A549_GSK-LSD1 2HCl_10nM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description GSK-LSD1 2HCl 10nM perturbation in A549 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the A549_GSK-LSD1 2HCl_10nM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.205188
KRT8 keratin 8, type II 0.13093
KRT81 keratin 81, type II 0.129978
CLU clusterin 0.110167
UBL4A ubiquitin-like 4A 0.101312
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0975864
FTL ferritin, light polypeptide 0.0909021
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.0870411
ACTN4 actinin, alpha 4 0.0853306
PKM pyruvate kinase, muscle 0.073988
ENO1 enolase 1, (alpha) 0.0678831
AKR1C3 aldo-keto reductase family 1, member C3 0.0659928
AKR1C2 aldo-keto reductase family 1, member C2 0.0647583
KPNB1 karyopherin (importin) beta 1 0.0643771
GPX2 glutathione peroxidase 2 0.0592567
MKI67 marker of proliferation Ki-67 0.0588825
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.056874
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.0548817
LRP10 low density lipoprotein receptor-related protein 10 0.0537903
TM4SF1 transmembrane 4 L six family member 1 0.0537647
AGR2 anterior gradient 2 0.0531906
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0531057
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.051214
GLG1 golgi glycoprotein 1 0.0506551
NRCAM neuronal cell adhesion molecule 0.0477677
KRT18 keratin 18, type I 0.0465324
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0462106
BRCA1 breast cancer 1, early onset 0.0459098
CENPF centromere protein F, 350/400kDa 0.0449393
CA12 carbonic anhydrase XII 0.0443621
GLIS3 GLIS family zinc finger 3 0.0435998
CPLX2 complexin 2 0.0432083
IQGAP1 IQ motif containing GTPase activating protein 1 0.0421684
S100A4 S100 calcium binding protein A4 0.0404054
FTH1 ferritin, heavy polypeptide 1 0.0403678
TPI1 triosephosphate isomerase 1 0.0403615
EEF2 eukaryotic translation elongation factor 2 0.0402931
CD151 CD151 molecule (Raph blood group) 0.0397789
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 0.0396173
IGFBP4 insulin-like growth factor binding protein 4 0.0390261
RPS19 ribosomal protein S19 0.0384758
TPX2 TPX2, microtubule-associated 0.0378651
MTIF2 mitochondrial translational initiation factor 2 0.0371558
EIF4B eukaryotic translation initiation factor 4B 0.0370372
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0364506
UBTF upstream binding transcription factor, RNA polymerase I 0.036153
FLNB filamin B, beta 0.0358484
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0357816
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0356237
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0352215
PDLIM5 PDZ and LIM domain 5 0.0350201
KTN1 kinectin 1 (kinesin receptor) 0.034508
DSG2 desmoglein 2 0.0337501
TGOLN2 trans-golgi network protein 2 0.033551
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0330756
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) 0.0330711
DOCK10 dedicator of cytokinesis 10 0.0325256
UBB ubiquitin B 0.0322982
DIAPH1 diaphanous-related formin 1 0.0321462
MTDH metadherin 0.0320593
RPL31 ribosomal protein L31 0.0317618
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) 0.0313978
ERCC6L2 excision repair cross-complementation group 6-like 2 0.0310614
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.0310612
SET SET nuclear proto-oncogene 0.0308724
PCYOX1 prenylcysteine oxidase 1 0.0306742
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0305088
TPR translocated promoter region, nuclear basket protein 0.030386
PDIA6 protein disulfide isomerase family A, member 6 0.0303485
KIF5B kinesin family member 5B 0.029824
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0296711
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0294385
MUSK muscle, skeletal, receptor tyrosine kinase 0.0292595
ARHGAP35 Rho GTPase activating protein 35 0.0292538
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0290562
ZBTB38 zinc finger and BTB domain containing 38 0.028654
SETD2 SET domain containing 2 0.0284351
S100A10 S100 calcium binding protein A10 0.0283658
CENPE centromere protein E, 312kDa 0.0282689
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.0281492
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0279094
MGST1 microsomal glutathione S-transferase 1 0.0276693
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0275942
NFIB nuclear factor I/B 0.0274843
MAP1B microtubule-associated protein 1B 0.027336
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.0272696
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0269698
BRD4 bromodomain containing 4 0.0268951
HOOK3 hook microtubule-tethering protein 3 0.0266553
KRT7 keratin 7, type II 0.0265286
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0263532
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 0.0261734
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.0261582
RNF43 ring finger protein 43 0.0260714
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0258938
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0257778
TMSB4X thymosin beta 4, X-linked 0.0256283
TPM3 tropomyosin 3 0.0255371
LOC112694756 uncharaterized LOC112694756 0.0255239
RPL13A ribosomal protein L13a 0.0253635
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0252986
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0251359
RRP36 ribosomal RNA processing 36 homolog (S. cerevisiae) 0.0251201
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0250828
CLTC clathrin, heavy chain (Hc) 0.0248761
TBC1D5 TBC1 domain family, member 5 0.0248362
CAPNS1 calpain, small subunit 1 0.0248032
PLEKHA7 pleckstrin homology domain containing, family A member 7 0.0247022
TLN1 talin 1 0.0243906
IL6ST interleukin 6 signal transducer 0.0243596
DEK DEK proto-oncogene 0.0243374
HACD3 3-hydroxyacyl-CoA dehydratase 3 0.0241512
CD81 CD81 molecule 0.0240328
RPS14 ribosomal protein S14 0.023962
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0239464
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.0239058
CTSD cathepsin D 0.0238138
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.0237485
ZNF281 zinc finger protein 281 0.02361
PROCR protein C receptor, endothelial 0.0235942
RTN4 reticulon 4 0.0235427
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0233842
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0232263
AGO2 argonaute RISC catalytic component 2 0.0231174
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0230195
CREBBP CREB binding protein 0.023012
NIN ninein (GSK3B interacting protein) 0.0229132
YME1L1 YME1-like 1 ATPase 0.0228933
POLK polymerase (DNA directed) kappa 0.0228605
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0227354
RNF213 ring finger protein 213 0.0226205
SLC19A1 solute carrier family 19 (folate transporter), member 1 0.0226176
NAMPT nicotinamide phosphoribosyltransferase 0.0226142
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.0223771
SPPL3 signal peptide peptidase like 3 0.0222857
RRP1B ribosomal RNA processing 1B 0.0221822
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0221264
EXOC6B exocyst complex component 6B 0.0220292
PPP1R9A protein phosphatase 1, regulatory subunit 9A 0.0220155
BSG basigin (Ok blood group) 0.0219366
PRR11 proline rich 11 0.021894
SELENOI selenoprotein I 0.0218104
MPZL1 myelin protein zero-like 1 0.0217574
ILF3 interleukin enhancer binding factor 3, 90kDa 0.0217439
NCAPD2 non-SMC condensin I complex, subunit D2 0.0216274
CEP290 centrosomal protein 290kDa 0.021574
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.0213022
TUBB tubulin, beta class I 0.0213017
CLDN2 claudin 2 0.0212547
TKT transketolase 0.0212087
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0211998
DAD1 defender against cell death 1 0.0211466
CLPTM1 cleft lip and palate associated transmembrane protein 1 0.0211367
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) 0.0211259
VIM vimentin 0.0210028
PLEC plectin 0.0208769
MIPOL1 mirror-image polydactyly 1 0.0208103
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0207904
KIF18A kinesin family member 18A 0.0206918
NSD3 nuclear receptor binding SET domain protein 3 0.0206839
AAK1 AP2 associated kinase 1 0.0205488
ACLY ATP citrate lyase 0.0204323
RPAP2 RNA polymerase II associated protein 2 0.0203837
HSPB1 heat shock 27kDa protein 1 0.0203795
RPL29 ribosomal protein L29 0.0203199
EPB41 erythrocyte membrane protein band 4.1 0.0203031
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0202921
H4C3 H4 clustered histone 3 0.0202868
HSPH1 heat shock 105kDa/110kDa protein 1 0.0202665
RBBP7 retinoblastoma binding protein 7 0.0202163
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0200436
EMC10 ER membrane protein complex subunit 10 0.0200251
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.0200051
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0199327
ABHD2 abhydrolase domain containing 2 0.0198455
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.0197397
BUD23 BUD23 rRNA methyltransferase and ribosome maturation factor 0.0196551
ELOB elongin B 0.0196277
RBM3 RNA binding motif (RNP1, RRM) protein 3 0.0196275
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 0.0195893
ZBTB4 zinc finger and BTB domain containing 4 0.0194973
NASP nuclear autoantigenic sperm protein (histone-binding) 0.019485
LMAN2 lectin, mannose-binding 2 0.0194595
E2F3 E2F transcription factor 3 0.0194311
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0192865
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 0.0192444
PTMA prothymosin, alpha 0.019238
CD63 CD63 molecule 0.019235
RPS11 ribosomal protein S11 0.0192187
LNPEP leucyl/cystinyl aminopeptidase 0.0192181
AKAP12 A kinase (PRKA) anchor protein 12 0.0191489
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 0.0190904
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0190856
NUDCD1 NudC domain containing 1 0.0190541
SFT2D2 SFT2 domain containing 2 0.0190142
GCLM glutamate-cysteine ligase, modifier subunit 0.0189939
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 0.0188478
TXNRD1 thioredoxin reductase 1 0.0188281
TUBA1B tubulin, alpha 1b 0.0188073
PIR pirin (iron-binding nuclear protein) 0.0186686
KATNBL1 katanin p80 subunit B-like 1 0.0186618
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0186312
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 0.0185417
FGG fibrinogen gamma chain 0.0185407
ZBTB35 zinc finger and BTB domain containing 35 0.0185189
TBK1 TANK-binding kinase 1 0.0184242
CCNI cyclin I 0.0184114
RPL28 ribosomal protein L28 0.0183519
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0183506
CCT3 chaperonin containing TCP1, subunit 3 (gamma) 0.0183423
PCDH9 protocadherin 9 0.0183251
SETX senataxin 0.0183129
FAR1 fatty acyl CoA reductase 1 0.018285
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.018215
ADI1 acireductone dioxygenase 1 0.0181456
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0181345
ABTB3 ankyrin repeat and BTB domain containing 3 0.018103
ELOVL6 ELOVL fatty acid elongase 6 0.0180906
PFN1 profilin 1 0.0180639
ANXA1 annexin A1 0.0179681
COASY CoA synthase 0.0179643
HACD2 3-hydroxyacyl-CoA dehydratase 2 0.017909
HELLS helicase, lymphoid-specific 0.0178635
GPRIN3 GPRIN family member 3 0.0178284
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0178277
LY6E lymphocyte antigen 6 complex, locus E 0.017786
SIGMAR1 sigma non-opioid intracellular receptor 1 0.0177491
RPS27A ribosomal protein S27a 0.0177372
UBA2 ubiquitin-like modifier activating enzyme 2 0.017737
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0176066
PDS5A PDS5 cohesin associated factor A 0.0175568
BCAP29 B-cell receptor-associated protein 29 0.0175563
RPL10A ribosomal protein L10a 0.0175389
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0175387
EIF3B eukaryotic translation initiation factor 3, subunit B 0.0174709
RTN3 reticulon 3 0.0173737
QKI QKI, KH domain containing, RNA binding 0.0173572
RPS21 ribosomal protein S21 0.0173261
SYNGR2 synaptogyrin 2 0.0172455
RPS7 ribosomal protein S7 0.0172131
SRP72 signal recognition particle 72kDa 0.017144
ARHGAP42 Rho GTPase activating protein 42 0.0171198
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 0.0170747
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.0169617
CDK13 cyclin-dependent kinase 13 0.0169237
RPS27 ribosomal protein S27 0.0168533
CCT2 chaperonin containing TCP1, subunit 2 (beta) 0.0168041
DNAAF5 dynein, axonemal, assembly factor 5 0.0167344
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.0167292
TSKU tsukushi, small leucine rich proteoglycan 0.0167149
DGKG diacylglycerol kinase, gamma 90kDa 0.0166992
ACOX1 acyl-CoA oxidase 1, palmitoyl 0.0166733
TACC1 transforming, acidic coiled-coil containing protein 1 0.0166248
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0166072
EXO1 exonuclease 1 0.0165606
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.016544
SLC31A1 solute carrier family 31 (copper transporter), member 1 0.0165412
ASXL1 additional sex combs like transcriptional regulator 1 0.0165403
HSPA4 heat shock 70kDa protein 4 0.0164247
MEGF9 multiple EGF-like-domains 9 0.0164103
ACBD5 acyl-CoA binding domain containing 5 0.0163967
CLASP2 cytoplasmic linker associated protein 2 0.016395
FTSJ3 FtsJ homolog 3 (E. coli) 0.0163738
PPP4R3B protein phosphatase 4 regulatory subunit 3B 0.0163613
MCM4 minichromosome maintenance complex component 4 0.0163558
RPL37 ribosomal protein L37 0.0163413
GDI2 GDP dissociation inhibitor 2 0.0163384
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0163106
TALDO1 transaldolase 1 0.0162533
COPB1 coatomer protein complex, subunit beta 1 0.0162115
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0162103
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0162056
NUP205 nucleoporin 205kDa 0.0161273
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) 0.0161186
ZC3H8 zinc finger CCCH-type containing 8 0.0160016
FAM135A family with sequence similarity 135, member A 0.0159899
EML4 echinoderm microtubule associated protein like 4 0.0159673
PLD3 phospholipase D family, member 3 0.0159621
NEO1 neogenin 1 0.0159472
ATP5F1A ATP synthase F1 subunit alpha 0.0159359
KIF13B kinesin family member 13B 0.0159294
RPL5 ribosomal protein L5 0.0159233
ZFR zinc finger RNA binding protein 0.0159054
RPS29 ribosomal protein S29 0.0158767
DHRS7 dehydrogenase/reductase (SDR family) member 7 0.0158748
BLTP3A bridge-like lipid transfer protein family member 3A 0.0158742
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa 0.0158636
ATP5MC2 ATP synthase membrane subunit c locus 2 0.0157841
JUP junction plakoglobin 0.0157834
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor 0.0157539
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0157202
KIAA0232 KIAA0232 0.0157154
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0156783
WDPCP WD repeat containing planar cell polarity effector 0.0156023
DMXL2 Dmx-like 2 0.0155467
SMC6 structural maintenance of chromosomes 6 0.0155341
PXMP2 peroxisomal membrane protein 2, 22kDa 0.0154124
TCF12 transcription factor 12 0.0153922
PDS5B PDS5 cohesin associated factor B 0.015365
TMTC3 transmembrane and tetratricopeptide repeat containing 3 0.0153443
OSBPL3 oxysterol binding protein-like 3 0.0153211
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0153195
ZNF146 zinc finger protein 146 0.0153046
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 0.0153037
ZFHX3 zinc finger homeobox 3 0.0153018
RNF103-CHMP3 RNF103-CHMP3 readthrough 0.0152925
MON1B MON1 secretory trafficking family member B 0.015287
CENPB centromere protein B, 80kDa 0.0152797
DSCAM Down syndrome cell adhesion molecule 0.0152033
ACOD1 aconitate decarboxylase 1 0.0151925
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) 0.0151857
ACTG1 actin gamma 1 0.0151385
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.015135
ARHGAP24 Rho GTPase activating protein 24 0.0151329
CCT7 chaperonin containing TCP1, subunit 7 (eta) 0.0151238
RPL37A ribosomal protein L37a 0.0150979
ADAM17 ADAM metallopeptidase domain 17 0.0150873
UQCRC1 ubiquinol-cytochrome c reductase core protein I 0.0150648
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0150153
METTL8 methyltransferase like 8 0.0149803
CANT1 calcium activated nucleotidase 1 0.0149689
HNF1A HNF1 homeobox A 0.0149136
TPM4 tropomyosin 4 0.0149052
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0149032
EIF3D eukaryotic translation initiation factor 3, subunit D 0.0148915
SYAP1 synapse associated protein 1 0.0148789
SEC62 SEC62 homolog (S. cerevisiae) 0.0148522
FYCO1 FYVE and coiled-coil domain containing 1 0.0148207
TRIM28 tripartite motif containing 28 0.0148105
HAUS6 HAUS augmin-like complex, subunit 6 0.0148077
MRPS27 mitochondrial ribosomal protein S27 0.0147882
ARHGAP10 Rho GTPase activating protein 10 0.0147551
SAMD8 sterile alpha motif domain containing 8 0.0147532
KIF1C kinesin family member 1C 0.0147215
RHBDD3 rhomboid domain containing 3 0.0146652
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0146275
ZNHIT1 zinc finger, HIT-type containing 1 0.0146234
EZR ezrin 0.0146098
ATL3 atlastin GTPase 3 0.0146049
SMAP1 small ArfGAP 1 0.0145498
SCLT1 sodium channel and clathrin linker 1 0.0145038
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0144769
RUVBL2 RuvB-like AAA ATPase 2 0.0144623
WSB1 WD repeat and SOCS box containing 1 0.0144576
GCFC2 GC-rich sequence DNA-binding factor 2 0.014445
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae) 0.014438
RSU1 Ras suppressor protein 1 0.0144366
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0144143
SAFB scaffold attachment factor B 0.0144032
ELOVL5 ELOVL fatty acid elongase 5 0.0143613
SSB Sjogren syndrome antigen B (autoantigen La) 0.0143049
DHX37 DEAH (Asp-Glu-Ala-His) box polypeptide 37 0.0142992
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) 0.0142832
CHD4 chromodomain helicase DNA binding protein 4 0.0142802
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0142586
NPPC natriuretic peptide C 0.0142487
PTPRG protein tyrosine phosphatase, receptor type, G 0.0140792
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 0.0140752
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.0140709
MED27 mediator complex subunit 27 0.0140638
ETF1 eukaryotic translation termination factor 1 0.014029
TSC22D1 TSC22 domain family, member 1 0.0140209
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.0140013
SH3RF1 SH3 domain containing ring finger 1 0.0139979
FAM234A family with sequence similarity 234 member A 0.0139921
BRI3BP BRI3 binding protein 0.0139871
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 0.0139709
MRPS18B mitochondrial ribosomal protein S18B 0.0139601
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) 0.0139595
FGL1 fibrinogen-like 1 0.0139111
TMEM33 transmembrane protein 33 0.0138542
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 0.0137775
TMEM64 transmembrane protein 64 0.0137647
TM4SF20 transmembrane 4 L six family member 20 0.0137372
STRBP spermatid perinuclear RNA binding protein 0.0137272
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0136968
NHLRC2 NHL repeat containing 2 0.013693
SREBF1 sterol regulatory element binding transcription factor 1 0.0136805
ANKRD16 ankyrin repeat domain 16 0.0136183
ATG9A autophagy related 9A 0.013608
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits 0.0135724
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0135649
FLII flightless I homolog (Drosophila) 0.0135458
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 0.0135381
RPSA ribosomal protein SA 0.0135251
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1) 0.01349
TFAM transcription factor A, mitochondrial 0.0134508
B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 0.0134335
PPP6R1 protein phosphatase 6, regulatory subunit 1 0.0134195
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) 0.0134184
CPSF2 cleavage and polyadenylation specific factor 2, 100kDa 0.0134183
TRAPPC3 trafficking protein particle complex 3 0.0134033
SNF8 SNF8, ESCRT-II complex subunit 0.0134001
EPC1 enhancer of polycomb homolog 1 (Drosophila) 0.0133796
PRKX protein kinase, X-linked 0.0133698
PEAK1 pseudopodium-enriched atypical kinase 1 0.0133576
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0133533
NCAPG non-SMC condensin I complex, subunit G 0.0133522
SMG6 SMG6 nonsense mediated mRNA decay factor 0.013332
CADM2 cell adhesion molecule 2 0.01333
TMEM65 transmembrane protein 65 0.0133252
USP12 ubiquitin specific peptidase 12 0.013321
TACR1 tachykinin receptor 1 0.0133006
RPL4 ribosomal protein L4 0.0132607
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant 0.0132334
GDE1 glycerophosphodiester phosphodiesterase 1 0.0132261
PRC1 protein regulator of cytokinesis 1 0.0132076
TMEM97 transmembrane protein 97 0.0132024
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa 0.0131986
TTC17 tetratricopeptide repeat domain 17 0.0131889
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0131641
ACOT7 acyl-CoA thioesterase 7 0.0131577
PCM1 pericentriolar material 1 0.0131542
FAM174C family with sequence similarity 174 member C 0.0131524
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 0.0131523
AGMO alkylglycerol monooxygenase 0.0131422
TOP1 topoisomerase (DNA) I 0.0131389
FGFR1 fibroblast growth factor receptor 1 0.0131234
CHD3 chromodomain helicase DNA binding protein 3 0.0131072
CLIP1 CAP-GLY domain containing linker protein 1 0.0131033
PBX3 pre-B-cell leukemia homeobox 3 0.0130981
TARS1 threonyl-tRNA synthetase 1 0.0130837
GPR107 G protein-coupled receptor 107 0.0130757
HP1BP3 heterochromatin protein 1, binding protein 3 0.0130696
ZNF24 zinc finger protein 24 0.0130637
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 0.0130488
FXN frataxin 0.013031
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.0129885
NUMB numb homolog (Drosophila) 0.0129816
TRIM44 tripartite motif containing 44 0.0129661
PIBF1 progesterone immunomodulatory binding factor 1 0.0129606
RARS2 arginyl-tRNA synthetase 2, mitochondrial 0.0129146
TASOR2 transcription activation suppressor family member 2 0.0128997
CREG1 cellular repressor of E1A-stimulated genes 1 0.0128905
ITPRIPL2 inositol 1,4,5-trisphosphate receptor interacting protein-like 2 0.0128636
CEP120 centrosomal protein 120kDa 0.0128545
MARCHF7 membrane associated ring-CH-type finger 7 0.0128249
LATS1 large tumor suppressor kinase 1 0.0128241
GNA12 guanine nucleotide binding protein (G protein) alpha 12 0.0128084
CDK4 cyclin-dependent kinase 4 0.0128005
UBP1 upstream binding protein 1 (LBP-1a) 0.0127954
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.0127952
NHP2 NHP2 ribonucleoprotein 0.0127914
ECE1 endothelin converting enzyme 1 0.0127587
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha 0.0127427
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0127128
PTK2B protein tyrosine kinase 2 beta 0.0127082
ZC3H13 zinc finger CCCH-type containing 13 0.012682
TGFBRAP1 transforming growth factor, beta receptor associated protein 1 0.0126801
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.01268
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 0.0126667
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa 0.012663
TM4SF18 transmembrane 4 L six family member 18 0.0126473
BLTP2 bridge-like lipid transfer protein family member 2 0.0126424
ARL4C ADP-ribosylation factor-like 4C 0.0126415
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0126389
HEATR1 HEAT repeat containing 1 0.0126268
MBD4 methyl-CpG binding domain protein 4 0.012622
IMMT inner membrane protein, mitochondrial 0.0126204
DDRGK1 DDRGK domain containing 1 0.0126082
MIS18BP1 MIS18 binding protein 1 0.0125952
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 0.0125928
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 0.0125794
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0125719
ARF3 ADP-ribosylation factor 3 0.0125549
TBC1D14 TBC1 domain family, member 14 0.012554
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.0125251
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0125143
RBBP6 retinoblastoma binding protein 6 0.0125092
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 0.0125058
RPS25 ribosomal protein S25 0.0125028
MGA MGA, MAX dimerization protein 0.0124885
ZNF260 zinc finger protein 260 0.0124816
SOGA1 suppressor of glucose, autophagy associated 1 0.0124798
NT5C3A 5'-nucleotidase, cytosolic IIIA 0.0124796
UBA1 ubiquitin-like modifier activating enzyme 1 0.0124762
ESD esterase D 0.0124704
RAB3B RAB3B, member RAS oncogene family 0.0124492
YBX3 Y box binding protein 3 0.0124424
GOLGA2 golgin A2 0.0123961
JAK2 Janus kinase 2 0.0123939
H3-3B H3.3 histone B 0.0123799
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0123563
AUP1 ancient ubiquitous protein 1 0.0123551
RABL6 RAB, member RAS oncogene family-like 6 0.0123512
SACS sacsin molecular chaperone 0.0123485
SGO2 shugoshin 2 0.0123403
RRM1 ribonucleotide reductase M1 0.012257
MAVS mitochondrial antiviral signaling protein 0.0122404
BCAT2 branched chain amino-acid transaminase 2, mitochondrial 0.0122076
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0121892
STAMBP STAM binding protein 0.0121631
SYNPO synaptopodin 0.0121489
SATB2 SATB homeobox 2 0.012139
NIPSNAP1 nipsnap homolog 1 (C. elegans) 0.0121357
C21ORF58 chromosome 21 open reading frame 58 0.0121243
KIF4A kinesin family member 4A 0.0121183
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.0121138
CNOT6 CCR4-NOT transcription complex, subunit 6 0.0120984
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0120926

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.180181
THSD4 thrombospondin, type I, domain containing 4 -0.124592
CNTN1 contactin 1 -0.0988601
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0943852
PRKCA protein kinase C, alpha -0.0933079
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0916535
MYO1E myosin IE -0.0853481
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0798782
PATJ PATJ crumbs cell polarity complex component -0.0752994
MED13L mediator complex subunit 13-like -0.0687898
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0672817
CNTNAP3B contactin associated protein-like 3B -0.0607131
BCAS3 breast carcinoma amplified sequence 3 -0.0601829
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0582622
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0563687
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0562533
CUEDC1 CUE domain containing 1 -0.0561691
PDE4B phosphodiesterase 4B, cAMP-specific -0.055243
MAML3 mastermind-like 3 (Drosophila) -0.0549464
NRG1 neuregulin 1 -0.0547485
BICC1 BicC family RNA binding protein 1 -0.0543597
NFIA nuclear factor I/A -0.0508606
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0507524
PTGR1 prostaglandin reductase 1 -0.0503246
FAF1 Fas (TNFRSF6) associated factor 1 -0.0494731
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0492923
USP34 ubiquitin specific peptidase 34 -0.0481939
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.0475901
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0471552
APP amyloid beta (A4) precursor protein -0.0464215
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0461894
PDE8A phosphodiesterase 8A -0.0461143
KYNU kynureninase -0.0460274
ZBTB20 zinc finger and BTB domain containing 20 -0.0458774
UBAP2 ubiquitin associated protein 2 -0.0456121
ACACA acetyl-CoA carboxylase alpha -0.0449905
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0447314
ANXA4 annexin A4 -0.0430267
MPG N-methylpurine-DNA glycosylase -0.0425703
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0413296
PSD3 pleckstrin and Sec7 domain containing 3 -0.0408072
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0405896
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0404202
UBE2H ubiquitin-conjugating enzyme E2H -0.040164
CHD9 chromodomain helicase DNA binding protein 9 -0.0394579
HIPK2 homeodomain interacting protein kinase 2 -0.0394513
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0394366
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0385178
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0385003
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 -0.0381229
RSF1 remodeling and spacing factor 1 -0.0376873
SYT1 synaptotagmin I -0.0376062
PBX1 pre-B-cell leukemia homeobox 1 -0.0372594
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0371632
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0360864
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0360305
FBXL20 F-box and leucine-rich repeat protein 20 -0.0360179
USP6NL USP6 N-terminal like -0.0359276
CCDC57 coiled-coil domain containing 57 -0.035291
TACC2 transforming, acidic coiled-coil containing protein 2 -0.0352649
RBM47 RNA binding motif protein 47 -0.034671
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase -0.0345578
SMAD3 SMAD family member 3 -0.0344312
SHLD1 shieldin complex subunit 1 -0.0342302
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0340303
SLC35F3 solute carrier family 35, member F3 -0.0333809
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0331008
WWTR1 WW domain containing transcription regulator 1 -0.033098
RORA RAR-related orphan receptor A -0.0329992
STX8 syntaxin 8 -0.0326916
OPHN1 oligophrenin 1 -0.0326715
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.0325945
MCU mitochondrial calcium uniporter -0.0325033
SVIL supervillin -0.032194
EVA1C eva-1 homolog C (C. elegans) -0.0318733
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0313054
DENND5B DENN/MADD domain containing 5B -0.0311868
PCDHB16 protocadherin beta 16 -0.0310257
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0309514
CRTC3 CREB regulated transcription coactivator 3 -0.0305896
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0305139
LRMDA leucine rich melanocyte differentiation associated -0.0304721
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0304167
RAP1B RAP1B, member of RAS oncogene family -0.030384
TLK2 tousled-like kinase 2 -0.0303778
FHIT fragile histidine triad -0.0302971
NPEPPS aminopeptidase puromycin sensitive -0.0302636
NCOA3 nuclear receptor coactivator 3 -0.0300553
AHCYL2 adenosylhomocysteinase-like 2 -0.0299121
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 -0.0298749
PIAS1 protein inhibitor of activated STAT, 1 -0.0297624
FOXP1 forkhead box P1 -0.0295273
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.029235
SH3D19 SH3 domain containing 19 -0.029095
GMDS GDP-mannose 4,6-dehydratase -0.0287257
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0285822
GPHN gephyrin -0.0280084
PCSK5 proprotein convertase subtilisin/kexin type 5 -0.027988
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0277484
NCOA2 nuclear receptor coactivator 2 -0.0277134
AOPEP aminopeptidase O (putative) -0.0276825
HDAC8 histone deacetylase 8 -0.0276536
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0274657
QRICH1 glutamine-rich 1 -0.0273967
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -0.0273519
CDR2 cerebellar degeneration-related protein 2, 62kDa -0.0272992
NCOR2 nuclear receptor corepressor 2 -0.0269252
THOC2 THO complex 2 -0.0268199
SREBF2 sterol regulatory element binding transcription factor 2 -0.0267948
SETD5 SET domain containing 5 -0.0267548
LMTK2 lemur tyrosine kinase 2 -0.0267356
SETBP1 SET binding protein 1 -0.0266534
SSH2 slingshot protein phosphatase 2 -0.0264076
ITSN2 intersectin 2 -0.0261939
COL4A5 collagen, type IV, alpha 5 -0.0261834
NSRP1 nuclear speckle splicing regulatory protein 1 -0.0261517
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0260887
LMBR1 limb development membrane protein 1 -0.0259537
SQSTM1 sequestosome 1 -0.0258151
PRKCE protein kinase C, epsilon -0.0257719
USP24 ubiquitin specific peptidase 24 -0.0257082
EFNA5 ephrin-A5 -0.0256702
LPAR1 lysophosphatidic acid receptor 1 -0.0256376
PDLIM1 PDZ and LIM domain 1 -0.0255998
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0254351
NCOR1 nuclear receptor corepressor 1 -0.0254283
MYO1D myosin ID -0.025311
MTA3 metastasis associated 1 family, member 3 -0.0252363
PLPP1 phospholipid phosphatase 1 -0.0251734
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0250501
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0248098
UBR4 ubiquitin protein ligase E3 component n-recognin 4 -0.0247815
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0246697
PPP1R21 protein phosphatase 1, regulatory subunit 21 -0.0244373
PCGF6 polycomb group ring finger 6 -0.0243565
TANK TRAF family member-associated NFKB activator -0.0243323
ARHGAP26 Rho GTPase activating protein 26 -0.0242581
PLCE1 phospholipase C, epsilon 1 -0.0242555
GPATCH8 G patch domain containing 8 -0.0242185
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0239791
PNKP polynucleotide kinase 3'-phosphatase -0.0239439
UNK unkempt family zinc finger -0.0238507
CAMKMT calmodulin-lysine N-methyltransferase -0.0238498
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -0.0237347
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.023663
DENND4A DENN/MADD domain containing 4A -0.0235564
TRAPPC9 trafficking protein particle complex 9 -0.0234687
ACBD3 acyl-CoA binding domain containing 3 -0.0234531
DNAAF9 dynein axonemal assembly factor 9 -0.0232287
DOCK1 dedicator of cytokinesis 1 -0.0231885
CNKSR3 CNKSR family member 3 -0.0231879
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.023022
SEPTIN6 septin 6 -0.0230016
LHFPL2 lipoma HMGIC fusion partner-like 2 -0.0229328
PER2 period circadian clock 2 -0.0227249
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.0227211
MACROH2A1 macroH2A.1 histone -0.0227079
HIP1 huntingtin interacting protein 1 -0.0226128
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0226
MSH3 mutS homolog 3 -0.0224604
MPHOSPH9 M-phase phosphoprotein 9 -0.0224348
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 -0.0222629
RPL18 ribosomal protein L18 -0.022225
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 -0.0222124
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0221808
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 -0.0221501
RPLP1 ribosomal protein, large, P1 -0.0220636
PLS1 plastin 1 -0.0219203
UTRN utrophin -0.0219131
RRBP1 ribosome binding protein 1 -0.0217639
C1RL complement component 1, r subcomponent-like -0.0217294
MBNL1 muscleblind-like splicing regulator 1 -0.0216184
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0215611
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0214917
INVS inversin -0.0214564
DOCK5 dedicator of cytokinesis 5 -0.0213837
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0213717
HM13 histocompatibility (minor) 13 -0.0213358
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0212988
URI1 URI1, prefoldin-like chaperone -0.0211191
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.021117
LTBP4 latent transforming growth factor beta binding protein 4 -0.0210662
GCN1 GCN1 activator of EIF2AK4 -0.0210583
NRIP1 nuclear receptor interacting protein 1 -0.0210478
TTC28 tetratricopeptide repeat domain 28 -0.0210345
LTBP1 latent transforming growth factor beta binding protein 1 -0.0210318
TFCP2 transcription factor CP2 -0.0210256
PIKFYVE phosphoinositide kinase, FYVE finger containing -0.0208668
RHOT1 ras homolog family member T1 -0.0207514
COP1 COP1 E3 ubiquitin ligase -0.020726
ZNF652 zinc finger protein 652 -0.0207133
NUBPL nucleotide binding protein-like -0.0204749
PPIA peptidylprolyl isomerase A (cyclophilin A) -0.0204747
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 -0.0204699
FLVCR1 feline leukemia virus subgroup C cellular receptor 1 -0.020457
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0204423
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B -0.0204396
ZDHHC17 zinc finger, DHHC-type containing 17 -0.0203534
HIPK3 homeodomain interacting protein kinase 3 -0.0203201
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 -0.0203164
TTL tubulin tyrosine ligase -0.0202957
STK24 serine/threonine kinase 24 -0.0202573
SEPTIN9 septin 9 -0.02008
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 -0.0199988
FRK fyn-related Src family tyrosine kinase -0.0199955
CRLF3 cytokine receptor-like factor 3 -0.019985
LRRK1 leucine-rich repeat kinase 1 -0.0199748
COPA coatomer protein complex, subunit alpha -0.0199573
VEZT vezatin, adherens junctions transmembrane protein -0.0198824
ZNF609 zinc finger protein 609 -0.0198273
NOVA1 neuro-oncological ventral antigen 1 -0.0197932
TP53 tumor protein p53 -0.0197676
VPS35L VPS35 endosomal protein sorting factor like -0.0197523
TPCN1 two pore segment channel 1 -0.0197273
MLPH melanophilin -0.019691
APTX aprataxin -0.0196321
THRB thyroid hormone receptor, beta -0.0195911
BTBD9 BTB (POZ) domain containing 9 -0.0195459
SCMH1 sex comb on midleg homolog 1 (Drosophila) -0.0195263
TM9SF3 transmembrane 9 superfamily member 3 -0.0194241
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -0.0193959
CMIP c-Maf inducing protein -0.019381
FOXJ3 forkhead box J3 -0.0192901
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 -0.0192526
OLA1 Obg-like ATPase 1 -0.0192265
CD44 CD44 molecule (Indian blood group) -0.0191783
SRPK2 SRSF protein kinase 2 -0.0191735
MYO9A myosin IXA -0.0191229
KANK1 KN motif and ankyrin repeat domains 1 -0.0191182
PARD3 par-3 family cell polarity regulator -0.0190505
AARS1 alanyl-tRNA synthetase 1 -0.0190228
RBM20 RNA binding motif protein 20 -0.0190002
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0189952
ANKRD44 ankyrin repeat domain 44 -0.0189318
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0189232
WWOX WW domain containing oxidoreductase -0.01891
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 -0.0188778
BIRC6 baculoviral IAP repeat containing 6 -0.0187963
XRN1 5'-3' exoribonuclease 1 -0.0187946
ZNF566 zinc finger protein 566 -0.0187633
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0187589
PDIA4 protein disulfide isomerase family A, member 4 -0.0187018
RHOBTB1 Rho-related BTB domain containing 1 -0.0186551
TOM1L2 target of myb1-like 2 (chicken) -0.0185844
WAC WW domain containing adaptor with coiled-coil -0.0185701
KHDC4 KH domain containing 4, pre-mRNA splicing factor -0.0185501
PHKB phosphorylase kinase, beta -0.0185418
PLCH1 phospholipase C, eta 1 -0.0185122
NINL ninein-like -0.0184615
RBM39 RNA binding motif protein 39 -0.0184389
ACTN1 actinin, alpha 1 -0.018429
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0184104
GCC2 GRIP and coiled-coil domain containing 2 -0.018401
LTAP1 lipid transport auxiliary protein 1 -0.018375
SPNS1 spinster homolog 1 (Drosophila) -0.018373
PKN1 protein kinase N1 -0.0183036
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0182892
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0182623
SLC25A43 solute carrier family 25, member 43 -0.018262
ATRN attractin -0.0180211
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -0.0179695
EVI5 ecotropic viral integration site 5 -0.0179022
SLCO3A1 solute carrier organic anion transporter family, member 3A1 -0.0178868
ACBD6 acyl-CoA binding domain containing 6 -0.0178828
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha -0.01783
SLC39A11 solute carrier family 39, member 11 -0.0178005
ILKAP integrin-linked kinase-associated serine/threonine phosphatase -0.0177925
NCOA6 nuclear receptor coactivator 6 -0.0177675
CDKL5 cyclin-dependent kinase-like 5 -0.0177658
BMPR1B bone morphogenetic protein receptor, type IB -0.0177244
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0177198
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0177113
RRAS2 related RAS viral (r-ras) oncogene homolog 2 -0.0176738
SDCCAG8 serologically defined colon cancer antigen 8 -0.0176182
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0176079
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0175791
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0175381
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0174941
PDAP1 PDGFA associated protein 1 -0.0174871
TNPO1 transportin 1 -0.0174768
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0174226
RBM41 RNA binding motif protein 41 -0.0173929
PRPF38B pre-mRNA processing factor 38B -0.0173875
SNX9 sorting nexin 9 -0.0173426
ARHGAP12 Rho GTPase activating protein 12 -0.0173399
FGA fibrinogen alpha chain -0.0173046
AHNAK AHNAK nucleoprotein -0.0172903
AREG amphiregulin -0.017269
ANKH ANKH inorganic pyrophosphate transport regulator -0.0172608
SNX29 sorting nexin 29 -0.0172162
NUP153 nucleoporin 153kDa -0.0172142
ELOF1 elongation factor 1 homolog (S. cerevisiae) -0.0171909
EXD3 exonuclease 3'-5' domain containing 3 -0.0171657
SEC22C SEC22 vesicle trafficking protein homolog C (S. cerevisiae) -0.0171621
RSRC1 arginine/serine-rich coiled-coil 1 -0.0171455
MORF4L2 mortality factor 4 like 2 -0.0170841
SEC24B SEC24 family member B -0.0169751
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 -0.0169582
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G -0.0169224
PLAUR plasminogen activator, urokinase receptor -0.0169196
RASSF9 Ras association (RalGDS/AF-6) domain family (N-terminal) member 9 -0.0169027
CDC42SE2 CDC42 small effector 2 -0.0167994
LUC7L LUC7-like (S. cerevisiae) -0.0167934
BEND7 BEN domain containing 7 -0.016787
RPS5 ribosomal protein S5 -0.0167572
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0167371
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) -0.0167176
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0166666
LAMB1 laminin, beta 1 -0.0166566
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 -0.0166427
ANKRD17 ankyrin repeat domain 17 -0.0166406
DEAF1 DEAF1 transcription factor -0.0166355
VRK2 vaccinia related kinase 2 -0.0165975
RCOR3 REST corepressor 3 -0.0165434
TBC1D15 TBC1 domain family, member 15 -0.0165342
ZNF592 zinc finger protein 592 -0.0165244
RABGAP1L RAB GTPase activating protein 1-like -0.0165221
AIG1 androgen-induced 1 -0.0164987
SS18 synovial sarcoma translocation, chromosome 18 -0.016487
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 -0.0164734
FBXL17 F-box and leucine-rich repeat protein 17 -0.016467
LARP4 La ribonucleoprotein domain family, member 4 -0.016465
VCAN versican -0.0164606
ABHD12 abhydrolase domain containing 12 -0.016443
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0164012
BCAR3 breast cancer anti-estrogen resistance 3 -0.0163992
RC3H2 ring finger and CCCH-type domains 2 -0.0163942
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 -0.0163924
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0163779
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0163761
KAT6B K(lysine) acetyltransferase 6B -0.016346
FBXO11 F-box protein 11 -0.0162462
AKAP10 A kinase (PRKA) anchor protein 10 -0.01622
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme -0.0162177
PTK2 protein tyrosine kinase 2 -0.0162113
EXOC4 exocyst complex component 4 -0.0161904
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0161903
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0161784
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0161538
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0161304
METTL15 methyltransferase like 15 -0.0161194
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -0.016084
NIPBL Nipped-B homolog (Drosophila) -0.0160135
C2ORF42 chromosome 2 open reading frame 42 -0.0160071
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 -0.0159785
CNOT10 CCR4-NOT transcription complex, subunit 10 -0.0159437
PPP1R12B protein phosphatase 1, regulatory subunit 12B -0.0159311
IQCB1 IQ motif containing B1 -0.0159254
SH3PXD2A SH3 and PX domains 2A -0.0159047
RUFY2 RUN and FYVE domain containing 2 -0.0159005
ANO6 anoctamin 6 -0.0158959
SLA2 Src-like-adaptor 2 -0.0158545
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0158438
GOLIM4 golgi integral membrane protein 4 -0.0158366
CFLAR CASP8 and FADD-like apoptosis regulator -0.015817
ITGB4 integrin, beta 4 -0.0157396
RAI14 retinoic acid induced 14 -0.0157144
NBEA neurobeachin -0.0156925
THSD7A thrombospondin, type I, domain containing 7A -0.0156853
RIN3 Ras and Rab interactor 3 -0.0156572
FLOT2 flotillin 2 -0.0156522
MYADM myeloid-associated differentiation marker -0.0156056
ETFA electron-transfer-flavoprotein, alpha polypeptide -0.0155762
ZNF780B zinc finger protein 780B -0.0155715
PGAP1 post-GPI attachment to proteins 1 -0.0154844
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0154757
CBR4 carbonyl reductase 4 -0.0154365
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.0154328
ZNF704 zinc finger protein 704 -0.0154276
ZNHIT6 zinc finger, HIT-type containing 6 -0.0154191
FAM177A1 family with sequence similarity 177, member A1 -0.0153968
EXOC2 exocyst complex component 2 -0.0153948
PALLD palladin, cytoskeletal associated protein -0.0153764
FCHSD2 FCH and double SH3 domains 2 -0.0153729
PON3 paraoxonase 3 -0.01537
ZNF292 zinc finger protein 292 -0.015327
PDCD6IP programmed cell death 6 interacting protein -0.015292
NAE1 NEDD8 activating enzyme E1 subunit 1 -0.0152586
RAB14 RAB14, member RAS oncogene family -0.0152517
FAM222B family with sequence similarity 222, member B -0.0152501
CMTM4 CKLF-like MARVEL transmembrane domain containing 4 -0.0152292
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0152161
CLASP1 cytoplasmic linker associated protein 1 -0.0151975
PHF21A PHD finger protein 21A -0.0151971
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) -0.0151571
ZNF235 zinc finger protein 235 -0.0151236
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0150926
SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 -0.0150848
FTO fat mass and obesity associated -0.0150799
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 -0.0150704
EXT1 exostosin glycosyltransferase 1 -0.0150555
RPS18 ribosomal protein S18 -0.0150508
RPS9 ribosomal protein S9 -0.0150442
FN1 fibronectin 1 -0.0150356
SH3KBP1 SH3-domain kinase binding protein 1 -0.0149947
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0149815
PHPT1 phosphohistidine phosphatase 1 -0.0149796
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.01493
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0149088
EPN2 epsin 2 -0.0148976
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0148932
OGG1 8-oxoguanine DNA glycosylase -0.0148848
DUSP4 dual specificity phosphatase 4 -0.0148274
CTBP2 C-terminal binding protein 2 -0.0148257
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0147827
OSTM1 osteopetrosis associated transmembrane protein 1 -0.0147585
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0147502
PTPRM protein tyrosine phosphatase, receptor type, M -0.0147432
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0147321
PLEKHM3 pleckstrin homology domain containing, family M, member 3 -0.014722
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -0.0146749
ACAD10 acyl-CoA dehydrogenase family, member 10 -0.0146415
TRAM1 translocation associated membrane protein 1 -0.0146286
AP2A2 adaptor-related protein complex 2, alpha 2 subunit -0.0145872
GOLPH3L golgi phosphoprotein 3-like -0.0145858
DGLUCY D-glutamate cyclase -0.0145675
RBM10 RNA binding motif protein 10 -0.014557
RIOK3 RIO kinase 3 -0.0145487
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0145274
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0145256
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0144878
NCKAP5 NCK-associated protein 5 -0.0144828
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 -0.0144715
NDRG3 NDRG family member 3 -0.0144532
RPH3AL rabphilin 3A-like (without C2 domains) -0.0144256
TMEM131 transmembrane protein 131 -0.0144241
ITCH itchy E3 ubiquitin protein ligase -0.0144102
CUL5 cullin 5 -0.0143874
FBXW8 F-box and WD repeat domain containing 8 -0.0143377
CCSER2 coiled-coil serine-rich protein 2 -0.0143281
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 -0.0143243
KDM6A lysine (K)-specific demethylase 6A -0.014315
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0142937
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0142358
KIAA1549 KIAA1549 -0.0142105
MCM9 minichromosome maintenance complex component 9 -0.0142052
PCSK7 proprotein convertase subtilisin/kexin type 7 -0.0141785
TMEM135 transmembrane protein 135 -0.0141778
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type -0.0141436
TMEM123 transmembrane protein 123 -0.0141338
TPST1 tyrosylprotein sulfotransferase 1 -0.0141272
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0141269
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0141048
RARS1 arginyl-tRNA synthetase 1 -0.0140941
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0140753
FAT1 FAT atypical cadherin 1 -0.014075
FILIP1 filamin A interacting protein 1 -0.0140646
KRCC1 lysine-rich coiled-coil 1 -0.0140569
ATM ATM serine/threonine kinase -0.0140551
SNW1 SNW domain containing 1 -0.0140392
WDR20 WD repeat domain 20 -0.0140337
RHEB Ras homolog enriched in brain -0.0140213
GRAMD1B GRAM domain containing 1B -0.0140196
CLASRP CLK4-associating serine/arginine rich protein -0.0140031
TET3 tet methylcytosine dioxygenase 3 -0.0139972
ARL15 ADP-ribosylation factor-like 15 -0.0139891
PDE10A phosphodiesterase 10A -0.0139827
SRSF4 serine/arginine-rich splicing factor 4 -0.0139817
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 -0.0139715
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0139683
CDK8 cyclin-dependent kinase 8 -0.0139485
TPD52L1 tumor protein D52-like 1 -0.0139113
CKAP4 cytoskeleton-associated protein 4 -0.0139029
ELP4 elongator acetyltransferase complex subunit 4 -0.0138862
C6ORF89 chromosome 6 open reading frame 89 -0.0138151
TCP11L2 t-complex 11, testis-specific-like 2 -0.0138093
RNF217 ring finger protein 217 -0.0137975
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 -0.0137881
MAPK9 mitogen-activated protein kinase 9 -0.0137813
USO1 USO1 vesicle transport factor -0.0137295
TBC1D23 TBC1 domain family, member 23 -0.0137227
ARHGAP5 Rho GTPase activating protein 5 -0.0137194
NUP133 nucleoporin 133kDa -0.0137164
FAM107B family with sequence similarity 107, member B -0.0137024
INSR insulin receptor -0.0136958
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.0136941
SYNGAP1 synaptic Ras GTPase activating protein 1 -0.0136723
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2 -0.0136563
GLDC glycine dehydrogenase (decarboxylating) -0.0136533
MIA2 melanoma inhibitory activity 2 -0.0136368
UVRAG UV radiation resistance associated -0.0136318
RPS23 ribosomal protein S23 -0.0136273
SEC11A SEC11 homolog A (S. cerevisiae) -0.0136021
PARVB parvin, beta -0.0135747
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) -0.0135494
ABI1 abl-interactor 1 -0.0135463
PDE7A phosphodiesterase 7A -0.0135449
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0135319
NT5C2 5'-nucleotidase, cytosolic II -0.0135275
ANO10 anoctamin 10 -0.0135107
TOP6BL TOP6B like initiator of meiotic double strand breaks -0.0134894
INO80 INO80 complex subunit -0.0134647
SDAD1 SDA1 domain containing 1 -0.0133943
DSTN destrin (actin depolymerizing factor) -0.0133818
CFDP1 craniofacial development protein 1 -0.013328
CALR calreticulin -0.013312
UNC13B unc-13 homolog B (C. elegans) -0.0133111
NRP1 neuropilin 1 -0.0133089
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.0132904
NUCB1 nucleobindin 1 -0.0132644