A549_NVP-BSK805 2HCl_1µM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description NVP-BSK805 2HCl 1µM perturbation in A549 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the A549_NVP-BSK805 2HCl_1µM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide 0.141384
AKR1C2 aldo-keto reductase family 1, member C2 0.139897
SPTBN1 spectrin, beta, non-erythrocytic 1 0.115288
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0937459
KRT8 keratin 8, type II 0.0924623
CA12 carbonic anhydrase XII 0.0848507
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0826636
UBL4A ubiquitin-like 4A 0.0754151
RAB10 RAB10, member RAS oncogene family 0.0751672
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.072798
KRT18 keratin 18, type I 0.0718189
NRCAM neuronal cell adhesion molecule 0.0641494
CALR calreticulin 0.0641376
CTSD cathepsin D 0.0634555
AKR1C3 aldo-keto reductase family 1, member C3 0.0611149
ANXA2 annexin A2 0.0602846
BRI3BP BRI3 binding protein 0.0574211
CLU clusterin 0.056655
AGR2 anterior gradient 2 0.056454
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0555315
BSG basigin (Ok blood group) 0.054576
TMSB10 thymosin beta 10 0.0517314
PFN1 profilin 1 0.0515032
MAP1B microtubule-associated protein 1B 0.0492965
PRRC2C proline-rich coiled-coil 2C 0.0475734
RPLP1 ribosomal protein, large, P1 0.047568
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0475306
POTEF POTE ankyrin domain family, member F 0.0474819
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 0.0473525
GLIS3 GLIS family zinc finger 3 0.0469307
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0459737
PLCH1 phospholipase C, eta 1 0.0454374
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0445319
IGF1R insulin-like growth factor 1 receptor 0.0442998
MGST1 microsomal glutathione S-transferase 1 0.0441667
RPL13A ribosomal protein L13a 0.0431585
FADS2 fatty acid desaturase 2 0.0428519
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0426933
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0425878
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0422041
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0418326
RPL18 ribosomal protein L18 0.041306
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0405457
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0401858
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.0395225
RPS19 ribosomal protein S19 0.0390426
BLTP2 bridge-like lipid transfer protein family member 2 0.0384517
RPL15 ribosomal protein L15 0.0381288
FTH1 ferritin, heavy polypeptide 1 0.037341
CCNI cyclin I 0.0371215
KRT7 keratin 7, type II 0.0360749
FLNA filamin A, alpha 0.0359533
SFTPA2 surfactant protein A2 0.0358104
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 0.0356969
MPRIP myosin phosphatase Rho interacting protein 0.035686
PDIA3 protein disulfide isomerase family A, member 3 0.035615
EIF5B eukaryotic translation initiation factor 5B 0.035541
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0337244
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0335197
DST dystonin 0.0333356
DIAPH1 diaphanous-related formin 1 0.0333197
IQGAP1 IQ motif containing GTPase activating protein 1 0.0332854
RRBP1 ribosome binding protein 1 0.0332236
PLEC plectin 0.0329958
SMAD3 SMAD family member 3 0.0327821
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 0.0327622
KTN1 kinectin 1 (kinesin receptor) 0.0323282
TKT transketolase 0.0319719
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0316361
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0313051
ACLY ATP citrate lyase 0.0311598
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0309503
ANKRD11 ankyrin repeat domain 11 0.0307574
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0305657
PTMS parathymosin 0.0304617
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0304082
VCL vinculin 0.0301059
KIF21A kinesin family member 21A 0.0299953
CCDC57 coiled-coil domain containing 57 0.029904
MLEC malectin 0.0298373
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.0298291
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0295842
COP1 COP1 E3 ubiquitin ligase 0.0294589
MUSK muscle, skeletal, receptor tyrosine kinase 0.0294564
SEPTIN9 septin 9 0.0293171
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0291272
RACK1 receptor for activated C kinase 1 0.0290179
GSTP1 glutathione S-transferase pi 1 0.028861
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0288509
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0288341
MKI67 marker of proliferation Ki-67 0.0281346
CCT3 chaperonin containing TCP1, subunit 3 (gamma) 0.0277377
PLXNB2 plexin B2 0.0274738
RPLP2 ribosomal protein, large, P2 0.0273114
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0272722
GNPDA1 glucosamine-6-phosphate deaminase 1 0.027094
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0268265
LOC112694756 uncharaterized LOC112694756 0.0267759
KRT81 keratin 81, type II 0.0266307
GTF2I general transcription factor IIi 0.0265832
ATOSA atos homolog A 0.0264846
PRPF8 pre-mRNA processing factor 8 0.0264446
CKAP4 cytoskeleton-associated protein 4 0.0263804
HSPH1 heat shock 105kDa/110kDa protein 1 0.0256543
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0255873
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0255539
ATP5F1C ATP synthase F1 subunit gamma 0.0255047
CD44 CD44 molecule (Indian blood group) 0.0254961
DHCR7 7-dehydrocholesterol reductase 0.0253159
VCAN versican 0.0251427
SLC38A1 solute carrier family 38, member 1 0.024654
NQO1 NAD(P)H dehydrogenase, quinone 1 0.024314
DSPP dentin sialophosphoprotein 0.0243097
GDI2 GDP dissociation inhibitor 2 0.0243029
RPL39 ribosomal protein L39 0.024177
LY6E lymphocyte antigen 6 complex, locus E 0.0241572
RPS5 ribosomal protein S5 0.0240716
KDM5A lysine (K)-specific demethylase 5A 0.0240645
MTREX Mtr4 exosome RNA helicase 0.0240447
OLA1 Obg-like ATPase 1 0.0239755
SENP6 SUMO1/sentrin specific peptidase 6 0.0239744
COL5A2 collagen, type V, alpha 2 0.0239024
ITGAV integrin, alpha V 0.0238147
LDHA lactate dehydrogenase A 0.0237688
RPL36 ribosomal protein L36 0.0235808
PRPF4B pre-mRNA processing factor 4B 0.0235772
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) 0.0235717
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 0.023144
CCND1 cyclin D1 0.0228656
S100A10 S100 calcium binding protein A10 0.0227995
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0227866
CENPF centromere protein F, 350/400kDa 0.0227805
CENPK centromere protein K 0.0227773
GPBP1 GC-rich promoter binding protein 1 0.0226931
MMS22L MMS22-like, DNA repair protein 0.0226803
TXN2 thioredoxin 2 0.0224835
RPS23 ribosomal protein S23 0.0224715
NLK nemo-like kinase 0.0224509
EP400 E1A binding protein p400 0.0224258
RPS21 ribosomal protein S21 0.022379
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 0.0222075
SCARB2 scavenger receptor class B, member 2 0.0219897
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0218513
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 0.0218166
LAMB1 laminin, beta 1 0.0218002
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) 0.0217631
PERP PERP, TP53 apoptosis effector 0.0216641
C19ORF12 chromosome 19 open reading frame 12 0.0215895
CD63 CD63 molecule 0.0214998
RPL23A ribosomal protein L23a 0.0213954
RPS27A ribosomal protein S27a 0.0213795
AHNAK AHNAK nucleoprotein 0.0213423
TSPAN14 tetraspanin 14 0.0210219
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0209871
UBB ubiquitin B 0.0209782
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 0.0208559
MYO10 myosin X 0.0208352
RASAL2 RAS protein activator like 2 0.0206605
SH3D19 SH3 domain containing 19 0.0205808
ATAD5 ATPase family, AAA domain containing 5 0.0205586
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.0204894
ACTG1 actin gamma 1 0.0204816
ANKRD17 ankyrin repeat domain 17 0.0204617
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0204592
TSKU tsukushi, small leucine rich proteoglycan 0.0203272
VGLL4 vestigial-like family member 4 0.0202531
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0202498
EBF1 early B-cell factor 1 0.0202482
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0200944
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0200787
LAMA4 laminin, alpha 4 0.0198672
SBF2 SET binding factor 2 0.0198553
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0198295
SMG7 SMG7 nonsense mediated mRNA decay factor 0.019707
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0196749
TUBA1B tubulin, alpha 1b 0.0196482
RPL28 ribosomal protein L28 0.0195571
SOS2 son of sevenless homolog 2 (Drosophila) 0.019512
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0194013
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.0193951
CCND3 cyclin D3 0.0193885
AKR1C1 aldo-keto reductase family 1, member C1 0.0193739
MARK2 MAP/microtubule affinity-regulating kinase 2 0.0192711
CEP290 centrosomal protein 290kDa 0.0192697
XBP1 X-box binding protein 1 0.0192309
MORF4L2 mortality factor 4 like 2 0.0191998
SSR2 signal sequence receptor, beta (translocon-associated protein beta) 0.0191515
BRCA1 breast cancer 1, early onset 0.019139
IDE insulin-degrading enzyme 0.0190841
DNM1 dynamin 1 0.0190756
MSN moesin 0.0190525
RPS14 ribosomal protein S14 0.0190431
LDAH lipid droplet associated hydrolase 0.0190186
PTRH2 peptidyl-tRNA hydrolase 2 0.0190184
IL6R interleukin 6 receptor 0.0189775
NCOA3 nuclear receptor coactivator 3 0.018906
CCT7 chaperonin containing TCP1, subunit 7 (eta) 0.018855
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 0.0187604
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.0187447
WWTR1 WW domain containing transcription regulator 1 0.0187294
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0187113
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.0186972
IGFBP7 insulin-like growth factor binding protein 7 0.0186705
TBC1D16 TBC1 domain family, member 16 0.0185842
FRAS1 Fraser extracellular matrix complex subunit 1 0.0184792
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 0.0184626
ZFYVE16 zinc finger, FYVE domain containing 16 0.0184567
TLN1 talin 1 0.0184208
MTUS1 microtubule associated tumor suppressor 1 0.0184068
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa 0.0183658
ADIPOR2 adiponectin receptor 2 0.0183612
FAM193B family with sequence similarity 193, member B 0.0183499
CTSS cathepsin S 0.0183034
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 0.018275
MAML3 mastermind-like 3 (Drosophila) 0.0182599
RPS11 ribosomal protein S11 0.0182097
RUSC2 RUN and SH3 domain containing 2 0.0181631
ERGIC3 ERGIC and golgi 3 0.0180822
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) 0.0179238
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0179067
HP1BP3 heterochromatin protein 1, binding protein 3 0.0179048
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0178805
RSL1D1 ribosomal L1 domain containing 1 0.0178738
GCC2 GRIP and coiled-coil domain containing 2 0.0178441
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0177953
ECT2 epithelial cell transforming 2 0.0177516
LARS1 leucyl-tRNA synthetase 1 0.0177105
ZFR zinc finger RNA binding protein 0.0176841
AGK acylglycerol kinase 0.017646
COX7B cytochrome c oxidase subunit VIIb 0.0176012
SH2D4A SH2 domain containing 4A 0.0175672
CPT1A carnitine palmitoyltransferase 1A (liver) 0.0175352
APLP2 amyloid beta (A4) precursor-like protein 2 0.0175178
MYADM myeloid-associated differentiation marker 0.0175037
RPL29 ribosomal protein L29 0.017483
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0173215
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0173113
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 0.0172912
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.017245
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0172409
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0172161
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 0.0171934
ANO10 anoctamin 10 0.0171709
BMS1 BMS1 ribosome biogenesis factor 0.0171224
WAPL WAPL cohesin release factor 0.0170948
MVP major vault protein 0.0170453
MRPS18B mitochondrial ribosomal protein S18B 0.0170067
RSF1 remodeling and spacing factor 1 0.0169989
RPL4 ribosomal protein L4 0.016947
SMAD6 SMAD family member 6 0.0169468
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa 0.0169445
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0169108
RNF168 ring finger protein 168, E3 ubiquitin protein ligase 0.0168953
KIF2A kinesin heavy chain member 2A 0.0168888
RPS9 ribosomal protein S9 0.0168387
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0168278
DHRS7 dehydrogenase/reductase (SDR family) member 7 0.0167967
BUB1 BUB1 mitotic checkpoint serine/threonine kinase 0.0167058
RPS12 ribosomal protein S12 0.0166355
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0166312
SMAD5 SMAD family member 5 0.0166285
NSD3 nuclear receptor binding SET domain protein 3 0.0166142
SMAGP small cell adhesion glycoprotein 0.016608
EEA1 early endosome antigen 1 0.0165767
LASP1 LIM and SH3 protein 1 0.0165446
LMBRD1 LMBR1 domain containing 1 0.016536
TACC1 transforming, acidic coiled-coil containing protein 1 0.016522
CARS1 cysteinyl-tRNA synthetase 1 0.01651
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.0165
JADE2 jade family PHD finger 2 0.0164161
PRKCSH protein kinase C substrate 80K-H 0.0164088
AFF4 AF4/FMR2 family, member 4 0.0163907
CSNK1A1 casein kinase 1, alpha 1 0.0163638
CPPED1 calcineurin-like phosphoesterase domain containing 1 0.0163432
SLC38A10 solute carrier family 38, member 10 0.0163187
TAMM41 TAM41, mitochondrial translocator assembly and maintenance protein, homolog (S. cerevisiae) 0.0163145
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0162936
AHNAK2 AHNAK nucleoprotein 2 0.0162859
ATF6 activating transcription factor 6 0.0161412
MNX1 motor neuron and pancreas homeobox 1 0.0161406
HEATR5B HEAT repeat containing 5B 0.0161383
SPOP speckle-type POZ protein 0.0161353
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 0.0161129
INHBB inhibin, beta B 0.0161112
FAM13B family with sequence similarity 13, member B 0.0161017
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa 0.0160958
FAM168A family with sequence similarity 168, member A 0.0160691
OPN3 opsin 3 0.0160373
PGP phosphoglycolate phosphatase 0.0159964
SET SET nuclear proto-oncogene 0.0159113
NR2F6 nuclear receptor subfamily 2, group F, member 6 0.0158909
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0158556
PCNT pericentrin 0.015824
CEP350 centrosomal protein 350kDa 0.0158106
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0157949
SDC1 syndecan 1 0.0157695
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 0.0157545
MCM3 minichromosome maintenance complex component 3 0.0157347
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 0.0156927
MRPS5 mitochondrial ribosomal protein S5 0.0156843
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0156802
PBX1 pre-B-cell leukemia homeobox 1 0.0156682
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 0.015601
KMT2A lysine (K)-specific methyltransferase 2A 0.0155964
SNX17 sorting nexin 17 0.015569
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0155511
NIPBL Nipped-B homolog (Drosophila) 0.0155372
KARS1 lysyl-tRNA synthetase 1 0.0154932
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0154499
WDHD1 WD repeat and HMG-box DNA binding protein 1 0.0154378
URI1 URI1, prefoldin-like chaperone 0.0153653
VARS1 valyl-tRNA synthetase 1 0.0153482
IGSF11 immunoglobulin superfamily, member 11 0.015318
RPS2 ribosomal protein S2 0.0153054
RTF2 replication termination factor 2 0.0152857
SLX4IP SLX4 interacting protein 0.0152545
FBXW4 F-box and WD repeat domain containing 4 0.01524
CBX5 chromobox homolog 5 0.015237
RO60 Ro60, Y RNA binding protein 0.0152209
TRA2B transformer 2 beta homolog (Drosophila) 0.0152187
TMEM41B transmembrane protein 41B 0.0151975
STRN4 striatin, calmodulin binding protein 4 0.0151639
NUMA1 nuclear mitotic apparatus protein 1 0.0151556
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 0.0151413
PARK7 parkinson protein 7 0.015114
ITCH itchy E3 ubiquitin protein ligase 0.0151105
SLC38A6 solute carrier family 38, member 6 0.0150855
IGF2R insulin-like growth factor 2 receptor 0.0150481
ACTN1 actinin, alpha 1 0.0150389
FAM120C family with sequence similarity 120C 0.0150326
CCNB1 cyclin B1 0.0150052
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0150045
CNOT10 CCR4-NOT transcription complex, subunit 10 0.0149875
RESF1 retroelement silencing factor 1 0.0149805
SLF1 SMC5-SMC6 complex localization factor 1 0.0149701
NUP153 nucleoporin 153kDa 0.0149392
NAV2 neuron navigator 2 0.0149361
ZC3H4 zinc finger CCCH-type containing 4 0.0149229
WDSUB1 WD repeat, sterile alpha motif and U-box domain containing 1 0.0148774
COPG2 coatomer protein complex, subunit gamma 2 0.0148504
STIM1 stromal interaction molecule 1 0.0148248
PANK3 pantothenate kinase 3 0.0148206
SMC1A structural maintenance of chromosomes 1A 0.0148199
SCYL2 SCY1-like 2 (S. cerevisiae) 0.0148132
ETV5 ets variant 5 0.0147995
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0147817
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0147596
RBM33 RNA binding motif protein 33 0.014725
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.0147094
LEPROT leptin receptor overlapping transcript 0.0146902
RSRC1 arginine/serine-rich coiled-coil 1 0.0146789
EMC10 ER membrane protein complex subunit 10 0.0146727
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0146544
CHCHD10 coiled-coil-helix-coiled-coil-helix domain containing 10 0.0146534
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0146483
COLGALT1 collagen beta(1-O)galactosyltransferase 1 0.0146174
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0145861
RPS13 ribosomal protein S13 0.0145859
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 0.0145654
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.014559
PSENEN presenilin enhancer gamma secretase subunit 0.0145271
VKORC1L1 vitamin K epoxide reductase complex, subunit 1-like 1 0.0145256
GSK3B glycogen synthase kinase 3 beta 0.0145227
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.0145013
CTSL cathepsin L 0.0144888
MYEOV myeloma overexpressed 0.0144544
NAXE NAD(P)HX epimerase 0.0144333
GOLGB1 golgin B1 0.0144118
EIF4E2 eukaryotic translation initiation factor 4E family member 2 0.0143938
SOD1 superoxide dismutase 1, soluble 0.01439
TSPAN4 tetraspanin 4 0.0143679
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0143505
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.0143476
RDX radixin 0.0143427
KIRREL3 kin of IRRE like 3 (Drosophila) 0.0143131
ARHGAP1 Rho GTPase activating protein 1 0.0142975
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12 0.0142833
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0142725
KMT2C lysine (K)-specific methyltransferase 2C 0.0142715
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 0.014267
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 0.0142536
RPL7L1 ribosomal protein L7-like 1 0.014227
DNASE2 deoxyribonuclease II, lysosomal 0.0142267
KMT2E lysine (K)-specific methyltransferase 2E 0.0142151
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.0141788
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0141755
ERBIN erbb2 interacting protein 0.0141732
KPNB1 karyopherin (importin) beta 1 0.0141571
RIPK2 receptor-interacting serine-threonine kinase 2 0.014109
BBX bobby sox homolog (Drosophila) 0.0140972
PRELID1 PRELI domain containing 1 0.0140811
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.01408
FAM168B family with sequence similarity 168, member B 0.0140719
S100A6 S100 calcium binding protein A6 0.0140218
HMGXB4 HMG box domain containing 4 0.0140202
PANK2 pantothenate kinase 2 0.0139956
DCBLD1 discoidin, CUB and LCCL domain containing 1 0.0139745
RPS17 ribosomal protein S17 0.0139682
NAAA N-acylethanolamine acid amidase 0.013956
ADNP activity-dependent neuroprotector homeobox 0.0139361
CHD4 chromodomain helicase DNA binding protein 4 0.0139044
CERT1 ceramide transporter 1 0.0138659
NUP58 nucleoporin 58 0.0138623
KIAA0586 KIAA0586 0.0138329
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0138217
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0137995
SAP130 Sin3A-associated protein, 130kDa 0.0137874
ZDHHC20 zinc finger, DHHC-type containing 20 0.0137726
MAGED1 melanoma antigen family D1 0.0137589
CDK8 cyclin-dependent kinase 8 0.0137584
OSBP oxysterol binding protein 0.0137431
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0137357
CCDC112 coiled-coil domain containing 112 0.0137274
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.0136965
EIF2A eukaryotic translation initiation factor 2A, 65kDa 0.0136828
GANAB glucosidase, alpha; neutral AB 0.013647
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 0.01359
PDGFD platelet derived growth factor D 0.0135724
DMXL2 Dmx-like 2 0.013572
BAG3 BCL2-associated athanogene 3 0.0135689
FCHO2 FCH domain only 2 0.0135338
AAGAB alpha- and gamma-adaptin binding protein 0.0135243
CDC45 cell division cycle 45 0.0135137
SCRN1 secernin 1 0.0135056
SUSD1 sushi domain containing 1 0.0134909
GNS glucosamine (N-acetyl)-6-sulfatase 0.0134648
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 0.0134304
GOLT1A golgi transport 1A 0.0134219
RPS24 ribosomal protein S24 0.013403
CALU calumenin 0.0134018
ZBED5 zinc finger, BED-type containing 5 0.0133902
L3HYPDH L-3-hydroxyproline dehydratase (trans-) 0.0133759
TPR translocated promoter region, nuclear basket protein 0.0133738
KIF23 kinesin family member 23 0.0133716
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0133703
MTCH2 mitochondrial carrier 2 0.0133551
CEP128 centrosomal protein 128kDa 0.0133461
ZHX2 zinc fingers and homeoboxes 2 0.0133437
LYN LYN proto-oncogene, Src family tyrosine kinase 0.013319
PIBF1 progesterone immunomodulatory binding factor 1 0.0132878
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0132534
TSEN2 TSEN2 tRNA splicing endonuclease subunit 0.0132336
COL4A1 collagen, type IV, alpha 1 0.01322
WDR72 WD repeat domain 72 0.0132011
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0131952
DNMBP dynamin binding protein 0.0131843
CANX calnexin 0.0131815
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0131681
CD46 CD46 molecule, complement regulatory protein 0.0131655
XPO4 exportin 4 0.0131598
ERI3 ERI1 exoribonuclease family member 3 0.0131511
PUM3 pumilio RNA binding family member 3 0.0131435
PCGF6 polycomb group ring finger 6 0.0130685
GON4L gon-4-like (C. elegans) 0.0130624
SLC30A5 solute carrier family 30 (zinc transporter), member 5 0.0130531
KLHL28 kelch-like family member 28 0.0130478
CLASP1 cytoplasmic linker associated protein 1 0.0130449
SSH2 slingshot protein phosphatase 2 0.0129985
ZNF787 zinc finger protein 787 0.0129969
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta 0.0129791
HOMER1 homer scaffolding protein 1 0.0129785
CNOT8 CCR4-NOT transcription complex, subunit 8 0.0129608
PTPRM protein tyrosine phosphatase, receptor type, M 0.0129465
SMIM14 small integral membrane protein 14 0.0129333
NBR1 neighbor of BRCA1 gene 1 0.0129188
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0129146
EIF4A1 eukaryotic translation initiation factor 4A1 0.0129118
CXXC1 CXXC finger protein 1 0.0128965
FMNL2 formin-like 2 0.0128844
TMPO thymopoietin 0.0128769
CUEDC1 CUE domain containing 1 0.0128691
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2 0.0128653
FRK fyn-related Src family tyrosine kinase 0.0128629
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0128303
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0128096
HELLS helicase, lymphoid-specific 0.0127766
GPR107 G protein-coupled receptor 107 0.0127669
TMEM164 transmembrane protein 164 0.012765
NUDC nudC nuclear distribution protein 0.0127593
FOXO1 forkhead box O1 0.0127375
ARHGAP21 Rho GTPase activating protein 21 0.0127371
CYTH1 cytohesin 1 0.0127048
SH3RF2 SH3 domain containing ring finger 2 0.012702
DTYMK deoxythymidylate kinase (thymidylate kinase) 0.0126751
YLPM1 YLP motif containing 1 0.0126708
KPNA6 karyopherin alpha 6 (importin alpha 7) 0.0126497
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.0126292
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.012623
DKC1 dyskeratosis congenita 1, dyskerin 0.0126069
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 0.0126009
TPST1 tyrosylprotein sulfotransferase 1 0.0125919
LMNB2 lamin B2 0.0125749
ATP9B ATPase, class II, type 9B 0.0125629
RBMX RNA binding motif protein, X-linked 0.0125614
ATP5F1B ATP synthase F1 subunit beta 0.0125607
PGAP2 post-GPI attachment to proteins 2 0.0125367
TEX10 testis expressed 10 0.0125307
SETD3 SET domain containing 3 0.0125307
SP3 Sp3 transcription factor 0.0125269
DOCK9 dedicator of cytokinesis 9 0.0125065

decreased expression

Symbol Name Standardized Value
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.164648
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0845989
EHBP1 EH domain binding protein 1 -0.0837874
FN1 fibronectin 1 -0.0735616
MED13L mediator complex subunit 13-like -0.0728868
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0695466
WWOX WW domain containing oxidoreductase -0.0683491
PDLIM5 PDZ and LIM domain 5 -0.0636239
THSD7A thrombospondin, type I, domain containing 7A -0.0599197
BCAS3 breast carcinoma amplified sequence 3 -0.0574733
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0573145
ARHGAP26 Rho GTPase activating protein 26 -0.0563942
ATE1 arginyltransferase 1 -0.0560638
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0539569
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0539046
MYO1E myosin IE -0.0535171
TBC1D5 TBC1 domain family, member 5 -0.0532093
BIRC6 baculoviral IAP repeat containing 6 -0.0529559
DAPK1 death-associated protein kinase 1 -0.0527807
ZBTB20 zinc finger and BTB domain containing 20 -0.0519328
STX8 syntaxin 8 -0.0515192
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0514805
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0506298
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0498736
GPC6 glypican 6 -0.0493301
DIAPH2 diaphanous-related formin 2 -0.0480063
CLIP2 CAP-GLY domain containing linker protein 2 -0.0473944
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0467119
PDE8A phosphodiesterase 8A -0.0463348
FRMD3 FERM domain containing 3 -0.0458754
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0458663
GRAMD1B GRAM domain containing 1B -0.0457733
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.0452124
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.045078
CSNK2A2 casein kinase 2, alpha prime polypeptide -0.0448647
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0437506
USP32 ubiquitin specific peptidase 32 -0.0436276
TTC28 tetratricopeptide repeat domain 28 -0.043582
VMP1 vacuole membrane protein 1 -0.0425027
USP9X ubiquitin specific peptidase 9, X-linked -0.0423777
EFNA5 ephrin-A5 -0.0422065
THSD4 thrombospondin, type I, domain containing 4 -0.0416888
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0411696
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.0407376
GCLC glutamate-cysteine ligase, catalytic subunit -0.0404974
APP amyloid beta (A4) precursor protein -0.0392912
RABGAP1L RAB GTPase activating protein 1-like -0.0388794
TRIO trio Rho guanine nucleotide exchange factor -0.0388788
GPATCH8 G patch domain containing 8 -0.0385874
MED13 mediator complex subunit 13 -0.038474
ADAM17 ADAM metallopeptidase domain 17 -0.0381804
PTGR1 prostaglandin reductase 1 -0.0378446
NFIB nuclear factor I/B -0.0371886
JMJD1C jumonji domain containing 1C -0.0369164
CNTNAP3B contactin associated protein-like 3B -0.0368966
ETFA electron-transfer-flavoprotein, alpha polypeptide -0.0368575
PARD3 par-3 family cell polarity regulator -0.0366733
LRMDA leucine rich melanocyte differentiation associated -0.0366577
MEGF9 multiple EGF-like-domains 9 -0.035769
EML4 echinoderm microtubule associated protein like 4 -0.0356114
PICALM phosphatidylinositol binding clathrin assembly protein -0.0346089
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 -0.034503
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0341082
TET3 tet methylcytosine dioxygenase 3 -0.0340486
TCF12 transcription factor 12 -0.0340239
CP ceruloplasmin (ferroxidase) -0.0338672
CUX1 cut-like homeobox 1 -0.0338232
ARL15 ADP-ribosylation factor-like 15 -0.033715
AKAP12 A kinase (PRKA) anchor protein 12 -0.0337054
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) -0.0332946
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.033254
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.032939
SLC39A11 solute carrier family 39, member 11 -0.0328511
TMC5 transmembrane channel-like 5 -0.0325888
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0325096
RAP1GAP2 RAP1 GTPase activating protein 2 -0.0323012
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0321803
RBM39 RNA binding motif protein 39 -0.032108
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0319811
NCEH1 neutral cholesterol ester hydrolase 1 -0.0319275
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0318966
GOLM2 golgi membrane protein 2 -0.0317583
PCDH9 protocadherin 9 -0.0316611
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0315661
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 -0.0314214
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0313073
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0311551
PDS5A PDS5 cohesin associated factor A -0.0309833
EXOC6B exocyst complex component 6B -0.0309376
FHIT fragile histidine triad -0.0309208
ZMYM2 zinc finger, MYM-type 2 -0.030857
TXNRD1 thioredoxin reductase 1 -0.0307118
KMT5B lysine methyltransferase 5B -0.030666
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0305217
MRTFA myocardin related transcription factor A -0.0305016
ZFP36L2 ZFP36 ring finger protein-like 2 -0.0300825
PPHLN1 periphilin 1 -0.0300714
HDAC8 histone deacetylase 8 -0.0300383
THADA thyroid adenoma associated -0.0298547
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0298281
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0293979
DOCK5 dedicator of cytokinesis 5 -0.0291249
ASPH aspartate beta-hydroxylase -0.0290884
C5 complement component 5 -0.0290661
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0289621
TMCC1 transmembrane and coiled-coil domain family 1 -0.0288054
FAF1 Fas (TNFRSF6) associated factor 1 -0.0287553
LPP LIM domain containing preferred translocation partner in lipoma -0.0287201
DNAAF9 dynein axonemal assembly factor 9 -0.0287191
AVPI1 arginine vasopressin-induced 1 -0.0287074
R3HDM2 R3H domain containing 2 -0.0285857
IGFBP3 insulin-like growth factor binding protein 3 -0.0283035
TTLL10 tubulin tyrosine ligase-like family member 10 -0.028093
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0280372
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) -0.0280222
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0277172
ARID4B AT rich interactive domain 4B (RBP1-like) -0.02752
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0275099
ARHGAP12 Rho GTPase activating protein 12 -0.0272666
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -0.0271799
PLD3 phospholipase D family, member 3 -0.0270978
SNX29 sorting nexin 29 -0.0270436
CYRIB CYFIP related Rac1 interactor B -0.027034
GMDS GDP-mannose 4,6-dehydratase -0.0269969
DIS3L2 DIS3 like 3'-5' exoribonuclease 2 -0.0269237
HIP1 huntingtin interacting protein 1 -0.0268691
ABHD3 abhydrolase domain containing 3 -0.0268236
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein -0.0267897
AKAP13 A kinase (PRKA) anchor protein 13 -0.0267141
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0264699
BMPR1B bone morphogenetic protein receptor, type IB -0.0264374
MICU1 mitochondrial calcium uptake 1 -0.0263224
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0263047
ZBTB1 zinc finger and BTB domain containing 1 -0.0260706
UBAP2 ubiquitin associated protein 2 -0.0260687
METTL16 methyltransferase like 16 -0.0258803
ENSA endosulfine alpha -0.0258707
PM20D1 peptidase M20 domain containing 1 -0.0258616
SH3PXD2A SH3 and PX domains 2A -0.0258211
SINHCAF SIN3-HDAC complex associated factor -0.0257532
FBXL17 F-box and leucine-rich repeat protein 17 -0.025685
YIPF4 Yip1 domain family, member 4 -0.0256279
PDE7A phosphodiesterase 7A -0.025617
GNAS GNAS complex locus -0.0255698
ATG7 autophagy related 7 -0.0255662
TOM1L2 target of myb1-like 2 (chicken) -0.0254922
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0253797
LUC7L LUC7-like (S. cerevisiae) -0.0253218
RRAS2 related RAS viral (r-ras) oncogene homolog 2 -0.0252936
GPR39 G protein-coupled receptor 39 -0.0252524
SLTM SAFB-like, transcription modulator -0.0251718
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0251403
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0250847
AHI1 Abelson helper integration site 1 -0.0250717
USP53 ubiquitin specific peptidase 53 -0.0248523
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 -0.0248311
CEP95 centrosomal protein 95kDa -0.0247172
FAF2 Fas associated factor family member 2 -0.0247056
PUM1 pumilio RNA-binding family member 1 -0.0246932
PTK2 protein tyrosine kinase 2 -0.0245205
GRAMD1A GRAM domain containing 1A -0.0245195
DCAF7 DDB1 and CUL4 associated factor 7 -0.0243878
KSR1 kinase suppressor of ras 1 -0.0243758
NEO1 neogenin 1 -0.024009
KDM3B lysine (K)-specific demethylase 3B -0.0236579
FBXW11 F-box and WD repeat domain containing 11 -0.0236572
FILIP1 filamin A interacting protein 1 -0.0235577
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0235294
SIK3 SIK family kinase 3 -0.0235246
BASP1 brain abundant, membrane attached signal protein 1 -0.0235128
FNBP4 formin binding protein 4 -0.0234515
XPO1 exportin 1 -0.0233236
MYO1D myosin ID -0.0233159
ILKAP integrin-linked kinase-associated serine/threonine phosphatase -0.0233056
KDM6A lysine (K)-specific demethylase 6A -0.0232461
RBPMS RNA binding protein with multiple splicing -0.0232094
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0231089
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0231047
RAD51B RAD51 paralog B -0.0230834
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 -0.0230381
LRIF1 ligand dependent nuclear receptor interacting factor 1 -0.0229996
UNK unkempt family zinc finger -0.0229813
RNF216 ring finger protein 216 -0.0228697
SYNJ2 synaptojanin 2 -0.0227548
PHACTR2 phosphatase and actin regulator 2 -0.0227125
UBE3C ubiquitin protein ligase E3C -0.0227
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0226991
ZBTB35 zinc finger and BTB domain containing 35 -0.0226248
PPP1R21 protein phosphatase 1, regulatory subunit 21 -0.0225412
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0225255
NEK9 NIMA-related kinase 9 -0.0225122
STRN3 striatin, calmodulin binding protein 3 -0.0225083
KANK1 KN motif and ankyrin repeat domains 1 -0.0224559
TGFBR3 transforming growth factor, beta receptor III -0.0223632
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0222649
NBEA neurobeachin -0.0222427
ZNF207 zinc finger protein 207 -0.0221644
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -0.0220741
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.022038
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0220156
BICDL1 BICD family like cargo adaptor 1 -0.0219772
JPT1 Jupiter microtubule associated homolog 1 -0.021931
TASOR2 transcription activation suppressor family member 2 -0.0218289
PLCB4 phospholipase C, beta 4 -0.0217687
ELL2 elongation factor, RNA polymerase II, 2 -0.0217477
UNC13B unc-13 homolog B (C. elegans) -0.0217454
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0217346
CEP112 centrosomal protein 112kDa -0.0217261
BRWD3 bromodomain and WD repeat domain containing 3 -0.0217052
WDR43 WD repeat domain 43 -0.0216941
EFTUD2 elongation factor Tu GTP binding domain containing 2 -0.0216632
NOP56 NOP56 ribonucleoprotein -0.0216494
TNRC6B trinucleotide repeat containing 6B -0.0216307
CDK19 cyclin-dependent kinase 19 -0.0215988
CLINT1 clathrin interactor 1 -0.0215506
ACYP2 acylphosphatase 2, muscle type -0.0215479
SLC25A43 solute carrier family 25, member 43 -0.0215455
YAP1 Yes-associated protein 1 -0.0215374
AHCYL2 adenosylhomocysteinase-like 2 -0.0214869
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0214389
ARHGAP5 Rho GTPase activating protein 5 -0.0213269
LITAF lipopolysaccharide-induced TNF factor -0.0213243
CCDC91 coiled-coil domain containing 91 -0.0212099
KIAA0319 KIAA0319 -0.021143
PRKCA protein kinase C, alpha -0.0211304
CNKSR3 CNKSR family member 3 -0.0211057
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0210926
ITGB5 integrin, beta 5 -0.0210882
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0210726
CLASP2 cytoplasmic linker associated protein 2 -0.0209378
EVA1C eva-1 homolog C (C. elegans) -0.0209323
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0209289
AVL9 AVL9 homolog (S. cerevisiase) -0.0209103
DGKD diacylglycerol kinase, delta 130kDa -0.0208665
NUMB numb homolog (Drosophila) -0.0208276
CREB1 cAMP responsive element binding protein 1 -0.020827
COL27A1 collagen, type XXVII, alpha 1 -0.0208239
CREBBP CREB binding protein -0.0207703
CCDC92 coiled-coil domain containing 92 -0.0207374
FER fer (fps/fes related) tyrosine kinase -0.0207001
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) -0.0206741
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0206643
CNOT6 CCR4-NOT transcription complex, subunit 6 -0.0205649
AQR aquarius intron-binding spliceosomal factor -0.0205399
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -0.0204413
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0204403
PCNX4 pecanex 4 -0.0204332
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.020399
BMPR1A bone morphogenetic protein receptor, type IA -0.0203613
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0203298
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0202796
ZNF146 zinc finger protein 146 -0.0202574
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -0.0202344
CSNK1D casein kinase 1, delta -0.0201953
PEAK1 pseudopodium-enriched atypical kinase 1 -0.020059
GSPT1 G1 to S phase transition 1 -0.0200198
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0200018
TMEM65 transmembrane protein 65 -0.0199819
HIPK2 homeodomain interacting protein kinase 2 -0.0199458
NSD1 nuclear receptor binding SET domain protein 1 -0.0198787
TMEM87A transmembrane protein 87A -0.0198668
AHCYL1 adenosylhomocysteinase-like 1 -0.0198366
UGDH UDP-glucose 6-dehydrogenase -0.0198324
MPZL1 myelin protein zero-like 1 -0.0197837
DDB2 damage-specific DNA binding protein 2, 48kDa -0.0197639
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0197111
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0196358
ZFAND6 zinc finger, AN1-type domain 6 -0.0196283
TBL1X transducin (beta)-like 1X-linked -0.0195887
PIGL phosphatidylinositol glycan anchor biosynthesis, class L -0.0195395
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0195294
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -0.0195092
PROCR protein C receptor, endothelial -0.0195029
RIC8B RIC8 guanine nucleotide exchange factor B -0.0194271
RBM10 RNA binding motif protein 10 -0.0193674
CUL1 cullin 1 -0.0193493
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 -0.0192617
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0192534
TUBD1 tubulin, delta 1 -0.0192406
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A -0.0192129
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0191743
NCOR1 nuclear receptor corepressor 1 -0.0191688
EIF4B eukaryotic translation initiation factor 4B -0.019167
IQSEC2 IQ motif and Sec7 domain 2 -0.0191186
SMC3 structural maintenance of chromosomes 3 -0.0191172
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 -0.0191167
RIN2 Ras and Rab interactor 2 -0.0191151
TBX18 T-box 18 -0.0191149
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0190724
KATNBL1 katanin p80 subunit B-like 1 -0.0190453
MRPL13 mitochondrial ribosomal protein L13 -0.0190226
VCP valosin containing protein -0.0189804
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0189514
RARS1 arginyl-tRNA synthetase 1 -0.0189413
RIOK3 RIO kinase 3 -0.0189018
SLC44A1 solute carrier family 44 (choline transporter), member 1 -0.0187891
GSR glutathione reductase -0.0187626
AOPEP aminopeptidase O (putative) -0.0187586
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0187162
RPH3AL rabphilin 3A-like (without C2 domains) -0.0186675
CDCA2 cell division cycle associated 2 -0.0186652
INTS9 integrator complex subunit 9 -0.0186444
TUT4 terminal uridylyl transferase 4 -0.0186229
PLCE1 phospholipase C, epsilon 1 -0.0186018
CUL5 cullin 5 -0.0185647
SRPK1 SRSF protein kinase 1 -0.0185509
CLPTM1 cleft lip and palate associated transmembrane protein 1 -0.0185402
TOP6BL TOP6B like initiator of meiotic double strand breaks -0.0185298
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 -0.0184828
DENND4A DENN/MADD domain containing 4A -0.0184819
SHLD1 shieldin complex subunit 1 -0.018478
TULP4 tubby like protein 4 -0.018454
ATXN3 ataxin 3 -0.0184368
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0184289
TCF20 transcription factor 20 (AR1) -0.0183851
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0183679
PPIA peptidylprolyl isomerase A (cyclophilin A) -0.018364
BCL7C B-cell CLL/lymphoma 7C -0.0183132
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0182973
HNF1A HNF1 homeobox A -0.0182634
NHSL1 NHS-like 1 -0.0182533
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0182402
SREBF2 sterol regulatory element binding transcription factor 2 -0.0182135
USPL1 ubiquitin specific peptidase like 1 -0.0181284
KYNU kynureninase -0.0180928
CTPS2 CTP synthase 2 -0.017997
MAP2K1 mitogen-activated protein kinase kinase 1 -0.0179906
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) -0.0179253
CDC42SE2 CDC42 small effector 2 -0.0179161
FBXO17 F-box protein 17 -0.0179128
CEMIP2 cell migration inducing hyaluronidase 2 -0.0179009
RNF145 ring finger protein 145 -0.0178696
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0178143
AUTS2 autism susceptibility candidate 2 -0.0178112
NTN4 netrin 4 -0.0178055
EHMT1 euchromatic histone-lysine N-methyltransferase 1 -0.0177995
MUC13 mucin 13, cell surface associated -0.0177934
HNRNPF heterogeneous nuclear ribonucleoprotein F -0.0177764
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin -0.0177744
NFX1 nuclear transcription factor, X-box binding 1 -0.0177631
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor -0.0177552
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.0177448
CDK13 cyclin-dependent kinase 13 -0.0176734
ARHGAP42 Rho GTPase activating protein 42 -0.0175774
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0175722
VDAC2 voltage-dependent anion channel 2 -0.0175505
AUH AU RNA binding protein/enoyl-CoA hydratase -0.0175422
ARHGAP10 Rho GTPase activating protein 10 -0.0174932
SMC6 structural maintenance of chromosomes 6 -0.0174355
LMTK2 lemur tyrosine kinase 2 -0.0173874
STYXL1 serine/threonine/tyrosine interacting-like 1 -0.0173867
TBCA tubulin folding cofactor A -0.0173726
ZMYND8 zinc finger, MYND-type containing 8 -0.0173684
CCNYL1 cyclin Y-like 1 -0.0173236
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5 -0.0173219
FNDC3B fibronectin type III domain containing 3B -0.0173128
ZC3H18 zinc finger CCCH-type containing 18 -0.0173122
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 -0.0173076
MYO5C myosin VC -0.0172888
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0172556
JAK1 Janus kinase 1 -0.017202
SMAD2 SMAD family member 2 -0.0171965
TRIM37 tripartite motif containing 37 -0.0171612
DCTN1 dynactin 1 -0.0171425
SND1 staphylococcal nuclease and tudor domain containing 1 -0.017056
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) -0.0169902
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -0.0169844
CTBP2 C-terminal binding protein 2 -0.0169613
ZNF652 zinc finger protein 652 -0.0169604
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0169518
FOSL1 FOS-like antigen 1 -0.0168887
LONP2 lon peptidase 2, peroxisomal -0.0168804
UQCRC2 ubiquinol-cytochrome c reductase core protein II -0.0168674
MYOF myoferlin -0.0168613
USP48 ubiquitin specific peptidase 48 -0.0168551
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0168463
GATAD2A GATA zinc finger domain containing 2A -0.0168323
FNDC3A fibronectin type III domain containing 3A -0.0167533
TOP2B topoisomerase (DNA) II beta 180kDa -0.0167351
MAP2K4 mitogen-activated protein kinase kinase 4 -0.016721
KIAA1549 KIAA1549 -0.0167169
ARHGAP24 Rho GTPase activating protein 24 -0.0166888
IER5L immediate early response 5-like -0.016616
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 -0.0166149
EXOC6 exocyst complex component 6 -0.016604
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 -0.0165697
SLC35F3 solute carrier family 35, member F3 -0.0165319
WWP2 WW domain containing E3 ubiquitin protein ligase 2 -0.0165134
ASXL1 additional sex combs like transcriptional regulator 1 -0.0164872
LPCAT3 lysophosphatidylcholine acyltransferase 3 -0.0164601
INVS inversin -0.0164158
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 -0.0163389
LGSN lengsin, lens protein with glutamine synthetase domain -0.016335
ARHGAP11B Rho GTPase activating protein 11B -0.0162978
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0162283
SLC35D4 solute carrier family 35 member D4 -0.0162275
ETF1 eukaryotic translation termination factor 1 -0.0162266
ZNF121 zinc finger protein 121 -0.0162194
ARRB1 arrestin, beta 1 -0.0161997
GDNF glial cell derived neurotrophic factor -0.0161188
PTPRA protein tyrosine phosphatase, receptor type, A -0.0161096
MED29 mediator complex subunit 29 -0.0161084
WSB1 WD repeat and SOCS box containing 1 -0.0160979
CEP126 centrosomal protein 126kDa -0.0160936
TAOK3 TAO kinase 3 -0.016091
AXL AXL receptor tyrosine kinase -0.0160651
SETBP1 SET binding protein 1 -0.0160297
ARID1A AT rich interactive domain 1A (SWI-like) -0.0160166
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0159894
SDCCAG8 serologically defined colon cancer antigen 8 -0.0159825
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) -0.0159811
SRFBP1 serum response factor binding protein 1 -0.0159687
VIM vimentin -0.0159283
FOXN2 forkhead box N2 -0.0159259
SPIDR scaffolding protein involved in DNA repair -0.0159198
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0159056
SETDB1 SET domain, bifurcated 1 -0.0158603
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0158256
RASA2 RAS p21 protein activator 2 -0.0158181
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0158125
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 -0.0157988
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 -0.015749
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0156826
LRRC58 leucine rich repeat containing 58 -0.0156215
USO1 USO1 vesicle transport factor -0.015616
FOXK2 forkhead box K2 -0.0155919
SIRT1 sirtuin 1 -0.0155704
TMEM117 transmembrane protein 117 -0.0155592
FOXN3 forkhead box N3 -0.0155581
RILPL1 Rab interacting lysosomal protein-like 1 -0.015544
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa -0.0155366
PDE4D phosphodiesterase 4D, cAMP-specific -0.0155306
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 -0.0155258
KCNT2 potassium channel, sodium activated subfamily T, member 2 -0.0154541
RCOR3 REST corepressor 3 -0.0154047
MYO9A myosin IXA -0.0153948
DPY19L3 dpy-19-like 3 (C. elegans) -0.0153879
EXOC2 exocyst complex component 2 -0.0153752
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.015355
SPPL2A signal peptide peptidase like 2A -0.0153459
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 -0.0153444
SCAPER S-phase cyclin A-associated protein in the ER -0.0153218
HSCB HscB mitochondrial iron-sulfur cluster co-chaperone -0.0152923
UBN2 ubinuclein 2 -0.0152281
NOSTRIN nitric oxide synthase trafficking -0.0152263
ANKRD44 ankyrin repeat domain 44 -0.0151824
NDRG1 N-myc downstream regulated 1 -0.0151556
MPHOSPH9 M-phase phosphoprotein 9 -0.0150995
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 -0.0150376
GTF2IRD2B GTF2I repeat domain containing 2B -0.015002
PHPT1 phosphohistidine phosphatase 1 -0.0150006
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0149916
SATB2 SATB homeobox 2 -0.0149823
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0149603
CORO2A coronin, actin binding protein, 2A -0.0148772
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -0.0148665
C5ORF24 chromosome 5 open reading frame 24 -0.0148066
ULK2 unc-51 like autophagy activating kinase 2 -0.0148049
SETD5 SET domain containing 5 -0.0148014
PIGU phosphatidylinositol glycan anchor biosynthesis, class U -0.0147998
RPS18 ribosomal protein S18 -0.014789
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34 -0.0147735
LIN52 lin-52 DREAM MuvB core complex component -0.0147702
CCDC14 coiled-coil domain containing 14 -0.0147648
ANXA7 annexin A7 -0.0147581
NAP1L1 nucleosome assembly protein 1-like 1 -0.0147334
ZNF609 zinc finger protein 609 -0.0147328
ACBD6 acyl-CoA binding domain containing 6 -0.0146964
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) -0.014673
UBE2H ubiquitin-conjugating enzyme E2H -0.0146604
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0146557
TRMT10B tRNA methyltransferase 10 homolog B (S. cerevisiae) -0.0146555
CERS6 ceramide synthase 6 -0.0146396
FAM219A family with sequence similarity 219, member A -0.0146391
CAPNS1 calpain, small subunit 1 -0.0146364
TNPO1 transportin 1 -0.0145969
PHYKPL 5-phosphohydroxy-L-lysine phospho-lyase -0.0145635
WRN Werner syndrome, RecQ helicase-like -0.0145629
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 -0.0145611
MESD mesoderm development LRP chaperone -0.0145573
NCOA2 nuclear receptor coactivator 2 -0.014548
SOGA1 suppressor of glucose, autophagy associated 1 -0.014537
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0145332
NAA20 N(alpha)-acetyltransferase 20, NatB catalytic subunit -0.0145248
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0145204
THRB thyroid hormone receptor, beta -0.0145058
FYCO1 FYVE and coiled-coil domain containing 1 -0.0145057
MACROD2 MACRO domain containing 2 -0.0145
MLH1 mutL homolog 1 -0.0144774
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme -0.014463
NIBAN2 niban apoptosis regulator 2 -0.0144342
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0143914
PPARG peroxisome proliferator-activated receptor gamma -0.0143857
TGIF1 TGFB-induced factor homeobox 1 -0.014357
TULP3 tubby like protein 3 -0.0143559
PDE7B phosphodiesterase 7B -0.0143481
MACO1 macoilin 1 -0.0143212
FBXL20 F-box and leucine-rich repeat protein 20 -0.0143185
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0142866
AARS1 alanyl-tRNA synthetase 1 -0.0142706