 0.020755
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) 0.0207156
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 0.0206945
UBASH3B ubiquitin associated and SH3 domain containing B 0.0206429
FAM120A family with sequence similarity 120A 0.0206261
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0205464
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0205286
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 0.0205271
LOC112694756 uncharaterized LOC112694756 0.0205005
PDIA3 protein disulfide isomerase family A, member 3 0.0204674
DAD1 defender against cell death 1 0.0204433
EPAS1 endothelial PAS domain protein 1 0.0203874
TMEM131 transmembrane protein 131 0.0203855
ATP5F1B ATP synthase F1 subunit beta 0.020378
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0203778
TMCC1 transmembrane and coiled-coil domain family 1 0.0203744
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0203053
NRCAM neuronal cell adhesion molecule 0.0202556
ATL3 atlastin GTPase 3 0.0202439
TET3 tet methylcytosine dioxygenase 3 0.0202003
CIZ1 CDKN1A interacting zinc finger protein 1 0.0201143
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0200762
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0200701
CREB1 cAMP responsive element binding protein 1 0.0200217
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 0.0199854
KIF14 kinesin family member 14 0.0199705
AARS1 alanyl-tRNA synthetase 1 0.0199618
NUP98 nucleoporin 98kDa 0.0199597
AAK1 AP2 associated kinase 1 0.0199521
CTBP2 C-terminal binding protein 2 0.019948
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0199353
PTPN9 protein tyrosine phosphatase, non-receptor type 9 0.0199032
JARID2 jumonji, AT rich interactive domain 2 0.0199032
CHD1 chromodomain helicase DNA binding protein 1 0.0198856
ACTG1 actin gamma 1 0.019852
MRPS23 mitochondrial ribosomal protein S23 0.0198345
CENPE centromere protein E, 312kDa 0.0197928
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa 0.0197882
MTREX Mtr4 exosome RNA helicase 0.0197728
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0197696
DIAPH1 diaphanous-related formin 1 0.0197272
SMC1A structural maintenance of chromosomes 1A 0.0197186
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0197159
CCDC47 coiled-coil domain containing 47 0.0196415
MAVS mitochondrial antiviral signaling protein 0.0196204
PBRM1 polybromo 1 0.0195822
MAGED1 melanoma antigen family D1 0.019522
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa 0.0195204
NOP58 NOP58 ribonucleoprotein 0.0195127
CHD3 chromodomain helicase DNA binding protein 3 0.0194554
RPLP0 ribosomal protein, large, P0 0.0193292
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 0.019311
DARS1 aspartyl-tRNA synthetase 1 0.0193081
WDFY2 WD repeat and FYVE domain containing 2 0.0192621
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 0.0192558
PLD5 phospholipase D family, member 5 0.0192322
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0192235
SYNGAP1 synaptic Ras GTPase activating protein 1 0.019202
FBXW8 F-box and WD repeat domain containing 8 0.0192012
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase 0.0191848
DNM1L dynamin 1-like 0.0191819
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 0.0191476
AKR1C1 aldo-keto reductase family 1, member C1 0.0191277
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0191182
RHOC ras homolog family member C 0.0190342
SFPQ splicing factor proline/glutamine-rich 0.0190269
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 0.0189871
DPEP2 dipeptidase 2 0.0188059
CADM1 cell adhesion molecule 1 0.0187986
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0187943
WNK1 WNK lysine deficient protein kinase 1 0.018745
GRB2 growth factor receptor-bound protein 2 0.0187158
CA12 carbonic anhydrase XII 0.0186921
REEP3 receptor accessory protein 3 0.0186904
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0186867
VCP valosin containing protein 0.0186352
CTCF CCCTC-binding factor (zinc finger protein) 0.0186333
TTC23 tetratricopeptide repeat domain 23 0.0185878
GRAMD1B GRAM domain containing 1B 0.0185278
NIN ninein (GSK3B interacting protein) 0.0185094
ZC3HC1 zinc finger, C3HC-type containing 1 0.0184916
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 0.0184784
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 0.0184771
AREG amphiregulin 0.0184503
IDS iduronate 2-sulfatase 0.0184336
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0184267
EEA1 early endosome antigen 1 0.0184248
CERT1 ceramide transporter 1 0.0184011
SNRPA1 small nuclear ribonucleoprotein polypeptide A' 0.0183946
MYO9B myosin IXB 0.0183234
BBX bobby sox homolog (Drosophila) 0.0182017
PEAK1 pseudopodium-enriched atypical kinase 1 0.0181255
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G 0.0180907
CMTM8 CKLF-like MARVEL transmembrane domain containing 8 0.0180751
YJU2B YJU2 splicing factor homolog B 0.0180659
ABTB3 ankyrin repeat and BTB domain containing 3 0.0179876
SH3PXD2B SH3 and PX domains 2B 0.0179829
MPHOSPH6 M-phase phosphoprotein 6 0.0179288
CPLX2 complexin 2 0.0179171
KTN1 kinectin 1 (kinesin receptor) 0.0179054
NOPCHAP1 NOP protein chaperone 1 0.0179021
NCKAP1 NCK-associated protein 1 0.0178834
MTCL1 microtubule crosslinking factor 1 0.0178558
USP40 ubiquitin specific peptidase 40 0.0178547
MRPL20 mitochondrial ribosomal protein L20 0.0178416
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 0.0177861
TLR6 toll-like receptor 6 0.0177399
RARB retinoic acid receptor, beta 0.0177119
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0176761
USP37 ubiquitin specific peptidase 37 0.0176251
IDE insulin-degrading enzyme 0.0176211
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 0.0176133
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0175998
MNX1 motor neuron and pancreas homeobox 1 0.0175905
SNX29 sorting nexin 29 0.0175762
SMOX spermine oxidase 0.0175447
NCOA2 nuclear receptor coactivator 2 0.0175302
MYEOV myeloma overexpressed 0.0175237
SUMO1 small ubiquitin-like modifier 1 0.0175106
BLTP2 bridge-like lipid transfer protein family member 2 0.0174711
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa 0.0174508
PIGS phosphatidylinositol glycan anchor biosynthesis, class S 0.0174071
SFI1 Sfi1 homolog, spindle assembly associated (yeast) 0.0173634
RAD21 RAD21 homolog (S. pombe) 0.0173537
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 0.017294
HDGF hepatoma-derived growth factor 0.0172933
PBK PDZ binding kinase 0.0172847
ASF1B anti-silencing function 1B histone chaperone 0.0172697
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa 0.0172657
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0172207
PUM3 pumilio RNA binding family member 3 0.0171814
NSRP1 nuclear speckle splicing regulatory protein 1 0.0171628
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) 0.0171535
CCT4 chaperonin containing TCP1, subunit 4 (delta) 0.0171528
AP2S1 adaptor-related protein complex 2, sigma 1 subunit 0.0171194
ASTN2 astrotactin 2 0.0170823
RPS14 ribosomal protein S14 0.0170421
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 0.017038
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.0170209
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0170125
RFWD3 ring finger and WD repeat domain 3 0.0170107
ZC3H7A zinc finger CCCH-type containing 7A 0.0170028
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.0170006
MICU1 mitochondrial calcium uptake 1 0.0169692
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0168923
GMPS guanine monphosphate synthase 0.0168828
SMNDC1 survival motor neuron domain containing 1 0.016836
ZDHHC5 zinc finger, DHHC-type containing 5 0.0168005
AURKA aurora kinase A 0.0167928
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0167542
LRRC20 leucine rich repeat containing 20 0.0167524
TEX10 testis expressed 10 0.0167307
CKAP4 cytoskeleton-associated protein 4 0.0167037
TMX2 thioredoxin-related transmembrane protein 2 0.0166838
NXPE3 neurexophilin and PC-esterase domain family, member 3 0.0166585
USP54 ubiquitin specific peptidase 54 0.0166056
PLCD3 phospholipase C, delta 3 0.0166018
TANGO6 transport and golgi organization 6 homolog (Drosophila) 0.0165286
ARL4C ADP-ribosylation factor-like 4C 0.0165253
DOCK10 dedicator of cytokinesis 10 0.0164806
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) 0.0164755
PROS1 protein S (alpha) 0.0164748
MPZL1 myelin protein zero-like 1 0.0164691
RNF217 ring finger protein 217 0.0164064
ELOB elongin B 0.016373
WDHD1 WD repeat and HMG-box DNA binding protein 1 0.0163499
KAT6B K(lysine) acetyltransferase 6B 0.0163353
CEP152 centrosomal protein 152kDa 0.0163318
REPS1 RALBP1 associated Eps domain containing 1 0.0163198
TBC1D16 TBC1 domain family, member 16 0.0162989
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 0.0162856
SET SET nuclear proto-oncogene 0.0162781
MASTL microtubule associated serine/threonine kinase-like 0.0162762
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 0.0162488
FUCA2 fucosidase, alpha-L- 2, plasma 0.0162362
SLC35A4 solute carrier family 35, member A4 0.0162233
SLMAP sarcolemma associated protein 0.0162091
RPL27A ribosomal protein L27a 0.0162022
ABLIM1 actin binding LIM protein 1 0.016176
EIF3B eukaryotic translation initiation factor 3, subunit B 0.0161631
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0161621
HGD homogentisate 1,2-dioxygenase 0.0161593
DCP1A decapping mRNA 1A 0.0161116
MAML2 mastermind-like 2 (Drosophila) 0.0161097
SLC38A10 solute carrier family 38, member 10 0.0161008
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 0.0160577
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0159729
GPATCH2L G patch domain containing 2-like 0.0159548
H1-10 H1.10 linker histone 0.0159388
GPBP1 GC-rich promoter binding protein 1 0.0159298
TUBA1B tubulin, alpha 1b 0.015811
EML1 echinoderm microtubule associated protein like 1 0.0158037
PTMA prothymosin, alpha 0.015775
ANAPC10 anaphase promoting complex subunit 10 0.0157326
CEP120 centrosomal protein 120kDa 0.0156891
PRR11 proline rich 11 0.0156804
TLN1 talin 1 0.015645
ZFAND3 zinc finger, AN1-type domain 3 0.0156396
SREBF1 sterol regulatory element binding transcription factor 1 0.0156026
DEK DEK proto-oncogene 0.0155899
TMEM97 transmembrane protein 97 0.0155361
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.0155254
STOM stomatin 0.0154901
RNASE3 ribonuclease, RNase A family, 3 0.0154092
DOCK7 dedicator of cytokinesis 7 0.0153978
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0153823
CXXC1 CXXC finger protein 1 0.0153603
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0153562
FBH1 F-box DNA helicase 1 0.0153052
RPS4X ribosomal protein S4, X-linked 0.0152826
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0152711
LARS2 leucyl-tRNA synthetase 2, mitochondrial 0.0152603
AMBRA1 autophagy/beclin-1 regulator 1 0.0152599
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0152562
PITPNB phosphatidylinositol transfer protein, beta 0.0152396
UCK2 uridine-cytidine kinase 2 0.015229
LIMCH1 LIM and calponin homology domains 1 0.0152197
HSPB1 heat shock 27kDa protein 1 0.0152072
FBXO11 F-box protein 11 0.0151996
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 0.0151978
PIR pirin (iron-binding nuclear protein) 0.0151392
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.0150964
TGIF1 TGFB-induced factor homeobox 1 0.0150627
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4 0.015062
AFDN afadin, adherens junction formation factor 0.0150431
SLF1 SMC5-SMC6 complex localization factor 1 0.0150258
KMT2C lysine (K)-specific methyltransferase 2C 0.0150219
SYNGR2 synaptogyrin 2 0.0150209
MPZ myelin protein zero 0.0149883
NIPSNAP2 nipsnap homolog 2 0.014977
LRPPRC leucine-rich pentatricopeptide repeat containing 0.014964
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0149575
DIDO1 death inducer-obliterator 1 0.0149529
GOLGB1 golgin B1 0.0149279
MIA3 melanoma inhibitory activity family, member 3 0.0149068
TBC1D2B TBC1 domain family, member 2B 0.0148986
TGFBRAP1 transforming growth factor, beta receptor associated protein 1 0.0148874
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0148851
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0148497
INVS inversin 0.0148355
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 0.0148325
TNPO1 transportin 1 0.0148277
JAG1 jagged 1 0.0148111
S100PBP S100P binding protein 0.0148109
PSME3IP1 proteasome activator subunit 3 interacting protein 1 0.0148
UBE2D2 ubiquitin-conjugating enzyme E2D 2 0.0147833
ATL2 atlastin GTPase 2 0.0147766
UBTD2 ubiquitin domain containing 2 0.0147671
ATP5F1A ATP synthase F1 subunit alpha 0.0147495
ZFP91 ZFP91 zinc finger protein 0.0147276
SSRP1 structure specific recognition protein 1 0.0147173
ZNF721 zinc finger protein 721 0.0147138
ANKRD13D ankyrin repeat domain 13 family, member D 0.014688
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1 0.0146567
MSL2 male-specific lethal 2 homolog (Drosophila) 0.0146533
CNST consortin, connexin sorting protein 0.0145986
RYK receptor-like tyrosine kinase 0.0145972
CCDC138 coiled-coil domain containing 138 0.0145963
GNS glucosamine (N-acetyl)-6-sulfatase 0.0145815
PANK3 pantothenate kinase 3 0.0145146
FLNA filamin A, alpha 0.014493
IP6K1 inositol hexakisphosphate kinase 1 0.0144849
ATAD5 ATPase family, AAA domain containing 5 0.0144743
CRTAP cartilage associated protein 0.0144627
NOP56 NOP56 ribonucleoprotein 0.0144394
PIGT phosphatidylinositol glycan anchor biosynthesis, class T 0.0144377
DENND1A DENN/MADD domain containing 1A 0.0144337
SF3B6 splicing factor 3b, subunit 6, 14kDa 0.0144278
WDFY1 WD repeat and FYVE domain containing 1 0.0144205
EXOSC5 exosome component 5 0.0144013
EIF5 eukaryotic translation initiation factor 5 0.014388
COPE coatomer protein complex, subunit epsilon 0.0143593
B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 0.0143505
EPDR1 ependymin related 1 0.0143114

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.10735
KYNU kynureninase -0.0745969
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0729493
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0728204
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.072108
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0706125
TPM4 tropomyosin 4 -0.0635632
ZBTB20 zinc finger and BTB domain containing 20 -0.0634843
ARHGAP26 Rho GTPase activating protein 26 -0.062741
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.0627236
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0603534
GPATCH8 G patch domain containing 8 -0.057161
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0532824
BMPR1B bone morphogenetic protein receptor, type IB -0.0531645
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0517572
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) -0.0508483
CUX1 cut-like homeobox 1 -0.0507605
CNTNAP3B contactin associated protein-like 3B -0.0498676
NRG1 neuregulin 1 -0.0497241
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.0496306
IGF1R insulin-like growth factor 1 receptor -0.0486093
SPIDR scaffolding protein involved in DNA repair -0.0480107
FN1 fibronectin 1 -0.0468391
TXNRD1 thioredoxin reductase 1 -0.0468369
UBA2 ubiquitin-like modifier activating enzyme 2 -0.0465569
LRMDA leucine rich melanocyte differentiation associated -0.0454203
IGFBP4 insulin-like growth factor binding protein 4 -0.0451567
ZNF638 zinc finger protein 638 -0.0450651
GOLGA4 golgin A4 -0.0449478
AKAP12 A kinase (PRKA) anchor protein 12 -0.0446558
CMIP c-Maf inducing protein -0.0443491
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0442988
VCL vinculin -0.0431732
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 -0.0431061
EML4 echinoderm microtubule associated protein like 4 -0.0420198
NUMB numb homolog (Drosophila) -0.0415686
ZBTB38 zinc finger and BTB domain containing 38 -0.0408091
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0397989
FHIT fragile histidine triad -0.0396646
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0393116
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0390198
MLPH melanophilin -0.0389443
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0389205
FAM107B family with sequence similarity 107, member B -0.0386437
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 -0.0380837
PTGR1 prostaglandin reductase 1 -0.0375203
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) -0.0374489
WWTR1 WW domain containing transcription regulator 1 -0.0372752
NFIA nuclear factor I/A -0.0370945
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0369977
RTN4 reticulon 4 -0.0363975
SETD2 SET domain containing 2 -0.0363926
RBM47 RNA binding motif protein 47 -0.0362635
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0361753
CP ceruloplasmin (ferroxidase) -0.0359549
USP32 ubiquitin specific peptidase 32 -0.0355367
PTK2 protein tyrosine kinase 2 -0.035401
EVA1C eva-1 homolog C (C. elegans) -0.03537
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 -0.035068
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0348794
RDX radixin -0.0348599
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0347978
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0346905
TRIO trio Rho guanine nucleotide exchange factor -0.0345402
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0340338
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 -0.0339841
PM20D1 peptidase M20 domain containing 1 -0.0338959
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0338469
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -0.0337488
WSB1 WD repeat and SOCS box containing 1 -0.0336515
NINL ninein-like -0.0335469
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -0.0332929
KIF13A kinesin family member 13A -0.0326906
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) -0.0323955
RBM6 RNA binding motif protein 6 -0.0321205
EFNA5 ephrin-A5 -0.0319741
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0319227
NCOA7 nuclear receptor coactivator 7 -0.0316796
SEC11A SEC11 homolog A (S. cerevisiae) -0.031536
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0314803
ETFA electron-transfer-flavoprotein, alpha polypeptide -0.031376
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0313659
WWOX WW domain containing oxidoreductase -0.031101
SLC38A2 solute carrier family 38, member 2 -0.0311001
THSD7A thrombospondin, type I, domain containing 7A -0.0310232
PCED1B PC-esterase domain containing 1B -0.0308282
PSEN1 presenilin 1 -0.0307343
POTEF POTE ankyrin domain family, member F -0.0307051
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0303975
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0303888
PTPRK protein tyrosine phosphatase, receptor type, K -0.0303156
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0302046
PDE10A phosphodiesterase 10A -0.0298188
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0296788
USP34 ubiquitin specific peptidase 34 -0.0296751
TNRC6B trinucleotide repeat containing 6B -0.0296574
TCF25 transcription factor 25 (basic helix-loop-helix) -0.0296433
DIAPH2 diaphanous-related formin 2 -0.0293375
MBNL1 muscleblind-like splicing regulator 1 -0.0292946
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0292935
GLIS3 GLIS family zinc finger 3 -0.0292877
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 -0.0290653
AXL AXL receptor tyrosine kinase -0.0290157
MISP mitotic spindle positioning -0.0289892
PCDHB16 protocadherin beta 16 -0.0286389
COP1 COP1 E3 ubiquitin ligase -0.0285005
SSH2 slingshot protein phosphatase 2 -0.0284412
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0284216
NCOA1 nuclear receptor coactivator 1 -0.0282108
COL4A5 collagen, type IV, alpha 5 -0.0280999
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0277018
FAT1 FAT atypical cadherin 1 -0.0275615
NSD2 nuclear receptor binding SET domain protein 2 -0.0275387
MAML3 mastermind-like 3 (Drosophila) -0.0274339
PIKFYVE phosphoinositide kinase, FYVE finger containing -0.0273421
FNDC3B fibronectin type III domain containing 3B -0.0270058
THSD4 thrombospondin, type I, domain containing 4 -0.0268998
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 -0.0268932
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0268681
TXN2 thioredoxin 2 -0.0268464
TM9SF3 transmembrane 9 superfamily member 3 -0.0266471
COBL cordon-bleu WH2 repeat protein -0.0265683
BCL2L1 BCL2-like 1 -0.0263924
PDE8A phosphodiesterase 8A -0.0263799
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0263574
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0262802
RBM5 RNA binding motif protein 5 -0.02626
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -0.0261372
C2CD5 C2 calcium-dependent domain containing 5 -0.0260036
LUC7L LUC7-like (S. cerevisiae) -0.0257336
WAC WW domain containing adaptor with coiled-coil -0.0256465
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0255203
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0254253
UBE2K ubiquitin-conjugating enzyme E2K -0.0253848
PRPF3 pre-mRNA processing factor 3 -0.0251921
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0251515
AKIRIN1 akirin 1 -0.0249075
RPL32 ribosomal protein L32 -0.0248609
MTUS1 microtubule associated tumor suppressor 1 -0.0248577
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0248223
ZFAND6 zinc finger, AN1-type domain 6 -0.0248194
PLCB4 phospholipase C, beta 4 -0.0247834
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0247554
NCOR1 nuclear receptor corepressor 1 -0.0246842
IGSF1 immunoglobulin superfamily, member 1 -0.0246638
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0246393
PRC1 protein regulator of cytokinesis 1 -0.0245848
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0244984
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) -0.0244386
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0242268
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0241287
TAOK3 TAO kinase 3 -0.0241058
TMEM245 transmembrane protein 245 -0.0240945
CYFIP1 cytoplasmic FMR1 interacting protein 1 -0.0240811
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0240281
NECTIN2 nectin cell adhesion molecule 2 -0.0239679
CREBBP CREB binding protein -0.023551
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 -0.0235174
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -0.0235084
SMAD2 SMAD family member 2 -0.0234612
MYO1B myosin IB -0.0234132
PTPRM protein tyrosine phosphatase, receptor type, M -0.0233985
NCOA6 nuclear receptor coactivator 6 -0.0232617
SENP5 SUMO1/sentrin specific peptidase 5 -0.0232597
GRN granulin -0.0231867
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0231578
RPS11 ribosomal protein S11 -0.0231123
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0231066
SHTN1 shootin 1 -0.022953
RPL13A ribosomal protein L13a -0.0227066
IREB2 iron-responsive element binding protein 2 -0.0225606
AKAP13 A kinase (PRKA) anchor protein 13 -0.0224068
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0223612
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0222799
UBR1 ubiquitin protein ligase E3 component n-recognin 1 -0.0222325
RBM23 RNA binding motif protein 23 -0.0221908
GPC6 glypican 6 -0.0221825
FCHSD2 FCH and double SH3 domains 2 -0.0221485
NCOA3 nuclear receptor coactivator 3 -0.0219494
SREBF2 sterol regulatory element binding transcription factor 2 -0.0219038
ACOT9 acyl-CoA thioesterase 9 -0.021899
SP3 Sp3 transcription factor -0.0218769
EFTUD2 elongation factor Tu GTP binding domain containing 2 -0.0218234
ACACB acetyl-CoA carboxylase beta -0.0218123
RPL29 ribosomal protein L29 -0.0218076
RRAS2 related RAS viral (r-ras) oncogene homolog 2 -0.0217555
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 -0.021641
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.021582
PON2 paraoxonase 2 -0.0215798
MYO6 myosin VI -0.0213597
ATAD2B ATPase family, AAA domain containing 2B -0.0213396
TJP1 tight junction protein 1 -0.0213143
FGG fibrinogen gamma chain -0.0213129
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0212374
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0211617
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) -0.0211549
UBTF upstream binding transcription factor, RNA polymerase I -0.0211161
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -0.0211141
IQCB1 IQ motif containing B1 -0.0210912
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like -0.0209545
ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10 -0.0209418
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.020921
ZNF652 zinc finger protein 652 -0.0208674
TNRC18 trinucleotide repeat containing 18 -0.0207432
APP amyloid beta (A4) precursor protein -0.0206742
UBE3C ubiquitin protein ligase E3C -0.0205748
FOXK2 forkhead box K2 -0.0205695
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0205603
PDS5A PDS5 cohesin associated factor A -0.0205223
TECPR2 tectonin beta-propeller repeat containing 2 -0.0204416
PDLIM5 PDZ and LIM domain 5 -0.020435
SLC45A4 solute carrier family 45, member 4 -0.0203952
FOSL1 FOS-like antigen 1 -0.0203923
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0202641
UBAP2 ubiquitin associated protein 2 -0.0202413
WWP1 WW domain containing E3 ubiquitin protein ligase 1 -0.0201529
DNAAF9 dynein axonemal assembly factor 9 -0.0201355
FCGBP Fc fragment of IgG binding protein -0.0201126
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0201119
RNF130 ring finger protein 130 -0.0200918
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 -0.020089
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -0.02007
RPN2 ribophorin II -0.0200177
SCAF11 SR-related CTD-associated factor 11 -0.0199459
RARS1 arginyl-tRNA synthetase 1 -0.0198607
ANO6 anoctamin 6 -0.0198508
GAPVD1 GTPase activating protein and VPS9 domains 1 -0.0198127
RPS19 ribosomal protein S19 -0.0198075
SLC38A1 solute carrier family 38, member 1 -0.0197779
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0197315
ESYT2 extended synaptotagmin-like protein 2 -0.0197245
NAMPT nicotinamide phosphoribosyltransferase -0.019683
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase -0.019618
AFF1 AF4/FMR2 family, member 1 -0.0195526
SRRM1 serine/arginine repetitive matrix 1 -0.0194922
MAPK8 mitogen-activated protein kinase 8 -0.019409
CDC123 cell division cycle 123 -0.0193562
PKM pyruvate kinase, muscle -0.0193446
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 -0.0193188
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.019312
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.0192634
DAPK1 death-associated protein kinase 1 -0.019173
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit -0.019154
OSGIN2 oxidative stress induced growth inhibitor family member 2 -0.0191379
ARID1B AT rich interactive domain 1B (SWI1-like) -0.019135
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa -0.019119
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.019115
CFDP1 craniofacial development protein 1 -0.019082
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0190323
MACROD2 MACRO domain containing 2 -0.0190216
MBTPS1 membrane-bound transcription factor peptidase, site 1 -0.0190031
CD63 CD63 molecule -0.0190014
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 -0.0189876
LONP1 lon peptidase 1, mitochondrial -0.0189562
EPC1 enhancer of polycomb homolog 1 (Drosophila) -0.0189419
RBMX RNA binding motif protein, X-linked -0.0189173
SPATA7 spermatogenesis associated 7 -0.0188435
KMT5B lysine methyltransferase 5B -0.0188195
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) -0.0188168
PER2 period circadian clock 2 -0.0187935
TENT2 terminal nucleotidyltransferase 2 -0.0187759
PHACTR4 phosphatase and actin regulator 4 -0.0187332
ATRAID all-trans retinoic acid-induced differentiation factor -0.0187121
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0187075
ATXN10 ataxin 10 -0.0186936
CCDC146 coiled-coil domain containing 146 -0.0186855
ARF4 ADP-ribosylation factor 4 -0.0186844
PARD3B par-3 family cell polarity regulator beta -0.0186777
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) -0.0186375
IL13RA1 interleukin 13 receptor, alpha 1 -0.0186277
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 -0.0185098
LMO7 LIM domain 7 -0.0184974
CNTNAP3 contactin associated protein-like 3 -0.0184686
SPPL2A signal peptide peptidase like 2A -0.0184664
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0184538
RETREG3 reticulophagy regulator family member 3 -0.0184411
EPN2 epsin 2 -0.0184404
BLVRB biliverdin reductase B -0.0184135
IMMT inner membrane protein, mitochondrial -0.0184038
NFX1 nuclear transcription factor, X-box binding 1 -0.0183898
PEX14 peroxisomal biogenesis factor 14 -0.0183437
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0183223
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0183021
ETV6 ets variant 6 -0.0182998
RORA RAR-related orphan receptor A -0.0182959
CEBPZOS CEBPZ opposite strand -0.0182882
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0182473
TMC5 transmembrane channel-like 5 -0.0182176
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0182016
PTEN phosphatase and tensin homolog -0.0181959
SKIL SKI-like proto-oncogene -0.0181802
FOXJ3 forkhead box J3 -0.0181227
CLASRP CLK4-associating serine/arginine rich protein -0.0180612
MFF mitochondrial fission factor -0.0180489
PPP6R2 protein phosphatase 6, regulatory subunit 2 -0.0180235
FAM177A1 family with sequence similarity 177, member A1 -0.0180046
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0179997
TUBB6 tubulin, beta 6 class V -0.0178899
FNDC3A fibronectin type III domain containing 3A -0.017822
FMNL2 formin-like 2 -0.0177727
NEMF nuclear export mediator factor -0.0177406
PTPRA protein tyrosine phosphatase, receptor type, A -0.0177138
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.017713
RPSA ribosomal protein SA -0.0176927
TMEM184A transmembrane protein 184A -0.0176245
CHD8 chromodomain helicase DNA binding protein 8 -0.0176129
STXBP3 syntaxin binding protein 3 -0.0176068
ANXA7 annexin A7 -0.0175828
PLEKHA7 pleckstrin homology domain containing, family A member 7 -0.0175497
TPT1 tumor protein, translationally-controlled 1 -0.0175287
ZNF704 zinc finger protein 704 -0.017526
SSH1 slingshot protein phosphatase 1 -0.0175234
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 -0.0175065
CNKSR3 CNKSR family member 3 -0.0173658
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.017324
BORCS5 BLOC-1 related complex subunit 5 -0.0173209
SQSTM1 sequestosome 1 -0.0172138
BICC1 BicC family RNA binding protein 1 -0.0172036
KIFC3 kinesin family member C3 -0.0171627
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0171547
RASEF RAS and EF-hand domain containing -0.0171245
TTF1 transcription termination factor, RNA polymerase I -0.0170799
IPO9 importin 9 -0.0170651
CAV1 caveolin 1, caveolae protein, 22kDa -0.0170605
SCYL1 SCY1-like 1 (S. cerevisiae) -0.0169233
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0169221
STIM1 stromal interaction molecule 1 -0.0168935
KLHL24 kelch-like family member 24 -0.0168015
MED13 mediator complex subunit 13 -0.0167987
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 -0.0167433
TCP11L1 t-complex 11, testis-specific-like 1 -0.0167182
SYAP1 synapse associated protein 1 -0.0167083
CADM2 cell adhesion molecule 2 -0.0166963
USP9X ubiquitin specific peptidase 9, X-linked -0.0166919
FRMD3 FERM domain containing 3 -0.0166904
DSCAML1 Down syndrome cell adhesion molecule like 1 -0.0166778
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) -0.0166608
OSTM1 osteopetrosis associated transmembrane protein 1 -0.0166608
BMPR1A bone morphogenetic protein receptor, type IA -0.0166541
AGFG1 ArfGAP with FG repeats 1 -0.0165815
TRAM1 translocation associated membrane protein 1 -0.0165486
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0165456
CHSY1 chondroitin sulfate synthase 1 -0.0165173
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0164648
NRP1 neuropilin 1 -0.0164525
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 -0.0164024
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0163982
STIL SCL/TAL1 interrupting locus -0.0163884
DUSP5 dual specificity phosphatase 5 -0.0163743
GAK cyclin G associated kinase -0.0163559
TTC7A tetratricopeptide repeat domain 7A -0.0163307
EYA4 EYA transcriptional coactivator and phosphatase 4 -0.0163213
ATXN1 ataxin 1 -0.0162798
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -0.0162767
MARCHF5 membrane associated ring-CH-type finger 5 -0.0162284
MAGT1 magnesium transporter 1 -0.0162253
RPS25 ribosomal protein S25 -0.0162246
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0161929
SPACA6 sperm acrosome associated 6 -0.016178
PHYKPL 5-phosphohydroxy-L-lysine phospho-lyase -0.0161168
MDFIC MyoD family inhibitor domain containing -0.016113
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0160692
AHCYL2 adenosylhomocysteinase-like 2 -0.016048
TP53 tumor protein p53 -0.0160416
ITFG2 integrin alpha FG-GAP repeat containing 2 -0.0159824
COL5A2 collagen, type V, alpha 2 -0.01596
URI1 URI1, prefoldin-like chaperone -0.015944
DENND4A DENN/MADD domain containing 4A -0.0159318
FGL1 fibrinogen-like 1 -0.0158514
BIRC6 baculoviral IAP repeat containing 6 -0.0158256
CCNI cyclin I -0.0158246
MAP2K4 mitogen-activated protein kinase kinase 4 -0.015801
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) -0.0158001
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae) -0.0157879
DPYSL2 dihydropyrimidinase-like 2 -0.0157599
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0157598
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0157472
TUBGCP5 tubulin, gamma complex associated protein 5 -0.015734
NBEA neurobeachin -0.0157273
GCC2 GRIP and coiled-coil domain containing 2 -0.0157019
RFX3 regulatory factor X, 3 (influences HLA class II expression) -0.0156909
MAP3K8 mitogen-activated protein kinase kinase kinase 8 -0.0156534
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4 -0.0156446
C2ORF42 chromosome 2 open reading frame 42 -0.0156006
LTBP4 latent transforming growth factor beta binding protein 4 -0.0156006
RAB11FIP3 RAB11 family interacting protein 3 (class II) -0.0155967
HNRNPM heterogeneous nuclear ribonucleoprotein M -0.015595
KLHL5 kelch-like family member 5 -0.015593
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast) -0.0155847
RNF115 ring finger protein 115 -0.0155659
SEPTIN9 septin 9 -0.0155577
HELZ helicase with zinc finger -0.0155472
TMEM156 transmembrane protein 156 -0.0155202
PTPRG protein tyrosine phosphatase, receptor type, G -0.0154614
PDGFD platelet derived growth factor D -0.0154614
EML2 echinoderm microtubule associated protein like 2 -0.0154613
TMEM117 transmembrane protein 117 -0.0154474
RIOK3 RIO kinase 3 -0.0154148
CHMP1A charged multivesicular body protein 1A -0.0154091
NUP210 nucleoporin 210kDa -0.0154088
ALPK2 alpha-kinase 2 -0.0154031
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0153948
ASCC1 activating signal cointegrator 1 complex subunit 1 -0.015387
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing -0.0153557
TUBD1 tubulin, delta 1 -0.0153518
PCLO piccolo presynaptic cytomatrix protein -0.0153457
CST1 cystatin SN -0.0153172
MYO18A myosin XVIIIA -0.0153092
TBL1X transducin (beta)-like 1X-linked -0.0152787
DOCK4 dedicator of cytokinesis 4 -0.0152701
DENND6A DENN/MADD domain containing 6A -0.0152534
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -0.0152299
RILPL1 Rab interacting lysosomal protein-like 1 -0.0152226
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.015203
WDR41 WD repeat domain 41 -0.0151919
PLPP1 phospholipid phosphatase 1 -0.0151824
TLK2 tousled-like kinase 2 -0.0151727
PHF20 PHD finger protein 20 -0.0151559
CEMIP2 cell migration inducing hyaluronidase 2 -0.0151049
PPP1R13B protein phosphatase 1, regulatory subunit 13B -0.0150668
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0150664
BMERB1 bMERB domain containing 1 -0.015014
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa -0.0150011
FGA fibrinogen alpha chain -0.014982
DCDC1 doublecortin domain containing 1 -0.0149816
ZBTB4 zinc finger and BTB domain containing 4 -0.0149663
EPB41L4A erythrocyte membrane protein band 4.1 like 4A -0.0149565
RHOQ ras homolog family member Q -0.0149558
NAP1L1 nucleosome assembly protein 1-like 1 -0.0149532
SRC SRC proto-oncogene, non-receptor tyrosine kinase -0.0149379
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 -0.0149362
POLR1A polymerase (RNA) I polypeptide A, 194kDa -0.0149334
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0149322
CABLES1 Cdk5 and Abl enzyme substrate 1 -0.0149286
YPEL2 yippee-like 2 (Drosophila) -0.0149228
N4BP2 NEDD4 binding protein 2 -0.0149218
SLC35E1 solute carrier family 35, member E1 -0.0149157
KIF11 kinesin family member 11 -0.0148967
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0148946
VEZT vezatin, adherens junctions transmembrane protein -0.0148945
WDR59 WD repeat domain 59 -0.0148923
FKBP10 FK506 binding protein 10, 65 kDa -0.0148805
BAX BCL2-associated X protein -0.0148583
UBXN4 UBX domain protein 4 -0.0148485
MRPS35 mitochondrial ribosomal protein S35 -0.0148315
AKAP11 A kinase (PRKA) anchor protein 11 -0.0148276
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type -0.0147862
CEP41 centrosomal protein 41kDa -0.0147784
FAF2 Fas associated factor family member 2 -0.0147685
SLC49A4 solute carrier family 49 member 4 -0.0147366
CATSPERB catsper channel auxiliary subunit beta -0.0147133
DCLK2 doublecortin-like kinase 2 -0.014705
NR2C1 nuclear receptor subfamily 2, group C, member 1 -0.0147028
RPTOR regulatory associated protein of MTOR, complex 1 -0.0146884
SEPTIN6 septin 6 -0.0146581
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0146459
PCSK6 proprotein convertase subtilisin/kexin type 6 -0.0146074
UNC93B1 unc-93 homolog B1 (C. elegans) -0.0146048
CLIP2 CAP-GLY domain containing linker protein 2 -0.0146048
PKN1 protein kinase N1 -0.0145788
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0145709
CTNNBL1 catenin, beta like 1 -0.0145607
BABAM2 BRISC and BRCA1 A complex member 2 -0.0145595
SEC63 SEC63 homolog (S. cerevisiae) -0.0145453
YY1AP1 YY1 associated protein 1 -0.0145427
RLF rearranged L-myc fusion -0.0145137
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.0144987
AUH AU RNA binding protein/enoyl-CoA hydratase -0.0144399
ATP9A ATPase, class II, type 9A -0.0144258
FBXL20 F-box and leucine-rich repeat protein 20 -0.0144207
GOLPH3L golgi phosphoprotein 3-like -0.0144195
BHLHE40 basic helix-loop-helix family, member e40 -0.0144163
GRB10 growth factor receptor-bound protein 10 -0.0143783
ZNF518A zinc finger protein 518A -0.0143757
SCO1 SCO1 cytochrome c oxidase assembly protein -0.014367
CAPNS1 calpain, small subunit 1 -0.0143648
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B -0.0143615
UNC13A unc-13 homolog A (C. elegans) -0.0143121
KIF1B kinesin family member 1B -0.0142527
MEGF9 multiple EGF-like-domains 9 -0.0142168
RAB35 RAB35, member RAS oncogene family -0.0142114
TBC1D12 TBC1 domain family, member 12 -0.0142079
INO80D INO80 complex subunit D -0.0142
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase -0.0141718
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.014165
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.014137
MEF2D myocyte enhancer factor 2D -0.014135
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0141218
IFT140 intraflagellar transport 140 -0.0140864
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0140641
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha -0.0140494
MAN2C1 mannosidase, alpha, class 2C, member 1 -0.0140448
FBXL2 F-box and leucine-rich repeat protein 2 -0.0140289
ALG8 ALG8, alpha-1,3-glucosyltransferase -0.0140229
SPRED1 sprouty-related, EVH1 domain containing 1 -0.0140211
SEZ6L2 seizure related 6 homolog (mouse)-like 2 -0.0140149
ST7L suppression of tumorigenicity 7 like -0.0139894
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0139737
DNMBP dynamin binding protein -0.0139602
ZFYVE9 zinc finger, FYVE domain containing 9 -0.0139402