A549_NVP-BSK805 2HCl_10nM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description NVP-BSK805 2HCl 10nM perturbation in A549 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the A549_NVP-BSK805 2HCl_10nM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
KRT8 keratin 8, type II 0.144501
FTL ferritin, light polypeptide 0.111753
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.10822
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0938834
KRT81 keratin 81, type II 0.0784918
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0752854
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0740707
RPLP1 ribosomal protein, large, P1 0.072062
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0707604
AKR1C3 aldo-keto reductase family 1, member C3 0.0696382
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0663947
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0655225
PKM pyruvate kinase, muscle 0.0654965
ACTN4 actinin, alpha 4 0.0647179
RAB10 RAB10, member RAS oncogene family 0.0618978
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.0608621
PLEC plectin 0.060824
CLU clusterin 0.0598119
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.05484
MAP1B microtubule-associated protein 1B 0.0539672
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0538883
FLNA filamin A, alpha 0.0538574
TPI1 triosephosphate isomerase 1 0.0519497
AKR1C2 aldo-keto reductase family 1, member C2 0.0517695
MPG N-methylpurine-DNA glycosylase 0.0512794
TPM3 tropomyosin 3 0.0510648
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0508977
GLIS3 GLIS family zinc finger 3 0.0505802
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0501362
MUSK muscle, skeletal, receptor tyrosine kinase 0.0495672
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0478874
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0471661
FLNB filamin B, beta 0.0463063
RBM47 RNA binding motif protein 47 0.0460697
S100A10 S100 calcium binding protein A10 0.0458145
CENPF centromere protein F, 350/400kDa 0.045082
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0449234
MAP4 microtubule-associated protein 4 0.0441316
PRRC2C proline-rich coiled-coil 2C 0.0438045
TLN1 talin 1 0.0431475
RPS11 ribosomal protein S11 0.042858
KRT18 keratin 18, type I 0.0424281
DOCK10 dedicator of cytokinesis 10 0.0411218
FTH1 ferritin, heavy polypeptide 1 0.0408277
CENPP centromere protein P 0.0399075
IPO9 importin 9 0.0397261
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0396632
TPM4 tropomyosin 4 0.0393746
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0393661
KPNB1 karyopherin (importin) beta 1 0.0390519
RPS2 ribosomal protein S2 0.0388731
MBNL1 muscleblind-like splicing regulator 1 0.0383424
PRDX1 peroxiredoxin 1 0.0377839
GPX2 glutathione peroxidase 2 0.0375466
TUBB tubulin, beta class I 0.0375013
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0368283
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.0366478
MEGF9 multiple EGF-like-domains 9 0.0365645
MYO19 myosin XIX 0.0364336
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0353196
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0351552
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.0350912
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 0.0348989
THADA thyroid adenoma associated 0.0346389
RPL23 ribosomal protein L23 0.0345826
TNS3 tensin 3 0.0345434
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0344312
DST dystonin 0.0342674
SLC38A1 solute carrier family 38, member 1 0.0338893
PFN1 profilin 1 0.0338351
NCAPD2 non-SMC condensin I complex, subunit D2 0.0336981
EFTUD2 elongation factor Tu GTP binding domain containing 2 0.0332046
HSPH1 heat shock 105kDa/110kDa protein 1 0.033085
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0329907
TM4SF1 transmembrane 4 L six family member 1 0.0327748
DSTN destrin (actin depolymerizing factor) 0.0325729
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0320827
NRCAM neuronal cell adhesion molecule 0.0318943
AGO3 argonaute RISC catalytic component 3 0.0318039
PCYOX1 prenylcysteine oxidase 1 0.0313603
UBL4A ubiquitin-like 4A 0.0313381
NRP1 neuropilin 1 0.0312575
POTEF POTE ankyrin domain family, member F 0.0309488
TBC1D5 TBC1 domain family, member 5 0.0308962
MAP7 microtubule-associated protein 7 0.0307549
SMC4 structural maintenance of chromosomes 4 0.0307287
BRD3 bromodomain containing 3 0.0304171
CMIP c-Maf inducing protein 0.0303993
EYA4 EYA transcriptional coactivator and phosphatase 4 0.0301211
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0298549
EZR ezrin 0.0298096
TCP1 t-complex 1 0.0296125
GPHN gephyrin 0.0296083
CCND3 cyclin D3 0.0296021
RPL19 ribosomal protein L19 0.0294893
CD151 CD151 molecule (Raph blood group) 0.0293367
NOP56 NOP56 ribonucleoprotein 0.0291871
OSBPL10 oxysterol binding protein-like 10 0.0287497
SFT2D2 SFT2 domain containing 2 0.0283513
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.0278775
CADM1 cell adhesion molecule 1 0.0277871
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.027682
TPR translocated promoter region, nuclear basket protein 0.0275042
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 0.0274129
IPO7 importin 7 0.0273843
JAK1 Janus kinase 1 0.0273786
LARP1 La ribonucleoprotein domain family, member 1 0.0272247
PELP1 proline, glutamate and leucine rich protein 1 0.0269845
ZC3H13 zinc finger CCCH-type containing 13 0.026814
CEP350 centrosomal protein 350kDa 0.0268082
DCTN4 dynactin 4 (p62) 0.0265244
ANKRD28 ankyrin repeat domain 28 0.0264296
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0261879
RPS14 ribosomal protein S14 0.0260395
BIRC6 baculoviral IAP repeat containing 6 0.0258306
CD44 CD44 molecule (Indian blood group) 0.0258046
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 0.0254103
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0253937
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.0253928
YBX1 Y box binding protein 1 0.025154
SKP1 S-phase kinase-associated protein 1 0.0251421
TCERG1 transcription elongation regulator 1 0.0250945
RPS3 ribosomal protein S3 0.0249763
SYNGR2 synaptogyrin 2 0.0247386
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0247098
MGST1 microsomal glutathione S-transferase 1 0.0244646
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.0244164
UBE2H ubiquitin-conjugating enzyme E2H 0.024265
PLD5 phospholipase D family, member 5 0.0242062
MRTFB myocardin related transcription factor B 0.0241737
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0240987
METTL15 methyltransferase like 15 0.0240617
PLS1 plastin 1 0.0239682
AREG amphiregulin 0.023939
XPC xeroderma pigmentosum, complementation group C 0.0238488
SPC25 SPC25, NDC80 kinetochore complex component 0.0237857
S100A6 S100 calcium binding protein A6 0.0237787
RAD51B RAD51 paralog B 0.0237087
ABLIM1 actin binding LIM protein 1 0.0235867
RPSA ribosomal protein SA 0.0235584
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) 0.023367
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0233629
CA12 carbonic anhydrase XII 0.023155
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0231337
PBX1 pre-B-cell leukemia homeobox 1 0.0230885
APLP2 amyloid beta (A4) precursor-like protein 2 0.0230865
UBE2G2 ubiquitin-conjugating enzyme E2G 2 0.0230041
SEPTIN7 septin 7 0.0229539
ATP13A3 ATPase type 13A3 0.0229516
MCM4 minichromosome maintenance complex component 4 0.0227795
CCT3 chaperonin containing TCP1, subunit 3 (gamma) 0.0227779
SETD3 SET domain containing 3 0.0227521
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.0226216
RPL37A ribosomal protein L37a 0.0226073
RPH3AL rabphilin 3A-like (without C2 domains) 0.0225972
APMAP adipocyte plasma membrane associated protein 0.0225913
MRPL13 mitochondrial ribosomal protein L13 0.0223869
PLCH1 phospholipase C, eta 1 0.0223528
PCM1 pericentriolar material 1 0.0223448
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0223252
TPD52 tumor protein D52 0.0222865
KIF20B kinesin family member 20B 0.0222131
MTPN myotrophin 0.0221961
KIF14 kinesin family member 14 0.0221918
HDGF hepatoma-derived growth factor 0.0221639
TUT7 terminal uridylyl transferase 7 0.0221638
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 0.0221382
UBP1 upstream binding protein 1 (LBP-1a) 0.0219363
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.0219073
CKAP4 cytoskeleton-associated protein 4 0.0218855
REPS1 RALBP1 associated Eps domain containing 1 0.021883
DLG1 discs, large homolog 1 (Drosophila) 0.021869
TXNRD1 thioredoxin reductase 1 0.0218357
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 0.0217816
SCARB2 scavenger receptor class B, member 2 0.0217229
ACTG1 actin gamma 1 0.0216838
ZBTB20 zinc finger and BTB domain containing 20 0.0216742
KIF2A kinesin heavy chain member 2A 0.0216434
PHGDH phosphoglycerate dehydrogenase 0.0216242
CTSB cathepsin B 0.0215604
BPTF bromodomain PHD finger transcription factor 0.0214573
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) 0.0214508
RBL1 retinoblastoma-like 1 0.0213815
HELLS helicase, lymphoid-specific 0.0213773
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 0.0213144
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor 0.0213111
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.0212803
EXOC4 exocyst complex component 4 0.0212117
ILF2 interleukin enhancer binding factor 2 0.0210901
CDCA2 cell division cycle associated 2 0.021064
SPIDR scaffolding protein involved in DNA repair 0.0210522
GSTCD glutathione S-transferase, C-terminal domain containing 0.0210231
ACACA acetyl-CoA carboxylase alpha 0.0209252
PRKX protein kinase, X-linked 0.020915
DIAPH1 diaphanous-related formin 1 0.0209058
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0209045
CGGBP1 CGG triplet repeat binding protein 1 0.0207159
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.020696
ECT2 epithelial cell transforming 2 0.0206478
RTN4 reticulon 4 0.0206476
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0206168
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0206081
LRP6 low density lipoprotein receptor-related protein 6 0.0205616
BRI3BP BRI3 binding protein 0.0204845
DCAF1 DDB1 and CUL4 associated factor 1 0.0204521
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0203383
ZNF618 zinc finger protein 618 0.0203268
PIGO phosphatidylinositol glycan anchor biosynthesis, class O 0.0203029
SERBP1 SERPINE1 mRNA binding protein 1 0.0202304
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.0202069
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0201872
ZNF281 zinc finger protein 281 0.0201184
SETX senataxin 0.0200844
MBD4 methyl-CpG binding domain protein 4 0.020073
AP1M2 adaptor-related protein complex 1, mu 2 subunit 0.0198765
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.019875
AKR1C1 aldo-keto reductase family 1, member C1 0.0198596
NIPBL Nipped-B homolog (Drosophila) 0.0198323
YIPF4 Yip1 domain family, member 4 0.0197903
TGFBR3 transforming growth factor, beta receptor III 0.0197669
BASP1 brain abundant, membrane attached signal protein 1 0.0196893
WDR62 WD repeat domain 62 0.0196774
ADAM10 ADAM metallopeptidase domain 10 0.0195914
GTF2I general transcription factor IIi 0.0195141
RPS9 ribosomal protein S9 0.0195034
NCBP1 nuclear cap binding protein subunit 1, 80kDa 0.0194878
STIP1 stress-induced phosphoprotein 1 0.0194635
EIF4A3 eukaryotic translation initiation factor 4A3 0.0194273
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 0.0194273
ATL2 atlastin GTPase 2 0.0194245
CBX5 chromobox homolog 5 0.0193966
CKAP5 cytoskeleton associated protein 5 0.0193767
WDR45 WD repeat domain 45 0.0193203
CHD4 chromodomain helicase DNA binding protein 4 0.0192686
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 0.0192005
RPS7 ribosomal protein S7 0.0191481
ENO1 enolase 1, (alpha) 0.0191334
PRKCE protein kinase C, epsilon 0.0190964
RBBP8 retinoblastoma binding protein 8 0.0190717
HMGA1 high mobility group AT-hook 1 0.0189917
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 0.0189297
CCDC68 coiled-coil domain containing 68 0.0188359
CELF1 CUGBP, Elav-like family member 1 0.0188312
KIAA0232 KIAA0232 0.0187688
FGFR1 fibroblast growth factor receptor 1 0.0187635
XPO1 exportin 1 0.0187496
POLDIP3 polymerase (DNA-directed), delta interacting protein 3 0.018697
MEF2D myocyte enhancer factor 2D 0.0186565
SRP72 signal recognition particle 72kDa 0.0186132
BLZF1 basic leucine zipper nuclear factor 1 0.0185861
EEF1B2 eukaryotic translation elongation factor 1 beta 2 0.0185851
PHF14 PHD finger protein 14 0.0184579
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 0.0184321
AHNAK2 AHNAK nucleoprotein 2 0.0183821
ERH enhancer of rudimentary homolog (Drosophila) 0.0183392
EIF1AX eukaryotic translation initiation factor 1A, X-linked 0.0183062
PPP1R9A protein phosphatase 1, regulatory subunit 9A 0.0182921
TM7SF3 transmembrane 7 superfamily member 3 0.0182453
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0181908
STX1A syntaxin 1A (brain) 0.0181796
ADAM9 ADAM metallopeptidase domain 9 0.0181723
WDR83OS WD repeat domain 83 opposite strand 0.0181691
XYLB xylulokinase homolog (H. influenzae) 0.0180783
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) 0.0180733
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 0.0180501
PLXNA2 plexin A2 0.0180483
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) 0.0180017
GSE1 Gse1 coiled-coil protein 0.0179909
RPL37 ribosomal protein L37 0.0179907
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 0.0179781
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0179284
TRERF1 transcriptional regulating factor 1 0.0178987
TFPI2 tissue factor pathway inhibitor 2 0.017891
SOCS5 suppressor of cytokine signaling 5 0.0178864
CCDC138 coiled-coil domain containing 138 0.0178776
LIMD1 LIM domains containing 1 0.0178719
EPB41L4A erythrocyte membrane protein band 4.1 like 4A 0.017869
ECPAS Ecm29 proteasome adaptor and scaffold 0.0178306
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0178212
NOL10 nucleolar protein 10 0.0177648
PTPN21 protein tyrosine phosphatase, non-receptor type 21 0.0176649
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 0.0176545
PCNX1 pecanex 1 0.0176462
GDI2 GDP dissociation inhibitor 2 0.0176193
DCTN2 dynactin 2 (p50) 0.0176108
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0175827
ACER3 alkaline ceramidase 3 0.0175818
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 0.0175812
NXN nucleoredoxin 0.0174601
PEAK1 pseudopodium-enriched atypical kinase 1 0.0174556
ADD1 adducin 1 (alpha) 0.0174349
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.0173803
QARS1 glutaminyl-tRNA synthetase 1 0.0173324
ANO6 anoctamin 6 0.0173048
DTD1 D-tyrosyl-tRNA deacylase 1 0.0172842
NUP210 nucleoporin 210kDa 0.0172401
PBRM1 polybromo 1 0.0171623
HJURP Holliday junction recognition protein 0.0170782
FUCA2 fucosidase, alpha-L- 2, plasma 0.0170211
ANKLE2 ankyrin repeat and LEM domain containing 2 0.0169941
BCL9L B-cell CLL/lymphoma 9-like 0.016992
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.0169628
PALB2 partner and localizer of BRCA2 0.016953
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 0.0169207
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2 0.0169134
HIBADH 3-hydroxyisobutyrate dehydrogenase 0.0168877
MYO5A myosin VA (heavy chain 12, myoxin) 0.0168706
CANX calnexin 0.0168435
NEIL3 nei endonuclease VIII-like 3 (E. coli) 0.0168369
FLOT2 flotillin 2 0.0167546
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 0.0167454
YLPM1 YLP motif containing 1 0.0167405
ENOX2 ecto-NOX disulfide-thiol exchanger 2 0.0167362
AATF apoptosis antagonizing transcription factor 0.016736
STRBP spermatid perinuclear RNA binding protein 0.0166397
SNAP29 synaptosomal-associated protein, 29kDa 0.0166194
MEIS2 Meis homeobox 2 0.016614
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) 0.0166014
FANCL Fanconi anemia, complementation group L 0.016505
SRGN serglycin 0.0164522
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.0163959
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0163947
MYO1B myosin IB 0.0163833
DTNB dystrobrevin, beta 0.0163361
CCDC18 coiled-coil domain containing 18 0.0163258
CHLSN cholesin 0.0162303
NCLN nicalin 0.0162254
RCL1 RNA terminal phosphate cyclase-like 1 0.0162254
PLEKHA6 pleckstrin homology domain containing, family A member 6 0.0161237
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.01612
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0160919
ITFG1 integrin alpha FG-GAP repeat containing 1 0.0160836
TTC17 tetratricopeptide repeat domain 17 0.0160748
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0160692
PARP1 poly (ADP-ribose) polymerase 1 0.0160625
VCP valosin containing protein 0.016062
SSRP1 structure specific recognition protein 1 0.0160396
CCDC137 coiled-coil domain containing 137 0.0160263
RAI1 retinoic acid induced 1 0.0160183
ACTN1 actinin, alpha 1 0.016008
CTSD cathepsin D 0.0159975
SOCS6 suppressor of cytokine signaling 6 0.0159892
DSPP dentin sialophosphoprotein 0.0159891
HMGA2 high mobility group AT-hook 2 0.0159737
CEP85 centrosomal protein 85kDa 0.0159351
IPO5 importin 5 0.0159013
SMC3 structural maintenance of chromosomes 3 0.0158431
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0158319
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 0.0157578
CADM2 cell adhesion molecule 2 0.0157292
HKDC1 hexokinase domain containing 1 0.0157099
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0156903
MED29 mediator complex subunit 29 0.0156824
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 0.0156682
CAV2 caveolin 2 0.0156589
PHKA1 phosphorylase kinase, alpha 1 (muscle) 0.0156542
TTC19 tetratricopeptide repeat domain 19 0.0156358
FADS2 fatty acid desaturase 2 0.0156339
RHBDL2 rhomboid, veinlet-like 2 (Drosophila) 0.015628
FBL fibrillarin 0.015609
LMNA lamin A/C 0.0155543
TMPRSS4 transmembrane protease, serine 4 0.015551
FRMD5 FERM domain containing 5 0.0155207
JADE1 jade family PHD finger 1 0.0155072
CDKL5 cyclin-dependent kinase-like 5 0.015493
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0154668
CENPE centromere protein E, 312kDa 0.0154536
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0154461
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.015427
MPZL1 myelin protein zero-like 1 0.0154073
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa 0.0153976
TFG TRK-fused gene 0.0153967
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0153952
MCM7 minichromosome maintenance complex component 7 0.0153817
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.0153586
IL6ST interleukin 6 signal transducer 0.0153542
PANK3 pantothenate kinase 3 0.0153527
INSL4 insulin-like 4 (placenta) 0.0153433
SLCO3A1 solute carrier organic anion transporter family, member 3A1 0.0153276
RTN4RL2 reticulon 4 receptor-like 2 0.0153252
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.015312
KDM5A lysine (K)-specific demethylase 5A 0.0153005
LAMP1 lysosomal-associated membrane protein 1 0.0152895
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) 0.0152889
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 0.0152879
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0152815
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0152727
E2F3 E2F transcription factor 3 0.0152461
CERS6 ceramide synthase 6 0.0151996
RAB34 RAB34, member RAS oncogene family 0.015186
C21ORF58 chromosome 21 open reading frame 58 0.0151841
METTL2A methyltransferase like 2A 0.0151765
SMC1A structural maintenance of chromosomes 1A 0.0151672
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.015155
CPT1A carnitine palmitoyltransferase 1A (liver) 0.0151324
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0151063
AFAP1 actin filament associated protein 1 0.0150625
EEF2 eukaryotic translation elongation factor 2 0.0150488
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.015021
DOCK1 dedicator of cytokinesis 1 0.0150175
SLC45A4 solute carrier family 45, member 4 0.015015
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4 0.0150066
UBN1 ubinuclein 1 0.0149868
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 0.0149455
MRE11 MRE11 homolog, double strand break repair nuclease 0.014931
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0149137
PPP4R3A protein phosphatase 4 regulatory subunit 3A 0.0149077
KANK2 KN motif and ankyrin repeat domains 2 0.014894
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0148576
CARS1 cysteinyl-tRNA synthetase 1 0.014841
GCFC2 GC-rich sequence DNA-binding factor 2 0.0148316
HSPG2 heparan sulfate proteoglycan 2 0.0148313
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0148305
MYDGF myeloid-derived growth factor 0.0148268
GCLM glutamate-cysteine ligase, modifier subunit 0.0148251
RPL5 ribosomal protein L5 0.0148127
EIPR1 EARP complex and GARP complex interacting protein 1 0.0147904
HSPA4 heat shock 70kDa protein 4 0.0147878
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 0.0147704
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.0147383
NIN ninein (GSK3B interacting protein) 0.0147378
CEP89 centrosomal protein 89kDa 0.014725
PCED1B PC-esterase domain containing 1B 0.0147036
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0147021
TRAM1 translocation associated membrane protein 1 0.0147004
RPL7 ribosomal protein L7 0.0146995
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 0.0146761
PDCD6IP programmed cell death 6 interacting protein 0.0146535
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) 0.0146465
TK1 thymidine kinase 1, soluble 0.0146427
ZSCAN5A zinc finger and SCAN domain containing 5A 0.014604
SKA2 spindle and kinetochore associated complex subunit 2 0.0145346
PTMA prothymosin, alpha 0.0145323
FKBP14 FK506 binding protein 14, 22 kDa 0.014524
MIX23 mitochondrial matrix import factor 23 0.0145208
CACUL1 CDK2-associated, cullin domain 1 0.0145149
EPAS1 endothelial PAS domain protein 1 0.0144993
ZNF37A zinc finger protein 37A 0.0144824
NOL8 nucleolar protein 8 0.0144634
RAB7A RAB7A, member RAS oncogene family 0.0144465
LDLR low density lipoprotein receptor 0.0144316
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0144205
CD2AP CD2-associated protein 0.0144106
SYNRG synergin, gamma 0.0143938
FXYD5 FXYD domain containing ion transport regulator 5 0.0143396
EPS8L2 EPS8-like 2 0.0143271
LONP2 lon peptidase 2, peroxisomal 0.0143254
MELTF melanotransferrin 0.0143135
DNPEP aspartyl aminopeptidase 0.0143125
PNISR PNN-interacting serine/arginine-rich protein 0.014308
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0142533
TAMM41 TAM41, mitochondrial translocator assembly and maintenance protein, homolog (S. cerevisiae) 0.0142419
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 0.0142351
NSRP1 nuclear speckle splicing regulatory protein 1 0.0142174
USP12 ubiquitin specific peptidase 12 0.014205
EMC10 ER membrane protein complex subunit 10 0.0141121
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.0141077
ZNF562 zinc finger protein 562 0.0140585
H3-3B H3.3 histone B 0.0140578
RPL39 ribosomal protein L39 0.0140323
USP49 ubiquitin specific peptidase 49 0.0140205
PDCD11 programmed cell death 11 0.0140149
OSBPL1A oxysterol binding protein-like 1A 0.0140132
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 0.0139991
GIPC1 GIPC PDZ domain containing family, member 1 0.0139818
CLTC clathrin, heavy chain (Hc) 0.0139698
RPN1 ribophorin I 0.0139627
KLF13 Kruppel-like factor 13 0.0139556
RPL32 ribosomal protein L32 0.0139387
NUDCD3 NudC domain containing 3 0.0139354
KRT7 keratin 7, type II 0.013935
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing 0.0139346
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 0.013932
MSRB3 methionine sulfoxide reductase B3 0.0139224
NIPSNAP1 nipsnap homolog 1 (C. elegans) 0.0139112
RHEB Ras homolog enriched in brain 0.0138928
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 0.0138807
ANKFY1 ankyrin repeat and FYVE domain containing 1 0.0138776
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.0138664
PDZD2 PDZ domain containing 2 0.0138613
PUM3 pumilio RNA binding family member 3 0.0138494
ANKRD12 ankyrin repeat domain 12 0.0138367
PIR pirin (iron-binding nuclear protein) 0.013832
SF3B4 splicing factor 3b, subunit 4, 49kDa 0.0138272
CBR4 carbonyl reductase 4 0.0138057
GTSE1 G-2 and S-phase expressed 1 0.0138032
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.0137826
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 0.0137815
PKP4 plakophilin 4 0.0137691
TMTC3 transmembrane and tetratricopeptide repeat containing 3 0.0137684
KIF21A kinesin family member 21A 0.013764
TESC tescalcin 0.0137621
AHCTF1 AT hook containing transcription factor 1 0.0137419
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 0.0137151
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.0137108
SLC35F3 solute carrier family 35, member F3 0.0136969
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 0.0136835
EBPL emopamil binding protein-like 0.0136691
ZFAND5 zinc finger, AN1-type domain 5 0.0136609
GPR135 G protein-coupled receptor 135 0.0136578

decreased expression

Symbol Name Standardized Value
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.127133
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.109317
FN1 fibronectin 1 -0.104183
EHBP1 EH domain binding protein 1 -0.0998492
KYNU kynureninase -0.0866255
PRKCA protein kinase C, alpha -0.0737041
WWOX WW domain containing oxidoreductase -0.0696542
CNTNAP3B contactin associated protein-like 3B -0.0654939
MYO1E myosin IE -0.0636602
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0580196
ITGB5 integrin, beta 5 -0.0579914
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.055147
PDE8A phosphodiesterase 8A -0.0509734
FOXP1 forkhead box P1 -0.0509713
PTPRM protein tyrosine phosphatase, receptor type, M -0.0495497
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0489562
SYT1 synaptotagmin I -0.0488665
ZNF609 zinc finger protein 609 -0.0485601
MED13L mediator complex subunit 13-like -0.0473598
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0465545
DENND5B DENN/MADD domain containing 5B -0.0449227
GPATCH8 G patch domain containing 8 -0.0448581
MRTFA myocardin related transcription factor A -0.0445405
FAM222B family with sequence similarity 222, member B -0.0432307
PTGR1 prostaglandin reductase 1 -0.0431493
NINL ninein-like -0.0430377
BMPR1B bone morphogenetic protein receptor, type IB -0.0430229
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0429996
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0428441
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0425906
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0418385
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0414179
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0411987
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0411689
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0410641
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0403687
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0403323
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0399843
CHD9 chromodomain helicase DNA binding protein 9 -0.0396524
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0392847
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0392833
TRIO trio Rho guanine nucleotide exchange factor -0.0389385
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0389211
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0388653
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0382242
IGF1R insulin-like growth factor 1 receptor -0.0381583
SMAD3 SMAD family member 3 -0.0374906
NCOA2 nuclear receptor coactivator 2 -0.0374544
LRMDA leucine rich melanocyte differentiation associated -0.0369034
APP amyloid beta (A4) precursor protein -0.0368351
BCAS3 breast carcinoma amplified sequence 3 -0.0361435
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 -0.0360747
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0353279
ATXN2 ataxin 2 -0.0352391
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.0352322
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0351318
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0350736
RAP1B RAP1B, member of RAS oncogene family -0.0349955
MSI2 musashi RNA-binding protein 2 -0.0346655
SOS1 son of sevenless homolog 1 (Drosophila) -0.0344019
THSD4 thrombospondin, type I, domain containing 4 -0.033896
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0337732
DOCK5 dedicator of cytokinesis 5 -0.0337501
PTPRK protein tyrosine phosphatase, receptor type, K -0.0334579
PDE10A phosphodiesterase 10A -0.0333239
FNBP4 formin binding protein 4 -0.0331327
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0331011
COL4A5 collagen, type IV, alpha 5 -0.0328981
HIPK3 homeodomain interacting protein kinase 3 -0.0328177
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0323794
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) -0.0322403
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0321849
TAOK3 TAO kinase 3 -0.0320864
STRN3 striatin, calmodulin binding protein 3 -0.032002
AKAP13 A kinase (PRKA) anchor protein 13 -0.0319348
SMAD2 SMAD family member 2 -0.031668
STK38 serine/threonine kinase 38 -0.0314743
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0311756
STAU2 staufen double-stranded RNA binding protein 2 -0.0309462
ACBD3 acyl-CoA binding domain containing 3 -0.0309282
PDE4B phosphodiesterase 4B, cAMP-specific -0.0308184
FILIP1 filamin A interacting protein 1 -0.0303314
AVL9 AVL9 homolog (S. cerevisiase) -0.0303111
MBOAT7 membrane bound O-acyltransferase domain containing 7 -0.0302098
MTUS1 microtubule associated tumor suppressor 1 -0.030139
ARHGAP26 Rho GTPase activating protein 26 -0.0301346
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 -0.029948
FAM107B family with sequence similarity 107, member B -0.0297045
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0295846
SVIL supervillin -0.0295389
MYOF myoferlin -0.0292494
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -0.029148
NFIA nuclear factor I/A -0.029016
ANKRD11 ankyrin repeat domain 11 -0.0289671
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0288069
UBASH3B ubiquitin associated and SH3 domain containing B -0.0286939
WWC1 WW and C2 domain containing 1 -0.028615
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0285867
SLC38A2 solute carrier family 38, member 2 -0.0285589
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0285243
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0285133
RASAL2 RAS protein activator like 2 -0.0284936
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0284352
LITAF lipopolysaccharide-induced TNF factor -0.0281578
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.028101
ZSWIM5 zinc finger, SWIM-type containing 5 -0.028051
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -0.0280406
UTRN utrophin -0.0278243
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -0.0276267
NECTIN2 nectin cell adhesion molecule 2 -0.0271013
NT5C2 5'-nucleotidase, cytosolic II -0.0270737
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0270462
FBXL20 F-box and leucine-rich repeat protein 20 -0.0266673
AHI1 Abelson helper integration site 1 -0.0263561
TLK1 tousled-like kinase 1 -0.0263538
ACYP2 acylphosphatase 2, muscle type -0.0263145
LIMCH1 LIM and calponin homology domains 1 -0.0263121
MORF4L1 mortality factor 4 like 1 -0.0263053
NTN4 netrin 4 -0.0262585
RARS1 arginyl-tRNA synthetase 1 -0.0261283
SH3RF1 SH3 domain containing ring finger 1 -0.0260677
NCOA1 nuclear receptor coactivator 1 -0.0260512
PATJ PATJ crumbs cell polarity complex component -0.0258641
UBC ubiquitin C -0.0257277
HM13 histocompatibility (minor) 13 -0.0256854
MPRIP myosin phosphatase Rho interacting protein -0.02561
EML4 echinoderm microtubule associated protein like 4 -0.0255822
MEGF8 multiple EGF-like-domains 8 -0.0254804
RBM6 RNA binding motif protein 6 -0.025432
PSD3 pleckstrin and Sec7 domain containing 3 -0.0253765
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0251995
PUM2 pumilio RNA-binding family member 2 -0.0251929
USP9X ubiquitin specific peptidase 9, X-linked -0.0251701
MLXIP MLX interacting protein -0.025118
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 -0.0250926
BRD4 bromodomain containing 4 -0.0250277
BICRAL BICRA like chromatin remodeling complex associated protein -0.0250223
NR2C1 nuclear receptor subfamily 2, group C, member 1 -0.0249516
NCOR1 nuclear receptor corepressor 1 -0.0249411
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0248587
CLIP2 CAP-GLY domain containing linker protein 2 -0.0247861
PEX14 peroxisomal biogenesis factor 14 -0.0247427
MICU1 mitochondrial calcium uptake 1 -0.0245029
CPNE8 copine VIII -0.0244965
TACC2 transforming, acidic coiled-coil containing protein 2 -0.0244883
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0244232
MCPH1 microcephalin 1 -0.0243315
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0243162
DSCAM Down syndrome cell adhesion molecule -0.0242443
MYO9A myosin IXA -0.0240522
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 -0.0239761
PTK2 protein tyrosine kinase 2 -0.0239726
BICD1 bicaudal D homolog 1 (Drosophila) -0.0239066
VDAC2 voltage-dependent anion channel 2 -0.0238831
TMEM156 transmembrane protein 156 -0.0238115
SDCCAG8 serologically defined colon cancer antigen 8 -0.0237063
PPP6R2 protein phosphatase 6, regulatory subunit 2 -0.0236859
ARL15 ADP-ribosylation factor-like 15 -0.0236343
TBC1D14 TBC1 domain family, member 14 -0.0235331
ZNF704 zinc finger protein 704 -0.0235257
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit -0.0234795
GPC6 glypican 6 -0.0234296
SFXN5 sideroflexin 5 -0.0234268
ICE2 interactor of little elongation complex ELL subunit 2 -0.0232415
RNF145 ring finger protein 145 -0.0232019
CUEDC1 CUE domain containing 1 -0.0231233
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 -0.02312
FGG fibrinogen gamma chain -0.0229942
PARD3B par-3 family cell polarity regulator beta -0.0229855
ZNF644 zinc finger protein 644 -0.0228847
SINHCAF SIN3-HDAC complex associated factor -0.0227335
AVEN apoptosis, caspase activation inhibitor -0.0227079
SGMS1 sphingomyelin synthase 1 -0.022695
CPPED1 calcineurin-like phosphoesterase domain containing 1 -0.0226217
DCP1A decapping mRNA 1A -0.0225402
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog -0.0224684
PLAUR plasminogen activator, urokinase receptor -0.0224413
VWA8 von Willebrand factor A domain containing 8 -0.0223107
IP6K2 inositol hexakisphosphate kinase 2 -0.0223088
SEPTIN6 septin 6 -0.0222855
CMTM4 CKLF-like MARVEL transmembrane domain containing 4 -0.022182
RHOBTB1 Rho-related BTB domain containing 1 -0.0220663
SUMF1 sulfatase modifying factor 1 -0.0220506
PDS5A PDS5 cohesin associated factor A -0.0219647
RPL8 ribosomal protein L8 -0.0219643
RSPO3 R-spondin 3 -0.0219071
ZER1 zyg-11 related, cell cycle regulator -0.0218689
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 -0.0218464
STIM1 stromal interaction molecule 1 -0.0218297
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0217901
USP47 ubiquitin specific peptidase 47 -0.0217875
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase -0.0217236
SP3 Sp3 transcription factor -0.0215594
PDE4D phosphodiesterase 4D, cAMP-specific -0.0215498
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0214695
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0214637
ENAH enabled homolog (Drosophila) -0.0214619
LTBP1 latent transforming growth factor beta binding protein 1 -0.021438
SEC11A SEC11 homolog A (S. cerevisiae) -0.0214238
DPP8 dipeptidyl-peptidase 8 -0.0214076
PRKN parkin RBR E3 ubiquitin protein ligase -0.021368
RAP1GAP2 RAP1 GTPase activating protein 2 -0.0213571
CSNK2A2 casein kinase 2, alpha prime polypeptide -0.0213487
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0213147
LUC7L LUC7-like (S. cerevisiae) -0.0212435
ESYT2 extended synaptotagmin-like protein 2 -0.0212149
MTA3 metastasis associated 1 family, member 3 -0.0211678
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 -0.0211224
CTBP2 C-terminal binding protein 2 -0.0210317
HOMER2 homer scaffolding protein 2 -0.0209973
SNX27 sorting nexin family member 27 -0.020923
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0208984
DOCK9 dedicator of cytokinesis 9 -0.0208569
SRPK2 SRSF protein kinase 2 -0.0207905
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0207718
KDM2A lysine (K)-specific demethylase 2A -0.0207168
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0206917
SSR1 signal sequence receptor, alpha -0.0206801
TP63 tumor protein p63 -0.0206561
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 -0.020644
MYLK myosin light chain kinase -0.0206374
PHF21A PHD finger protein 21A -0.0206339
SMOC1 SPARC related modular calcium binding 1 -0.0206329
ETV4 ets variant 4 -0.020474
ZFYVE9 zinc finger, FYVE domain containing 9 -0.0204387
USP36 ubiquitin specific peptidase 36 -0.0203765
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 -0.0203437
GRAMD1A GRAM domain containing 1A -0.0203062
MAVS mitochondrial antiviral signaling protein -0.0202664
RPAP2 RNA polymerase II associated protein 2 -0.0202388
BMPR1A bone morphogenetic protein receptor, type IA -0.0202382
PPARA peroxisome proliferator-activated receptor alpha -0.0202325
SH3D19 SH3 domain containing 19 -0.0201161
GRAMD1B GRAM domain containing 1B -0.0201132
SLA2 Src-like-adaptor 2 -0.0201057
SMOX spermine oxidase -0.0200333
TXLNG taxilin gamma -0.0199364
ZNRF3 zinc and ring finger 3 -0.019908
DUSP16 dual specificity phosphatase 16 -0.0198035
RACK1 receptor for activated C kinase 1 -0.0197352
TMEM164 transmembrane protein 164 -0.0196782
MYO1D myosin ID -0.0196669
BTG1 B-cell translocation gene 1, anti-proliferative -0.0196077
GNG12 guanine nucleotide binding protein (G protein), gamma 12 -0.0195734
LARP4 La ribonucleoprotein domain family, member 4 -0.0195199
TBCA tubulin folding cofactor A -0.0195173
LPIN2 lipin 2 -0.0194779
GAB2 GRB2-associated binding protein 2 -0.0194772
DCAKD dephospho-CoA kinase domain containing -0.0194172
NR1D2 nuclear receptor subfamily 1, group D, member 2 -0.0194155
ZZZ3 zinc finger, ZZ-type containing 3 -0.0193831
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) -0.0192749
CLMN calmin (calponin-like, transmembrane) -0.0192405
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 -0.0192156
TPT1 tumor protein, translationally-controlled 1 -0.0191457
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 -0.0191088
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0190929
OLA1 Obg-like ATPase 1 -0.0190696
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0190626
QKI QKI, KH domain containing, RNA binding -0.0190256
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -0.0189504
FNDC3B fibronectin type III domain containing 3B -0.0188346
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0188047
FAM193A family with sequence similarity 193, member A -0.0187867
MAML3 mastermind-like 3 (Drosophila) -0.0187523
PDLIM5 PDZ and LIM domain 5 -0.0187509
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0187318
CDK19 cyclin-dependent kinase 19 -0.0186054
PHACTR4 phosphatase and actin regulator 4 -0.018598
CNTN1 contactin 1 -0.0185349
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 -0.0185014
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -0.0184715
NFX1 nuclear transcription factor, X-box binding 1 -0.0184677
FHL2 four and a half LIM domains 2 -0.0184632
LPAR1 lysophosphatidic acid receptor 1 -0.0183995
CCDC57 coiled-coil domain containing 57 -0.0183888
RPS24 ribosomal protein S24 -0.0183762
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0183457
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1 -0.0183197
FOXO1 forkhead box O1 -0.0182798
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0182409
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -0.0182266
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.0182176
SMG5 SMG5 nonsense mediated mRNA decay factor -0.0181428
NVL nuclear VCP-like -0.0181314
FBXW11 F-box and WD repeat domain containing 11 -0.0180797
OSGIN2 oxidative stress induced growth inhibitor family member 2 -0.0180526
COG7 component of oligomeric golgi complex 7 -0.0180454
IQCB1 IQ motif containing B1 -0.0180055
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0179995
CABLES1 Cdk5 and Abl enzyme substrate 1 -0.0179236
ITSN2 intersectin 2 -0.0178671
PCSK5 proprotein convertase subtilisin/kexin type 5 -0.0178567
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.017852
TMEM168 transmembrane protein 168 -0.0178183
MLPH melanophilin -0.0177945
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme -0.0176135
RFX2 regulatory factor X, 2 (influences HLA class II expression) -0.0175642
LRRC28 leucine rich repeat containing 28 -0.0175471
PALLD palladin, cytoskeletal associated protein -0.0175374
MKKS McKusick-Kaufman syndrome -0.0175282
PLPP1 phospholipid phosphatase 1 -0.0175164
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 -0.0175156
FBXO36 F-box protein 36 -0.0174851
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0174744
PTOV1 prostate tumor overexpressed 1 -0.0174525
UBE2E1 ubiquitin-conjugating enzyme E2E 1 -0.0174473
CNPY2 canopy FGF signaling regulator 2 -0.0174031
FHIT fragile histidine triad -0.0173916
MBTD1 mbt domain containing 1 -0.0173724
KMT2A lysine (K)-specific methyltransferase 2A -0.0173271
STRN striatin, calmodulin binding protein -0.0173236
ZMAT4 zinc finger, matrin-type 4 -0.0173196
SMYD3 SET and MYND domain containing 3 -0.0173111
SCAPER S-phase cyclin A-associated protein in the ER -0.0173099
RAB11FIP3 RAB11 family interacting protein 3 (class II) -0.0173073
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) -0.0172755
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 -0.0172632
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) -0.0172485
WDFY1 WD repeat and FYVE domain containing 1 -0.0172422
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0172387
ABI2 abl-interactor 2 -0.0172336
UBE3C ubiquitin protein ligase E3C -0.0172278
MYO18A myosin XVIIIA -0.0171754
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0171729
PCDHB16 protocadherin beta 16 -0.017158
POFUT3 protein O-fucosyltransferase 3 -0.0171573
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) -0.0171054
ALPK1 alpha-kinase 1 -0.0170958
L2HGDH L-2-hydroxyglutarate dehydrogenase -0.0170731
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 -0.0170599
CXADR coxsackie virus and adenovirus receptor -0.017044
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.0170413
CCDC91 coiled-coil domain containing 91 -0.0170408
DSG2 desmoglein 2 -0.0170164
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) -0.017006
PKN1 protein kinase N1 -0.0169981
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.016974
RCOR1 REST corepressor 1 -0.0169682
HIP1 huntingtin interacting protein 1 -0.016933
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0169317
PCDH9 protocadherin 9 -0.0169108
KIF3B kinesin family member 3B -0.0168983
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.016878
LGSN lengsin, lens protein with glutamine synthetase domain -0.0168326
ZNF33A zinc finger protein 33A -0.0168104
MAP2K4 mitogen-activated protein kinase kinase 4 -0.0168098
SCAF8 SR-related CTD-associated factor 8 -0.0168065
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0168045
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains -0.0168001
TUBD1 tubulin, delta 1 -0.0167691
MACROD2 MACRO domain containing 2 -0.0167415
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -0.0167305
GSR glutathione reductase -0.0167179
CREB1 cAMP responsive element binding protein 1 -0.0166957
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0166882
ADIPOR2 adiponectin receptor 2 -0.0166798
EWSR1 EWS RNA-binding protein 1 -0.0166353
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) -0.016632
NEK7 NIMA-related kinase 7 -0.0166235
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0165594
UHMK1 U2AF homology motif (UHM) kinase 1 -0.0165529
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0165393
DENND6A DENN/MADD domain containing 6A -0.0165234
GLS2 glutaminase 2 (liver, mitochondrial) -0.0164831
SCN8A sodium channel, voltage gated, type VIII alpha subunit -0.0164538
FMNL2 formin-like 2 -0.0164527
KIAA0319 KIAA0319 -0.0164471
LSM12 LSM12 homolog (S. cerevisiae) -0.0164271
TNPO1 transportin 1 -0.0164116
UBE2J2 ubiquitin-conjugating enzyme E2, J2 -0.016376
RAB2A RAB2A, member RAS oncogene family -0.0163704
NBEA neurobeachin -0.0163498
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0163056
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha -0.016293
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) -0.016288
DENND1B DENN/MADD domain containing 1B -0.0162854
EFNA5 ephrin-A5 -0.0162843
SCRN1 secernin 1 -0.0162424
RPLP0 ribosomal protein, large, P0 -0.0162355
TMCC1 transmembrane and coiled-coil domain family 1 -0.0162113
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -0.0161666
WDSUB1 WD repeat, sterile alpha motif and U-box domain containing 1 -0.016166
AGFG1 ArfGAP with FG repeats 1 -0.0161358
KMT5B lysine methyltransferase 5B -0.0160591
CYRIB CYFIP related Rac1 interactor B -0.0160302
MRPS21 mitochondrial ribosomal protein S21 -0.0160248
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 -0.0160081
KATNIP katanin interacting protein -0.0160048
STK40 serine/threonine kinase 40 -0.0159931
RNF121 ring finger protein 121 -0.0159521
ZNF592 zinc finger protein 592 -0.0159263
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 -0.015922
ZDHHC17 zinc finger, DHHC-type containing 17 -0.0159207
GOLM2 golgi membrane protein 2 -0.0159157
FLVCR1 feline leukemia virus subgroup C cellular receptor 1 -0.0159062
SUMO1 small ubiquitin-like modifier 1 -0.0159044
IL17RA interleukin 17 receptor A -0.0158887
EPS15 epidermal growth factor receptor pathway substrate 15 -0.0158697
NONO non-POU domain containing, octamer-binding -0.0158579
SNX29 sorting nexin 29 -0.0158147
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0158123
RHOA ras homolog family member A -0.015805
GNB5 guanine nucleotide binding protein (G protein), beta 5 -0.0157782
PRPF3 pre-mRNA processing factor 3 -0.0157531
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0157477
DDB2 damage-specific DNA binding protein 2, 48kDa -0.0157314
MIDEAS mitotic deacetylase associated SANT domain protein -0.0157145
CEP85L centrosomal protein 85kDa-like -0.0156719
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -0.0156633
ATXN7 ataxin 7 -0.01562
COG5 component of oligomeric golgi complex 5 -0.0156135
TTC39B tetratricopeptide repeat domain 39B -0.0155948
LARP4B La ribonucleoprotein domain family, member 4B -0.0155679
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0155388
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 -0.0154836
TMEM165 transmembrane protein 165 -0.0154782
HEATR5B HEAT repeat containing 5B -0.0154335
MRNIP MRN complex interacting protein -0.015419
CD63 CD63 molecule -0.0154173
TMEM41B transmembrane protein 41B -0.0154025
ABHD12 abhydrolase domain containing 12 -0.0153781
DRC8 dynein regulatory complex subunit 8 -0.0153781
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 -0.0153365
ZNF207 zinc finger protein 207 -0.0153358
TENT2 terminal nucleotidyltransferase 2 -0.0152235
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 -0.0151963
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0151917
NRSN2 neurensin 2 -0.0151838
CTPS2 CTP synthase 2 -0.0151752
TTC7A tetratricopeptide repeat domain 7A -0.0151529
CAMK2G calcium/calmodulin-dependent protein kinase II gamma -0.0151245
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0151182
CRLF3 cytokine receptor-like factor 3 -0.0150937
FERMT1 fermitin family member 1 -0.0150908
WDPCP WD repeat containing planar cell polarity effector -0.0150434
LGALS8 lectin, galactoside-binding, soluble, 8 -0.0150397
NUAK1 NUAK family, SNF1-like kinase, 1 -0.0149801
RNF43 ring finger protein 43 -0.0149722
NAPEPLD N-acyl phosphatidylethanolamine phospholipase D -0.0149553
KIF16B kinesin family member 16B -0.0149447
GOSR1 golgi SNAP receptor complex member 1 -0.0149299
CACNG8 calcium channel, voltage-dependent, gamma subunit 8 -0.0149213
HNF1A HNF1 homeobox A -0.0149188
VEZT vezatin, adherens junctions transmembrane protein -0.0149069
NSD2 nuclear receptor binding SET domain protein 2 -0.0149025
TANK TRAF family member-associated NFKB activator -0.0149005
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0148953
VPS35L VPS35 endosomal protein sorting factor like -0.0148407
FKBP15 FK506 binding protein 15, 133kDa -0.0147591
SNAP25 synaptosomal-associated protein, 25kDa -0.0147587
TRA2A transformer 2 alpha homolog (Drosophila) -0.0147561
TXNDC11 thioredoxin domain containing 11 -0.0147519
SYT17 synaptotagmin XVII -0.0147513
ATOSA atos homolog A -0.0147408
UBAP2 ubiquitin associated protein 2 -0.0147336
SMG6 SMG6 nonsense mediated mRNA decay factor -0.0147103
TSC22D1 TSC22 domain family, member 1 -0.014689
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha -0.0146798
MSRA methionine sulfoxide reductase A -0.0146738
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0146668
MECP2 methyl CpG binding protein 2 -0.014662
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0146518
GPATCH2 G patch domain containing 2 -0.0146395
LCORL ligand dependent nuclear receptor corepressor-like -0.0146326
PARD3 par-3 family cell polarity regulator -0.0146308
CREM cAMP responsive element modulator -0.0146209
SLC35B4 solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4 -0.0145915
CLASRP CLK4-associating serine/arginine rich protein -0.0145719
RAB22A RAB22A, member RAS oncogene family -0.0145593
HDGFL3 HDGF like 3 -0.0145213
BCAS4 breast carcinoma amplified sequence 4 -0.0144627
TSC2 tuberous sclerosis 2 -0.0144576
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) -0.0144554
WAC WW domain containing adaptor with coiled-coil -0.0144325
SHTN1 shootin 1 -0.0144277
CD46 CD46 molecule, complement regulatory protein -0.0143791
NSUN6 NOP2/Sun domain family, member 6 -0.0143742
METTL16 methyltransferase like 16 -0.014368
NEMF nuclear export mediator factor -0.0143468
EIF4B eukaryotic translation initiation factor 4B -0.0143293
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0143076
SSH2 slingshot protein phosphatase 2 -0.0142999
CDK5RAP1 CDK5 regulatory subunit associated protein 1 -0.0142977
ARHGAP12 Rho GTPase activating protein 12 -0.0142808
TULP4 tubby like protein 4 -0.0142291
PRKD1 protein kinase D1 -0.0142044
DENND5A DENN/MADD domain containing 5A -0.0141771
BAZ1B bromodomain adjacent to zinc finger domain, 1B -0.0141602
FOCAD focadhesin -0.0141573
ADGRE5 adhesion G protein-coupled receptor E5 -0.0141526
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 -0.0141429
BCLAF1 BCL2-associated transcription factor 1 -0.014139
MOSMO modulator of smoothened -0.0141317
GDNF glial cell derived neurotrophic factor -0.0141209
DMWD dystrophia myotonica, WD repeat containing -0.0140601
CDC27 cell division cycle 27 -0.0140585
PNN pinin, desmosome associated protein -0.0140454
KMT2C lysine (K)-specific methyltransferase 2C -0.0140421
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0140375