A549_GSK-LSD1 2HCl_1µM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description GSK-LSD1 2HCl 1µM perturbation in A549 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the A549_GSK-LSD1 2HCl_1µM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
KRT8 keratin 8, type II 0.185004
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.143463
FTL ferritin, light polypeptide 0.135141
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.120126
KRT18 keratin 18, type I 0.0928155
AKR1C1 aldo-keto reductase family 1, member C1 0.0732184
AKR1C2 aldo-keto reductase family 1, member C2 0.0695486
FADS2 fatty acid desaturase 2 0.0663312
RRBP1 ribosome binding protein 1 0.0654571
BSG basigin (Ok blood group) 0.0634151
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.0634046
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0620861
ENO1 enolase 1, (alpha) 0.0606565
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0585459
ACACA acetyl-CoA carboxylase alpha 0.0572554
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0567869
CANX calnexin 0.0559031
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0556698
AGR2 anterior gradient 2 0.052435
CTSD cathepsin D 0.0518404
RPLP1 ribosomal protein, large, P1 0.0509726
MAP4 microtubule-associated protein 4 0.0481258
TPI1 triosephosphate isomerase 1 0.0473202
CENPF centromere protein F, 350/400kDa 0.0467294
TUBB tubulin, beta class I 0.0464003
TUBA1B tubulin, alpha 1b 0.0462421
TRIO trio Rho guanine nucleotide exchange factor 0.0452961
MTUS1 microtubule associated tumor suppressor 1 0.0452866
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0421256
POTEF POTE ankyrin domain family, member F 0.0420556
DOCK5 dedicator of cytokinesis 5 0.0410283
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0407373
KIF5B kinesin family member 5B 0.0404344
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0403077
LDHA lactate dehydrogenase A 0.0402484
PUM3 pumilio RNA binding family member 3 0.0393116
RPS3 ribosomal protein S3 0.0390003
LOC112694756 uncharaterized LOC112694756 0.0388837
LDLR low density lipoprotein receptor 0.0372518
PLCE1 phospholipase C, epsilon 1 0.0372181
MKI67 marker of proliferation Ki-67 0.0371745
PKM pyruvate kinase, muscle 0.0371397
MAP1B microtubule-associated protein 1B 0.0368305
S100A6 S100 calcium binding protein A6 0.0366604
CCND3 cyclin D3 0.0365098
FOXP1 forkhead box P1 0.0362241
S100A10 S100 calcium binding protein A10 0.0361925
FLNA filamin A, alpha 0.0359476
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0350841
PDE4B phosphodiesterase 4B, cAMP-specific 0.0348797
LMNA lamin A/C 0.0347841
UBTF upstream binding transcription factor, RNA polymerase I 0.0345213
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0342731
DHCR24 24-dehydrocholesterol reductase 0.0340157
DIAPH1 diaphanous-related formin 1 0.0328124
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0327047
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.0326377
VIM vimentin 0.0323268
RPL15 ribosomal protein L15 0.0322394
UBA2 ubiquitin-like modifier activating enzyme 2 0.0315663
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 0.0314167
CCDC57 coiled-coil domain containing 57 0.031037
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 0.0308979
KIF21A kinesin family member 21A 0.0306018
VCL vinculin 0.0305449
RPS4X ribosomal protein S4, X-linked 0.0303047
RPS9 ribosomal protein S9 0.0300604
PHACTR4 phosphatase and actin regulator 4 0.0299558
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0298559
RANBP2 RAN binding protein 2 0.0297666
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.02971
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.0291459
RPL8 ribosomal protein L8 0.0288091
LMAN2 lectin, mannose-binding 2 0.0287666
VGLL4 vestigial-like family member 4 0.0287166
HELLS helicase, lymphoid-specific 0.0287131
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0286761
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.0286615
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0286407
TMCC1 transmembrane and coiled-coil domain family 1 0.0285751
GCLM glutamate-cysteine ligase, modifier subunit 0.0284127
ACBD6 acyl-CoA binding domain containing 6 0.0283664
RTN3 reticulon 3 0.0282252
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0281737
RPS19 ribosomal protein S19 0.0279495
KTN1 kinectin 1 (kinesin receptor) 0.0278626
UBE2Z ubiquitin-conjugating enzyme E2Z 0.0278498
ACLY ATP citrate lyase 0.0277783
ATP13A3 ATPase type 13A3 0.0274834
STAU2 staufen double-stranded RNA binding protein 2 0.0270628
ANXA2 annexin A2 0.027042
DHCR7 7-dehydrocholesterol reductase 0.0270389
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.0269133
DEK DEK proto-oncogene 0.0268348
SYCP2 synaptonemal complex protein 2 0.0267925
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa 0.0266933
MYOF myoferlin 0.0265159
PFN1 profilin 1 0.0264723
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 0.0264581
TUFM Tu translation elongation factor, mitochondrial 0.0263993
LBR lamin B receptor 0.0263671
ZFAND3 zinc finger, AN1-type domain 3 0.026294
S100A4 S100 calcium binding protein A4 0.0262476
RPL27A ribosomal protein L27a 0.0262302
XPO1 exportin 1 0.0261005
SIL1 SIL1 nucleotide exchange factor 0.025959
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0258599
UBL4A ubiquitin-like 4A 0.0257883
CREB1 cAMP responsive element binding protein 1 0.0257102
LRP10 low density lipoprotein receptor-related protein 10 0.0256446
PTMS parathymosin 0.0255758
SEC23IP SEC23 interacting protein 0.0254086
GPX2 glutathione peroxidase 2 0.0253488
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.0253291
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0252625
ARHGAP26 Rho GTPase activating protein 26 0.0252465
CDC37 cell division cycle 37 0.0252129
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0252022
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0251079
FBXO34 F-box protein 34 0.0250147
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae) 0.0248948
PRPF8 pre-mRNA processing factor 8 0.0247131
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 0.0247078
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.024674
UBB ubiquitin B 0.0245099
CHEK2 checkpoint kinase 2 0.0243824
CREBBP CREB binding protein 0.0243439
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa 0.0241043
MARK2 MAP/microtubule affinity-regulating kinase 2 0.0240661
TARBP1 TAR (HIV-1) RNA binding protein 1 0.023912
MBOAT7 membrane bound O-acyltransferase domain containing 7 0.0238359
GCN1 GCN1 activator of EIF2AK4 0.0237879
KATNBL1 katanin p80 subunit B-like 1 0.023761
RPS29 ribosomal protein S29 0.0236476
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0235702
GSTP1 glutathione S-transferase pi 1 0.0234504
LMNB2 lamin B2 0.0234113
IGF2R insulin-like growth factor 2 receptor 0.0233973
CD151 CD151 molecule (Raph blood group) 0.0233855
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 0.0232505
TMEM97 transmembrane protein 97 0.0232428
FTH1 ferritin, heavy polypeptide 1 0.0232321
APRT adenine phosphoribosyltransferase 0.0231933
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0231212
HOMER2 homer scaffolding protein 2 0.0231156
FKBP4 FK506 binding protein 4, 59kDa 0.0229469
AKR1C3 aldo-keto reductase family 1, member C3 0.0228782
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 0.0228752
ATP5MJ ATP synthase membrane subunit j 0.022769
TMEM117 transmembrane protein 117 0.0226225
PAWR PRKC, apoptosis, WT1, regulator 0.022561
SCMH1 sex comb on midleg homolog 1 (Drosophila) 0.0224855
TJP1 tight junction protein 1 0.0224545
BIRC6 baculoviral IAP repeat containing 6 0.0223823
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) 0.0222854
PRDX1 peroxiredoxin 1 0.0222373
PCSK6 proprotein convertase subtilisin/kexin type 6 0.0222082
RPL5 ribosomal protein L5 0.0222023
SFT2D2 SFT2 domain containing 2 0.0220956
RBM10 RNA binding motif protein 10 0.0220305
GRB2 growth factor receptor-bound protein 2 0.022018
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 0.0219224
IER3 immediate early response 3 0.021854
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0218054
ATXN2 ataxin 2 0.0216794
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0216355
STAG2 stromal antigen 2 0.0216286
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0215488
RPS25 ribosomal protein S25 0.0215114
RPH3AL rabphilin 3A-like (without C2 domains) 0.0214281
NCAPD2 non-SMC condensin I complex, subunit D2 0.0214174
CEP290 centrosomal protein 290kDa 0.0214088
PLEKHA6 pleckstrin homology domain containing, family A member 6 0.0213822
CDC50A cell division cycle 50 P4-ATPase accessory subunit A 0.0213774
TMSB10 thymosin beta 10 0.0213391
RPL12 ribosomal protein L12 0.0212848
RNF111 ring finger protein 111 0.0212355
ITPRIPL2 inositol 1,4,5-trisphosphate receptor interacting protein-like 2 0.0212343
PRRC2B proline-rich coiled-coil 2B 0.0212238
PPP6R2 protein phosphatase 6, regulatory subunit 2 0.021201
ADAM17 ADAM metallopeptidase domain 17 0.0211764
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0211464
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0211392
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0211219
KIF16B kinesin family member 16B 0.0210663
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0210117
PUS7 pseudouridylate synthase 7 (putative) 0.0210061
SLC4A2 solute carrier family 4 (anion exchanger), member 2 0.0209614
ACTN1 actinin, alpha 1 0.0209017
ILF3 interleukin enhancer binding factor 3, 90kDa 0.0208868
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0208759
CTNND1 catenin (cadherin-associated protein), delta 1 0.0208128
TXN2 thioredoxin 2 0.0207779
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0207748
CUL3 cullin 3 0.0207638
EDARADD EDAR-associated death domain 0.0206128
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0206112
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 0.0205915
XXYLT1 xyloside xylosyltransferase 1 0.0205281
SCAF1 SR-related CTD-associated factor 1 0.020506
GJD3 gap junction protein, delta 3, 31.9kDa 0.0204386
LRIF1 ligand dependent nuclear receptor interacting factor 1 0.0204309
RSL1D1 ribosomal L1 domain containing 1 0.0204034
LCLAT1 lysocardiolipin acyltransferase 1 0.0203458
SNRPA small nuclear ribonucleoprotein polypeptide A 0.0203124
MTDH metadherin 0.0203096
ERBIN erbb2 interacting protein 0.0203089
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0203046
SELENOS selenoprotein S 0.0202356
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0202108
RYBP RING1 and YY1 binding protein 0.0201989
ATL2 atlastin GTPase 2 0.020198
MMS22L MMS22-like, DNA repair protein 0.0201677
NEBL nebulette 0.0201604
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G 0.0201353
RPS21 ribosomal protein S21 0.0200633
RASAL2 RAS protein activator like 2 0.0200587
SLC38A10 solute carrier family 38, member 10 0.0200048
SHLD1 shieldin complex subunit 1 0.0199903
RSF1 remodeling and spacing factor 1 0.0199801
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0199702
MARCHF6 membrane associated ring-CH-type finger 6 0.0199655
TIMD4 T-cell immunoglobulin and mucin domain containing 4 0.0199264
GANAB glucosidase, alpha; neutral AB 0.0198891
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 0.019813
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0197952
GPHN gephyrin 0.0196761
ATE1 arginyltransferase 1 0.019649
BCAP31 B-cell receptor-associated protein 31 0.0195663
RDX radixin 0.0195527
WNT7B wingless-type MMTV integration site family, member 7B 0.0195059
AGFG1 ArfGAP with FG repeats 1 0.0194838
NUDCD3 NudC domain containing 3 0.019482
PRSS3 protease, serine, 3 0.0194637
TOB1 transducer of ERBB2, 1 0.0194576
CYCS cytochrome c, somatic 0.0193904
NOP56 NOP56 ribonucleoprotein 0.0192824
LARP4 La ribonucleoprotein domain family, member 4 0.019264
MRPS34 mitochondrial ribosomal protein S34 0.0192636
DLG1 discs, large homolog 1 (Drosophila) 0.0192514
IPO9 importin 9 0.0192316
SMAD3 SMAD family member 3 0.0191939
NUP153 nucleoporin 153kDa 0.0191216
COG5 component of oligomeric golgi complex 5 0.0190584
FAM120A family with sequence similarity 120A 0.0190528
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 0.019052
RAN RAN, member RAS oncogene family 0.0190315
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.0189856
FNBP4 formin binding protein 4 0.0189814
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 0.0188593
PDXK pyridoxal (pyridoxine, vitamin B6) kinase 0.018797
CTBP2 C-terminal binding protein 2 0.0187721
IARS1 isoleucyl-tRNA synthetase 1 0.0187327
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.0186703
NSD3 nuclear receptor binding SET domain protein 3 0.0186075
DAD1 defender against cell death 1 0.0185885
PTPRM protein tyrosine phosphatase, receptor type, M 0.0185587
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 0.0183789
KMT5B lysine methyltransferase 5B 0.0183038
MTMR14 myotubularin related protein 14 0.0182703
TMED5 transmembrane emp24 protein transport domain containing 5 0.0182693
PRC1 protein regulator of cytokinesis 1 0.0182678
RPL10A ribosomal protein L10a 0.0181951
CNKSR3 CNKSR family member 3 0.0181625
STX5 syntaxin 5 0.0180974
KIAA1671 KIAA1671 0.0180284
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.0179842
MRFAP1 Morf4 family associated protein 1 0.017963
TRIM28 tripartite motif containing 28 0.0179575
TRAM1 translocation associated membrane protein 1 0.0179266
TBC1D4 TBC1 domain family, member 4 0.017925
IGF1R insulin-like growth factor 1 receptor 0.0178777
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0178718
SREBF1 sterol regulatory element binding transcription factor 1 0.017861
POFUT4 protein O-fucosyltransferase 4 0.0178602
ZNF235 zinc finger protein 235 0.0178222
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0177604
LMF2 lipase maturation factor 2 0.0176425
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 0.0175905
MAP7D1 MAP7 domain containing 1 0.0175232
ACTG1 actin gamma 1 0.0173756
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0173337
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0173233
WDR20 WD repeat domain 20 0.0173048
ITGB5 integrin, beta 5 0.0172468
KRT7 keratin 7, type II 0.0172092
GPX8 glutathione peroxidase 8 (putative) 0.0171953
DIAPH2 diaphanous-related formin 2 0.0171189
ERP29 endoplasmic reticulum protein 29 0.0171051
CCT8 chaperonin containing TCP1, subunit 8 (theta) 0.017021
SYT1 synaptotagmin I 0.0169754
LIN7A lin-7 homolog A (C. elegans) 0.0168955
PTOV1 prostate tumor overexpressed 1 0.0168907
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 0.016879
WDR70 WD repeat domain 70 0.0168348
TBCD tubulin folding cofactor D 0.0168187
TCP1 t-complex 1 0.0168119
BICD1 bicaudal D homolog 1 (Drosophila) 0.0168007
MORF4L2 mortality factor 4 like 2 0.0167993
SSRP1 structure specific recognition protein 1 0.0167913
PGRMC1 progesterone receptor membrane component 1 0.016789
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) 0.016767
RNF149 ring finger protein 149 0.0167298
ATL3 atlastin GTPase 3 0.0166905
ENC1 ectodermal-neural cortex 1 (with BTB domain) 0.0166822
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 0.0166718
ERMP1 endoplasmic reticulum metallopeptidase 1 0.0166646
R3HDM1 R3H domain containing 1 0.0165402
RUSF1 RUS family member 1 0.0165243
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0164971
RPL34 ribosomal protein L34 0.0164753
LRRC58 leucine rich repeat containing 58 0.0164537
SLC38A2 solute carrier family 38, member 2 0.0164509
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa 0.0164051
M6PR mannose-6-phosphate receptor (cation dependent) 0.0164028
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 0.0163839
ANXA4 annexin A4 0.0163775
MSN moesin 0.0163498
CHCHD10 coiled-coil-helix-coiled-coil-helix domain containing 10 0.0163479
RAD21 RAD21 homolog (S. pombe) 0.0163235
JAK1 Janus kinase 1 0.0163019
ATP5F1E ATP synthase F1 subunit epsilon 0.0162834
GLS2 glutaminase 2 (liver, mitochondrial) 0.016281
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0162637
PTER phosphotriesterase related 0.0162613
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.01626
SEC22C SEC22 vesicle trafficking protein homolog C (S. cerevisiae) 0.0162533
SHTN1 shootin 1 0.0162475
ZNF668 zinc finger protein 668 0.0162366
MPZL1 myelin protein zero-like 1 0.0162309
MAP2K1 mitogen-activated protein kinase kinase 1 0.0162272
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 0.0161834
IL6ST interleukin 6 signal transducer 0.0161754
FHIT fragile histidine triad 0.0161684
SOGA1 suppressor of glucose, autophagy associated 1 0.0161418
TGFBI transforming growth factor, beta-induced, 68kDa 0.0160883
MYO6 myosin VI 0.0160564
GDI2 GDP dissociation inhibitor 2 0.0160274
PDE7B phosphodiesterase 7B 0.0160069
RPL7 ribosomal protein L7 0.015985
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.0159263
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0158852
UQCRC2 ubiquinol-cytochrome c reductase core protein II 0.0158586
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0157964
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase 0.0157578
NSD2 nuclear receptor binding SET domain protein 2 0.0157576
RECQL RecQ helicase-like 0.0156965
NAMPT nicotinamide phosphoribosyltransferase 0.015684
IGFBP3 insulin-like growth factor binding protein 3 0.0156595
EIF1 eukaryotic translation initiation factor 1 0.0156492
CD2AP CD2-associated protein 0.0156414
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0155936
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0155637
SLC35E3 solute carrier family 35, member E3 0.015549
SSBP1 single-stranded DNA binding protein 1, mitochondrial 0.0155185
PRKD2 protein kinase D2 0.015472
GOLGB1 golgin B1 0.0154473
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.015439
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2 0.0154254
UBQLN1 ubiquilin 1 0.015384
SCARB2 scavenger receptor class B, member 2 0.0153644
MGME1 mitochondrial genome maintenance exonuclease 1 0.0153594
NHSL3 NHS like 3 0.0153232
CDK8 cyclin-dependent kinase 8 0.0152696
RPS6 ribosomal protein S6 0.015245
MGST1 microsomal glutathione S-transferase 1 0.0152409
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0152283
ZEB1 zinc finger E-box binding homeobox 1 0.0152106
KIAA1549 KIAA1549 0.0151608
ARHGAP21 Rho GTPase activating protein 21 0.0151424
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0151228
MAPRE2 microtubule-associated protein, RP/EB family, member 2 0.0151068
PARVB parvin, beta 0.0150995
GPBP1 GC-rich promoter binding protein 1 0.0150975
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 0.0150946
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26 0.0150812
ATOX1 antioxidant 1 copper chaperone 0.0150783
SFTPA2 surfactant protein A2 0.0150715
FYCO1 FYVE and coiled-coil domain containing 1 0.0150568
SYNGR2 synaptogyrin 2 0.0150238
EIPR1 EARP complex and GARP complex interacting protein 1 0.0150222
TM4SF1 transmembrane 4 L six family member 1 0.0150209
SERF2 small EDRK-rich factor 2 0.0149536
ITGAV integrin, alpha V 0.0149426
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing 0.0149374
NAP1L1 nucleosome assembly protein 1-like 1 0.014909
C1ORF159 chromosome 1 open reading frame 159 0.014818
ZDHHC5 zinc finger, DHHC-type containing 5 0.0147949
DOCK1 dedicator of cytokinesis 1 0.0147898
PRKCSH protein kinase C substrate 80K-H 0.0147791
RSPO3 R-spondin 3 0.0147547
ZBTB1 zinc finger and BTB domain containing 1 0.0147348
TMTC3 transmembrane and tetratricopeptide repeat containing 3 0.014723
AGO3 argonaute RISC catalytic component 3 0.0146934
KLHL18 kelch-like family member 18 0.0146764
NAT8 N-acetyltransferase 8 (GCN5-related, putative) 0.0146757
WDR1 WD repeat domain 1 0.0146596
ATP5MF ATP synthase membrane subunit f 0.0146485
HP1BP3 heterochromatin protein 1, binding protein 3 0.0146326
VDAC3 voltage-dependent anion channel 3 0.0146249
LSG1 large 60S subunit nuclear export GTPase 1 0.0146018
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0145933
LCMT1 leucine carboxyl methyltransferase 1 0.0145552
CHD3 chromodomain helicase DNA binding protein 3 0.0145547
BORCS5 BLOC-1 related complex subunit 5 0.0145166
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0144882
BRD3 bromodomain containing 3 0.0144401
RABGAP1L RAB GTPase activating protein 1-like 0.0143841
PPP5C protein phosphatase 5, catalytic subunit 0.0143625
CNOT10 CCR4-NOT transcription complex, subunit 10 0.0143512
TMED3 transmembrane emp24 protein transport domain containing 3 0.014337
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0142611
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 0.0142582
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0142336
CLEC16A C-type lectin domain family 16, member A 0.014222
TFPI2 tissue factor pathway inhibitor 2 0.0142103
USP22 ubiquitin specific peptidase 22 0.0142024
JADE1 jade family PHD finger 1 0.0141774
NCKAP1 NCK-associated protein 1 0.0141767
UBE2S ubiquitin-conjugating enzyme E2S 0.0141313
POU2F1 POU class 2 homeobox 1 0.0141215
SLC35F6 solute carrier family 35, member F6 0.0141172
ZFR zinc finger RNA binding protein 0.0140991
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0140743
B2M beta-2-microglobulin 0.0140515
GRID1 glutamate receptor, ionotropic, delta 1 0.014042
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0140371
HRNR hornerin 0.0139981
CD24 CD24 molecule 0.0139886
TRAM2 translocation associated membrane protein 2 0.0139822
TONSL tonsoku-like, DNA repair protein 0.0139774
ARHGAP11A Rho GTPase activating protein 11A 0.0139706
CLINT1 clathrin interactor 1 0.0139653
NRF1 nuclear respiratory factor 1 0.0139507
AHNAK AHNAK nucleoprotein 0.0139426
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0139357
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.0139166
FAM120B family with sequence similarity 120B 0.0139071
CYP2S1 cytochrome P450, family 2, subfamily S, polypeptide 1 0.0138905
CEP128 centrosomal protein 128kDa 0.0138862
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0138814
COMMD1 copper metabolism (Murr1) domain containing 1 0.0138225
EEF2 eukaryotic translation elongation factor 2 0.0138161
FASN fatty acid synthase 0.013804
METTL6 methyltransferase like 6 0.0137907
OPN3 opsin 3 0.0137797
VPS25 vacuolar protein sorting 25 homolog (S. cerevisiae) 0.0137235
ZFTRAF1 zinc finger TRAF-type containing 1 0.0137113
LETMD1 LETM1 domain containing 1 0.0137071
TMEM120B transmembrane protein 120B 0.0136831
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0136788
H2AZ2 H2A.Z variant histone 2 0.0136512
STMN1 stathmin 1 0.0136482
NDUFAF2 NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 0.0136362
CORO2A coronin, actin binding protein, 2A 0.0136246
GFOD1 glucose-fructose oxidoreductase domain containing 1 0.0135868
NTAQ1 N-terminal glutamine amidase 1 0.0135745
DZIP3 DAZ interacting zinc finger protein 3 0.0135382
ARHGAP35 Rho GTPase activating protein 35 0.0135322
XRRA1 X-ray radiation resistance associated 1 0.0135247
DSPP dentin sialophosphoprotein 0.0135214
AP2S1 adaptor-related protein complex 2, sigma 1 subunit 0.0135184
ZNHIT1 zinc finger, HIT-type containing 1 0.0135031
RBBP6 retinoblastoma binding protein 6 0.0134989
TPM2 tropomyosin 2 (beta) 0.0134818
STAT5B signal transducer and activator of transcription 5B 0.0134459
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) 0.0134335
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0134194
ABHD12 abhydrolase domain containing 12 0.0134143
MUSK muscle, skeletal, receptor tyrosine kinase 0.0134143
CNST consortin, connexin sorting protein 0.0133937
PCNA proliferating cell nuclear antigen 0.0133924
LARP1 La ribonucleoprotein domain family, member 1 0.0133833
SIRT7 sirtuin 7 0.0133725
GRK5 G protein-coupled receptor kinase 5 0.0133611
EIF4E2 eukaryotic translation initiation factor 4E family member 2 0.0133504
TRAPPC9 trafficking protein particle complex 9 0.0133482
BPTF bromodomain PHD finger transcription factor 0.0133333
RPL35A ribosomal protein L35a 0.0133165
GCFC2 GC-rich sequence DNA-binding factor 2 0.0133057
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 0.0132977
STXBP1 syntaxin binding protein 1 0.0132925
C6ORF62 chromosome 6 open reading frame 62 0.0132784
PICALM phosphatidylinositol binding clathrin assembly protein 0.0132511
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0132409
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae) 0.0132236
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0132067
DTD1 D-tyrosyl-tRNA deacylase 1 0.0131998
STAMBP STAM binding protein 0.0131888
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.0131857
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 0.0131666
BLTP3B bridge-like lipid transfer protein family member 3B 0.013165
SKP1 S-phase kinase-associated protein 1 0.0131552
STEAP3 STEAP family member 3, metalloreductase 0.0131513
AMMECR1L AMMECR1-like 0.0131487
RAI1 retinoic acid induced 1 0.0131467
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0131258
RAD23A RAD23 homolog A (S. cerevisiae) 0.0130782
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0130711
ENOX2 ecto-NOX disulfide-thiol exchanger 2 0.0130679

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.142016
MYO1E myosin IE -0.104507
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.103393
THSD4 thrombospondin, type I, domain containing 4 -0.0975852
NRG1 neuregulin 1 -0.0690187
PTGR1 prostaglandin reductase 1 -0.0664053
PCDH9 protocadherin 9 -0.0651819
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0643514
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0571277
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0570464
MCU mitochondrial calcium uniporter -0.0558291
CUX1 cut-like homeobox 1 -0.0539265
PDE10A phosphodiesterase 10A -0.0531719
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0519381
PARD3 par-3 family cell polarity regulator -0.0503887
ZNF609 zinc finger protein 609 -0.0497096
CNTNAP3B contactin associated protein-like 3B -0.049658
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0489596
BMPR1B bone morphogenetic protein receptor, type IB -0.0483902
NUMB numb homolog (Drosophila) -0.0481505
BCAS3 breast carcinoma amplified sequence 3 -0.0473229
ZBTB20 zinc finger and BTB domain containing 20 -0.0472621
RNF213 ring finger protein 213 -0.0466677
CA12 carbonic anhydrase XII -0.0457871
PDE8A phosphodiesterase 8A -0.0451853
CNTN1 contactin 1 -0.0450593
SCAF11 SR-related CTD-associated factor 11 -0.0449772
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0447774
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0430845
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0427327
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0426425
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0426405
MED13L mediator complex subunit 13-like -0.0415524
RAB10 RAB10, member RAS oncogene family -0.040858
JMJD1C jumonji domain containing 1C -0.040721
TXNRD1 thioredoxin reductase 1 -0.0405358
NCOA2 nuclear receptor coactivator 2 -0.039981
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0399384
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0387501
PTPRA protein tyrosine phosphatase, receptor type, A -0.0386447
EFNA5 ephrin-A5 -0.037828
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -0.0378163
SPAG9 sperm associated antigen 9 -0.0375275
PLD3 phospholipase D family, member 3 -0.0372898
GMDS GDP-mannose 4,6-dehydratase -0.0370114
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0367995
HDLBP high density lipoprotein binding protein -0.0367531
PDLIM5 PDZ and LIM domain 5 -0.0365425
PHF21A PHD finger protein 21A -0.0365086
PATJ PATJ crumbs cell polarity complex component -0.0361088
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0355012
SIK3 SIK family kinase 3 -0.0354643
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0345674
SQSTM1 sequestosome 1 -0.0345311
BCL2L1 BCL2-like 1 -0.0344686
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0343777
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) -0.034273
OGA O-GlcNAcase -0.03424
STK24 serine/threonine kinase 24 -0.0339567
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0339163
YAP1 Yes-associated protein 1 -0.0337547
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 -0.0337049
NCOR1 nuclear receptor corepressor 1 -0.033678
SSH2 slingshot protein phosphatase 2 -0.0336698
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0335993
CHD9 chromodomain helicase DNA binding protein 9 -0.0335763
AFF1 AF4/FMR2 family, member 1 -0.033545
EXT1 exostosin glycosyltransferase 1 -0.0332511
NPAS2 neuronal PAS domain protein 2 -0.032957
CEMIP2 cell migration inducing hyaluronidase 2 -0.0329192
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0326755
GPATCH2L G patch domain containing 2-like -0.0326624
KANK1 KN motif and ankyrin repeat domains 1 -0.0324239
MPG N-methylpurine-DNA glycosylase -0.0323579
COPA coatomer protein complex, subunit alpha -0.0322913
DGKD diacylglycerol kinase, delta 130kDa -0.03202
RBM47 RNA binding motif protein 47 -0.0319529
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.031943
SLTM SAFB-like, transcription modulator -0.0312103
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 -0.0312097
EXOC6 exocyst complex component 6 -0.0311298
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0310162
MYADM myeloid-associated differentiation marker -0.0310076
RUSC2 RUN and SH3 domain containing 2 -0.030959
SOAT1 sterol O-acyltransferase 1 -0.0307246
PRKCA protein kinase C, alpha -0.0306103
CERS6 ceramide synthase 6 -0.0305523
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.0305443
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0303426
NTN4 netrin 4 -0.0303254
SPIDR scaffolding protein involved in DNA repair -0.0301624
RAD51B RAD51 paralog B -0.0299855
TBL1X transducin (beta)-like 1X-linked -0.0299488
AAGAB alpha- and gamma-adaptin binding protein -0.029939
EZR ezrin -0.0292611
MAML3 mastermind-like 3 (Drosophila) -0.0290173
EBF1 early B-cell factor 1 -0.0289811
SEC11A SEC11 homolog A (S. cerevisiae) -0.028978
TCF20 transcription factor 20 (AR1) -0.0288004
RPLP0 ribosomal protein, large, P0 -0.0287831
SYNRG synergin, gamma -0.0286372
STRN3 striatin, calmodulin binding protein 3 -0.0282792
CYRIB CYFIP related Rac1 interactor B -0.0282101
TOM1L2 target of myb1-like 2 (chicken) -0.0280575
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0280317
PCDHB16 protocadherin beta 16 -0.0279019
C5 complement component 5 -0.0277793
SETBP1 SET binding protein 1 -0.0277501
FAM193A family with sequence similarity 193, member A -0.0276874
SLC35F3 solute carrier family 35, member F3 -0.0276091
TP63 tumor protein p63 -0.0275747
FOXK1 forkhead box K1 -0.0275138
SEPTIN6 septin 6 -0.027508
TCF12 transcription factor 12 -0.0275054
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0273013
SRSF4 serine/arginine-rich splicing factor 4 -0.0271387
HACD3 3-hydroxyacyl-CoA dehydratase 3 -0.0270707
SPATS2 spermatogenesis associated, serine-rich 2 -0.0268207
BRMS1L breast cancer metastasis-suppressor 1-like -0.0267949
NF1 neurofibromin 1 -0.0267653
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0267336
SMC6 structural maintenance of chromosomes 6 -0.0267312
NHSL1 NHS-like 1 -0.0265316
BRWD1 bromodomain and WD repeat domain containing 1 -0.0264566
MBNL1 muscleblind-like splicing regulator 1 -0.026307
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0263051
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0261831
SLC38A1 solute carrier family 38, member 1 -0.0261245
BABAM2 BRISC and BRCA1 A complex member 2 -0.0261239
AARS1 alanyl-tRNA synthetase 1 -0.0260748
PSPH phosphoserine phosphatase -0.0259684
FRMD3 FERM domain containing 3 -0.0259249
DYM dymeclin -0.0259119
GON4L gon-4-like (C. elegans) -0.025849
ABLIM1 actin binding LIM protein 1 -0.0258289
ZBTB4 zinc finger and BTB domain containing 4 -0.0256888
PPP4R1 protein phosphatase 4, regulatory subunit 1 -0.0256527
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0256139
CDC27 cell division cycle 27 -0.0255777
ZFHX3 zinc finger homeobox 3 -0.0254906
RNF145 ring finger protein 145 -0.0254826
ZNF644 zinc finger protein 644 -0.0254451
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) -0.0254332
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0253887
COP1 COP1 E3 ubiquitin ligase -0.025261
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0251499
SLC39A11 solute carrier family 39, member 11 -0.0251338
DAPK1 death-associated protein kinase 1 -0.0250616
GTF2IRD1 GTF2I repeat domain containing 1 -0.0249067
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34 -0.0248142
PLCH1 phospholipase C, eta 1 -0.0247684
RBM39 RNA binding motif protein 39 -0.0246942
MAPK6 mitogen-activated protein kinase 6 -0.0246231
ATOSA atos homolog A -0.0245887
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.024402
BICC1 BicC family RNA binding protein 1 -0.0243479
LARP4B La ribonucleoprotein domain family, member 4B -0.0241499
CP ceruloplasmin (ferroxidase) -0.023968
RACK1 receptor for activated C kinase 1 -0.023918
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.0239119
USP34 ubiquitin specific peptidase 34 -0.02382
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0236965
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0236053
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0233352
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0233047
RBM6 RNA binding motif protein 6 -0.0232457
PERP PERP, TP53 apoptosis effector -0.0232017
ITSN1 intersectin 1 (SH3 domain protein) -0.0231564
ASPH aspartate beta-hydroxylase -0.0231386
SPPL3 signal peptide peptidase like 3 -0.0230681
AK1 adenylate kinase 1 -0.0229624
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0229482
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 -0.0229236
TANK TRAF family member-associated NFKB activator -0.0229079
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0228063
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0227829
CCNI cyclin I -0.0227223
TBC1D5 TBC1 domain family, member 5 -0.022581
CMIP c-Maf inducing protein -0.0225225
PTPRK protein tyrosine phosphatase, receptor type, K -0.0225166
GSR glutathione reductase -0.0224444
METTL16 methyltransferase like 16 -0.0223574
TTC17 tetratricopeptide repeat domain 17 -0.0223569
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) -0.0223064
TASOR2 transcription activation suppressor family member 2 -0.0222021
DNMBP dynamin binding protein -0.0221329
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0220899
PGM2L1 phosphoglucomutase 2-like 1 -0.0220882
STIM1 stromal interaction molecule 1 -0.0220522
TACC2 transforming, acidic coiled-coil containing protein 2 -0.0219547
SDCCAG8 serologically defined colon cancer antigen 8 -0.0218964
AUH AU RNA binding protein/enoyl-CoA hydratase -0.0218813
FBXO11 F-box protein 11 -0.0218699
CAMKMT calmodulin-lysine N-methyltransferase -0.0218347
KMT2E lysine (K)-specific methyltransferase 2E -0.0217362
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0217086
FAM222B family with sequence similarity 222, member B -0.0216412
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 -0.0216088
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 -0.0215767
EPB41 erythrocyte membrane protein band 4.1 -0.021567
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0215555
PITRM1 pitrilysin metallopeptidase 1 -0.0215077
CNTNAP3 contactin associated protein-like 3 -0.0212852
AVL9 AVL9 homolog (S. cerevisiase) -0.0212721
TMEM65 transmembrane protein 65 -0.0212665
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant -0.021238
IRS2 insulin receptor substrate 2 -0.0212324
BTBD7 BTB (POZ) domain containing 7 -0.0211927
WDR59 WD repeat domain 59 -0.0211571
MLPH melanophilin -0.021059
AUTS2 autism susceptibility candidate 2 -0.0210321
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa -0.0210019
WWTR1 WW domain containing transcription regulator 1 -0.0209836
PPARG peroxisome proliferator-activated receptor gamma -0.020956
ZFAND6 zinc finger, AN1-type domain 6 -0.0209495
AP3D1 adaptor-related protein complex 3, delta 1 subunit -0.0209368
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0209325
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0209319
MYO9A myosin IXA -0.0208991
ATXN3 ataxin 3 -0.0208388
MICU1 mitochondrial calcium uptake 1 -0.0208188
PARD3B par-3 family cell polarity regulator beta -0.0208097
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.020769
CNOT6 CCR4-NOT transcription complex, subunit 6 -0.0205947
SFXN5 sideroflexin 5 -0.020589
ZBTB38 zinc finger and BTB domain containing 38 -0.0205263
IGSF1 immunoglobulin superfamily, member 1 -0.0204979
THADA thyroid adenoma associated -0.0204716
ZNF148 zinc finger protein 148 -0.0204463
ZFC3H1 zinc finger, C3H1-type containing -0.0204105
TMEM41B transmembrane protein 41B -0.0204023
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 -0.0203646
PDPR pyruvate dehydrogenase phosphatase regulatory subunit -0.0203336
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0203225
CALD1 caldesmon 1 -0.0202795
GPR135 G protein-coupled receptor 135 -0.0202406
SOS1 son of sevenless homolog 1 (Drosophila) -0.0201775
XRN2 5'-3' exoribonuclease 2 -0.0201537
MPHOSPH9 M-phase phosphoprotein 9 -0.0201034
NLN neurolysin (metallopeptidase M3 family) -0.0200657
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 -0.0200502
WDR12 WD repeat domain 12 -0.0199511
SH3PXD2A SH3 and PX domains 2A -0.019941
ZC3H3 zinc finger CCCH-type containing 3 -0.0198775
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0198657
NIPSNAP2 nipsnap homolog 2 -0.0198605
INTS6 integrator complex subunit 6 -0.0198336
MPRIP myosin phosphatase Rho interacting protein -0.0197948
TRA2A transformer 2 alpha homolog (Drosophila) -0.0197123
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 -0.0197122
HNRNPL heterogeneous nuclear ribonucleoprotein L -0.0196132
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -0.0195838
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0195675
USP36 ubiquitin specific peptidase 36 -0.0195341
FILIP1 filamin A interacting protein 1 -0.0193637
SMIM44 small integral membrane protein 44 -0.0193016
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0192217
EXOC4 exocyst complex component 4 -0.019192
SBF2 SET binding factor 2 -0.0191756
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) -0.0191334
KLHL5 kelch-like family member 5 -0.0190926
PLIN3 perilipin 3 -0.0190924
CKAP4 cytoskeleton-associated protein 4 -0.0190824
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A -0.0190659
CHD1L chromodomain helicase DNA binding protein 1-like -0.0189408
IST1 increased sodium tolerance 1 homolog (yeast) -0.0189356
PLCB4 phospholipase C, beta 4 -0.018935
ZBTB35 zinc finger and BTB domain containing 35 -0.0188893
RPAP2 RNA polymerase II associated protein 2 -0.0188443
FXYD5 FXYD domain containing ion transport regulator 5 -0.0188201
CALU calumenin -0.0188189
GCC2 GRIP and coiled-coil domain containing 2 -0.0187262
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.0187246
SEC31A SEC31 homolog A (S. cerevisiae) -0.0187153
SEC63 SEC63 homolog (S. cerevisiae) -0.0186977
NEK9 NIMA-related kinase 9 -0.0186761
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) -0.0186585
CTPS2 CTP synthase 2 -0.0186262
ARID1A AT rich interactive domain 1A (SWI-like) -0.0186103
OPHN1 oligophrenin 1 -0.018578
GDNF glial cell derived neurotrophic factor -0.0185676
PITPNA phosphatidylinositol transfer protein, alpha -0.0184923
ASTN2 astrotactin 2 -0.0184753
KIF11 kinesin family member 11 -0.0184732
PUM2 pumilio RNA-binding family member 2 -0.01847
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) -0.0184604
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.01846
SINHCAF SIN3-HDAC complex associated factor -0.0184407
KIF3C kinesin family member 3C -0.0183794
BMERB1 bMERB domain containing 1 -0.0182415
ZFX zinc finger protein, X-linked -0.0182234
PALLD palladin, cytoskeletal associated protein -0.018179
MYH9 myosin, heavy chain 9, non-muscle -0.0181702
DNAAF9 dynein axonemal assembly factor 9 -0.0181388
IGBP1 immunoglobulin (CD79A) binding protein 1 -0.0180823
EML4 echinoderm microtubule associated protein like 4 -0.0180442
MYLIP myosin regulatory light chain interacting protein -0.0180123
PLS1 plastin 1 -0.0179933
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 -0.0179585
RAB1A RAB1A, member RAS oncogene family -0.0179482
MAP2K5 mitogen-activated protein kinase kinase 5 -0.0179466
MEIS2 Meis homeobox 2 -0.017936
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0179237
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2 -0.0179177
AXL AXL receptor tyrosine kinase -0.0178874
RNF4 ring finger protein 4 -0.0178763
MCM9 minichromosome maintenance complex component 9 -0.017868
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0177227
TTL tubulin tyrosine ligase -0.0176689
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) -0.0176637
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0176466
RFX2 regulatory factor X, 2 (influences HLA class II expression) -0.0176441
LPP LIM domain containing preferred translocation partner in lipoma -0.0175513
APP amyloid beta (A4) precursor protein -0.0175138
RAB22A RAB22A, member RAS oncogene family -0.0175058
THRAP3 thyroid hormone receptor associated protein 3 -0.0174369
CHKA choline kinase alpha -0.0174012
ZNF367 zinc finger protein 367 -0.0173982
RABAC1 Rab acceptor 1 (prenylated) -0.0173854
IFT88 intraflagellar transport 88 -0.0173697
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -0.0173647
CARMIL1 capping protein regulator and myosin 1 linker 1 -0.0173446
ACOT9 acyl-CoA thioesterase 9 -0.0173192
DENND5B DENN/MADD domain containing 5B -0.0173047
YIPF4 Yip1 domain family, member 4 -0.017287
DOCK4 dedicator of cytokinesis 4 -0.0172484
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -0.0172436
NFIB nuclear factor I/B -0.0172019
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 -0.0171904
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0171768
MAP7 microtubule-associated protein 7 -0.0171739
RRAS2 related RAS viral (r-ras) oncogene homolog 2 -0.0171604
CHD8 chromodomain helicase DNA binding protein 8 -0.0171381
KDM3B lysine (K)-specific demethylase 3B -0.0171131
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit -0.0171105
RPS17 ribosomal protein S17 -0.0170937
ZNF75A zinc finger protein 75a -0.0170682
LIPH lipase, member H -0.0170664
PARG poly (ADP-ribose) glycohydrolase -0.0170647
KDM5B lysine (K)-specific demethylase 5B -0.0170562
PLD5 phospholipase D family, member 5 -0.0170551
LAMB1 laminin, beta 1 -0.0170159
FRMD5 FERM domain containing 5 -0.0169988
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 -0.0169941
PDLIM1 PDZ and LIM domain 1 -0.0169781
EP300 E1A binding protein p300 -0.0169153
REEP3 receptor accessory protein 3 -0.0168993
HPCAL1 hippocalcin-like 1 -0.0168929
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) -0.0168677
KIAA1217 KIAA1217 -0.0168589
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0168451
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.016841
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0168319
DNASE1 deoxyribonuclease I -0.0168315
WWC1 WW and C2 domain containing 1 -0.016796
ARHGAP18 Rho GTPase activating protein 18 -0.0167749
CRTC3 CREB regulated transcription coactivator 3 -0.0167651
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 -0.0167578
IFT43 intraflagellar transport 43 -0.0167459
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0166924
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0166293
CCDC47 coiled-coil domain containing 47 -0.0166195
CYFIP1 cytoplasmic FMR1 interacting protein 1 -0.0166122
MACROD2 MACRO domain containing 2 -0.0165869
ARMH3 armadillo like helical domain containing 3 -0.0165588
ATAD2B ATPase family, AAA domain containing 2B -0.0165489
GNB5 guanine nucleotide binding protein (G protein), beta 5 -0.0165345
ATP9B ATPase, class II, type 9B -0.0165186
KATNIP katanin interacting protein -0.0165182
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0165082
POC1B POC1 centriolar protein B -0.0164925
FBXL18 F-box and leucine-rich repeat protein 18 -0.0164894
DGUOK deoxyguanosine kinase -0.0164526
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0164221
CDK12 cyclin-dependent kinase 12 -0.0163886
OSBPL10 oxysterol binding protein-like 10 -0.0163847
DUSP16 dual specificity phosphatase 16 -0.0163816
MZT2A mitotic spindle organizing protein 2A -0.0163396
PPP1R12B protein phosphatase 1, regulatory subunit 12B -0.0162965
LMBR1 limb development membrane protein 1 -0.0162723
DCAF7 DDB1 and CUL4 associated factor 7 -0.0162403
RAB6A RAB6A, member RAS oncogene family -0.0162077
LPCAT3 lysophosphatidylcholine acyltransferase 3 -0.0161979
LYRM4 LYR motif containing 4 -0.0161947
AQR aquarius intron-binding spliceosomal factor -0.0161659
RBM23 RNA binding motif protein 23 -0.0161278
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -0.0161271
ABHD18 abhydrolase domain containing 18 -0.0161054
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) -0.0161036
CACNG8 calcium channel, voltage-dependent, gamma subunit 8 -0.0161032
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0160905
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) -0.0160452
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 -0.0160294
CHD7 chromodomain helicase DNA binding protein 7 -0.0160117
LATS1 large tumor suppressor kinase 1 -0.0160095
CREM cAMP responsive element modulator -0.0159956
FN1 fibronectin 1 -0.0159895
RANBP10 RAN binding protein 10 -0.0159817
CEP170 centrosomal protein 170kDa -0.015964
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -0.0159563
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 -0.0159272
SLC35B4 solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4 -0.0158947
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0158831
CTNNBL1 catenin, beta like 1 -0.0158489
BCAS1 breast carcinoma amplified sequence 1 -0.0158455
COASY CoA synthase -0.0158042
TPM3 tropomyosin 3 -0.0158014
KLHDC10 kelch domain containing 10 -0.0157935
PXDN peroxidasin -0.0157724
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta -0.0157704
TCP11L1 t-complex 11, testis-specific-like 1 -0.0157688
SEC23A Sec23 homolog A (S. cerevisiae) -0.0157526
ARL15 ADP-ribosylation factor-like 15 -0.0157514
MEF2A myocyte enhancer factor 2A -0.0157391
HNRNPM heterogeneous nuclear ribonucleoprotein M -0.0157202
LTBP1 latent transforming growth factor beta binding protein 1 -0.0157112
NCOR2 nuclear receptor corepressor 2 -0.0156972
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0156967
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.015691
JPT1 Jupiter microtubule associated homolog 1 -0.0156806
ALMS1 Alstrom syndrome protein 1 -0.0156785
WDFY3 WD repeat and FYVE domain containing 3 -0.0156247
VPS35L VPS35 endosomal protein sorting factor like -0.0156233
TOPBP1 topoisomerase (DNA) II binding protein 1 -0.0156228
GTF2IRD2B GTF2I repeat domain containing 2B -0.0156179
NFIA nuclear factor I/A -0.0155781
TOR1AIP2 torsin A interacting protein 2 -0.0155612
UBE2H ubiquitin-conjugating enzyme E2H -0.0154969
CMTM6 CKLF-like MARVEL transmembrane domain containing 6 -0.0154951
NCOA6 nuclear receptor coactivator 6 -0.0154408
MLXIP MLX interacting protein -0.0154213
ATXN1 ataxin 1 -0.0154056
SESTD1 SEC14 and spectrin domains 1 -0.0153841
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) -0.0153518
ACOT11 acyl-CoA thioesterase 11 -0.0153197
RNASEH1 ribonuclease H1 -0.0153093
UBE2E1 ubiquitin-conjugating enzyme E2E 1 -0.0152878
TOP1 topoisomerase (DNA) I -0.0152793
HSPB1 heat shock 27kDa protein 1 -0.015276
FOXN3 forkhead box N3 -0.015242
SPATA7 spermatogenesis associated 7 -0.0152234
RASA2 RAS p21 protein activator 2 -0.0151754
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0151677
ZNF236 zinc finger protein 236 -0.0151324
HOXB3 homeobox B3 -0.015113
ARSL arylsulfatase L -0.0150627
NUP205 nucleoporin 205kDa -0.0150526
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0150423
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0150352
ERCC1 excision repair cross-complementation group 1 -0.0149961
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 -0.0149566
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0149397
WDFY2 WD repeat and FYVE domain containing 2 -0.0148981
FDPS farnesyl diphosphate synthase -0.0148945
RPS27L ribosomal protein S27-like -0.0148908
CPNE1 copine I -0.0148884
SCAMP3 secretory carrier membrane protein 3 -0.0148782
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -0.0148778
LAMP2 lysosomal-associated membrane protein 2 -0.0148718
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0148407
GPATCH8 G patch domain containing 8 -0.0147744
CCDC6 coiled-coil domain containing 6 -0.0147634
DHX33 DEAH (Asp-Glu-Ala-His) box polypeptide 33 -0.0147483
TMEM161B transmembrane protein 161B -0.0147249
KIF1B kinesin family member 1B -0.014705
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit -0.0146868
IQSEC2 IQ motif and Sec7 domain 2 -0.0146623
CDK13 cyclin-dependent kinase 13 -0.0146573
ITFG2 integrin alpha FG-GAP repeat containing 2 -0.0146573
REST RE1-silencing transcription factor -0.0146524
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 -0.0146326
NOSTRIN nitric oxide synthase trafficking -0.014605
FMNL2 formin-like 2 -0.0146032
CNTLN centlein, centrosomal protein -0.0145666
ADGRA3 adhesion G protein-coupled receptor A3 -0.0145663
FGB fibrinogen beta chain -0.0145372
AGTPBP1 ATP/GTP binding protein 1 -0.014495
PDE9A phosphodiesterase 9A -0.0144849
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0144847
SLC30A9 solute carrier family 30 (zinc transporter), member 9 -0.0144613
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0144547
RAB1B RAB1B, member RAS oncogene family -0.0144022
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0143961
CAVIN1 caveolae associated protein 1 -0.0143899
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 -0.0143505
RPS5 ribosomal protein S5 -0.0143324
ARHGAP42 Rho GTPase activating protein 42 -0.014331
NOTCH3 notch 3 -0.0143179
TMEM59 transmembrane protein 59 -0.0142824
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0142673
BTBD9 BTB (POZ) domain containing 9 -0.0142653
RAB7A RAB7A, member RAS oncogene family -0.0142617
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase -0.0142557
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -0.0142508
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0142383
ING5 inhibitor of growth family, member 5 -0.0142355
RABGAP1 RAB GTPase activating protein 1 -0.0142001
PPA2 pyrophosphatase (inorganic) 2 -0.0141961
MTCL1 microtubule crosslinking factor 1 -0.0141874
JARID2 jumonji, AT rich interactive domain 2 -0.0141724