A549_GSK-LSD1 2HCl_100nM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description GSK-LSD1 2HCl 100nM perturbation in A549 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the A549_GSK-LSD1 2HCl_100nM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
KRT8 keratin 8, type II 0.134702
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0978321
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.0975648
NCOA3 nuclear receptor coactivator 3 0.0952575
BSG basigin (Ok blood group) 0.0938098
FTL ferritin, light polypeptide 0.0843877
SYT1 synaptotagmin I 0.0838008
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0736709
AKR1C2 aldo-keto reductase family 1, member C2 0.0707801
USP34 ubiquitin specific peptidase 34 0.0657858
PKM pyruvate kinase, muscle 0.0657275
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0622427
PDE4B phosphodiesterase 4B, cAMP-specific 0.0621497
ACTN4 actinin, alpha 4 0.0602278
GCLM glutamate-cysteine ligase, modifier subunit 0.0588229
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.057473
COL5A2 collagen, type V, alpha 2 0.056144
KRT81 keratin 81, type II 0.0550336
CALR calreticulin 0.0544623
KRT7 keratin 7, type II 0.0541851
FTH1 ferritin, heavy polypeptide 1 0.0534428
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.050861
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0503479
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0496861
CENPF centromere protein F, 350/400kDa 0.0484831
CANX calnexin 0.0483676
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0468741
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0465942
S100A10 S100 calcium binding protein A10 0.0462462
CNTN1 contactin 1 0.0453405
UBL4A ubiquitin-like 4A 0.0442722
NCAPG2 non-SMC condensin II complex, subunit G2 0.0439957
FGFR1 fibroblast growth factor receptor 1 0.0431351
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0430475
AKR1C1 aldo-keto reductase family 1, member C1 0.0420559
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0416867
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0399005
ALCAM activated leukocyte cell adhesion molecule 0.0388168
KMT2E lysine (K)-specific methyltransferase 2E 0.0381968
TUBA1B tubulin, alpha 1b 0.0379248
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.037823
VCL vinculin 0.037408
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0367813
CCDC88A coiled-coil domain containing 88A 0.0360677
RPL30 ribosomal protein L30 0.035577
AVL9 AVL9 homolog (S. cerevisiase) 0.0355576
SRPK2 SRSF protein kinase 2 0.0353961
TM7SF3 transmembrane 7 superfamily member 3 0.0351215
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.034554
DST dystonin 0.0343056
PKN2 protein kinase N2 0.0342902
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0342006
RPL8 ribosomal protein L8 0.0339932
RPS6 ribosomal protein S6 0.0337824
SLC35F3 solute carrier family 35, member F3 0.0335754
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0331852
RPLP1 ribosomal protein, large, P1 0.0331335
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0330978
DIAPH2 diaphanous-related formin 2 0.0324108
CLU clusterin 0.0319896
TPI1 triosephosphate isomerase 1 0.0318918
PHIP pleckstrin homology domain interacting protein 0.0318577
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0318472
MKI67 marker of proliferation Ki-67 0.031577
S100A4 S100 calcium binding protein A4 0.0313474
BRCA1 breast cancer 1, early onset 0.0310089
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0305545
ARPP19 cAMP-regulated phosphoprotein, 19kDa 0.0303288
AURKB aurora kinase B 0.0299109
FADS2 fatty acid desaturase 2 0.0298014
UBTF upstream binding transcription factor, RNA polymerase I 0.0296962
VIM vimentin 0.029451
ZBTB38 zinc finger and BTB domain containing 38 0.0293919
RAD51B RAD51 paralog B 0.0293353
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.0290356
CPLX2 complexin 2 0.0290165
PCNX4 pecanex 4 0.0289722
ENO1 enolase 1, (alpha) 0.028916
CMIP c-Maf inducing protein 0.0287669
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0287056
DYM dymeclin 0.0286325
SMC4 structural maintenance of chromosomes 4 0.0284375
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.0282291
TGOLN2 trans-golgi network protein 2 0.0281141
TMED8 transmembrane emp24 protein transport domain containing 8 0.0280762
RPL31 ribosomal protein L31 0.0278277
NRIP1 nuclear receptor interacting protein 1 0.0276845
NCOA2 nuclear receptor coactivator 2 0.0276501
ZSWIM6 zinc finger, SWIM-type containing 6 0.0275312
CDK6 cyclin-dependent kinase 6 0.0273816
HIPK2 homeodomain interacting protein kinase 2 0.0273323
SH3KBP1 SH3-domain kinase binding protein 1 0.0273016
CTSD cathepsin D 0.0271967
MYO18A myosin XVIIIA 0.0271857
KRT18 keratin 18, type I 0.0270546
CLDN1 claudin 1 0.027049
RSL1D1 ribosomal L1 domain containing 1 0.027023
FBXO11 F-box protein 11 0.0261064
HSPA4 heat shock 70kDa protein 4 0.0259562
XPR1 xenotropic and polytropic retrovirus receptor 1 0.0259218
TOP6BL TOP6B like initiator of meiotic double strand breaks 0.025871
RECQL RecQ helicase-like 0.0257324
NONO non-POU domain containing, octamer-binding 0.0257259
AURKAIP1 aurora kinase A interacting protein 1 0.0256781
IPO9 importin 9 0.0256624
NUP210 nucleoporin 210kDa 0.0256506
MRPL13 mitochondrial ribosomal protein L13 0.0256239
RNFT2 ring finger protein, transmembrane 2 0.0256125
BUD23 BUD23 rRNA methyltransferase and ribosome maturation factor 0.0255428
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0255356
RSF1 remodeling and spacing factor 1 0.0254903
MYO5A myosin VA (heavy chain 12, myoxin) 0.0254886
LMAN2 lectin, mannose-binding 2 0.0254646
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.0253992
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.0253135
PLD5 phospholipase D family, member 5 0.0250998
PBRM1 polybromo 1 0.0250528
CST3 cystatin C 0.0249349
LMF2 lipase maturation factor 2 0.0249022
SNX1 sorting nexin 1 0.02487
MBOAT7 membrane bound O-acyltransferase domain containing 7 0.0248493
CD151 CD151 molecule (Raph blood group) 0.0248386
AURKA aurora kinase A 0.0247948
BUB1 BUB1 mitotic checkpoint serine/threonine kinase 0.0246756
INO80 INO80 complex subunit 0.0246378
YIF1B Yip1 interacting factor homolog B (S. cerevisiae) 0.0245723
VCAN versican 0.0245279
GSTP1 glutathione S-transferase pi 1 0.0244827
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0244566
POLE polymerase (DNA directed), epsilon, catalytic subunit 0.0242121
AUP1 ancient ubiquitous protein 1 0.0241762
PKP4 plakophilin 4 0.0241316
UBXN4 UBX domain protein 4 0.024017
PDIA6 protein disulfide isomerase family A, member 6 0.0239618
RRBP1 ribosome binding protein 1 0.0238518
RPL29 ribosomal protein L29 0.0238434
CCT3 chaperonin containing TCP1, subunit 3 (gamma) 0.0237957
PSEN1 presenilin 1 0.0237219
RANBP2 RAN binding protein 2 0.0236604
SFTPA2 surfactant protein A2 0.0236263
SSR4 signal sequence receptor, delta 0.0236149
EMP3 epithelial membrane protein 3 0.0233618
MAP1B microtubule-associated protein 1B 0.0232447
RPL37 ribosomal protein L37 0.0231694
PTPRF protein tyrosine phosphatase, receptor type, F 0.0230896
WDR62 WD repeat domain 62 0.0230257
RASAL2 RAS protein activator like 2 0.022961
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.022725
KIF14 kinesin family member 14 0.0226482
LASP1 LIM and SH3 protein 1 0.0226343
SMC6 structural maintenance of chromosomes 6 0.022478
PPP6R2 protein phosphatase 6, regulatory subunit 2 0.0224251
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0223988
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0222253
MTDH metadherin 0.0221857
STK24 serine/threonine kinase 24 0.0220389
PTEN phosphatase and tensin homolog 0.0220373
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.0218366
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0217811
METTL8 methyltransferase like 8 0.0217725
PROCR protein C receptor, endothelial 0.0217142
PTMA prothymosin, alpha 0.0217056
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 0.0216607
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0216454
RPS19 ribosomal protein S19 0.0215393
AGR2 anterior gradient 2 0.0214968
SKAP2 src kinase associated phosphoprotein 2 0.021392
CKAP4 cytoskeleton-associated protein 4 0.021388
HEXA hexosaminidase A (alpha polypeptide) 0.0213074
SLC38A2 solute carrier family 38, member 2 0.0212767
CHD9 chromodomain helicase DNA binding protein 9 0.0212358
PYGB phosphorylase, glycogen; brain 0.021197
COG4 component of oligomeric golgi complex 4 0.021146
RPS29 ribosomal protein S29 0.0211448
TBC1D22A TBC1 domain family, member 22A 0.0211257
PHB1 prohibitin 1 0.0211149
RPS5 ribosomal protein S5 0.0211135
OSGIN2 oxidative stress induced growth inhibitor family member 2 0.0211036
NIPBL Nipped-B homolog (Drosophila) 0.0210688
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0210558
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0209987
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0209668
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G 0.0209573
MMS22L MMS22-like, DNA repair protein 0.0209176
ANLN anillin, actin binding protein 0.0208802
NCOR2 nuclear receptor corepressor 2 0.0208596
PANK3 pantothenate kinase 3 0.020805
ZEB1 zinc finger E-box binding homeobox 1 0.0207431
TMPO thymopoietin 0.0207234
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0206696
TM2D1 TM2 domain containing 1 0.0205981
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.020582
NCAPD2 non-SMC condensin I complex, subunit D2 0.0205211
NTS neurotensin 0.0205133
LTAP1 lipid transport auxiliary protein 1 0.0203992
CHD4 chromodomain helicase DNA binding protein 4 0.0203785
CEP89 centrosomal protein 89kDa 0.0203173
DCAF7 DDB1 and CUL4 associated factor 7 0.0202923
G6PC3 glucose 6 phosphatase, catalytic, 3 0.0202911
GGT1 gamma-glutamyltransferase 1 0.020242
MDN1 MDN1, midasin homolog (yeast) 0.0201834
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.02018
MED13 mediator complex subunit 13 0.0201083
KIF4A kinesin family member 4A 0.0200703
BCAS3 breast carcinoma amplified sequence 3 0.0200341
CLTC clathrin, heavy chain (Hc) 0.0200334
RIC1 RAB6A GEF complex partner 1 0.0200133
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0199696
MBD4 methyl-CpG binding domain protein 4 0.0199688
HTATSF1 HIV-1 Tat specific factor 1 0.019928
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0198815
POLR1A polymerase (RNA) I polypeptide A, 194kDa 0.019859
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0198564
PBX1 pre-B-cell leukemia homeobox 1 0.0198142
PRELID1 PRELI domain containing 1 0.0197851
TNPO2 transportin 2 0.0197435
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 0.0197181
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0196859
WIPF2 WAS/WASL interacting protein family, member 2 0.0196312
HP1BP3 heterochromatin protein 1, binding protein 3 0.0196238
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0196134
KIF18A kinesin family member 18A 0.0195823
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.0194288
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0193628
ARHGAP11B Rho GTPase activating protein 11B 0.0193503
NACA nascent polypeptide-associated complex alpha subunit 0.0193406
SLCO3A1 solute carrier organic anion transporter family, member 3A1 0.019333
RTN3 reticulon 3 0.0192677
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0192667
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0192554
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.0192538
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0192502
GPATCH2 G patch domain containing 2 0.0192127
RPL23A ribosomal protein L23a 0.0192058
H1-3 H1.3 linker histone, cluster member 0.0191744
CYBC1 cytochrome b-245 chaperone 1 0.0191142
VKORC1L1 vitamin K epoxide reductase complex, subunit 1-like 1 0.019112
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) 0.0190993
NFX1 nuclear transcription factor, X-box binding 1 0.0190543
RFX7 regulatory factor X, 7 0.0189457
CCND1 cyclin D1 0.0189339
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 0.0188709
SLC38A1 solute carrier family 38, member 1 0.0188706
NAP1L1 nucleosome assembly protein 1-like 1 0.0188273
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0187796
RPS23 ribosomal protein S23 0.0187491
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 0.018719
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0186647
GAB2 GRB2-associated binding protein 2 0.0186192
CCNJL cyclin J-like 0.0185653
ZRANB3 zinc finger, RAN-binding domain containing 3 0.01854
PHF20 PHD finger protein 20 0.0185319
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta 0.0184682
SFMBT2 Scm-like with four mbt domains 2 0.018417
WDR75 WD repeat domain 75 0.0183515
CEMIP cell migration inducing protein, hyaluronan binding 0.018344
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.0183098
NIPSNAP1 nipsnap homolog 1 (C. elegans) 0.0182777
KIAA1549 KIAA1549 0.0182503
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0182454
KCTD1 potassium channel tetramerization domain containing 1 0.0182392
SP3 Sp3 transcription factor 0.0181887
MACROD2 MACRO domain containing 2 0.0181771
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 0.0181118
STXBP4 syntaxin binding protein 4 0.0180947
POLR1B polymerase (RNA) I polypeptide B, 128kDa 0.0180337
CBX5 chromobox homolog 5 0.0179985
IL17RA interleukin 17 receptor A 0.017977
ANXA4 annexin A4 0.0179723
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) 0.0179377
CEP290 centrosomal protein 290kDa 0.0178814
CENPA centromere protein A 0.0178757
AAK1 AP2 associated kinase 1 0.0178717
ANKRD17 ankyrin repeat domain 17 0.0178315
NFIB nuclear factor I/B 0.0178286
IER3 immediate early response 3 0.0178199
UBE2S ubiquitin-conjugating enzyme E2S 0.0177679
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0177661
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.0177239
MMP7 matrix metallopeptidase 7 0.017712
STAU2 staufen double-stranded RNA binding protein 2 0.0177019
SFPQ splicing factor proline/glutamine-rich 0.0176803
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0176565
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0176346
C2CD5 C2 calcium-dependent domain containing 5 0.0176339
PRDX1 peroxiredoxin 1 0.0176331
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 0.0176064
CCT2 chaperonin containing TCP1, subunit 2 (beta) 0.0175953
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0175654
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0175554
FLNA filamin A, alpha 0.0175307
PRSS23 protease, serine, 23 0.0175184
CCAR1 cell division cycle and apoptosis regulator 1 0.0175127
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 0.0174615
ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) 0.017452
BAIAP2L1 BAI1-associated protein 2-like 1 0.0174391
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.0173981
MUSK muscle, skeletal, receptor tyrosine kinase 0.017367
XRRA1 X-ray radiation resistance associated 1 0.017358
RRP1B ribosomal RNA processing 1B 0.0173534
BICC1 BicC family RNA binding protein 1 0.0173503
ZNF146 zinc finger protein 146 0.0173098
RRP36 ribosomal RNA processing 36 homolog (S. cerevisiae) 0.0172759
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 0.0171523
MSH2 mutS homolog 2 0.0171497
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0171116
CDPF1 cysteine-rich, DPF motif domain containing 1 0.0171061
KPNA6 karyopherin alpha 6 (importin alpha 7) 0.0170928
MORC4 MORC family CW-type zinc finger 4 0.0170356
CASD1 CAS1 domain containing 1 0.017008
UTRN utrophin 0.0168934
EIF6 eukaryotic translation initiation factor 6 0.0168515
U2SURP U2 snRNP-associated SURP domain containing 0.0168496
FLII flightless I homolog (Drosophila) 0.0168327
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0167991
GON4L gon-4-like (C. elegans) 0.0167901
CACNG8 calcium channel, voltage-dependent, gamma subunit 8 0.016769
RBL1 retinoblastoma-like 1 0.0167473
PFN1 profilin 1 0.0167463
WDSUB1 WD repeat, sterile alpha motif and U-box domain containing 1 0.0167104
RBM26 RNA binding motif protein 26 0.0166814
NR2C1 nuclear receptor subfamily 2, group C, member 1 0.0166498
ZC3HC1 zinc finger, C3HC-type containing 1 0.0166398
DDB2 damage-specific DNA binding protein 2, 48kDa 0.0166382
NGLY1 N-glycanase 1 0.0166105
SIMC1 SUMO-interacting motifs containing 1 0.0165527
FANCD2 Fanconi anemia, complementation group D2 0.0164805
SCAPER S-phase cyclin A-associated protein in the ER 0.0164789
KIF18B kinesin family member 18B 0.0164538
SSBP1 single-stranded DNA binding protein 1, mitochondrial 0.0164387
SAMD5 sterile alpha motif domain containing 5 0.0164049
FRS2 fibroblast growth factor receptor substrate 2 0.0163694
GFOD2 glucose-fructose oxidoreductase domain containing 2 0.0163612
GDE1 glycerophosphodiester phosphodiesterase 1 0.016297
JMJD8 jumonji domain containing 8 0.0162735
POLK polymerase (DNA directed) kappa 0.0162705
SPART spartin 0.0162617
NAT8 N-acetyltransferase 8 (GCN5-related, putative) 0.0162518
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa 0.0162473
NMT2 N-myristoyltransferase 2 0.0162382
CYB561A3 cytochrome b561 family, member A3 0.0161906
FTO fat mass and obesity associated 0.0161852
RHOBTB1 Rho-related BTB domain containing 1 0.0161581
DMWD dystrophia myotonica, WD repeat containing 0.0160663
ICE2 interactor of little elongation complex ELL subunit 2 0.0160511
FBXO17 F-box protein 17 0.0160486
ATXN7 ataxin 7 0.0160373
BRD3 bromodomain containing 3 0.0160369
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0159943
RBM25 RNA binding motif protein 25 0.0159574
SYNGR2 synaptogyrin 2 0.0159187
SYNJ2BP synaptojanin 2 binding protein 0.0158659
GRB2 growth factor receptor-bound protein 2 0.0158515
FRK fyn-related Src family tyrosine kinase 0.0158334
RPS2 ribosomal protein S2 0.0158223
EMP2 epithelial membrane protein 2 0.0158003
PDIA4 protein disulfide isomerase family A, member 4 0.0157895
NOTCH3 notch 3 0.0157835
SAE1 SUMO1 activating enzyme subunit 1 0.0157813
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 0.0157754
SEC23B Sec23 homolog B (S. cerevisiae) 0.0157747
RRM1 ribonucleotide reductase M1 0.0157737
TMEM41B transmembrane protein 41B 0.0157565
MAP3K10 mitogen-activated protein kinase kinase kinase 10 0.015734
GNAS GNAS complex locus 0.0156935
ZNF451 zinc finger protein 451 0.0156497
HMOX1 heme oxygenase 1 0.0156477
KLF13 Kruppel-like factor 13 0.015625
OAZ1 ornithine decarboxylase antizyme 1 0.0155682
TSC22D1 TSC22 domain family, member 1 0.015565
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.015549
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 0.0155412
DMAC2L distal membrane arm assembly component 2 like 0.0155248
KTN1 kinectin 1 (kinesin receptor) 0.015517
RPL3 ribosomal protein L3 0.0154889
UBE2G2 ubiquitin-conjugating enzyme E2G 2 0.0154588
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0154275
PTGR1 prostaglandin reductase 1 0.0154058
DCTN4 dynactin 4 (p62) 0.0153987
TMED7 transmembrane emp24 protein transport domain containing 7 0.0152967
TBCD tubulin folding cofactor D 0.0152864
MARCHF6 membrane associated ring-CH-type finger 6 0.0152823
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 0.0152595
ACSF2 acyl-CoA synthetase family member 2 0.0152202
KIAA0753 KIAA0753 0.015216
PLPP1 phospholipid phosphatase 1 0.0152122
ASCC1 activating signal cointegrator 1 complex subunit 1 0.0152067
TMEM165 transmembrane protein 165 0.015194
MCM4 minichromosome maintenance complex component 4 0.015191
SEPTIN11 septin 11 0.0151832
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 0.0151727
BFAR bifunctional apoptosis regulator 0.0151726
PLD3 phospholipase D family, member 3 0.0151683
IPO7 importin 7 0.0151552
RPN2 ribophorin II 0.0151463
IL1R1 interleukin 1 receptor, type I 0.0151158
BIRC6 baculoviral IAP repeat containing 6 0.0150993
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0150971
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0150786
BRD1 bromodomain containing 1 0.0150771
PTAR1 protein prenyltransferase alpha subunit repeat containing 1 0.0150397
ARHGAP21 Rho GTPase activating protein 21 0.0150209
RAB2A RAB2A, member RAS oncogene family 0.014963
ABHD2 abhydrolase domain containing 2 0.0149506
PRPF4B pre-mRNA processing factor 4B 0.0148736
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) 0.0148699
TOMM70 translocase of outer mitochondrial membrane 70 0.0148494
CLASRP CLK4-associating serine/arginine rich protein 0.0148326
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0148064
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0147601
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0147241
CLIC4 chloride intracellular channel 4 0.0147041
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 0.0146643
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0146543
PRKCSH protein kinase C substrate 80K-H 0.0146505
SBF2 SET binding factor 2 0.0146049
LIN54 lin-54 DREAM MuvB core complex component 0.0145977
KIF2C kinesin family member 2C 0.0145921
IFT74 intraflagellar transport 74 0.0145835
CDK5RAP1 CDK5 regulatory subunit associated protein 1 0.0145416
CHURC1-FNTB CHURC1-FNTB readthrough 0.0145297
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0145297
TBXAS1 thromboxane A synthase 1 (platelet) 0.0145292
FXYD5 FXYD domain containing ion transport regulator 5 0.014522
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.014509
SNAP25 synaptosomal-associated protein, 25kDa 0.0145058
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0144921
KPNA3 karyopherin alpha 3 (importin alpha 4) 0.014479
SH2D3A SH2 domain containing 3A 0.0144763
GPR137B G protein-coupled receptor 137B 0.0144635
FANCA Fanconi anemia, complementation group A 0.0144151
EXO1 exonuclease 1 0.0144034
USP53 ubiquitin specific peptidase 53 0.0143976
TCF25 transcription factor 25 (basic helix-loop-helix) 0.0143637
MRPL41 mitochondrial ribosomal protein L41 0.0143462
RSRC2 arginine/serine-rich coiled-coil 2 0.0143117
GLG1 golgi glycoprotein 1 0.0143029
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 0.0143017
DCTN1 dynactin 1 0.0142878
MIDN midnolin 0.0142853
NUCB1 nucleobindin 1 0.0142656
SAR1A secretion associated, Ras related GTPase 1A 0.0142578
UQCRC2 ubiquinol-cytochrome c reductase core protein II 0.0142077
ALDH1L2 aldehyde dehydrogenase 1 family, member L2 0.0141857
DAD1 defender against cell death 1 0.0141445
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 0.0141215
GRAMD1B GRAM domain containing 1B 0.0140969
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 0.0140567
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0140385
TFPI2 tissue factor pathway inhibitor 2 0.0140222
PHRF1 PHD and ring finger domains 1 0.0140221
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.014016
ELOVL5 ELOVL fatty acid elongase 5 0.0139827
DNM1 dynamin 1 0.0139584
NUMB numb homolog (Drosophila) 0.0139334
FBXL5 F-box and leucine-rich repeat protein 5 0.0138918
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0138884
SLFN11 schlafen family member 11 0.0138798
SRGN serglycin 0.0138712
CLOCK clock circadian regulator 0.0138487
ARMC7 armadillo repeat containing 7 0.0138453
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) 0.0138343
PARK7 parkinson protein 7 0.0138029
TPX2 TPX2, microtubule-associated 0.0137954
XYLB xylulokinase homolog (H. influenzae) 0.0137797
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.0137767
PDGFD platelet derived growth factor D 0.0137685
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 0.0137643
HIPK1 homeodomain interacting protein kinase 1 0.013764
RUFY1 RUN and FYVE domain containing 1 0.0137369
GAN gigaxonin 0.0137322
DENND1B DENN/MADD domain containing 1B 0.0137283
WWC3 WWC family member 3 0.0136784
NR2F2 nuclear receptor subfamily 2, group F, member 2 0.0136758
NLRP2B NLR family pyrin domain containing 2B 0.0136554
VPS29 vacuolar protein sorting 29 homolog (S. cerevisiae) 0.0136347
HERPUD2 HERPUD family member 2 0.0136222
DNMBP dynamin binding protein 0.0136214
TBC1D4 TBC1 domain family, member 4 0.0136049
TXLNA taxilin alpha 0.0135848
PBX3 pre-B-cell leukemia homeobox 3 0.0135791
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.0135754
SLMAP sarcolemma associated protein 0.0135644
TUSC3 tumor suppressor candidate 3 0.0135599
SUN2 Sad1 and UNC84 domain containing 2 0.0135432
EIPR1 EARP complex and GARP complex interacting protein 1 0.0134854
AFF4 AF4/FMR2 family, member 4 0.0134587
ZER1 zyg-11 related, cell cycle regulator 0.013428
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa 0.0134092
INTS7 integrator complex subunit 7 0.0134037
SSR2 signal sequence receptor, beta (translocon-associated protein beta) 0.0133772
USP22 ubiquitin specific peptidase 22 0.0133683
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0133624
SPACA6 sperm acrosome associated 6 0.0133575
SENP7 SUMO1/sentrin specific peptidase 7 0.0133422
BCL2 B-cell CLL/lymphoma 2 0.0132915
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0132787
STK39 serine threonine kinase 39 0.0132691
IFT81 intraflagellar transport 81 0.0132551
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0132507

decreased expression

Symbol Name Standardized Value
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0957089
ZBTB20 zinc finger and BTB domain containing 20 -0.0921493
PCDH9 protocadherin 9 -0.0879972
DOCK5 dedicator of cytokinesis 5 -0.0870471
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0817813
FN1 fibronectin 1 -0.0787596
PARD3 par-3 family cell polarity regulator -0.0775997
NCOR1 nuclear receptor corepressor 1 -0.0725155
PDE4D phosphodiesterase 4D, cAMP-specific -0.0683724
THSD7A thrombospondin, type I, domain containing 7A -0.0640719
PTPRK protein tyrosine phosphatase, receptor type, K -0.0623583
CUX1 cut-like homeobox 1 -0.0589357
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0579471
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0561425
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.054886
SLC39A11 solute carrier family 39, member 11 -0.0520156
MCU mitochondrial calcium uniporter -0.0518287
MED13L mediator complex subunit 13-like -0.0502289
RAB10 RAB10, member RAS oncogene family -0.049885
FRMD3 FERM domain containing 3 -0.047797
METTL16 methyltransferase like 16 -0.04768
FMNL2 formin-like 2 -0.0474027
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -0.0464797
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0463978
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0458468
RBM6 RNA binding motif protein 6 -0.0452577
SMAD3 SMAD family member 3 -0.0449875
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.044751
NF1 neurofibromin 1 -0.044668
WWC1 WW and C2 domain containing 1 -0.0438412
PDE10A phosphodiesterase 10A -0.0437469
PALLD palladin, cytoskeletal associated protein -0.0432744
PDE8A phosphodiesterase 8A -0.0430394
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0425815
MYO1E myosin IE -0.0415179
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0412537
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0412528
NRG1 neuregulin 1 -0.0410047
TACC2 transforming, acidic coiled-coil containing protein 2 -0.0409824
MTUS1 microtubule associated tumor suppressor 1 -0.0396955
TRIO trio Rho guanine nucleotide exchange factor -0.0396167
TXNRD1 thioredoxin reductase 1 -0.0384933
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0384887
FCGBP Fc fragment of IgG binding protein -0.0383992
HIP1 huntingtin interacting protein 1 -0.0380167
ELMO1 engulfment and cell motility 1 -0.0379634
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0378305
CNTNAP3B contactin associated protein-like 3B -0.0376959
RAP1B RAP1B, member of RAS oncogene family -0.0376128
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0375158
LIMCH1 LIM and calponin homology domains 1 -0.0373617
FAM107B family with sequence similarity 107, member B -0.0372249
EHBP1 EH domain binding protein 1 -0.037219
ZFHX3 zinc finger homeobox 3 -0.0371027
KYNU kynureninase -0.0370724
PDXK pyridoxal (pyridoxine, vitamin B6) kinase -0.0363287
ADCY9 adenylate cyclase 9 -0.0362591
BLVRB biliverdin reductase B -0.0361061
ATXN2 ataxin 2 -0.0359793
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0359549
SEPTIN6 septin 6 -0.0357299
RAB1A RAB1A, member RAS oncogene family -0.0356816
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0354485
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.035337
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 -0.0351237
PPP1R9A protein phosphatase 1, regulatory subunit 9A -0.0350903
LARP1 La ribonucleoprotein domain family, member 1 -0.0347542
GSR glutathione reductase -0.034577
BMPR1B bone morphogenetic protein receptor, type IB -0.0343958
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0335209
ARHGAP26 Rho GTPase activating protein 26 -0.0333676
CELF1 CUGBP, Elav-like family member 1 -0.0332026
FAF1 Fas (TNFRSF6) associated factor 1 -0.0331478
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0329852
ELF2 E74-like factor 2 (ets domain transcription factor) -0.032904
TXN2 thioredoxin 2 -0.0328555
PDLIM5 PDZ and LIM domain 5 -0.0324826
ANXA2 annexin A2 -0.0322107
SGMS1 sphingomyelin synthase 1 -0.0316105
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0315883
USP32 ubiquitin specific peptidase 32 -0.0315677
STRN striatin, calmodulin binding protein -0.0311209
PARD3B par-3 family cell polarity regulator beta -0.0309816
PSD3 pleckstrin and Sec7 domain containing 3 -0.0309805
AGFG1 ArfGAP with FG repeats 1 -0.0308694
USP36 ubiquitin specific peptidase 36 -0.0308427
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 -0.0308129
MPG N-methylpurine-DNA glycosylase -0.0307777
RORA RAR-related orphan receptor A -0.0306764
SH3RF1 SH3 domain containing ring finger 1 -0.0306045
ATXN7L1 ataxin 7-like 1 -0.0304439
FOCAD focadhesin -0.0302519
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 -0.0300296
GRAMD1A GRAM domain containing 1A -0.0299186
THADA thyroid adenoma associated -0.0298107
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.02977
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.029673
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) -0.0295723
SETBP1 SET binding protein 1 -0.029479
TNRC6B trinucleotide repeat containing 6B -0.0293207
PTPRA protein tyrosine phosphatase, receptor type, A -0.0291197
PTBP3 polypyrimidine tract binding protein 3 -0.0290989
UNC13B unc-13 homolog B (C. elegans) -0.0287427
TTC28 tetratricopeptide repeat domain 28 -0.0286053
EPS8 epidermal growth factor receptor pathway substrate 8 -0.028482
ARHGAP24 Rho GTPase activating protein 24 -0.0284191
SH3D19 SH3 domain containing 19 -0.0283636
MEGF9 multiple EGF-like-domains 9 -0.0282629
LMTK2 lemur tyrosine kinase 2 -0.0282453
NT5C2 5'-nucleotidase, cytosolic II -0.0282427
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0282414
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -0.0282237
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0280699
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0279602
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0279572
ARHGAP42 Rho GTPase activating protein 42 -0.0279303
FHIT fragile histidine triad -0.0279211
KIF13A kinesin family member 13A -0.0278701
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0276807
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0275766
GPR39 G protein-coupled receptor 39 -0.0275287
TLK2 tousled-like kinase 2 -0.0275241
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 -0.0274937
ZNF638 zinc finger protein 638 -0.0273292
HOMER2 homer scaffolding protein 2 -0.0272615
MAP7 microtubule-associated protein 7 -0.0271775
MAML3 mastermind-like 3 (Drosophila) -0.0269338
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0268751
PCDHB16 protocadherin beta 16 -0.0268069
DUSP16 dual specificity phosphatase 16 -0.026633
PUS7 pseudouridylate synthase 7 (putative) -0.02661
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0265878
CAPNS1 calpain, small subunit 1 -0.0265591
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -0.0265405
CPT1A carnitine palmitoyltransferase 1A (liver) -0.0265246
TAOK3 TAO kinase 3 -0.0264459
FCHSD2 FCH and double SH3 domains 2 -0.0263614
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -0.0262485
TPM3 tropomyosin 3 -0.0262422
UBAP2 ubiquitin associated protein 2 -0.0262044
SPG11 spastic paraplegia 11 (autosomal recessive) -0.026182
ATM ATM serine/threonine kinase -0.0261685
MTCL1 microtubule crosslinking factor 1 -0.0261572
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0261465
AGO2 argonaute RISC catalytic component 2 -0.0261331
WAC WW domain containing adaptor with coiled-coil -0.0260793
ERBIN erbb2 interacting protein -0.0260073
BCL9L B-cell CLL/lymphoma 9-like -0.0260055
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -0.0258833
RPL38 ribosomal protein L38 -0.0256542
CNKSR3 CNKSR family member 3 -0.0254889
SINHCAF SIN3-HDAC complex associated factor -0.0253747
HEATR5B HEAT repeat containing 5B -0.0253485
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 -0.0252923
CLIP2 CAP-GLY domain containing linker protein 2 -0.0252661
MICU1 mitochondrial calcium uptake 1 -0.0251901
JMJD1C jumonji domain containing 1C -0.0251704
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0250028
PLCB4 phospholipase C, beta 4 -0.0249529
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0249349
FRYL FRY-like -0.0249293
KIF13B kinesin family member 13B -0.0249114
GMDS GDP-mannose 4,6-dehydratase -0.0248959
AXL AXL receptor tyrosine kinase -0.0248819
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) -0.0248505
ATL2 atlastin GTPase 2 -0.0246388
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -0.0246221
AREG amphiregulin -0.0245731
FBXW11 F-box and WD repeat domain containing 11 -0.0244724
UBE3C ubiquitin protein ligase E3C -0.0243777
ARMH3 armadillo like helical domain containing 3 -0.0242166
DICER1 dicer 1, ribonuclease type III -0.0241943
SNX14 sorting nexin 14 -0.024127
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0241166
EEIG1 estrogen-induced osteoclastogenesis regulator 1 -0.0240453
NLK nemo-like kinase -0.0239343
NINL ninein-like -0.0238963
ZNF331 zinc finger protein 331 -0.023826
ANKRD28 ankyrin repeat domain 28 -0.0237513
PPP1R13B protein phosphatase 1, regulatory subunit 13B -0.0236734
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 -0.0236661
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0236473
TRIM56 tripartite motif containing 56 -0.0235938
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0235293
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -0.0234756
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 -0.0234721
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0234702
MGA MGA, MAX dimerization protein -0.0234211
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 -0.0232456
PAWR PRKC, apoptosis, WT1, regulator -0.023242
KPNB1 karyopherin (importin) beta 1 -0.0231667
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -0.0231158
CDK19 cyclin-dependent kinase 19 -0.0230888
RC3H1 ring finger and CCCH-type domains 1 -0.0229383
TP63 tumor protein p63 -0.0229304
AGO3 argonaute RISC catalytic component 3 -0.022908
OLA1 Obg-like ATPase 1 -0.022888
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 -0.022807
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0227884
PTCD3 pentatricopeptide repeat domain 3 -0.0227437
GLE1 GLE1 RNA export mediator -0.0227205
ARID1A AT rich interactive domain 1A (SWI-like) -0.0227011
AKAP10 A kinase (PRKA) anchor protein 10 -0.0226848
FAM13A family with sequence similarity 13, member A -0.022654
FAM222B family with sequence similarity 222, member B -0.0225943
CBR4 carbonyl reductase 4 -0.0225629
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -0.0225589
KDM2A lysine (K)-specific demethylase 2A -0.0225402
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0225199
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha -0.0224268
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0223479
GTF2IRD1 GTF2I repeat domain containing 1 -0.0222953
XPO7 exportin 7 -0.0222244
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.02222
APP amyloid beta (A4) precursor protein -0.0222168
DENND4C DENN/MADD domain containing 4C -0.022209
MTFMT mitochondrial methionyl-tRNA formyltransferase -0.0221824
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0221128
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 -0.0220884
ARHGAP12 Rho GTPase activating protein 12 -0.0220786
SPAG9 sperm associated antigen 9 -0.0220739
TRIP12 thyroid hormone receptor interactor 12 -0.0220635
PHC3 polyhomeotic homolog 3 (Drosophila) -0.0220345
DNPEP aspartyl aminopeptidase -0.0220333
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) -0.0220291
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0219896
CEP192 centrosomal protein 192kDa -0.0218637
LDHB lactate dehydrogenase B -0.0218561
BOD1L1 biorientation of chromosomes in cell division 1-like 1 -0.0218091
TPR translocated promoter region, nuclear basket protein -0.0217822
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0217749
AKAP13 A kinase (PRKA) anchor protein 13 -0.0216852
HKDC1 hexokinase domain containing 1 -0.0216493
LMBR1 limb development membrane protein 1 -0.021561
OSBPL9 oxysterol binding protein-like 9 -0.0214936
RGS17 regulator of G-protein signaling 17 -0.0214766
ATXN1 ataxin 1 -0.0213646
KIFC3 kinesin family member C3 -0.0213517
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.021332
CYFIP1 cytoplasmic FMR1 interacting protein 1 -0.0213079
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast) -0.0212303
HDLBP high density lipoprotein binding protein -0.0212188
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0212111
LRMDA leucine rich melanocyte differentiation associated -0.0212035
SETD2 SET domain containing 2 -0.021098
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0210903
TJP1 tight junction protein 1 -0.0210134
FANCC Fanconi anemia, complementation group C -0.0209835
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 -0.0209737
FGA fibrinogen alpha chain -0.0209316
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -0.0209154
MYOF myoferlin -0.0209123
CUL5 cullin 5 -0.020872
MPRIP myosin phosphatase Rho interacting protein -0.0208663
ARL4C ADP-ribosylation factor-like 4C -0.0208053
TNRC6A trinucleotide repeat containing 6A -0.0207835
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.0207576
CMTM8 CKLF-like MARVEL transmembrane domain containing 8 -0.0207504
EYA4 EYA transcriptional coactivator and phosphatase 4 -0.0207078
ZCCHC8 zinc finger, CCHC domain containing 8 -0.0205646
ACIN1 apoptotic chromatin condensation inducer 1 -0.0205454
MECP2 methyl CpG binding protein 2 -0.0205412
DOCK1 dedicator of cytokinesis 1 -0.020496
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -0.020456
RAP1GAP2 RAP1 GTPase activating protein 2 -0.0203167
MGLL monoglyceride lipase -0.0202859
MFF mitochondrial fission factor -0.0202273
ELP3 elongator acetyltransferase complex subunit 3 -0.0202096
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0201734
WWTR1 WW domain containing transcription regulator 1 -0.020166
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 -0.0200565
FOXK2 forkhead box K2 -0.0200118
LRIF1 ligand dependent nuclear receptor interacting factor 1 -0.0200086
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -0.0199445
PGK1 phosphoglycerate kinase 1 -0.019939
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2 -0.0199067
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0199026
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0199008
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) -0.0198791
MAP2K5 mitogen-activated protein kinase kinase 5 -0.0198683
IRS2 insulin receptor substrate 2 -0.0198605
GNG12 guanine nucleotide binding protein (G protein), gamma 12 -0.0197942
TMEM245 transmembrane protein 245 -0.0197671
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0197626
LRRK2 leucine-rich repeat kinase 2 -0.0197135
NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 -0.0196564
PUM1 pumilio RNA-binding family member 1 -0.0196345
CLASP2 cytoplasmic linker associated protein 2 -0.0195867
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -0.0195657
RNF216 ring finger protein 216 -0.0195447
SLC45A4 solute carrier family 45, member 4 -0.0194681
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0194162
ITGB5 integrin, beta 5 -0.019401
RIN2 Ras and Rab interactor 2 -0.0193321
NUP214 nucleoporin 214kDa -0.0193171
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0192822
RBM39 RNA binding motif protein 39 -0.0192564
LARP1B La ribonucleoprotein domain family, member 1B -0.0191771
DLG1 discs, large homolog 1 (Drosophila) -0.0191609
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0189657
WDR59 WD repeat domain 59 -0.0189638
GALK2 galactokinase 2 -0.0189271
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.0188603
USP9X ubiquitin specific peptidase 9, X-linked -0.0188466
CCDC91 coiled-coil domain containing 91 -0.0187357
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0187333
ZNF33A zinc finger protein 33A -0.0187188
RNASE12 ribonuclease, RNase A family, 12 (non-active) -0.0186872
SMC5 structural maintenance of chromosomes 5 -0.0186587
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit -0.0186075
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0185917
JARID2 jumonji, AT rich interactive domain 2 -0.0185816
COIL coilin -0.0184742
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0184671
FBXL2 F-box and leucine-rich repeat protein 2 -0.0184437
WDPCP WD repeat containing planar cell polarity effector -0.0184404
TNS3 tensin 3 -0.0184369
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D -0.0184302
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa -0.0183609
CDC27 cell division cycle 27 -0.0183139
TUBGCP5 tubulin, gamma complex associated protein 5 -0.018283
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0182514
TOPBP1 topoisomerase (DNA) II binding protein 1 -0.0182269
WASF2 WAS protein family, member 2 -0.0182201
GCFC2 GC-rich sequence DNA-binding factor 2 -0.0181349
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0180661
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.018066
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0180191
PRELID2 PRELI domain containing 2 -0.0180037
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) -0.0180021
SPIDR scaffolding protein involved in DNA repair -0.0179956
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0179698
AFF1 AF4/FMR2 family, member 1 -0.017948
MLEC malectin -0.0178269
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0178163
FAM177A1 family with sequence similarity 177, member A1 -0.0178122
UBR1 ubiquitin protein ligase E3 component n-recognin 1 -0.0176584
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 -0.0175622
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -0.0175093
NPAS2 neuronal PAS domain protein 2 -0.0174621
BBX bobby sox homolog (Drosophila) -0.0174519
GATAD2B GATA zinc finger domain containing 2B -0.0174316
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type -0.0173395
PTK2 protein tyrosine kinase 2 -0.0173194
TTC7A tetratricopeptide repeat domain 7A -0.0172886
OFD1 oral-facial-digital syndrome 1 -0.0172539
EPN2 epsin 2 -0.0172503
ERBB3 erb-b2 receptor tyrosine kinase 3 -0.0172315
EPB41L5 erythrocyte membrane protein band 4.1 like 5 -0.017202
TKT transketolase -0.0171878
MAPK14 mitogen-activated protein kinase 14 -0.0171842
UIMC1 ubiquitin interaction motif containing 1 -0.0171665
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0171595
MBTPS1 membrane-bound transcription factor peptidase, site 1 -0.0170572
NAMPT nicotinamide phosphoribosyltransferase -0.0170341
RPS24 ribosomal protein S24 -0.0170198
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.016983
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0169795
DARS1 aspartyl-tRNA synthetase 1 -0.0169671
CFH complement factor H -0.0169666
RRAS2 related RAS viral (r-ras) oncogene homolog 2 -0.016949
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) -0.0169488
TUFM Tu translation elongation factor, mitochondrial -0.0169146
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0169129
MDM4 MDM4, p53 regulator -0.0168529
RABEP1 rabaptin, RAB GTPase binding effector protein 1 -0.0168446
PTGES2 prostaglandin E synthase 2 -0.0168022
PUM3 pumilio RNA binding family member 3 -0.0167986
RBBP6 retinoblastoma binding protein 6 -0.0167697
PIBF1 progesterone immunomodulatory binding factor 1 -0.0167454
NEO1 neogenin 1 -0.0167445
POLG2 polymerase (DNA directed), gamma 2, accessory subunit -0.0167158
KMT2A lysine (K)-specific methyltransferase 2A -0.0167072
TPT1 tumor protein, translationally-controlled 1 -0.0166889
CLINT1 clathrin interactor 1 -0.0166857
ARHGAP5 Rho GTPase activating protein 5 -0.0166601
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0166598
CRTC1 CREB regulated transcription coactivator 1 -0.0166446
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 -0.0165778
IGSF11 immunoglobulin superfamily, member 11 -0.0165538
CABLES1 Cdk5 and Abl enzyme substrate 1 -0.016552
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0165249
PHTF2 putative homeodomain transcription factor 2 -0.0165058
TM4SF4 transmembrane 4 L six family member 4 -0.0164888
ITSN2 intersectin 2 -0.016441
PLS1 plastin 1 -0.0164363
TUBB tubulin, beta class I -0.0164269
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -0.0164252
GSK3B glycogen synthase kinase 3 beta -0.016422
ACVR1 activin A receptor, type I -0.016407
XPO1 exportin 1 -0.0164032
PICALM phosphatidylinositol binding clathrin assembly protein -0.0163821
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0163794
C5 complement component 5 -0.0163228
NEMF nuclear export mediator factor -0.016261
GGNBP2 gametogenetin binding protein 2 -0.0162556
ZCCHC10 zinc finger, CCHC domain containing 10 -0.016238
COL4A5 collagen, type IV, alpha 5 -0.0161544
FNDC3A fibronectin type III domain containing 3A -0.0161532
GABPB1 GA binding protein transcription factor, beta subunit 1 -0.0161293
COP1 COP1 E3 ubiquitin ligase -0.016105
MARF1 meiosis regulator and mRNA stability factor 1 -0.0161024
SEC14L1 SEC14-like 1 (S. cerevisiae) -0.0160928
SDCCAG8 serologically defined colon cancer antigen 8 -0.0160869
EML2 echinoderm microtubule associated protein like 2 -0.0160749
TUBD1 tubulin, delta 1 -0.016067
GPHN gephyrin -0.0160326
GOLM1 golgi membrane protein 1 -0.0159481
DAPK1 death-associated protein kinase 1 -0.0159185
WDR20 WD repeat domain 20 -0.015917
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0159083
ACOT7 acyl-CoA thioesterase 7 -0.0158949
MBD5 methyl-CpG binding domain protein 5 -0.0158856
PCED1B PC-esterase domain containing 1B -0.0158841
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0158792
DNAAF9 dynein axonemal assembly factor 9 -0.0158599
ZMYM2 zinc finger, MYM-type 2 -0.0158505
ILKAP integrin-linked kinase-associated serine/threonine phosphatase -0.0158423
UBE2O ubiquitin-conjugating enzyme E2O -0.0158361
WDR45 WD repeat domain 45 -0.0158047
TASOR2 transcription activation suppressor family member 2 -0.0158037
CDCA2 cell division cycle associated 2 -0.0157822
ITGA6 integrin, alpha 6 -0.0157708
RSBN1L round spermatid basic protein 1-like -0.0157694
PDE8B phosphodiesterase 8B -0.0157499
SPAG7 sperm associated antigen 7 -0.0157423
ARL8B ADP-ribosylation factor-like 8B -0.0157421
SH3RF2 SH3 domain containing ring finger 2 -0.0157416
WWP1 WW domain containing E3 ubiquitin protein ligase 1 -0.0157353
NT5DC3 5'-nucleotidase domain containing 3 -0.0156903
DYNC2I1 dynein 2 intermediate chain 1 -0.0156649
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0156573
CMC2 C-x(9)-C motif containing 2 -0.0156554
KRTAP11-1 keratin associated protein 11-1 -0.015634
KIAA0232 KIAA0232 -0.0156197
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0155485
PRTG protogenin -0.015506
NPEPPS aminopeptidase puromycin sensitive -0.0154905
NUP160 nucleoporin 160kDa -0.0154863
ZBTB1 zinc finger and BTB domain containing 1 -0.0154815
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) -0.0154798
KLF5 Kruppel-like factor 5 (intestinal) -0.015474
WDR33 WD repeat domain 33 -0.0153811
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0153639
RAB31 RAB31, member RAS oncogene family -0.0153253
CP ceruloplasmin (ferroxidase) -0.0153138
INAVA innate immunity activator -0.0153101
PRC1 protein regulator of cytokinesis 1 -0.0153026
RREB1 ras responsive element binding protein 1 -0.015248
PANK2 pantothenate kinase 2 -0.0152432
PHACTR2 phosphatase and actin regulator 2 -0.0152192
KLHL5 kelch-like family member 5 -0.0151992
SREBF2 sterol regulatory element binding transcription factor 2 -0.0151719
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.015161
DCAF10 DDB1 and CUL4 associated factor 10 -0.0151489
ZSWIM7 zinc finger, SWIM-type containing 7 -0.0151238
PLS3 plastin 3 -0.0151208
OSMR oncostatin M receptor -0.0150964
PROC protein C (inactivator of coagulation factors Va and VIIIa) -0.0150397
ORC3 origin recognition complex, subunit 3 -0.015033
LTBP1 latent transforming growth factor beta binding protein 1 -0.0150284
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 -0.014987
BZW1 basic leucine zipper and W2 domains 1 -0.0149531
PHAX phosphorylated adaptor for RNA export -0.0149506
UBE2K ubiquitin-conjugating enzyme E2K -0.014939
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0149146
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 -0.0149064
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.0148955
MSH3 mutS homolog 3 -0.0148725
MCTP1 multiple C2 domains, transmembrane 1 -0.0148316
EIF3B eukaryotic translation initiation factor 3, subunit B -0.0148271
CATSPERB catsper channel auxiliary subunit beta -0.0148154
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0147948
ZFP64 ZFP64 zinc finger protein -0.0147908
RARS1 arginyl-tRNA synthetase 1 -0.0147786
MCM3AP minichromosome maintenance complex component 3 associated protein -0.0147701
COL4A6 collagen, type IV, alpha 6 -0.0147623
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -0.0147611
CREBBP CREB binding protein -0.0147523
BAX BCL2-associated X protein -0.0147385
EPC1 enhancer of polycomb homolog 1 (Drosophila) -0.0147275
KIF21A kinesin family member 21A -0.0147253
PRPF8 pre-mRNA processing factor 8 -0.0147019
ZBTB4 zinc finger and BTB domain containing 4 -0.0146949
KLF3 Kruppel-like factor 3 (basic) -0.0146472
TCERG1 transcription elongation regulator 1 -0.0146276
PUM2 pumilio RNA-binding family member 2 -0.0146197
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.014594
JADE1 jade family PHD finger 1 -0.0145592
NIPSNAP2 nipsnap homolog 2 -0.0145586
TCF12 transcription factor 12 -0.0145584
GALM galactose mutarotase (aldose 1-epimerase) -0.0145488
DHX33 DEAH (Asp-Glu-Ala-His) box polypeptide 33 -0.014536
SYNRG synergin, gamma -0.0145355
MFSD6 major facilitator superfamily domain containing 6 -0.0145087
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) -0.0144968
SNX9 sorting nexin 9 -0.014493
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0144794
POM121C POM121 transmembrane nucleoporin C -0.0144672
RNF130 ring finger protein 130 -0.0144528