A549_Obatoclax Mesylate_100nM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description Obatoclax Mesylate 100nM perturbation in A549 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the A549_Obatoclax Mesylate_100nM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.164607
KRT8 keratin 8, type II 0.144068
KRT18 keratin 18, type I 0.128847
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0822262
RPLP1 ribosomal protein, large, P1 0.0821288
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0751623
MAP1B microtubule-associated protein 1B 0.0711464
FTL ferritin, light polypeptide 0.0700757
CENPF centromere protein F, 350/400kDa 0.0694228
AKR1C2 aldo-keto reductase family 1, member C2 0.0673022
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.0616547
PRRC2C proline-rich coiled-coil 2C 0.0595755
TKT transketolase 0.0574895
WWTR1 WW domain containing transcription regulator 1 0.0568999
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.053303
RNF213 ring finger protein 213 0.0530707
MKI67 marker of proliferation Ki-67 0.0527021
TUBA1B tubulin, alpha 1b 0.0496147
ZFHX3 zinc finger homeobox 3 0.0469435
POTEF POTE ankyrin domain family, member F 0.0454485
PLD5 phospholipase D family, member 5 0.0451307
RPL15 ribosomal protein L15 0.044619
PFN1 profilin 1 0.0442542
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0441689
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0415585
U2SURP U2 snRNP-associated SURP domain containing 0.0407347
MAP7 microtubule-associated protein 7 0.0396424
RPS6 ribosomal protein S6 0.0392021
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0387087
PDIA6 protein disulfide isomerase family A, member 6 0.0386366
RPS8 ribosomal protein S8 0.0381315
GCLC glutamate-cysteine ligase, catalytic subunit 0.037298
LARP4 La ribonucleoprotein domain family, member 4 0.0370197
ZFR zinc finger RNA binding protein 0.0369752
PTMS parathymosin 0.0369304
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0361455
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.036054
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.0359089
TOP2A topoisomerase (DNA) II alpha 170kDa 0.035831
MBNL1 muscleblind-like splicing regulator 1 0.0356978
NCAPD2 non-SMC condensin I complex, subunit D2 0.0353718
IGSF1 immunoglobulin superfamily, member 1 0.034436
CKAP4 cytoskeleton-associated protein 4 0.0343105
BCAP31 B-cell receptor-associated protein 31 0.0342657
GCLM glutamate-cysteine ligase, modifier subunit 0.0341277
PTPRM protein tyrosine phosphatase, receptor type, M 0.0340692
CCNT2 cyclin T2 0.0340619
CLEC16A C-type lectin domain family 16, member A 0.033787
LDHA lactate dehydrogenase A 0.033765
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0335985
SLC38A1 solute carrier family 38, member 1 0.0335965
PDZD8 PDZ domain containing 8 0.0330901
PCDH9 protocadherin 9 0.0329241
VGLL4 vestigial-like family member 4 0.0319372
SLC25A17 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 0.0318263
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0317042
TK1 thymidine kinase 1, soluble 0.0315538
LDHB lactate dehydrogenase B 0.0313405
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0308274
PHF14 PHD finger protein 14 0.030781
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.0305863
NFIA nuclear factor I/A 0.0305111
PEAK1 pseudopodium-enriched atypical kinase 1 0.0298503
GPC6 glypican 6 0.0297347
ANXA11 annexin A11 0.0296267
KIF5B kinesin family member 5B 0.0295517
FNDC3B fibronectin type III domain containing 3B 0.0294992
KRT7 keratin 7, type II 0.0293818
RNF217 ring finger protein 217 0.0293546
ALCAM activated leukocyte cell adhesion molecule 0.0292996
DSG2 desmoglein 2 0.0292988
RPN2 ribophorin II 0.0292695
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0290476
SCAF11 SR-related CTD-associated factor 11 0.0287175
VCP valosin containing protein 0.0286422
NUSAP1 nucleolar and spindle associated protein 1 0.0285457
SBF2 SET binding factor 2 0.0285124
CFDP1 craniofacial development protein 1 0.0283196
SRRM2 serine/arginine repetitive matrix 2 0.0282683
CD151 CD151 molecule (Raph blood group) 0.0282196
TSPAN15 tetraspanin 15 0.0278973
TPI1 triosephosphate isomerase 1 0.027876
INO80 INO80 complex subunit 0.027847
BRI3BP BRI3 binding protein 0.0278461
RAB10 RAB10, member RAS oncogene family 0.0278415
CTSD cathepsin D 0.0277727
UQCRC2 ubiquinol-cytochrome c reductase core protein II 0.0276569
PRICKLE2 prickle homolog 2 (Drosophila) 0.0276327
AKR1C3 aldo-keto reductase family 1, member C3 0.0275456
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0275311
RPLP2 ribosomal protein, large, P2 0.0275181
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0274642
TUBB tubulin, beta class I 0.0274012
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0273265
SH3D19 SH3 domain containing 19 0.0273248
ABHD12 abhydrolase domain containing 12 0.027234
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.0270404
DIDO1 death inducer-obliterator 1 0.026977
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.026965
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.0269237
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5 0.0269056
NOP56 NOP56 ribonucleoprotein 0.0268843
NAP1L4 nucleosome assembly protein 1-like 4 0.0268051
NUP214 nucleoporin 214kDa 0.0267526
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0267125
NACA nascent polypeptide-associated complex alpha subunit 0.0266651
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0264943
TRIR telomerase RNA component interacting RNase 0.0264852
SMG6 SMG6 nonsense mediated mRNA decay factor 0.0264735
RBBP8 retinoblastoma binding protein 8 0.0261021
DIAPH1 diaphanous-related formin 1 0.0259872
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) 0.0258874
NSRP1 nuclear speckle splicing regulatory protein 1 0.0257246
ACTN4 actinin, alpha 4 0.0256422
ZNF251 zinc finger protein 251 0.0256324
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0254435
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0254363
ZFAND5 zinc finger, AN1-type domain 5 0.025409
MESD mesoderm development LRP chaperone 0.0253977
GTF2IRD1 GTF2I repeat domain containing 1 0.0253968
BRCA1 breast cancer 1, early onset 0.0252737
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 0.0252539
ATAD2 ATPase family, AAA domain containing 2 0.0251181
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0251096
NFIB nuclear factor I/B 0.0250492
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 0.0250209
SFMBT2 Scm-like with four mbt domains 2 0.0249959
FTH1 ferritin, heavy polypeptide 1 0.0249431
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.024855
BASP1 brain abundant, membrane attached signal protein 1 0.0247305
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.0244175
TRIM28 tripartite motif containing 28 0.0242923
GOPC golgi-associated PDZ and coiled-coil motif containing 0.0242355
UBL4A ubiquitin-like 4A 0.0240881
SHARPIN SHANK-associated RH domain interactor 0.0239624
CCND1 cyclin D1 0.0239593
UBE2S ubiquitin-conjugating enzyme E2S 0.0238887
MOSMO modulator of smoothened 0.0238819
LOC112694756 uncharaterized LOC112694756 0.0237291
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0237239
EHBP1 EH domain binding protein 1 0.0235921
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0234935
CREBBP CREB binding protein 0.0234332
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0232452
CTNND1 catenin (cadherin-associated protein), delta 1 0.0232218
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0231307
PBX3 pre-B-cell leukemia homeobox 3 0.0231217
RRP1B ribosomal RNA processing 1B 0.0231021
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0230728
MZT2B mitotic spindle organizing protein 2B 0.0230611
PRMT3 protein arginine methyltransferase 3 0.0229493
LMBR1 limb development membrane protein 1 0.0228605
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 0.0228331
VIM vimentin 0.0227385
MICU1 mitochondrial calcium uptake 1 0.0225519
LLGL2 lethal giant larvae homolog 2 (Drosophila) 0.0225479
KRIT1 KRIT1, ankyrin repeat containing 0.0225082
CANX calnexin 0.0223485
CYBA cytochrome b-245, alpha polypeptide 0.0222273
PLEKHA6 pleckstrin homology domain containing, family A member 6 0.0221991
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0220847
BMPR1B bone morphogenetic protein receptor, type IB 0.0220616
FAM169A family with sequence similarity 169, member A 0.0220001
ITGA6 integrin, alpha 6 0.0219679
IGF1R insulin-like growth factor 1 receptor 0.021869
RPL13A ribosomal protein L13a 0.0218536
PCYOX1 prenylcysteine oxidase 1 0.0217616
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 0.0217062
KDM6A lysine (K)-specific demethylase 6A 0.0216835
KAT6B K(lysine) acetyltransferase 6B 0.0216599
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0216254
NUP155 nucleoporin 155kDa 0.0215992
MRPS34 mitochondrial ribosomal protein S34 0.0215349
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0215011
KIAA0232 KIAA0232 0.0214964
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0213879
UVRAG UV radiation resistance associated 0.0213388
ZNF609 zinc finger protein 609 0.0212013
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0211945
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0211877
RPL5 ribosomal protein L5 0.0211614
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0211456
RNF111 ring finger protein 111 0.021142
AGO3 argonaute RISC catalytic component 3 0.0211366
SKAP2 src kinase associated phosphoprotein 2 0.0210784
CHMP2A charged multivesicular body protein 2A 0.021078
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0210505
KPNB1 karyopherin (importin) beta 1 0.0210171
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.0209366
EPB41L4A erythrocyte membrane protein band 4.1 like 4A 0.0208952
ADGRG6 adhesion G protein-coupled receptor G6 0.0207848
NRDC nardilysin convertase 0.0207084
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0206213
PPP1R13B protein phosphatase 1, regulatory subunit 13B 0.0206132
RABGAP1L RAB GTPase activating protein 1-like 0.020579
PDCD11 programmed cell death 11 0.020576
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.0205091
PGPEP1 pyroglutamyl-peptidase I 0.0204907
TMPO thymopoietin 0.0204736
MORC4 MORC family CW-type zinc finger 4 0.0204639
ZNF217 zinc finger protein 217 0.0204129
RPL27 ribosomal protein L27 0.0204035
TCF25 transcription factor 25 (basic helix-loop-helix) 0.0203579
DUSP16 dual specificity phosphatase 16 0.0203413
H3-3B H3.3 histone B 0.0203235
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0202667
CDK13 cyclin-dependent kinase 13 0.0202536
KNTC1 kinetochore associated 1 0.0202214
ARPP19 cAMP-regulated phosphoprotein, 19kDa 0.0201936
USP24 ubiquitin specific peptidase 24 0.0201864
DMWD dystrophia myotonica, WD repeat containing 0.020127
HSPA4 heat shock 70kDa protein 4 0.0200268
HOMER2 homer scaffolding protein 2 0.0200019
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0198509
UBASH3B ubiquitin associated and SH3 domain containing B 0.019802
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.0197331
SELENOI selenoprotein I 0.0197237
SLC75A1 solute carrier family 75 member 1 0.0197051
ZYG11B zyg-11 family member B, cell cycle regulator 0.0196784
MGME1 mitochondrial genome maintenance exonuclease 1 0.0195987
DIPK1A divergent protein kinase domain 1A 0.0195645
DCDC2 doublecortin domain containing 2 0.0194819
KLHL23 kelch-like family member 23 0.0194458
NUP160 nucleoporin 160kDa 0.0194445
EMP2 epithelial membrane protein 2 0.0194382
TSC22D1 TSC22 domain family, member 1 0.0193836
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) 0.019299
CEMIP2 cell migration inducing hyaluronidase 2 0.0192269
SEPTIN11 septin 11 0.0192148
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0192079
NBR1 neighbor of BRCA1 gene 1 0.0190652
STIM1 stromal interaction molecule 1 0.0190446
FANCC Fanconi anemia, complementation group C 0.0190371
LCOR ligand dependent nuclear receptor corepressor 0.018876
FAM20B family with sequence similarity 20, member B 0.0188657
TXNRD1 thioredoxin reductase 1 0.0188184
TALDO1 transaldolase 1 0.0187891
DOP1B DOP1 leucine zipper like protein B 0.0187671
NAMPT nicotinamide phosphoribosyltransferase 0.018747
SNX9 sorting nexin 9 0.0186032
CSNK1G3 casein kinase 1, gamma 3 0.0185325
HSPH1 heat shock 105kDa/110kDa protein 1 0.0185114
SHOC2 soc-2 suppressor of clear homolog (C. elegans) 0.0184948
TOP1 topoisomerase (DNA) I 0.0184196
PCBP2 poly(rC) binding protein 2 0.0184033
THOC2 THO complex 2 0.0183751
MLEC malectin 0.0183401
RPL4 ribosomal protein L4 0.0183261
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 0.0183234
NCOR1 nuclear receptor corepressor 1 0.0183048
SIK3 SIK family kinase 3 0.0182783
STAU2 staufen double-stranded RNA binding protein 2 0.0182283
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 0.0182179
NTS neurotensin 0.0181874
PANK2 pantothenate kinase 2 0.0181383
METTL2A methyltransferase like 2A 0.0181351
MTREX Mtr4 exosome RNA helicase 0.0181255
FKBP5 FK506 binding protein 5 0.0181207
ANLN anillin, actin binding protein 0.0180941
RDH10 retinol dehydrogenase 10 (all-trans) 0.0180703
CHD4 chromodomain helicase DNA binding protein 4 0.0180498
NT5C3A 5'-nucleotidase, cytosolic IIIA 0.0180392
TTC17 tetratricopeptide repeat domain 17 0.018027
LY6E lymphocyte antigen 6 complex, locus E 0.0179523
S100A4 S100 calcium binding protein A4 0.0179232
ATAD1 ATPase family, AAA domain containing 1 0.0179026
RBM10 RNA binding motif protein 10 0.017884
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 0.0178219
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0177925
ELOB elongin B 0.0177813
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0177608
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 0.0177282
EXOC4 exocyst complex component 4 0.0177188
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0176876
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 0.0176875
LYN LYN proto-oncogene, Src family tyrosine kinase 0.0176746
TMSB10 thymosin beta 10 0.0176667
CCT3 chaperonin containing TCP1, subunit 3 (gamma) 0.0176431
GOLGB1 golgin B1 0.0176249
CD81 CD81 molecule 0.0176185
SSR1 signal sequence receptor, alpha 0.0175425
DCLK2 doublecortin-like kinase 2 0.0175008
HMG20A high mobility group 20A 0.0174885
ACACA acetyl-CoA carboxylase alpha 0.0174795
KLHL5 kelch-like family member 5 0.0174637
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast) 0.0174499
SAMD1 sterile alpha motif domain containing 1 0.017443
UGP2 UDP-glucose pyrophosphorylase 2 0.0174246
GOLPH3L golgi phosphoprotein 3-like 0.0173746
TOMM6 translocase of outer mitochondrial membrane 6 homolog (yeast) 0.0173625
ECE1 endothelin converting enzyme 1 0.0173026
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0172801
CACYBP calcyclin binding protein 0.0172528
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 0.0172223
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 0.0171951
TRIM44 tripartite motif containing 44 0.0171949
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 0.0171329
TRA2A transformer 2 alpha homolog (Drosophila) 0.0170736
RFLNB refilin B 0.0170187
NUP88 nucleoporin 88kDa 0.0169859
STOM stomatin 0.0169822
PRMT9 protein arginine methyltransferase 9 0.0169518
FRS2 fibroblast growth factor receptor substrate 2 0.0169374
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 0.0168741
GMCL1 germ cell-less, spermatogenesis associated 1 0.0168565
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein 0.0168536
GKAP1 G kinase anchoring protein 1 0.0168454
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0168327
MYO1E myosin IE 0.0167301
PCGF6 polycomb group ring finger 6 0.0167263
ZDHHC20 zinc finger, DHHC-type containing 20 0.0167224
ZDHHC13 zinc finger, DHHC-type containing 13 0.0166977
RNF13 ring finger protein 13 0.0166933
KNOP1 lysine-rich nucleolar protein 1 0.0166923
RPL18 ribosomal protein L18 0.0166777
KANSL1L KAT8 regulatory NSL complex subunit 1-like 0.0166704
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0166579
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.0166316
FUCA2 fucosidase, alpha-L- 2, plasma 0.016584
CLIC1 chloride intracellular channel 1 0.0165636
TCERG1 transcription elongation regulator 1 0.0165277
PBX1 pre-B-cell leukemia homeobox 1 0.0165251
RPL38 ribosomal protein L38 0.0164373
AHCYL1 adenosylhomocysteinase-like 1 0.0163647
MAGT1 magnesium transporter 1 0.0163114
FBXO46 F-box protein 46 0.0163038
PDCD6IP programmed cell death 6 interacting protein 0.0162985
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 0.0162886
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0162806
SNX1 sorting nexin 1 0.0162287
HDAC4 histone deacetylase 4 0.0162128
AQR aquarius intron-binding spliceosomal factor 0.0161803
FBXO34 F-box protein 34 0.0161411
SACS sacsin molecular chaperone 0.0161195
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0160976
SH3PXD2A SH3 and PX domains 2A 0.0160818
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.016073
JOSD1 Josephin domain containing 1 0.0160657
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0160564
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0160502
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.0160317
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) 0.016031
WDR20 WD repeat domain 20 0.0159691
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 0.0159643
TMEM165 transmembrane protein 165 0.0159018
PTGES2 prostaglandin E synthase 2 0.0158921
TMTC3 transmembrane and tetratricopeptide repeat containing 3 0.0158811
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 0.0158788
MGST2 microsomal glutathione S-transferase 2 0.015854
TRIM16 tripartite motif containing 16 0.0158499
HAT1 histone acetyltransferase 1 0.0158444
SSRP1 structure specific recognition protein 1 0.0158412
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 0.0158212
RBL1 retinoblastoma-like 1 0.0157981
USP49 ubiquitin specific peptidase 49 0.0157738
DDI2 DNA-damage inducible 1 homolog 2 (S. cerevisiae) 0.0157575
METRN meteorin, glial cell differentiation regulator 0.0157574
SSBP3 single stranded DNA binding protein 3 0.0157293
EPN2 epsin 2 0.0157139
C1ORF122 chromosome 1 open reading frame 122 0.0157108
REEP5 receptor accessory protein 5 0.0156921
FBXO17 F-box protein 17 0.0156601
ANKRD44 ankyrin repeat domain 44 0.0156576
GRN granulin 0.0156403
TAF6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa 0.0156057
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0154944
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa 0.0154888
TTC19 tetratricopeptide repeat domain 19 0.0154537
IER5L immediate early response 5-like 0.0154464
EMSY EMSY transcriptional repressor, BRCA2 interacting 0.0154288
MCM6 minichromosome maintenance complex component 6 0.0154121
NTPCR nucleoside-triphosphatase, cancer-related 0.0153472
ZNF438 zinc finger protein 438 0.0153445
LTBP1 latent transforming growth factor beta binding protein 1 0.0153368
INO80D INO80 complex subunit D 0.0153131
SF1 splicing factor 1 0.0153047
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0153005
USP22 ubiquitin specific peptidase 22 0.0152734
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 0.0152418
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 0.0152244
VEZT vezatin, adherens junctions transmembrane protein 0.0152204
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 0.0152045
TMCO1 transmembrane and coiled-coil domains 1 0.015186
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 0.0151578
FUS FUS RNA binding protein 0.0151411
POLK polymerase (DNA directed) kappa 0.0151406
CASC3 cancer susceptibility candidate 3 0.0151359
RNPS1 RNA binding protein S1, serine-rich domain 0.015123
RPL12 ribosomal protein L12 0.0151132
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.015112
RPL30 ribosomal protein L30 0.0150689
TMEM127 transmembrane protein 127 0.0150657
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae) 0.0150386
NHSL1 NHS-like 1 0.0150176
PCDHB16 protocadherin beta 16 0.0149871
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 0.0149607
TPM2 tropomyosin 2 (beta) 0.0149244
BCL2L1 BCL2-like 1 0.0148938
XBP1 X-box binding protein 1 0.0148928
EIF3B eukaryotic translation initiation factor 3, subunit B 0.0147994
VRK3 vaccinia related kinase 3 0.01479
UCK2 uridine-cytidine kinase 2 0.0147766
PLS1 plastin 1 0.0147538
TBC1D4 TBC1 domain family, member 4 0.0147403
POLR1G RNA polymerase I subunit G 0.0147312
NAPEPLD N-acyl phosphatidylethanolamine phospholipase D 0.0147283
CCDC34 coiled-coil domain containing 34 0.0147172
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0146898
FRMD5 FERM domain containing 5 0.0146612
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 0.0145803
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 0.014529
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0145284
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 0.0145084
MMS22L MMS22-like, DNA repair protein 0.014485
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0144849
UEVLD UEV and lactate/malate dehyrogenase domains 0.0144565
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.0144501
TCP11L1 t-complex 11, testis-specific-like 1 0.0144474
DNAH14 dynein, axonemal, heavy chain 14 0.0144323
CTPS2 CTP synthase 2 0.0144102
DIAPH3 diaphanous-related formin 3 0.0144073
FAM120C family with sequence similarity 120C 0.0143865
SERBP1 SERPINE1 mRNA binding protein 1 0.0143741
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0143449
SLC4A2 solute carrier family 4 (anion exchanger), member 2 0.0143396
C18ORF25 chromosome 18 open reading frame 25 0.0143278
SEC23A Sec23 homolog A (S. cerevisiae) 0.0143227
VAMP8 vesicle-associated membrane protein 8 0.0143206
WASHC4 WASH complex subunit 4 0.0143095
RPS23 ribosomal protein S23 0.0143047
NLN neurolysin (metallopeptidase M3 family) 0.014293
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) 0.0142741
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 0.0142684
MBD5 methyl-CpG binding domain protein 5 0.0142553
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0142502
TMX1 thioredoxin-related transmembrane protein 1 0.0141976
PSPC1 paraspeckle component 1 0.0141799
S100A10 S100 calcium binding protein A10 0.0141651
CCNT1 cyclin T1 0.0141612
RHOBTB1 Rho-related BTB domain containing 1 0.0141168
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0140705
CDR2 cerebellar degeneration-related protein 2, 62kDa 0.0140314
EXOC5 exocyst complex component 5 0.0139956
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 0.0139919
TOR1AIP2 torsin A interacting protein 2 0.0139867
CLASP1 cytoplasmic linker associated protein 1 0.0139814
PRR11 proline rich 11 0.0139296
IL18 interleukin 18 0.0138977
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0138945
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0138908
ERBIN erbb2 interacting protein 0.0138839
APAF1 apoptotic peptidase activating factor 1 0.013882
SNF8 SNF8, ESCRT-II complex subunit 0.0138788
INTS2 integrator complex subunit 2 0.0138677
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0138637
BCAR3 breast cancer anti-estrogen resistance 3 0.0138615
HEATR1 HEAT repeat containing 1 0.0138321
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) 0.0138057
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.013798
DGAT1 diacylglycerol O-acyltransferase 1 0.0137886
CENPB centromere protein B, 80kDa 0.0137851
CTSC cathepsin C 0.0137617
TFPI2 tissue factor pathway inhibitor 2 0.0137569
ACTG1 actin gamma 1 0.0137381
BIRC3 baculoviral IAP repeat containing 3 0.0137087
SEPTIN6 septin 6 0.013616
GPS2 G protein pathway suppressor 2 0.013594
RASAL2 RAS protein activator like 2 0.0135683
TBXAS1 thromboxane A synthase 1 (platelet) 0.0135653
TLN1 talin 1 0.0135572
EEF2K eukaryotic elongation factor 2 kinase 0.0135423
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0135333
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 0.0135313
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.013531
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 0.0135206
APLP2 amyloid beta (A4) precursor-like protein 2 0.0134956
DGKE diacylglycerol kinase, epsilon 64kDa 0.0134685
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0134617
EVI5 ecotropic viral integration site 5 0.0134405
TUBB4B tubulin, beta 4B class IVb 0.01342
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0134131
PDIA3 protein disulfide isomerase family A, member 3 0.0134007
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0133976
CANT1 calcium activated nucleotidase 1 0.0133967
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa 0.0133892
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 0.0133795
NSD1 nuclear receptor binding SET domain protein 1 0.0133778
INTS9 integrator complex subunit 9 0.0133744
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 0.0133639
FANCI Fanconi anemia, complementation group I 0.0133486
PAWR PRKC, apoptosis, WT1, regulator 0.013325
IL1R1 interleukin 1 receptor, type I 0.0133223
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 0.0133088
PUM1 pumilio RNA-binding family member 1 0.0132865
BCOR BCL6 corepressor 0.0132842
EIF5B eukaryotic translation initiation factor 5B 0.0132677
ATP13A1 ATPase type 13A1 0.0132476
GPR135 G protein-coupled receptor 135 0.0132474
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 0.0131956
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0131775

decreased expression

Symbol Name Standardized Value
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.142398
PTGR1 prostaglandin reductase 1 -0.127171
CUX1 cut-like homeobox 1 -0.0802435
ZBTB20 zinc finger and BTB domain containing 20 -0.0691407
WWOX WW domain containing oxidoreductase -0.0606098
HIP1 huntingtin interacting protein 1 -0.0592328
NRG1 neuregulin 1 -0.0575038
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0575024
RAD51B RAD51 paralog B -0.0554987
PHGDH phosphoglycerate dehydrogenase -0.0544628
CMIP c-Maf inducing protein -0.053953
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0528542
NBEA neurobeachin -0.0513438
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -0.051152
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.0488603
AUTS2 autism susceptibility candidate 2 -0.0488479
IGFBP4 insulin-like growth factor binding protein 4 -0.0484562
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0479477
RPS2 ribosomal protein S2 -0.0472573
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase -0.047192
BCAS3 breast carcinoma amplified sequence 3 -0.0471899
PTPRK protein tyrosine phosphatase, receptor type, K -0.0465947
LIMCH1 LIM and calponin homology domains 1 -0.0461005
FAF1 Fas (TNFRSF6) associated factor 1 -0.0459101
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0450969
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0450258
DOCK5 dedicator of cytokinesis 5 -0.0447189
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.044063
CNTNAP3B contactin associated protein-like 3B -0.043667
PATJ PATJ crumbs cell polarity complex component -0.0434403
LMNA lamin A/C -0.043037
MYADM myeloid-associated differentiation marker -0.042293
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0422681
RPS11 ribosomal protein S11 -0.0422403
PLEC plectin -0.0422263
PTK2 protein tyrosine kinase 2 -0.041922
PDE4B phosphodiesterase 4B, cAMP-specific -0.0418732
PDE8A phosphodiesterase 8A -0.041079
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) -0.0409053
LRMDA leucine rich melanocyte differentiation associated -0.0402468
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0402294
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0399859
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 -0.0395558
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0394304
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0387077
THSD4 thrombospondin, type I, domain containing 4 -0.0385878
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0384938
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.0381385
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0378207
TNRC6B trinucleotide repeat containing 6B -0.0378204
ITGB5 integrin, beta 5 -0.0369388
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0368674
FAM222B family with sequence similarity 222, member B -0.0367058
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0356185
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0351688
GMDS GDP-mannose 4,6-dehydratase -0.0350373
TTC28 tetratricopeptide repeat domain 28 -0.0347122
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0347064
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) -0.0346955
CP ceruloplasmin (ferroxidase) -0.0346559
LAMB1 laminin, beta 1 -0.0343191
C5 complement component 5 -0.0341996
FCGBP Fc fragment of IgG binding protein -0.0341916
SQSTM1 sequestosome 1 -0.0341538
GPATCH8 G patch domain containing 8 -0.0338815
FLNA filamin A, alpha -0.033612
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 -0.033224
EVA1C eva-1 homolog C (C. elegans) -0.033006
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.032917
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0328435
CHD9 chromodomain helicase DNA binding protein 9 -0.0328429
TACC1 transforming, acidic coiled-coil containing protein 1 -0.0328241
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 -0.0327615
RBM39 RNA binding motif protein 39 -0.0326238
QRICH1 glutamine-rich 1 -0.0325835
FBXO11 F-box protein 11 -0.0325831
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0325204
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -0.0320091
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0318669
TBL1X transducin (beta)-like 1X-linked -0.031841
SERINC5 serine incorporator 5 -0.0318046
BICC1 BicC family RNA binding protein 1 -0.0317868
ATXN1 ataxin 1 -0.0317482
KYNU kynureninase -0.0317289
FAM168A family with sequence similarity 168, member A -0.0316579
DENND4A DENN/MADD domain containing 4A -0.0315251
ANKRD11 ankyrin repeat domain 11 -0.0311929
DENND5B DENN/MADD domain containing 5B -0.0305919
CLIP2 CAP-GLY domain containing linker protein 2 -0.0305041
FOXK2 forkhead box K2 -0.0304723
CERS6 ceramide synthase 6 -0.0304503
PON2 paraoxonase 2 -0.0302194
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0301932
PARD3 par-3 family cell polarity regulator -0.0300707
TMEM245 transmembrane protein 245 -0.0297791
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0296092
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0295168
LPP LIM domain containing preferred translocation partner in lipoma -0.029486
ATXN2 ataxin 2 -0.0294381
PHC3 polyhomeotic homolog 3 (Drosophila) -0.0293661
PHACTR4 phosphatase and actin regulator 4 -0.0292184
RFX7 regulatory factor X, 7 -0.0292034
COP1 COP1 E3 ubiquitin ligase -0.029079
PLPP1 phospholipid phosphatase 1 -0.0289926
MSI2 musashi RNA-binding protein 2 -0.0287132
NPAS2 neuronal PAS domain protein 2 -0.0286826
AKR1C1 aldo-keto reductase family 1, member C1 -0.0285926
TRIO trio Rho guanine nucleotide exchange factor -0.0283199
ETV6 ets variant 6 -0.0283038
FYCO1 FYVE and coiled-coil domain containing 1 -0.0279681
MAP4 microtubule-associated protein 4 -0.0279531
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma -0.0278413
EDF1 endothelial differentiation-related factor 1 -0.0278192
SLC22A23 solute carrier family 22, member 23 -0.0277857
WDR70 WD repeat domain 70 -0.0277808
VCAN versican -0.027691
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -0.0276762
EIF4B eukaryotic translation initiation factor 4B -0.027443
UBAP2 ubiquitin associated protein 2 -0.0274286
KIF13A kinesin family member 13A -0.0273577
CDC27 cell division cycle 27 -0.0273432
KIAA1958 KIAA1958 -0.0271833
RBMX RNA binding motif protein, X-linked -0.0271502
MVP major vault protein -0.0270478
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -0.0269422
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) -0.0269175
IRS2 insulin receptor substrate 2 -0.0266429
PARN poly(A)-specific ribonuclease -0.0266205
TM4SF1 transmembrane 4 L six family member 1 -0.0264978
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0264947
MYO1D myosin ID -0.0263279
WRN Werner syndrome, RecQ helicase-like -0.026132
GON4L gon-4-like (C. elegans) -0.0260169
MUSK muscle, skeletal, receptor tyrosine kinase -0.0259914
ATG7 autophagy related 7 -0.02599
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.0259642
THRB thyroid hormone receptor, beta -0.0259476
PRPF8 pre-mRNA processing factor 8 -0.0258573
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0257582
KIAA0319L KIAA0319-like -0.0254952
VCL vinculin -0.025479
NF1 neurofibromin 1 -0.0254089
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0254083
MED13 mediator complex subunit 13 -0.0254022
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0253825
MAGED1 melanoma antigen family D1 -0.0253653
PRKD2 protein kinase D2 -0.02522
FBXL20 F-box and leucine-rich repeat protein 20 -0.0251866
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.02503
CYFIP1 cytoplasmic FMR1 interacting protein 1 -0.0249752
EML4 echinoderm microtubule associated protein like 4 -0.0249445
CDK17 cyclin-dependent kinase 17 -0.0248602
AXL AXL receptor tyrosine kinase -0.0247747
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0247301
DGKH diacylglycerol kinase, eta -0.0246386
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 -0.024519
ZNF146 zinc finger protein 146 -0.0244994
MAP3K7 mitogen-activated protein kinase kinase kinase 7 -0.0244576
ZBTB35 zinc finger and BTB domain containing 35 -0.0244487
YBX3 Y box binding protein 3 -0.0244237
ANXA7 annexin A7 -0.0242994
DICER1 dicer 1, ribonuclease type III -0.0241758
CEP290 centrosomal protein 290kDa -0.0241542
GOLM1 golgi membrane protein 1 -0.0241286
PDLIM5 PDZ and LIM domain 5 -0.0240747
TPCN1 two pore segment channel 1 -0.023887
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0238855
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 -0.0238656
CUL4A cullin 4A -0.0238641
SP3 Sp3 transcription factor -0.0237788
COPB1 coatomer protein complex, subunit beta 1 -0.0237395
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0237289
PAPOLA poly(A) polymerase alpha -0.0237089
SREBF1 sterol regulatory element binding transcription factor 1 -0.0236615
NSD3 nuclear receptor binding SET domain protein 3 -0.0234585
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0234551
DOCK4 dedicator of cytokinesis 4 -0.0234338
ZFAND3 zinc finger, AN1-type domain 3 -0.0233885
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0233271
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0233031
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0232652
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0231435
GDI2 GDP dissociation inhibitor 2 -0.0230725
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0230321
MORF4L1 mortality factor 4 like 1 -0.0229576
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0229516
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0229374
SNX25 sorting nexin 25 -0.0229046
ARF4 ADP-ribosylation factor 4 -0.0228582
SLTM SAFB-like, transcription modulator -0.0228241
STRN striatin, calmodulin binding protein -0.0226931
DPY19L1 dpy-19-like 1 (C. elegans) -0.0226929
TENT2 terminal nucleotidyltransferase 2 -0.022682
CHD1 chromodomain helicase DNA binding protein 1 -0.0226358
TLN2 talin 2 -0.0226192
PKP4 plakophilin 4 -0.0226124
LAMA5 laminin, alpha 5 -0.0225657
AGO2 argonaute RISC catalytic component 2 -0.0225465
DIAPH2 diaphanous-related formin 2 -0.0225238
ADCY8 adenylate cyclase 8 (brain) -0.0225114
USP36 ubiquitin specific peptidase 36 -0.0223208
FRMD3 FERM domain containing 3 -0.0222621
ARHGAP12 Rho GTPase activating protein 12 -0.0222417
BICD1 bicaudal D homolog 1 (Drosophila) -0.0221914
EHMT1 euchromatic histone-lysine N-methyltransferase 1 -0.0221705
MYOF myoferlin -0.0221594
TRMT61B tRNA methyltransferase 61B -0.0221529
AATF apoptosis antagonizing transcription factor -0.0220939
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0220412
S100A6 S100 calcium binding protein A6 -0.0220093
ILF3 interleukin enhancer binding factor 3, 90kDa -0.0219917
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor -0.0219839
DNAAF9 dynein axonemal assembly factor 9 -0.0219819
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0219661
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0219595
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0219528
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0219321
PICALM phosphatidylinositol binding clathrin assembly protein -0.021893
JUP junction plakoglobin -0.0218683
TTC7A tetratricopeptide repeat domain 7A -0.0218258
PALLD palladin, cytoskeletal associated protein -0.0218213
NIPSNAP2 nipsnap homolog 2 -0.0218188
NUMB numb homolog (Drosophila) -0.0218063
DAPK1 death-associated protein kinase 1 -0.0218015
PDE10A phosphodiesterase 10A -0.0217411
SPATS2 spermatogenesis associated, serine-rich 2 -0.0217395
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta -0.0217358
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 -0.0217233
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 -0.0217011
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0216884
CNKSR3 CNKSR family member 3 -0.0216653
ATE1 arginyltransferase 1 -0.0216179
HDAC8 histone deacetylase 8 -0.0216104
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0215497
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0215195
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 -0.0215183
ACAD10 acyl-CoA dehydrogenase family, member 10 -0.0214901
MACF1 microtubule-actin crosslinking factor 1 -0.0213676
STXBP5 syntaxin binding protein 5 (tomosyn) -0.021297
WDFY3 WD repeat and FYVE domain containing 3 -0.0212787
GNG12 guanine nucleotide binding protein (G protein), gamma 12 -0.0212675
ATF7IP activating transcription factor 7 interacting protein -0.021208
SVIL supervillin -0.0212039
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0211373
CARM1 coactivator-associated arginine methyltransferase 1 -0.0211119
GPRIN3 GPRIN family member 3 -0.0211072
LASP1 LIM and SH3 protein 1 -0.0210749
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 -0.0210369
AOPEP aminopeptidase O (putative) -0.0210197
STIL SCL/TAL1 interrupting locus -0.020957
MYO18A myosin XVIIIA -0.0209501
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0209173
ELL2 elongation factor, RNA polymerase II, 2 -0.0209093
KLF3 Kruppel-like factor 3 (basic) -0.0208838
DENND4C DENN/MADD domain containing 4C -0.0208626
FAM107B family with sequence similarity 107, member B -0.0207679
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.020729
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0206379
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0206136
GALM galactose mutarotase (aldose 1-epimerase) -0.0205799
FOXK1 forkhead box K1 -0.0205772
GLDC glycine dehydrogenase (decarboxylating) -0.0205157
MON2 MON2 homolog (S. cerevisiae) -0.0204795
DARS1 aspartyl-tRNA synthetase 1 -0.0204523
BIRC6 baculoviral IAP repeat containing 6 -0.0204422
CLPTM1 cleft lip and palate associated transmembrane protein 1 -0.0204146
LRRK1 leucine-rich repeat kinase 1 -0.0203983
GLG1 golgi glycoprotein 1 -0.0203454
NKTR natural killer cell triggering receptor -0.0203176
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0202963
CA12 carbonic anhydrase XII -0.0202856
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha -0.020264
ITCH itchy E3 ubiquitin protein ligase -0.0202517
LRRC28 leucine rich repeat containing 28 -0.020208
SPG11 spastic paraplegia 11 (autosomal recessive) -0.0201943
PHB1 prohibitin 1 -0.0201724
TLK2 tousled-like kinase 2 -0.020161
GSK3B glycogen synthase kinase 3 beta -0.0201524
MLPH melanophilin -0.0201514
USP9X ubiquitin specific peptidase 9, X-linked -0.0201264
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 -0.0201033
ATP9B ATPase, class II, type 9B -0.0201023
GLE1 GLE1 RNA export mediator -0.0200741
NMT1 N-myristoyltransferase 1 -0.0200219
SON SON DNA binding protein -0.0199707
PLCB4 phospholipase C, beta 4 -0.0199519
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0199462
CD38 CD38 molecule -0.0199448
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 -0.0199362
SSR2 signal sequence receptor, beta (translocon-associated protein beta) -0.0198914
RPLP0 ribosomal protein, large, P0 -0.019884
PTAR1 protein prenyltransferase alpha subunit repeat containing 1 -0.0198563
SUZ12 SUZ12 polycomb repressive complex 2 subunit -0.0198028
KIF13B kinesin family member 13B -0.0197332
RBM5 RNA binding motif protein 5 -0.0197205
ANAPC16 anaphase promoting complex subunit 16 -0.019717
PFKP phosphofructokinase, platelet -0.0196993
ARMH3 armadillo like helical domain containing 3 -0.0195393
FILIP1 filamin A interacting protein 1 -0.0195329
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B -0.0194203
GPR39 G protein-coupled receptor 39 -0.0193742
PLD3 phospholipase D family, member 3 -0.0193524
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0193488
OLA1 Obg-like ATPase 1 -0.0192774
COG5 component of oligomeric golgi complex 5 -0.0192558
TFG TRK-fused gene -0.0192332
FOXP1 forkhead box P1 -0.019187
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 -0.0190914
EFNA5 ephrin-A5 -0.0190674
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0190225
LIMD1 LIM domains containing 1 -0.0190156
DSTN destrin (actin depolymerizing factor) -0.0190144
FAM177A1 family with sequence similarity 177, member A1 -0.0190079
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.0189939
BOD1L1 biorientation of chromosomes in cell division 1-like 1 -0.01898
DTNB dystrobrevin, beta -0.0189616
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0188963
GCC2 GRIP and coiled-coil domain containing 2 -0.0188385
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 -0.0188354
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0188353
ARHGAP29 Rho GTPase activating protein 29 -0.0188297
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -0.0188008
RNF38 ring finger protein 38 -0.0187954
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.018784
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0187751
CORO1C coronin, actin binding protein, 1C -0.0187741
CCDC57 coiled-coil domain containing 57 -0.0187708
TRAPPC8 trafficking protein particle complex 8 -0.0187706
WIPF1 WAS/WASL interacting protein family, member 1 -0.0187313
PIKFYVE phosphoinositide kinase, FYVE finger containing -0.0186899
NPTN neuroplastin -0.0186065
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0185774
POU2F1 POU class 2 homeobox 1 -0.0185718
CD2AP CD2-associated protein -0.0184623
CKAP5 cytoskeleton associated protein 5 -0.0184598
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.0184378
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.018418
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.0183656
DERL2 derlin 2 -0.0183496
PROCR protein C receptor, endothelial -0.0182877
KHDC4 KH domain containing 4, pre-mRNA splicing factor -0.0182741
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 -0.0182583
ZNF124 zinc finger protein 124 -0.018256
EEIG1 estrogen-induced osteoclastogenesis regulator 1 -0.0182229
FNDC3A fibronectin type III domain containing 3A -0.0182099
FOXN3 forkhead box N3 -0.0181729
SMC6 structural maintenance of chromosomes 6 -0.0181672
PDXK pyridoxal (pyridoxine, vitamin B6) kinase -0.0181426
ARHGAP35 Rho GTPase activating protein 35 -0.0181301
SLC45A4 solute carrier family 45, member 4 -0.018107
MACROD2 MACRO domain containing 2 -0.0180894
MAN1B1 mannosidase, alpha, class 1B, member 1 -0.0180697
R3HDM1 R3H domain containing 1 -0.0180076
TMEM135 transmembrane protein 135 -0.0179921
IQGAP2 IQ motif containing GTPase activating protein 2 -0.0179737
CDK6 cyclin-dependent kinase 6 -0.0179339
MLH3 mutL homolog 3 -0.0179295
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) -0.0178736
TAOK1 TAO kinase 1 -0.0178724
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) -0.0178702
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0178617
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0178341
SART1 squamous cell carcinoma antigen recognized by T cells -0.0177598
ANAPC5 anaphase promoting complex subunit 5 -0.0175753
RUVBL2 RuvB-like AAA ATPase 2 -0.0175047
UNK unkempt family zinc finger -0.0174919
OPHN1 oligophrenin 1 -0.0174287
DST dystonin -0.0174072
RRAS2 related RAS viral (r-ras) oncogene homolog 2 -0.0173885
FIGN fidgetin -0.0173141
SMG7 SMG7 nonsense mediated mRNA decay factor -0.0173087
DMXL1 Dmx-like 1 -0.0172706
RECQL RecQ helicase-like -0.0172678
AKAP9 A kinase (PRKA) anchor protein 9 -0.0172245
FBXL17 F-box and leucine-rich repeat protein 17 -0.0171509
APTX aprataxin -0.017146
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0171458
RRBP1 ribosome binding protein 1 -0.0171272
EZR ezrin -0.0170935
TECPR2 tectonin beta-propeller repeat containing 2 -0.0170675
POM121C POM121 transmembrane nucleoporin C -0.0170378
SECISBP2 SECIS binding protein 2 -0.0169993
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 -0.0169693
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0169666
CTSB cathepsin B -0.0169532
FAF2 Fas associated factor family member 2 -0.0169209
WDR26 WD repeat domain 26 -0.016904
KANK1 KN motif and ankyrin repeat domains 1 -0.0168469
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 -0.0167887
GFM1 G elongation factor, mitochondrial 1 -0.0167373
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0166881
HSPG2 heparan sulfate proteoglycan 2 -0.0166869
ZNRF3 zinc and ring finger 3 -0.0166607
RPL39 ribosomal protein L39 -0.0166424
RBM6 RNA binding motif protein 6 -0.0166311
ATP11A ATPase, class VI, type 11A -0.0166234
TTC39C tetratricopeptide repeat domain 39C -0.0166083
DOCK10 dedicator of cytokinesis 10 -0.0165999
BRD4 bromodomain containing 4 -0.0165971
TBCD tubulin folding cofactor D -0.0165837
ITFG2 integrin alpha FG-GAP repeat containing 2 -0.0165834
CNTN1 contactin 1 -0.0165748
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0165482
AFF4 AF4/FMR2 family, member 4 -0.0165419
PROC protein C (inactivator of coagulation factors Va and VIIIa) -0.0164822
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.016481
LDLR low density lipoprotein receptor -0.0164412
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase -0.016422
RPL19 ribosomal protein L19 -0.0164165
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0163874
KDSR 3-ketodihydrosphingosine reductase -0.0163415
RORA RAR-related orphan receptor A -0.0163085
PLIN4 perilipin 4 -0.0162951
GPR107 G protein-coupled receptor 107 -0.0162583
PSPH phosphoserine phosphatase -0.0162578
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 -0.0162433
PUS7 pseudouridylate synthase 7 (putative) -0.0162273
SEPTIN9 septin 9 -0.0162196
ARHGAP32 Rho GTPase activating protein 32 -0.0162154
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.016156
ASXL1 additional sex combs like transcriptional regulator 1 -0.0161136
SCARB1 scavenger receptor class B, member 1 -0.0161043
SMAD3 SMAD family member 3 -0.0160827
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11 -0.0160812
CPPED1 calcineurin-like phosphoesterase domain containing 1 -0.0160762
OTUD5 OTU deubiquitinase 5 -0.0160655
FHIT fragile histidine triad -0.0160239
CRTC1 CREB regulated transcription coactivator 1 -0.0160225
LUC7L LUC7-like (S. cerevisiae) -0.0159914
HACD1 3-hydroxyacyl-CoA dehydratase 1 -0.0159851
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme -0.0159518
SSH1 slingshot protein phosphatase 1 -0.0158812
UGDH UDP-glucose 6-dehydrogenase -0.0158733
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) -0.0158556
CFLAR CASP8 and FADD-like apoptosis regulator -0.0158375
ARHGAP1 Rho GTPase activating protein 1 -0.0158175
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0158125
MEF2A myocyte enhancer factor 2A -0.0157997
DNPEP aspartyl aminopeptidase -0.0157652
UIMC1 ubiquitin interaction motif containing 1 -0.0157601
UBE2E1 ubiquitin-conjugating enzyme E2E 1 -0.015721
SOAT1 sterol O-acyltransferase 1 -0.0156677
RABL6 RAB, member RAS oncogene family-like 6 -0.0156639
WDR41 WD repeat domain 41 -0.0156608
KIFC3 kinesin family member C3 -0.0156571
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.0156485
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0156442
ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10 -0.0156378
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0156351
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 -0.0156342
UGCG UDP-glucose ceramide glucosyltransferase -0.0156308
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0155956
SOCS5 suppressor of cytokine signaling 5 -0.0155162
XRN1 5'-3' exoribonuclease 1 -0.0154975
PTPN2 protein tyrosine phosphatase, non-receptor type 2 -0.0154579
DNM1 dynamin 1 -0.0154559
BICDL1 BICD family like cargo adaptor 1 -0.0154405
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 -0.0154264
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0154184
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 -0.0154179
TMOD3 tropomodulin 3 (ubiquitous) -0.0154052
LGALS8 lectin, galactoside-binding, soluble, 8 -0.0154043
ZNF652 zinc finger protein 652 -0.0154034
EGR1 early growth response 1 -0.0154034
DENND6A DENN/MADD domain containing 6A -0.0153987
ADIPOR2 adiponectin receptor 2 -0.0153967
UBAC2 UBA domain containing 2 -0.0153908
IPO9 importin 9 -0.0153842
USP34 ubiquitin specific peptidase 34 -0.0153273
FBXW2 F-box and WD repeat domain containing 2 -0.0153136
SEC11A SEC11 homolog A (S. cerevisiae) -0.0153064
ZNF33A zinc finger protein 33A -0.0152887
PRTG protogenin -0.0152887
EIF3K eukaryotic translation initiation factor 3, subunit K -0.0152769
USP47 ubiquitin specific peptidase 47 -0.0152753
FUBP1 far upstream element (FUSE) binding protein 1 -0.0152752
HOOK3 hook microtubule-tethering protein 3 -0.015255
SNX6 sorting nexin 6 -0.0152512
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0152413
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -0.0152247
KLHL29 kelch-like family member 29 -0.0152215
PDE4D phosphodiesterase 4D, cAMP-specific -0.0151788
NCOA1 nuclear receptor coactivator 1 -0.0151613
SYAP1 synapse associated protein 1 -0.0151421
AHCY adenosylhomocysteinase -0.0151202
STXBP4 syntaxin binding protein 4 -0.0151194
THSD7A thrombospondin, type I, domain containing 7A -0.0150947
ZMYM2 zinc finger, MYM-type 2 -0.0150764
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa -0.0150713
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0150661
AK2 adenylate kinase 2 -0.0150636
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0150153
VARS1 valyl-tRNA synthetase 1 -0.0150099
ZNF787 zinc finger protein 787 -0.0150063
COQ8B coenzyme Q8B -0.0150025
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0149881
PTEN phosphatase and tensin homolog -0.0149806
AARS1 alanyl-tRNA synthetase 1 -0.0149791
USP32 ubiquitin specific peptidase 32 -0.0149582
BSG basigin (Ok blood group) -0.0149463