A549_GSK J1_10µM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description GSK J1 10µM perturbation in A549 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the A549_GSK J1_10µM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.171245
KRT8 keratin 8, type II 0.157997
PKM pyruvate kinase, muscle 0.124951
FTL ferritin, light polypeptide 0.115083
ACTN4 actinin, alpha 4 0.0954042
RPLP1 ribosomal protein, large, P1 0.0882713
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0800713
ANXA2 annexin A2 0.0728187
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.068113
RPLP0 ribosomal protein, large, P0 0.0654514
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0653332
CLU clusterin 0.06526
ENO1 enolase 1, (alpha) 0.0614267
KRT18 keratin 18, type I 0.0610843
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0605493
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.059708
FTH1 ferritin, heavy polypeptide 1 0.0526331
RPS3 ribosomal protein S3 0.0517086
SETX senataxin 0.0512948
BSG basigin (Ok blood group) 0.0503569
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0478343
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0458494
GPX2 glutathione peroxidase 2 0.0458454
GLG1 golgi glycoprotein 1 0.0448753
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0440783
MUSK muscle, skeletal, receptor tyrosine kinase 0.0436602
ZNF609 zinc finger protein 609 0.0436495
EFNA5 ephrin-A5 0.0430887
PFN1 profilin 1 0.043033
CD151 CD151 molecule (Raph blood group) 0.0411284
ACACA acetyl-CoA carboxylase alpha 0.0402807
EXT1 exostosin glycosyltransferase 1 0.0391132
FLNB filamin B, beta 0.0389607
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0377714
PHGDH phosphoglycerate dehydrogenase 0.0374412
TXN2 thioredoxin 2 0.036834
RPS18 ribosomal protein S18 0.0366506
TM4SF1 transmembrane 4 L six family member 1 0.0363137
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.036021
KRT81 keratin 81, type II 0.0356404
AKR1C2 aldo-keto reductase family 1, member C2 0.0355616
EXOC6B exocyst complex component 6B 0.0354633
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0352443
SDC1 syndecan 1 0.0349836
TKT transketolase 0.0346742
DENND5B DENN/MADD domain containing 5B 0.0344301
PLPP1 phospholipid phosphatase 1 0.0343401
FAF1 Fas (TNFRSF6) associated factor 1 0.0341294
CAVIN1 caveolae associated protein 1 0.0338859
ENSA endosulfine alpha 0.0338735
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.033617
BMP6 bone morphogenetic protein 6 0.0334705
ASPH aspartate beta-hydroxylase 0.0331464
CMIP c-Maf inducing protein 0.0329407
S100A6 S100 calcium binding protein A6 0.0327474
GSTP1 glutathione S-transferase pi 1 0.0327416
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0324377
RPL29 ribosomal protein L29 0.0323846
UBL4A ubiquitin-like 4A 0.0321658
UBTF upstream binding transcription factor, RNA polymerase I 0.0320978
UGDH UDP-glucose 6-dehydrogenase 0.0318486
SNX6 sorting nexin 6 0.0317822
BRCA1 breast cancer 1, early onset 0.0317629
IL6ST interleukin 6 signal transducer 0.0316561
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0316157
SKIC3 SKI3 subunit of superkiller complex 0.0315904
RPL30 ribosomal protein L30 0.031282
RFX7 regulatory factor X, 7 0.0312313
SMIM44 small integral membrane protein 44 0.031201
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.0311609
KIF5B kinesin family member 5B 0.0309532
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.030252
MPRIP myosin phosphatase Rho interacting protein 0.0301619
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.0301364
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.0300757
DSG2 desmoglein 2 0.029875
VDAC2 voltage-dependent anion channel 2 0.0297974
ZNF148 zinc finger protein 148 0.0297111
RBBP7 retinoblastoma binding protein 7 0.0296607
TMPO thymopoietin 0.0295169
FADS2 fatty acid desaturase 2 0.0294013
GSK3B glycogen synthase kinase 3 beta 0.0293702
CALR calreticulin 0.0287134
RHBDD3 rhomboid domain containing 3 0.0286938
KPNB1 karyopherin (importin) beta 1 0.028631
SMYD3 SET and MYND domain containing 3 0.028602
SREBF2 sterol regulatory element binding transcription factor 2 0.0284373
CKAP4 cytoskeleton-associated protein 4 0.0282037
RPL37A ribosomal protein L37a 0.0281103
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0279021
ATP5MC2 ATP synthase membrane subunit c locus 2 0.0271424
PON2 paraoxonase 2 0.0268087
MTPN myotrophin 0.0267289
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0266467
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0263408
MTUS1 microtubule associated tumor suppressor 1 0.0263115
DHCR7 7-dehydrocholesterol reductase 0.0261473
RPL23 ribosomal protein L23 0.0259596
TGOLN2 trans-golgi network protein 2 0.0254496
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 0.0254416
VKORC1L1 vitamin K epoxide reductase complex, subunit 1-like 1 0.02535
MAGT1 magnesium transporter 1 0.0249444
TBC1D5 TBC1 domain family, member 5 0.024941
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 0.0247639
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0245956
VRK2 vaccinia related kinase 2 0.0245444
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 0.024458
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 0.0243603
RPS2 ribosomal protein S2 0.0243243
UBE2O ubiquitin-conjugating enzyme E2O 0.0241951
RACK1 receptor for activated C kinase 1 0.0241771
IQGAP1 IQ motif containing GTPase activating protein 1 0.0240844
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0240688
SETD2 SET domain containing 2 0.0239871
ANKFY1 ankyrin repeat and FYVE domain containing 1 0.0239814
RPL31 ribosomal protein L31 0.023954
PLD5 phospholipase D family, member 5 0.0236216
MITF microphthalmia-associated transcription factor 0.0236203
EMC10 ER membrane protein complex subunit 10 0.0235913
GLS2 glutaminase 2 (liver, mitochondrial) 0.0234921
MKI67 marker of proliferation Ki-67 0.0234092
FNBP1L formin binding protein 1-like 0.0234039
UBN2 ubinuclein 2 0.0233877
CEMIP cell migration inducing protein, hyaluronan binding 0.0233763
MYO1E myosin IE 0.0232861
AGR2 anterior gradient 2 0.0232468
YLPM1 YLP motif containing 1 0.0232141
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 0.0230225
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0229531
GPC1 glypican 1 0.0229198
ATF6 activating transcription factor 6 0.0227976
PRC1 protein regulator of cytokinesis 1 0.0227896
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0227829
HACD2 3-hydroxyacyl-CoA dehydratase 2 0.0227215
PDE10A phosphodiesterase 10A 0.0227045
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0226883
CCT7 chaperonin containing TCP1, subunit 7 (eta) 0.0226756
RPL13A ribosomal protein L13a 0.0226726
CALU calumenin 0.0226601
RPS6 ribosomal protein S6 0.0226435
ARB2A ARB2 cotranscriptional regulator A 0.0225175
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0224781
EPB41L4A erythrocyte membrane protein band 4.1 like 4A 0.0224655
AKAP10 A kinase (PRKA) anchor protein 10 0.0224383
DHX37 DEAH (Asp-Glu-Ala-His) box polypeptide 37 0.022373
PDE7B phosphodiesterase 7B 0.0222504
EIF3B eukaryotic translation initiation factor 3, subunit B 0.0221701
PAPOLA poly(A) polymerase alpha 0.0220888
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 0.0220541
CST3 cystatin C 0.0220003
NRIP1 nuclear receptor interacting protein 1 0.0219994
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 0.0219986
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 0.0219911
CLSTN1 calsyntenin 1 0.0219623
VIM vimentin 0.0218341
CCDC57 coiled-coil domain containing 57 0.0216074
SPNS1 spinster homolog 1 (Drosophila) 0.0215714
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 0.0214759
EZR ezrin 0.021316
C2CD3 C2 calcium-dependent domain containing 3 0.0212703
CKAP5 cytoskeleton associated protein 5 0.0212149
SON SON DNA binding protein 0.0211828
TOP1 topoisomerase (DNA) I 0.0211635
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.0211276
SERBP1 SERPINE1 mRNA binding protein 1 0.02103
TOB1 transducer of ERBB2, 1 0.0210217
UBA2 ubiquitin-like modifier activating enzyme 2 0.0210093
SETD3 SET domain containing 3 0.0208761
NCAPD2 non-SMC condensin I complex, subunit D2 0.0208267
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0207786
TESC tescalcin 0.0207158
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0206836
UCK2 uridine-cytidine kinase 2 0.0205752
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0204833
XPO1 exportin 1 0.0204505
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0204445
LDAH lipid droplet associated hydrolase 0.0203052
NAGLU N-acetylglucosaminidase, alpha 0.0202773
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 0.0201886
TK1 thymidine kinase 1, soluble 0.0201768
CEP350 centrosomal protein 350kDa 0.0201641
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.0200872
TMEM135 transmembrane protein 135 0.0199116
CLSPN claspin 0.0198829
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 0.019842
RPL3 ribosomal protein L3 0.019829
HACD3 3-hydroxyacyl-CoA dehydratase 3 0.0198074
CATSPERB catsper channel auxiliary subunit beta 0.019799
RPL9 ribosomal protein L9 0.0197735
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.019748
ADAM10 ADAM metallopeptidase domain 10 0.0197398
RSPO3 R-spondin 3 0.0197196
RPS23 ribosomal protein S23 0.0197084
SNRPA small nuclear ribonucleoprotein polypeptide A 0.0196695
APMAP adipocyte plasma membrane associated protein 0.0196351
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.019629
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.0196284
TMEM97 transmembrane protein 97 0.0196191
AP2S1 adaptor-related protein complex 2, sigma 1 subunit 0.0196073
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) 0.0195822
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0195501
SLC39A11 solute carrier family 39, member 11 0.0195396
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.0194566
ABHD12 abhydrolase domain containing 12 0.0193705
GIGYF2 GRB10 interacting GYF protein 2 0.0192491
SLC39A10 solute carrier family 39 (zinc transporter), member 10 0.0192175
S100A4 S100 calcium binding protein A4 0.0192087
CCT4 chaperonin containing TCP1, subunit 4 (delta) 0.0191451
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.0191204
ALMS1 Alstrom syndrome protein 1 0.0190917
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 0.0190844
REEP3 receptor accessory protein 3 0.0189537
ODF2 outer dense fiber of sperm tails 2 0.0189172
SFT2D2 SFT2 domain containing 2 0.0189089
XPO4 exportin 4 0.0189049
GCLM glutamate-cysteine ligase, modifier subunit 0.0188899
RDX radixin 0.0188825
HTATSF1 HIV-1 Tat specific factor 1 0.0188404
POTEF POTE ankyrin domain family, member F 0.0188355
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0188313
KIF20B kinesin family member 20B 0.0188105
KIF18B kinesin family member 18B 0.0187586
CTSL cathepsin L 0.0187237
RTTN rotatin 0.0187114
EPN2 epsin 2 0.0186954
HDAC8 histone deacetylase 8 0.0186935
PTPRA protein tyrosine phosphatase, receptor type, A 0.0185925
CASC3 cancer susceptibility candidate 3 0.0185795
SQLE squalene epoxidase 0.0185211
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0184976
GOLM1 golgi membrane protein 1 0.0184953
MYADM myeloid-associated differentiation marker 0.018494
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0184892
SET SET nuclear proto-oncogene 0.0184337
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0184155
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 0.0183962
TM7SF3 transmembrane 7 superfamily member 3 0.0183865
EIF3J eukaryotic translation initiation factor 3, subunit J 0.0183818
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit 0.0183569
FASN fatty acid synthase 0.0183265
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 0.0183085
KIF4A kinesin family member 4A 0.0182695
RBM28 RNA binding motif protein 28 0.0182695
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0181964
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0181717
CLPTM1L CLPTM1-like 0.0181521
PHB2 prohibitin 2 0.018069
FBXO17 F-box protein 17 0.0180143
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.0179612
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0179146
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 0.0178706
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.0178456
HELB helicase (DNA) B 0.0178293
RPS4X ribosomal protein S4, X-linked 0.0178143
MED14 mediator complex subunit 14 0.0176004
KIF11 kinesin family member 11 0.0175974
SCAPER S-phase cyclin A-associated protein in the ER 0.0175952
ATP5F1D ATP synthase F1 subunit delta 0.0175904
RPL32 ribosomal protein L32 0.0175846
PIGK phosphatidylinositol glycan anchor biosynthesis, class K 0.0175561
EREG epiregulin 0.0175547
MSH2 mutS homolog 2 0.0175288
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G 0.0174801
GOLPH3L golgi phosphoprotein 3-like 0.0174524
TPST1 tyrosylprotein sulfotransferase 1 0.0174518
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 0.0174293
CD81 CD81 molecule 0.0173922
UVRAG UV radiation resistance associated 0.0173665
WDFY2 WD repeat and FYVE domain containing 2 0.0173391
LLPH LLP homolog, long-term synaptic facilitation (Aplysia) 0.0172983
PGRMC2 progesterone receptor membrane component 2 0.0172795
CLTC clathrin, heavy chain (Hc) 0.0172615
TOM1L2 target of myb1-like 2 (chicken) 0.0172275
SLC19A1 solute carrier family 19 (folate transporter), member 1 0.0171735
EPC1 enhancer of polycomb homolog 1 (Drosophila) 0.0171464
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein 0.0171301
CCND3 cyclin D3 0.0171165
PRRC2B proline-rich coiled-coil 2B 0.0171094
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 0.0171084
FBXW11 F-box and WD repeat domain containing 11 0.0170606
ATE1 arginyltransferase 1 0.017055
HLA-E major histocompatibility complex, class I, E 0.0170186
CENPP centromere protein P 0.0169549
CUL3 cullin 3 0.016915
CEP128 centrosomal protein 128kDa 0.0168948
TRIM16 tripartite motif containing 16 0.0168361
SOGA1 suppressor of glucose, autophagy associated 1 0.0167475
BCAP31 B-cell receptor-associated protein 31 0.0166994
COMMD1 copper metabolism (Murr1) domain containing 1 0.0166345
SCCPDH saccharopine dehydrogenase (putative) 0.0165881
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae) 0.0165346
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.0165198
CAPN2 calpain 2, (m/II) large subunit 0.0164715
TCTN3 tectonic family member 3 0.0164336
PRDX4 peroxiredoxin 4 0.0163411
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 0.0163373
PURB purine-rich element binding protein B 0.016331
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.0163251
AFTPH aftiphilin 0.0162924
NPAS2 neuronal PAS domain protein 2 0.0162678
LRIF1 ligand dependent nuclear receptor interacting factor 1 0.0162602
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 0.0162448
EIF3D eukaryotic translation initiation factor 3, subunit D 0.0162153
NMT1 N-myristoyltransferase 1 0.0162144
ZCCHC14 zinc finger, CCHC domain containing 14 0.0162004
NONO non-POU domain containing, octamer-binding 0.0161579
CENPE centromere protein E, 312kDa 0.0160899
EMP3 epithelial membrane protein 3 0.01608
SFMBT1 Scm-like with four mbt domains 1 0.01607
RPL36 ribosomal protein L36 0.0160594
PDIA3 protein disulfide isomerase family A, member 3 0.0160572
CENPF centromere protein F, 350/400kDa 0.0160403
N4BP1 NEDD4 binding protein 1 0.0160213
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0160064
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.0159872
PBX3 pre-B-cell leukemia homeobox 3 0.0159837
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 0.0159504
ATXN7 ataxin 7 0.0159034
H1-10 H1.10 linker histone 0.0158933
SH3PXD2A SH3 and PX domains 2A 0.0158876
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic) 0.0158684
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.0158623
SPINT2 serine peptidase inhibitor, Kunitz type, 2 0.0158368
TFG TRK-fused gene 0.0158264
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0158081
UBN1 ubinuclein 1 0.0158044
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 0.0157719
ATRAID all-trans retinoic acid-induced differentiation factor 0.0157168
H2AZ2 H2A.Z variant histone 2 0.0157158
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0157046
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0157
PLEKHA7 pleckstrin homology domain containing, family A member 7 0.0157
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma 0.0156952
MON2 MON2 homolog (S. cerevisiae) 0.0156752
TANGO6 transport and golgi organization 6 homolog (Drosophila) 0.0156691
CBX3 chromobox homolog 3 0.0156229
SOS2 son of sevenless homolog 2 (Drosophila) 0.0156105
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 0.0155668
PPA2 pyrophosphatase (inorganic) 2 0.0155127
IGSF1 immunoglobulin superfamily, member 1 0.0154638
PEPD peptidase D 0.0154292
MACF1 microtubule-actin crosslinking factor 1 0.0154254
RPL19 ribosomal protein L19 0.015423
CEP89 centrosomal protein 89kDa 0.0154189
PBX1 pre-B-cell leukemia homeobox 1 0.0154186
KRT19 keratin 19, type I 0.0154172
SMAD2 SMAD family member 2 0.0153833
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) 0.0153758
EFTUD2 elongation factor Tu GTP binding domain containing 2 0.0153678
SGMS1 sphingomyelin synthase 1 0.015351
IMMT inner membrane protein, mitochondrial 0.0153329
CYB5B cytochrome b5 type B (outer mitochondrial membrane) 0.0153255
HMMR hyaluronan-mediated motility receptor (RHAMM) 0.0152994
LDLR low density lipoprotein receptor 0.0152774
ZNF668 zinc finger protein 668 0.0152737
SDCCAG8 serologically defined colon cancer antigen 8 0.0152672
MFGE8 milk fat globule-EGF factor 8 protein 0.0152505
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.0152243
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 0.0152095
JAK1 Janus kinase 1 0.0152043
RANBP2 RAN binding protein 2 0.0151951
RRBP1 ribosome binding protein 1 0.0151942
MYEF2 myelin expression factor 2 0.0151757
FXYD6-FXYD2 FXYD6-FXYD2 readthrough 0.0151548
CANX calnexin 0.0151488
MRPL30 mitochondrial ribosomal protein L30 0.0151484
SSRP1 structure specific recognition protein 1 0.0150952
NCKAP1 NCK-associated protein 1 0.0150946
EMC7 ER membrane protein complex subunit 7 0.0150928
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 0.0150738
ERLIN1 ER lipid raft associated 1 0.0150445
GRB14 growth factor receptor-bound protein 14 0.0150287
DDTL D-dopachrome tautomerase-like 0.0149903
TSEN2 TSEN2 tRNA splicing endonuclease subunit 0.0149705
AHR aryl hydrocarbon receptor 0.0149576
C2CD2 C2 calcium-dependent domain containing 2 0.0149223
CPLX2 complexin 2 0.0149068
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0149047
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) 0.0149002
ANXA1 annexin A1 0.0148884
GRB2 growth factor receptor-bound protein 2 0.0148752
VASP vasodilator-stimulated phosphoprotein 0.0148526
MOSMO modulator of smoothened 0.0148513
SYMPK symplekin 0.0148246
NGLY1 N-glycanase 1 0.0148237
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0147881
REEP5 receptor accessory protein 5 0.0147535
TUBB tubulin, beta class I 0.0147247
ZCCHC7 zinc finger, CCHC domain containing 7 0.0146983
LDLRAD3 low density lipoprotein receptor class A domain containing 3 0.0146262
MYO1B myosin IB 0.0146224
SORT1 sortilin 1 0.0145756
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0145275
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0145241
AFG3L2 AFG3-like AAA ATPase 2 0.0145149
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.0145131
CCDC12 coiled-coil domain containing 12 0.0145124
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.0144967
TET2 tet methylcytosine dioxygenase 2 0.014494
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1 0.0144713
PDE4B phosphodiesterase 4B, cAMP-specific 0.0144523
ADCY9 adenylate cyclase 9 0.0144399
SPINDOC spindlin interactor and repressor of chromatin binding 0.0144166
TMTC3 transmembrane and tetratricopeptide repeat containing 3 0.0144101
FKBP1A FK506 binding protein 1A, 12kDa 0.0143956
NECTIN2 nectin cell adhesion molecule 2 0.0143763
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.0143587
LAMB1 laminin, beta 1 0.0143444
FAM174C family with sequence similarity 174 member C 0.014328
FMN1 formin 1 0.0143224
RABGAP1L RAB GTPase activating protein 1-like 0.0143215
CHSY1 chondroitin sulfate synthase 1 0.0143011
KDM2A lysine (K)-specific demethylase 2A 0.0142858
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 0.0142712
CADM1 cell adhesion molecule 1 0.0142683
ECD ecdysoneless homolog (Drosophila) 0.0142417
TCERG1 transcription elongation regulator 1 0.014209
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0141946
MRPS27 mitochondrial ribosomal protein S27 0.0141762
USP39 ubiquitin specific peptidase 39 0.0141607
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0141283
FXYD2 FXYD domain containing ion transport regulator 2 0.0141251
NOL10 nucleolar protein 10 0.0140877
TNS4 tensin 4 0.0140717
KIAA1958 KIAA1958 0.0140622
SHMT1 serine hydroxymethyltransferase 1 (soluble) 0.0140523
ILF3 interleukin enhancer binding factor 3, 90kDa 0.0140492
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.0140262
VARS1 valyl-tRNA synthetase 1 0.0140134
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 0.0140132
UNC93B1 unc-93 homolog B1 (C. elegans) 0.0140053
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.0139996
ZNF337 zinc finger protein 337 0.0139791
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0139677
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 0.013967
BLVRB biliverdin reductase B 0.0139556
TPI1 triosephosphate isomerase 1 0.0138945
TGM2 transglutaminase 2 0.0138913
S100A10 S100 calcium binding protein A10 0.0138841
KMT2D lysine (K)-specific methyltransferase 2D 0.0138552
INSIG1 insulin induced gene 1 0.0138356
DHDDS dehydrodolichyl diphosphate synthase 0.0138354
WDR76 WD repeat domain 76 0.013834
ENOX2 ecto-NOX disulfide-thiol exchanger 2 0.0138321
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0138122
RTN4 reticulon 4 0.0138119
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0138118
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial 0.0138059
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 0.013775
MAVS mitochondrial antiviral signaling protein 0.0137433
SSBP3 single stranded DNA binding protein 3 0.0137416
SIVA1 SIVA1, apoptosis-inducing factor 0.0137309
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) 0.0137209
AP1G2 adaptor-related protein complex 1, gamma 2 subunit 0.0137106
ARL4C ADP-ribosylation factor-like 4C 0.0136681
DPYSL2 dihydropyrimidinase-like 2 0.0136671
SEC63 SEC63 homolog (S. cerevisiae) 0.0136298
IGFBP3 insulin-like growth factor binding protein 3 0.0136145
PCGF6 polycomb group ring finger 6 0.0136079
RHOA ras homolog family member A 0.0135985
TRIM26 tripartite motif containing 26 0.0135825
RHBDD2 rhomboid domain containing 2 0.013577
RCCD1 RCC1 domain containing 1 0.0135648
CASP2 caspase 2, apoptosis-related cysteine peptidase 0.0135519
CEP78 centrosomal protein 78kDa 0.0135394
VPS25 vacuolar protein sorting 25 homolog (S. cerevisiae) 0.0135276
LAMP1 lysosomal-associated membrane protein 1 0.0135044
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 0.013464
RNF145 ring finger protein 145 0.013433
FANCA Fanconi anemia, complementation group A 0.0134291
ALG8 ALG8, alpha-1,3-glucosyltransferase 0.0134078
PLXNB2 plexin B2 0.0134013
REV1 REV1, polymerase (DNA directed) 0.0133979
SELENOO selenoprotein O 0.0133861
MAU2 MAU2 sister chromatid cohesion factor 0.013372
PPP1R21 protein phosphatase 1, regulatory subunit 21 0.0133611
INTS10 integrator complex subunit 10 0.0133608
OSBP oxysterol binding protein 0.0133508
CYP2S1 cytochrome P450, family 2, subfamily S, polypeptide 1 0.0133469
FZD2 frizzled class receptor 2 0.0133349
HPRT1 hypoxanthine phosphoribosyltransferase 1 0.0133261
MYO19 myosin XIX 0.0133252
RAB40C RAB40C, member RAS oncogene family 0.0133152
GATD1 glutamine amidotransferase class 1 domain containing 1 0.0133011
WASF2 WAS protein family, member 2 0.0132931
AKAP13 A kinase (PRKA) anchor protein 13 0.013293
PROC protein C (inactivator of coagulation factors Va and VIIIa) 0.013262
SLC35B4 solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4 0.0132567
MCM4 minichromosome maintenance complex component 4 0.0132546
DDIAS DNA damage-induced apoptosis suppressor 0.0132488
PA2G4 proliferation-associated 2G4, 38kDa 0.0132381
SSR2 signal sequence receptor, beta (translocon-associated protein beta) 0.0132047
HEBP2 heme binding protein 2 0.0131684
CPNE1 copine I 0.0131308
TLE4 transducin-like enhancer of split 4 0.0131165
SIK3 SIK family kinase 3 0.0131091
RFK riboflavin kinase 0.0130751
OXNAD1 oxidoreductase NAD-binding domain containing 1 0.0130511
MBTPS1 membrane-bound transcription factor peptidase, site 1 0.0130407
LAPTM4A lysosomal protein transmembrane 4 alpha 0.0130101

decreased expression

Symbol Name Standardized Value
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.170178
PDE4D phosphodiesterase 4D, cAMP-specific -0.118161
THSD4 thrombospondin, type I, domain containing 4 -0.0907459
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0774085
EHBP1 EH domain binding protein 1 -0.0770949
BMPR1B bone morphogenetic protein receptor, type IB -0.0708298
TXNRD1 thioredoxin reductase 1 -0.0689866
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0689783
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0663719
ZBTB20 zinc finger and BTB domain containing 20 -0.0638589
MED13L mediator complex subunit 13-like -0.0612938
TCF12 transcription factor 12 -0.061078
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0610307
TTC28 tetratricopeptide repeat domain 28 -0.0572316
NRP1 neuropilin 1 -0.0568277
APP amyloid beta (A4) precursor protein -0.0565687
SLC35F3 solute carrier family 35, member F3 -0.0544356
AK1 adenylate kinase 1 -0.0539308
MCU mitochondrial calcium uniporter -0.053585
BCAS3 breast carcinoma amplified sequence 3 -0.0522765
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0510716
SRPK2 SRSF protein kinase 2 -0.0493607
MAML3 mastermind-like 3 (Drosophila) -0.0492098
FN1 fibronectin 1 -0.0481657
PTGR1 prostaglandin reductase 1 -0.0477367
PARD3B par-3 family cell polarity regulator beta -0.0470173
SPATS2 spermatogenesis associated, serine-rich 2 -0.0466006
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0459349
CHD9 chromodomain helicase DNA binding protein 9 -0.0459342
OSBPL10 oxysterol binding protein-like 10 -0.0455653
ARHGAP26 Rho GTPase activating protein 26 -0.0455548
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0453986
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0451975
BICC1 BicC family RNA binding protein 1 -0.0450021
PTPRM protein tyrosine phosphatase, receptor type, M -0.0448441
GCLC glutamate-cysteine ligase, catalytic subunit -0.0440803
ANKRD17 ankyrin repeat domain 17 -0.0432211
SMAD3 SMAD family member 3 -0.0428011
OLA1 Obg-like ATPase 1 -0.0422102
NFIA nuclear factor I/A -0.0403388
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0398004
PRKCA protein kinase C, alpha -0.0397614
CA12 carbonic anhydrase XII -0.0393096
PATJ PATJ crumbs cell polarity complex component -0.0392287
SQSTM1 sequestosome 1 -0.0389926
NCOA2 nuclear receptor coactivator 2 -0.0381473
FMNL2 formin-like 2 -0.0380345
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0379797
PSD3 pleckstrin and Sec7 domain containing 3 -0.0378767
CSNK2A2 casein kinase 2, alpha prime polypeptide -0.0372398
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0371046
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 -0.0369016
CNKSR3 CNKSR family member 3 -0.0368367
STK39 serine threonine kinase 39 -0.0366125
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0362727
GRAMD1A GRAM domain containing 1A -0.0358236
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0355812
NRCAM neuronal cell adhesion molecule -0.0355489
FNDC3B fibronectin type III domain containing 3B -0.0354268
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0350352
TMCC1 transmembrane and coiled-coil domain family 1 -0.0346678
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0343315
IRS2 insulin receptor substrate 2 -0.0340694
STK24 serine/threonine kinase 24 -0.0336398
SFXN5 sideroflexin 5 -0.0333996
RIN2 Ras and Rab interactor 2 -0.0330975
DAPK1 death-associated protein kinase 1 -0.0330294
BMPR1A bone morphogenetic protein receptor, type IA -0.0328132
RABGAP1 RAB GTPase activating protein 1 -0.0327292
OGA O-GlcNAcase -0.0325791
DENND4C DENN/MADD domain containing 4C -0.0324322
NCOA3 nuclear receptor coactivator 3 -0.0324303
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -0.0323911
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0323317
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 -0.0319463
DOCK10 dedicator of cytokinesis 10 -0.0319059
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 -0.0316679
FAF2 Fas associated factor family member 2 -0.0313524
SYT1 synaptotagmin I -0.0310472
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0309714
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0309511
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta -0.0305235
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0304816
PCDH9 protocadherin 9 -0.0303369
ACTG1 actin gamma 1 -0.0301636
PLCB4 phospholipase C, beta 4 -0.0301524
ETFA electron-transfer-flavoprotein, alpha polypeptide -0.0300407
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0299811
ABTB3 ankyrin repeat and BTB domain containing 3 -0.0297237
ATXN2 ataxin 2 -0.029624
TRIO trio Rho guanine nucleotide exchange factor -0.0295171
ITGB5 integrin, beta 5 -0.0287884
TENT2 terminal nucleotidyltransferase 2 -0.0287762
MORF4L1 mortality factor 4 like 1 -0.0286036
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0284804
ATXN1 ataxin 1 -0.028397
SESTD1 SEC14 and spectrin domains 1 -0.0282732
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0282696
BICD1 bicaudal D homolog 1 (Drosophila) -0.0279038
CELF1 CUGBP, Elav-like family member 1 -0.0278295
BIRC6 baculoviral IAP repeat containing 6 -0.0277285
MEF2A myocyte enhancer factor 2A -0.0276814
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0276493
RPTOR regulatory associated protein of MTOR, complex 1 -0.0275488
FRMD3 FERM domain containing 3 -0.0272925
WWP1 WW domain containing E3 ubiquitin protein ligase 1 -0.0272842
AGFG1 ArfGAP with FG repeats 1 -0.0272385
TANK TRAF family member-associated NFKB activator -0.0271064
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) -0.0270869
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0270343
LRP6 low density lipoprotein receptor-related protein 6 -0.0269835
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0269277
PTGES2 prostaglandin E synthase 2 -0.0268094
RPS19 ribosomal protein S19 -0.0267351
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0266105
TUT4 terminal uridylyl transferase 4 -0.0264988
TNRC6B trinucleotide repeat containing 6B -0.0264449
PTMS parathymosin -0.0264418
STX8 syntaxin 8 -0.0262596
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.0260247
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.0260214
DOCK5 dedicator of cytokinesis 5 -0.0259521
JARID2 jumonji, AT rich interactive domain 2 -0.0259245
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0258784
BABAM2 BRISC and BRCA1 A complex member 2 -0.0258516
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0258186
INO80 INO80 complex subunit -0.0257229
SNX1 sorting nexin 1 -0.0255598
MAP4 microtubule-associated protein 4 -0.0255579
USP9X ubiquitin specific peptidase 9, X-linked -0.0254681
RNF13 ring finger protein 13 -0.0250338
GABPB1 GA binding protein transcription factor, beta subunit 1 -0.025012
NRG1 neuregulin 1 -0.024926
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0246093
CEMIP2 cell migration inducing hyaluronidase 2 -0.024541
EVI5 ecotropic viral integration site 5 -0.0243736
TNPO1 transportin 1 -0.0243568
SYNJ2 synaptojanin 2 -0.0242505
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0242453
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0242215
TCF25 transcription factor 25 (basic helix-loop-helix) -0.0240573
WTAP Wilms tumor 1 associated protein -0.0240278
RFX3 regulatory factor X, 3 (influences HLA class II expression) -0.0239428
LMNA lamin A/C -0.0239423
STRN striatin, calmodulin binding protein -0.0239133
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0237042
ZFHX3 zinc finger homeobox 3 -0.0237032
FRMD5 FERM domain containing 5 -0.0236217
TM4SF4 transmembrane 4 L six family member 4 -0.0234406
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0234283
LRP10 low density lipoprotein receptor-related protein 10 -0.0233221
PACS1 phosphofurin acidic cluster sorting protein 1 -0.023305
RAB6A RAB6A, member RAS oncogene family -0.0233005
MBTD1 mbt domain containing 1 -0.0231807
EFL1 elongation factor like GTPase 1 -0.0231523
PUM2 pumilio RNA-binding family member 2 -0.0231394
TMED3 transmembrane emp24 protein transport domain containing 3 -0.0228014
IGFBP4 insulin-like growth factor binding protein 4 -0.0227604
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like -0.022633
TPT1 tumor protein, translationally-controlled 1 -0.0225994
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0225545
PM20D1 peptidase M20 domain containing 1 -0.0225438
ZFAND3 zinc finger, AN1-type domain 3 -0.022486
PDIA5 protein disulfide isomerase family A, member 5 -0.0224855
PHACTR4 phosphatase and actin regulator 4 -0.0224343
ZNF644 zinc finger protein 644 -0.022414
PTPRK protein tyrosine phosphatase, receptor type, K -0.0223968
RCOR1 REST corepressor 1 -0.0223813
UBAP1 ubiquitin associated protein 1 -0.0223424
DNAAF9 dynein axonemal assembly factor 9 -0.0223407
CLASP1 cytoplasmic linker associated protein 1 -0.0223235
ARHGAP24 Rho GTPase activating protein 24 -0.0222875
FER fer (fps/fes related) tyrosine kinase -0.0222873
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0221783
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 -0.0221449
RARB retinoic acid receptor, beta -0.0221209
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A -0.0221205
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) -0.0220663
METTL16 methyltransferase like 16 -0.0219357
EML2 echinoderm microtubule associated protein like 2 -0.0219094
R3HDM1 R3H domain containing 1 -0.0218491
PHF21A PHD finger protein 21A -0.0218438
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0218158
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0217077
SVIL supervillin -0.0216701
HELZ helicase with zinc finger -0.0216453
FBXO28 F-box protein 28 -0.0215982
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0215797
CAPZB capping protein (actin filament) muscle Z-line, beta -0.0215667
CPT1A carnitine palmitoyltransferase 1A (liver) -0.0215637
SEPTIN6 septin 6 -0.0215592
DPY30 dpy-30 homolog (C. elegans) -0.0214859
SLC30A9 solute carrier family 30 (zinc transporter), member 9 -0.0214403
MSI2 musashi RNA-binding protein 2 -0.0214039
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -0.0213907
WWOX WW domain containing oxidoreductase -0.0213774
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0213731
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0213689
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase -0.0213292
NLK nemo-like kinase -0.0213151
GRB10 growth factor receptor-bound protein 10 -0.0212893
NIPBL Nipped-B homolog (Drosophila) -0.0211984
AQR aquarius intron-binding spliceosomal factor -0.0211405
GOLGA4 golgin A4 -0.0210321
LAMA5 laminin, alpha 5 -0.0210267
MGLL monoglyceride lipase -0.0210219
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0208741
ARHGAP12 Rho GTPase activating protein 12 -0.0208298
MECP2 methyl CpG binding protein 2 -0.0207987
AGO3 argonaute RISC catalytic component 3 -0.0207815
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 -0.0206383
PDE8A phosphodiesterase 8A -0.020557
TFPI2 tissue factor pathway inhibitor 2 -0.0205556
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0205284
VPS35L VPS35 endosomal protein sorting factor like -0.0205095
FRS2 fibroblast growth factor receptor substrate 2 -0.0203826
USP25 ubiquitin specific peptidase 25 -0.0203679
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0202477
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0202209
ZNF652 zinc finger protein 652 -0.0202023
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0201794
MDN1 MDN1, midasin homolog (yeast) -0.0201213
ARHGAP17 Rho GTPase activating protein 17 -0.0201179
TRAPPC9 trafficking protein particle complex 9 -0.0200501
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0200461
AMBRA1 autophagy/beclin-1 regulator 1 -0.020009
SYT17 synaptotagmin XVII -0.0199346
LITAF lipopolysaccharide-induced TNF factor -0.01989
LOC112694756 uncharaterized LOC112694756 -0.0198709
TRA2B transformer 2 beta homolog (Drosophila) -0.0198624
ACBD5 acyl-CoA binding domain containing 5 -0.019854
HDLBP high density lipoprotein binding protein -0.0198361
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 -0.019724
CHMP4B charged multivesicular body protein 4B -0.0197166
SLC22A23 solute carrier family 22, member 23 -0.019664
AXL AXL receptor tyrosine kinase -0.0196461
ATP9A ATPase, class II, type 9A -0.0196416
USP32 ubiquitin specific peptidase 32 -0.0196117
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0196082
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0195749
CSDE1 cold shock domain containing E1, RNA-binding -0.0195601
SMG6 SMG6 nonsense mediated mRNA decay factor -0.0194998
C6ORF89 chromosome 6 open reading frame 89 -0.0194759
MYO18A myosin XVIIIA -0.0192473
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) -0.0192422
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) -0.0192225
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked -0.0192053
ZFX zinc finger protein, X-linked -0.0191965
RBM25 RNA binding motif protein 25 -0.0191818
BICRAL BICRA like chromatin remodeling complex associated protein -0.0191729
TNRC6A trinucleotide repeat containing 6A -0.019153
SLC45A4 solute carrier family 45, member 4 -0.0191466
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 -0.0191426
KYNU kynureninase -0.0191265
POC1B POC1 centriolar protein B -0.0191155
DUSP16 dual specificity phosphatase 16 -0.0191152
TLK2 tousled-like kinase 2 -0.0190523
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0190336
SGPP1 sphingosine-1-phosphate phosphatase 1 -0.0190271
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.019012
COL4A5 collagen, type IV, alpha 5 -0.0188221
TRAF3 TNF receptor-associated factor 3 -0.0188032
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0187864
CSNK1G3 casein kinase 1, gamma 3 -0.0187104
RNF24 ring finger protein 24 -0.018702
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0187005
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0186853
PKP4 plakophilin 4 -0.018682
ABHD2 abhydrolase domain containing 2 -0.0186761
GOLGB1 golgin B1 -0.0186632
YY1 YY1 transcription factor -0.0185855
LRRC28 leucine rich repeat containing 28 -0.0185529
RPS14 ribosomal protein S14 -0.0184991
ZFAND6 zinc finger, AN1-type domain 6 -0.0184312
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0183996
PHTF1 putative homeodomain transcription factor 1 -0.0183744
TBC1D22A TBC1 domain family, member 22A -0.018323
CUX1 cut-like homeobox 1 -0.018318
GLIS3 GLIS family zinc finger 3 -0.0182925
CNOT6 CCR4-NOT transcription complex, subunit 6 -0.0182858
FAR1 fatty acyl CoA reductase 1 -0.0182658
AGMO alkylglycerol monooxygenase -0.0182055
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) -0.0181944
CTBP2 C-terminal binding protein 2 -0.0181648
ZNF207 zinc finger protein 207 -0.0181525
EGFR epidermal growth factor receptor -0.018115
UBXN4 UBX domain protein 4 -0.0180902
RORA RAR-related orphan receptor A -0.0179906
CDC42SE2 CDC42 small effector 2 -0.017972
USP36 ubiquitin specific peptidase 36 -0.0179085
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0178736
TPGS1 tubulin polyglutamylase complex subunit 1 -0.0178497
HEXA hexosaminidase A (alpha polypeptide) -0.0178081
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0177927
GPHN gephyrin -0.0177439
ANAPC5 anaphase promoting complex subunit 5 -0.0177342
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0177176
GRID1 glutamate receptor, ionotropic, delta 1 -0.0176781
ESYT2 extended synaptotagmin-like protein 2 -0.0176655
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) -0.017615
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.0175129
NR1D2 nuclear receptor subfamily 1, group D, member 2 -0.0174768
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0173678
SH3D19 SH3 domain containing 19 -0.0173613
SLC38A2 solute carrier family 38, member 2 -0.0173567
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0173486
TNS3 tensin 3 -0.0173299
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0173168
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -0.0172392
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0172341
ERCC6L2 excision repair cross-complementation group 6-like 2 -0.0172169
SBF2 SET binding factor 2 -0.0171853
TENT4A terminal nucleotidyltransferase 4A -0.0171806
RANBP17 RAN binding protein 17 -0.0171776
LRP12 low density lipoprotein receptor-related protein 12 -0.0171545
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 -0.0171136
RPS17 ribosomal protein S17 -0.0170424
CDHR3 cadherin-related family member 3 -0.0170062
PPP1R13B protein phosphatase 1, regulatory subunit 13B -0.0169971
KIAA0319L KIAA0319-like -0.0169935
RC3H2 ring finger and CCCH-type domains 2 -0.016993
PECR peroxisomal trans-2-enoyl-CoA reductase -0.0169396
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0168941
SPAG9 sperm associated antigen 9 -0.0168877
ZSCAN5A zinc finger and SCAN domain containing 5A -0.0168619
TRNP1 TMF1-regulated nuclear protein 1 -0.0167647
MEGF9 multiple EGF-like-domains 9 -0.0167558
SNX5 sorting nexin 5 -0.016747
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 -0.0166946
UGP2 UDP-glucose pyrophosphorylase 2 -0.0166733
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase -0.0166313
ZNF277 zinc finger protein 277 -0.0166122
TYW5 tRNA-yW synthesizing protein 5 -0.0165617
ANXA13 annexin A13 -0.0165522
ILKAP integrin-linked kinase-associated serine/threonine phosphatase -0.0165336
KMT5B lysine methyltransferase 5B -0.016457
COX5A cytochrome c oxidase subunit Va -0.0164555
KANSL2 KAT8 regulatory NSL complex subunit 2 -0.016454
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 -0.0164439
COL4A6 collagen, type IV, alpha 6 -0.0164207
TBL1X transducin (beta)-like 1X-linked -0.0164143
HEATR3 HEAT repeat containing 3 -0.0163852
KHDC4 KH domain containing 4, pre-mRNA splicing factor -0.016379
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0163754
GTF2IRD1 GTF2I repeat domain containing 1 -0.0163548
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 -0.0163494
IL10RB interleukin 10 receptor, beta -0.0163199
H3-3B H3.3 histone B -0.0163075
LIMD1 LIM domains containing 1 -0.0162598
EXOC6 exocyst complex component 6 -0.0162555
TRIM37 tripartite motif containing 37 -0.0162543
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 -0.0162525
SPPL2A signal peptide peptidase like 2A -0.0162351
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase -0.0162207
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0161853
STK32B serine/threonine kinase 32B -0.0161592
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0161347
MRTO4 mRNA turnover 4 homolog (S. cerevisiae) -0.0161057
SCAF11 SR-related CTD-associated factor 11 -0.0160716
KIF3B kinesin family member 3B -0.0160557
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0160524
DENND4A DENN/MADD domain containing 4A -0.01604
ADD3 adducin 3 (gamma) -0.0159864
KLHL20 kelch-like family member 20 -0.0159713
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A -0.0159663
CARMIL1 capping protein regulator and myosin 1 linker 1 -0.015927
TMC5 transmembrane channel-like 5 -0.0158898
NUP155 nucleoporin 155kDa -0.0158886
COBLL1 cordon-bleu WH2 repeat protein-like 1 -0.0158819
PLCE1 phospholipase C, epsilon 1 -0.0158805
CARD8 caspase recruitment domain family, member 8 -0.0158631
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0158578
THOC2 THO complex 2 -0.0158534
PHKA2 phosphorylase kinase, alpha 2 (liver) -0.0158503
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0158007
CTPS2 CTP synthase 2 -0.0157919
PIGL phosphatidylinositol glycan anchor biosynthesis, class L -0.0157618
RPL7L1 ribosomal protein L7-like 1 -0.0157464
LASP1 LIM and SH3 protein 1 -0.0157141
RAB11FIP3 RAB11 family interacting protein 3 (class II) -0.0155984
PCNX4 pecanex 4 -0.0155907
RNF216 ring finger protein 216 -0.0155785
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0155472
LPP LIM domain containing preferred translocation partner in lipoma -0.0155461
THUMPD2 THUMP domain containing 2 -0.0154988
MPG N-methylpurine-DNA glycosylase -0.0154941
CEP85L centrosomal protein 85kDa-like -0.0154612
FOXP1 forkhead box P1 -0.0153848
RHOQ ras homolog family member Q -0.0153521
ATP5F1B ATP synthase F1 subunit beta -0.015347
SSH1 slingshot protein phosphatase 1 -0.0153442
RIC8B RIC8 guanine nucleotide exchange factor B -0.0152763
C2CD5 C2 calcium-dependent domain containing 5 -0.0152556
KTN1 kinectin 1 (kinesin receptor) -0.015249
MCM9 minichromosome maintenance complex component 9 -0.0152445
PPP6R2 protein phosphatase 6, regulatory subunit 2 -0.0152426
GRN granulin -0.0152406
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 -0.0152188
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0151945
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -0.0151728
CDK7 cyclin-dependent kinase 7 -0.01515
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 -0.0151335
MBNL1 muscleblind-like splicing regulator 1 -0.0150837
HNF1B HNF1 homeobox B -0.0150734
COX5B cytochrome c oxidase subunit Vb -0.0150533
MCTP1 multiple C2 domains, transmembrane 1 -0.0150501
LRRC23 leucine rich repeat containing 23 -0.0150497
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0150037
CEP170 centrosomal protein 170kDa -0.0149487
FAM107B family with sequence similarity 107, member B -0.0149347
HDGFL3 HDGF like 3 -0.0149302
FCHSD2 FCH and double SH3 domains 2 -0.014913
CARNMT1 carnosine N-methyltransferase 1 -0.014898
EBF1 early B-cell factor 1 -0.0148974
SCAF1 SR-related CTD-associated factor 1 -0.0148458
BAG6 BCL2-associated athanogene 6 -0.0148151
RBMX RNA binding motif protein, X-linked -0.0147858
TCEA1 transcription elongation factor A (SII), 1 -0.0147813
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit -0.0147492
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) -0.0147168
UBE2L3 ubiquitin-conjugating enzyme E2L 3 -0.014706
TMEM120B transmembrane protein 120B -0.014679
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 -0.0146709
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0146132
KDM7A lysine (K)-specific demethylase 7A -0.0145846
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0145813
HEATR1 HEAT repeat containing 1 -0.0145636
MPZL1 myelin protein zero-like 1 -0.0145491
CAND1 cullin-associated and neddylation-dissociated 1 -0.0145435
CPPED1 calcineurin-like phosphoesterase domain containing 1 -0.0145331
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0145301
ADPGK ADP-dependent glucokinase -0.0145295
GLE1 GLE1 RNA export mediator -0.0144901
PTEN phosphatase and tensin homolog -0.0144795
CRTC3 CREB regulated transcription coactivator 3 -0.0144632
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0144472
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0144327
NUMBL numb homolog (Drosophila)-like -0.0143984
MRPS34 mitochondrial ribosomal protein S34 -0.0143943
DST dystonin -0.0143943
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0143742
TP63 tumor protein p63 -0.0143576
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0143543
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -0.0143481
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0143456
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma -0.0143312
ANXA4 annexin A4 -0.0143134
UBE3C ubiquitin protein ligase E3C -0.0142995
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase -0.0142974
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) -0.0142849
DGKH diacylglycerol kinase, eta -0.0142623
CFH complement factor H -0.0142186
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0142016
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A -0.0142014
ZNRF3 zinc and ring finger 3 -0.0141936
MACROH2A1 macroH2A.1 histone -0.0141889
RNF115 ring finger protein 115 -0.0141652
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0141449
TBC1D16 TBC1 domain family, member 16 -0.0141311
PDE7A phosphodiesterase 7A -0.014082
FHIT fragile histidine triad -0.0140811
ARHGAP5 Rho GTPase activating protein 5 -0.0140806
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 -0.0140382
RGS3 regulator of G-protein signaling 3 -0.0139754
CNBP CCHC-type zinc finger, nucleic acid binding protein -0.0139701
RAB1A RAB1A, member RAS oncogene family -0.0139225
FGD4 FYVE, RhoGEF and PH domain containing 4 -0.0139084
ZFP64 ZFP64 zinc finger protein -0.0138836
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -0.013874
PTK2 protein tyrosine kinase 2 -0.0138557
SRSF10 serine/arginine-rich splicing factor 10 -0.0138412
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0138275
LMCD1 LIM and cysteine-rich domains 1 -0.0138235
MEIS3 Meis homeobox 3 -0.0138224
THADA thyroid adenoma associated -0.0138111
UBE2H ubiquitin-conjugating enzyme E2H -0.0137923
DPF2 D4, zinc and double PHD fingers family 2 -0.0137852
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0137749
CDC123 cell division cycle 123 -0.0137564
MLXIP MLX interacting protein -0.013753
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0137305
MELTF melanotransferrin -0.0137235
SWAP70 SWAP switching B-cell complex 70kDa subunit -0.0137066
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -0.0136986
UTRN utrophin -0.0136968
PAWR PRKC, apoptosis, WT1, regulator -0.0136884
CXORF38 chromosome X open reading frame 38 -0.0136813
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -0.0136788
ETV6 ets variant 6 -0.0136713
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 -0.013655
AZIN1 antizyme inhibitor 1 -0.013633
KIFC3 kinesin family member C3 -0.013627
SPIDR scaffolding protein involved in DNA repair -0.0136089
SOD2 superoxide dismutase 2, mitochondrial -0.0136029
ABHD3 abhydrolase domain containing 3 -0.0135849
TMEM267 transmembrane protein 267 -0.0135776
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0135748
RNF215 ring finger protein 215 -0.0135677
PRSS23 protease, serine, 23 -0.0135537
KIF1C kinesin family member 1C -0.0135476