A549_Obatoclax Mesylate_1µM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description Obatoclax Mesylate 1µM perturbation in A549 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the A549_Obatoclax Mesylate_1µM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.223621
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.175778
TXNRD1 thioredoxin reductase 1 0.0855586
FTL ferritin, light polypeptide 0.0819056
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0800562
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.072957
KRT18 keratin 18, type I 0.0721945
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0689741
NPAS2 neuronal PAS domain protein 2 0.0665236
ALCAM activated leukocyte cell adhesion molecule 0.0653553
GLIS3 GLIS family zinc finger 3 0.0634365
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0626642
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0626018
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0618875
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0617034
NCOA3 nuclear receptor coactivator 3 0.0584919
NRCAM neuronal cell adhesion molecule 0.0569
RORA RAR-related orphan receptor A 0.0554748
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.054232
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0528701
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0522151
ARHGAP11B Rho GTPase activating protein 11B 0.0513397
GCLC glutamate-cysteine ligase, catalytic subunit 0.0510357
CENPF centromere protein F, 350/400kDa 0.0499488
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0497075
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0493133
AKR1C2 aldo-keto reductase family 1, member C2 0.048091
DSTN destrin (actin depolymerizing factor) 0.0478264
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0470831
ACTG1 actin gamma 1 0.0463462
BICC1 BicC family RNA binding protein 1 0.045797
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0453815
RPL15 ribosomal protein L15 0.0450781
KDM2A lysine (K)-specific demethylase 2A 0.0442953
FTH1 ferritin, heavy polypeptide 1 0.0438405
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0404741
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0402518
AOPEP aminopeptidase O (putative) 0.03913
BSG basigin (Ok blood group) 0.0391211
ZMYND8 zinc finger, MYND-type containing 8 0.0383371
STK32B serine/threonine kinase 32B 0.0381859
MAP1B microtubule-associated protein 1B 0.0381479
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0380842
WDPCP WD repeat containing planar cell polarity effector 0.0374671
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 0.0373626
FN1 fibronectin 1 0.0373612
SMAD3 SMAD family member 3 0.0371628
GCLM glutamate-cysteine ligase, modifier subunit 0.0368086
RPLP1 ribosomal protein, large, P1 0.0363815
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0363163
RAB10 RAB10, member RAS oncogene family 0.0360777
DIAPH2 diaphanous-related formin 2 0.0360134
THOC2 THO complex 2 0.0356937
ATAD5 ATPase family, AAA domain containing 5 0.0355528
WDHD1 WD repeat and HMG-box DNA binding protein 1 0.0349732
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0340451
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0338889
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.0335261
DOCK1 dedicator of cytokinesis 1 0.0333582
TUBB tubulin, beta class I 0.0330533
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0330518
UBASH3B ubiquitin associated and SH3 domain containing B 0.0329938
MPG N-methylpurine-DNA glycosylase 0.0328754
TTC28 tetratricopeptide repeat domain 28 0.032704
PRKCA protein kinase C, alpha 0.0320967
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0319362
SH3D19 SH3 domain containing 19 0.0316912
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.0312978
S100A10 S100 calcium binding protein A10 0.0311051
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0309647
CMIP c-Maf inducing protein 0.0308567
CENPP centromere protein P 0.0308494
TMCC1 transmembrane and coiled-coil domain family 1 0.0307785
MKI67 marker of proliferation Ki-67 0.030689
UBTF upstream binding transcription factor, RNA polymerase I 0.0305047
MAP4 microtubule-associated protein 4 0.0301552
MORC4 MORC family CW-type zinc finger 4 0.029511
CUEDC1 CUE domain containing 1 0.0293372
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0291365
TMPO thymopoietin 0.0291172
TGOLN2 trans-golgi network protein 2 0.0286782
PTEN phosphatase and tensin homolog 0.0285376
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 0.0277609
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.027651
GLG1 golgi glycoprotein 1 0.027611
RPL8 ribosomal protein L8 0.0274722
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.027412
MYH9 myosin, heavy chain 9, non-muscle 0.0273813
TXN2 thioredoxin 2 0.0272221
NRP1 neuropilin 1 0.0267143
PFKP phosphofructokinase, platelet 0.026589
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0263046
CEP128 centrosomal protein 128kDa 0.0262581
PDIA4 protein disulfide isomerase family A, member 4 0.0262342
TANGO6 transport and golgi organization 6 homolog (Drosophila) 0.0261276
JMJD1C jumonji domain containing 1C 0.0260771
LMBR1 limb development membrane protein 1 0.0258625
ADGRA3 adhesion G protein-coupled receptor A3 0.0257178
RPS16 ribosomal protein S16 0.0256593
NCKAP1 NCK-associated protein 1 0.0255464
NPEPPS aminopeptidase puromycin sensitive 0.025542
KCTD1 potassium channel tetramerization domain containing 1 0.0255275
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0255165
CAND1 cullin-associated and neddylation-dissociated 1 0.0255132
HIPK2 homeodomain interacting protein kinase 2 0.0254536
PHF14 PHD finger protein 14 0.0253764
LRIF1 ligand dependent nuclear receptor interacting factor 1 0.0253629
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.0252982
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0251899
TMEM245 transmembrane protein 245 0.0251391
PHACTR4 phosphatase and actin regulator 4 0.0249758
FBXO11 F-box protein 11 0.0249473
ACLY ATP citrate lyase 0.0248451
CUL5 cullin 5 0.0248032
ATXN10 ataxin 10 0.0246264
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0244536
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.0244362
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0240217
RFWD3 ring finger and WD repeat domain 3 0.0238979
CKAP4 cytoskeleton-associated protein 4 0.0238842
PLEKHA6 pleckstrin homology domain containing, family A member 6 0.0238469
FOSL1 FOS-like antigen 1 0.023763
NCOA7 nuclear receptor coactivator 7 0.0236904
CDK17 cyclin-dependent kinase 17 0.0235511
ATAD2 ATPase family, AAA domain containing 2 0.0235006
HACD3 3-hydroxyacyl-CoA dehydratase 3 0.0234651
RNFT2 ring finger protein, transmembrane 2 0.0234602
PIAS1 protein inhibitor of activated STAT, 1 0.0233703
NOL10 nucleolar protein 10 0.0233537
CYRIB CYFIP related Rac1 interactor B 0.0233283
ATXN7L1 ataxin 7-like 1 0.0233249
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0232704
CCNT1 cyclin T1 0.0232611
NAMPT nicotinamide phosphoribosyltransferase 0.0231926
CKAP5 cytoskeleton associated protein 5 0.0231632
SMIM44 small integral membrane protein 44 0.0231447
RPS6 ribosomal protein S6 0.0231078
DHRS7B dehydrogenase/reductase (SDR family) member 7B 0.0230717
SIL1 SIL1 nucleotide exchange factor 0.0230216
TPI1 triosephosphate isomerase 1 0.0229375
KPNB1 karyopherin (importin) beta 1 0.0228962
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0228364
USP3 ubiquitin specific peptidase 3 0.0228008
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0227814
LIMS1 LIM and senescent cell antigen-like domains 1 0.0227741
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0226386
AK1 adenylate kinase 1 0.0226208
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.0224397
SLC31A1 solute carrier family 31 (copper transporter), member 1 0.0224327
RPL23 ribosomal protein L23 0.0221664
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 0.0221395
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0221231
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0221036
MBNL1 muscleblind-like splicing regulator 1 0.0220393
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 0.0219343
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.0218789
GPR39 G protein-coupled receptor 39 0.0218753
CENPI centromere protein I 0.0218615
KIF5B kinesin family member 5B 0.0218161
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0218114
AUTS2 autism susceptibility candidate 2 0.0217886
DNM2 dynamin 2 0.0217858
KIDINS220 kinase D-interacting substrate, 220kDa 0.0217853
RTN4 reticulon 4 0.0217027
PALS1 protein associated with LIN7 1, MAGUK p55 family member 0.0216052
CCNT2 cyclin T2 0.0215087
MUSK muscle, skeletal, receptor tyrosine kinase 0.0214869
FOXK2 forkhead box K2 0.0214695
TPM3 tropomyosin 3 0.0214009
ZNRF3 zinc and ring finger 3 0.0213779
TRIO trio Rho guanine nucleotide exchange factor 0.0213461
SSH2 slingshot protein phosphatase 2 0.0213322
CSE1L CSE1 chromosome segregation 1-like (yeast) 0.0213264
TMSB10 thymosin beta 10 0.0213215
RPS8 ribosomal protein S8 0.0213179
PHKB phosphorylase kinase, beta 0.0211458
GPBP1 GC-rich promoter binding protein 1 0.0211297
AKR1C1 aldo-keto reductase family 1, member C1 0.0210644
NUDC nudC nuclear distribution protein 0.0210628
PANK2 pantothenate kinase 2 0.0210583
RNASEH1 ribonuclease H1 0.0209038
DHDDS dehydrodolichyl diphosphate synthase 0.0208786
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 0.0208619
ZNF638 zinc finger protein 638 0.020849
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0208319
IPO7 importin 7 0.0207311
SET SET nuclear proto-oncogene 0.0207144
RPL13A ribosomal protein L13a 0.0207117
HAT1 histone acetyltransferase 1 0.0206297
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 0.0206158
RPL5 ribosomal protein L5 0.0205804
SMC1A structural maintenance of chromosomes 1A 0.0205411
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0205375
ELOVL5 ELOVL fatty acid elongase 5 0.0205215
ARHGAP18 Rho GTPase activating protein 18 0.0204516
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.02045
NCOA2 nuclear receptor coactivator 2 0.0204363
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0201557
EIF4E eukaryotic translation initiation factor 4E 0.0201185
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.0201138
PDZD8 PDZ domain containing 8 0.020081
SAMD1 sterile alpha motif domain containing 1 0.0200725
BRCC3 BRCA1/BRCA2-containing complex, subunit 3 0.020043
ADGRG6 adhesion G protein-coupled receptor G6 0.0200087
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 0.0199456
KCMF1 potassium channel modulatory factor 1 0.0199079
MTMR3 myotubularin related protein 3 0.0199041
BMPR1A bone morphogenetic protein receptor, type IA 0.0198858
COPS3 COP9 signalosome subunit 3 0.0198742
AATF apoptosis antagonizing transcription factor 0.0198296
SMC4 structural maintenance of chromosomes 4 0.0197931
UBE3A ubiquitin protein ligase E3A 0.0197673
CHD4 chromodomain helicase DNA binding protein 4 0.0196825
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.0196761
MAPK1 mitogen-activated protein kinase 1 0.0196722
PARN poly(A)-specific ribonuclease 0.0196412
SH3PXD2A SH3 and PX domains 2A 0.0196276
DNM3 dynamin 3 0.019468
EDN1 endothelin 1 0.0194216
PALLD palladin, cytoskeletal associated protein 0.0193755
KDM6A lysine (K)-specific demethylase 6A 0.0193716
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0193629
PPP4R3A protein phosphatase 4 regulatory subunit 3A 0.0193495
CLPTM1 cleft lip and palate associated transmembrane protein 1 0.0193331
CENPE centromere protein E, 312kDa 0.0193278
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 0.0191734
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.019161
TRAPPC9 trafficking protein particle complex 9 0.019131
SUZ12 SUZ12 polycomb repressive complex 2 subunit 0.0191059
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) 0.0190676
BPTF bromodomain PHD finger transcription factor 0.0190656
ERCC3 excision repair cross-complementation group 3 0.0190053
GLI2 GLI family zinc finger 2 0.0189942
PDIA6 protein disulfide isomerase family A, member 6 0.0189392
UBA2 ubiquitin-like modifier activating enzyme 2 0.018924
SETX senataxin 0.0189059
ENAH enabled homolog (Drosophila) 0.0187687
BRI3BP BRI3 binding protein 0.0187576
RPL39 ribosomal protein L39 0.0187446
CCDC91 coiled-coil domain containing 91 0.0187072
H3-3B H3.3 histone B 0.0186424
TBC1D22A TBC1 domain family, member 22A 0.0186224
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 0.0185626
RPS19 ribosomal protein S19 0.0185568
MVP major vault protein 0.0185207
ANLN anillin, actin binding protein 0.0185119
S100A6 S100 calcium binding protein A6 0.0184779
CD109 CD109 molecule 0.0184694
CCDC14 coiled-coil domain containing 14 0.0183805
MYO1B myosin IB 0.0183394
CEMIP2 cell migration inducing hyaluronidase 2 0.0183244
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 0.0183202
TNS3 tensin 3 0.0183071
RPL12 ribosomal protein L12 0.0182626
PLCH1 phospholipase C, eta 1 0.0182332
EREG epiregulin 0.0181582
RBMS2 RNA binding motif, single stranded interacting protein 2 0.0181533
CNTNAP3 contactin associated protein-like 3 0.0181407
TSPAN15 tetraspanin 15 0.0181338
HEATR1 HEAT repeat containing 1 0.0181214
SRPK1 SRSF protein kinase 1 0.0181059
NXPE3 neurexophilin and PC-esterase domain family, member 3 0.0180828
CEP85 centrosomal protein 85kDa 0.0180637
GSTCD glutathione S-transferase, C-terminal domain containing 0.0180633
CTSD cathepsin D 0.018012
ANXA2 annexin A2 0.0179272
UIMC1 ubiquitin interaction motif containing 1 0.0179057
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0179041
ZNF800 zinc finger protein 800 0.0178919
SPPL3 signal peptide peptidase like 3 0.0178617
PCLAF PCNA clamp associated factor 0.0178556
BLM Bloom syndrome, RecQ helicase-like 0.0178516
PCNP PEST proteolytic signal containing nuclear protein 0.0177878
JPT1 Jupiter microtubule associated homolog 1 0.0177651
ADAM9 ADAM metallopeptidase domain 9 0.0177428
CSNK1D casein kinase 1, delta 0.0177294
MYOF myoferlin 0.0177253
MYEOV myeloma overexpressed 0.0177243
FBXL17 F-box and leucine-rich repeat protein 17 0.0176829
NCAPG2 non-SMC condensin II complex, subunit G2 0.0176807
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0176572
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0175712
CD81 CD81 molecule 0.0175492
AFTPH aftiphilin 0.0175268
COP1 COP1 E3 ubiquitin ligase 0.0174681
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0174636
FOXM1 forkhead box M1 0.0174555
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 0.0174377
PCDH9 protocadherin 9 0.017382
MRTFB myocardin related transcription factor B 0.0172463
HDGF hepatoma-derived growth factor 0.0172238
HSDL2 hydroxysteroid dehydrogenase like 2 0.0172032
RABGAP1 RAB GTPase activating protein 1 0.0171539
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0171366
SLC35F3 solute carrier family 35, member F3 0.0170818
PBX3 pre-B-cell leukemia homeobox 3 0.0170421
MCM8 minichromosome maintenance complex component 8 0.0170006
APLP2 amyloid beta (A4) precursor-like protein 2 0.0169804
TBC1D4 TBC1 domain family, member 4 0.0169455
TCERG1 transcription elongation regulator 1 0.0169132
ZNF367 zinc finger protein 367 0.0168766
DMTN dematin actin binding protein 0.0168232
ENO1 enolase 1, (alpha) 0.0168138
IPO9 importin 9 0.0167934
DDB1 damage-specific DNA binding protein 1, 127kDa 0.0167718
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0167525
ABHD2 abhydrolase domain containing 2 0.0167339
CLSPN claspin 0.0167337
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.0167306
IER3 immediate early response 3 0.016695
EML4 echinoderm microtubule associated protein like 4 0.016689
CAPRIN1 cell cycle associated protein 1 0.0166517
CHLSN cholesin 0.0166399
RSRC1 arginine/serine-rich coiled-coil 1 0.0166178
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 0.0165316
IGFBP3 insulin-like growth factor binding protein 3 0.0165296
TUBA1B tubulin, alpha 1b 0.0165288
NF1 neurofibromin 1 0.0165074
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.0164944
HMGA1 high mobility group AT-hook 1 0.0164326
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.0163691
CCDC137 coiled-coil domain containing 137 0.0163685
AQP3 aquaporin 3 (Gill blood group) 0.016367
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0163579
TRAF3 TNF receptor-associated factor 3 0.0163508
DOCK10 dedicator of cytokinesis 10 0.0162845
EPDR1 ependymin related 1 0.0162822
WWP1 WW domain containing E3 ubiquitin protein ligase 1 0.0162746
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 0.0162586
NOP56 NOP56 ribonucleoprotein 0.0162179
RAD21 RAD21 homolog (S. pombe) 0.0162098
FERMT2 fermitin family member 2 0.0162025
TBK1 TANK-binding kinase 1 0.0161845
PRELID2 PRELI domain containing 2 0.0161815
STAU1 staufen double-stranded RNA binding protein 1 0.0161708
RBL1 retinoblastoma-like 1 0.0161265
DNA2 DNA replication helicase/nuclease 2 0.0161046
IL1R1 interleukin 1 receptor, type I 0.0161014
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0160929
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.0160854
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0160711
PRDX5 peroxiredoxin 5 0.0160621
KIF18B kinesin family member 18B 0.0160522
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0160505
GSR glutathione reductase 0.0160326
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.0159767
EMP2 epithelial membrane protein 2 0.0159734
C6ORF62 chromosome 6 open reading frame 62 0.0159401
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0158509
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 0.0158508
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 0.0157869
EP400 E1A binding protein p400 0.0157468
AQR aquarius intron-binding spliceosomal factor 0.0157051
WDR73 WD repeat domain 73 0.0157018
CD320 CD320 molecule 0.0156911
ABI2 abl-interactor 2 0.015665
RNF10 ring finger protein 10 0.0156459
TTC27 tetratricopeptide repeat domain 27 0.0156374
NCAPD3 non-SMC condensin II complex, subunit D3 0.0156031
ATAD1 ATPase family, AAA domain containing 1 0.0155913
TNRC6A trinucleotide repeat containing 6A 0.0155195
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) 0.0154959
MAP2K3 mitogen-activated protein kinase kinase 3 0.015467
C1QBP complement component 1, q subcomponent binding protein 0.0154533
BLVRB biliverdin reductase B 0.015435
CDC123 cell division cycle 123 0.0154107
SERTAD2 SERTA domain containing 2 0.0153872
RC3H2 ring finger and CCCH-type domains 2 0.01537
SLC35E3 solute carrier family 35, member E3 0.0153313
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 0.0152942
TMEM131 transmembrane protein 131 0.0152838
ADD1 adducin 1 (alpha) 0.0151881
RPL31 ribosomal protein L31 0.0151863
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.0151773
FBXO36 F-box protein 36 0.0151554
DHCR7 7-dehydrocholesterol reductase 0.0151216
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) 0.0151194
KIF14 kinesin family member 14 0.0150874
DAPK1 death-associated protein kinase 1 0.0150381
YLPM1 YLP motif containing 1 0.015016
MB21D2 Mab-21 domain containing 2 0.014985
NSUN2 NOP2/Sun RNA methyltransferase family, member 2 0.0149607
RACGAP1 Rac GTPase activating protein 1 0.0149569
USP1 ubiquitin specific peptidase 1 0.0149036
AREG amphiregulin 0.0149018
APOO apolipoprotein O 0.0148931
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 0.0148901
PLS1 plastin 1 0.014878
SLC38A10 solute carrier family 38, member 10 0.0148358
KIAA1328 KIAA1328 0.0147714
PLCB4 phospholipase C, beta 4 0.0147585
UBE2D2 ubiquitin-conjugating enzyme E2D 2 0.014755
IGSF1 immunoglobulin superfamily, member 1 0.0147516
PHF21A PHD finger protein 21A 0.0147326
ELMO1 engulfment and cell motility 1 0.0147315
MBOAT7 membrane bound O-acyltransferase domain containing 7 0.0147028
ZFAND5 zinc finger, AN1-type domain 5 0.0146884
ITM2B integral membrane protein 2B 0.0146827
EXOSC6 exosome component 6 0.01468
GNAS GNAS complex locus 0.0146761
SUMF2 sulfatase modifying factor 2 0.0146514
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 0.0146359
EIF5B eukaryotic translation initiation factor 5B 0.0146331
MYPOP Myb-related transcription factor, partner of profilin 0.0146152
LY6E lymphocyte antigen 6 complex, locus E 0.0146078
UBB ubiquitin B 0.0145404
CRTC1 CREB regulated transcription coactivator 1 0.0145276
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0145054
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial) 0.0144152
ANXA4 annexin A4 0.0144134
RPS21 ribosomal protein S21 0.0144107
ARHGAP32 Rho GTPase activating protein 32 0.0143973
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0143923
SFPQ splicing factor proline/glutamine-rich 0.0143816
BCAT2 branched chain amino-acid transaminase 2, mitochondrial 0.0143594
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0143523
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae) 0.0143459
EPB41 erythrocyte membrane protein band 4.1 0.0143407
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0143388
AUP1 ancient ubiquitous protein 1 0.014327
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0143177
WDR72 WD repeat domain 72 0.0143091
FLOT1 flotillin 1 0.0142935
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0142844
KNTC1 kinetochore associated 1 0.0142606
UBQLN1 ubiquilin 1 0.0142498
ATF7IP2 activating transcription factor 7 interacting protein 2 0.0142471
NOP58 NOP58 ribonucleoprotein 0.0142195
ATF7IP activating transcription factor 7 interacting protein 0.0141809
ADGRV1 adhesion G protein-coupled receptor V1 0.0141776
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) 0.0141766
RAI1 retinoic acid induced 1 0.0141528
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0140867
MZT2A mitotic spindle organizing protein 2A 0.0140848
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0140788
SCAPER S-phase cyclin A-associated protein in the ER 0.014058
MTF2 metal response element binding transcription factor 2 0.0139876
PRRC2C proline-rich coiled-coil 2C 0.0139732
METTL2A methyltransferase like 2A 0.0139612
GXYLT1 glucoside xylosyltransferase 1 0.0139553
BHLHE40 basic helix-loop-helix family, member e40 0.0139499
FADS2 fatty acid desaturase 2 0.0139494
NUP107 nucleoporin 107kDa 0.0139387
STX2 syntaxin 2 0.0139383
EIF4B eukaryotic translation initiation factor 4B 0.013936
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 0.0139208
CFAP44 cilia and flagella associated protein 44 0.0138898
CD2AP CD2-associated protein 0.0138839
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0138786
ADNP2 ADNP homeobox 2 0.0138727
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0138704
TUFM Tu translation elongation factor, mitochondrial 0.0138677
TMEM167A transmembrane protein 167A 0.0138627
MMS22L MMS22-like, DNA repair protein 0.0138425
ANKRD30A ankyrin repeat domain 30A 0.0138218
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0137648
RBBP7 retinoblastoma binding protein 7 0.0137533
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0137318
TRIM9 tripartite motif containing 9 0.013706
CANT1 calcium activated nucleotidase 1 0.0136886
SOX6 SRY (sex determining region Y)-box 6 0.013671
GPC1 glypican 1 0.0136603
NAP1L1 nucleosome assembly protein 1-like 1 0.0136464
SNX5 sorting nexin 5 0.0136148
SFXN1 sideroflexin 1 0.0135964
LRP5 low density lipoprotein receptor-related protein 5 0.0135917
ZNFX1 zinc finger, NFX1-type containing 1 0.0135884
LYN LYN proto-oncogene, Src family tyrosine kinase 0.0135876
TASP1 taspase, threonine aspartase, 1 0.0135849
MIS18BP1 MIS18 binding protein 1 0.0135547
URI1 URI1, prefoldin-like chaperone 0.0135163
PDS5B PDS5 cohesin associated factor B 0.013472
CHAF1A chromatin assembly factor 1, subunit A (p150) 0.0134593
SF3A3 splicing factor 3a, subunit 3, 60kDa 0.0134554
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0134419
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0134332
ZNF789 zinc finger protein 789 0.0134205
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34 0.0133584
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.0133523
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 0.0133295
GPATCH2 G patch domain containing 2 0.0133213
THUMPD2 THUMP domain containing 2 0.0133152
DIAPH1 diaphanous-related formin 1 0.01331
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0133081
USP49 ubiquitin specific peptidase 49 0.0132977
ZNF124 zinc finger protein 124 0.0132917
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 0.0132298
ZFP36L1 ZFP36 ring finger protein-like 1 0.0132236
ZCCHC2 zinc finger, CCHC domain containing 2 0.0131925
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.0131727
CKAP2L cytoskeleton associated protein 2-like 0.0131627
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.0131182
HMGN1 high mobility group nucleosome binding domain 1 0.0131145
CRK v-crk avian sarcoma virus CT10 oncogene homolog 0.0131085
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 0.0130816
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0130711
MTMR2 myotubularin related protein 2 0.0130589
ELOVL6 ELOVL fatty acid elongase 6 0.0130445
FBXW11 F-box and WD repeat domain containing 11 0.0130432
MCM10 minichromosome maintenance complex component 10 0.0130325

decreased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A -0.140213
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.113622
KRT81 keratin 81, type II -0.10976
KYNU kynureninase -0.092319
CLU clusterin -0.0815513
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0809355
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.07818
CNTN1 contactin 1 -0.0769089
MYO10 myosin X -0.0686149
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0668675
MYO1E myosin IE -0.0654783
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0652842
PDE4D phosphodiesterase 4D, cAMP-specific -0.062541
ACTN4 actinin, alpha 4 -0.0608784
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.0604161
THSD7A thrombospondin, type I, domain containing 7A -0.0604097
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0590371
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0590038
HIP1 huntingtin interacting protein 1 -0.0572562
EHBP1 EH domain binding protein 1 -0.0570515
MSI2 musashi RNA-binding protein 2 -0.0561782
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0549738
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -0.0547404
MED13L mediator complex subunit 13-like -0.0545164
EFNA5 ephrin-A5 -0.0529903
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0520836
GPX2 glutathione peroxidase 2 -0.0511598
CNTNAP3B contactin associated protein-like 3B -0.0504227
BCL2L1 BCL2-like 1 -0.0486998
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0484367
IGF1R insulin-like growth factor 1 receptor -0.0472789
SQSTM1 sequestosome 1 -0.0469255
PRKCSH protein kinase C substrate 80K-H -0.0466314
PATJ PATJ crumbs cell polarity complex component -0.0464055
TNRC6B trinucleotide repeat containing 6B -0.0456109
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0452241
TNRC18 trinucleotide repeat containing 18 -0.0447348
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0439967
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -0.0435747
FBXL20 F-box and leucine-rich repeat protein 20 -0.0429181
LRP10 low density lipoprotein receptor-related protein 10 -0.0420973
RNF145 ring finger protein 145 -0.041278
GMDS GDP-mannose 4,6-dehydratase -0.0407701
SMAD2 SMAD family member 2 -0.0403432
PTGR1 prostaglandin reductase 1 -0.0402778
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0399429
WWTR1 WW domain containing transcription regulator 1 -0.0390485
CP ceruloplasmin (ferroxidase) -0.0390395
RACK1 receptor for activated C kinase 1 -0.03861
MAP7 microtubule-associated protein 7 -0.0383046
LARP1 La ribonucleoprotein domain family, member 1 -0.0374185
PDE8A phosphodiesterase 8A -0.0373892
FHIT fragile histidine triad -0.0373679
ARHGAP26 Rho GTPase activating protein 26 -0.0368445
VCL vinculin -0.0365201
GOLGA4 golgin A4 -0.0365127
THSD4 thrombospondin, type I, domain containing 4 -0.0363789
BASP1 brain abundant, membrane attached signal protein 1 -0.0363442
VMP1 vacuole membrane protein 1 -0.0356058
JUP junction plakoglobin -0.0355433
SOS1 son of sevenless homolog 1 (Drosophila) -0.0355172
EZR ezrin -0.0352982
RERE arginine-glutamic acid dipeptide (RE) repeats -0.03496
KRT7 keratin 7, type II -0.0348124
FRMD3 FERM domain containing 3 -0.0345563
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 -0.0341415
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.0340813
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0340608
SETBP1 SET binding protein 1 -0.0339331
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0337987
CLIP2 CAP-GLY domain containing linker protein 2 -0.0337794
DOCK5 dedicator of cytokinesis 5 -0.0337276
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0336849
PM20D1 peptidase M20 domain containing 1 -0.0335483
BRD4 bromodomain containing 4 -0.0335364
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) -0.0335094
NT5C2 5'-nucleotidase, cytosolic II -0.0332722
ZBTB20 zinc finger and BTB domain containing 20 -0.033064
PCNX2 pecanex 2 -0.0329112
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0326462
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.032643
AGR2 anterior gradient 2 -0.0323362
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0322058
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -0.0321932
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0321708
HOMER2 homer scaffolding protein 2 -0.0320737
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0320472
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0312344
ARL15 ADP-ribosylation factor-like 15 -0.0307072
CANX calnexin -0.030691
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) -0.0306865
SYT1 synaptotagmin I -0.0306566
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0304018
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 -0.0303872
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 -0.0303643
PDLIM5 PDZ and LIM domain 5 -0.0303072
PRKCE protein kinase C, epsilon -0.0301756
SVIL supervillin -0.0298801
PKM pyruvate kinase, muscle -0.0296218
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.029452
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0293068
EVA1C eva-1 homolog C (C. elegans) -0.0291037
KIF13B kinesin family member 13B -0.0290749
DUSP16 dual specificity phosphatase 16 -0.0286358
FAF2 Fas associated factor family member 2 -0.0284363
SLC38A2 solute carrier family 38, member 2 -0.0284217
FBXO17 F-box protein 17 -0.0282133
FGA fibrinogen alpha chain -0.0281386
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0280199
PCED1B PC-esterase domain containing 1B -0.0279758
TBL1X transducin (beta)-like 1X-linked -0.0278764
CST3 cystatin C -0.0275017
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 -0.0274802
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0271163
BCAS3 breast carcinoma amplified sequence 3 -0.0271074
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 -0.0270369
RAB1A RAB1A, member RAS oncogene family -0.0267964
ACBD3 acyl-CoA binding domain containing 3 -0.0266158
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.026539
FGG fibrinogen gamma chain -0.0264056
MYO1D myosin ID -0.026284
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0261121
SRPK2 SRSF protein kinase 2 -0.0260528
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 -0.0260346
GIPC1 GIPC PDZ domain containing family, member 1 -0.0259627
TP63 tumor protein p63 -0.0259575
RSL1D1 ribosomal L1 domain containing 1 -0.0258256
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 -0.0257812
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0257314
BABAM2 BRISC and BRCA1 A complex member 2 -0.0255869
FGFR1 fibroblast growth factor receptor 1 -0.0254216
GOLPH3 golgi phosphoprotein 3 (coat-protein) -0.0252167
KDM4C lysine (K)-specific demethylase 4C -0.025003
KANK1 KN motif and ankyrin repeat domains 1 -0.0249041
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) -0.0248921
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) -0.0247845
CLIP1 CAP-GLY domain containing linker protein 1 -0.0247746
SEC11A SEC11 homolog A (S. cerevisiae) -0.0247024
TACC1 transforming, acidic coiled-coil containing protein 1 -0.0246177
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) -0.0246096
CALD1 caldesmon 1 -0.0244025
MYO18A myosin XVIIIA -0.0242125
DSPP dentin sialophosphoprotein -0.0241082
TACC2 transforming, acidic coiled-coil containing protein 2 -0.0240927
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -0.0238327
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0238228
NBAS neuroblastoma amplified sequence -0.0237963
SLC44A1 solute carrier family 44 (choline transporter), member 1 -0.0237577
RBPMS RNA binding protein with multiple splicing -0.0236867
KDM5B lysine (K)-specific demethylase 5B -0.0236414
NFIA nuclear factor I/A -0.0236219
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0234771
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0234571
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0233381
NRG1 neuregulin 1 -0.0231035
CD44 CD44 molecule (Indian blood group) -0.0230837
POTEF POTE ankyrin domain family, member F -0.0230084
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.022906
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0228105
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0227943
FLNA filamin A, alpha -0.0227601
USP53 ubiquitin specific peptidase 53 -0.0226419
GPRIN3 GPRIN family member 3 -0.0224482
GRAMD1A GRAM domain containing 1A -0.0223491
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.022346
MED13 mediator complex subunit 13 -0.0223111
DENND1A DENN/MADD domain containing 1A -0.022285
RILPL1 Rab interacting lysosomal protein-like 1 -0.0222822
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0221756
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0221183
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0220953
USP32 ubiquitin specific peptidase 32 -0.0220406
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A -0.0220404
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.0220103
TENT2 terminal nucleotidyltransferase 2 -0.0218759
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 -0.0217657
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0216533
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0215374
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) -0.0214688
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0214203
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) -0.0213
ADAR adenosine deaminase, RNA-specific -0.0212838
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0212765
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -0.0212721
TM4SF20 transmembrane 4 L six family member 20 -0.0212587
TCF12 transcription factor 12 -0.0211925
IRS2 insulin receptor substrate 2 -0.0211493
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0210342
DNAAF9 dynein axonemal assembly factor 9 -0.0210317
DENND5B DENN/MADD domain containing 5B -0.0209505
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) -0.0209002
OPHN1 oligophrenin 1 -0.020848
RBM6 RNA binding motif protein 6 -0.020833
DYM dymeclin -0.0207122
PPP1R9A protein phosphatase 1, regulatory subunit 9A -0.0206782
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0206054
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.020535
TBC1D14 TBC1 domain family, member 14 -0.0204921
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0203465
CHD9 chromodomain helicase DNA binding protein 9 -0.020343
CPEB2 cytoplasmic polyadenylation element binding protein 2 -0.0203323
FMN1 formin 1 -0.0201932
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0201616
HGD homogentisate 1,2-dioxygenase -0.0201282
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0201004
CALCOCO2 calcium binding and coiled-coil domain 2 -0.0200852
CFH complement factor H -0.0200211
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0199348
AHCYL2 adenosylhomocysteinase-like 2 -0.0198058
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.019576
CHD7 chromodomain helicase DNA binding protein 7 -0.0195697
TMEM51 transmembrane protein 51 -0.01954
TANK TRAF family member-associated NFKB activator -0.0194471
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) -0.0194094
TRAM1 translocation associated membrane protein 1 -0.0193125
PDE7A phosphodiesterase 7A -0.019307
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 -0.019251
LMNA lamin A/C -0.0191773
PPARG peroxisome proliferator-activated receptor gamma -0.0191108
DIS3L2 DIS3 like 3'-5' exoribonuclease 2 -0.0190316
KHDC4 KH domain containing 4, pre-mRNA splicing factor -0.0188663
CPLX2 complexin 2 -0.0187886
UBAP2 ubiquitin associated protein 2 -0.0187869
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0187369
R3HDM1 R3H domain containing 1 -0.0186963
ANXA11 annexin A11 -0.0186156
MISP mitotic spindle positioning -0.0185798
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0185729
RUVBL2 RuvB-like AAA ATPase 2 -0.0185688
ABHD12 abhydrolase domain containing 12 -0.0184213
PBRM1 polybromo 1 -0.0184187
MGST1 microsomal glutathione S-transferase 1 -0.0183508
CLTA clathrin, light chain A -0.0181988
SKIL SKI-like proto-oncogene -0.0181273
BUD23 BUD23 rRNA methyltransferase and ribosome maturation factor -0.0181207
ETFA electron-transfer-flavoprotein, alpha polypeptide -0.0181152
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic) -0.0179902
CEP350 centrosomal protein 350kDa -0.0179183
NEK9 NIMA-related kinase 9 -0.017823
PHKA2 phosphorylase kinase, alpha 2 (liver) -0.0177341
NEB nebulin -0.0176991
GGNBP2 gametogenetin binding protein 2 -0.0175598
EIF3B eukaryotic translation initiation factor 3, subunit B -0.0175499
MYO15B myosin XVB -0.0174914
CUL3 cullin 3 -0.0174581
USP47 ubiquitin specific peptidase 47 -0.0174451
BCAS1 breast carcinoma amplified sequence 1 -0.0174183
NEO1 neogenin 1 -0.0174123
DMXL2 Dmx-like 2 -0.0174107
ASPH aspartate beta-hydroxylase -0.0174085
LMAN1 lectin, mannose-binding, 1 -0.0174014
ZNF33A zinc finger protein 33A -0.0173922
CLDN2 claudin 2 -0.0173411
FAM168A family with sequence similarity 168, member A -0.017335
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.0172664
PPP6R2 protein phosphatase 6, regulatory subunit 2 -0.0172488
CMTM8 CKLF-like MARVEL transmembrane domain containing 8 -0.0172432
TALDO1 transaldolase 1 -0.0172355
MARK2 MAP/microtubule affinity-regulating kinase 2 -0.0172112
MYLK myosin light chain kinase -0.017157
LITAF lipopolysaccharide-induced TNF factor -0.0170529
EIF3K eukaryotic translation initiation factor 3, subunit K -0.0170411
NNMT nicotinamide N-methyltransferase -0.0169467
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0169094
COL4A4 collagen, type IV, alpha 4 -0.0169006
AVL9 AVL9 homolog (S. cerevisiase) -0.0168793
SYAP1 synapse associated protein 1 -0.0168479
TMEM164 transmembrane protein 164 -0.0168325
BOD1L1 biorientation of chromosomes in cell division 1-like 1 -0.0168048
TAOK3 TAO kinase 3 -0.0167485
UTRN utrophin -0.0167479
BMP6 bone morphogenetic protein 6 -0.0167377
IFT74 intraflagellar transport 74 -0.016734
MTFR1 mitochondrial fission regulator 1 -0.0167225
SMOC1 SPARC related modular calcium binding 1 -0.016702
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0166923
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0166615
SETD5 SET domain containing 5 -0.0166187
CD151 CD151 molecule (Raph blood group) -0.0165909
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0165883
CCDC88A coiled-coil domain containing 88A -0.0165859
KIZ kizuna centrosomal protein -0.0165653
PHYKPL 5-phosphohydroxy-L-lysine phospho-lyase -0.0165092
RBMX RNA binding motif protein, X-linked -0.0165049
ZNF461 zinc finger protein 461 -0.0164608
TADA2A transcriptional adaptor 2A -0.0164396
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0163935
GRAMD1B GRAM domain containing 1B -0.0163559
PELI2 pellino E3 ubiquitin protein ligase family member 2 -0.0163115
SANBR SANT and BTB domain regulator of CSR -0.0163021
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0163002
USP36 ubiquitin specific peptidase 36 -0.0162743
INVS inversin -0.0162227
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0161903
PHF3 PHD finger protein 3 -0.0161828
BLTP3B bridge-like lipid transfer protein family member 3B -0.0161291
TMEM65 transmembrane protein 65 -0.0161219
FAM107B family with sequence similarity 107, member B -0.0161015
ATOSA atos homolog A -0.016087
WDR26 WD repeat domain 26 -0.0160668
NUP98 nucleoporin 98kDa -0.0160442
LTBP4 latent transforming growth factor beta binding protein 4 -0.0160421
CCND3 cyclin D3 -0.0159927
TNPO1 transportin 1 -0.0159498
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0159478
SMAD6 SMAD family member 6 -0.0159197
WDR35 WD repeat domain 35 -0.0159123
SDCCAG8 serologically defined colon cancer antigen 8 -0.0159104
AXL AXL receptor tyrosine kinase -0.0158953
RPS4X ribosomal protein S4, X-linked -0.015895
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 -0.0158725
PELP1 proline, glutamate and leucine rich protein 1 -0.0158721
UNC13A unc-13 homolog A (C. elegans) -0.0158696
HM13 histocompatibility (minor) 13 -0.0158542
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -0.015837
RIN2 Ras and Rab interactor 2 -0.015821
CUL4A cullin 4A -0.0157538
LCOR ligand dependent nuclear receptor corepressor -0.0157444
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like -0.0157259
VPS35L VPS35 endosomal protein sorting factor like -0.0157138
ZFYVE16 zinc finger, FYVE domain containing 16 -0.0156854
ZFAND6 zinc finger, AN1-type domain 6 -0.0156648
MEF2A myocyte enhancer factor 2A -0.0156421
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.015576
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 -0.0155595
GALK2 galactokinase 2 -0.0155508
ALS2 amyotrophic lateral sclerosis 2 (juvenile) -0.0155137
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 -0.0154758
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) -0.0154087
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked -0.0154084
FNDC3B fibronectin type III domain containing 3B -0.0153972
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin -0.0153685
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 -0.0153401
WIPF1 WAS/WASL interacting protein family, member 1 -0.0153175
LAMP2 lysosomal-associated membrane protein 2 -0.0153049
PCNX1 pecanex 1 -0.0152953
SOX9 SRY (sex determining region Y)-box 9 -0.0152896
CDK12 cyclin-dependent kinase 12 -0.0151477
BRWD3 bromodomain and WD repeat domain containing 3 -0.0151259
SREBF1 sterol regulatory element binding transcription factor 1 -0.0150686
PCGF6 polycomb group ring finger 6 -0.0150563
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa -0.0150429
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0150286
LUC7L LUC7-like (S. cerevisiae) -0.0150249
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -0.0150049
SEC63 SEC63 homolog (S. cerevisiae) -0.0149893
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0149673
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial -0.0149498
LAMA5 laminin, alpha 5 -0.0149496
C2CD5 C2 calcium-dependent domain containing 5 -0.0149448
NUP155 nucleoporin 155kDa -0.0149415
NOSTRIN nitric oxide synthase trafficking -0.0149353
ZNF251 zinc finger protein 251 -0.0149245
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa -0.0148591
FCGBP Fc fragment of IgG binding protein -0.014852
RBM39 RNA binding motif protein 39 -0.0148084
UBE2H ubiquitin-conjugating enzyme E2H -0.0147959
HEATR5A HEAT repeat containing 5A -0.0147498
PUS7 pseudouridylate synthase 7 (putative) -0.0147301
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 -0.0147206
CD46 CD46 molecule, complement regulatory protein -0.014708
NFX1 nuclear transcription factor, X-box binding 1 -0.0147061
SNX4 sorting nexin 4 -0.0146829
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0146541
DPP9 dipeptidyl-peptidase 9 -0.0146481
C2ORF42 chromosome 2 open reading frame 42 -0.0146229
ATXN3 ataxin 3 -0.0146184
PDXK pyridoxal (pyridoxine, vitamin B6) kinase -0.0145989
ETV6 ets variant 6 -0.0145932
TBCE tubulin folding cofactor E -0.0145637
WWP2 WW domain containing E3 ubiquitin protein ligase 2 -0.0145314
OSBPL9 oxysterol binding protein-like 9 -0.0145313
PRTG protogenin -0.0144849
GPATCH2L G patch domain containing 2-like -0.0144711
CDR2 cerebellar degeneration-related protein 2, 62kDa -0.0144688
SHLD1 shieldin complex subunit 1 -0.0144668
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0144517
PRDX1 peroxiredoxin 1 -0.0144402
LATS1 large tumor suppressor kinase 1 -0.0143999
PRPF3 pre-mRNA processing factor 3 -0.0143983
SYMPK symplekin -0.0143816
TMEM87A transmembrane protein 87A -0.0143678
R3HDM2 R3H domain containing 2 -0.0143606
CD63 CD63 molecule -0.0143439
DCTN1 dynactin 1 -0.0143433
TMEM41B transmembrane protein 41B -0.0143397
DENND11 DENN domain containing 11 -0.0143391
NUDCD3 NudC domain containing 3 -0.0143177
MPRIP myosin phosphatase Rho interacting protein -0.0142974
IKBIP IKBKB interacting protein -0.0142933
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0142893
AGO2 argonaute RISC catalytic component 2 -0.0142148
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0141948
SNW1 SNW domain containing 1 -0.0141659
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0141491
TPR translocated promoter region, nuclear basket protein -0.0141442
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0141054
CCNI cyclin I -0.0140872
SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 -0.0140788
TCF25 transcription factor 25 (basic helix-loop-helix) -0.0140464
SCAF11 SR-related CTD-associated factor 11 -0.0140397
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1 -0.0140208
TXNDC15 thioredoxin domain containing 15 -0.0140165
FOXP1 forkhead box P1 -0.0139916
PARD3 par-3 family cell polarity regulator -0.0139836
NTN4 netrin 4 -0.0139741
NUCB1 nucleobindin 1 -0.0139655
SWAP70 SWAP switching B-cell complex 70kDa subunit -0.0139426
DCP1A decapping mRNA 1A -0.013895
FAM13B family with sequence similarity 13, member B -0.013883
NUP210 nucleoporin 210kDa -0.0138588
PAQR5 progestin and adipoQ receptor family member V -0.0138418
FAM168B family with sequence similarity 168, member B -0.0138365
LTBP1 latent transforming growth factor beta binding protein 1 -0.0138276
CAMTA1 calmodulin binding transcription activator 1 -0.0137837
ATE1 arginyltransferase 1 -0.013778
CKS2 CDC28 protein kinase regulatory subunit 2 -0.0137723
EML2 echinoderm microtubule associated protein like 2 -0.0137612
MUC13 mucin 13, cell surface associated -0.0137578
TFG TRK-fused gene -0.0137527
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 -0.0137489
DMAC2 distal membrane arm assembly component 2 -0.0137407
INTS10 integrator complex subunit 10 -0.0137388
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -0.0137368
BIN3 bridging integrator 3 -0.0137118
CTTN cortactin -0.0137115
ZFYVE9 zinc finger, FYVE domain containing 9 -0.0137051
COG4 component of oligomeric golgi complex 4 -0.0136973
APP amyloid beta (A4) precursor protein -0.0136942
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -0.0136155
ZFHX3 zinc finger homeobox 3 -0.0136109
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.01361
NR1D2 nuclear receptor subfamily 1, group D, member 2 -0.0136064
PRDX3 peroxiredoxin 3 -0.0136042
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa -0.0135692
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0135292
TSG101 tumor susceptibility 101 -0.0135161
AVPI1 arginine vasopressin-induced 1 -0.0135102
ZSCAN5A zinc finger and SCAN domain containing 5A -0.013503
CCSER2 coiled-coil serine-rich protein 2 -0.0134861
DCAKD dephospho-CoA kinase domain containing -0.0134738
SCARA5 scavenger receptor class A, member 5 -0.0133784
KEAP1 kelch-like ECH-associated protein 1 -0.0133751
PLXNA2 plexin A2 -0.0133578
ZNF346 zinc finger protein 346 -0.0133305
UBXN2A UBX domain protein 2A -0.0133264
TMEM135 transmembrane protein 135 -0.0133003
NUAK2 NUAK family, SNF1-like kinase, 2 -0.0132959
IGSF3 immunoglobulin superfamily, member 3 -0.0132812
USP54 ubiquitin specific peptidase 54 -0.0132365
UBALD1 UBA-like domain containing 1 -0.0131964
ZNF146 zinc finger protein 146 -0.0131738
SAFB2 scaffold attachment factor B2 -0.0131625
ATP13A3 ATPase type 13A3 -0.0131466
PFN1 profilin 1 -0.0130919
SLA2 Src-like-adaptor 2 -0.0130675
MTFMT mitochondrial methionyl-tRNA formyltransferase -0.0130544
TGFBR3 transforming growth factor, beta receptor III -0.0130464
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.013035
HIBCH 3-hydroxyisobutyryl-CoA hydrolase -0.0130266
CYFIP1 cytoplasmic FMR1 interacting protein 1 -0.0130236
REPS1 RALBP1 associated Eps domain containing 1 -0.0129975
RAD54L2 RAD54-like 2 (S. cerevisiae) -0.0129852
MLXIP MLX interacting protein -0.0129472
PROCR protein C receptor, endothelial -0.0129289
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast) -0.0129283
TOM1L2 target of myb1-like 2 (chicken) -0.0129228
FILIP1 filamin A interacting protein 1 -0.0129056
EFR3A EFR3 homolog A (S. cerevisiae) -0.0128991
RNF111 ring finger protein 111 -0.0128732
SINHCAF SIN3-HDAC complex associated factor -0.0128719
PTPN2 protein tyrosine phosphatase, non-receptor type 2 -0.0128607
RHOC ras homolog family member C -0.0128393
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0128387
SMAD5 SMAD family member 5 -0.0127774
SETDB1 SET domain, bifurcated 1 -0.012773
MIB1 mindbomb E3 ubiquitin protein ligase 1 -0.0127679
MAVS mitochondrial antiviral signaling protein -0.0127527
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0127429
PMM2 phosphomannomutase 2 -0.0127157
PHACTR2 phosphatase and actin regulator 2 -0.0127104
DENND5A DENN/MADD domain containing 5A -0.0127008
ABHD17C abhydrolase domain containing 17C -0.0126981
SNAP25 synaptosomal-associated protein, 25kDa -0.0126612
ZNF148 zinc finger protein 148 -0.012633
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0126261
ABHD3 abhydrolase domain containing 3 -0.0126016
THRB thyroid hormone receptor, beta -0.0125969
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0125853
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0125717
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A -0.0125706
CCDC146 coiled-coil domain containing 146 -0.0125578
GON4L gon-4-like (C. elegans) -0.0124727
TLE5 TLE family member 5, transcriptional modulator -0.0124587
SMG7 SMG7 nonsense mediated mRNA decay factor -0.0124521
LETMD1 LETM1 domain containing 1 -0.012443
SGCE sarcoglycan, epsilon -0.0124231
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -0.0124168
INTS6 integrator complex subunit 6 -0.0123835
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor -0.0123325