A549_Obatoclax Mesylate_10nM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description Obatoclax Mesylate 10nM perturbation in A549 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the A549_Obatoclax Mesylate_10nM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.144614
AKR1C2 aldo-keto reductase family 1, member C2 0.134295
ENO1 enolase 1, (alpha) 0.0891562
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.0890497
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.0773955
KRT8 keratin 8, type II 0.0762011
AKR1C3 aldo-keto reductase family 1, member C3 0.0744514
KRT18 keratin 18, type I 0.0703262
ABTB3 ankyrin repeat and BTB domain containing 3 0.0699759
TXNRD1 thioredoxin reductase 1 0.0669302
S100A10 S100 calcium binding protein A10 0.066355
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0631139
KRT81 keratin 81, type II 0.0629764
FTL ferritin, light polypeptide 0.0606225
NRCAM neuronal cell adhesion molecule 0.060574
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0589997
PKM pyruvate kinase, muscle 0.0587244
RPS2 ribosomal protein S2 0.0580552
CLU clusterin 0.0550813
IGF1R insulin-like growth factor 1 receptor 0.0537033
TLN1 talin 1 0.0517121
FAF1 Fas (TNFRSF6) associated factor 1 0.0505332
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0490794
MYO1E myosin IE 0.0487306
ASPH aspartate beta-hydroxylase 0.0477672
PBX1 pre-B-cell leukemia homeobox 1 0.0473931
VEZT vezatin, adherens junctions transmembrane protein 0.0464227
RAD51B RAD51 paralog B 0.0458332
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.0456228
MRPL13 mitochondrial ribosomal protein L13 0.0450445
TKT transketolase 0.0420759
EIF5B eukaryotic translation initiation factor 5B 0.0416394
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 0.0414002
DST dystonin 0.041231
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.040496
PRRC2C proline-rich coiled-coil 2C 0.0403812
BRCA1 breast cancer 1, early onset 0.0401161
PCDHB16 protocadherin beta 16 0.0398752
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0391514
CEP128 centrosomal protein 128kDa 0.0388424
VIM vimentin 0.0380176
POTEF POTE ankyrin domain family, member F 0.0377151
PRKCE protein kinase C, epsilon 0.0375524
ATAD2 ATPase family, AAA domain containing 2 0.0362223
RTN4 reticulon 4 0.0361498
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 0.0358943
RPL13A ribosomal protein L13a 0.0353488
DENND5B DENN/MADD domain containing 5B 0.0346779
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0346104
DSG2 desmoglein 2 0.0345601
METTL15 methyltransferase like 15 0.0344267
PHGDH phosphoglycerate dehydrogenase 0.0337565
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 0.0337184
HACD3 3-hydroxyacyl-CoA dehydratase 3 0.033596
SET SET nuclear proto-oncogene 0.033588
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0333518
MKI67 marker of proliferation Ki-67 0.033241
KATNBL1 katanin p80 subunit B-like 1 0.0331856
UBE2G1 ubiquitin-conjugating enzyme E2G 1 0.0327404
TAGLN2 transgelin 2 0.0327242
HDGF hepatoma-derived growth factor 0.0326775
GLIS3 GLIS family zinc finger 3 0.0326442
SYT1 synaptotagmin I 0.0322044
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0322041
PFN1 profilin 1 0.0319287
IQGAP1 IQ motif containing GTPase activating protein 1 0.0311266
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0310723
CMIP c-Maf inducing protein 0.0307275
RPS19 ribosomal protein S19 0.030476
PLCH1 phospholipase C, eta 1 0.0304363
PTMA prothymosin, alpha 0.0302618
CLTC clathrin, heavy chain (Hc) 0.0301812
RPL38 ribosomal protein L38 0.030046
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0297793
TMSB10 thymosin beta 10 0.0296066
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.029294
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0291162
HCFC1 host cell factor C1 0.0291103
RPL30 ribosomal protein L30 0.0289515
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.0289178
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0285539
RPL8 ribosomal protein L8 0.0283751
ACLY ATP citrate lyase 0.0280944
COL5A2 collagen, type V, alpha 2 0.027899
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 0.0277577
SLC35F3 solute carrier family 35, member F3 0.0275813
MAGT1 magnesium transporter 1 0.0273727
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0272846
VDAC2 voltage-dependent anion channel 2 0.0272158
AGFG1 ArfGAP with FG repeats 1 0.0270846
RPLP2 ribosomal protein, large, P2 0.0270551
ATAD5 ATPase family, AAA domain containing 5 0.0269142
ILF3 interleukin enhancer binding factor 3, 90kDa 0.0269103
RPL39 ribosomal protein L39 0.0268528
MARCHF7 membrane associated ring-CH-type finger 7 0.0268478
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0261
S100A6 S100 calcium binding protein A6 0.0260099
GCLC glutamate-cysteine ligase, catalytic subunit 0.0259706
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0259458
NUP98 nucleoporin 98kDa 0.0259112
ANXA2 annexin A2 0.0259066
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0258366
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.0257413
TCOF1 Treacher Collins-Franceschetti syndrome 1 0.0254673
CCT7 chaperonin containing TCP1, subunit 7 (eta) 0.0254333
DSPP dentin sialophosphoprotein 0.0253494
TBC1D5 TBC1 domain family, member 5 0.0253072
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.0252879
KPNB1 karyopherin (importin) beta 1 0.0252482
NIPBL Nipped-B homolog (Drosophila) 0.0249494
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0249198
DOCK10 dedicator of cytokinesis 10 0.024894
CCDC88A coiled-coil domain containing 88A 0.0248612
LDHB lactate dehydrogenase B 0.0248247
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0248165
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0247559
PANK2 pantothenate kinase 2 0.0247522
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0244985
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0244472
AFF4 AF4/FMR2 family, member 4 0.0244267
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0243375
DPEP2 dipeptidase 2 0.0243197
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0242477
CENPF centromere protein F, 350/400kDa 0.0242159
SLC35E3 solute carrier family 35, member E3 0.0241798
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) 0.0241627
PTGR1 prostaglandin reductase 1 0.0241135
MUSK muscle, skeletal, receptor tyrosine kinase 0.0240181
KIF2A kinesin heavy chain member 2A 0.0239934
ARHGAP11B Rho GTPase activating protein 11B 0.0238543
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0238102
ZMYND8 zinc finger, MYND-type containing 8 0.0237961
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 0.0237417
S100A4 S100 calcium binding protein A4 0.0236253
RFWD3 ring finger and WD repeat domain 3 0.0235588
PDE7B phosphodiesterase 7B 0.0235403
ANO6 anoctamin 6 0.023534
RHOA ras homolog family member A 0.0234208
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0233956
RPLP1 ribosomal protein, large, P1 0.023347
CD44 CD44 molecule (Indian blood group) 0.0232494
HMGB1 high mobility group box 1 0.023196
FADS2 fatty acid desaturase 2 0.0228674
LAMP2 lysosomal-associated membrane protein 2 0.0227654
FBXO11 F-box protein 11 0.02263
CCND1 cyclin D1 0.0226039
GSTP1 glutathione S-transferase pi 1 0.0225487
RSL1D1 ribosomal L1 domain containing 1 0.0224785
SLTM SAFB-like, transcription modulator 0.0224711
MPG N-methylpurine-DNA glycosylase 0.0224664
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 0.0223057
MICU1 mitochondrial calcium uptake 1 0.0222974
TUBA1C tubulin, alpha 1c 0.0222849
PTCD3 pentatricopeptide repeat domain 3 0.0222099
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0221483
MSRB3 methionine sulfoxide reductase B3 0.0221177
SERBP1 SERPINE1 mRNA binding protein 1 0.0220782
SENP6 SUMO1/sentrin specific peptidase 6 0.0220496
RHOBTB1 Rho-related BTB domain containing 1 0.0220276
OAZ1 ornithine decarboxylase antizyme 1 0.0219622
IMMT inner membrane protein, mitochondrial 0.0217903
FLNA filamin A, alpha 0.0216801
SEPTIN11 septin 11 0.0216288
CERS6 ceramide synthase 6 0.0216182
AP3D1 adaptor-related protein complex 3, delta 1 subunit 0.0215051
MCM4 minichromosome maintenance complex component 4 0.0214902
CLIP1 CAP-GLY domain containing linker protein 1 0.0214751
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.021453
FBL fibrillarin 0.0214256
CDC37 cell division cycle 37 0.0213854
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0213597
RRBP1 ribosome binding protein 1 0.0213297
HFE hemochromatosis 0.0213092
SRRM1 serine/arginine repetitive matrix 1 0.0213008
SEPTIN10 septin 10 0.0212322
LARP1 La ribonucleoprotein domain family, member 1 0.0211496
NUP62 nucleoporin 62kDa 0.0210676
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0210415
MIS18BP1 MIS18 binding protein 1 0.0210262
MLEC malectin 0.0209468
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0209229
ANXA1 annexin A1 0.020849
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0208125
MCM6 minichromosome maintenance complex component 6 0.0207916
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0207431
RNF13 ring finger protein 13 0.0207278
IFT81 intraflagellar transport 81 0.0206933
LCOR ligand dependent nuclear receptor corepressor 0.0206808
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.0206682
NPEPPS aminopeptidase puromycin sensitive 0.0206561
SDC1 syndecan 1 0.0206082
RABEP1 rabaptin, RAB GTPase binding effector protein 1 0.0205907
SNF8 SNF8, ESCRT-II complex subunit 0.0205659
NOP2 NOP2 nucleolar protein 0.0204673
STRBP spermatid perinuclear RNA binding protein 0.0204299
CARD8 caspase recruitment domain family, member 8 0.0204235
QSER1 glutamine and serine rich 1 0.0203999
TUFM Tu translation elongation factor, mitochondrial 0.0202818
SETX senataxin 0.0202027
CENPK centromere protein K 0.0201623
UBB ubiquitin B 0.0201531
TK1 thymidine kinase 1, soluble 0.0201481
TPI1 triosephosphate isomerase 1 0.0201357
TMPO thymopoietin 0.0201294
USP1 ubiquitin specific peptidase 1 0.0200755
DIAPH1 diaphanous-related formin 1 0.0200663
IPO7 importin 7 0.0200569
RPS27A ribosomal protein S27a 0.0200293
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) 0.0200006
GNAS GNAS complex locus 0.019962
UBXN4 UBX domain protein 4 0.0198824
CCND3 cyclin D3 0.0198663
BICD1 bicaudal D homolog 1 (Drosophila) 0.0198496
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0198202
SEPTIN7 septin 7 0.0198001
PFAS phosphoribosylformylglycinamidine synthase 0.0197827
GOLIM4 golgi integral membrane protein 4 0.0197434
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0197361
SKA2 spindle and kinetochore associated complex subunit 2 0.0197025
UBA6 ubiquitin-like modifier activating enzyme 6 0.0196404
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0194985
ARRB1 arrestin, beta 1 0.0194213
NCAPD2 non-SMC condensin I complex, subunit D2 0.019416
NRIP1 nuclear receptor interacting protein 1 0.0193802
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.019357
TUBB4B tubulin, beta 4B class IVb 0.0193453
USP48 ubiquitin specific peptidase 48 0.019332
VCAN versican 0.01932
FBXO34 F-box protein 34 0.0192801
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0192364
EIPR1 EARP complex and GARP complex interacting protein 1 0.0191742
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) 0.0191255
UBC ubiquitin C 0.0190965
RNF43 ring finger protein 43 0.0189958
UBL4A ubiquitin-like 4A 0.0189706
AHCTF1 AT hook containing transcription factor 1 0.0189597
MBTD1 mbt domain containing 1 0.018936
MAP4 microtubule-associated protein 4 0.0189288
PCLAF PCNA clamp associated factor 0.0189146
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 0.0188873
RABGAP1 RAB GTPase activating protein 1 0.0188804
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0188422
ASXL2 additional sex combs like transcriptional regulator 2 0.0188323
RNASEH1 ribonuclease H1 0.0188317
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic) 0.0188113
RPS8 ribosomal protein S8 0.0186679
PKN1 protein kinase N1 0.0186522
CENPP centromere protein P 0.0186276
MRPL41 mitochondrial ribosomal protein L41 0.0185808
RBBP7 retinoblastoma binding protein 7 0.0185793
AHCYL1 adenosylhomocysteinase-like 1 0.0185587
RRM1 ribonucleotide reductase M1 0.0185534
WDR33 WD repeat domain 33 0.018544
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0185142
HP1BP3 heterochromatin protein 1, binding protein 3 0.0184807
CANX calnexin 0.0184373
API5 apoptosis inhibitor 5 0.018432
THRAP3 thyroid hormone receptor associated protein 3 0.0184319
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0184169
RPRD1A regulation of nuclear pre-mRNA domain containing 1A 0.0184061
RPS17 ribosomal protein S17 0.0183937
TM4SF1 transmembrane 4 L six family member 1 0.0183936
PCM1 pericentriolar material 1 0.0183727
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 0.0182806
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.0182718
DYNLL2 dynein, light chain, LC8-type 2 0.0182231
ZFR zinc finger RNA binding protein 0.0181062
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0180191
TGOLN2 trans-golgi network protein 2 0.0178588
RPS7 ribosomal protein S7 0.0178138
PCNX2 pecanex 2 0.0178063
PLS1 plastin 1 0.0177277
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0176803
RANBP2 RAN binding protein 2 0.0176713
LRIF1 ligand dependent nuclear receptor interacting factor 1 0.0176389
CHN1 chimerin 1 0.0176337
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0176292
PHPT1 phosphohistidine phosphatase 1 0.0176061
BARD1 BRCA1 associated RING domain 1 0.0175924
FLII flightless I homolog (Drosophila) 0.0175192
ZSCAN5A zinc finger and SCAN domain containing 5A 0.0175123
KNL1 kinetochore scaffold 1 0.017504
CLSPN claspin 0.0174651
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1 0.0174401
CCAR1 cell division cycle and apoptosis regulator 1 0.0174348
TBC1D31 TBC1 domain family, member 31 0.0173855
FAT1 FAT atypical cadherin 1 0.0173223
HACD2 3-hydroxyacyl-CoA dehydratase 2 0.0172947
DNA2 DNA replication helicase/nuclease 2 0.0172692
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 0.0172476
MACF1 microtubule-actin crosslinking factor 1 0.0171282
WDR70 WD repeat domain 70 0.0171127
RPS15 ribosomal protein S15 0.0171091
MRC2 mannose receptor, C type 2 0.0170699
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0170654
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 0.0170391
TMEM135 transmembrane protein 135 0.017021
TGFBR3 transforming growth factor, beta receptor III 0.0169618
SAAL1 serum amyloid A-like 1 0.0168782
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.0168708
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0168668
IQGAP2 IQ motif containing GTPase activating protein 2 0.016845
NACA nascent polypeptide-associated complex alpha subunit 0.0167712
IL18 interleukin 18 0.0167681
ATL3 atlastin GTPase 3 0.0167648
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.01675
H1-3 H1.3 linker histone, cluster member 0.0167281
HJURP Holliday junction recognition protein 0.016723
KIF21A kinesin family member 21A 0.0167147
KIAA0586 KIAA0586 0.0166724
TOPBP1 topoisomerase (DNA) II binding protein 1 0.0166416
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0165976
PRIM2 primase, DNA, polypeptide 2 (58kDa) 0.016522
OGA O-GlcNAcase 0.0165204
MAPK1 mitogen-activated protein kinase 1 0.0165128
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12 0.0164766
ANAPC7 anaphase promoting complex subunit 7 0.0164762
NONO non-POU domain containing, octamer-binding 0.0164726
PDCD6IP programmed cell death 6 interacting protein 0.0164689
KDM1A lysine (K)-specific demethylase 1A 0.0164606
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits 0.016391
DOCK5 dedicator of cytokinesis 5 0.0163801
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 0.0163719
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) 0.0163421
RBM41 RNA binding motif protein 41 0.0162713
QRICH1 glutamine-rich 1 0.0162555
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.016214
NUAK1 NUAK family, SNF1-like kinase, 1 0.0162067
CKAP2 cytoskeleton associated protein 2 0.0162043
PUM1 pumilio RNA-binding family member 1 0.0161994
LRP6 low density lipoprotein receptor-related protein 6 0.0161924
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa 0.0161737
TPM3 tropomyosin 3 0.0161647
SUCO SUN domain containing ossification factor 0.0161161
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 0.0161147
CORO1B coronin, actin binding protein, 1B 0.0161002
KIAA2026 KIAA2026 0.016066
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 0.016063
SRSF11 serine/arginine-rich splicing factor 11 0.0160519
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0160031
HDGFL3 HDGF like 3 0.0159842
WNT7B wingless-type MMTV integration site family, member 7B 0.0159563
SMC4 structural maintenance of chromosomes 4 0.0159346
FAM50A family with sequence similarity 50, member A 0.0158931
GAB2 GRB2-associated binding protein 2 0.0158551
RPL29 ribosomal protein L29 0.0158508
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0158443
KMT2E lysine (K)-specific methyltransferase 2E 0.015831
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.015792
B9D1 B9 protein domain 1 0.0157751
FAM210B family with sequence similarity 210, member B 0.015754
ATRAID all-trans retinoic acid-induced differentiation factor 0.0157414
TRIM28 tripartite motif containing 28 0.015716
TGIF1 TGFB-induced factor homeobox 1 0.0157126
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0156785
TGFB2 transforming growth factor, beta 2 0.0156777
RBM20 RNA binding motif protein 20 0.015652
NCAPH non-SMC condensin I complex, subunit H 0.0156367
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3 0.0156296
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0156153
CHMP2A charged multivesicular body protein 2A 0.0156043
NAP1L4 nucleosome assembly protein 1-like 4 0.0155949
RNF121 ring finger protein 121 0.0155909
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2 0.015562
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0155426
DSCAM Down syndrome cell adhesion molecule 0.015534
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 0.0155321
RPL11 ribosomal protein L11 0.0155261
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 0.0154563
EPAS1 endothelial PAS domain protein 1 0.015444
SOS1 son of sevenless homolog 1 (Drosophila) 0.0154061
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0154041
TYW1B tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae) 0.0153808
ICE2 interactor of little elongation complex ELL subunit 2 0.0153287
PTMS parathymosin 0.0153163
RAB33B RAB33B, member RAS oncogene family 0.0152544
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 0.0152389
CTPS1 CTP synthase 1 0.0152294
RPL34 ribosomal protein L34 0.0152289
NAP1L1 nucleosome assembly protein 1-like 1 0.0152062
FBXO5 F-box protein 5 0.0151957
MAP3K11 mitogen-activated protein kinase kinase kinase 11 0.0151634
USP9X ubiquitin specific peptidase 9, X-linked 0.0151599
PARN poly(A)-specific ribonuclease 0.0151184
MORF4L2 mortality factor 4 like 2 0.0150973
KCTD1 potassium channel tetramerization domain containing 1 0.0150867
GPC1 glypican 1 0.0150396
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.014958
NKTR natural killer cell triggering receptor 0.0149422
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0148841
FSTL3 follistatin-like 3 (secreted glycoprotein) 0.0148775
BBX bobby sox homolog (Drosophila) 0.0148492
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein 0.0148467
SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 0.0148402
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa 0.014819
CPSF3 cleavage and polyadenylation specific factor 3, 73kDa 0.0148145
CDCA2 cell division cycle associated 2 0.0147518
TRAPPC8 trafficking protein particle complex 8 0.0147338
SFTPA2 surfactant protein A2 0.014697
BCAS3 breast carcinoma amplified sequence 3 0.0146752
RPS3 ribosomal protein S3 0.01465
RPS5 ribosomal protein S5 0.0146282
SPNS1 spinster homolog 1 (Drosophila) 0.0145883
STK32B serine/threonine kinase 32B 0.0145657
ITFG1 integrin alpha FG-GAP repeat containing 1 0.0145584
FAM168B family with sequence similarity 168, member B 0.0145428
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae) 0.0145388
SLIT3 slit homolog 3 (Drosophila) 0.0145087
SOCS4 suppressor of cytokine signaling 4 0.0144726
DIAPH3 diaphanous-related formin 3 0.0144423
MSH6 mutS homolog 6 0.0144295
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 0.0144145
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 0.0144081
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 0.014398
TMX1 thioredoxin-related transmembrane protein 1 0.0143963
TMEM209 transmembrane protein 209 0.014394
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0143913
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0143701
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 0.0143357
TSKU tsukushi, small leucine rich proteoglycan 0.0142843
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 0.0142446
DZIP1 DAZ interacting zinc finger protein 1 0.0142385
ZC3H13 zinc finger CCCH-type containing 13 0.0142301
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 0.0142272
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 0.0142211
RASSF3 Ras association (RalGDS/AF-6) domain family member 3 0.0141948
FDPS farnesyl diphosphate synthase 0.0141748
M6PR mannose-6-phosphate receptor (cation dependent) 0.0141748
CS citrate synthase 0.0141473
IFRD2 interferon-related developmental regulator 2 0.0141184
JOSD2 Josephin domain containing 2 0.0140905
PRXL2A peroxiredoxin like 2A 0.0140759
NOP56 NOP56 ribonucleoprotein 0.0140726
LDAH lipid droplet associated hydrolase 0.014057
BCLAF1 BCL2-associated transcription factor 1 0.0140456
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 0.0140438
STMN1 stathmin 1 0.0140048
WASL Wiskott-Aldrich syndrome-like 0.013999
VKORC1L1 vitamin K epoxide reductase complex, subunit 1-like 1 0.0139916
ECPAS Ecm29 proteasome adaptor and scaffold 0.0139855
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 0.0139416
PIGU phosphatidylinositol glycan anchor biosynthesis, class U 0.0139396
BRI3BP BRI3 binding protein 0.0139195
PRDX4 peroxiredoxin 4 0.0139074
CEP152 centrosomal protein 152kDa 0.0139032
WDR36 WD repeat domain 36 0.0138873
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0138707
USP47 ubiquitin specific peptidase 47 0.0138666
SRSF7 serine/arginine-rich splicing factor 7 0.0138659
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) 0.0138613
SSB Sjogren syndrome antigen B (autoantigen La) 0.0138419
LCLAT1 lysocardiolipin acyltransferase 1 0.0138361
TM4SF20 transmembrane 4 L six family member 20 0.0137965
OCIAD1 OCIA domain containing 1 0.0137767
BMS1 BMS1 ribosome biogenesis factor 0.0137434
DBF4B DBF4 zinc finger B 0.0137351
DNAH14 dynein, axonemal, heavy chain 14 0.0137272
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0136985
INTS7 integrator complex subunit 7 0.0136772
POLA2 polymerase (DNA directed), alpha 2, accessory subunit 0.0136704
CDC73 cell division cycle 73 0.0136641
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0136414
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 0.0136286
THAP12 THAP domain containing 12 0.0136279
GJD3 gap junction protein, delta 3, 31.9kDa 0.0136204
SQSTM1 sequestosome 1 0.0136188
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0136135
POGLUT3 protein O-glucosyltransferase 3 0.0136076
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0135914
ITPK1 inositol-tetrakisphosphate 1-kinase 0.013584
CYBC1 cytochrome b-245 chaperone 1 0.0135686
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 0.0135535
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) 0.0135524
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.013532
KLHL8 kelch-like family member 8 0.0135256
ZFHX4 zinc finger homeobox 4 0.0135213
PLCE1 phospholipase C, epsilon 1 0.0135194
KIF20B kinesin family member 20B 0.0135135
IGFBP3 insulin-like growth factor binding protein 3 0.0135041
ZNF770 zinc finger protein 770 0.013502
CCDC138 coiled-coil domain containing 138 0.0134993
KIAA1958 KIAA1958 0.0134898
IER5L immediate early response 5-like 0.0134798
HNRNPF heterogeneous nuclear ribonucleoprotein F 0.0134757
TUBA1A tubulin, alpha 1a 0.0134283
KCTD3 potassium channel tetramerization domain containing 3 0.0134235
SEC23IP SEC23 interacting protein 0.013421
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0134131
TRIM44 tripartite motif containing 44 0.0133763
UBE2L3 ubiquitin-conjugating enzyme E2L 3 0.013329
RPL19 ribosomal protein L19 0.0133029
CCT2 chaperonin containing TCP1, subunit 2 (beta) 0.013288
NSFL1C NSFL1 (p97) cofactor (p47) 0.0132682
DGKD diacylglycerol kinase, delta 130kDa 0.0132611
LZIC leucine zipper and CTNNBIP1 domain containing 0.013253
SP3 Sp3 transcription factor 0.0132495
UBN1 ubinuclein 1 0.0132394
ZNF33B zinc finger protein 33B 0.0132355
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa 0.0132325
HSPH1 heat shock 105kDa/110kDa protein 1 0.0132168

decreased expression

Symbol Name Standardized Value
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.128023
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.106364
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.101431
ARHGAP26 Rho GTPase activating protein 26 -0.0768332
PDE10A phosphodiesterase 10A -0.0734812
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.072023
FAM107B family with sequence similarity 107, member B -0.071211
PDLIM5 PDZ and LIM domain 5 -0.069487
PPP1R9A protein phosphatase 1, regulatory subunit 9A -0.0691802
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0683
CUX1 cut-like homeobox 1 -0.0677584
AKAP13 A kinase (PRKA) anchor protein 13 -0.0655454
FNDC3B fibronectin type III domain containing 3B -0.065286
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0612587
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.0589393
MYO10 myosin X -0.0584494
PDE4D phosphodiesterase 4D, cAMP-specific -0.0578474
NRG1 neuregulin 1 -0.0573046
HIP1 huntingtin interacting protein 1 -0.0508752
BMPR1B bone morphogenetic protein receptor, type IB -0.0505905
CNTNAP3B contactin associated protein-like 3B -0.0505862
USP32 ubiquitin specific peptidase 32 -0.0494431
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0488869
EXT1 exostosin glycosyltransferase 1 -0.048139
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.047121
ZNF609 zinc finger protein 609 -0.0467587
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.045984
JUP junction plakoglobin -0.045724
COP1 COP1 E3 ubiquitin ligase -0.0451249
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 -0.0429588
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0428047
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0423386
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0419425
PRKCA protein kinase C, alpha -0.0417426
C5 complement component 5 -0.041533
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0413658
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0413066
CCDC91 coiled-coil domain containing 91 -0.0412565
MRTFA myocardin related transcription factor A -0.0406658
USP34 ubiquitin specific peptidase 34 -0.0406085
APP amyloid beta (A4) precursor protein -0.04016
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0399233
MED13L mediator complex subunit 13-like -0.0396937
LRMDA leucine rich melanocyte differentiation associated -0.039448
NTN4 netrin 4 -0.0393418
ARL15 ADP-ribosylation factor-like 15 -0.039246
CUEDC1 CUE domain containing 1 -0.0391547
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -0.038946
PPP1R13B protein phosphatase 1, regulatory subunit 13B -0.0388743
ANKRD11 ankyrin repeat domain 11 -0.0382506
CNTN1 contactin 1 -0.0379362
ATXN2 ataxin 2 -0.0372151
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.037195
AOPEP aminopeptidase O (putative) -0.0371578
CTBP2 C-terminal binding protein 2 -0.0369261
MTUS1 microtubule associated tumor suppressor 1 -0.0367235
GRAMD1B GRAM domain containing 1B -0.0366424
TBL1X transducin (beta)-like 1X-linked -0.0360088
KDM2A lysine (K)-specific demethylase 2A -0.0359823
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0357437
PLD5 phospholipase D family, member 5 -0.0357046
SPAG9 sperm associated antigen 9 -0.0356711
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0353462
AGR2 anterior gradient 2 -0.0351366
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0350888
PTPRK protein tyrosine phosphatase, receptor type, K -0.0350729
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0350387
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0348976
SBNO1 strawberry notch homolog 1 (Drosophila) -0.0348311
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0344891
RBM47 RNA binding motif protein 47 -0.0344765
IRS2 insulin receptor substrate 2 -0.0344403
UGDH UDP-glucose 6-dehydrogenase -0.0343186
TTC28 tetratricopeptide repeat domain 28 -0.0342991
ARHGAP5 Rho GTPase activating protein 5 -0.0342449
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0342235
METTL16 methyltransferase like 16 -0.0328911
CCDC57 coiled-coil domain containing 57 -0.0325399
KMT2A lysine (K)-specific methyltransferase 2A -0.0323369
TAOK3 TAO kinase 3 -0.0323251
PDE7A phosphodiesterase 7A -0.032323
CYRIB CYFIP related Rac1 interactor B -0.0322662
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0320198
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0318931
FAM222B family with sequence similarity 222, member B -0.031721
FOXP1 forkhead box P1 -0.0316755
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0314701
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0312444
COL4A5 collagen, type IV, alpha 5 -0.0305324
ITSN2 intersectin 2 -0.0305318
NUMB numb homolog (Drosophila) -0.0304936
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0304466
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0304304
TAOK1 TAO kinase 1 -0.0303178
SEPTIN9 septin 9 -0.0303007
FAM177A1 family with sequence similarity 177, member A1 -0.0300679
ADGRG6 adhesion G protein-coupled receptor G6 -0.0300638
UBE3C ubiquitin protein ligase E3C -0.0300566
THSD4 thrombospondin, type I, domain containing 4 -0.029905
DOCK1 dedicator of cytokinesis 1 -0.0298142
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0296142
ENSA endosulfine alpha -0.0294685
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -0.0294014
AKAP12 A kinase (PRKA) anchor protein 12 -0.0293833
WNK1 WNK lysine deficient protein kinase 1 -0.0292421
TNRC18 trinucleotide repeat containing 18 -0.0291645
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0291061
WDR44 WD repeat domain 44 -0.0290393
MYO1D myosin ID -0.0289924
TSC22D1 TSC22 domain family, member 1 -0.0289833
RAB1A RAB1A, member RAS oncogene family -0.028942
MAP7 microtubule-associated protein 7 -0.0288964
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0288118
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0287556
JMJD1C jumonji domain containing 1C -0.0285637
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0283523
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0282672
PUM2 pumilio RNA-binding family member 2 -0.0281993
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0281286
VPS35L VPS35 endosomal protein sorting factor like -0.0280873
ADAM10 ADAM metallopeptidase domain 10 -0.0280672
PCYOX1 prenylcysteine oxidase 1 -0.0279638
LIMCH1 LIM and calponin homology domains 1 -0.0276706
PLD3 phospholipase D family, member 3 -0.0275929
PPP1R21 protein phosphatase 1, regulatory subunit 21 -0.0275487
EYA4 EYA transcriptional coactivator and phosphatase 4 -0.0274731
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0274335
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0274248
PTK2 protein tyrosine kinase 2 -0.0274227
BRD4 bromodomain containing 4 -0.0272525
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0272299
CUL4A cullin 4A -0.0270591
FGB fibrinogen beta chain -0.0270022
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial) -0.0267612
STX8 syntaxin 8 -0.0265879
MYADM myeloid-associated differentiation marker -0.0265733
PDE4B phosphodiesterase 4B, cAMP-specific -0.0265525
PTPRM protein tyrosine phosphatase, receptor type, M -0.0263922
KLF5 Kruppel-like factor 5 (intestinal) -0.0263748
UBE2K ubiquitin-conjugating enzyme E2K -0.0262719
MTDH metadherin -0.0261662
ABR active BCR-related -0.0260774
KMT5B lysine methyltransferase 5B -0.0260022
EZR ezrin -0.0259584
SCAF8 SR-related CTD-associated factor 8 -0.0258494
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0258375
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.0255412
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 -0.025409
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 -0.025315
MPRIP myosin phosphatase Rho interacting protein -0.0252901
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0252036
BLTP2 bridge-like lipid transfer protein family member 2 -0.0251024
MSI2 musashi RNA-binding protein 2 -0.025037
ZBTB20 zinc finger and BTB domain containing 20 -0.0249883
FN1 fibronectin 1 -0.0249784
RPRD2 regulation of nuclear pre-mRNA domain containing 2 -0.0249569
UBA2 ubiquitin-like modifier activating enzyme 2 -0.0249301
FBXL20 F-box and leucine-rich repeat protein 20 -0.0248949
PRPF3 pre-mRNA processing factor 3 -0.0247644
ZNF652 zinc finger protein 652 -0.0247597
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -0.024745
GTF2IRD1 GTF2I repeat domain containing 1 -0.0246569
DNM1 dynamin 1 -0.0245373
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0243391
BMP6 bone morphogenetic protein 6 -0.024184
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 -0.0241731
RASAL2 RAS protein activator like 2 -0.0241077
TJP1 tight junction protein 1 -0.0240792
PTPRA protein tyrosine phosphatase, receptor type, A -0.0240003
LDLRAD3 low density lipoprotein receptor class A domain containing 3 -0.0239829
CP ceruloplasmin (ferroxidase) -0.0239581
GATAD2A GATA zinc finger domain containing 2A -0.023948
RAB2A RAB2A, member RAS oncogene family -0.0237463
WWOX WW domain containing oxidoreductase -0.0235043
SREBF2 sterol regulatory element binding transcription factor 2 -0.0233953
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0233159
INO80 INO80 complex subunit -0.0231703
LYPLA1 lysophospholipase I -0.0231676
PDE8B phosphodiesterase 8B -0.0231554
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0229242
TMEM41B transmembrane protein 41B -0.0228404
MAVS mitochondrial antiviral signaling protein -0.0227773
AMBRA1 autophagy/beclin-1 regulator 1 -0.0227039
CMTM8 CKLF-like MARVEL transmembrane domain containing 8 -0.0226758
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0226659
ARFGEF3 ARFGEF family member 3 -0.0226499
TPM1 tropomyosin 1 (alpha) -0.0226421
RCN1 reticulocalbin 1, EF-hand calcium binding domain -0.0226317
FMNL2 formin-like 2 -0.022558
ZNF638 zinc finger protein 638 -0.0225291
KPNA6 karyopherin alpha 6 (importin alpha 7) -0.0224573
CARMIL1 capping protein regulator and myosin 1 linker 1 -0.0223621
SERINC5 serine incorporator 5 -0.0222968
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase -0.0222761
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0222417
FBXW11 F-box and WD repeat domain containing 11 -0.0221539
GPX2 glutathione peroxidase 2 -0.0221268
L2HGDH L-2-hydroxyglutarate dehydrogenase -0.0220822
ARF4 ADP-ribosylation factor 4 -0.0220784
RPL37 ribosomal protein L37 -0.0219992
TMEM245 transmembrane protein 245 -0.0219513
SETD2 SET domain containing 2 -0.0219421
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0218468
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.021695
COL4A4 collagen, type IV, alpha 4 -0.0216049
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) -0.0215564
TRAF3 TNF receptor-associated factor 3 -0.0214414
KHSRP KH-type splicing regulatory protein -0.0213553
RNF111 ring finger protein 111 -0.021231
USP8 ubiquitin specific peptidase 8 -0.021198
LYRM4 LYR motif containing 4 -0.0211963
SIL1 SIL1 nucleotide exchange factor -0.0211723
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) -0.0211092
SLC39A11 solute carrier family 39, member 11 -0.0210726
TCP11L1 t-complex 11, testis-specific-like 1 -0.0210583
PTEN phosphatase and tensin homolog -0.0210421
ATG7 autophagy related 7 -0.0208618
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 -0.0208612
ANXA4 annexin A4 -0.0208582
PCDH9 protocadherin 9 -0.020803
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0208011
ARHGAP1 Rho GTPase activating protein 1 -0.0207756
PTPN2 protein tyrosine phosphatase, non-receptor type 2 -0.0207254
RCOR1 REST corepressor 1 -0.0206898
PRKCI protein kinase C, iota -0.0206632
CAVIN1 caveolae associated protein 1 -0.0206088
DENND4A DENN/MADD domain containing 4A -0.0205329
ATAD2B ATPase family, AAA domain containing 2B -0.020483
TACC2 transforming, acidic coiled-coil containing protein 2 -0.0204454
KIAA0319L KIAA0319-like -0.0204279
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -0.0204236
SCMH1 sex comb on midleg homolog 1 (Drosophila) -0.0203881
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -0.0203871
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0203575
ZSWIM7 zinc finger, SWIM-type containing 7 -0.0203369
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0203006
PATJ PATJ crumbs cell polarity complex component -0.0203002
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0202959
UEVLD UEV and lactate/malate dehyrogenase domains -0.020236
CFDP1 craniofacial development protein 1 -0.0201841
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0201715
ASXL1 additional sex combs like transcriptional regulator 1 -0.0200943
NEO1 neogenin 1 -0.0200695
CEP112 centrosomal protein 112kDa -0.0199838
SCAI suppressor of cancer cell invasion -0.0199301
FILIP1 filamin A interacting protein 1 -0.019805
GRB2 growth factor receptor-bound protein 2 -0.0197796
FAM168A family with sequence similarity 168, member A -0.0197662
LMAN1 lectin, mannose-binding, 1 -0.0197584
FHIT fragile histidine triad -0.0196968
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 -0.0196872
ALCAM activated leukocyte cell adhesion molecule -0.0196606
FBXL17 F-box and leucine-rich repeat protein 17 -0.0196428
MRTFB myocardin related transcription factor B -0.0196365
TMEM131 transmembrane protein 131 -0.0196341
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0195704
ZFAND3 zinc finger, AN1-type domain 3 -0.0195666
PSEN1 presenilin 1 -0.0195526
AUTS2 autism susceptibility candidate 2 -0.0194929
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0194448
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 -0.0194286
SYNRG synergin, gamma -0.0194038
TRIM37 tripartite motif containing 37 -0.0193965
MCM9 minichromosome maintenance complex component 9 -0.0193827
RORA RAR-related orphan receptor A -0.0193548
DSTN destrin (actin depolymerizing factor) -0.0193511
SMIM14 small integral membrane protein 14 -0.01935
FNDC3A fibronectin type III domain containing 3A -0.0193235
R3HDM1 R3H domain containing 1 -0.0192985
TFCP2 transcription factor CP2 -0.019291
DARS1 aspartyl-tRNA synthetase 1 -0.0190677
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma -0.0190357
FGA fibrinogen alpha chain -0.0189638
SNX25 sorting nexin 25 -0.0189552
PLPP1 phospholipid phosphatase 1 -0.0189516
ANKRD44 ankyrin repeat domain 44 -0.0189258
ERCC6L2 excision repair cross-complementation group 6-like 2 -0.0188678
CTTN cortactin -0.0188628
SOD2 superoxide dismutase 2, mitochondrial -0.0188442
MGLL monoglyceride lipase -0.0188212
POU2F1 POU class 2 homeobox 1 -0.0188161
SH3PXD2B SH3 and PX domains 2B -0.0187476
DUSP16 dual specificity phosphatase 16 -0.0187205
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0187031
GPRC5C G protein-coupled receptor, class C, group 5, member C -0.0186985
PHC3 polyhomeotic homolog 3 (Drosophila) -0.0186626
GPRIN3 GPRIN family member 3 -0.0186534
ABI1 abl-interactor 1 -0.0186038
ANKRD13D ankyrin repeat domain 13 family, member D -0.0185929
ZBTB7A zinc finger and BTB domain containing 7A -0.0185869
CLIP2 CAP-GLY domain containing linker protein 2 -0.0185805
BCL2L1 BCL2-like 1 -0.0185558
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0185311
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.018525
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0184662
USP53 ubiquitin specific peptidase 53 -0.0184512
FCGBP Fc fragment of IgG binding protein -0.0183786
STYXL1 serine/threonine/tyrosine interacting-like 1 -0.0183431
SOX4 SRY (sex determining region Y)-box 4 -0.0183388
RPL18 ribosomal protein L18 -0.0183308
PCED1B PC-esterase domain containing 1B -0.0183017
WDPCP WD repeat containing planar cell polarity effector -0.0182956
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0182263
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 -0.0182238
PLXND1 plexin D1 -0.0182238
ADAM17 ADAM metallopeptidase domain 17 -0.0181981
ACYP2 acylphosphatase 2, muscle type -0.0181626
EFNA5 ephrin-A5 -0.0181345
ZNF254 zinc finger protein 254 -0.0181337
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein -0.0181307
SPATA6L spermatogenesis associated 6-like -0.0181202
LPIN2 lipin 2 -0.0180991
RNF216 ring finger protein 216 -0.0180936
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0180931
LHFPL2 lipoma HMGIC fusion partner-like 2 -0.0180846
EGR1 early growth response 1 -0.0180618
ZFHX3 zinc finger homeobox 3 -0.0180568
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0180447
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34 -0.0180414
ZZZ3 zinc finger, ZZ-type containing 3 -0.0179888
SVIL supervillin -0.0179586
SNAP25 synaptosomal-associated protein, 25kDa -0.017926
LDHA lactate dehydrogenase A -0.0179245
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.017879
FNBP4 formin binding protein 4 -0.0178363
AMOTL1 angiomotin like 1 -0.0178105
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0178095
PAQR5 progestin and adipoQ receptor family member V -0.0177509
SREBF1 sterol regulatory element binding transcription factor 1 -0.0176998
VWA8 von Willebrand factor A domain containing 8 -0.0176888
KCMF1 potassium channel modulatory factor 1 -0.017678
ADNP activity-dependent neuroprotector homeobox -0.0176668
FLVCR1 feline leukemia virus subgroup C cellular receptor 1 -0.0176652
CEP290 centrosomal protein 290kDa -0.0176608
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0176483
EVA1C eva-1 homolog C (C. elegans) -0.0176251
SLC25A43 solute carrier family 25, member 43 -0.0176159
ORAI2 ORAI calcium release-activated calcium modulator 2 -0.0175935
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0175906
UBAP1 ubiquitin associated protein 1 -0.0175718
KMT2C lysine (K)-specific methyltransferase 2C -0.0175126
SH3RF1 SH3 domain containing ring finger 1 -0.017499
KCNT2 potassium channel, sodium activated subfamily T, member 2 -0.0174875
HMBOX1 homeobox containing 1 -0.0174786
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0174741
NCEH1 neutral cholesterol ester hydrolase 1 -0.01741
RPLP0 ribosomal protein, large, P0 -0.0174067
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0173878
SEC31A SEC31 homolog A (S. cerevisiae) -0.0172903
SYNGR2 synaptogyrin 2 -0.0172585
SLC38A2 solute carrier family 38, member 2 -0.0172273
CLDN2 claudin 2 -0.0171979
OXSR1 oxidative stress responsive 1 -0.017174
FBXL18 F-box and leucine-rich repeat protein 18 -0.0171696
NFE2L1 nuclear factor, erythroid 2-like 1 -0.0171456
ZYG11B zyg-11 family member B, cell cycle regulator -0.0171423
KLF3 Kruppel-like factor 3 (basic) -0.0171414
TMC5 transmembrane channel-like 5 -0.0171221
CADPS2 Ca++-dependent secretion activator 2 -0.0171054
TPX2 TPX2, microtubule-associated -0.0171054
PTPN3 protein tyrosine phosphatase, non-receptor type 3 -0.0170647
TMEM117 transmembrane protein 117 -0.0170606
SMAD2 SMAD family member 2 -0.0170317
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0169968
HNRNPLL heterogeneous nuclear ribonucleoprotein L-like -0.0169418
TECPR2 tectonin beta-propeller repeat containing 2 -0.0169364
ZNF644 zinc finger protein 644 -0.0169314
MDFIC MyoD family inhibitor domain containing -0.0169288
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0169037
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0169021
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0168951
XPO7 exportin 7 -0.016837
HSPB1 heat shock 27kDa protein 1 -0.0167871
PRKD2 protein kinase D2 -0.0167631
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0167631
LIPH lipase, member H -0.0167326
CEP89 centrosomal protein 89kDa -0.0167216
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -0.0167085
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0167067
FAM135A family with sequence similarity 135, member A -0.0165973
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0165722
IPO11 importin 11 -0.0165016
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) -0.0164774
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0164373
MYO15B myosin XVB -0.0163878
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -0.0163697
EXD3 exonuclease 3'-5' domain containing 3 -0.0163622
RNF217 ring finger protein 217 -0.0163441
WDR59 WD repeat domain 59 -0.0163262
STK38 serine/threonine kinase 38 -0.0162846
ADGRV1 adhesion G protein-coupled receptor V1 -0.0162811
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.016281
LUC7L LUC7-like (S. cerevisiae) -0.016236
FOXK2 forkhead box K2 -0.0162165
ITCH itchy E3 ubiquitin protein ligase -0.0161975
TNS4 tensin 4 -0.0161968
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.0161707
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0161597
NSUN6 NOP2/Sun domain family, member 6 -0.0160759
RBL2 retinoblastoma-like 2 -0.0160396
MSH3 mutS homolog 3 -0.0160392
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0160374
BAX BCL2-associated X protein -0.0160318
RPS14 ribosomal protein S14 -0.016018
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B -0.0160152
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 -0.0160125
INTS6 integrator complex subunit 6 -0.0159759
RILPL1 Rab interacting lysosomal protein-like 1 -0.0159559
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.015932
PNPLA8 patatin-like phospholipase domain containing 8 -0.0159102
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0159041
FRK fyn-related Src family tyrosine kinase -0.01588
NFX1 nuclear transcription factor, X-box binding 1 -0.0158684
EIF5 eukaryotic translation initiation factor 5 -0.015835
WASHC5 WASH complex subunit 5 -0.0158223
CLNS1A chloride channel, nucleotide-sensitive, 1A -0.0158205
CD99L2 CD99 molecule-like 2 -0.0157249
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0157236
PCNX1 pecanex 1 -0.0157183
PER2 period circadian clock 2 -0.0156751
PEX14 peroxisomal biogenesis factor 14 -0.0156692
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha -0.015637
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.0156244
SPPL2A signal peptide peptidase like 2A -0.0156157
TPST1 tyrosylprotein sulfotransferase 1 -0.0156128
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 -0.0155021
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) -0.0154529
NLK nemo-like kinase -0.015439
FOXN3 forkhead box N3 -0.0154374
IREB2 iron-responsive element binding protein 2 -0.0154131
EAPP E2F-associated phosphoprotein -0.0153849
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 -0.0153724
STAU2 staufen double-stranded RNA binding protein 2 -0.0153721
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit -0.0153707
TLK1 tousled-like kinase 1 -0.0153675
TM4SF4 transmembrane 4 L six family member 4 -0.0153534
DHX30 DEAH (Asp-Glu-Ala-His) box helicase 30 -0.0153463
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9 -0.0153076
PPP1R12B protein phosphatase 1, regulatory subunit 12B -0.0152993
SNX1 sorting nexin 1 -0.0152966
THADA thyroid adenoma associated -0.0152895
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0152769
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 -0.0152728
LPCAT3 lysophosphatidylcholine acyltransferase 3 -0.0152579
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 -0.0152407
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0152304
NSD3 nuclear receptor binding SET domain protein 3 -0.0152138
KLHL29 kelch-like family member 29 -0.0152114
TALDO1 transaldolase 1 -0.0151788
PTPRG protein tyrosine phosphatase, receptor type, G -0.01516
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) -0.0150779
LRRC41 leucine rich repeat containing 41 -0.0150737
DAPK1 death-associated protein kinase 1 -0.0150582
LPAR1 lysophosphatidic acid receptor 1 -0.0150442
NUP35 nucleoporin 35kDa -0.0150318
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 -0.0150053
AAGAB alpha- and gamma-adaptin binding protein -0.014982
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 -0.0149589
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0149459
PM20D1 peptidase M20 domain containing 1 -0.0149454
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0149262
TANK TRAF family member-associated NFKB activator -0.0149141
DIS3L2 DIS3 like 3'-5' exoribonuclease 2 -0.0149107
CLTCL1 clathrin, heavy chain-like 1 -0.0148963
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -0.0148904
GLS2 glutaminase 2 (liver, mitochondrial) -0.0148476
PPA2 pyrophosphatase (inorganic) 2 -0.0148217
AHI1 Abelson helper integration site 1 -0.0148099
ATP9B ATPase, class II, type 9B -0.0148036
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 -0.0147936
UBXN7 UBX domain protein 7 -0.0147923
ELOVL1 ELOVL fatty acid elongase 1 -0.0147609
GLG1 golgi glycoprotein 1 -0.0147407
SCFD1 sec1 family domain containing 1 -0.0147207
KLC1 kinesin light chain 1 -0.0147092
TSEN2 TSEN2 tRNA splicing endonuclease subunit -0.0147017
CEP95 centrosomal protein 95kDa -0.014687
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0146346
NBDY negative regulator of P-body association -0.0146237
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 -0.0146104
PDK4 pyruvate dehydrogenase kinase, isozyme 4 -0.0145965
ATXN1 ataxin 1 -0.0145842
DMAC2 distal membrane arm assembly component 2 -0.0145797
NT5C2 5'-nucleotidase, cytosolic II -0.0145716
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) -0.0145553
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0145421
DDI2 DNA-damage inducible 1 homolog 2 (S. cerevisiae) -0.0145251
NIPSNAP2 nipsnap homolog 2 -0.0144903
SLMAP sarcolemma associated protein -0.0144572
RAP1GAP2 RAP1 GTPase activating protein 2 -0.0144481
FASN fatty acid synthase -0.0144416
CEMIP2 cell migration inducing hyaluronidase 2 -0.0144159
CDK13 cyclin-dependent kinase 13 -0.0144078
PITPNA phosphatidylinositol transfer protein, alpha -0.0143971
ZNF331 zinc finger protein 331 -0.0143859
ZNF565 zinc finger protein 565 -0.0143814
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta -0.0143631
AP2A2 adaptor-related protein complex 2, alpha 2 subunit -0.0143149
KRIT1 KRIT1, ankyrin repeat containing -0.0143124
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.0143089