A549_GSK-LSD1 2HCl_10µM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description GSK-LSD1 2HCl 10µM perturbation in A549 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the A549_GSK-LSD1 2HCl_10µM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide 0.220459
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.160498
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.138935
KRT8 keratin 8, type II 0.136372
GPX2 glutathione peroxidase 2 0.113879
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.104387
MUSK muscle, skeletal, receptor tyrosine kinase 0.100865
AKR1C3 aldo-keto reductase family 1, member C3 0.0934839
PKM pyruvate kinase, muscle 0.0906914
AGR2 anterior gradient 2 0.0897743
IGFBP4 insulin-like growth factor binding protein 4 0.0845751
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0733839
RAB10 RAB10, member RAS oncogene family 0.0724066
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0689712
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0677838
FN1 fibronectin 1 0.0655639
AKR1C1 aldo-keto reductase family 1, member C1 0.0636604
FTH1 ferritin, heavy polypeptide 1 0.0613609
FADS2 fatty acid desaturase 2 0.0600778
KRT18 keratin 18, type I 0.0570999
UBL4A ubiquitin-like 4A 0.0513369
LRP10 low density lipoprotein receptor-related protein 10 0.0507007
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0504156
NCOA3 nuclear receptor coactivator 3 0.0493923
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0488261
AHNAK2 AHNAK nucleoprotein 2 0.0477132
RPS2 ribosomal protein S2 0.0458531
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0456367
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0451897
CALR calreticulin 0.0450652
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0417609
SYNE2 spectrin repeat containing, nuclear envelope 2 0.041399
CA12 carbonic anhydrase XII 0.0406586
LDLR low density lipoprotein receptor 0.0403329
MPRIP myosin phosphatase Rho interacting protein 0.0400247
CTSD cathepsin D 0.0395527
AKR1C2 aldo-keto reductase family 1, member C2 0.0388819
CD151 CD151 molecule (Raph blood group) 0.0388652
SSR2 signal sequence receptor, beta (translocon-associated protein beta) 0.0386682
BRI3BP BRI3 binding protein 0.0385948
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0375436
TRAM1 translocation associated membrane protein 1 0.0373841
USP9X ubiquitin specific peptidase 9, X-linked 0.0371332
NUP98 nucleoporin 98kDa 0.0368322
SDC1 syndecan 1 0.0367439
S100A6 S100 calcium binding protein A6 0.036208
TM4SF4 transmembrane 4 L six family member 4 0.0357338
MGST3 microsomal glutathione S-transferase 3 0.0354232
MLEC malectin 0.0353744
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0351936
MAP1B microtubule-associated protein 1B 0.0346062
CBX5 chromobox homolog 5 0.0344089
CNTN1 contactin 1 0.0343129
CST3 cystatin C 0.0342867
RPL15 ribosomal protein L15 0.0339474
CAPNS1 calpain, small subunit 1 0.0335774
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0334257
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0330183
MAST2 microtubule associated serine/threonine kinase 2 0.0327371
IGF1R insulin-like growth factor 1 receptor 0.0324548
TM4SF1 transmembrane 4 L six family member 1 0.0322246
LDHA lactate dehydrogenase A 0.0319769
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.031942
RPL37A ribosomal protein L37a 0.0312221
RPL23 ribosomal protein L23 0.0302465
MEGF8 multiple EGF-like-domains 8 0.0301823
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0298317
IKBIP IKBKB interacting protein 0.0290528
BSG basigin (Ok blood group) 0.028793
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 0.0278813
TM4SF20 transmembrane 4 L six family member 20 0.0278305
SHTN1 shootin 1 0.0278278
ARSD arylsulfatase D 0.0272905
PHB1 prohibitin 1 0.0268843
CD81 CD81 molecule 0.026758
ITM2B integral membrane protein 2B 0.0265336
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0264402
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0263861
ENO1 enolase 1, (alpha) 0.0262306
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.026089
KIF3C kinesin family member 3C 0.0260374
RPLP1 ribosomal protein, large, P1 0.0260248
TSKU tsukushi, small leucine rich proteoglycan 0.0259943
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0258385
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0255818
CYP2S1 cytochrome P450, family 2, subfamily S, polypeptide 1 0.0254303
PDZD8 PDZ domain containing 8 0.0254032
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa 0.0253519
DSG2 desmoglein 2 0.0251859
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0249811
ASPH aspartate beta-hydroxylase 0.0249504
NAP1L4 nucleosome assembly protein 1-like 4 0.024679
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.024472
HCFC1 host cell factor C1 0.024388
PCYOX1 prenylcysteine oxidase 1 0.024311
PDIA6 protein disulfide isomerase family A, member 6 0.0242835
LOC112694756 uncharaterized LOC112694756 0.024279
DIAPH1 diaphanous-related formin 1 0.0242544
ADIPOR2 adiponectin receptor 2 0.0239453
CDC50A cell division cycle 50 P4-ATPase accessory subunit A 0.023908
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit 0.0237871
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 0.0235855
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa 0.0235472
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0234268
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.023424
SFTPA2 surfactant protein A2 0.0233804
STAU2 staufen double-stranded RNA binding protein 2 0.023201
H3-3B H3.3 histone B 0.0231317
PDS5B PDS5 cohesin associated factor B 0.0231272
RNF213 ring finger protein 213 0.023112
PLPP1 phospholipid phosphatase 1 0.0230966
SPINT2 serine peptidase inhibitor, Kunitz type, 2 0.0230716
RTN4 reticulon 4 0.0230303
NRCAM neuronal cell adhesion molecule 0.0229169
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0227178
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0226725
SERINC3 serine incorporator 3 0.022573
CCDC88A coiled-coil domain containing 88A 0.022544
CD59 CD59 molecule, complement regulatory protein 0.0225098
SLC35F5 solute carrier family 35, member F5 0.0222719
PRRC2C proline-rich coiled-coil 2C 0.0222595
PTMS parathymosin 0.0221888
BASP1 brain abundant, membrane attached signal protein 1 0.0220858
MGST1 microsomal glutathione S-transferase 1 0.022041
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0216111
ZFHX3 zinc finger homeobox 3 0.0215916
TOB1 transducer of ERBB2, 1 0.0215429
EEF2 eukaryotic translation elongation factor 2 0.0214269
AAK1 AP2 associated kinase 1 0.02141
TMEM131 transmembrane protein 131 0.0213456
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0212904
MAP7 microtubule-associated protein 7 0.0210969
ABHD12 abhydrolase domain containing 12 0.0210549
SAMD5 sterile alpha motif domain containing 5 0.0210351
MSH3 mutS homolog 3 0.0208053
PIR pirin (iron-binding nuclear protein) 0.020764
AUP1 ancient ubiquitous protein 1 0.0206891
MRPS5 mitochondrial ribosomal protein S5 0.0206667
DEK DEK proto-oncogene 0.020647
NCEH1 neutral cholesterol ester hydrolase 1 0.0206166
EVA1C eva-1 homolog C (C. elegans) 0.0205955
ACADVL acyl-CoA dehydrogenase, very long chain 0.0204606
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0204066
APLP2 amyloid beta (A4) precursor-like protein 2 0.0203853
MAGED1 melanoma antigen family D1 0.0203132
ARHGAP11B Rho GTPase activating protein 11B 0.0202896
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0201858
PDS5A PDS5 cohesin associated factor A 0.020151
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 0.0200777
CNTLN centlein, centrosomal protein 0.0200357
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae) 0.0199713
RPS4X ribosomal protein S4, X-linked 0.0198524
SMIM44 small integral membrane protein 44 0.0198096
MSI2 musashi RNA-binding protein 2 0.0198076
UBE2M ubiquitin-conjugating enzyme E2M 0.0197608
KPNB1 karyopherin (importin) beta 1 0.019719
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.0197047
EPS8 epidermal growth factor receptor pathway substrate 8 0.0196717
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0195674
CLTC clathrin, heavy chain (Hc) 0.019558
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0195254
TPM3 tropomyosin 3 0.0194925
THRB thyroid hormone receptor, beta 0.0194502
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0193528
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0193121
YIF1B Yip1 interacting factor homolog B (S. cerevisiae) 0.0192896
UBE2H ubiquitin-conjugating enzyme E2H 0.0192856
NEB nebulin 0.0192655
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.0191791
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 0.0191754
SH3D19 SH3 domain containing 19 0.0191284
LY6E lymphocyte antigen 6 complex, locus E 0.0191159
LRIF1 ligand dependent nuclear receptor interacting factor 1 0.0190893
GPATCH8 G patch domain containing 8 0.0190755
RPS19 ribosomal protein S19 0.01904
ZNF251 zinc finger protein 251 0.0189395
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 0.0189209
TP53I3 tumor protein p53 inducible protein 3 0.0188559
GCLM glutamate-cysteine ligase, modifier subunit 0.0186974
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0186718
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0185429
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0184502
AFTPH aftiphilin 0.0184157
XBP1 X-box binding protein 1 0.0184032
CLASP1 cytoplasmic linker associated protein 1 0.0183373
KIF21A kinesin family member 21A 0.0183004
IDI1 isopentenyl-diphosphate delta isomerase 1 0.0182941
CYRIB CYFIP related Rac1 interactor B 0.0182902
RPL30 ribosomal protein L30 0.0182294
HACD3 3-hydroxyacyl-CoA dehydratase 3 0.018171
FMN1 formin 1 0.0181559
MACROD2 MACRO domain containing 2 0.0181525
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 0.0181295
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.0180851
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 0.0180642
BICDL1 BICD family like cargo adaptor 1 0.0180525
ZNF280D zinc finger protein 280D 0.0180169
CEP350 centrosomal protein 350kDa 0.0180052
STOM stomatin 0.0179172
CLDN2 claudin 2 0.0179131
LCLAT1 lysocardiolipin acyltransferase 1 0.0179087
PUM1 pumilio RNA-binding family member 1 0.0179082
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0179051
DNA2 DNA replication helicase/nuclease 2 0.0178704
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0177845
MYO1B myosin IB 0.0177488
MYH9 myosin, heavy chain 9, non-muscle 0.0177375
RPL7 ribosomal protein L7 0.0177351
MSRB3 methionine sulfoxide reductase B3 0.0176916
ABHD2 abhydrolase domain containing 2 0.0176763
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0176678
S100A4 S100 calcium binding protein A4 0.0176212
ENAH enabled homolog (Drosophila) 0.0176037
NELFCD negative elongation factor complex member C/D 0.0175939
GCN1 GCN1 activator of EIF2AK4 0.0175899
HSPA4 heat shock 70kDa protein 4 0.0175854
SNRPA small nuclear ribonucleoprotein polypeptide A 0.0175804
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 0.0175794
ABTB3 ankyrin repeat and BTB domain containing 3 0.0175754
TMEM106B transmembrane protein 106B 0.0175448
SMYD4 SET and MYND domain containing 4 0.0174974
TOMM70 translocase of outer mitochondrial membrane 70 0.0174335
RPS17 ribosomal protein S17 0.0174291
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0173886
SPATA6L spermatogenesis associated 6-like 0.017352
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.0173483
KIAA1549 KIAA1549 0.0173366
RNF24 ring finger protein 24 0.017299
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 0.0172491
NUP88 nucleoporin 88kDa 0.017233
TPM4 tropomyosin 4 0.0172001
FAM91A1 family with sequence similarity 91, member A1 0.0171991
ATP5MC2 ATP synthase membrane subunit c locus 2 0.0171902
GANAB glucosidase, alpha; neutral AB 0.0170935
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0170846
JUP junction plakoglobin 0.0170761
CYB5B cytochrome b5 type B (outer mitochondrial membrane) 0.017028
PDIA3 protein disulfide isomerase family A, member 3 0.017001
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 0.0168784
CCND3 cyclin D3 0.0168584
STAG2 stromal antigen 2 0.0168271
DHX30 DEAH (Asp-Glu-Ala-His) box helicase 30 0.0167786
KIF18B kinesin family member 18B 0.0167486
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.0167152
PAPOLA poly(A) polymerase alpha 0.0166257
FRK fyn-related Src family tyrosine kinase 0.0165426
SLC38A10 solute carrier family 38, member 10 0.0165358
STRBP spermatid perinuclear RNA binding protein 0.0165342
NRM nurim (nuclear envelope membrane protein) 0.0165087
ARHGAP24 Rho GTPase activating protein 24 0.0164931
WBP11 WW domain binding protein 11 0.0164907
KMT2A lysine (K)-specific methyltransferase 2A 0.0164453
PHYKPL 5-phosphohydroxy-L-lysine phospho-lyase 0.0164351
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) 0.016367
PLEKHA6 pleckstrin homology domain containing, family A member 6 0.0163631
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 0.0163157
TASP1 taspase, threonine aspartase, 1 0.0162683
OSGIN2 oxidative stress induced growth inhibitor family member 2 0.0162078
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0162003
GSTK1 glutathione S-transferase kappa 1 0.0161934
FBXW11 F-box and WD repeat domain containing 11 0.0161897
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.0161783
RDX radixin 0.0161761
RPL8 ribosomal protein L8 0.0160955
G6PC3 glucose 6 phosphatase, catalytic, 3 0.0160461
TUT4 terminal uridylyl transferase 4 0.0160392
PIAS1 protein inhibitor of activated STAT, 1 0.0160277
LAMP1 lysosomal-associated membrane protein 1 0.0159932
WBP1L WW domain binding protein 1-like 0.0159148
CEP250 centrosomal protein 250kDa 0.0159117
IL6ST interleukin 6 signal transducer 0.0158742
MAPK14 mitogen-activated protein kinase 14 0.0158507
NOP56 NOP56 ribonucleoprotein 0.0158159
CD46 CD46 molecule, complement regulatory protein 0.0157703
ARRB2 arrestin, beta 2 0.0157529
SYNGR2 synaptogyrin 2 0.0157437
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0157298
GMCL1 germ cell-less, spermatogenesis associated 1 0.0157202
RPL35 ribosomal protein L35 0.0157155
TBC1D4 TBC1 domain family, member 4 0.0156819
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 0.0156731
S100A10 S100 calcium binding protein A10 0.0156316
SPRED2 sprouty-related, EVH1 domain containing 2 0.0156099
YEATS2 YEATS domain containing 2 0.0155712
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 0.0154942
NCKAP1 NCK-associated protein 1 0.0154857
SEPTIN11 septin 11 0.0154747
GRB2 growth factor receptor-bound protein 2 0.0154432
GSK3B glycogen synthase kinase 3 beta 0.015413
CADPS2 Ca++-dependent secretion activator 2 0.0154061
CARMIL1 capping protein regulator and myosin 1 linker 1 0.0153874
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0153858
TNPO3 transportin 3 0.0153794
PITPNA phosphatidylinositol transfer protein, alpha 0.0153062
TAPBP TAP binding protein (tapasin) 0.0152473
MELTF melanotransferrin 0.0152214
ATP5MC1 ATP synthase membrane subunit c locus 1 0.0151905
BRCA1 breast cancer 1, early onset 0.0151357
DYNC2I1 dynein 2 intermediate chain 1 0.0151243
LRP6 low density lipoprotein receptor-related protein 6 0.0151014
DPP9 dipeptidyl-peptidase 9 0.0150618
CEP128 centrosomal protein 128kDa 0.0150458
CRK v-crk avian sarcoma virus CT10 oncogene homolog 0.0150284
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0150259
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0150105
TRIP11 thyroid hormone receptor interactor 11 0.0149409
DGAT1 diacylglycerol O-acyltransferase 1 0.0149377
WASF2 WAS protein family, member 2 0.0149347
PEAK1 pseudopodium-enriched atypical kinase 1 0.0149256
LTBP1 latent transforming growth factor beta binding protein 1 0.0148921
TPM2 tropomyosin 2 (beta) 0.0148835
GOLT1A golgi transport 1A 0.0148809
LAMP2 lysosomal-associated membrane protein 2 0.0148739
ICE1 interactor of little elongation complex ELL subunit 1 0.0148725
RBBP8 retinoblastoma binding protein 8 0.0148717
GOLM2 golgi membrane protein 2 0.0148511
HM13 histocompatibility (minor) 13 0.014849
LARP1 La ribonucleoprotein domain family, member 1 0.0148486
RPS6 ribosomal protein S6 0.0148392
RPS27 ribosomal protein S27 0.0148208
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G 0.0147929
TUBGCP2 tubulin, gamma complex associated protein 2 0.0147724
DHCR24 24-dehydrocholesterol reductase 0.0147531
CCAR1 cell division cycle and apoptosis regulator 1 0.0147511
CLCC1 chloride channel CLIC-like 1 0.0147114
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.0146321
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) 0.0146234
PCLAF PCNA clamp associated factor 0.014612
TUBB tubulin, beta class I 0.0145119
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) 0.0145062
ATP5MC3 ATP synthase membrane subunit c locus 3 0.0144739
REEP4 receptor accessory protein 4 0.0144405
TMTC3 transmembrane and tetratricopeptide repeat containing 3 0.0144199
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14 0.0143892
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 0.0143832
LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.014367
RANBP17 RAN binding protein 17 0.0143549
SELENOI selenoprotein I 0.0143179
HSPA14 heat shock 70kDa protein 14 0.0143029
SIGMAR1 sigma non-opioid intracellular receptor 1 0.0142905
TMEM109 transmembrane protein 109 0.0142872
MYO5A myosin VA (heavy chain 12, myoxin) 0.0142724
ATRAID all-trans retinoic acid-induced differentiation factor 0.0141821
SLC39A7 solute carrier family 39 (zinc transporter), member 7 0.0141459
HACD2 3-hydroxyacyl-CoA dehydratase 2 0.0141359
RPS20 ribosomal protein S20 0.0141036
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 0.0140993
SLC31A1 solute carrier family 31 (copper transporter), member 1 0.0140458
CENPP centromere protein P 0.0140165
CCT7 chaperonin containing TCP1, subunit 7 (eta) 0.0139991
ALCAM activated leukocyte cell adhesion molecule 0.0139981
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 0.0139383
LONP1 lon peptidase 1, mitochondrial 0.0139267
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.0138944
SKAP2 src kinase associated phosphoprotein 2 0.0138717
CNIH1 cornichon family AMPA receptor auxiliary protein 1 0.0138573
PDE1A phosphodiesterase 1A, calmodulin-dependent 0.0138006
AP2A2 adaptor-related protein complex 2, alpha 2 subunit 0.0137798
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.0137773
TM7SF3 transmembrane 7 superfamily member 3 0.0137491
ZSWIM6 zinc finger, SWIM-type containing 6 0.0137441
OSBP oxysterol binding protein 0.0137405
BRD3 bromodomain containing 3 0.0137156
PCSK7 proprotein convertase subtilisin/kexin type 7 0.0136994
WDR45 WD repeat domain 45 0.0136929
HMGA1 high mobility group AT-hook 1 0.0136827
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.0136671
PRDX4 peroxiredoxin 4 0.0136465
KIF5B kinesin family member 5B 0.013609
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa 0.0135979
SQLE squalene epoxidase 0.0135911
DEPDC1B DEP domain containing 1B 0.013568
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2 0.0135672
HSF1 heat shock transcription factor 1 0.0135519
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.0135162
PCDHB16 protocadherin beta 16 0.0134959
NIN ninein (GSK3B interacting protein) 0.0134859
RPL31 ribosomal protein L31 0.0134594
F11R F11 receptor 0.0134545
DHCR7 7-dehydrocholesterol reductase 0.0134504
NUDT5 nudix (nucleoside diphosphate linked moiety X)-type motif 5 0.013447
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 0.0134457
NARS1 asparaginyl-tRNA synthetase 1 0.0134282
MARK2 MAP/microtubule affinity-regulating kinase 2 0.0134156
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.013379
STIM1 stromal interaction molecule 1 0.0133725
TTLL10 tubulin tyrosine ligase-like family member 10 0.0133686
TIPRL TOR signaling pathway regulator 0.0133378
IDH3B isocitrate dehydrogenase 3 (NAD+) beta 0.0133376
TPGS1 tubulin polyglutamylase complex subunit 1 0.0133349
VRK2 vaccinia related kinase 2 0.0132753
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0132625
NECTIN2 nectin cell adhesion molecule 2 0.013223
FOXRED1 FAD-dependent oxidoreductase domain containing 1 0.013219
ATXN2 ataxin 2 0.0131909
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0131736
VMP1 vacuole membrane protein 1 0.0131391
EMP3 epithelial membrane protein 3 0.0131305
PRRC2B proline-rich coiled-coil 2B 0.0131258
MRPL13 mitochondrial ribosomal protein L13 0.0131034
ELOVL6 ELOVL fatty acid elongase 6 0.013095
MAP2K1 mitogen-activated protein kinase kinase 1 0.0130928
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0130918
GSK3A glycogen synthase kinase 3 alpha 0.0130751
TM9SF3 transmembrane 9 superfamily member 3 0.0130646
YBX3 Y box binding protein 3 0.0130597
PVR poliovirus receptor 0.0130537
MTDH metadherin 0.0130313
LMAN2 lectin, mannose-binding 2 0.0130209
MRPS18B mitochondrial ribosomal protein S18B 0.013015
UBE2Z ubiquitin-conjugating enzyme E2Z 0.0130055
PBK PDZ binding kinase 0.012972
CD24 CD24 molecule 0.0129565
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 0.0129537
SUMF2 sulfatase modifying factor 2 0.0129531
BCAT2 branched chain amino-acid transaminase 2, mitochondrial 0.0129521
INO80 INO80 complex subunit 0.0129514
RPL34 ribosomal protein L34 0.0129469
TRIM56 tripartite motif containing 56 0.0129304
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 0.0129206
ACLY ATP citrate lyase 0.0129007
SRSF3 serine/arginine-rich splicing factor 3 0.0128677
TMEM43 transmembrane protein 43 0.0128416
PIGL phosphatidylinositol glycan anchor biosynthesis, class L 0.0128379
EMC10 ER membrane protein complex subunit 10 0.0128213
VDAC2 voltage-dependent anion channel 2 0.0128192
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0128126
RAB21 RAB21, member RAS oncogene family 0.0128091
SLC35F6 solute carrier family 35, member F6 0.0128008
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) 0.0127973
F2R coagulation factor II (thrombin) receptor 0.0127963
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 0.012758
CSNK1A1 casein kinase 1, alpha 1 0.0127403
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0127268
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.0127079
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 0.012695
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 0.0126942
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 0.0126918
BCCIP BRCA2 and CDKN1A interacting protein 0.0126815
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.0126433
TRIM16 tripartite motif containing 16 0.0126364
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0126215
ZFAND5 zinc finger, AN1-type domain 5 0.0126044
ILF3 interleukin enhancer binding factor 3, 90kDa 0.0125806
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0125796
JMJD8 jumonji domain containing 8 0.0125738
GRN granulin 0.0125448
ANAPC16 anaphase promoting complex subunit 16 0.0125337
ATL2 atlastin GTPase 2 0.0125304
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.0125225
AP2S1 adaptor-related protein complex 2, sigma 1 subunit 0.0125055
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0124688
ABLIM1 actin binding LIM protein 1 0.0124281
DLG1 discs, large homolog 1 (Drosophila) 0.0124276
RAB15 RAB15, member RAS oncogene family 0.0124079
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.012371
EIF3I eukaryotic translation initiation factor 3, subunit I 0.0123414
TLK1 tousled-like kinase 1 0.0123167
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae) 0.0123159
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 0.0122866
ZNHIT1 zinc finger, HIT-type containing 1 0.0122801
RNF187 ring finger protein 187 0.0122611
MECP2 methyl CpG binding protein 2 0.0122588
POMT2 protein-O-mannosyltransferase 2 0.01225
FBXO36 F-box protein 36 0.0122498
MARCHF5 membrane associated ring-CH-type finger 5 0.0122163
NUDC nudC nuclear distribution protein 0.0121943
SCARB1 scavenger receptor class B, member 1 0.0121826
PUM3 pumilio RNA binding family member 3 0.0121804
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0121634
HSPH1 heat shock 105kDa/110kDa protein 1 0.0121573
PA2G4 proliferation-associated 2G4, 38kDa 0.012141
CD109 CD109 molecule 0.0121301
EIF5B eukaryotic translation initiation factor 5B 0.0121282
ERGIC2 ERGIC and golgi 2 0.0121076
CEP83 centrosomal protein 83kDa 0.0120897
PACS1 phosphofurin acidic cluster sorting protein 1 0.0120832
SPAG1 sperm associated antigen 1 0.0120522
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 0.0120324
BRD2 bromodomain containing 2 0.0120272
UGP2 UDP-glucose pyrophosphorylase 2 0.0120195
SEM1 SEM1 26S proteasome subunit 0.0120095
RNASEK ribonuclease, RNase K 0.0120055
HACL2 2-hydroxyacyl-CoA lyase 2 0.0120027
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) 0.0120024
VCP valosin containing protein 0.0119998
MLKL mixed lineage kinase domain-like 0.0119798
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0119626
ITPRIPL2 inositol 1,4,5-trisphosphate receptor interacting protein-like 2 0.01194
ARHGAP29 Rho GTPase activating protein 29 0.0119399
GGCX gamma-glutamyl carboxylase 0.0119033
ATP5F1B ATP synthase F1 subunit beta 0.0119014
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0118606
KIF15 kinesin family member 15 0.011859
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase 0.0118442
PDCD6IP programmed cell death 6 interacting protein 0.0118347
TMC7 transmembrane channel-like 7 0.011826
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 0.0118127
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0118065
SSR4 signal sequence receptor, delta 0.0118015

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.152513
NRG1 neuregulin 1 -0.0946943
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0944514
WWOX WW domain containing oxidoreductase -0.0820953
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0761135
DOCK5 dedicator of cytokinesis 5 -0.0757143
PSD3 pleckstrin and Sec7 domain containing 3 -0.0745819
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 -0.0701945
MED13L mediator complex subunit 13-like -0.0699583
CMIP c-Maf inducing protein -0.067399
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0649588
CUX1 cut-like homeobox 1 -0.0605893
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -0.0602988
PDE10A phosphodiesterase 10A -0.0598163
ANXA2 annexin A2 -0.0576424
BIRC6 baculoviral IAP repeat containing 6 -0.055939
EHBP1 EH domain binding protein 1 -0.0554848
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.053424
PTK2 protein tyrosine kinase 2 -0.0524689
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0520213
KRT81 keratin 81, type II -0.0508535
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.0505963
JMJD1C jumonji domain containing 1C -0.0505921
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0491262
TXNRD1 thioredoxin reductase 1 -0.0488303
EML4 echinoderm microtubule associated protein like 4 -0.0486802
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0464695
DENND5B DENN/MADD domain containing 5B -0.045651
THSD7A thrombospondin, type I, domain containing 7A -0.0455926
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0454776
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0446201
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0443194
BABAM2 BRISC and BRCA1 A complex member 2 -0.0436948
DAPK1 death-associated protein kinase 1 -0.0436059
FAM107B family with sequence similarity 107, member B -0.0422732
TTC28 tetratricopeptide repeat domain 28 -0.0421309
MYO1E myosin IE -0.0418763
RORA RAR-related orphan receptor A -0.0408672
FAF1 Fas (TNFRSF6) associated factor 1 -0.04049
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0393429
RBPMS RNA binding protein with multiple splicing -0.0386691
BICC1 BicC family RNA binding protein 1 -0.0385186
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.038507
FOXP1 forkhead box P1 -0.0384388
ZNF609 zinc finger protein 609 -0.038292
ETV6 ets variant 6 -0.0379331
STX8 syntaxin 8 -0.0378048
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0372368
SEPTIN6 septin 6 -0.0369497
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0368426
OSBPL10 oxysterol binding protein-like 10 -0.036306
TCF12 transcription factor 12 -0.0361563
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.035702
SLC35F3 solute carrier family 35, member F3 -0.0356928
ARHGAP26 Rho GTPase activating protein 26 -0.0353282
PDE8A phosphodiesterase 8A -0.0352956
FBXL17 F-box and leucine-rich repeat protein 17 -0.0349326
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -0.0348279
TUBGCP5 tubulin, gamma complex associated protein 5 -0.033659
MYO10 myosin X -0.0336277
SETD5 SET domain containing 5 -0.0332167
PAWR PRKC, apoptosis, WT1, regulator -0.0331556
SEC11A SEC11 homolog A (S. cerevisiae) -0.0329799
SIK3 SIK family kinase 3 -0.0328505
TNPO1 transportin 1 -0.0326951
ZFAND3 zinc finger, AN1-type domain 3 -0.032436
PARD3 par-3 family cell polarity regulator -0.032304
SBF2 SET binding factor 2 -0.0321968
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0321061
WWC1 WW and C2 domain containing 1 -0.0317789
BMPR1B bone morphogenetic protein receptor, type IB -0.0315252
MTUS1 microtubule associated tumor suppressor 1 -0.0313592
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0312996
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0311767
KIF13A kinesin family member 13A -0.0308092
ENSA endosulfine alpha -0.030734
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0305198
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0303788
FHIT fragile histidine triad -0.0301265
LUC7L LUC7-like (S. cerevisiae) -0.0298932
KIF13B kinesin family member 13B -0.0298345
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) -0.0297479
RRAS2 related RAS viral (r-ras) oncogene homolog 2 -0.0297106
TAOK3 TAO kinase 3 -0.029548
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) -0.0294241
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) -0.0293173
EXOC6B exocyst complex component 6B -0.029285
METTL16 methyltransferase like 16 -0.0291562
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0291063
ARID1B AT rich interactive domain 1B (SWI1-like) -0.028925
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0288874
CERS6 ceramide synthase 6 -0.0288705
TBC1D22A TBC1 domain family, member 22A -0.0288657
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0287732
SON SON DNA binding protein -0.0286873
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0285181
PBX1 pre-B-cell leukemia homeobox 1 -0.0282385
TMCC1 transmembrane and coiled-coil domain family 1 -0.0282358
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0282117
HP1BP3 heterochromatin protein 1, binding protein 3 -0.02806
CREBBP CREB binding protein -0.0277463
RABGAP1L RAB GTPase activating protein 1-like -0.027746
ITCH itchy E3 ubiquitin protein ligase -0.0275177
AK1 adenylate kinase 1 -0.0273337
SBNO1 strawberry notch homolog 1 (Drosophila) -0.0273086
RAB3B RAB3B, member RAS oncogene family -0.0271957
GPRIN3 GPRIN family member 3 -0.0271477
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 -0.0267813
SPPL2A signal peptide peptidase like 2A -0.0267155
DENND5A DENN/MADD domain containing 5A -0.0267105
CAPZB capping protein (actin filament) muscle Z-line, beta -0.0266251
NCOA1 nuclear receptor coactivator 1 -0.0265789
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) -0.0264903
RPL18 ribosomal protein L18 -0.0264038
MYOF myoferlin -0.0262783
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -0.0261269
AHCYL2 adenosylhomocysteinase-like 2 -0.0260827
VCAN versican -0.0260142
ARHGAP32 Rho GTPase activating protein 32 -0.0258079
GLG1 golgi glycoprotein 1 -0.0257721
RIOK3 RIO kinase 3 -0.0257652
VCL vinculin -0.025579
ATXN3 ataxin 3 -0.0255785
KDM2A lysine (K)-specific demethylase 2A -0.0255505
RBM6 RNA binding motif protein 6 -0.0255254
MYO1D myosin ID -0.0253712
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 -0.0253473
LONP2 lon peptidase 2, peroxisomal -0.025112
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0251059
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0249823
SPG11 spastic paraplegia 11 (autosomal recessive) -0.0249516
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0249209
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -0.0248931
AKAP13 A kinase (PRKA) anchor protein 13 -0.0248803
GPC6 glypican 6 -0.0248588
ANKRD11 ankyrin repeat domain 11 -0.0248401
SCAPER S-phase cyclin A-associated protein in the ER -0.0248047
WWTR1 WW domain containing transcription regulator 1 -0.024743
SKIL SKI-like proto-oncogene -0.0247388
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0245777
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0245118
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 -0.0242481
FCGBP Fc fragment of IgG binding protein -0.0240382
HIP1 huntingtin interacting protein 1 -0.0239381
WAC WW domain containing adaptor with coiled-coil -0.0238261
CAPN2 calpain 2, (m/II) large subunit -0.0236627
AFAP1 actin filament associated protein 1 -0.0236574
PPP4R1 protein phosphatase 4, regulatory subunit 1 -0.0236342
TFF1 trefoil factor 1 -0.0235246
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0235018
YARS1 tyrosyl-tRNA synthetase 1 -0.0234399
MLPH melanophilin -0.0234205
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0233955
USP3 ubiquitin specific peptidase 3 -0.0233879
TMEM65 transmembrane protein 65 -0.0233518
NEBL nebulette -0.0233005
TMSB10 thymosin beta 10 -0.023169
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0231624
ZNF644 zinc finger protein 644 -0.0230612
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.023052
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0228032
ZBTB20 zinc finger and BTB domain containing 20 -0.0227754
VEZT vezatin, adherens junctions transmembrane protein -0.0227532
THSD4 thrombospondin, type I, domain containing 4 -0.022701
PLD3 phospholipase D family, member 3 -0.0226342
PTCD3 pentatricopeptide repeat domain 3 -0.0226136
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0225892
NT5DC1 5'-nucleotidase domain containing 1 -0.0225613
PALLD palladin, cytoskeletal associated protein -0.0225352
PHACTR4 phosphatase and actin regulator 4 -0.0223313
PICALM phosphatidylinositol binding clathrin assembly protein -0.0223038
AMBRA1 autophagy/beclin-1 regulator 1 -0.0222075
USP53 ubiquitin specific peptidase 53 -0.0222035
PTPRM protein tyrosine phosphatase, receptor type, M -0.022089
ADAM10 ADAM metallopeptidase domain 10 -0.0218475
EML2 echinoderm microtubule associated protein like 2 -0.0217753
PTBP3 polypyrimidine tract binding protein 3 -0.0217614
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0216565
KAT6A K(lysine) acetyltransferase 6A -0.0214799
CDK13 cyclin-dependent kinase 13 -0.0214229
CP ceruloplasmin (ferroxidase) -0.0214177
ADGRG6 adhesion G protein-coupled receptor G6 -0.0212944
ECPAS Ecm29 proteasome adaptor and scaffold -0.0212879
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0212499
AFG2A AFG2 AAA ATPase homolog A -0.021248
MAP3K3 mitogen-activated protein kinase kinase kinase 3 -0.0212248
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0212034
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0211639
KMT5B lysine methyltransferase 5B -0.0211492
SRPK2 SRSF protein kinase 2 -0.0211481
FOXK2 forkhead box K2 -0.0210712
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0209878
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) -0.0209805
CAMKMT calmodulin-lysine N-methyltransferase -0.0209763
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0209596
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 -0.0209591
UBP1 upstream binding protein 1 (LBP-1a) -0.020911
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.020823
LMBR1 limb development membrane protein 1 -0.0207539
UTP4 UTP4 small subunit processome component -0.0207354
ATXN1 ataxin 1 -0.0206763
PPARG peroxisome proliferator-activated receptor gamma -0.0206509
RNF149 ring finger protein 149 -0.0206363
GLS2 glutaminase 2 (liver, mitochondrial) -0.0206036
NF1 neurofibromin 1 -0.0205944
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 -0.0205891
TNS3 tensin 3 -0.0205148
FCHSD2 FCH and double SH3 domains 2 -0.0204843
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 -0.020482
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) -0.0204785
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 -0.0204058
NSRP1 nuclear speckle splicing regulatory protein 1 -0.0204054
SUMF1 sulfatase modifying factor 1 -0.0203971
KDM5B lysine (K)-specific demethylase 5B -0.0203846
IRS2 insulin receptor substrate 2 -0.0203456
LITAF lipopolysaccharide-induced TNF factor -0.0202325
MRPS34 mitochondrial ribosomal protein S34 -0.0201476
CPNE8 copine VIII -0.0201212
AATF apoptosis antagonizing transcription factor -0.0201023
TACC1 transforming, acidic coiled-coil containing protein 1 -0.0199928
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0198166
COG5 component of oligomeric golgi complex 5 -0.0197977
KCTD20 potassium channel tetramerization domain containing 20 -0.0197898
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0197654
ZNF148 zinc finger protein 148 -0.0195821
PTPRA protein tyrosine phosphatase, receptor type, A -0.0195718
TMOD3 tropomodulin 3 (ubiquitous) -0.0195658
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 -0.0195391
CUL3 cullin 3 -0.0195262
ATOSA atos homolog A -0.0194976
CDC27 cell division cycle 27 -0.0194843
ANXA1 annexin A1 -0.0194804
ARMC9 armadillo repeat containing 9 -0.0194782
EZR ezrin -0.0194238
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0194202
CLASP2 cytoplasmic linker associated protein 2 -0.0194063
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0193409
NFX1 nuclear transcription factor, X-box binding 1 -0.0193361
KANK1 KN motif and ankyrin repeat domains 1 -0.0193241
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0192967
RPS5 ribosomal protein S5 -0.0192507
LPCAT3 lysophosphatidylcholine acyltransferase 3 -0.0192235
BCAS3 breast carcinoma amplified sequence 3 -0.0190308
COPA coatomer protein complex, subunit alpha -0.0190239
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -0.0190013
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 -0.0189604
AQR aquarius intron-binding spliceosomal factor -0.0189553
LARP1B La ribonucleoprotein domain family, member 1B -0.018942
NSD2 nuclear receptor binding SET domain protein 2 -0.0189223
MACF1 microtubule-actin crosslinking factor 1 -0.0189049
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0188962
CCDC57 coiled-coil domain containing 57 -0.0188847
NBAS neuroblastoma amplified sequence -0.0188232
PFN1 profilin 1 -0.0187832
WDR41 WD repeat domain 41 -0.0187691
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0187667
KCMF1 potassium channel modulatory factor 1 -0.0187454
XPO1 exportin 1 -0.0186525
SMC4 structural maintenance of chromosomes 4 -0.0186374
SFSWAP splicing factor, suppressor of white-apricot family -0.0185638
NSD1 nuclear receptor binding SET domain protein 1 -0.0185355
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.018502
RPSA ribosomal protein SA -0.0184674
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0184541
TUBD1 tubulin, delta 1 -0.0184298
RABEP2 rabaptin, RAB GTPase binding effector protein 2 -0.0184135
KRT7 keratin 7, type II -0.0183781
NUMB numb homolog (Drosophila) -0.0183586
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma -0.0183534
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0183424
ARHGAP42 Rho GTPase activating protein 42 -0.0183282
RPTOR regulatory associated protein of MTOR, complex 1 -0.0182861
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) -0.0182589
FRMD3 FERM domain containing 3 -0.0182497
SLC38A1 solute carrier family 38, member 1 -0.0182473
NBEA neurobeachin -0.018238
DCAF10 DDB1 and CUL4 associated factor 10 -0.0181853
GNB5 guanine nucleotide binding protein (G protein), beta 5 -0.0181813
FUS FUS RNA binding protein -0.0181791
POLG2 polymerase (DNA directed), gamma 2, accessory subunit -0.0181366
GPATCH2L G patch domain containing 2-like -0.0181129
CHD8 chromodomain helicase DNA binding protein 8 -0.0180866
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 -0.0180788
SFPQ splicing factor proline/glutamine-rich -0.0180163
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0179603
USP25 ubiquitin specific peptidase 25 -0.0178931
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0178554
SLMAP sarcolemma associated protein -0.0178077
CDC123 cell division cycle 123 -0.0177907
DSCAML1 Down syndrome cell adhesion molecule like 1 -0.0177818
CLHC1 clathrin heavy chain linker domain containing 1 -0.0177722
RGS20 regulator of G-protein signaling 20 -0.017734
FAF2 Fas associated factor family member 2 -0.0177168
LRMDA leucine rich melanocyte differentiation associated -0.0176985
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0176857
SETD2 SET domain containing 2 -0.0176788
MYO9A myosin IXA -0.017668
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0175655
PPP1R12B protein phosphatase 1, regulatory subunit 12B -0.0174977
PM20D1 peptidase M20 domain containing 1 -0.0174969
FAM222B family with sequence similarity 222, member B -0.0174866
ZNF518A zinc finger protein 518A -0.0174155
GSR glutathione reductase -0.0173504
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 -0.0172975
MIB1 mindbomb E3 ubiquitin protein ligase 1 -0.0172691
DBF4B DBF4 zinc finger B -0.0172524
PHACTR2 phosphatase and actin regulator 2 -0.0171738
FLNA filamin A, alpha -0.0171551
ULK4 unc-51 like kinase 4 -0.017141
TGOLN2 trans-golgi network protein 2 -0.0171321
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0170968
URI1 URI1, prefoldin-like chaperone -0.0170765
DTNB dystrobrevin, beta -0.0170545
UGDH UDP-glucose 6-dehydrogenase -0.0170367
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0169936
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0169757
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0169621
GPBP1 GC-rich promoter binding protein 1 -0.016866
HDGF hepatoma-derived growth factor -0.0168653
SRSF10 serine/arginine-rich splicing factor 10 -0.0168563
KDM6A lysine (K)-specific demethylase 6A -0.0168562
AKAP12 A kinase (PRKA) anchor protein 12 -0.0168359
GPR135 G protein-coupled receptor 135 -0.0168121
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0167989
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0167413
FLNB filamin B, beta -0.0167246
SCAF11 SR-related CTD-associated factor 11 -0.0167019
NPC1 Niemann-Pick disease, type C1 -0.0166448
CTPS1 CTP synthase 1 -0.0166303
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2 -0.0166137
CNKSR3 CNKSR family member 3 -0.0165713
MISP mitotic spindle positioning -0.0165711
UBE2K ubiquitin-conjugating enzyme E2K -0.0165413
UBAP1 ubiquitin associated protein 1 -0.0165386
TCEA1 transcription elongation factor A (SII), 1 -0.0165076
ANKRD36C ankyrin repeat domain 36C -0.0164906
SF3B1 splicing factor 3b, subunit 1, 155kDa -0.0164799
P3H2 prolyl 3-hydroxylase 2 -0.0164744
PSAT1 phosphoserine aminotransferase 1 -0.0164163
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) -0.0164127
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) -0.0164122
DUSP16 dual specificity phosphatase 16 -0.0163746
UBE2O ubiquitin-conjugating enzyme E2O -0.0163564
TRAP1 TNF receptor-associated protein 1 -0.0163538
GTF2IRD1 GTF2I repeat domain containing 1 -0.0163339
PRELID2 PRELI domain containing 2 -0.0162543
GGNBP2 gametogenetin binding protein 2 -0.0162374
GSPT1 G1 to S phase transition 1 -0.0162275
MRPS35 mitochondrial ribosomal protein S35 -0.0161955
ADAM17 ADAM metallopeptidase domain 17 -0.0161764
PRPF40B PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae) -0.0161241
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0161099
USP48 ubiquitin specific peptidase 48 -0.0160559
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0160496
CHD7 chromodomain helicase DNA binding protein 7 -0.0160227
EPB41L4A erythrocyte membrane protein band 4.1 like 4A -0.0160176
RHOF ras homolog family member F (in filopodia) -0.0159973
ARB2A ARB2 cotranscriptional regulator A -0.0159746
ANKRD36 ankyrin repeat domain 36 -0.015973
LMNA lamin A/C -0.0159437
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 -0.0159149
XPO7 exportin 7 -0.0158892
PCBD2 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 -0.0158627
PHTF1 putative homeodomain transcription factor 1 -0.0158392
DGKH diacylglycerol kinase, eta -0.0158205
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0158129
ESYT2 extended synaptotagmin-like protein 2 -0.0157907
ARL17B ADP-ribosylation factor-like 17B -0.0157459
BRWD3 bromodomain and WD repeat domain containing 3 -0.0157339
SNX4 sorting nexin 4 -0.0156835
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) -0.0156643
FNBP4 formin binding protein 4 -0.0156575
ANXA4 annexin A4 -0.0156449
KLHL8 kelch-like family member 8 -0.0156358
SLC22A23 solute carrier family 22, member 23 -0.0156174
KIAA1328 KIAA1328 -0.0156003
TRNP1 TMF1-regulated nuclear protein 1 -0.0155969
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -0.015566
DNAAF9 dynein axonemal assembly factor 9 -0.0155653
HMGA2 high mobility group AT-hook 2 -0.0155175
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) -0.0154799
JARID2 jumonji, AT rich interactive domain 2 -0.0154615
ZMYM4 zinc finger, MYM-type 4 -0.0154609
PTEN phosphatase and tensin homolog -0.0154339
ADD3 adducin 3 (gamma) -0.0154272
TRIO trio Rho guanine nucleotide exchange factor -0.0153904
RARS1 arginyl-tRNA synthetase 1 -0.0153801
PDE8B phosphodiesterase 8B -0.0153589
NPTN neuroplastin -0.0153412
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0153237
RBM23 RNA binding motif protein 23 -0.0152542
TMEM230 transmembrane protein 230 -0.0152459
AHNAK AHNAK nucleoprotein -0.0152455
NR1D2 nuclear receptor subfamily 1, group D, member 2 -0.0152419
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 -0.0152245
TTC17 tetratricopeptide repeat domain 17 -0.0152154
CEP290 centrosomal protein 290kDa -0.0152003
LRRK1 leucine-rich repeat kinase 1 -0.0151936
NRIP1 nuclear receptor interacting protein 1 -0.0151874
SCFD2 sec1 family domain containing 2 -0.0151788
IPO9 importin 9 -0.0151761
NINL ninein-like -0.0151751
NCOA2 nuclear receptor coactivator 2 -0.0151564
TOP2B topoisomerase (DNA) II beta 180kDa -0.0151386
AZIN2 antizyme inhibitor 2 -0.015122
BHLHE40 basic helix-loop-helix family, member e40 -0.0151203
MKI67 marker of proliferation Ki-67 -0.0151073
SEC31A SEC31 homolog A (S. cerevisiae) -0.0150983
HELZ helicase with zinc finger -0.0150803
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 -0.0150563
SDCCAG8 serologically defined colon cancer antigen 8 -0.0150516
NOP2 NOP2 nucleolar protein -0.0150346
UBE2L3 ubiquitin-conjugating enzyme E2L 3 -0.0150052
SECISBP2L SECIS binding protein 2-like -0.0149969
MTRFR mitochondrial translation release factor in rescue -0.0149962
OPHN1 oligophrenin 1 -0.0149839
DCAKD dephospho-CoA kinase domain containing -0.0149674
RNF111 ring finger protein 111 -0.0149613
SS18 synovial sarcoma translocation, chromosome 18 -0.01496
GLI2 GLI family zinc finger 2 -0.0149465
PHF12 PHD finger protein 12 -0.0149389
SLC39A10 solute carrier family 39 (zinc transporter), member 10 -0.0149332
PCNX1 pecanex 1 -0.0149139
HNRNPF heterogeneous nuclear ribonucleoprotein F -0.0149061
CCDC138 coiled-coil domain containing 138 -0.0149025
IARS1 isoleucyl-tRNA synthetase 1 -0.0148566
FBXL20 F-box and leucine-rich repeat protein 20 -0.0148547
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) -0.0148452
RASSF3 Ras association (RalGDS/AF-6) domain family member 3 -0.014844
CHD1L chromodomain helicase DNA binding protein 1-like -0.0148392
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 -0.0148336
NRF1 nuclear respiratory factor 1 -0.0148158
MRTFA myocardin related transcription factor A -0.0148012
MACROH2A1 macroH2A.1 histone -0.0147957
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0147756
FBXO11 F-box protein 11 -0.0147653
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0147409
CENPE centromere protein E, 312kDa -0.014727
ZNF37A zinc finger protein 37A -0.0146952
RHBDD3 rhomboid domain containing 3 -0.0146842
DUSP4 dual specificity phosphatase 4 -0.0146385
OTUD4 OTU deubiquitinase 4 -0.014637
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 -0.0146262
MYO18A myosin XVIIIA -0.0145437
KMT2E lysine (K)-specific methyltransferase 2E -0.014525
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.014485
FTO fat mass and obesity associated -0.0144215
HSPA8 heat shock 70kDa protein 8 -0.0144074
FILIP1 filamin A interacting protein 1 -0.0144071
CNKSR2 connector enhancer of kinase suppressor of Ras 2 -0.0143453
GRAMD1B GRAM domain containing 1B -0.0143211
MLXIP MLX interacting protein -0.014283
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0142659
TMEM41B transmembrane protein 41B -0.0142322
PRKCE protein kinase C, epsilon -0.0142071
RHOBTB3 Rho-related BTB domain containing 3 -0.0142065
NFIB nuclear factor I/B -0.0141985
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.0141619
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0141546
SMYD3 SET and MYND domain containing 3 -0.0141456
TPGS2 tubulin polyglutamylase complex subunit 2 -0.0141232
NUMBL numb homolog (Drosophila)-like -0.0141232
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0141108
WDR12 WD repeat domain 12 -0.0140889
HSPG2 heparan sulfate proteoglycan 2 -0.014068
USP47 ubiquitin specific peptidase 47 -0.014054
FAM13B family with sequence similarity 13, member B -0.0140489
CSPP1 centrosome and spindle pole associated protein 1 -0.0140486
MTREX Mtr4 exosome RNA helicase -0.0140397
MORF4L1 mortality factor 4 like 1 -0.014039
MYO9B myosin IXB -0.0140307
CCDC91 coiled-coil domain containing 91 -0.0140193
SRFBP1 serum response factor binding protein 1 -0.0139778
KIF18A kinesin family member 18A -0.0139709
CDK5RAP1 CDK5 regulatory subunit associated protein 1 -0.0139678
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) -0.0139498
SAMD4B sterile alpha motif domain containing 4B -0.0139281
MED27 mediator complex subunit 27 -0.0138944
TNNT1 troponin T type 1 (skeletal, slow) -0.0138926
WDR59 WD repeat domain 59 -0.013892
PDE4B phosphodiesterase 4B, cAMP-specific -0.0138802
TXNDC15 thioredoxin domain containing 15 -0.0138788
TOM1L1 target of myb1 (chicken)-like 1 -0.0138117
HPCAL1 hippocalcin-like 1 -0.0138025
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.013752
TRAF3 TNF receptor-associated factor 3 -0.0137234
TGFBI transforming growth factor, beta-induced, 68kDa -0.0137183
ELOF1 elongation factor 1 homolog (S. cerevisiae) -0.013689
NONO non-POU domain containing, octamer-binding -0.013682
SLC49A4 solute carrier family 49 member 4 -0.0136701
MEGF9 multiple EGF-like-domains 9 -0.0136305
ATP9B ATPase, class II, type 9B -0.0136264
TMEM117 transmembrane protein 117 -0.01362
MEIS3 Meis homeobox 3 -0.0135722
XRN2 5'-3' exoribonuclease 2 -0.0135636
PRICKLE2 prickle homolog 2 (Drosophila) -0.0135631
RANBP10 RAN binding protein 10 -0.0135301
NUP214 nucleoporin 214kDa -0.01353
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 -0.0134897
PCED1B PC-esterase domain containing 1B -0.0134823