A549_NVP-BSK805 2HCl_10µM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description NVP-BSK805 2HCl 10µM perturbation in A549 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the A549_NVP-BSK805 2HCl_10µM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.321713
MUSK muscle, skeletal, receptor tyrosine kinase 0.239709
FTL ferritin, light polypeptide 0.215373
SQSTM1 sequestosome 1 0.170255
CA12 carbonic anhydrase XII 0.122615
KRT81 keratin 81, type II 0.0968567
AKR1C2 aldo-keto reductase family 1, member C2 0.0953994
FADS2 fatty acid desaturase 2 0.0946451
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.0810204
UBL4A ubiquitin-like 4A 0.0804656
DHCR7 7-dehydrocholesterol reductase 0.0733364
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0730693
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0714192
FTH1 ferritin, heavy polypeptide 1 0.0701625
RPLP1 ribosomal protein, large, P1 0.0696639
CTSD cathepsin D 0.0687313
CLU clusterin 0.0635394
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.0607591
SQLE squalene epoxidase 0.0603214
FASN fatty acid synthase 0.0569579
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.056947
ANKRD11 ankyrin repeat domain 11 0.0558059
MAP1B microtubule-associated protein 1B 0.0550744
RPS2 ribosomal protein S2 0.0545733
ENO1 enolase 1, (alpha) 0.0516879
PHGDH phosphoglycerate dehydrogenase 0.0515769
ELOVL6 ELOVL fatty acid elongase 6 0.0510512
PKM pyruvate kinase, muscle 0.050587
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0497002
TKT transketolase 0.0493531
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0474804
AKR1C1 aldo-keto reductase family 1, member C1 0.0466311
AKR1C3 aldo-keto reductase family 1, member C3 0.0452644
PCDHB16 protocadherin beta 16 0.0445679
TXNRD1 thioredoxin reductase 1 0.0420387
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0415829
GCLM glutamate-cysteine ligase, modifier subunit 0.0408778
RPL13A ribosomal protein L13a 0.0408574
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.0397931
RPS6 ribosomal protein S6 0.0395419
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0392778
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0387222
LOC112694756 uncharaterized LOC112694756 0.0383001
ABTB3 ankyrin repeat and BTB domain containing 3 0.0376402
CXXC1 CXXC finger protein 1 0.037454
CLIP1 CAP-GLY domain containing linker protein 1 0.0366459
RPS16 ribosomal protein S16 0.0363885
FDPS farnesyl diphosphate synthase 0.0359384
CALR calreticulin 0.0353195
CLTC clathrin, heavy chain (Hc) 0.0347428
RPL15 ribosomal protein L15 0.03412
RPS19 ribosomal protein S19 0.0336711
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.0331832
GCLC glutamate-cysteine ligase, catalytic subunit 0.0321738
CYB5B cytochrome b5 type B (outer mitochondrial membrane) 0.0320539
KRT19 keratin 19, type I 0.0318453
SFTPA2 surfactant protein A2 0.0316404
THSD7A thrombospondin, type I, domain containing 7A 0.0314447
SLC38A1 solute carrier family 38, member 1 0.0311084
ACACA acetyl-CoA carboxylase alpha 0.0309612
TRAM1 translocation associated membrane protein 1 0.0308538
KRT8 keratin 8, type II 0.0304179
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0303405
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 0.0300205
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 0.0299479
RPLP0 ribosomal protein, large, P0 0.0295173
AHNAK2 AHNAK nucleoprotein 2 0.0293462
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0289915
CENPP centromere protein P 0.0287467
RAB10 RAB10, member RAS oncogene family 0.0284857
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 0.0282469
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.0281003
RPL30 ribosomal protein L30 0.0278354
INSIG1 insulin induced gene 1 0.0277823
RPS5 ribosomal protein S5 0.0275889
LDHB lactate dehydrogenase B 0.0273743
RPS3 ribosomal protein S3 0.0273527
NRIP1 nuclear receptor interacting protein 1 0.0268677
S100A6 S100 calcium binding protein A6 0.0263505
LRP10 low density lipoprotein receptor-related protein 10 0.0263301
LPP LIM domain containing preferred translocation partner in lipoma 0.0261319
DST dystonin 0.0260461
KRT7 keratin 7, type II 0.0258328
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0258037
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 0.0257713
MRPL13 mitochondrial ribosomal protein L13 0.0250155
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0249694
BPTF bromodomain PHD finger transcription factor 0.0248121
RFX7 regulatory factor X, 7 0.0248055
PRRC2C proline-rich coiled-coil 2C 0.0246933
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 0.0244502
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0243363
TPI1 triosephosphate isomerase 1 0.0240953
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 0.0240209
GSTP1 glutathione S-transferase pi 1 0.0234705
PRXL2A peroxiredoxin like 2A 0.0233566
RPL18 ribosomal protein L18 0.0232053
CALD1 caldesmon 1 0.0230903
EPB41 erythrocyte membrane protein band 4.1 0.0229464
KLHL5 kelch-like family member 5 0.0229091
LRP6 low density lipoprotein receptor-related protein 6 0.0228848
PLEC plectin 0.0227285
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0225805
MVD mevalonate (diphospho) decarboxylase 0.0225131
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.022389
RPS29 ribosomal protein S29 0.0221793
AREG amphiregulin 0.0221384
FLNA filamin A, alpha 0.0221036
ZFP36L2 ZFP36 ring finger protein-like 2 0.0219809
TSKU tsukushi, small leucine rich proteoglycan 0.0219285
ZBTB38 zinc finger and BTB domain containing 38 0.0219222
MYO9A myosin IXA 0.021778
RPS8 ribosomal protein S8 0.0217404
KPNB1 karyopherin (importin) beta 1 0.0217366
RPL28 ribosomal protein L28 0.0215651
AFTPH aftiphilin 0.0215578
RORA RAR-related orphan receptor A 0.0214778
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0214633
KANTR KDM5C adjacent non-coding transcript 0.0213978
SLTM SAFB-like, transcription modulator 0.0213258
BRI3BP BRI3 binding protein 0.021212
DHCR24 24-dehydrocholesterol reductase 0.0211698
INHBB inhibin, beta B 0.0209312
RNF103-CHMP3 RNF103-CHMP3 readthrough 0.0207693
ACSS2 acyl-CoA synthetase short-chain family member 2 0.020518
RPL35 ribosomal protein L35 0.0202891
RNF149 ring finger protein 149 0.0202162
FLNB filamin B, beta 0.0201879
RPS9 ribosomal protein S9 0.0201675
UBB ubiquitin B 0.0201453
NPEPPS aminopeptidase puromycin sensitive 0.0200734
MRPS34 mitochondrial ribosomal protein S34 0.0197764
EPB41L4A erythrocyte membrane protein band 4.1 like 4A 0.0197638
DSPP dentin sialophosphoprotein 0.0197212
ZEB1 zinc finger E-box binding homeobox 1 0.0197147
CD63 CD63 molecule 0.0197097
ASXL2 additional sex combs like transcriptional regulator 2 0.0196326
ZDHHC9 zinc finger, DHHC-type containing 9 0.0195123
GPX2 glutathione peroxidase 2 0.0194469
RPL32 ribosomal protein L32 0.019421
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0193815
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 0.0193672
RPL7 ribosomal protein L7 0.0192817
PSEN1 presenilin 1 0.0191952
BRCA1 breast cancer 1, early onset 0.0190911
NPC2 Niemann-Pick disease, type C2 0.0190821
CLCN7 chloride channel, voltage-sensitive 7 0.0190098
TMEM97 transmembrane protein 97 0.0189301
UBTF upstream binding transcription factor, RNA polymerase I 0.0188992
SOX9 SRY (sex determining region Y)-box 9 0.0188951
UBE2H ubiquitin-conjugating enzyme E2H 0.0188004
RPL3 ribosomal protein L3 0.018799
TSC1 tuberous sclerosis 1 0.0187698
NARS1 asparaginyl-tRNA synthetase 1 0.0186356
IGF2R insulin-like growth factor 2 receptor 0.0185935
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0185661
LPIN1 lipin 1 0.0185397
HEXA hexosaminidase A (alpha polypeptide) 0.0185349
PLS3 plastin 3 0.0184516
FAT1 FAT atypical cadherin 1 0.0183543
KMT2A lysine (K)-specific methyltransferase 2A 0.0183222
SYT1 synaptotagmin I 0.0183028
RACK1 receptor for activated C kinase 1 0.0181342
SOAT2 sterol O-acyltransferase 2 0.0180515
HSPB1 heat shock 27kDa protein 1 0.0178474
SREBF2 sterol regulatory element binding transcription factor 2 0.0178443
UTRN utrophin 0.0177586
FLVCR1 feline leukemia virus subgroup C cellular receptor 1 0.0177242
TXN2 thioredoxin 2 0.0176581
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0176422
PARD3 par-3 family cell polarity regulator 0.0173908
EXOC4 exocyst complex component 4 0.0173793
DPY19L1 dpy-19-like 1 (C. elegans) 0.0173382
KATNBL1 katanin p80 subunit B-like 1 0.0173145
NAP1L1 nucleosome assembly protein 1-like 1 0.0172918
LMNA lamin A/C 0.0172091
LDLR low density lipoprotein receptor 0.0171676
MKI67 marker of proliferation Ki-67 0.017102
EXOSC6 exosome component 6 0.0170333
LRIF1 ligand dependent nuclear receptor interacting factor 1 0.0169934
ESYT2 extended synaptotagmin-like protein 2 0.0169847
CDR2 cerebellar degeneration-related protein 2, 62kDa 0.0169802
EEF2 eukaryotic translation elongation factor 2 0.0169713
MBTPS1 membrane-bound transcription factor peptidase, site 1 0.016921
JADE2 jade family PHD finger 2 0.0167695
MLXIP MLX interacting protein 0.0167207
SKIC3 SKI3 subunit of superkiller complex 0.0167142
LCOR ligand dependent nuclear receptor corepressor 0.0166361
RPL23 ribosomal protein L23 0.0166188
SNRPA small nuclear ribonucleoprotein polypeptide A 0.0165874
NUCB1 nucleobindin 1 0.0165371
RPS27A ribosomal protein S27a 0.0163543
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0163367
FOXRED2 FAD-dependent oxidoreductase domain containing 2 0.0163232
PHF14 PHD finger protein 14 0.0162999
PFN1 profilin 1 0.0162881
LMBR1 limb development membrane protein 1 0.0162622
SEPHS2 selenophosphate synthetase 2 0.0160435
CD59 CD59 molecule, complement regulatory protein 0.0160227
ECI1 enoyl-CoA delta isomerase 1 0.0160183
RPL27A ribosomal protein L27a 0.0160038
GSR glutathione reductase 0.0159662
CHD4 chromodomain helicase DNA binding protein 4 0.0159489
HCFC1 host cell factor C1 0.0159338
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0159255
PDLIM5 PDZ and LIM domain 5 0.0159015
CBR1 carbonyl reductase 1 0.0157736
PICALM phosphatidylinositol binding clathrin assembly protein 0.0156867
MLPH melanophilin 0.0156702
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0156179
TMEM156 transmembrane protein 156 0.0154714
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0154538
UVRAG UV radiation resistance associated 0.0153933
TRIB3 tribbles pseudokinase 3 0.0153672
NRF1 nuclear respiratory factor 1 0.0152758
RPL12 ribosomal protein L12 0.0152426
RPL7A ribosomal protein L7a 0.0152408
PTMS parathymosin 0.0151586
RPL4 ribosomal protein L4 0.0151244
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0151167
TLN1 talin 1 0.0150744
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.0150335
UQCRC2 ubiquinol-cytochrome c reductase core protein II 0.0149503
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 0.0149122
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.0148969
RPS14 ribosomal protein S14 0.0148883
PRSS23 protease, serine, 23 0.0148242
NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 0.0148152
LTAP1 lipid transport auxiliary protein 1 0.0147732
FRMD5 FERM domain containing 5 0.0146716
RAI1 retinoic acid induced 1 0.0146332
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0146239
SERINC3 serine incorporator 3 0.0145865
RPL31 ribosomal protein L31 0.0145785
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0145059
WDPCP WD repeat containing planar cell polarity effector 0.0144959
ABHD2 abhydrolase domain containing 2 0.0144863
CAPN1 calpain 1, (mu/I) large subunit 0.0144743
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0144114
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0143645
DIS3L DIS3 like exosome 3'-5' exoribonuclease 0.0143644
H1-10 H1.10 linker histone 0.0143511
AAK1 AP2 associated kinase 1 0.0141445
RPL19 ribosomal protein L19 0.0141258
IDI1 isopentenyl-diphosphate delta isomerase 1 0.0141095
LARS1 leucyl-tRNA synthetase 1 0.0140972
CORO1B coronin, actin binding protein, 1B 0.0140726
CDC42 cell division cycle 42 0.0140653
ELOB elongin B 0.0140641
OSBPL9 oxysterol binding protein-like 9 0.0140599
FMNL2 formin-like 2 0.0140393
CMTM6 CKLF-like MARVEL transmembrane domain containing 6 0.0140206
KHSRP KH-type splicing regulatory protein 0.0140101
TRNP1 TMF1-regulated nuclear protein 1 0.0139764
ITM2B integral membrane protein 2B 0.0139728
MRRF mitochondrial ribosome recycling factor 0.0139489
USP9X ubiquitin specific peptidase 9, X-linked 0.0139346
BLVRB biliverdin reductase B 0.0138724
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 0.0138602
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0138476
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0137651
RAB3B RAB3B, member RAS oncogene family 0.0137414
RUVBL1 RuvB-like AAA ATPase 1 0.0136996
PKP4 plakophilin 4 0.0136503
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 0.0136111
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 0.0136055
DMXL2 Dmx-like 2 0.0135871
MSMO1 methylsterol monooxygenase 1 0.0135549
ENSA endosulfine alpha 0.0135373
ATG9A autophagy related 9A 0.0135026
CEP192 centrosomal protein 192kDa 0.0134839
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 0.0134518
RPL34 ribosomal protein L34 0.0134021
PAXBP1 PAX3 and PAX7 binding protein 1 0.0133682
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.0133524
TTC3 tetratricopeptide repeat domain 3 0.0133088
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 0.0132624
PHF12 PHD finger protein 12 0.0132541
KAT6B K(lysine) acetyltransferase 6B 0.0132475
TMSB10 thymosin beta 10 0.0132285
SCARB1 scavenger receptor class B, member 1 0.0132034
YBX3 Y box binding protein 3 0.0131897
TMEM230 transmembrane protein 230 0.0131859
RPL11 ribosomal protein L11 0.0131816
RPS21 ribosomal protein S21 0.0131376
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0131283
MGST1 microsomal glutathione S-transferase 1 0.0131091
MEF2D myocyte enhancer factor 2D 0.0130885
MYO1B myosin IB 0.0130208
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0129778
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0129229
CCDC112 coiled-coil domain containing 112 0.0128989
CSNK1D casein kinase 1, delta 0.0128103
CRTAP cartilage associated protein 0.0128004
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 0.0127882
CLCN5 chloride channel, voltage-sensitive 5 0.0127804
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 0.0127261
IARS1 isoleucyl-tRNA synthetase 1 0.012723
PIGT phosphatidylinositol glycan anchor biosynthesis, class T 0.0127099
BFAR bifunctional apoptosis regulator 0.0126933
FBXO22 F-box protein 22 0.0126559
HKDC1 hexokinase domain containing 1 0.0126364
SH2D4A SH2 domain containing 4A 0.012622
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) 0.0126138
ADD1 adducin 1 (alpha) 0.0126103
VAT1 vesicle amine transport 1 0.0125996
RABGAP1 RAB GTPase activating protein 1 0.0125925
ADIPOR2 adiponectin receptor 2 0.01256
AVL9 AVL9 homolog (S. cerevisiase) 0.0125538
CYRIB CYFIP related Rac1 interactor B 0.0125424
WDFY1 WD repeat and FYVE domain containing 1 0.0125335
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) 0.012524
NPC1 Niemann-Pick disease, type C1 0.0125059
CENPF centromere protein F, 350/400kDa 0.0124633
VPS35L VPS35 endosomal protein sorting factor like 0.0124585
CFDP1 craniofacial development protein 1 0.0124131
EYA4 EYA transcriptional coactivator and phosphatase 4 0.0123832
ATG10 autophagy related 10 0.0123711
GPATCH2 G patch domain containing 2 0.012346
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0123295
CHD6 chromodomain helicase DNA binding protein 6 0.0123247
GPAA1 glycosylphosphatidylinositol anchor attachment 1 0.0123036
TARS1 threonyl-tRNA synthetase 1 0.0122839
TBC1D16 TBC1 domain family, member 16 0.012281
HLA-E major histocompatibility complex, class I, E 0.0122584
ERICH1 glutamate-rich 1 0.0122528
ERCC6L2 excision repair cross-complementation group 6-like 2 0.0122479
PHB2 prohibitin 2 0.0122379
TPM3 tropomyosin 3 0.0122257
NAMPT nicotinamide phosphoribosyltransferase 0.0122242
RHEB Ras homolog enriched in brain 0.012207
LDLRAD4 low density lipoprotein receptor class A domain containing 4 0.0122013
TTC19 tetratricopeptide repeat domain 19 0.0121547
SOX12 SRY (sex determining region Y)-box 12 0.0121405
RPS23 ribosomal protein S23 0.0121375
MAN2A1 mannosidase, alpha, class 2A, member 1 0.0121172
ELOVL5 ELOVL fatty acid elongase 5 0.0120875
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0120546
ZFHX3 zinc finger homeobox 3 0.0120227
RAB7A RAB7A, member RAS oncogene family 0.0120101
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 0.0119901
WDR13 WD repeat domain 13 0.0119885
SND1 staphylococcal nuclease and tudor domain containing 1 0.0119822
PTPRA protein tyrosine phosphatase, receptor type, A 0.0119598
SC5D sterol-C5-desaturase 0.0119392
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) 0.0119225
XYLB xylulokinase homolog (H. influenzae) 0.0119203
UBC ubiquitin C 0.0119165
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9 0.0119087
MEGF9 multiple EGF-like-domains 9 0.0118759
FAM177A1 family with sequence similarity 177, member A1 0.0118553
RPSA ribosomal protein SA 0.0118056
MVP major vault protein 0.011804
DOCK7 dedicator of cytokinesis 7 0.0117907
GFOD1 glucose-fructose oxidoreductase domain containing 1 0.0117767
TRIML2 tripartite motif family-like 2 0.0117414
ENOSF1 enolase superfamily member 1 0.0117338
BTN3A3 butyrophilin, subfamily 3, member A3 0.0117294
HEXB hexosaminidase B (beta polypeptide) 0.0117056
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0116927
MTMR14 myotubularin related protein 14 0.0116836
NBEA neurobeachin 0.0116787
IRS2 insulin receptor substrate 2 0.0116714
FCHSD2 FCH and double SH3 domains 2 0.0115707
MORF4L2 mortality factor 4 like 2 0.0115597
STAT5B signal transducer and activator of transcription 5B 0.0115505
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) 0.0115415
CPPED1 calcineurin-like phosphoesterase domain containing 1 0.0115403
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 0.0115353
YARS1 tyrosyl-tRNA synthetase 1 0.0115273
BSG basigin (Ok blood group) 0.0115218
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0115048
G6PC3 glucose 6 phosphatase, catalytic, 3 0.0114663
KLHL36 kelch-like family member 36 0.0114639
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0114553
COPG2 coatomer protein complex, subunit gamma 2 0.0114458
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0114405
STIM1 stromal interaction molecule 1 0.0114397
GEN1 GEN1 Holliday junction 5' flap endonuclease 0.0114055
FXYD5 FXYD domain containing ion transport regulator 5 0.0113973
CMTM8 CKLF-like MARVEL transmembrane domain containing 8 0.0113806
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.0113535
KIAA1958 KIAA1958 0.0113527
RBM33 RNA binding motif protein 33 0.0113524
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 0.0113417
IRF3 interferon regulatory factor 3 0.0113353
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1 0.0113336
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0113324
RAB26 RAB26, member RAS oncogene family 0.0113277
DCTN1 dynactin 1 0.0113274
KIF20B kinesin family member 20B 0.0113268
RPLP2 ribosomal protein, large, P2 0.0113098
SIGMAR1 sigma non-opioid intracellular receptor 1 0.0113074
CEP89 centrosomal protein 89kDa 0.0112973
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.0112899
NOP14 NOP14 nucleolar protein 0.0112648
RAD21 RAD21 homolog (S. pombe) 0.0112324
SYTL2 synaptotagmin-like 2 0.0112288
TUBGCP2 tubulin, gamma complex associated protein 2 0.0111808
TM7SF2 transmembrane 7 superfamily member 2 0.0111612
RAB33B RAB33B, member RAS oncogene family 0.0111455
RPL8 ribosomal protein L8 0.0111433
SHB Src homology 2 domain containing adaptor protein B 0.011116
KIF3A kinesin family member 3A 0.0110924
ECH1 enoyl CoA hydratase 1, peroxisomal 0.0110779
CCDC6 coiled-coil domain containing 6 0.011061
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0110463
SET SET nuclear proto-oncogene 0.0110422
PTPRG protein tyrosine phosphatase, receptor type, G 0.0110356
EIF3K eukaryotic translation initiation factor 3, subunit K 0.0110296
LRRC23 leucine rich repeat containing 23 0.0110024
TACC1 transforming, acidic coiled-coil containing protein 1 0.0109772
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 0.0109735
SEPTIN11 septin 11 0.0109544
MISO1 mitochondrial inner membrane subdomain organizer 1 0.0109096
UBE2Z ubiquitin-conjugating enzyme E2Z 0.0109066
RNF115 ring finger protein 115 0.0108552
NAP1L4 nucleosome assembly protein 1-like 4 0.010818
NR2F2 nuclear receptor subfamily 2, group F, member 2 0.0108082
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa 0.0108007
ABHD12 abhydrolase domain containing 12 0.0107605
MSH2 mutS homolog 2 0.0107507
SLC35F6 solute carrier family 35, member F6 0.01075
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0107458
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 0.0107371
ABHD17B abhydrolase domain containing 17B 0.0107371
ERP29 endoplasmic reticulum protein 29 0.0107262
AKAP10 A kinase (PRKA) anchor protein 10 0.0107228
RSL24D1 ribosomal L24 domain containing 1 0.010714
ACYP2 acylphosphatase 2, muscle type 0.0106961
ZNF586 zinc finger protein 586 0.0106716
SOGA1 suppressor of glucose, autophagy associated 1 0.0106647
RCN1 reticulocalbin 1, EF-hand calcium binding domain 0.0106468
AFG3L2 AFG3-like AAA ATPase 2 0.0106454
CYB5R3 cytochrome b5 reductase 3 0.0106343
SNX2 sorting nexin 2 0.0106079
FANCC Fanconi anemia, complementation group C 0.0106061
CHD1 chromodomain helicase DNA binding protein 1 0.0105881
GALK2 galactokinase 2 0.0105797
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 0.010578
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0105759
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 0.0105559
SERGEF secretion regulating guanine nucleotide exchange factor 0.0105433
CTSA cathepsin A 0.0105412
TMED3 transmembrane emp24 protein transport domain containing 3 0.0105367
HMGXB3 HMG box domain containing 3 0.0105111
WDR7 WD repeat domain 7 0.0104737
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0104654
PARD3B par-3 family cell polarity regulator beta 0.0104503
FBXW8 F-box and WD repeat domain containing 8 0.0104444
KRIT1 KRIT1, ankyrin repeat containing 0.0104334
TXNDC9 thioredoxin domain containing 9 0.0104039
DYNLL1 dynein, light chain, LC8-type 1 0.010368
PGAP6 post-GPI attachment to proteins 6 0.0103625
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0103327
MBD4 methyl-CpG binding domain protein 4 0.010312
DIAPH2 diaphanous-related formin 2 0.0103056
COL27A1 collagen, type XXVII, alpha 1 0.0102963
DNM3 dynamin 3 0.0102899
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 0.0102787
KRCC1 lysine-rich coiled-coil 1 0.0102768
TNPO3 transportin 3 0.0102701
CEP55 centrosomal protein 55kDa 0.0102568
TMEM18 transmembrane protein 18 0.0102494
RAB29 RAB29, member RAS oncogene family 0.0102421
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0102182
SCAF11 SR-related CTD-associated factor 11 0.0102111
COG8 component of oligomeric golgi complex 8 0.0102022
CHD3 chromodomain helicase DNA binding protein 3 0.0101559
TULP4 tubby like protein 4 0.0101388
ELP6 elongator acetyltransferase complex subunit 6 0.0101249
SORT1 sortilin 1 0.0101211
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0101125
OSTM1 osteopetrosis associated transmembrane protein 1 0.0101095
SHTN1 shootin 1 0.0100914
GALNS galactosamine (N-acetyl)-6-sulfatase 0.0100881
MNT MAX network transcriptional repressor 0.0100552
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast) 0.010049
PNMA2 paraneoplastic Ma antigen 2 0.0100486
PIEZO1 piezo-type mechanosensitive ion channel component 1 0.0100447
ORAI2 ORAI calcium release-activated calcium modulator 2 0.0100167
FKBP3 FK506 binding protein 3, 25kDa 0.0100074
QARS1 glutaminyl-tRNA synthetase 1 0.00998431
RB1CC1 RB1-inducible coiled-coil 1 0.00998141
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 0.00996806
ARRB1 arrestin, beta 1 0.00996315
HDAC2 histone deacetylase 2 0.00995479
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) 0.00995159
RPL37A ribosomal protein L37a 0.00994525
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.00993716
TOP2B topoisomerase (DNA) II beta 180kDa 0.00992102
AP3S2 adaptor-related protein complex 3, sigma 2 subunit 0.00989895
MUC13 mucin 13, cell surface associated 0.00989826
MCM6 minichromosome maintenance complex component 6 0.00988012
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.00987385
ADCY5 adenylate cyclase 5 0.00986612
ITGAV integrin, alpha V 0.0098605
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.00985307
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.00985134
SERP1 stress-associated endoplasmic reticulum protein 1 0.00983646

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.17712
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.132233
MYO1E myosin IE -0.108323
CUX1 cut-like homeobox 1 -0.0913634
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0852682
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0811197
EHBP1 EH domain binding protein 1 -0.0772796
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0693424
MCU mitochondrial calcium uniporter -0.0669665
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0668171
NCOA3 nuclear receptor coactivator 3 -0.0640519
PRKCA protein kinase C, alpha -0.0584451
PDE10A phosphodiesterase 10A -0.0578511
WWOX WW domain containing oxidoreductase -0.0547452
KYNU kynureninase -0.0530017
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.0529098
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0527935
CMIP c-Maf inducing protein -0.0521694
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.051931
DENND5B DENN/MADD domain containing 5B -0.0519125
NF1 neurofibromin 1 -0.0513661
IGF1R insulin-like growth factor 1 receptor -0.049295
CNTNAP3B contactin associated protein-like 3B -0.0479128
NRG1 neuregulin 1 -0.0463509
MTUS1 microtubule associated tumor suppressor 1 -0.0452788
JMJD1C jumonji domain containing 1C -0.0449089
ARHGAP26 Rho GTPase activating protein 26 -0.0439563
PCDH9 protocadherin 9 -0.0437906
MACF1 microtubule-actin crosslinking factor 1 -0.0434206
NPAS2 neuronal PAS domain protein 2 -0.0433002
GPC6 glypican 6 -0.0431619
USP34 ubiquitin specific peptidase 34 -0.0427192
PDE8A phosphodiesterase 8A -0.0423185
UGDH UDP-glucose 6-dehydrogenase -0.0420193
FN1 fibronectin 1 -0.0419988
TTC28 tetratricopeptide repeat domain 28 -0.0417962
EFNA5 ephrin-A5 -0.0411081
SLC39A11 solute carrier family 39, member 11 -0.0410833
BCAS3 breast carcinoma amplified sequence 3 -0.0400526
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0398041
NFIA nuclear factor I/A -0.0392371
DOCK5 dedicator of cytokinesis 5 -0.0386394
GLG1 golgi glycoprotein 1 -0.0381639
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0379637
CNTN1 contactin 1 -0.0378402
PTGR1 prostaglandin reductase 1 -0.0362029
SSH2 slingshot protein phosphatase 2 -0.0356371
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0347472
WAC WW domain containing adaptor with coiled-coil -0.0340766
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0339985
RNF145 ring finger protein 145 -0.0333843
PTPRM protein tyrosine phosphatase, receptor type, M -0.0328798
CEMIP2 cell migration inducing hyaluronidase 2 -0.0321063
PON2 paraoxonase 2 -0.0320497
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0319837
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0319331
PBX1 pre-B-cell leukemia homeobox 1 -0.0316958
FILIP1 filamin A interacting protein 1 -0.0313569
PPARG peroxisome proliferator-activated receptor gamma -0.0312044
MYO10 myosin X -0.0310486
SIK3 SIK family kinase 3 -0.0308092
DAPK1 death-associated protein kinase 1 -0.0303741
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0301072
ACTN4 actinin, alpha 4 -0.0298713
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 -0.0298234
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0296421
TCF12 transcription factor 12 -0.0295879
GRAMD1A GRAM domain containing 1A -0.0292406
XPO1 exportin 1 -0.0290558
WWC1 WW and C2 domain containing 1 -0.0289589
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0289126
BIRC6 baculoviral IAP repeat containing 6 -0.0287432
PDE7B phosphodiesterase 7B -0.0286432
PTK2 protein tyrosine kinase 2 -0.0285798
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0285205
CLASP2 cytoplasmic linker associated protein 2 -0.0281471
AKAP13 A kinase (PRKA) anchor protein 13 -0.0281172
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0279212
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0279049
EXOC6B exocyst complex component 6B -0.0278429
NOL10 nucleolar protein 10 -0.0276775
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0275376
TNPO1 transportin 1 -0.0275193
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit -0.0272053
FOXP1 forkhead box P1 -0.027096
EVA1C eva-1 homolog C (C. elegans) -0.0268982
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0268194
TNRC6B trinucleotide repeat containing 6B -0.0266338
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0265339
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0263246
NSD2 nuclear receptor binding SET domain protein 2 -0.026285
GRAMD1B GRAM domain containing 1B -0.0261321
CSNK2A2 casein kinase 2, alpha prime polypeptide -0.0259519
TBC1D5 TBC1 domain family, member 5 -0.0259221
THSD4 thrombospondin, type I, domain containing 4 -0.0259007
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -0.0258467
TAOK3 TAO kinase 3 -0.0257747
PROC protein C (inactivator of coagulation factors Va and VIIIa) -0.0257447
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 -0.0256555
CD151 CD151 molecule (Raph blood group) -0.0256481
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa -0.0252547
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.025121
FRMD3 FERM domain containing 3 -0.0249976
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0247818
VMP1 vacuole membrane protein 1 -0.0246096
RDX radixin -0.0245007
RNF213 ring finger protein 213 -0.0243721
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0242485
TPR translocated promoter region, nuclear basket protein -0.0241274
VEZT vezatin, adherens junctions transmembrane protein -0.0241004
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0239468
SMYD3 SET and MYND domain containing 3 -0.0237839
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0237316
THOC2 THO complex 2 -0.0233894
OPHN1 oligophrenin 1 -0.0232178
ANXA4 annexin A4 -0.0230987
PLEKHA6 pleckstrin homology domain containing, family A member 6 -0.022938
SCAF8 SR-related CTD-associated factor 8 -0.0229256
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0228937
FNDC3B fibronectin type III domain containing 3B -0.0228824
ZMYND8 zinc finger, MYND-type containing 8 -0.022817
CLIP2 CAP-GLY domain containing linker protein 2 -0.0227554
SMOX spermine oxidase -0.0227443
TACC2 transforming, acidic coiled-coil containing protein 2 -0.0227166
CDC27 cell division cycle 27 -0.0227047
FAM107B family with sequence similarity 107, member B -0.0226881
AGFG1 ArfGAP with FG repeats 1 -0.0225734
ARHGAP12 Rho GTPase activating protein 12 -0.0225094
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0224929
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 -0.0223393
RBPMS RNA binding protein with multiple splicing -0.0222184
R3HDM1 R3H domain containing 1 -0.0221707
METTL16 methyltransferase like 16 -0.0220859
UBE3C ubiquitin protein ligase E3C -0.0219547
KIFC3 kinesin family member C3 -0.0217244
COL5A2 collagen, type V, alpha 2 -0.0216128
MAP7 microtubule-associated protein 7 -0.0215459
SRSF4 serine/arginine-rich splicing factor 4 -0.02151
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 -0.0214265
PM20D1 peptidase M20 domain containing 1 -0.0213458
FAF2 Fas associated factor family member 2 -0.0213411
SLC38A2 solute carrier family 38, member 2 -0.0211995
THRB thyroid hormone receptor, beta -0.0211462
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0210205
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0209975
MRTFB myocardin related transcription factor B -0.0209526
GOLM2 golgi membrane protein 2 -0.0207783
SMAD3 SMAD family member 3 -0.0207605
TMEM164 transmembrane protein 164 -0.0207261
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -0.020623
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 -0.0205084
SP3 Sp3 transcription factor -0.0205006
BCL2L1 BCL2-like 1 -0.0204711
STRN3 striatin, calmodulin binding protein 3 -0.0203986
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 -0.0202847
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -0.0201521
HM13 histocompatibility (minor) 13 -0.0199003
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0198459
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.0198366
ADAM10 ADAM metallopeptidase domain 10 -0.0198225
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.019785
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0197825
AGO2 argonaute RISC catalytic component 2 -0.0197505
GPATCH8 G patch domain containing 8 -0.0197442
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0197154
ARID4B AT rich interactive domain 4B (RBP1-like) -0.019663
GMDS GDP-mannose 4,6-dehydratase -0.0196437
NEBL nebulette -0.019569
KDM6A lysine (K)-specific demethylase 6A -0.0195051
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0194693
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0194611
ZNF609 zinc finger protein 609 -0.0194339
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 -0.0194114
GSK3B glycogen synthase kinase 3 beta -0.0194081
INTS2 integrator complex subunit 2 -0.0194054
RTN3 reticulon 3 -0.0194018
GTF2IRD1 GTF2I repeat domain containing 1 -0.0193144
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0192929
SPIDR scaffolding protein involved in DNA repair -0.0192668
SAMD4B sterile alpha motif domain containing 4B -0.0192652
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0192495
ELL2 elongation factor, RNA polymerase II, 2 -0.0192113
GATAD2B GATA zinc finger domain containing 2B -0.0191727
PTCD3 pentatricopeptide repeat domain 3 -0.0191683
STK24 serine/threonine kinase 24 -0.0191348
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0190873
ATE1 arginyltransferase 1 -0.0190643
FOXN2 forkhead box N2 -0.0190429
PDE4B phosphodiesterase 4B, cAMP-specific -0.0188468
RFWD3 ring finger and WD repeat domain 3 -0.0186402
NUMB numb homolog (Drosophila) -0.0186328
DUSP16 dual specificity phosphatase 16 -0.0186279
KDM2A lysine (K)-specific demethylase 2A -0.0185831
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0184073
S100A10 S100 calcium binding protein A10 -0.0183915
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0183753
ZSWIM5 zinc finger, SWIM-type containing 5 -0.0183263
NCOR2 nuclear receptor corepressor 2 -0.0183074
SRPK1 SRSF protein kinase 1 -0.0183026
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0182995
TFCP2 transcription factor CP2 -0.0182541
SYMPK symplekin -0.0182312
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0181934
LIN9 lin-9 DREAM MuvB core complex component -0.0180654
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 -0.0179945
TENT2 terminal nucleotidyltransferase 2 -0.0179199
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 -0.0178606
NCEH1 neutral cholesterol ester hydrolase 1 -0.017849
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0177572
SDCCAG8 serologically defined colon cancer antigen 8 -0.0177347
ZNRF3 zinc and ring finger 3 -0.0176955
CD44 CD44 molecule (Indian blood group) -0.0176838
TUFM Tu translation elongation factor, mitochondrial -0.0176198
ACBD6 acyl-CoA binding domain containing 6 -0.0176032
APP amyloid beta (A4) precursor protein -0.0175674
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0175542
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.0175531
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0175504
DSCAM Down syndrome cell adhesion molecule -0.0175313
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0174461
PCNX2 pecanex 2 -0.017427
RBM39 RNA binding motif protein 39 -0.017422
DENND4A DENN/MADD domain containing 4A -0.0174189
RNF111 ring finger protein 111 -0.0174068
TCERG1 transcription elongation regulator 1 -0.0172743
IGSF11 immunoglobulin superfamily, member 11 -0.0171754
FAM13B family with sequence similarity 13, member B -0.0171443
YAP1 Yes-associated protein 1 -0.0170444
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) -0.0170101
CST3 cystatin C -0.016989
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0169866
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) -0.0169058
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0168372
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.0167419
SPNS1 spinster homolog 1 (Drosophila) -0.0166984
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0166753
QKI QKI, KH domain containing, RNA binding -0.01662
RANBP17 RAN binding protein 17 -0.0166063
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0165807
BICC1 BicC family RNA binding protein 1 -0.0165787
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0165712
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) -0.0165639
EHD2 EH-domain containing 2 -0.0165459
SETDB1 SET domain, bifurcated 1 -0.0164982
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 -0.0164479
KIAA1671 KIAA1671 -0.0164332
PHF21A PHD finger protein 21A -0.0164178
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -0.0163435
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0162238
ITGB4 integrin, beta 4 -0.016199
STXBP4 syntaxin binding protein 4 -0.0161649
ADD3 adducin 3 (gamma) -0.0161572
CDK13 cyclin-dependent kinase 13 -0.0159889
ADGRL2 adhesion G protein-coupled receptor L2 -0.0159856
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0159722
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0159669
SCARA5 scavenger receptor class A, member 5 -0.0159487
SENP6 SUMO1/sentrin specific peptidase 6 -0.0159215
SCFD1 sec1 family domain containing 1 -0.0158002
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0157299
RPN1 ribophorin I -0.0157065
MPRIP myosin phosphatase Rho interacting protein -0.015656
PACS1 phosphofurin acidic cluster sorting protein 1 -0.015634
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0156245
CREBBP CREB binding protein -0.0156137
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0155908
ADPGK ADP-dependent glucokinase -0.0155125
WDFY2 WD repeat and FYVE domain containing 2 -0.0154912
SOS1 son of sevenless homolog 1 (Drosophila) -0.0154696
NCOA1 nuclear receptor coactivator 1 -0.0154264
STK39 serine threonine kinase 39 -0.0154054
WSB1 WD repeat and SOCS box containing 1 -0.0153869
NECTIN2 nectin cell adhesion molecule 2 -0.0153383
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 -0.0153281
MORF4L1 mortality factor 4 like 1 -0.0152623
TUBD1 tubulin, delta 1 -0.0152063
CCNI cyclin I -0.0151649
UBE2O ubiquitin-conjugating enzyme E2O -0.0151097
FAM13A family with sequence similarity 13, member A -0.0150811
USP53 ubiquitin specific peptidase 53 -0.0150247
MAML3 mastermind-like 3 (Drosophila) -0.0149776
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) -0.0149478
MYOF myoferlin -0.014947
NOTCH3 notch 3 -0.014926
MAP4 microtubule-associated protein 4 -0.0149046
PTPRF protein tyrosine phosphatase, receptor type, F -0.0148533
NUDC nudC nuclear distribution protein -0.0148461
TM4SF4 transmembrane 4 L six family member 4 -0.0148376
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 -0.0148339
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0148123
PCLO piccolo presynaptic cytomatrix protein -0.0148084
ENAH enabled homolog (Drosophila) -0.0147398
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -0.0147359
SYNGAP1 synaptic Ras GTPase activating protein 1 -0.0147249
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0146897
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0146814
NSD1 nuclear receptor binding SET domain protein 1 -0.0145694
MALT1 MALT1 paracaspase -0.0145145
RASAL2 RAS protein activator like 2 -0.014489
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0144705
EPAS1 endothelial PAS domain protein 1 -0.0144664
ARL15 ADP-ribosylation factor-like 15 -0.0144638
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0144151
AXL AXL receptor tyrosine kinase -0.0144138
TP63 tumor protein p63 -0.0143701
CTBP2 C-terminal binding protein 2 -0.0143364
HDLBP high density lipoprotein binding protein -0.0143184
SRC SRC proto-oncogene, non-receptor tyrosine kinase -0.0142935
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0142843
LRP11 low density lipoprotein receptor-related protein 11 -0.0142834
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0142661
PLPP1 phospholipid phosphatase 1 -0.0142525
CDK17 cyclin-dependent kinase 17 -0.0142494
RCOR1 REST corepressor 1 -0.014213
BMPR1B bone morphogenetic protein receptor, type IB -0.0141707
CDKL5 cyclin-dependent kinase-like 5 -0.014139
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 -0.014066
PRKCE protein kinase C, epsilon -0.014059
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta -0.0140464
MSN moesin -0.013968
WAPL WAPL cohesin release factor -0.013965
MAPK9 mitogen-activated protein kinase 9 -0.013965
TNRC18 trinucleotide repeat containing 18 -0.0139625
ZBTB20 zinc finger and BTB domain containing 20 -0.0139269
USP15 ubiquitin specific peptidase 15 -0.0138977
DGKD diacylglycerol kinase, delta 130kDa -0.0138907
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) -0.0138598
PPP4R3A protein phosphatase 4 regulatory subunit 3A -0.0138571
MBNL2 muscleblind-like splicing regulator 2 -0.01384
GDI2 GDP dissociation inhibitor 2 -0.0138214
AGR2 anterior gradient 2 -0.0138087
CASTOR2 cytosolic arginine sensor for mTORC1 subunit 2 -0.0138072
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0138027
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0138023
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 -0.0137397
HNF1A HNF1 homeobox A -0.0137364
MSI2 musashi RNA-binding protein 2 -0.013712
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0137021
SMIM44 small integral membrane protein 44 -0.0136711
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.013639
FAM193A family with sequence similarity 193, member A -0.0136368
BMP6 bone morphogenetic protein 6 -0.0136349
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0136199
AATF apoptosis antagonizing transcription factor -0.0136136
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0136074
TRAF3 TNF receptor-associated factor 3 -0.0135998
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0135967
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0135911
BASP1 brain abundant, membrane attached signal protein 1 -0.0135448
ADGRG6 adhesion G protein-coupled receptor G6 -0.0135296
DGUOK deoxyguanosine kinase -0.0135111
CADM1 cell adhesion molecule 1 -0.0135111
DTNB dystrobrevin, beta -0.0134931
ATL2 atlastin GTPase 2 -0.013489
PROCR protein C receptor, endothelial -0.0134755
CCDC88A coiled-coil domain containing 88A -0.0134703
PDE7A phosphodiesterase 7A -0.0134478
APTX aprataxin -0.013425
UBAP2 ubiquitin associated protein 2 -0.0134155
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0134153
NAV3 neuron navigator 3 -0.0134131
RGS3 regulator of G-protein signaling 3 -0.0133962
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa -0.0133676
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0133464
RHOBTB1 Rho-related BTB domain containing 1 -0.0133338
TMEM245 transmembrane protein 245 -0.0133212
MED13L mediator complex subunit 13-like -0.0133073
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A -0.0132745
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) -0.0132653
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0132396
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0132062
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0132023
CXORF38 chromosome X open reading frame 38 -0.0131981
ZFC3H1 zinc finger, C3H1-type containing -0.0131796
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 -0.0131731
HDAC8 histone deacetylase 8 -0.0131621
ATP11B ATPase, class VI, type 11B -0.013157
ZBTB4 zinc finger and BTB domain containing 4 -0.0131222
PRKCSH protein kinase C substrate 80K-H -0.0130999
DPYSL2 dihydropyrimidinase-like 2 -0.0130998
SH3KBP1 SH3-domain kinase binding protein 1 -0.0130773
KLHL22 kelch-like family member 22 -0.0130632
NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 -0.0130631
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -0.0130524
FCGBP Fc fragment of IgG binding protein -0.0130501
KIDINS220 kinase D-interacting substrate, 220kDa -0.0130435
MRTFA myocardin related transcription factor A -0.01299
TNS3 tensin 3 -0.0129864
RRAS2 related RAS viral (r-ras) oncogene homolog 2 -0.0129582
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase -0.0129387
WDR44 WD repeat domain 44 -0.0129209
ANXA2 annexin A2 -0.0129179
HNRNPL heterogeneous nuclear ribonucleoprotein L -0.0129111
SCFD2 sec1 family domain containing 2 -0.0128935
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0128911
ZMAT4 zinc finger, matrin-type 4 -0.012872
TRAM2 translocation associated membrane protein 2 -0.0128554
NUMA1 nuclear mitotic apparatus protein 1 -0.0128511
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0128453
SH3RF2 SH3 domain containing ring finger 2 -0.0128409
TGFB2 transforming growth factor, beta 2 -0.0128362
UBXN2A UBX domain protein 2A -0.0128337
TOP3A topoisomerase (DNA) III alpha -0.0128271
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0128097
ZCCHC10 zinc finger, CCHC domain containing 10 -0.0128025
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme -0.0127552
SERBP1 SERPINE1 mRNA binding protein 1 -0.012754
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 -0.0127435
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 -0.0127128
HOMER2 homer scaffolding protein 2 -0.0127011
MYO18A myosin XVIIIA -0.0126954
MIDEAS mitotic deacetylase associated SANT domain protein -0.0126358
MIS18BP1 MIS18 binding protein 1 -0.0126024
LY6E lymphocyte antigen 6 complex, locus E -0.0125907
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa -0.0125809
SIDT1 SID1 transmembrane family, member 1 -0.0125785
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0125569
WWP1 WW domain containing E3 ubiquitin protein ligase 1 -0.0125442
STOX2 storkhead box 2 -0.0125272
SLC35F3 solute carrier family 35, member F3 -0.0125251
SF1 splicing factor 1 -0.0125044
MAGT1 magnesium transporter 1 -0.0124962
PRPF8 pre-mRNA processing factor 8 -0.0124818
SYNRG synergin, gamma -0.0124758
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) -0.0124653
RPS13 ribosomal protein S13 -0.0124439
ADGRA3 adhesion G protein-coupled receptor A3 -0.0124318
CDC73 cell division cycle 73 -0.0124126
OGT O-linked N-acetylglucosamine (GlcNAc) transferase -0.0123722
PCNT pericentrin -0.0123645
ARMC9 armadillo repeat containing 9 -0.0123603
RARB retinoic acid receptor, beta -0.0123595
SRRM1 serine/arginine repetitive matrix 1 -0.0123499
NBEAL1 neurobeachin-like 1 -0.0123415
TANGO6 transport and golgi organization 6 homolog (Drosophila) -0.0123365
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 -0.0123324
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 -0.0123222
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -0.0122795
LYPLA1 lysophospholipase I -0.0122745
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0122491
MSH3 mutS homolog 3 -0.0122408
CAAP1 caspase activity and apoptosis inhibitor 1 -0.0122289
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0122276
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) -0.0121997
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -0.0121845
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0121576
AUP1 ancient ubiquitous protein 1 -0.0121464
TMCC1 transmembrane and coiled-coil domain family 1 -0.0121456
SPACA6 sperm acrosome associated 6 -0.0121454
DHDDS dehydrodolichyl diphosphate synthase -0.0121289
PCNX1 pecanex 1 -0.0121267
TUBA1C tubulin, alpha 1c -0.0121163
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -0.012113
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0120833
DDB1 damage-specific DNA binding protein 1, 127kDa -0.0120666
PHC3 polyhomeotic homolog 3 (Drosophila) -0.0120584
FGG fibrinogen gamma chain -0.0120486
TTC17 tetratricopeptide repeat domain 17 -0.0120341
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 -0.0120333
SPATA17 spermatogenesis associated 17 -0.0120227
FAF1 Fas (TNFRSF6) associated factor 1 -0.0120168
FANCI Fanconi anemia, complementation group I -0.0119926
HNRNPR heterogeneous nuclear ribonucleoprotein R -0.0119787
USP36 ubiquitin specific peptidase 36 -0.01195
TUT4 terminal uridylyl transferase 4 -0.0119423
SNX4 sorting nexin 4 -0.0119297
RNF138 ring finger protein 138, E3 ubiquitin protein ligase -0.0118822
XXYLT1 xyloside xylosyltransferase 1 -0.01184
KCNT2 potassium channel, sodium activated subfamily T, member 2 -0.0118331
EXT1 exostosin glycosyltransferase 1 -0.0118316
MPHOSPH9 M-phase phosphoprotein 9 -0.0118282
NEMF nuclear export mediator factor -0.0117965
TBX18 T-box 18 -0.0117875
ARF4 ADP-ribosylation factor 4 -0.0117845
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0117793
TSEN2 TSEN2 tRNA splicing endonuclease subunit -0.0117788
CNKSR3 CNKSR family member 3 -0.0117753
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.011731
HOOK3 hook microtubule-tethering protein 3 -0.0116722
FAM168A family with sequence similarity 168, member A -0.011648
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0116433
FOSL1 FOS-like antigen 1 -0.0116396
KIF16B kinesin family member 16B -0.0116367
SBNO1 strawberry notch homolog 1 (Drosophila) -0.0116349
WIPF2 WAS/WASL interacting protein family, member 2 -0.0116249
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.0115918
METTL15 methyltransferase like 15 -0.0115818
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.0115757
PRICKLE2 prickle homolog 2 (Drosophila) -0.0115748
PTPRK protein tyrosine phosphatase, receptor type, K -0.0115734
CEP112 centrosomal protein 112kDa -0.0115722
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.011572
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0115619
TCOF1 Treacher Collins-Franceschetti syndrome 1 -0.0115458
ZFAND6 zinc finger, AN1-type domain 6 -0.0115164
TPM4 tropomyosin 4 -0.0114998
EPC1 enhancer of polycomb homolog 1 (Drosophila) -0.0114977
TATDN1 TatD DNase domain containing 1 -0.0114942
SETD2 SET domain containing 2 -0.0114889
RTTN rotatin -0.0114879